-- dump date 20140620_000724 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1091045000001 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1091045000002 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1091045000003 active site 1091045000004 HIGH motif; other site 1091045000005 dimer interface [polypeptide binding]; other site 1091045000006 KMSKS motif; other site 1091045000007 arginine repressor; Provisional; Region: PRK03341 1091045000008 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1091045000009 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1091045000010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045000011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045000012 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1091045000013 biotin synthase; Validated; Region: PRK06256 1091045000014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045000015 FeS/SAM binding site; other site 1091045000016 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1091045000017 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1091045000018 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1091045000019 putative tRNA-binding site [nucleotide binding]; other site 1091045000020 B3/4 domain; Region: B3_4; pfam03483 1091045000021 tRNA synthetase B5 domain; Region: B5; pfam03484 1091045000022 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1091045000023 dimer interface [polypeptide binding]; other site 1091045000024 motif 1; other site 1091045000025 motif 3; other site 1091045000026 motif 2; other site 1091045000027 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1091045000028 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1091045000029 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1091045000030 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1091045000031 dimer interface [polypeptide binding]; other site 1091045000032 motif 1; other site 1091045000033 active site 1091045000034 motif 2; other site 1091045000035 motif 3; other site 1091045000036 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1091045000037 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1091045000038 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091045000039 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1091045000040 23S rRNA binding site [nucleotide binding]; other site 1091045000041 L21 binding site [polypeptide binding]; other site 1091045000042 L13 binding site [polypeptide binding]; other site 1091045000043 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1091045000044 translation initiation factor IF-3; Region: infC; TIGR00168 1091045000045 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1091045000046 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1091045000047 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1091045000048 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1091045000049 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1091045000050 HisG, C-terminal domain; Region: HisG_C; pfam08029 1091045000051 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1091045000052 homodimer interface [polypeptide binding]; other site 1091045000053 putative metal binding site [ion binding]; other site 1091045000054 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1091045000055 conserved hypothetical protein; Region: TIGR03843 1091045000056 conserved hypothetical protein; Region: TIGR03847 1091045000057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091045000058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091045000059 active site 1091045000060 catalytic tetrad [active] 1091045000061 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1091045000062 dimer interface [polypeptide binding]; other site 1091045000063 Citrate synthase; Region: Citrate_synt; pfam00285 1091045000064 active site 1091045000065 citrylCoA binding site [chemical binding]; other site 1091045000066 NADH binding [chemical binding]; other site 1091045000067 cationic pore residues; other site 1091045000068 oxalacetate/citrate binding site [chemical binding]; other site 1091045000069 coenzyme A binding site [chemical binding]; other site 1091045000070 catalytic triad [active] 1091045000071 hypothetical protein; Provisional; Region: PRK07906 1091045000072 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1091045000073 putative metal binding site [ion binding]; other site 1091045000074 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1091045000075 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091045000076 CsbD-like; Region: CsbD; pfam05532 1091045000077 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1091045000078 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1091045000079 DNA binding site [nucleotide binding] 1091045000080 active site 1091045000081 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1091045000082 DNA protecting protein DprA; Region: dprA; TIGR00732 1091045000083 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1091045000084 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1091045000085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045000086 Walker A motif; other site 1091045000087 ATP binding site [chemical binding]; other site 1091045000088 Walker B motif; other site 1091045000089 arginine finger; other site 1091045000090 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1091045000091 hypothetical protein; Reviewed; Region: PRK12497 1091045000092 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1091045000093 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1091045000094 RNA/DNA hybrid binding site [nucleotide binding]; other site 1091045000095 active site 1091045000096 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1091045000097 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1091045000098 Catalytic site [active] 1091045000099 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1091045000100 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1091045000101 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1091045000102 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1091045000103 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1091045000104 L-aspartate oxidase; Provisional; Region: PRK06175 1091045000105 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1091045000106 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1091045000107 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1091045000108 proximal heme binding site [chemical binding]; other site 1091045000109 distal heme binding site [chemical binding]; other site 1091045000110 putative dimer interface [polypeptide binding]; other site 1091045000111 putative Iron-sulfur protein interface [polypeptide binding]; other site 1091045000112 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1091045000113 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1091045000114 RimM N-terminal domain; Region: RimM; pfam01782 1091045000115 PRC-barrel domain; Region: PRC; pfam05239 1091045000116 hypothetical protein; Provisional; Region: PRK02821 1091045000117 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1091045000118 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1091045000119 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091045000120 Amidohydrolase; Region: Amidohydro_4; pfam13147 1091045000121 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091045000122 active site 1091045000123 signal recognition particle protein; Provisional; Region: PRK10867 1091045000124 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1091045000125 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1091045000126 P loop; other site 1091045000127 GTP binding site [chemical binding]; other site 1091045000128 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1091045000129 Predicted esterase [General function prediction only]; Region: COG0627 1091045000130 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1091045000131 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1091045000132 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1091045000133 P loop; other site 1091045000134 GTP binding site [chemical binding]; other site 1091045000135 Predicted membrane protein [Function unknown]; Region: COG2246 1091045000136 GtrA-like protein; Region: GtrA; pfam04138 1091045000137 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1091045000138 HicB family; Region: HicB; pfam05534 1091045000139 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1091045000140 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1091045000141 DNA binding site [nucleotide binding] 1091045000142 catalytic residue [active] 1091045000143 H2TH interface [polypeptide binding]; other site 1091045000144 putative catalytic residues [active] 1091045000145 turnover-facilitating residue; other site 1091045000146 intercalation triad [nucleotide binding]; other site 1091045000147 8OG recognition residue [nucleotide binding]; other site 1091045000148 putative reading head residues; other site 1091045000149 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091045000150 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091045000151 ribonuclease III; Reviewed; Region: rnc; PRK00102 1091045000152 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1091045000153 dimerization interface [polypeptide binding]; other site 1091045000154 active site 1091045000155 metal binding site [ion binding]; metal-binding site 1091045000156 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1091045000157 dsRNA binding site [nucleotide binding]; other site 1091045000158 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1091045000159 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1091045000160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1091045000161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045000162 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1091045000163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000164 dimer interface [polypeptide binding]; other site 1091045000165 conserved gate region; other site 1091045000166 putative PBP binding loops; other site 1091045000167 ABC-ATPase subunit interface; other site 1091045000168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045000169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000170 dimer interface [polypeptide binding]; other site 1091045000171 conserved gate region; other site 1091045000172 putative PBP binding loops; other site 1091045000173 ABC-ATPase subunit interface; other site 1091045000174 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045000175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045000176 DNA binding site [nucleotide binding] 1091045000177 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1091045000178 ligand binding site [chemical binding]; other site 1091045000179 dimerization interface [polypeptide binding]; other site 1091045000180 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1091045000181 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1091045000182 active site 1091045000183 catalytic site [active] 1091045000184 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1091045000185 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1091045000186 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1091045000187 active site 1091045000188 (T/H)XGH motif; other site 1091045000189 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1091045000190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045000191 S-adenosylmethionine binding site [chemical binding]; other site 1091045000192 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1091045000193 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1091045000194 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1091045000195 ssDNA binding site; other site 1091045000196 generic binding surface II; other site 1091045000197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045000198 ATP binding site [chemical binding]; other site 1091045000199 putative Mg++ binding site [ion binding]; other site 1091045000200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045000201 nucleotide binding region [chemical binding]; other site 1091045000202 ATP-binding site [chemical binding]; other site 1091045000203 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1091045000204 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1091045000205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091045000206 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1091045000207 pyruvate dehydrogenase; Provisional; Region: PRK06546 1091045000208 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1091045000209 PYR/PP interface [polypeptide binding]; other site 1091045000210 dimer interface [polypeptide binding]; other site 1091045000211 tetramer interface [polypeptide binding]; other site 1091045000212 TPP binding site [chemical binding]; other site 1091045000213 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1091045000214 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1091045000215 TPP-binding site [chemical binding]; other site 1091045000216 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1091045000217 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1091045000218 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1091045000219 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1091045000220 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1091045000221 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1091045000222 oligomer interface [polypeptide binding]; other site 1091045000223 RNA binding site [nucleotide binding]; other site 1091045000224 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1091045000225 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1091045000226 RNase E interface [polypeptide binding]; other site 1091045000227 trimer interface [polypeptide binding]; other site 1091045000228 active site 1091045000229 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1091045000230 putative nucleic acid binding region [nucleotide binding]; other site 1091045000231 G-X-X-G motif; other site 1091045000232 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1091045000233 RNA binding site [nucleotide binding]; other site 1091045000234 domain interface; other site 1091045000235 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1091045000236 16S/18S rRNA binding site [nucleotide binding]; other site 1091045000237 S13e-L30e interaction site [polypeptide binding]; other site 1091045000238 25S rRNA binding site [nucleotide binding]; other site 1091045000239 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1091045000240 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1091045000241 active site 1091045000242 Riboflavin kinase; Region: Flavokinase; smart00904 1091045000243 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1091045000244 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1091045000245 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1091045000246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000247 dimer interface [polypeptide binding]; other site 1091045000248 conserved gate region; other site 1091045000249 ABC-ATPase subunit interface; other site 1091045000250 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1091045000251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045000252 Walker A/P-loop; other site 1091045000253 ATP binding site [chemical binding]; other site 1091045000254 Q-loop/lid; other site 1091045000255 ABC transporter signature motif; other site 1091045000256 Walker B; other site 1091045000257 D-loop; other site 1091045000258 H-loop/switch region; other site 1091045000259 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1091045000260 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1091045000261 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1091045000262 RNA binding site [nucleotide binding]; other site 1091045000263 active site 1091045000264 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1091045000265 Cupin domain; Region: Cupin_2; cl17218 1091045000266 potential frameshift: common BLAST hit: gi|295131030|ref|YP_003581693.1| PRD domain protein 1091045000267 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1091045000268 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1091045000269 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1091045000270 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1091045000271 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1091045000272 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1091045000273 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1091045000274 dimerization domain swap beta strand [polypeptide binding]; other site 1091045000275 regulatory protein interface [polypeptide binding]; other site 1091045000276 active site 1091045000277 regulatory phosphorylation site [posttranslational modification]; other site 1091045000278 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1091045000279 active site 1091045000280 metal binding site [ion binding]; metal-binding site 1091045000281 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1091045000282 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1091045000283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045000284 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1091045000285 Walker A/P-loop; other site 1091045000286 ATP binding site [chemical binding]; other site 1091045000287 Q-loop/lid; other site 1091045000288 ABC transporter signature motif; other site 1091045000289 Walker B; other site 1091045000290 D-loop; other site 1091045000291 H-loop/switch region; other site 1091045000292 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1091045000293 translation initiation factor IF-2; Region: IF-2; TIGR00487 1091045000294 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1091045000295 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1091045000296 G1 box; other site 1091045000297 putative GEF interaction site [polypeptide binding]; other site 1091045000298 GTP/Mg2+ binding site [chemical binding]; other site 1091045000299 Switch I region; other site 1091045000300 G2 box; other site 1091045000301 G3 box; other site 1091045000302 Switch II region; other site 1091045000303 G4 box; other site 1091045000304 G5 box; other site 1091045000305 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1091045000306 Translation-initiation factor 2; Region: IF-2; pfam11987 1091045000307 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1091045000308 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1091045000309 putative RNA binding cleft [nucleotide binding]; other site 1091045000310 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1091045000311 NusA N-terminal domain; Region: NusA_N; pfam08529 1091045000312 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1091045000313 RNA binding site [nucleotide binding]; other site 1091045000314 homodimer interface [polypeptide binding]; other site 1091045000315 NusA-like KH domain; Region: KH_5; pfam13184 1091045000316 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1091045000317 G-X-X-G motif; other site 1091045000318 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1091045000319 Sm and related proteins; Region: Sm_like; cl00259 1091045000320 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1091045000321 putative oligomer interface [polypeptide binding]; other site 1091045000322 putative RNA binding site [nucleotide binding]; other site 1091045000323 hypothetical protein; Provisional; Region: PRK10621 1091045000324 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1091045000325 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 1091045000326 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1091045000327 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1091045000328 dimer interface [polypeptide binding]; other site 1091045000329 motif 1; other site 1091045000330 active site 1091045000331 motif 2; other site 1091045000332 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1091045000333 putative deacylase active site [active] 1091045000334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091045000335 active site 1091045000336 motif 3; other site 1091045000337 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1091045000338 anticodon binding site; other site 1091045000339 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1091045000340 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1091045000341 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1091045000342 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1091045000343 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1091045000344 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045000345 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1091045000346 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1091045000347 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045000348 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1091045000349 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1091045000350 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1091045000351 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1091045000352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045000353 ABC-ATPase subunit interface; other site 1091045000354 dimer interface [polypeptide binding]; other site 1091045000355 putative PBP binding regions; other site 1091045000356 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1091045000357 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1091045000358 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1091045000359 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1091045000360 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1091045000361 potential frameshift: common BLAST hit: gi|68536120|ref|YP_250825.1| putative extracellular nuclease 1091045000362 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1091045000363 generic binding surface I; other site 1091045000364 generic binding surface II; other site 1091045000365 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1091045000366 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1091045000367 active site 1091045000368 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1091045000369 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1091045000370 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1091045000371 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1091045000372 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1091045000373 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091045000374 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091045000375 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1091045000376 glutamate dehydrogenase; Provisional; Region: PRK09414 1091045000377 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1091045000378 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1091045000379 NAD(P) binding site [chemical binding]; other site 1091045000380 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1091045000381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045000382 FeS/SAM binding site; other site 1091045000383 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1091045000384 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1091045000385 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1091045000386 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1091045000387 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1091045000388 hinge region; other site 1091045000389 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1091045000390 putative nucleotide binding site [chemical binding]; other site 1091045000391 uridine monophosphate binding site [chemical binding]; other site 1091045000392 homohexameric interface [polypeptide binding]; other site 1091045000393 elongation factor Ts; Provisional; Region: tsf; PRK09377 1091045000394 UBA/TS-N domain; Region: UBA; pfam00627 1091045000395 Elongation factor TS; Region: EF_TS; pfam00889 1091045000396 Elongation factor TS; Region: EF_TS; pfam00889 1091045000397 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1091045000398 rRNA interaction site [nucleotide binding]; other site 1091045000399 S8 interaction site; other site 1091045000400 putative laminin-1 binding site; other site 1091045000401 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1091045000402 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091045000403 active site 1091045000404 DNA binding site [nucleotide binding] 1091045000405 Int/Topo IB signature motif; other site 1091045000406 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1091045000407 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1091045000408 active site 1091045000409 catalytic residues [active] 1091045000410 metal binding site [ion binding]; metal-binding site 1091045000411 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1091045000412 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1091045000413 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091045000414 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1091045000415 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1091045000416 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1091045000417 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1091045000418 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1091045000419 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1091045000420 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1091045000421 Walker A/P-loop; other site 1091045000422 ATP binding site [chemical binding]; other site 1091045000423 Q-loop/lid; other site 1091045000424 ABC transporter signature motif; other site 1091045000425 Walker B; other site 1091045000426 D-loop; other site 1091045000427 H-loop/switch region; other site 1091045000428 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1091045000429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091045000430 NAD(P) binding site [chemical binding]; other site 1091045000431 active site 1091045000432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091045000433 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1091045000434 NAD(P) binding site [chemical binding]; other site 1091045000435 active site 1091045000436 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1091045000437 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1091045000438 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1091045000439 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1091045000440 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1091045000441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045000442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045000443 Walker A/P-loop; other site 1091045000444 ATP binding site [chemical binding]; other site 1091045000445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045000446 ABC transporter signature motif; other site 1091045000447 Walker B; other site 1091045000448 D-loop; other site 1091045000449 ABC transporter; Region: ABC_tran_2; pfam12848 1091045000450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045000451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091045000452 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1091045000453 Coenzyme A binding pocket [chemical binding]; other site 1091045000454 potential frameshift: common BLAST hit: gi|365974416|ref|YP_004955975.1| pyridine nucleotide-disulfide oxidoreductase 1091045000455 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045000456 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045000457 phosphate binding site [ion binding]; other site 1091045000458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091045000459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045000460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045000461 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1091045000462 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1091045000463 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1091045000464 trimerization site [polypeptide binding]; other site 1091045000465 active site 1091045000466 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1091045000467 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1091045000468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045000469 catalytic residue [active] 1091045000470 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1091045000471 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1091045000472 Walker A/P-loop; other site 1091045000473 ATP binding site [chemical binding]; other site 1091045000474 Q-loop/lid; other site 1091045000475 ABC transporter signature motif; other site 1091045000476 Walker B; other site 1091045000477 D-loop; other site 1091045000478 H-loop/switch region; other site 1091045000479 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1091045000480 [2Fe-2S] cluster binding site [ion binding]; other site 1091045000481 FeS assembly protein SufD; Region: sufD; TIGR01981 1091045000482 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1091045000483 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1091045000484 FeS assembly protein SufB; Region: sufB; TIGR01980 1091045000485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091045000486 dimerization interface [polypeptide binding]; other site 1091045000487 putative DNA binding site [nucleotide binding]; other site 1091045000488 Predicted transcriptional regulator [Transcription]; Region: COG2345 1091045000489 putative Zn2+ binding site [ion binding]; other site 1091045000490 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1091045000491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045000492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000493 dimer interface [polypeptide binding]; other site 1091045000494 conserved gate region; other site 1091045000495 putative PBP binding loops; other site 1091045000496 ABC-ATPase subunit interface; other site 1091045000497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045000498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000499 dimer interface [polypeptide binding]; other site 1091045000500 conserved gate region; other site 1091045000501 putative PBP binding loops; other site 1091045000502 ABC-ATPase subunit interface; other site 1091045000503 potential frameshift: common BLAST hit: gi|50843030|ref|YP_056257.1| MalR repressor protein 1091045000504 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1091045000505 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1091045000506 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1091045000507 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091045000508 Walker A/P-loop; other site 1091045000509 ATP binding site [chemical binding]; other site 1091045000510 Q-loop/lid; other site 1091045000511 ABC transporter signature motif; other site 1091045000512 Walker B; other site 1091045000513 D-loop; other site 1091045000514 H-loop/switch region; other site 1091045000515 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1091045000516 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091045000517 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1091045000518 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1091045000519 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1091045000520 catalytic site [active] 1091045000521 BNR repeat-like domain; Region: BNR_2; pfam13088 1091045000522 Asp-box motif; other site 1091045000523 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1091045000524 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091045000525 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1091045000526 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1091045000527 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1091045000528 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1091045000529 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1091045000530 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1091045000531 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1091045000532 putative active site [active] 1091045000533 DoxX; Region: DoxX; pfam07681 1091045000534 Thioredoxin; Region: Thioredoxin_4; cl17273 1091045000535 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1091045000536 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1091045000537 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045000538 active site 1091045000539 HIGH motif; other site 1091045000540 nucleotide binding site [chemical binding]; other site 1091045000541 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045000542 active site 1091045000543 KMSKS motif; other site 1091045000544 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1091045000545 tRNA binding surface [nucleotide binding]; other site 1091045000546 anticodon binding site; other site 1091045000547 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1091045000548 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 1091045000549 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1091045000550 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1091045000551 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1091045000552 Orbivirus outer capsid protein VP2; Region: Orbi_VP2; pfam00898 1091045000553 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1091045000554 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1091045000555 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1091045000556 protein binding site [polypeptide binding]; other site 1091045000557 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1091045000558 Domain interface; other site 1091045000559 Peptide binding site; other site 1091045000560 Active site tetrad [active] 1091045000561 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1091045000562 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1091045000563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045000564 Walker A motif; other site 1091045000565 ATP binding site [chemical binding]; other site 1091045000566 Walker B motif; other site 1091045000567 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1091045000568 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1091045000569 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1091045000570 oligomer interface [polypeptide binding]; other site 1091045000571 active site residues [active] 1091045000572 Clp protease; Region: CLP_protease; pfam00574 1091045000573 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1091045000574 oligomer interface [polypeptide binding]; other site 1091045000575 active site residues [active] 1091045000576 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091045000577 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091045000578 trigger factor; Provisional; Region: tig; PRK01490 1091045000579 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091045000580 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1091045000581 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1091045000582 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1091045000583 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091045000584 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1091045000585 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1091045000586 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1091045000587 dimer interface [polypeptide binding]; other site 1091045000588 putative anticodon binding site; other site 1091045000589 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091045000590 motif 1; other site 1091045000591 dimer interface [polypeptide binding]; other site 1091045000592 active site 1091045000593 motif 2; other site 1091045000594 motif 3; other site 1091045000595 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1091045000596 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1091045000597 putative DNA binding site [nucleotide binding]; other site 1091045000598 catalytic residue [active] 1091045000599 putative H2TH interface [polypeptide binding]; other site 1091045000600 putative catalytic residues [active] 1091045000601 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091045000602 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091045000603 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1091045000604 hypothetical protein; Provisional; Region: PRK01346 1091045000605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091045000606 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1091045000607 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1091045000608 nucleotide binding pocket [chemical binding]; other site 1091045000609 K-X-D-G motif; other site 1091045000610 catalytic site [active] 1091045000611 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1091045000612 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1091045000613 Helix-hairpin-helix motif; Region: HHH; pfam00633 1091045000614 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1091045000615 Dimer interface [polypeptide binding]; other site 1091045000616 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1091045000617 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1091045000618 Zn binding site [ion binding]; other site 1091045000619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091045000620 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1091045000621 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1091045000622 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1091045000623 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1091045000624 active site 1091045000625 catalytic site [active] 1091045000626 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091045000627 active site 1091045000628 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091045000629 active site 1091045000630 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1091045000631 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1091045000632 acyl-activating enzyme (AAE) consensus motif; other site 1091045000633 putative AMP binding site [chemical binding]; other site 1091045000634 putative active site [active] 1091045000635 putative CoA binding site [chemical binding]; other site 1091045000636 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091045000637 MarR family; Region: MarR_2; pfam12802 1091045000638 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091045000639 FAD binding domain; Region: FAD_binding_4; pfam01565 1091045000640 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1091045000641 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1091045000642 Predicted transcriptional regulators [Transcription]; Region: COG1695 1091045000643 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1091045000644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045000645 Walker A/P-loop; other site 1091045000646 ATP binding site [chemical binding]; other site 1091045000647 Q-loop/lid; other site 1091045000648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045000649 ABC transporter; Region: ABC_tran_2; pfam12848 1091045000650 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045000651 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1091045000652 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1091045000653 dimer interface [polypeptide binding]; other site 1091045000654 ssDNA binding site [nucleotide binding]; other site 1091045000655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091045000656 YfjP GTPase; Region: YfjP; cd11383 1091045000657 G1 box; other site 1091045000658 GTP/Mg2+ binding site [chemical binding]; other site 1091045000659 Switch I region; other site 1091045000660 G2 box; other site 1091045000661 Switch II region; other site 1091045000662 G3 box; other site 1091045000663 G4 box; other site 1091045000664 G5 box; other site 1091045000665 Dynamin family; Region: Dynamin_N; pfam00350 1091045000666 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091045000667 G1 box; other site 1091045000668 GTP/Mg2+ binding site [chemical binding]; other site 1091045000669 G2 box; other site 1091045000670 Switch I region; other site 1091045000671 Protease prsW family; Region: PrsW-protease; pfam13367 1091045000672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045000673 putative substrate translocation pore; other site 1091045000674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045000675 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1091045000676 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1091045000677 catalytic site [active] 1091045000678 putative active site [active] 1091045000679 putative substrate binding site [chemical binding]; other site 1091045000680 dimer interface [polypeptide binding]; other site 1091045000681 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1091045000682 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091045000683 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091045000684 active site 1091045000685 ATP binding site [chemical binding]; other site 1091045000686 substrate binding site [chemical binding]; other site 1091045000687 activation loop (A-loop); other site 1091045000688 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1091045000689 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1091045000690 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1091045000691 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1091045000692 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1091045000693 active site 1091045000694 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1091045000695 generic binding surface I; other site 1091045000696 generic binding surface II; other site 1091045000697 DNA Polymerase Y-family; Region: PolY_like; cd03468 1091045000698 active site 1091045000699 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1091045000700 DNA binding site [nucleotide binding] 1091045000701 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1091045000702 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1091045000703 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1091045000704 catalytic triad [active] 1091045000705 potential frameshift: common BLAST hit: gi|295131174|ref|YP_003581837.1| bacterial extracellular solute-binding protein 1091045000706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000707 dimer interface [polypeptide binding]; other site 1091045000708 conserved gate region; other site 1091045000709 putative PBP binding loops; other site 1091045000710 ABC-ATPase subunit interface; other site 1091045000711 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045000712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045000713 dimer interface [polypeptide binding]; other site 1091045000714 conserved gate region; other site 1091045000715 putative PBP binding loops; other site 1091045000716 ABC-ATPase subunit interface; other site 1091045000717 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1091045000718 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1091045000719 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1091045000720 catalytic triad [active] 1091045000721 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1091045000722 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1091045000723 active site 1091045000724 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1091045000725 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1091045000726 active site 1091045000727 catalytic triad [active] 1091045000728 oxyanion hole [active] 1091045000729 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1091045000730 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1091045000731 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1091045000732 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1091045000733 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1091045000734 putative active site [active] 1091045000735 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1091045000736 DNA polymerase IV; Provisional; Region: PRK03348 1091045000737 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1091045000738 active site 1091045000739 DNA binding site [nucleotide binding] 1091045000740 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1091045000741 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1091045000742 folate binding site [chemical binding]; other site 1091045000743 NADP+ binding site [chemical binding]; other site 1091045000744 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1091045000745 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1091045000746 dimerization interface [polypeptide binding]; other site 1091045000747 active site 1091045000748 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1091045000749 active site 1091045000750 dimerization interface [polypeptide binding]; other site 1091045000751 ribonuclease PH; Reviewed; Region: rph; PRK00173 1091045000752 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1091045000753 hexamer interface [polypeptide binding]; other site 1091045000754 active site 1091045000755 glutamate racemase; Provisional; Region: PRK00865 1091045000756 FeoA domain; Region: FeoA; pfam04023 1091045000757 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1091045000758 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1091045000759 G1 box; other site 1091045000760 GTP/Mg2+ binding site [chemical binding]; other site 1091045000761 Switch I region; other site 1091045000762 G2 box; other site 1091045000763 G3 box; other site 1091045000764 Switch II region; other site 1091045000765 G4 box; other site 1091045000766 G5 box; other site 1091045000767 Nucleoside recognition; Region: Gate; pfam07670 1091045000768 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1091045000769 Nucleoside recognition; Region: Gate; pfam07670 1091045000770 NifU-like domain; Region: NifU; cl00484 1091045000771 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1091045000772 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1091045000773 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1091045000774 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1091045000775 active site 1091045000776 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1091045000777 IHF dimer interface [polypeptide binding]; other site 1091045000778 IHF - DNA interface [nucleotide binding]; other site 1091045000779 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1091045000780 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1091045000781 RDD family; Region: RDD; pfam06271 1091045000782 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1091045000783 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1091045000784 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1091045000785 trimer interface [polypeptide binding]; other site 1091045000786 active site 1091045000787 dimer interface [polypeptide binding]; other site 1091045000788 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1091045000789 Cation efflux family; Region: Cation_efflux; pfam01545 1091045000790 Trm112p-like protein; Region: Trm112p; cl01066 1091045000791 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1091045000792 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1091045000793 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 1091045000794 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1091045000795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091045000796 active site 1091045000797 Transcription factor WhiB; Region: Whib; pfam02467 1091045000798 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1091045000799 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1091045000800 Substrate binding site; other site 1091045000801 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1091045000802 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1091045000803 Ligand binding site; other site 1091045000804 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1091045000805 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1091045000806 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1091045000807 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1091045000808 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1091045000809 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1091045000810 AIR carboxylase; Region: AIRC; pfam00731 1091045000811 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1091045000812 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1091045000813 NAD binding site [chemical binding]; other site 1091045000814 ATP-grasp domain; Region: ATP-grasp; pfam02222 1091045000815 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1091045000816 active site pocket [active] 1091045000817 oxyanion hole [active] 1091045000818 catalytic triad [active] 1091045000819 active site nucleophile [active] 1091045000820 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1091045000821 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1091045000822 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1091045000823 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1091045000824 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1091045000825 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1091045000826 Maf-like protein; Region: Maf; pfam02545 1091045000827 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1091045000828 active site 1091045000829 dimer interface [polypeptide binding]; other site 1091045000830 short chain dehydrogenase; Provisional; Region: PRK08219 1091045000831 classical (c) SDRs; Region: SDR_c; cd05233 1091045000832 NAD(P) binding site [chemical binding]; other site 1091045000833 active site 1091045000834 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1091045000835 dimer interface [polypeptide binding]; other site 1091045000836 substrate binding site [chemical binding]; other site 1091045000837 ATP binding site [chemical binding]; other site 1091045000838 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1091045000839 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1091045000840 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1091045000841 TQXA domain; Region: TQXA_dom; TIGR03934 1091045000842 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1091045000843 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1091045000844 oligomer interface [polypeptide binding]; other site 1091045000845 metal binding site [ion binding]; metal-binding site 1091045000846 metal binding site [ion binding]; metal-binding site 1091045000847 putative Cl binding site [ion binding]; other site 1091045000848 aspartate ring; other site 1091045000849 basic sphincter; other site 1091045000850 hydrophobic gate; other site 1091045000851 periplasmic entrance; other site 1091045000852 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1091045000853 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1091045000854 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091045000855 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1091045000856 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1091045000857 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091045000858 carboxyltransferase (CT) interaction site; other site 1091045000859 biotinylation site [posttranslational modification]; other site 1091045000860 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1091045000861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045000862 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091045000863 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1091045000864 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1091045000865 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1091045000866 active site 1091045000867 substrate binding site [chemical binding]; other site 1091045000868 metal binding site [ion binding]; metal-binding site 1091045000869 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1091045000870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091045000871 acyl-activating enzyme (AAE) consensus motif; other site 1091045000872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091045000873 AMP binding site [chemical binding]; other site 1091045000874 active site 1091045000875 acyl-activating enzyme (AAE) consensus motif; other site 1091045000876 CoA binding site [chemical binding]; other site 1091045000877 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1091045000878 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1091045000879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045000880 putative substrate translocation pore; other site 1091045000881 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1091045000882 active site 1091045000883 catalytic site [active] 1091045000884 substrate binding site [chemical binding]; other site 1091045000885 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1091045000886 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1091045000887 active site 1091045000888 HIGH motif; other site 1091045000889 KMSKS motif; other site 1091045000890 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1091045000891 tRNA binding surface [nucleotide binding]; other site 1091045000892 anticodon binding site; other site 1091045000893 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1091045000894 RNA/DNA hybrid binding site [nucleotide binding]; other site 1091045000895 active site 1091045000896 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1091045000897 active site 1091045000898 catalytic motif [active] 1091045000899 Zn binding site [ion binding]; other site 1091045000900 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1091045000901 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1091045000902 TM-ABC transporter signature motif; other site 1091045000903 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1091045000904 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1091045000905 TM-ABC transporter signature motif; other site 1091045000906 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1091045000907 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1091045000908 Walker A/P-loop; other site 1091045000909 ATP binding site [chemical binding]; other site 1091045000910 Q-loop/lid; other site 1091045000911 ABC transporter signature motif; other site 1091045000912 Walker B; other site 1091045000913 D-loop; other site 1091045000914 H-loop/switch region; other site 1091045000915 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1091045000916 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1091045000917 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1091045000918 ligand binding site [chemical binding]; other site 1091045000919 Phosphotransferase enzyme family; Region: APH; pfam01636 1091045000920 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1091045000921 Domain of unknown function DUF21; Region: DUF21; pfam01595 1091045000922 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091045000923 Transporter associated domain; Region: CorC_HlyC; smart01091 1091045000924 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1091045000925 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1091045000926 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1091045000927 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1091045000928 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1091045000929 active site 1091045000930 substrate binding site [chemical binding]; other site 1091045000931 cosubstrate binding site; other site 1091045000932 catalytic site [active] 1091045000933 malate dehydrogenase; Provisional; Region: PRK05442 1091045000934 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1091045000935 NAD(P) binding site [chemical binding]; other site 1091045000936 dimer interface [polypeptide binding]; other site 1091045000937 malate binding site [chemical binding]; other site 1091045000938 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1091045000939 putative catalytic cysteine [active] 1091045000940 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1091045000941 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1091045000942 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1091045000943 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1091045000944 homodimer interface [polypeptide binding]; other site 1091045000945 NADP binding site [chemical binding]; other site 1091045000946 substrate binding site [chemical binding]; other site 1091045000947 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1091045000948 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1091045000949 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1091045000950 purine monophosphate binding site [chemical binding]; other site 1091045000951 dimer interface [polypeptide binding]; other site 1091045000952 putative catalytic residues [active] 1091045000953 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1091045000954 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1091045000955 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1091045000956 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1091045000957 active site 1091045000958 cosubstrate binding site; other site 1091045000959 substrate binding site [chemical binding]; other site 1091045000960 catalytic site [active] 1091045000961 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1091045000962 homopentamer interface [polypeptide binding]; other site 1091045000963 active site 1091045000964 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1091045000965 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1091045000966 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1091045000967 dimerization interface [polypeptide binding]; other site 1091045000968 active site 1091045000969 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1091045000970 Lumazine binding domain; Region: Lum_binding; pfam00677 1091045000971 Lumazine binding domain; Region: Lum_binding; pfam00677 1091045000972 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1091045000973 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1091045000974 catalytic motif [active] 1091045000975 Zn binding site [ion binding]; other site 1091045000976 RibD C-terminal domain; Region: RibD_C; pfam01872 1091045000977 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1091045000978 CoA binding domain; Region: CoA_binding; smart00881 1091045000979 CoA-ligase; Region: Ligase_CoA; pfam00549 1091045000980 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1091045000981 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1091045000982 CoA-ligase; Region: Ligase_CoA; pfam00549 1091045000983 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1091045000984 Part of AAA domain; Region: AAA_19; pfam13245 1091045000985 Family description; Region: UvrD_C_2; pfam13538 1091045000986 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1091045000987 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1091045000988 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1091045000989 Walker A/P-loop; other site 1091045000990 ATP binding site [chemical binding]; other site 1091045000991 Q-loop/lid; other site 1091045000992 ABC transporter signature motif; other site 1091045000993 Walker B; other site 1091045000994 D-loop; other site 1091045000995 H-loop/switch region; other site 1091045000996 NIL domain; Region: NIL; pfam09383 1091045000997 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1091045000998 ABC-ATPase subunit interface; other site 1091045000999 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1091045001000 PLD-like domain; Region: PLDc_2; pfam13091 1091045001001 putative active site [active] 1091045001002 catalytic site [active] 1091045001003 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1091045001004 PLD-like domain; Region: PLDc_2; pfam13091 1091045001005 putative active site [active] 1091045001006 catalytic site [active] 1091045001007 PspC domain; Region: PspC; pfam04024 1091045001008 GMP synthase; Reviewed; Region: guaA; PRK00074 1091045001009 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1091045001010 AMP/PPi binding site [chemical binding]; other site 1091045001011 candidate oxyanion hole; other site 1091045001012 catalytic triad [active] 1091045001013 potential glutamine specificity residues [chemical binding]; other site 1091045001014 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1091045001015 ATP Binding subdomain [chemical binding]; other site 1091045001016 Ligand Binding sites [chemical binding]; other site 1091045001017 Dimerization subdomain; other site 1091045001018 serine O-acetyltransferase; Region: cysE; TIGR01172 1091045001019 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1091045001020 trimer interface [polypeptide binding]; other site 1091045001021 active site 1091045001022 substrate binding site [chemical binding]; other site 1091045001023 CoA binding site [chemical binding]; other site 1091045001024 chorismate mutase; Provisional; Region: PRK09239 1091045001025 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1091045001026 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045001027 phosphate binding site [ion binding]; other site 1091045001028 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1091045001029 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045001030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1091045001031 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1091045001032 active site 1091045001033 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1091045001034 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1091045001035 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1091045001036 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1091045001037 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1091045001038 ring oligomerisation interface [polypeptide binding]; other site 1091045001039 ATP/Mg binding site [chemical binding]; other site 1091045001040 stacking interactions; other site 1091045001041 hinge regions; other site 1091045001042 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1091045001043 oligomerisation interface [polypeptide binding]; other site 1091045001044 mobile loop; other site 1091045001045 roof hairpin; other site 1091045001046 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1091045001047 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1091045001048 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045001049 Walker A/P-loop; other site 1091045001050 ATP binding site [chemical binding]; other site 1091045001051 Q-loop/lid; other site 1091045001052 ABC transporter signature motif; other site 1091045001053 Walker B; other site 1091045001054 D-loop; other site 1091045001055 H-loop/switch region; other site 1091045001056 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1091045001057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045001058 ABC-ATPase subunit interface; other site 1091045001059 dimer interface [polypeptide binding]; other site 1091045001060 putative PBP binding regions; other site 1091045001061 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1091045001062 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1091045001063 putative ligand binding residues [chemical binding]; other site 1091045001064 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1091045001065 putative active site [active] 1091045001066 nucleotide binding site [chemical binding]; other site 1091045001067 nudix motif; other site 1091045001068 putative metal binding site [ion binding]; other site 1091045001069 UGMP family protein; Validated; Region: PRK09604 1091045001070 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1091045001071 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1091045001072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091045001073 Coenzyme A binding pocket [chemical binding]; other site 1091045001074 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1091045001075 Glycoprotease family; Region: Peptidase_M22; pfam00814 1091045001076 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1091045001077 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1091045001078 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091045001079 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1091045001080 ATP binding site [chemical binding]; other site 1091045001081 Mg++ binding site [ion binding]; other site 1091045001082 motif III; other site 1091045001083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045001084 nucleotide binding region [chemical binding]; other site 1091045001085 ATP-binding site [chemical binding]; other site 1091045001086 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045001087 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045001088 Walker A/P-loop; other site 1091045001089 ATP binding site [chemical binding]; other site 1091045001090 Q-loop/lid; other site 1091045001091 ABC transporter signature motif; other site 1091045001092 Walker B; other site 1091045001093 D-loop; other site 1091045001094 H-loop/switch region; other site 1091045001095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045001096 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1091045001097 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1091045001098 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1091045001099 putative substrate binding site [chemical binding]; other site 1091045001100 putative ATP binding site [chemical binding]; other site 1091045001101 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1091045001102 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1091045001103 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1091045001104 glutaminase active site [active] 1091045001105 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1091045001106 dimer interface [polypeptide binding]; other site 1091045001107 active site 1091045001108 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1091045001109 dimer interface [polypeptide binding]; other site 1091045001110 active site 1091045001111 Lipase (class 2); Region: Lipase_2; pfam01674 1091045001112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091045001113 pantothenate kinase; Provisional; Region: PRK05439 1091045001114 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1091045001115 ATP-binding site [chemical binding]; other site 1091045001116 CoA-binding site [chemical binding]; other site 1091045001117 Mg2+-binding site [ion binding]; other site 1091045001118 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1091045001119 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1091045001120 active site 1091045001121 substrate binding site [chemical binding]; other site 1091045001122 metal binding site [ion binding]; metal-binding site 1091045001123 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1091045001124 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1091045001125 23S rRNA interface [nucleotide binding]; other site 1091045001126 L3 interface [polypeptide binding]; other site 1091045001127 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1091045001128 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 1091045001129 active site 1091045001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045001131 S-adenosylmethionine binding site [chemical binding]; other site 1091045001132 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1091045001133 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1091045001134 dimerization interface 3.5A [polypeptide binding]; other site 1091045001135 active site 1091045001136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045001137 S-adenosylmethionine binding site [chemical binding]; other site 1091045001138 Cobalt transport protein; Region: CbiQ; cl00463 1091045001139 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045001140 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1091045001141 Walker A/P-loop; other site 1091045001142 ATP binding site [chemical binding]; other site 1091045001143 Q-loop/lid; other site 1091045001144 ABC transporter signature motif; other site 1091045001145 Walker B; other site 1091045001146 D-loop; other site 1091045001147 H-loop/switch region; other site 1091045001148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045001149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045001150 Walker A/P-loop; other site 1091045001151 ATP binding site [chemical binding]; other site 1091045001152 Q-loop/lid; other site 1091045001153 ABC transporter signature motif; other site 1091045001154 Walker B; other site 1091045001155 D-loop; other site 1091045001156 H-loop/switch region; other site 1091045001157 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1091045001158 classical (c) SDRs; Region: SDR_c; cd05233 1091045001159 NAD(P) binding site [chemical binding]; other site 1091045001160 active site 1091045001161 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1091045001162 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091045001163 Walker A/P-loop; other site 1091045001164 ATP binding site [chemical binding]; other site 1091045001165 Q-loop/lid; other site 1091045001166 ABC transporter signature motif; other site 1091045001167 Walker B; other site 1091045001168 D-loop; other site 1091045001169 H-loop/switch region; other site 1091045001170 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1091045001171 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1091045001172 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1091045001173 potential frameshift: common BLAST hit: gi|50843277|ref|YP_056504.1| beta-galactosidase fused to beta-N-acetylhexosaminidase 1091045001174 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1091045001175 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1091045001176 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1091045001177 active site 1091045001178 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1091045001179 sugar binding site [chemical binding]; other site 1091045001180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045001182 putative substrate translocation pore; other site 1091045001183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045001184 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1091045001185 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1091045001186 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1091045001187 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1091045001188 alphaNTD homodimer interface [polypeptide binding]; other site 1091045001189 alphaNTD - beta interaction site [polypeptide binding]; other site 1091045001190 alphaNTD - beta' interaction site [polypeptide binding]; other site 1091045001191 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1091045001192 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1091045001193 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1091045001194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091045001195 RNA binding surface [nucleotide binding]; other site 1091045001196 30S ribosomal protein S11; Validated; Region: PRK05309 1091045001197 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1091045001198 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1091045001199 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1091045001200 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1091045001201 rRNA binding site [nucleotide binding]; other site 1091045001202 predicted 30S ribosome binding site; other site 1091045001203 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1091045001204 active site 1091045001205 adenylate kinase; Reviewed; Region: adk; PRK00279 1091045001206 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1091045001207 AMP-binding site [chemical binding]; other site 1091045001208 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1091045001209 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1091045001210 SecY translocase; Region: SecY; pfam00344 1091045001211 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045001212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001213 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1091045001214 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1091045001215 putative active site [active] 1091045001216 catalytic site [active] 1091045001217 putative metal binding site [ion binding]; other site 1091045001218 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1091045001219 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1091045001220 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1091045001221 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1091045001222 potential frameshift: common BLAST hit: gi|271968341|ref|YP_003342537.1| glutathione import ATP-binding protein GsiA 1091045001223 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1091045001224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045001225 dimer interface [polypeptide binding]; other site 1091045001226 conserved gate region; other site 1091045001227 putative PBP binding loops; other site 1091045001228 ABC-ATPase subunit interface; other site 1091045001229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1091045001230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045001231 dimer interface [polypeptide binding]; other site 1091045001232 conserved gate region; other site 1091045001233 putative PBP binding loops; other site 1091045001234 ABC-ATPase subunit interface; other site 1091045001235 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1091045001236 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1091045001237 23S rRNA binding site [nucleotide binding]; other site 1091045001238 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1091045001239 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1091045001240 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1091045001241 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1091045001242 23S rRNA interface [nucleotide binding]; other site 1091045001243 5S rRNA interface [nucleotide binding]; other site 1091045001244 L27 interface [polypeptide binding]; other site 1091045001245 L5 interface [polypeptide binding]; other site 1091045001246 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1091045001247 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1091045001248 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1091045001249 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1091045001250 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1091045001251 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1091045001252 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1091045001253 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1091045001254 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1091045001255 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1091045001256 RNA binding site [nucleotide binding]; other site 1091045001257 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1091045001258 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1091045001259 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1091045001260 23S rRNA interface [nucleotide binding]; other site 1091045001261 putative translocon interaction site; other site 1091045001262 signal recognition particle (SRP54) interaction site; other site 1091045001263 L23 interface [polypeptide binding]; other site 1091045001264 trigger factor interaction site; other site 1091045001265 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1091045001266 23S rRNA interface [nucleotide binding]; other site 1091045001267 5S rRNA interface [nucleotide binding]; other site 1091045001268 putative antibiotic binding site [chemical binding]; other site 1091045001269 L25 interface [polypeptide binding]; other site 1091045001270 L27 interface [polypeptide binding]; other site 1091045001271 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1091045001272 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1091045001273 G-X-X-G motif; other site 1091045001274 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1091045001275 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1091045001276 putative translocon binding site; other site 1091045001277 protein-rRNA interface [nucleotide binding]; other site 1091045001278 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1091045001279 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1091045001280 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1091045001281 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1091045001282 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1091045001283 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 1091045001284 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1091045001285 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1091045001286 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 1091045001287 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1091045001288 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1091045001289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045001290 catalytic residue [active] 1091045001291 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1091045001292 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1091045001293 HIGH motif; other site 1091045001294 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1091045001295 active site 1091045001296 KMSKS motif; other site 1091045001297 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1091045001298 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045001299 active site 1091045001300 HIGH motif; other site 1091045001301 nucleotide binding site [chemical binding]; other site 1091045001302 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045001303 active site 1091045001304 KMSKS motif; other site 1091045001305 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1091045001306 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1091045001307 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1091045001308 active site 1091045001309 metal binding site [ion binding]; metal-binding site 1091045001310 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1091045001311 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1091045001312 elongation factor Tu; Reviewed; Region: PRK00049 1091045001313 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1091045001314 G1 box; other site 1091045001315 GEF interaction site [polypeptide binding]; other site 1091045001316 GTP/Mg2+ binding site [chemical binding]; other site 1091045001317 Switch I region; other site 1091045001318 G2 box; other site 1091045001319 G3 box; other site 1091045001320 Switch II region; other site 1091045001321 G4 box; other site 1091045001322 G5 box; other site 1091045001323 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1091045001324 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1091045001325 Antibiotic Binding Site [chemical binding]; other site 1091045001326 elongation factor G; Reviewed; Region: PRK00007 1091045001327 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1091045001328 G1 box; other site 1091045001329 putative GEF interaction site [polypeptide binding]; other site 1091045001330 GTP/Mg2+ binding site [chemical binding]; other site 1091045001331 Switch I region; other site 1091045001332 G2 box; other site 1091045001333 G3 box; other site 1091045001334 Switch II region; other site 1091045001335 G4 box; other site 1091045001336 G5 box; other site 1091045001337 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1091045001338 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1091045001339 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1091045001340 30S ribosomal protein S7; Validated; Region: PRK05302 1091045001341 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1091045001342 S17 interaction site [polypeptide binding]; other site 1091045001343 S8 interaction site; other site 1091045001344 16S rRNA interaction site [nucleotide binding]; other site 1091045001345 streptomycin interaction site [chemical binding]; other site 1091045001346 23S rRNA interaction site [nucleotide binding]; other site 1091045001347 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1091045001348 potential frameshift: common BLAST hit: gi|295131407|ref|YP_003582070.1| actinobacterial surface-anchored protein domain protein 1091045001349 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1091045001350 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1091045001351 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1091045001352 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1091045001353 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1091045001354 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1091045001355 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1091045001356 G-loop; other site 1091045001357 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1091045001358 DNA binding site [nucleotide binding] 1091045001359 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1091045001360 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1091045001361 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1091045001362 RPB12 interaction site [polypeptide binding]; other site 1091045001363 RPB1 interaction site [polypeptide binding]; other site 1091045001364 RPB10 interaction site [polypeptide binding]; other site 1091045001365 RPB11 interaction site [polypeptide binding]; other site 1091045001366 RPB3 interaction site [polypeptide binding]; other site 1091045001367 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1091045001368 core dimer interface [polypeptide binding]; other site 1091045001369 peripheral dimer interface [polypeptide binding]; other site 1091045001370 L10 interface [polypeptide binding]; other site 1091045001371 L11 interface [polypeptide binding]; other site 1091045001372 putative EF-Tu interaction site [polypeptide binding]; other site 1091045001373 putative EF-G interaction site [polypeptide binding]; other site 1091045001374 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1091045001375 23S rRNA interface [nucleotide binding]; other site 1091045001376 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1091045001377 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1091045001378 mRNA/rRNA interface [nucleotide binding]; other site 1091045001379 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1091045001380 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1091045001381 putative thiostrepton binding site; other site 1091045001382 23S rRNA interface [nucleotide binding]; other site 1091045001383 L7/L12 interface [polypeptide binding]; other site 1091045001384 L25 interface [polypeptide binding]; other site 1091045001385 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1091045001386 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1091045001387 putative homodimer interface [polypeptide binding]; other site 1091045001388 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1091045001389 heterodimer interface [polypeptide binding]; other site 1091045001390 homodimer interface [polypeptide binding]; other site 1091045001391 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1091045001392 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1091045001393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091045001394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045001395 homodimer interface [polypeptide binding]; other site 1091045001396 catalytic residue [active] 1091045001397 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1091045001398 FAD binding domain; Region: FAD_binding_4; pfam01565 1091045001399 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1091045001400 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1091045001401 active site 1091045001402 catalytic site [active] 1091045001403 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1091045001404 active site 1091045001405 catalytic site [active] 1091045001406 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1091045001407 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1091045001408 putative active site [active] 1091045001409 putative catalytic site [active] 1091045001410 putative DNA binding site [nucleotide binding]; other site 1091045001411 putative phosphate binding site [ion binding]; other site 1091045001412 metal binding site A [ion binding]; metal-binding site 1091045001413 putative AP binding site [nucleotide binding]; other site 1091045001414 putative metal binding site B [ion binding]; other site 1091045001415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091045001416 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1091045001417 substrate binding site [chemical binding]; other site 1091045001418 oxyanion hole (OAH) forming residues; other site 1091045001419 trimer interface [polypeptide binding]; other site 1091045001420 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1091045001421 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1091045001422 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1091045001423 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1091045001424 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1091045001425 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1091045001426 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1091045001427 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1091045001428 dimer interface [polypeptide binding]; other site 1091045001429 PYR/PP interface [polypeptide binding]; other site 1091045001430 TPP binding site [chemical binding]; other site 1091045001431 substrate binding site [chemical binding]; other site 1091045001432 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1091045001433 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1091045001434 TPP-binding site [chemical binding]; other site 1091045001435 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1091045001436 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1091045001437 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1091045001438 active site 1091045001439 Zn binding site [ion binding]; other site 1091045001440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045001441 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1091045001442 Walker A/P-loop; other site 1091045001443 ATP binding site [chemical binding]; other site 1091045001444 Q-loop/lid; other site 1091045001445 ABC transporter signature motif; other site 1091045001446 Walker B; other site 1091045001447 D-loop; other site 1091045001448 H-loop/switch region; other site 1091045001449 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1091045001450 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1091045001451 active site 1091045001452 SAM binding site [chemical binding]; other site 1091045001453 homodimer interface [polypeptide binding]; other site 1091045001454 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091045001455 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091045001456 substrate binding pocket [chemical binding]; other site 1091045001457 chain length determination region; other site 1091045001458 substrate-Mg2+ binding site; other site 1091045001459 catalytic residues [active] 1091045001460 aspartate-rich region 1; other site 1091045001461 active site lid residues [active] 1091045001462 aspartate-rich region 2; other site 1091045001463 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1091045001464 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091045001465 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1091045001466 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091045001467 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1091045001468 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1091045001469 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1091045001470 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1091045001471 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1091045001472 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1091045001473 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1091045001474 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045001475 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045001476 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1091045001477 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1091045001478 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1091045001479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091045001480 catalytic loop [active] 1091045001481 iron binding site [ion binding]; other site 1091045001482 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1091045001483 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1091045001484 [4Fe-4S] binding site [ion binding]; other site 1091045001485 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1091045001486 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1091045001487 SLBB domain; Region: SLBB; pfam10531 1091045001488 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1091045001489 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1091045001490 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1091045001491 putative dimer interface [polypeptide binding]; other site 1091045001492 [2Fe-2S] cluster binding site [ion binding]; other site 1091045001493 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1091045001494 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1091045001495 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1091045001496 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1091045001497 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1091045001498 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1091045001499 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1091045001500 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1091045001501 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1091045001502 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091045001503 Walker A/P-loop; other site 1091045001504 ATP binding site [chemical binding]; other site 1091045001505 Q-loop/lid; other site 1091045001506 ABC transporter signature motif; other site 1091045001507 Walker B; other site 1091045001508 D-loop; other site 1091045001509 H-loop/switch region; other site 1091045001510 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1091045001511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045001512 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1091045001513 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045001514 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045001515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045001516 Walker A/P-loop; other site 1091045001517 ATP binding site [chemical binding]; other site 1091045001518 Q-loop/lid; other site 1091045001519 ABC transporter signature motif; other site 1091045001520 Walker B; other site 1091045001521 D-loop; other site 1091045001522 H-loop/switch region; other site 1091045001523 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045001524 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045001525 Walker A/P-loop; other site 1091045001526 ATP binding site [chemical binding]; other site 1091045001527 Q-loop/lid; other site 1091045001528 ABC transporter signature motif; other site 1091045001529 Walker B; other site 1091045001530 D-loop; other site 1091045001531 H-loop/switch region; other site 1091045001532 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1091045001533 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091045001534 H+ Antiporter protein; Region: 2A0121; TIGR00900 1091045001535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001536 putative substrate translocation pore; other site 1091045001537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1091045001538 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1091045001539 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1091045001540 DAK2 domain; Region: Dak2; cl03685 1091045001541 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1091045001542 active pocket/dimerization site; other site 1091045001543 active site 1091045001544 phosphorylation site [posttranslational modification] 1091045001545 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 1091045001546 active site 1091045001547 Zn binding site [ion binding]; other site 1091045001548 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1091045001549 Cation efflux family; Region: Cation_efflux; cl00316 1091045001550 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1091045001551 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1091045001552 NAD binding site [chemical binding]; other site 1091045001553 dimer interface [polypeptide binding]; other site 1091045001554 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091045001555 substrate binding site [chemical binding]; other site 1091045001556 Patatin-like phospholipase; Region: Patatin; pfam01734 1091045001557 active site 1091045001558 nucleophile elbow; other site 1091045001559 Patatin-like phospholipase; Region: Patatin; pfam01734 1091045001560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045001561 UMP phosphatase; Provisional; Region: PRK10444 1091045001562 active site 1091045001563 motif I; other site 1091045001564 motif II; other site 1091045001565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045001566 Right handed beta helix region; Region: Beta_helix; pfam13229 1091045001567 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1091045001568 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091045001569 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1091045001570 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1091045001571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045001572 dimer interface [polypeptide binding]; other site 1091045001573 conserved gate region; other site 1091045001574 putative PBP binding loops; other site 1091045001575 ABC-ATPase subunit interface; other site 1091045001576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045001577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045001578 dimer interface [polypeptide binding]; other site 1091045001579 conserved gate region; other site 1091045001580 putative PBP binding loops; other site 1091045001581 ABC-ATPase subunit interface; other site 1091045001582 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045001583 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1091045001584 Bacterial SH3 domain; Region: SH3_3; pfam08239 1091045001585 Bacterial SH3 domain; Region: SH3_3; cl17532 1091045001586 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091045001587 NlpC/P60 family; Region: NLPC_P60; cl17555 1091045001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1091045001589 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1091045001590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045001591 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091045001592 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1091045001593 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1091045001594 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1091045001595 dimerization interface [polypeptide binding]; other site 1091045001596 putative ATP binding site [chemical binding]; other site 1091045001597 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1091045001598 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1091045001599 active site 1091045001600 tetramer interface [polypeptide binding]; other site 1091045001601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045001602 active site 1091045001603 hypothetical protein; Provisional; Region: PRK07907 1091045001604 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1091045001605 active site 1091045001606 metal binding site [ion binding]; metal-binding site 1091045001607 dimer interface [polypeptide binding]; other site 1091045001608 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1091045001609 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1091045001610 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1091045001611 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1091045001612 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1091045001613 glutamine binding [chemical binding]; other site 1091045001614 catalytic triad [active] 1091045001615 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1091045001616 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1091045001617 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1091045001618 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1091045001619 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1091045001620 dimerization interface [polypeptide binding]; other site 1091045001621 ATP binding site [chemical binding]; other site 1091045001622 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1091045001623 dimerization interface [polypeptide binding]; other site 1091045001624 ATP binding site [chemical binding]; other site 1091045001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045001627 putative substrate translocation pore; other site 1091045001628 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1091045001629 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1091045001630 Zn binding site [ion binding]; other site 1091045001631 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1091045001632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045001633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091045001634 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1091045001635 active site 1091045001636 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1091045001637 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1091045001638 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1091045001639 active site 1091045001640 catalytic triad [active] 1091045001641 oxyanion hole [active] 1091045001642 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1091045001643 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1091045001644 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1091045001645 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1091045001646 putative active site [active] 1091045001647 catalytic triad [active] 1091045001648 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1091045001649 ATP binding site [chemical binding]; other site 1091045001650 active site 1091045001651 substrate binding site [chemical binding]; other site 1091045001652 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1091045001653 peroxiredoxin; Region: AhpC; TIGR03137 1091045001654 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1091045001655 dimer interface [polypeptide binding]; other site 1091045001656 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1091045001657 catalytic triad [active] 1091045001658 peroxidatic and resolving cysteines [active] 1091045001659 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1091045001660 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1091045001661 catalytic residue [active] 1091045001662 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1091045001663 catalytic residues [active] 1091045001664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091045001665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045001666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091045001667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091045001668 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1091045001669 dimerization interface [polypeptide binding]; other site 1091045001670 adenylosuccinate lyase; Region: purB; TIGR00928 1091045001671 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1091045001672 tetramer interface [polypeptide binding]; other site 1091045001673 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1091045001674 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1091045001675 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1091045001676 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1091045001677 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1091045001678 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1091045001679 GDP-binding site [chemical binding]; other site 1091045001680 ACT binding site; other site 1091045001681 IMP binding site; other site 1091045001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091045001683 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091045001684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045001685 DNA-binding site [nucleotide binding]; DNA binding site 1091045001686 FCD domain; Region: FCD; pfam07729 1091045001687 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1091045001688 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1091045001689 putative active site cavity [active] 1091045001690 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1091045001691 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1091045001692 inhibitor site; inhibition site 1091045001693 active site 1091045001694 dimer interface [polypeptide binding]; other site 1091045001695 catalytic residue [active] 1091045001696 putative sialic acid transporter; Provisional; Region: PRK03893 1091045001697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001698 putative substrate translocation pore; other site 1091045001699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001700 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1091045001701 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1091045001702 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1091045001703 G1 box; other site 1091045001704 putative GEF interaction site [polypeptide binding]; other site 1091045001705 GTP/Mg2+ binding site [chemical binding]; other site 1091045001706 Switch I region; other site 1091045001707 G2 box; other site 1091045001708 G3 box; other site 1091045001709 Switch II region; other site 1091045001710 G4 box; other site 1091045001711 G5 box; other site 1091045001712 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1091045001713 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1091045001714 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091045001715 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091045001716 carboxyltransferase (CT) interaction site; other site 1091045001717 biotinylation site [posttranslational modification]; other site 1091045001718 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1091045001719 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1091045001720 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1091045001721 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1091045001722 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1091045001723 active site 1091045001724 catalytic residues [active] 1091045001725 metal binding site [ion binding]; metal-binding site 1091045001726 homodimer binding site [polypeptide binding]; other site 1091045001727 PAS domain; Region: PAS_9; pfam13426 1091045001728 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1091045001729 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1091045001730 active site 1091045001731 intersubunit interface [polypeptide binding]; other site 1091045001732 zinc binding site [ion binding]; other site 1091045001733 Na+ binding site [ion binding]; other site 1091045001734 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091045001735 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091045001736 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1091045001737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091045001738 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1091045001739 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1091045001740 SEC-C motif; Region: SEC-C; pfam02810 1091045001741 hypothetical protein; Provisional; Region: PRK04233 1091045001742 benzoate transport; Region: 2A0115; TIGR00895 1091045001743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001744 putative substrate translocation pore; other site 1091045001745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001746 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1091045001747 Clp amino terminal domain; Region: Clp_N; pfam02861 1091045001748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045001749 Walker A motif; other site 1091045001750 ATP binding site [chemical binding]; other site 1091045001751 Walker B motif; other site 1091045001752 arginine finger; other site 1091045001753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045001754 Walker A motif; other site 1091045001755 ATP binding site [chemical binding]; other site 1091045001756 Walker B motif; other site 1091045001757 arginine finger; other site 1091045001758 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1091045001759 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1091045001760 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1091045001761 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1091045001762 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1091045001763 catalytic residue [active] 1091045001764 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1091045001765 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1091045001766 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1091045001767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091045001768 Histidine kinase; Region: HisKA_3; pfam07730 1091045001769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045001770 ATP binding site [chemical binding]; other site 1091045001771 Mg2+ binding site [ion binding]; other site 1091045001772 G-X-G motif; other site 1091045001773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045001774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045001775 active site 1091045001776 phosphorylation site [posttranslational modification] 1091045001777 intermolecular recognition site; other site 1091045001778 dimerization interface [polypeptide binding]; other site 1091045001779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045001780 DNA binding residues [nucleotide binding] 1091045001781 dimerization interface [polypeptide binding]; other site 1091045001782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045001783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045001784 Walker A/P-loop; other site 1091045001785 ATP binding site [chemical binding]; other site 1091045001786 Q-loop/lid; other site 1091045001787 ABC transporter signature motif; other site 1091045001788 Walker B; other site 1091045001789 D-loop; other site 1091045001790 H-loop/switch region; other site 1091045001791 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091045001792 FtsX-like permease family; Region: FtsX; pfam02687 1091045001793 FtsX-like permease family; Region: FtsX; pfam02687 1091045001794 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1091045001795 nudix motif; other site 1091045001796 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091045001797 Predicted permease [General function prediction only]; Region: COG2985 1091045001798 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1091045001799 TrkA-C domain; Region: TrkA_C; pfam02080 1091045001800 TrkA-C domain; Region: TrkA_C; pfam02080 1091045001801 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1091045001802 potential frameshift: common BLAST hit: gi|295131562|ref|YP_003582225.1| oxidoreductase, zinc-binding dehydrogenase family protein 1091045001803 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1091045001804 active site 1091045001805 catalytic triad [active] 1091045001806 oxyanion hole [active] 1091045001807 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1091045001808 DNA binding residues [nucleotide binding] 1091045001809 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091045001810 putative dimer interface [polypeptide binding]; other site 1091045001811 chaperone protein DnaJ; Provisional; Region: PRK14295 1091045001812 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091045001813 HSP70 interaction site [polypeptide binding]; other site 1091045001814 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1091045001815 Zn binding sites [ion binding]; other site 1091045001816 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1091045001817 dimer interface [polypeptide binding]; other site 1091045001818 GrpE; Region: GrpE; pfam01025 1091045001819 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1091045001820 dimer interface [polypeptide binding]; other site 1091045001821 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1091045001822 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1091045001823 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1091045001824 nucleotide binding site [chemical binding]; other site 1091045001825 NEF interaction site [polypeptide binding]; other site 1091045001826 SBD interface [polypeptide binding]; other site 1091045001827 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1091045001828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091045001829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045001830 active site 1091045001831 phosphorylation site [posttranslational modification] 1091045001832 intermolecular recognition site; other site 1091045001833 dimerization interface [polypeptide binding]; other site 1091045001834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091045001835 DNA binding site [nucleotide binding] 1091045001836 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1091045001837 intersubunit interface [polypeptide binding]; other site 1091045001838 active site 1091045001839 catalytic residue [active] 1091045001840 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 1091045001841 conserved cys residue [active] 1091045001842 FHA domain; Region: FHA; pfam00498 1091045001843 phosphopeptide binding site; other site 1091045001844 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1091045001845 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1091045001846 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1091045001847 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1091045001848 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1091045001849 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1091045001850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045001851 S-adenosylmethionine binding site [chemical binding]; other site 1091045001852 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1091045001853 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091045001854 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1091045001855 active site 1091045001856 catalytic residues [active] 1091045001857 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1091045001858 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1091045001859 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1091045001860 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1091045001861 Amidase; Region: Amidase; cl11426 1091045001862 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1091045001863 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1091045001864 putative active site [active] 1091045001865 homotetrameric interface [polypeptide binding]; other site 1091045001866 metal binding site [ion binding]; metal-binding site 1091045001867 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1091045001868 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1091045001869 active site 1091045001870 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1091045001871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045001872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045001873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045001874 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045001875 Walker A/P-loop; other site 1091045001876 ATP binding site [chemical binding]; other site 1091045001877 Q-loop/lid; other site 1091045001878 ABC transporter signature motif; other site 1091045001879 Walker B; other site 1091045001880 D-loop; other site 1091045001881 H-loop/switch region; other site 1091045001882 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045001883 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045001884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045001885 Walker A/P-loop; other site 1091045001886 ATP binding site [chemical binding]; other site 1091045001887 Q-loop/lid; other site 1091045001888 ABC transporter signature motif; other site 1091045001889 Walker B; other site 1091045001890 D-loop; other site 1091045001891 H-loop/switch region; other site 1091045001892 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1091045001893 EcsC protein family; Region: EcsC; pfam12787 1091045001894 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1091045001895 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1091045001896 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045001897 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1091045001898 Walker A/P-loop; other site 1091045001899 ATP binding site [chemical binding]; other site 1091045001900 Q-loop/lid; other site 1091045001901 ABC transporter signature motif; other site 1091045001902 Walker B; other site 1091045001903 D-loop; other site 1091045001904 H-loop/switch region; other site 1091045001905 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1091045001906 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091045001907 E3 interaction surface; other site 1091045001908 lipoyl attachment site [posttranslational modification]; other site 1091045001909 e3 binding domain; Region: E3_binding; pfam02817 1091045001910 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091045001911 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1091045001912 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1091045001913 alpha subunit interface [polypeptide binding]; other site 1091045001914 TPP binding site [chemical binding]; other site 1091045001915 heterodimer interface [polypeptide binding]; other site 1091045001916 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091045001917 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1091045001918 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1091045001919 TPP-binding site [chemical binding]; other site 1091045001920 tetramer interface [polypeptide binding]; other site 1091045001921 heterodimer interface [polypeptide binding]; other site 1091045001922 phosphorylation loop region [posttranslational modification] 1091045001923 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1091045001924 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1091045001925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045001926 FeS/SAM binding site; other site 1091045001927 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1091045001928 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1091045001929 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1091045001930 active site 1091045001931 metal binding site [ion binding]; metal-binding site 1091045001932 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1091045001933 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1091045001934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045001935 H-loop/switch region; other site 1091045001936 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045001937 WYL domain; Region: WYL; pfam13280 1091045001938 HTH domain; Region: HTH_11; pfam08279 1091045001939 potential frameshift: common BLAST hit: gi|226308065|ref|YP_002768025.1| drug resistance protein 1091045001940 Integrase core domain; Region: rve_3; pfam13683 1091045001941 Lipase (class 2); Region: Lipase_2; pfam01674 1091045001942 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1091045001943 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1091045001944 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1091045001945 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1091045001946 active site 1091045001947 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1091045001948 proposed catalytic triad [active] 1091045001949 active site nucleophile [active] 1091045001950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091045001951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045001952 active site 1091045001953 phosphorylation site [posttranslational modification] 1091045001954 intermolecular recognition site; other site 1091045001955 dimerization interface [polypeptide binding]; other site 1091045001956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091045001957 DNA binding site [nucleotide binding] 1091045001958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091045001959 HAMP domain; Region: HAMP; pfam00672 1091045001960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091045001961 dimer interface [polypeptide binding]; other site 1091045001962 phosphorylation site [posttranslational modification] 1091045001963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045001964 ATP binding site [chemical binding]; other site 1091045001965 Mg2+ binding site [ion binding]; other site 1091045001966 G-X-G motif; other site 1091045001967 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1091045001968 catalytic nucleophile [active] 1091045001969 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1091045001970 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1091045001971 active site 1091045001972 metal binding site [ion binding]; metal-binding site 1091045001973 nudix motif; other site 1091045001974 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091045001975 YCII-related domain; Region: YCII; cl00999 1091045001976 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1091045001977 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1091045001978 active site 1091045001979 FMN binding site [chemical binding]; other site 1091045001980 substrate binding site [chemical binding]; other site 1091045001981 homotetramer interface [polypeptide binding]; other site 1091045001982 catalytic residue [active] 1091045001983 metabolite-proton symporter; Region: 2A0106; TIGR00883 1091045001984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045001985 putative substrate translocation pore; other site 1091045001986 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1091045001987 ATP cone domain; Region: ATP-cone; pfam03477 1091045001988 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1091045001989 active site 1091045001990 dimer interface [polypeptide binding]; other site 1091045001991 catalytic residues [active] 1091045001992 effector binding site; other site 1091045001993 R2 peptide binding site; other site 1091045001994 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1091045001995 dimer interface [polypeptide binding]; other site 1091045001996 putative radical transfer pathway; other site 1091045001997 diiron center [ion binding]; other site 1091045001998 tyrosyl radical; other site 1091045001999 Predicted membrane protein [Function unknown]; Region: COG3428 1091045002000 Bacterial PH domain; Region: DUF304; pfam03703 1091045002001 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1091045002002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1091045002003 nucleotide binding site [chemical binding]; other site 1091045002004 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1091045002005 ornithine carbamoyltransferase; Validated; Region: PRK02102 1091045002006 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1091045002007 arginine-tRNA ligase; Region: PLN02286 1091045002008 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1091045002009 active site 1091045002010 HIGH motif; other site 1091045002011 KMSK motif region; other site 1091045002012 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1091045002013 tRNA binding surface [nucleotide binding]; other site 1091045002014 anticodon binding site; other site 1091045002015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091045002016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091045002017 active site 1091045002018 catalytic tetrad [active] 1091045002019 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1091045002020 putative active site [active] 1091045002021 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1091045002022 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1091045002023 active site 1091045002024 dimer interface [polypeptide binding]; other site 1091045002025 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1091045002026 dimer interface [polypeptide binding]; other site 1091045002027 active site 1091045002028 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1091045002029 active site 1091045002030 intersubunit interface [polypeptide binding]; other site 1091045002031 catalytic residue [active] 1091045002032 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1091045002033 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1091045002034 dimerization interface [polypeptide binding]; other site 1091045002035 DPS ferroxidase diiron center [ion binding]; other site 1091045002036 ion pore; other site 1091045002037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045002038 ATP binding site [chemical binding]; other site 1091045002039 putative Mg++ binding site [ion binding]; other site 1091045002040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045002041 nucleotide binding region [chemical binding]; other site 1091045002042 ATP-binding site [chemical binding]; other site 1091045002043 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1091045002044 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1091045002045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045002046 FeS/SAM binding site; other site 1091045002047 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1091045002048 ATP cone domain; Region: ATP-cone; pfam03477 1091045002049 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1091045002050 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1091045002051 active site 1091045002052 Zn binding site [ion binding]; other site 1091045002053 glycine loop; other site 1091045002054 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1091045002055 substrate binding site [chemical binding]; other site 1091045002056 Cutinase; Region: Cutinase; pfam01083 1091045002057 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1091045002058 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091045002059 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1091045002060 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1091045002061 NodB motif; other site 1091045002062 active site 1091045002063 catalytic site [active] 1091045002064 metal binding site [ion binding]; metal-binding site 1091045002065 TIGR03943 family protein; Region: TIGR03943 1091045002066 Predicted permease; Region: DUF318; cl17795 1091045002067 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1091045002068 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1091045002069 NodB motif; other site 1091045002070 active site 1091045002071 catalytic site [active] 1091045002072 metal binding site [ion binding]; metal-binding site 1091045002073 integral membrane protein MviN; Region: mviN; TIGR01695 1091045002074 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1091045002075 aspartate kinase; Reviewed; Region: PRK06635 1091045002076 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1091045002077 putative nucleotide binding site [chemical binding]; other site 1091045002078 putative catalytic residues [active] 1091045002079 putative Mg ion binding site [ion binding]; other site 1091045002080 putative aspartate binding site [chemical binding]; other site 1091045002081 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1091045002082 putative allosteric regulatory site; other site 1091045002083 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1091045002084 putative allosteric regulatory residue; other site 1091045002085 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1091045002086 Transglycosylase; Region: Transgly; pfam00912 1091045002087 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1091045002088 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1091045002089 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1091045002090 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1091045002091 putative active site [active] 1091045002092 putative metal binding site [ion binding]; other site 1091045002093 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1091045002094 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1091045002095 proposed catalytic triad [active] 1091045002096 conserved cys residue [active] 1091045002097 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1091045002098 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1091045002099 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1091045002100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1091045002101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002102 dimer interface [polypeptide binding]; other site 1091045002103 conserved gate region; other site 1091045002104 putative PBP binding loops; other site 1091045002105 ABC-ATPase subunit interface; other site 1091045002106 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1091045002107 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1091045002108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002109 dimer interface [polypeptide binding]; other site 1091045002110 conserved gate region; other site 1091045002111 putative PBP binding loops; other site 1091045002112 ABC-ATPase subunit interface; other site 1091045002113 potential frameshift: common BLAST hit: gi|295131676|ref|YP_003582339.1| oligopeptide transport ATP-binding protein OppD 1091045002114 potential frameshift: common BLAST hit: gi|295131677|ref|YP_003582340.1| ABC transporter, ATP-binding protein 1091045002115 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1091045002116 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1091045002117 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1091045002118 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1091045002119 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091045002120 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1091045002121 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1091045002122 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1091045002123 urocanate hydratase; Provisional; Region: PRK05414 1091045002124 allantoate amidohydrolase; Reviewed; Region: PRK09290 1091045002125 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1091045002126 active site 1091045002127 metal binding site [ion binding]; metal-binding site 1091045002128 dimer interface [polypeptide binding]; other site 1091045002129 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1091045002130 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091045002131 active site 1091045002132 imidazolonepropionase; Provisional; Region: PRK14085 1091045002133 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1091045002134 active site 1091045002135 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1091045002136 active sites [active] 1091045002137 tetramer interface [polypeptide binding]; other site 1091045002138 helicase Cas3; Provisional; Region: PRK09694 1091045002139 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1091045002140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091045002141 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1091045002142 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1091045002143 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1091045002144 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1091045002145 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1091045002146 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1091045002147 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1091045002148 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1091045002149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045002150 Walker B; other site 1091045002151 H-loop/switch region; other site 1091045002152 NAD-dependent deacetylase; Provisional; Region: PRK00481 1091045002153 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1091045002154 NAD+ binding site [chemical binding]; other site 1091045002155 substrate binding site [chemical binding]; other site 1091045002156 Zn binding site [ion binding]; other site 1091045002157 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1091045002158 Bacterial SH3 domain; Region: SH3_3; pfam08239 1091045002159 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1091045002160 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1091045002161 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1091045002162 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1091045002163 potassium/proton antiporter; Reviewed; Region: PRK05326 1091045002164 TrkA-C domain; Region: TrkA_C; pfam02080 1091045002165 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1091045002166 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1091045002167 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091045002168 nucleoside/Zn binding site; other site 1091045002169 dimer interface [polypeptide binding]; other site 1091045002170 catalytic motif [active] 1091045002171 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1091045002172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045002173 active site 1091045002174 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1091045002175 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1091045002176 active site 1091045002177 catalytic site [active] 1091045002178 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1091045002179 putative deacylase active site [active] 1091045002180 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1091045002181 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1091045002182 K+ potassium transporter; Region: K_trans; pfam02705 1091045002183 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1091045002184 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1091045002185 catalytic triad [active] 1091045002186 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1091045002187 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1091045002188 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045002189 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045002190 DNA binding site [nucleotide binding] 1091045002191 domain linker motif; other site 1091045002192 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1091045002193 ligand binding site [chemical binding]; other site 1091045002194 dimerization interface (open form) [polypeptide binding]; other site 1091045002195 dimerization interface (closed form) [polypeptide binding]; other site 1091045002196 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1091045002197 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1091045002198 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1091045002199 putative transporter; Provisional; Region: PRK10484 1091045002200 Na binding site [ion binding]; other site 1091045002201 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1091045002202 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1091045002203 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1091045002204 NAD(P) binding site [chemical binding]; other site 1091045002205 argininosuccinate synthase; Validated; Region: PRK05370 1091045002206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045002207 putative substrate translocation pore; other site 1091045002208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045002209 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1091045002210 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1091045002211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1091045002212 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1091045002213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045002214 active site 1091045002215 motif I; other site 1091045002216 motif II; other site 1091045002217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045002218 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1091045002219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091045002220 non-specific DNA binding site [nucleotide binding]; other site 1091045002221 salt bridge; other site 1091045002222 sequence-specific DNA binding site [nucleotide binding]; other site 1091045002223 Cupin domain; Region: Cupin_2; pfam07883 1091045002224 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1091045002225 B3/4 domain; Region: B3_4; pfam03483 1091045002226 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1091045002227 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1091045002228 Na binding site [ion binding]; other site 1091045002229 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1091045002230 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 1091045002231 oxidoreductase; Provisional; Region: PRK10015 1091045002232 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1091045002233 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1091045002234 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1091045002235 Ligand binding site [chemical binding]; other site 1091045002236 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1091045002237 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1091045002238 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1091045002239 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091045002240 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091045002241 active site 1091045002242 Bacterial transcriptional regulator; Region: IclR; pfam01614 1091045002243 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1091045002244 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1091045002245 nucleotide binding site/active site [active] 1091045002246 HIT family signature motif; other site 1091045002247 catalytic residue [active] 1091045002248 seryl-tRNA synthetase; Provisional; Region: PRK05431 1091045002249 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1091045002250 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1091045002251 dimer interface [polypeptide binding]; other site 1091045002252 active site 1091045002253 motif 1; other site 1091045002254 motif 2; other site 1091045002255 motif 3; other site 1091045002256 PRC-barrel domain; Region: PRC; pfam05239 1091045002257 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1091045002258 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1091045002259 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1091045002260 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1091045002261 FAD binding pocket [chemical binding]; other site 1091045002262 FAD binding motif [chemical binding]; other site 1091045002263 phosphate binding motif [ion binding]; other site 1091045002264 NAD binding pocket [chemical binding]; other site 1091045002265 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1091045002266 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1091045002267 Ferritin-like domain; Region: Ferritin; pfam00210 1091045002268 ferroxidase diiron center [ion binding]; other site 1091045002269 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1091045002270 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1091045002271 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1091045002272 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1091045002273 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1091045002274 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1091045002275 dimer interface [polypeptide binding]; other site 1091045002276 ssDNA binding site [nucleotide binding]; other site 1091045002277 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091045002278 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1091045002279 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091045002280 active site residue [active] 1091045002281 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045002282 active site 1091045002283 phosphorylation site [posttranslational modification] 1091045002284 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1091045002285 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1091045002286 active site 1091045002287 P-loop; other site 1091045002288 phosphorylation site [posttranslational modification] 1091045002289 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1091045002290 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1091045002291 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1091045002292 acyl-activating enzyme (AAE) consensus motif; other site 1091045002293 putative AMP binding site [chemical binding]; other site 1091045002294 putative active site [active] 1091045002295 putative CoA binding site [chemical binding]; other site 1091045002296 endonuclease IV; Provisional; Region: PRK01060 1091045002297 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1091045002298 AP (apurinic/apyrimidinic) site pocket; other site 1091045002299 DNA interaction; other site 1091045002300 Metal-binding active site; metal-binding site 1091045002301 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1091045002302 classical (c) SDRs; Region: SDR_c; cd05233 1091045002303 NAD(P) binding site [chemical binding]; other site 1091045002304 active site 1091045002305 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091045002306 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091045002307 putative acyl-acceptor binding pocket; other site 1091045002308 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1091045002309 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1091045002310 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1091045002311 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1091045002312 G5 domain; Region: G5; pfam07501 1091045002313 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1091045002314 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091045002315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091045002316 metal-binding site [ion binding] 1091045002317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091045002318 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091045002319 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091045002320 metal-binding site [ion binding] 1091045002321 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1091045002322 putative homodimer interface [polypeptide binding]; other site 1091045002323 putative homotetramer interface [polypeptide binding]; other site 1091045002324 putative allosteric switch controlling residues; other site 1091045002325 putative metal binding site [ion binding]; other site 1091045002326 putative homodimer-homodimer interface [polypeptide binding]; other site 1091045002327 replicative DNA helicase; Region: DnaB; TIGR00665 1091045002328 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1091045002329 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1091045002330 Walker A motif; other site 1091045002331 ATP binding site [chemical binding]; other site 1091045002332 Walker B motif; other site 1091045002333 DNA binding loops [nucleotide binding] 1091045002334 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1091045002335 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1091045002336 putative NAD(P) binding site [chemical binding]; other site 1091045002337 dimer interface [polypeptide binding]; other site 1091045002338 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1091045002339 active site 1091045002340 DNA binding site [nucleotide binding] 1091045002341 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1091045002342 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1091045002343 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1091045002344 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1091045002345 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1091045002346 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1091045002347 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1091045002348 dimerization interface [polypeptide binding]; other site 1091045002349 ligand binding site [chemical binding]; other site 1091045002350 NADP binding site [chemical binding]; other site 1091045002351 catalytic site [active] 1091045002352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091045002353 MarR family; Region: MarR; pfam01047 1091045002354 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1091045002355 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1091045002356 Cl- selectivity filter; other site 1091045002357 Cl- binding residues [ion binding]; other site 1091045002358 pore gating glutamate residue; other site 1091045002359 dimer interface [polypeptide binding]; other site 1091045002360 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091045002361 MarR family; Region: MarR_2; pfam12802 1091045002362 YceI-like domain; Region: YceI; smart00867 1091045002363 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1091045002364 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1091045002365 active site 1091045002366 metal binding site [ion binding]; metal-binding site 1091045002367 Predicted ATPases [General function prediction only]; Region: COG1106 1091045002368 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1091045002369 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1091045002370 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1091045002371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045002372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045002373 WHG domain; Region: WHG; pfam13305 1091045002374 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1091045002375 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1091045002376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045002377 catalytic residue [active] 1091045002378 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1091045002379 putative deacylase active site [active] 1091045002380 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091045002381 NAD synthetase; Reviewed; Region: nadE; PRK02628 1091045002382 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1091045002383 multimer interface [polypeptide binding]; other site 1091045002384 active site 1091045002385 catalytic triad [active] 1091045002386 protein interface 1 [polypeptide binding]; other site 1091045002387 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1091045002388 homodimer interface [polypeptide binding]; other site 1091045002389 NAD binding pocket [chemical binding]; other site 1091045002390 ATP binding pocket [chemical binding]; other site 1091045002391 Mg binding site [ion binding]; other site 1091045002392 active-site loop [active] 1091045002393 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1091045002394 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1091045002395 active site 1091045002396 ADP/pyrophosphate binding site [chemical binding]; other site 1091045002397 dimerization interface [polypeptide binding]; other site 1091045002398 allosteric effector site; other site 1091045002399 fructose-1,6-bisphosphate binding site; other site 1091045002400 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1091045002401 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1091045002402 hexamer interface [polypeptide binding]; other site 1091045002403 ligand binding site [chemical binding]; other site 1091045002404 putative active site [active] 1091045002405 NAD(P) binding site [chemical binding]; other site 1091045002406 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1091045002407 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1091045002408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1091045002409 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091045002410 Bacterial SH3 domain; Region: SH3_3; pfam08239 1091045002411 Bacterial SH3 domain; Region: SH3_3; pfam08239 1091045002412 Bacterial SH3 domain; Region: SH3_4; pfam06347 1091045002413 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1091045002414 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1091045002415 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1091045002416 dimer interface [polypeptide binding]; other site 1091045002417 Citrate synthase; Region: Citrate_synt; pfam00285 1091045002418 active site 1091045002419 citrylCoA binding site [chemical binding]; other site 1091045002420 NADH binding [chemical binding]; other site 1091045002421 cationic pore residues; other site 1091045002422 oxalacetate/citrate binding site [chemical binding]; other site 1091045002423 coenzyme A binding site [chemical binding]; other site 1091045002424 catalytic triad [active] 1091045002425 adenosine deaminase; Provisional; Region: PRK09358 1091045002426 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1091045002427 active site 1091045002428 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1091045002429 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1091045002430 hexamer interface [polypeptide binding]; other site 1091045002431 ligand binding site [chemical binding]; other site 1091045002432 putative active site [active] 1091045002433 NAD(P) binding site [chemical binding]; other site 1091045002434 potential frameshift: common BLAST hit: gi|50843712|ref|YP_056939.1| AsnC family transcriptional regulator 1091045002435 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1091045002436 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091045002437 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1091045002438 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1091045002439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045002440 catalytic residue [active] 1091045002441 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1091045002442 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1091045002443 B12 binding site [chemical binding]; other site 1091045002444 MutL protein; Region: MutL; pfam13941 1091045002445 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1091045002446 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1091045002447 active site 1091045002448 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091045002449 dimer interface [polypeptide binding]; other site 1091045002450 substrate binding site [chemical binding]; other site 1091045002451 catalytic residue [active] 1091045002452 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1091045002453 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1091045002454 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1091045002455 alanine racemase; Reviewed; Region: alr; PRK00053 1091045002456 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1091045002457 active site 1091045002458 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091045002459 dimer interface [polypeptide binding]; other site 1091045002460 substrate binding site [chemical binding]; other site 1091045002461 catalytic residues [active] 1091045002462 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1091045002463 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1091045002464 active site 1091045002465 substrate binding site [chemical binding]; other site 1091045002466 metal binding site [ion binding]; metal-binding site 1091045002467 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1091045002468 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1091045002469 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1091045002470 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1091045002471 active site 1091045002472 Substrate binding site; other site 1091045002473 Mg++ binding site; other site 1091045002474 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1091045002475 putative active site [active] 1091045002476 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1091045002477 Class II fumarases; Region: Fumarase_classII; cd01362 1091045002478 active site 1091045002479 tetramer interface [polypeptide binding]; other site 1091045002480 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045002481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002482 dimer interface [polypeptide binding]; other site 1091045002483 conserved gate region; other site 1091045002484 putative PBP binding loops; other site 1091045002485 ABC-ATPase subunit interface; other site 1091045002486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002487 dimer interface [polypeptide binding]; other site 1091045002488 conserved gate region; other site 1091045002489 putative PBP binding loops; other site 1091045002490 ABC-ATPase subunit interface; other site 1091045002491 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1091045002492 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045002493 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045002494 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045002495 DNA binding site [nucleotide binding] 1091045002496 domain linker motif; other site 1091045002497 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1091045002498 putative dimerization interface [polypeptide binding]; other site 1091045002499 putative ligand binding site [chemical binding]; other site 1091045002500 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1091045002501 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091045002502 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091045002503 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1091045002504 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1091045002505 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1091045002506 active site 1091045002507 NTP binding site [chemical binding]; other site 1091045002508 metal binding triad [ion binding]; metal-binding site 1091045002509 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1091045002510 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091045002511 Zn2+ binding site [ion binding]; other site 1091045002512 Mg2+ binding site [ion binding]; other site 1091045002513 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1091045002514 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091045002515 active site 1091045002516 ATP binding site [chemical binding]; other site 1091045002517 substrate binding site [chemical binding]; other site 1091045002518 activation loop (A-loop); other site 1091045002519 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1091045002520 glycerol kinase; Provisional; Region: glpK; PRK00047 1091045002521 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1091045002522 N- and C-terminal domain interface [polypeptide binding]; other site 1091045002523 active site 1091045002524 MgATP binding site [chemical binding]; other site 1091045002525 catalytic site [active] 1091045002526 metal binding site [ion binding]; metal-binding site 1091045002527 putative homotetramer interface [polypeptide binding]; other site 1091045002528 glycerol binding site [chemical binding]; other site 1091045002529 homodimer interface [polypeptide binding]; other site 1091045002530 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1091045002531 amphipathic channel; other site 1091045002532 Asn-Pro-Ala signature motifs; other site 1091045002533 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1091045002534 Helix-turn-helix domain; Region: HTH_28; pfam13518 1091045002535 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1091045002536 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091045002537 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091045002538 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1091045002539 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1091045002540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091045002541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045002542 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1091045002543 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1091045002544 probable active site [active] 1091045002545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045002546 putative substrate translocation pore; other site 1091045002547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091045002548 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091045002549 substrate binding pocket [chemical binding]; other site 1091045002550 OsmC-like protein; Region: OsmC; pfam02566 1091045002551 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091045002552 catalytic residues [active] 1091045002553 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 1091045002554 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091045002555 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1091045002556 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1091045002557 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1091045002558 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1091045002559 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1091045002560 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1091045002561 TPP-binding site [chemical binding]; other site 1091045002562 dimer interface [polypeptide binding]; other site 1091045002563 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091045002564 PYR/PP interface [polypeptide binding]; other site 1091045002565 dimer interface [polypeptide binding]; other site 1091045002566 TPP binding site [chemical binding]; other site 1091045002567 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091045002568 ribulokinase; Provisional; Region: PRK04123 1091045002569 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1091045002570 N- and C-terminal domain interface [polypeptide binding]; other site 1091045002571 active site 1091045002572 MgATP binding site [chemical binding]; other site 1091045002573 catalytic site [active] 1091045002574 metal binding site [ion binding]; metal-binding site 1091045002575 carbohydrate binding site [chemical binding]; other site 1091045002576 homodimer interface [polypeptide binding]; other site 1091045002577 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1091045002578 active site 1091045002579 metal binding site [ion binding]; metal-binding site 1091045002580 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1091045002581 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1091045002582 N- and C-terminal domain interface [polypeptide binding]; other site 1091045002583 active site 1091045002584 MgATP binding site [chemical binding]; other site 1091045002585 catalytic site [active] 1091045002586 metal binding site [ion binding]; metal-binding site 1091045002587 putative carbohydrate binding site [chemical binding]; other site 1091045002588 putative homodimer interface [polypeptide binding]; other site 1091045002589 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1091045002590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045002591 active site 1091045002592 motif I; other site 1091045002593 motif II; other site 1091045002594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045002595 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1091045002596 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1091045002597 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1091045002598 intersubunit interface [polypeptide binding]; other site 1091045002599 active site 1091045002600 Zn2+ binding site [ion binding]; other site 1091045002601 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1091045002602 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 1091045002603 intersubunit interface [polypeptide binding]; other site 1091045002604 active site 1091045002605 Zn2+ binding site [ion binding]; other site 1091045002606 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1091045002607 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1091045002608 putative ligand binding site [chemical binding]; other site 1091045002609 putative NAD binding site [chemical binding]; other site 1091045002610 catalytic site [active] 1091045002611 potential frameshift: common BLAST hit: gi|292653834|ref|YP_003533732.1| sugar kinase, FGGY family, putative 1091045002612 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1091045002613 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1091045002614 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1091045002615 mannonate dehydratase; Provisional; Region: PRK03906 1091045002616 mannonate dehydratase; Region: uxuA; TIGR00695 1091045002617 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1091045002618 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1091045002619 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1091045002620 glucuronate isomerase; Reviewed; Region: PRK02925 1091045002621 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1091045002622 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045002623 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045002624 DNA binding site [nucleotide binding] 1091045002625 domain linker motif; other site 1091045002626 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1091045002627 dimerization interface [polypeptide binding]; other site 1091045002628 ligand binding site [chemical binding]; other site 1091045002629 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1091045002630 MFS/sugar transport protein; Region: MFS_2; pfam13347 1091045002631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045002632 putative alpha-glucosidase; Provisional; Region: PRK10658 1091045002633 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1091045002634 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1091045002635 putative active site [active] 1091045002636 putative catalytic site [active] 1091045002637 beta-D-glucuronidase; Provisional; Region: PRK10150 1091045002638 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1091045002639 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1091045002640 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1091045002641 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1091045002642 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1091045002643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091045002644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045002645 homodimer interface [polypeptide binding]; other site 1091045002646 catalytic residue [active] 1091045002647 potential frameshift: common BLAST hit: gi|50843773|ref|YP_057000.1| D-alanine--D-alanine ligase B 1091045002648 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1091045002649 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1091045002650 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1091045002651 ParB-like nuclease domain; Region: ParB; smart00470 1091045002652 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091045002653 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091045002654 P-loop; other site 1091045002655 Magnesium ion binding site [ion binding]; other site 1091045002656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091045002657 Magnesium ion binding site [ion binding]; other site 1091045002658 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1091045002659 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1091045002660 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1091045002661 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091045002662 catalytic residue [active] 1091045002663 FemAB family; Region: FemAB; pfam02388 1091045002664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1091045002665 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1091045002666 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1091045002667 G-X-X-G motif; other site 1091045002668 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1091045002669 RxxxH motif; other site 1091045002670 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1091045002671 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1091045002672 Haemolytic domain; Region: Haemolytic; pfam01809 1091045002673 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1091045002674 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1091045002675 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1091045002676 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1091045002677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045002678 Walker A motif; other site 1091045002679 ATP binding site [chemical binding]; other site 1091045002680 Walker B motif; other site 1091045002681 arginine finger; other site 1091045002682 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1091045002683 DnaA box-binding interface [nucleotide binding]; other site 1091045002684 DNA polymerase III subunit beta; Validated; Region: PRK07761 1091045002685 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1091045002686 putative DNA binding surface [nucleotide binding]; other site 1091045002687 dimer interface [polypeptide binding]; other site 1091045002688 beta-clamp/clamp loader binding surface; other site 1091045002689 beta-clamp/translesion DNA polymerase binding surface; other site 1091045002690 recombination protein F; Reviewed; Region: recF; PRK00064 1091045002691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045002692 Walker A/P-loop; other site 1091045002693 ATP binding site [chemical binding]; other site 1091045002694 Q-loop/lid; other site 1091045002695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045002696 ABC transporter signature motif; other site 1091045002697 Walker B; other site 1091045002698 D-loop; other site 1091045002699 H-loop/switch region; other site 1091045002700 Protein of unknown function (DUF721); Region: DUF721; cl02324 1091045002701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045002702 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045002703 H-loop/switch region; other site 1091045002704 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1091045002705 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1091045002706 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1091045002707 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1091045002708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045002709 Mg2+ binding site [ion binding]; other site 1091045002710 G-X-G motif; other site 1091045002711 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1091045002712 anchoring element; other site 1091045002713 dimer interface [polypeptide binding]; other site 1091045002714 ATP binding site [chemical binding]; other site 1091045002715 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1091045002716 active site 1091045002717 putative metal-binding site [ion binding]; other site 1091045002718 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1091045002719 DNA gyrase subunit A; Validated; Region: PRK05560 1091045002720 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1091045002721 CAP-like domain; other site 1091045002722 active site 1091045002723 primary dimer interface [polypeptide binding]; other site 1091045002724 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091045002725 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091045002726 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091045002727 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091045002728 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091045002729 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1091045002730 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1091045002731 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1091045002732 NAD binding site [chemical binding]; other site 1091045002733 dimer interface [polypeptide binding]; other site 1091045002734 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091045002735 substrate binding site [chemical binding]; other site 1091045002736 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045002737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045002738 DNA binding site [nucleotide binding] 1091045002739 domain linker motif; other site 1091045002740 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1091045002741 dimerization interface [polypeptide binding]; other site 1091045002742 putative ligand binding site [chemical binding]; other site 1091045002743 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1091045002744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1091045002745 Walker A/P-loop; other site 1091045002746 ATP binding site [chemical binding]; other site 1091045002747 Q-loop/lid; other site 1091045002748 ABC transporter signature motif; other site 1091045002749 Walker B; other site 1091045002750 D-loop; other site 1091045002751 H-loop/switch region; other site 1091045002752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1091045002753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1091045002754 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1091045002755 TM-ABC transporter signature motif; other site 1091045002756 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1091045002757 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1091045002758 ligand binding site [chemical binding]; other site 1091045002759 dimerization interface [polypeptide binding]; other site 1091045002760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091045002761 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1091045002762 substrate binding site [chemical binding]; other site 1091045002763 dimer interface [polypeptide binding]; other site 1091045002764 ATP binding site [chemical binding]; other site 1091045002765 D-ribose pyranase; Provisional; Region: PRK11797 1091045002766 potential frameshift: common BLAST hit: gi|297625277|ref|YP_003687040.1| glycerol-3-phosphate dehydrogenase [NAD(P)+] 1091045002767 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1091045002768 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 1091045002769 putative N- and C-terminal domain interface [polypeptide binding]; other site 1091045002770 putative active site [active] 1091045002771 MgATP binding site [chemical binding]; other site 1091045002772 catalytic site [active] 1091045002773 metal binding site [ion binding]; metal-binding site 1091045002774 putative carbohydrate binding site [chemical binding]; other site 1091045002775 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045002776 active site 1091045002777 phosphorylation site [posttranslational modification] 1091045002778 potential frameshift: common BLAST hit: gi|365972941|ref|YP_004954500.1| PTS system galactitol-specific transporter subunit IIC 1091045002779 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1091045002780 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1091045002781 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1091045002782 active site 1091045002783 P-loop; other site 1091045002784 phosphorylation site [posttranslational modification] 1091045002785 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1091045002786 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091045002787 NAD(P) binding site [chemical binding]; other site 1091045002788 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1091045002789 PRD domain; Region: PRD; pfam00874 1091045002790 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045002791 active site 1091045002792 phosphorylation site [posttranslational modification] 1091045002793 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1091045002794 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1091045002795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1091045002796 active site 1091045002797 motif I; other site 1091045002798 motif II; other site 1091045002799 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1091045002800 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1091045002801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1091045002802 potential frameshift: common BLAST hit: gi|50841527|ref|YP_054754.1| putative aminotransferase 1091045002803 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1091045002804 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1091045002805 active site 1091045002806 nucleophile elbow; other site 1091045002807 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091045002808 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1091045002809 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1091045002810 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1091045002811 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091045002812 Walker A motif; other site 1091045002813 ATP binding site [chemical binding]; other site 1091045002814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091045002815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091045002816 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1091045002817 H+ Antiporter protein; Region: 2A0121; TIGR00900 1091045002818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045002819 putative substrate translocation pore; other site 1091045002820 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1091045002821 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1091045002822 Potassium binding sites [ion binding]; other site 1091045002823 Cesium cation binding sites [ion binding]; other site 1091045002824 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1091045002825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091045002826 FtsX-like permease family; Region: FtsX; pfam02687 1091045002827 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091045002828 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045002829 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045002830 Walker A/P-loop; other site 1091045002831 ATP binding site [chemical binding]; other site 1091045002832 Q-loop/lid; other site 1091045002833 ABC transporter signature motif; other site 1091045002834 Walker B; other site 1091045002835 D-loop; other site 1091045002836 H-loop/switch region; other site 1091045002837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045002838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045002839 active site 1091045002840 phosphorylation site [posttranslational modification] 1091045002841 intermolecular recognition site; other site 1091045002842 dimerization interface [polypeptide binding]; other site 1091045002843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045002844 DNA binding residues [nucleotide binding] 1091045002845 dimerization interface [polypeptide binding]; other site 1091045002846 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045002847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002848 dimer interface [polypeptide binding]; other site 1091045002849 conserved gate region; other site 1091045002850 putative PBP binding loops; other site 1091045002851 ABC-ATPase subunit interface; other site 1091045002852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002853 dimer interface [polypeptide binding]; other site 1091045002854 conserved gate region; other site 1091045002855 putative PBP binding loops; other site 1091045002856 ABC-ATPase subunit interface; other site 1091045002857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1091045002858 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045002859 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1091045002860 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1091045002861 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1091045002862 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1091045002863 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1091045002864 NAD binding site [chemical binding]; other site 1091045002865 sugar binding site [chemical binding]; other site 1091045002866 divalent metal binding site [ion binding]; other site 1091045002867 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091045002868 dimer interface [polypeptide binding]; other site 1091045002869 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1091045002870 active site 1091045002871 catalytic site [active] 1091045002872 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1091045002873 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1091045002874 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1091045002875 Sulfatase; Region: Sulfatase; cl17466 1091045002876 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1091045002877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045002878 motif II; other site 1091045002879 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1091045002880 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1091045002881 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1091045002882 active site 1091045002883 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091045002884 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1091045002885 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cd00287 1091045002886 ATP binding site [chemical binding]; other site 1091045002887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1091045002888 Histidine kinase; Region: HisKA_3; pfam07730 1091045002889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045002890 ATP binding site [chemical binding]; other site 1091045002891 Mg2+ binding site [ion binding]; other site 1091045002892 G-X-G motif; other site 1091045002893 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1091045002894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091045002895 NAD(P) binding site [chemical binding]; other site 1091045002896 active site 1091045002897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045002898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045002899 MMPL family; Region: MMPL; pfam03176 1091045002900 MMPL family; Region: MMPL; pfam03176 1091045002901 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1091045002902 Predicted membrane protein [Function unknown]; Region: COG1511 1091045002903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045002904 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045002905 Walker A/P-loop; other site 1091045002906 ATP binding site [chemical binding]; other site 1091045002907 Q-loop/lid; other site 1091045002908 ABC transporter signature motif; other site 1091045002909 Walker B; other site 1091045002910 D-loop; other site 1091045002911 H-loop/switch region; other site 1091045002912 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091045002913 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1091045002914 tetramerization interface [polypeptide binding]; other site 1091045002915 NAD(P) binding site [chemical binding]; other site 1091045002916 catalytic residues [active] 1091045002917 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1091045002918 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1091045002919 putative ion selectivity filter; other site 1091045002920 putative pore gating glutamate residue; other site 1091045002921 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1091045002922 homodimer interface [polypeptide binding]; other site 1091045002923 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1091045002924 active site pocket [active] 1091045002925 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1091045002926 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1091045002927 DNA binding residues [nucleotide binding] 1091045002928 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1091045002929 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1091045002930 MarR family; Region: MarR_2; pfam12802 1091045002931 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1091045002932 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091045002933 potential frameshift: common BLAST hit: gi|295129616|ref|YP_003580279.1| carbohydrate ABC transporter, carbohydrate-binding protein 1091045002934 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1091045002935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002936 dimer interface [polypeptide binding]; other site 1091045002937 conserved gate region; other site 1091045002938 putative PBP binding loops; other site 1091045002939 ABC-ATPase subunit interface; other site 1091045002940 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045002941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045002942 dimer interface [polypeptide binding]; other site 1091045002943 conserved gate region; other site 1091045002944 putative PBP binding loops; other site 1091045002945 ABC-ATPase subunit interface; other site 1091045002946 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045002947 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045002948 DNA binding site [nucleotide binding] 1091045002949 domain linker motif; other site 1091045002950 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1091045002951 ligand binding site [chemical binding]; other site 1091045002952 dimerization interface (open form) [polypeptide binding]; other site 1091045002953 dimerization interface (closed form) [polypeptide binding]; other site 1091045002954 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1091045002955 potential frameshift: common BLAST hit: gi|256394794|ref|YP_003116358.1| ricin B lectin 1091045002956 6-phosphofructokinase; Provisional; Region: PRK03202 1091045002957 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1091045002958 active site 1091045002959 ADP/pyrophosphate binding site [chemical binding]; other site 1091045002960 dimerization interface [polypeptide binding]; other site 1091045002961 allosteric effector site; other site 1091045002962 fructose-1,6-bisphosphate binding site; other site 1091045002963 Predicted transcriptional regulator [Transcription]; Region: COG2345 1091045002964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091045002965 putative DNA binding site [nucleotide binding]; other site 1091045002966 putative Zn2+ binding site [ion binding]; other site 1091045002967 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1091045002968 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1091045002969 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091045002970 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1091045002971 Aspartase; Region: Aspartase; cd01357 1091045002972 active sites [active] 1091045002973 tetramer interface [polypeptide binding]; other site 1091045002974 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1091045002975 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1091045002976 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1091045002977 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1091045002978 heme binding pocket [chemical binding]; other site 1091045002979 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045002980 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045002981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045002982 Walker A/P-loop; other site 1091045002983 ATP binding site [chemical binding]; other site 1091045002984 Q-loop/lid; other site 1091045002985 ABC transporter signature motif; other site 1091045002986 Walker B; other site 1091045002987 D-loop; other site 1091045002988 H-loop/switch region; other site 1091045002989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045002990 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045002991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045002992 Q-loop/lid; other site 1091045002993 ABC transporter signature motif; other site 1091045002994 Walker B; other site 1091045002995 D-loop; other site 1091045002996 H-loop/switch region; other site 1091045002997 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1091045002998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1091045002999 Walker A motif; other site 1091045003000 ATP binding site [chemical binding]; other site 1091045003001 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1091045003002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1091045003003 Walker A motif; other site 1091045003004 ATP binding site [chemical binding]; other site 1091045003005 Walker B motif; other site 1091045003006 arginine finger; other site 1091045003007 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1091045003008 metal ion-dependent adhesion site (MIDAS); other site 1091045003009 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1091045003010 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1091045003011 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1091045003012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045003013 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1091045003014 FeS/SAM binding site; other site 1091045003015 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1091045003016 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1091045003017 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045003018 Walker A/P-loop; other site 1091045003019 ATP binding site [chemical binding]; other site 1091045003020 Q-loop/lid; other site 1091045003021 ABC transporter signature motif; other site 1091045003022 Walker B; other site 1091045003023 D-loop; other site 1091045003024 H-loop/switch region; other site 1091045003025 FecCD transport family; Region: FecCD; pfam01032 1091045003026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045003027 ABC-ATPase subunit interface; other site 1091045003028 dimer interface [polypeptide binding]; other site 1091045003029 putative PBP binding regions; other site 1091045003030 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1091045003031 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1091045003032 putative ligand binding site [chemical binding]; other site 1091045003033 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1091045003034 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1091045003035 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1091045003036 putative ligand binding site [chemical binding]; other site 1091045003037 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1091045003038 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1091045003039 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1091045003040 dimer interface [polypeptide binding]; other site 1091045003041 substrate binding site [chemical binding]; other site 1091045003042 ATP binding site [chemical binding]; other site 1091045003043 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1091045003044 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1091045003045 thiamine phosphate binding site [chemical binding]; other site 1091045003046 active site 1091045003047 pyrophosphate binding site [ion binding]; other site 1091045003048 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1091045003049 putative active site [active] 1091045003050 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1091045003051 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1091045003052 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091045003053 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091045003054 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1091045003055 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1091045003056 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1091045003057 Ligand Binding Site [chemical binding]; other site 1091045003058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091045003059 dimer interface [polypeptide binding]; other site 1091045003060 phosphorylation site [posttranslational modification] 1091045003061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045003062 ATP binding site [chemical binding]; other site 1091045003063 Mg2+ binding site [ion binding]; other site 1091045003064 G-X-G motif; other site 1091045003065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091045003066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045003067 active site 1091045003068 phosphorylation site [posttranslational modification] 1091045003069 intermolecular recognition site; other site 1091045003070 dimerization interface [polypeptide binding]; other site 1091045003071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091045003072 DNA binding site [nucleotide binding] 1091045003073 EXLDI protein; Region: EXLDI; TIGR04342 1091045003074 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1091045003075 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1091045003076 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1091045003077 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1091045003078 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1091045003079 Transglycosylase; Region: Transgly; pfam00912 1091045003080 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1091045003081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1091045003082 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1091045003083 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1091045003084 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 1091045003085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045003086 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091045003087 O-Antigen ligase; Region: Wzy_C; pfam04932 1091045003088 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1091045003089 putative trimer interface [polypeptide binding]; other site 1091045003090 putative CoA binding site [chemical binding]; other site 1091045003091 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1091045003092 putative trimer interface [polypeptide binding]; other site 1091045003093 putative active site [active] 1091045003094 putative substrate binding site [chemical binding]; other site 1091045003095 putative CoA binding site [chemical binding]; other site 1091045003096 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091045003097 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091045003098 inhibitor-cofactor binding pocket; inhibition site 1091045003099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045003100 catalytic residue [active] 1091045003101 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091045003102 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091045003103 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1091045003104 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1091045003105 O-Antigen ligase; Region: Wzy_C; pfam04932 1091045003106 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1091045003107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045003108 POT family; Region: PTR2; cl17359 1091045003109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091045003110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091045003111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045003112 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1091045003113 classical (c) SDRs; Region: SDR_c; cd05233 1091045003114 NAD(P) binding site [chemical binding]; other site 1091045003115 active site 1091045003116 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1091045003117 dimerization domain swap beta strand [polypeptide binding]; other site 1091045003118 regulatory protein interface [polypeptide binding]; other site 1091045003119 active site 1091045003120 regulatory phosphorylation site [posttranslational modification]; other site 1091045003121 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045003122 active site 1091045003123 phosphorylation site [posttranslational modification] 1091045003124 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1091045003125 active site 1091045003126 P-loop; other site 1091045003127 phosphorylation site [posttranslational modification] 1091045003128 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1091045003129 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1091045003130 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1091045003131 putative substrate binding site [chemical binding]; other site 1091045003132 putative ATP binding site [chemical binding]; other site 1091045003133 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1091045003134 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1091045003135 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1091045003136 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1091045003137 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091045003138 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1091045003139 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1091045003140 O-Antigen ligase; Region: Wzy_C; pfam04932 1091045003141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045003142 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1091045003143 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1091045003144 active site 1091045003145 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1091045003146 homodimer interface [polypeptide binding]; other site 1091045003147 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091045003148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045003149 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1091045003150 active site 1091045003151 catalytic site [active] 1091045003152 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1091045003153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091045003154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045003155 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1091045003156 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1091045003157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045003158 ATP binding site [chemical binding]; other site 1091045003159 putative Mg++ binding site [ion binding]; other site 1091045003160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045003161 nucleotide binding region [chemical binding]; other site 1091045003162 ATP-binding site [chemical binding]; other site 1091045003163 Helicase associated domain (HA2); Region: HA2; pfam04408 1091045003164 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1091045003165 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1091045003166 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1091045003167 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1091045003168 Walker A/P-loop; other site 1091045003169 ATP binding site [chemical binding]; other site 1091045003170 Q-loop/lid; other site 1091045003171 ABC transporter signature motif; other site 1091045003172 Walker B; other site 1091045003173 D-loop; other site 1091045003174 H-loop/switch region; other site 1091045003175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045003176 Walker A/P-loop; other site 1091045003177 ATP binding site [chemical binding]; other site 1091045003178 Q-loop/lid; other site 1091045003179 ABC transporter signature motif; other site 1091045003180 Walker B; other site 1091045003181 D-loop; other site 1091045003182 H-loop/switch region; other site 1091045003183 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1091045003184 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045003185 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1091045003186 Predicted membrane protein [Function unknown]; Region: COG4270 1091045003187 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1091045003188 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1091045003189 putative active site [active] 1091045003190 putative FMN binding site [chemical binding]; other site 1091045003191 putative substrate binding site [chemical binding]; other site 1091045003192 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1091045003193 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1091045003194 dimer interface [polypeptide binding]; other site 1091045003195 PYR/PP interface [polypeptide binding]; other site 1091045003196 TPP binding site [chemical binding]; other site 1091045003197 substrate binding site [chemical binding]; other site 1091045003198 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1091045003199 Domain of unknown function; Region: EKR; smart00890 1091045003200 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1091045003201 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045003202 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1091045003203 TPP-binding site [chemical binding]; other site 1091045003204 dimer interface [polypeptide binding]; other site 1091045003205 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1091045003206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091045003207 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045003208 Domain of unknown function DUF77; Region: DUF77; pfam01910 1091045003209 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091045003210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045003211 DNA-binding site [nucleotide binding]; DNA binding site 1091045003212 FCD domain; Region: FCD; pfam07729 1091045003213 L-lactate permease; Region: Lactate_perm; cl00701 1091045003214 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1091045003215 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1091045003216 Cysteine-rich domain; Region: CCG; pfam02754 1091045003217 Cysteine-rich domain; Region: CCG; pfam02754 1091045003218 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1091045003219 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1091045003220 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1091045003221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045003222 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045003223 Walker A/P-loop; other site 1091045003224 ATP binding site [chemical binding]; other site 1091045003225 Q-loop/lid; other site 1091045003226 ABC transporter signature motif; other site 1091045003227 Walker B; other site 1091045003228 D-loop; other site 1091045003229 H-loop/switch region; other site 1091045003230 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1091045003231 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1091045003232 Walker A/P-loop; other site 1091045003233 ATP binding site [chemical binding]; other site 1091045003234 Q-loop/lid; other site 1091045003235 ABC transporter signature motif; other site 1091045003236 Walker B; other site 1091045003237 D-loop; other site 1091045003238 H-loop/switch region; other site 1091045003239 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1091045003240 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045003241 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1091045003242 Walker A/P-loop; other site 1091045003243 ATP binding site [chemical binding]; other site 1091045003244 Q-loop/lid; other site 1091045003245 ABC transporter signature motif; other site 1091045003246 Walker B; other site 1091045003247 D-loop; other site 1091045003248 H-loop/switch region; other site 1091045003249 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1091045003250 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1091045003251 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1091045003252 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1091045003253 Amino acid permease; Region: AA_permease_2; pfam13520 1091045003254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045003255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045003256 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1091045003257 Walker A/P-loop; other site 1091045003258 ATP binding site [chemical binding]; other site 1091045003259 Q-loop/lid; other site 1091045003260 ABC transporter signature motif; other site 1091045003261 Walker B; other site 1091045003262 D-loop; other site 1091045003263 H-loop/switch region; other site 1091045003264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091045003265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045003266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045003267 Walker A/P-loop; other site 1091045003268 ATP binding site [chemical binding]; other site 1091045003269 Q-loop/lid; other site 1091045003270 ABC transporter signature motif; other site 1091045003271 Walker B; other site 1091045003272 D-loop; other site 1091045003273 H-loop/switch region; other site 1091045003274 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1091045003275 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1091045003276 dimer interface [polypeptide binding]; other site 1091045003277 putative anticodon binding site; other site 1091045003278 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091045003279 motif 1; other site 1091045003280 dimer interface [polypeptide binding]; other site 1091045003281 active site 1091045003282 motif 2; other site 1091045003283 motif 3; other site 1091045003284 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1091045003285 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1091045003286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091045003287 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091045003288 active site 1091045003289 ATP binding site [chemical binding]; other site 1091045003290 substrate binding site [chemical binding]; other site 1091045003291 activation loop (A-loop); other site 1091045003292 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091045003293 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091045003294 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1091045003295 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091045003296 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1091045003297 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091045003298 active site 1091045003299 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091045003300 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091045003301 phosphopeptide binding site; other site 1091045003302 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1091045003303 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091045003304 phosphopeptide binding site; other site 1091045003305 Phosphotransferase enzyme family; Region: APH; pfam01636 1091045003306 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1091045003307 ATP binding site [chemical binding]; other site 1091045003308 RHS Repeat; Region: RHS_repeat; cl11982 1091045003309 RHS Repeat; Region: RHS_repeat; pfam05593 1091045003310 RHS Repeat; Region: RHS_repeat; pfam05593 1091045003311 RHS Repeat; Region: RHS_repeat; cl11982 1091045003312 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1091045003313 potential frameshift: common BLAST hit: gi|50841685|ref|YP_054912.1| RHS-family protein 1091045003314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091045003315 RNA binding surface [nucleotide binding]; other site 1091045003316 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1091045003317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045003318 Walker A motif; other site 1091045003319 ATP binding site [chemical binding]; other site 1091045003320 Walker B motif; other site 1091045003321 arginine finger; other site 1091045003322 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1091045003323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1091045003324 recombination protein RecR; Reviewed; Region: recR; PRK00076 1091045003325 RecR protein; Region: RecR; pfam02132 1091045003326 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1091045003327 putative active site [active] 1091045003328 putative metal-binding site [ion binding]; other site 1091045003329 tetramer interface [polypeptide binding]; other site 1091045003330 Predicted transcriptional regulators [Transcription]; Region: COG1695 1091045003331 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1091045003332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045003333 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045003334 Walker A/P-loop; other site 1091045003335 ATP binding site [chemical binding]; other site 1091045003336 Q-loop/lid; other site 1091045003337 ABC transporter signature motif; other site 1091045003338 Walker B; other site 1091045003339 D-loop; other site 1091045003340 H-loop/switch region; other site 1091045003341 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091045003342 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1091045003343 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1091045003344 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1091045003345 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1091045003346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045003347 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1091045003348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045003349 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045003350 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1091045003351 Walker A/P-loop; other site 1091045003352 ATP binding site [chemical binding]; other site 1091045003353 Q-loop/lid; other site 1091045003354 ABC transporter signature motif; other site 1091045003355 Walker B; other site 1091045003356 D-loop; other site 1091045003357 H-loop/switch region; other site 1091045003358 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1091045003359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045003360 active site 1091045003361 HIGH motif; other site 1091045003362 nucleotide binding site [chemical binding]; other site 1091045003363 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1091045003364 active site 1091045003365 KMSKS motif; other site 1091045003366 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1091045003367 tRNA binding surface [nucleotide binding]; other site 1091045003368 anticodon binding site; other site 1091045003369 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1091045003370 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1091045003371 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1091045003372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091045003373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091045003374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1091045003375 Transcription factor WhiB; Region: Whib; pfam02467 1091045003376 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1091045003377 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1091045003378 homotrimer interaction site [polypeptide binding]; other site 1091045003379 putative active site [active] 1091045003380 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091045003381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091045003382 ligand binding site [chemical binding]; other site 1091045003383 flexible hinge region; other site 1091045003384 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091045003385 putative switch regulator; other site 1091045003386 non-specific DNA interactions [nucleotide binding]; other site 1091045003387 DNA binding site [nucleotide binding] 1091045003388 sequence specific DNA binding site [nucleotide binding]; other site 1091045003389 putative cAMP binding site [chemical binding]; other site 1091045003390 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1091045003391 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091045003392 minor groove reading motif; other site 1091045003393 helix-hairpin-helix signature motif; other site 1091045003394 substrate binding pocket [chemical binding]; other site 1091045003395 active site 1091045003396 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1091045003397 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091045003398 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091045003399 catalytic residues [active] 1091045003400 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1091045003401 putative active site [active] 1091045003402 putative CoA binding site [chemical binding]; other site 1091045003403 nudix motif; other site 1091045003404 metal binding site [ion binding]; metal-binding site 1091045003405 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1091045003406 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1091045003407 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1091045003408 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1091045003409 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1091045003410 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1091045003411 Walker A motif; other site 1091045003412 ATP binding site [chemical binding]; other site 1091045003413 Walker B motif; other site 1091045003414 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091045003415 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1091045003416 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1091045003417 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1091045003418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045003419 ATP binding site [chemical binding]; other site 1091045003420 putative Mg++ binding site [ion binding]; other site 1091045003421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045003422 nucleotide binding region [chemical binding]; other site 1091045003423 ATP-binding site [chemical binding]; other site 1091045003424 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1091045003425 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1091045003426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045003427 S-adenosylmethionine binding site [chemical binding]; other site 1091045003428 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1091045003429 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1091045003430 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1091045003431 active site 1091045003432 interdomain interaction site; other site 1091045003433 putative metal-binding site [ion binding]; other site 1091045003434 nucleotide binding site [chemical binding]; other site 1091045003435 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1091045003436 domain I; other site 1091045003437 DNA binding groove [nucleotide binding] 1091045003438 phosphate binding site [ion binding]; other site 1091045003439 domain II; other site 1091045003440 domain III; other site 1091045003441 nucleotide binding site [chemical binding]; other site 1091045003442 catalytic site [active] 1091045003443 domain IV; other site 1091045003444 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1091045003445 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1091045003446 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1091045003447 thymidylate kinase; Validated; Region: tmk; PRK00698 1091045003448 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1091045003449 TMP-binding site; other site 1091045003450 ATP-binding site [chemical binding]; other site 1091045003451 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1091045003452 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1091045003453 Predicted membrane protein [Function unknown]; Region: COG2259 1091045003454 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1091045003455 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091045003456 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1091045003457 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1091045003458 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045003459 catalytic core [active] 1091045003460 potential frameshift: common BLAST hit: gi|365973159|ref|YP_004954718.1| acetyl xylan esterase (AXE1) 1091045003461 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1091045003462 potential frameshift: common BLAST hit: gi|365973159|ref|YP_004954718.1| acetyl xylan esterase (AXE1) 1091045003463 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1091045003464 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091045003465 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1091045003466 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1091045003467 dimer interface [polypeptide binding]; other site 1091045003468 substrate binding site [chemical binding]; other site 1091045003469 metal binding sites [ion binding]; metal-binding site 1091045003470 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1091045003471 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1091045003472 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1091045003473 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1091045003474 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1091045003475 Ligand Binding Site [chemical binding]; other site 1091045003476 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045003477 active site 1091045003478 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1091045003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045003480 Walker A motif; other site 1091045003481 ATP binding site [chemical binding]; other site 1091045003482 Walker B motif; other site 1091045003483 arginine finger; other site 1091045003484 Peptidase family M41; Region: Peptidase_M41; pfam01434 1091045003485 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1091045003486 homodecamer interface [polypeptide binding]; other site 1091045003487 GTP cyclohydrolase I; Provisional; Region: PLN03044 1091045003488 active site 1091045003489 putative catalytic site residues [active] 1091045003490 zinc binding site [ion binding]; other site 1091045003491 GTP-CH-I/GFRP interaction surface; other site 1091045003492 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091045003493 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091045003494 ligand binding site [chemical binding]; other site 1091045003495 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1091045003496 dihydropteroate synthase; Region: DHPS; TIGR01496 1091045003497 substrate binding pocket [chemical binding]; other site 1091045003498 dimer interface [polypeptide binding]; other site 1091045003499 inhibitor binding site; inhibition site 1091045003500 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1091045003501 homooctamer interface [polypeptide binding]; other site 1091045003502 active site 1091045003503 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1091045003504 catalytic center binding site [active] 1091045003505 ATP binding site [chemical binding]; other site 1091045003506 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1091045003507 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1091045003508 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1091045003509 Lsr2; Region: Lsr2; pfam11774 1091045003510 Clp protease ATP binding subunit; Region: clpC; CHL00095 1091045003511 Clp amino terminal domain; Region: Clp_N; pfam02861 1091045003512 Clp amino terminal domain; Region: Clp_N; pfam02861 1091045003513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045003514 Walker A motif; other site 1091045003515 ATP binding site [chemical binding]; other site 1091045003516 Walker B motif; other site 1091045003517 arginine finger; other site 1091045003518 UvrB/uvrC motif; Region: UVR; pfam02151 1091045003519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045003520 Walker A motif; other site 1091045003521 ATP binding site [chemical binding]; other site 1091045003522 Walker B motif; other site 1091045003523 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1091045003524 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1091045003525 Predicted membrane protein [Function unknown]; Region: COG3817 1091045003526 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1091045003527 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1091045003528 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1091045003529 putative active site [active] 1091045003530 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1091045003531 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1091045003532 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1091045003533 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1091045003534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045003535 putative substrate translocation pore; other site 1091045003536 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1091045003537 TIGR01777 family protein; Region: yfcH 1091045003538 putative NAD(P) binding site [chemical binding]; other site 1091045003539 putative active site [active] 1091045003540 Rhomboid family; Region: Rhomboid; pfam01694 1091045003541 hypothetical protein; Provisional; Region: PRK06547 1091045003542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045003544 active site 1091045003545 phosphorylation site [posttranslational modification] 1091045003546 intermolecular recognition site; other site 1091045003547 dimerization interface [polypeptide binding]; other site 1091045003548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045003549 DNA binding residues [nucleotide binding] 1091045003550 dimerization interface [polypeptide binding]; other site 1091045003551 Histidine kinase; Region: HisKA_3; pfam07730 1091045003552 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1091045003553 ATP binding site [chemical binding]; other site 1091045003554 Mg2+ binding site [ion binding]; other site 1091045003555 G-X-G motif; other site 1091045003556 CAT RNA binding domain; Region: CAT_RBD; smart01061 1091045003557 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1091045003558 PRD domain; Region: PRD; pfam00874 1091045003559 PRD domain; Region: PRD; pfam00874 1091045003560 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1091045003561 HPr interaction site; other site 1091045003562 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1091045003563 active site 1091045003564 phosphorylation site [posttranslational modification] 1091045003565 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1091045003566 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1091045003567 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1091045003568 active site turn [active] 1091045003569 phosphorylation site [posttranslational modification] 1091045003570 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045003571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045003572 D-galactonate transporter; Region: 2A0114; TIGR00893 1091045003573 putative substrate translocation pore; other site 1091045003574 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1091045003575 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1091045003576 potential frameshift: common BLAST hit: gi|291300748|ref|YP_003512026.1| Hrp-dependent type III effector protein 1091045003577 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1091045003578 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1091045003579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1091045003580 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091045003581 endonuclease III; Region: ENDO3c; smart00478 1091045003582 minor groove reading motif; other site 1091045003583 helix-hairpin-helix signature motif; other site 1091045003584 substrate binding pocket [chemical binding]; other site 1091045003585 active site 1091045003586 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1091045003587 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1091045003588 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091045003589 inhibitor-cofactor binding pocket; inhibition site 1091045003590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045003591 catalytic residue [active] 1091045003592 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1091045003593 dimer interface [polypeptide binding]; other site 1091045003594 active site 1091045003595 Schiff base residues; other site 1091045003596 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1091045003597 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1091045003598 active site 1091045003599 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1091045003600 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1091045003601 domain interfaces; other site 1091045003602 active site 1091045003603 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1091045003604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091045003605 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1091045003606 substrate binding site [chemical binding]; other site 1091045003607 active site 1091045003608 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1091045003609 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 1091045003610 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 1091045003611 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1091045003612 ferrochelatase; Reviewed; Region: hemH; PRK00035 1091045003613 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1091045003614 C-terminal domain interface [polypeptide binding]; other site 1091045003615 active site 1091045003616 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1091045003617 active site 1091045003618 N-terminal domain interface [polypeptide binding]; other site 1091045003619 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1091045003620 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1091045003621 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1091045003622 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1091045003623 DNA repair protein RadA; Provisional; Region: PRK11823 1091045003624 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091045003625 Walker A motif; other site 1091045003626 ATP binding site [chemical binding]; other site 1091045003627 Walker B motif; other site 1091045003628 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1091045003629 malate dehydrogenase; Provisional; Region: PRK13529 1091045003630 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1091045003631 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1091045003632 NAD(P) binding pocket [chemical binding]; other site 1091045003633 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1091045003634 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1091045003635 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1091045003636 AP (apurinic/apyrimidinic) site pocket; other site 1091045003637 DNA interaction; other site 1091045003638 Metal-binding active site; metal-binding site 1091045003639 Proline dehydrogenase; Region: Pro_dh; cl03282 1091045003640 potential frameshift: common BLAST hit: gi|295129881|ref|YP_003580544.1| CAAX amino terminal protease family protein 1091045003641 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1091045003642 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1091045003643 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1091045003644 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1091045003645 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1091045003646 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1091045003647 active site 1091045003648 homodimer interface [polypeptide binding]; other site 1091045003649 SAM binding site [chemical binding]; other site 1091045003650 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1091045003651 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1091045003652 active site 1091045003653 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045003654 catalytic core [active] 1091045003655 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091045003656 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091045003657 catalytic residues [active] 1091045003658 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1091045003659 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1091045003660 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1091045003661 ResB-like family; Region: ResB; pfam05140 1091045003662 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1091045003663 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1091045003664 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1091045003665 DNA binding residues [nucleotide binding] 1091045003666 Sporulation and spore germination; Region: Germane; pfam10646 1091045003667 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1091045003668 classical (c) SDRs; Region: SDR_c; cd05233 1091045003669 NAD(P) binding site [chemical binding]; other site 1091045003670 active site 1091045003671 FtsX-like permease family; Region: FtsX; pfam02687 1091045003672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045003673 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1091045003674 Walker A/P-loop; other site 1091045003675 ATP binding site [chemical binding]; other site 1091045003676 Q-loop/lid; other site 1091045003677 ABC transporter signature motif; other site 1091045003678 Walker B; other site 1091045003679 D-loop; other site 1091045003680 H-loop/switch region; other site 1091045003681 potential frameshift: common BLAST hit: gi|295129896|ref|YP_003580559.1| mycothione reductase 1091045003682 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1091045003683 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045003684 intersubunit interface [polypeptide binding]; other site 1091045003685 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1091045003686 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045003687 Walker A/P-loop; other site 1091045003688 ATP binding site [chemical binding]; other site 1091045003689 Q-loop/lid; other site 1091045003690 ABC transporter signature motif; other site 1091045003691 Walker B; other site 1091045003692 D-loop; other site 1091045003693 H-loop/switch region; other site 1091045003694 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1091045003695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045003696 ABC-ATPase subunit interface; other site 1091045003697 dimer interface [polypeptide binding]; other site 1091045003698 putative PBP binding regions; other site 1091045003699 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1091045003700 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1091045003701 FAD binding pocket [chemical binding]; other site 1091045003702 FAD binding motif [chemical binding]; other site 1091045003703 phosphate binding motif [ion binding]; other site 1091045003704 NAD binding pocket [chemical binding]; other site 1091045003705 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1091045003706 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1091045003707 Walker A/P-loop; other site 1091045003708 ATP binding site [chemical binding]; other site 1091045003709 Q-loop/lid; other site 1091045003710 ABC transporter signature motif; other site 1091045003711 Walker B; other site 1091045003712 D-loop; other site 1091045003713 H-loop/switch region; other site 1091045003714 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1091045003715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045003716 dimer interface [polypeptide binding]; other site 1091045003717 conserved gate region; other site 1091045003718 putative PBP binding loops; other site 1091045003719 ABC-ATPase subunit interface; other site 1091045003720 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1091045003721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045003722 dimer interface [polypeptide binding]; other site 1091045003723 conserved gate region; other site 1091045003724 putative PBP binding loops; other site 1091045003725 ABC-ATPase subunit interface; other site 1091045003726 PBP superfamily domain; Region: PBP_like_2; cl17296 1091045003727 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1091045003728 active site 1091045003729 Ap6A binding site [chemical binding]; other site 1091045003730 nudix motif; other site 1091045003731 metal binding site [ion binding]; metal-binding site 1091045003732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045003733 catalytic core [active] 1091045003734 polyphosphate kinase; Provisional; Region: PRK05443 1091045003735 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1091045003736 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1091045003737 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1091045003738 putative domain interface [polypeptide binding]; other site 1091045003739 putative active site [active] 1091045003740 catalytic site [active] 1091045003741 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1091045003742 putative domain interface [polypeptide binding]; other site 1091045003743 putative active site [active] 1091045003744 catalytic site [active] 1091045003745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091045003746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091045003747 DNA binding site [nucleotide binding] 1091045003748 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1091045003749 putative active site [active] 1091045003750 dimerization interface [polypeptide binding]; other site 1091045003751 putative tRNAtyr binding site [nucleotide binding]; other site 1091045003752 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1091045003753 heme-binding site [chemical binding]; other site 1091045003754 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1091045003755 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1091045003756 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1091045003757 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1091045003758 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1091045003759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091045003760 malonic semialdehyde reductase; Provisional; Region: PRK10538 1091045003761 NAD(P) binding site [chemical binding]; other site 1091045003762 active site 1091045003763 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1091045003764 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1091045003765 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1091045003766 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1091045003767 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1091045003768 dimerization domain swap beta strand [polypeptide binding]; other site 1091045003769 regulatory protein interface [polypeptide binding]; other site 1091045003770 active site 1091045003771 regulatory phosphorylation site [posttranslational modification]; other site 1091045003772 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1091045003773 substrate binding site; other site 1091045003774 dimer interface; other site 1091045003775 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1091045003776 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1091045003777 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1091045003778 active site 1091045003779 P-loop; other site 1091045003780 phosphorylation site [posttranslational modification] 1091045003781 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1091045003782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091045003783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045003784 active site 1091045003785 phosphorylation site [posttranslational modification] 1091045003786 intermolecular recognition site; other site 1091045003787 dimerization interface [polypeptide binding]; other site 1091045003788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091045003789 DNA binding site [nucleotide binding] 1091045003790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091045003791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091045003792 dimer interface [polypeptide binding]; other site 1091045003793 phosphorylation site [posttranslational modification] 1091045003794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045003795 ATP binding site [chemical binding]; other site 1091045003796 Mg2+ binding site [ion binding]; other site 1091045003797 G-X-G motif; other site 1091045003798 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1091045003799 PhoU domain; Region: PhoU; pfam01895 1091045003800 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1091045003801 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1091045003802 NodB motif; other site 1091045003803 active site 1091045003804 catalytic site [active] 1091045003805 Zn binding site [ion binding]; other site 1091045003806 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045003807 catalytic core [active] 1091045003808 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1091045003809 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045003810 active site 1091045003811 phosphorylation site [posttranslational modification] 1091045003812 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1091045003813 active site 1091045003814 P-loop; other site 1091045003815 phosphorylation site [posttranslational modification] 1091045003816 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1091045003817 active site 1091045003818 homodimer interface [polypeptide binding]; other site 1091045003819 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091045003820 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1091045003821 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1091045003822 dimer interface [polypeptide binding]; other site 1091045003823 active site 1091045003824 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1091045003825 folate binding site [chemical binding]; other site 1091045003826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091045003827 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1091045003828 substrate binding site [chemical binding]; other site 1091045003829 ATP binding site [chemical binding]; other site 1091045003830 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1091045003831 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1091045003832 active site 1091045003833 intersubunit interface [polypeptide binding]; other site 1091045003834 catalytic residue [active] 1091045003835 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1091045003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091045003837 NAD(P) binding site [chemical binding]; other site 1091045003838 active site 1091045003839 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1091045003840 potential frameshift: common BLAST hit: gi|269793985|ref|YP_003313440.1| succinate dehydrogenase/fumarate reductase flavoprotein subunit 1091045003841 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1091045003842 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1091045003843 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1091045003844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091045003845 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1091045003846 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1091045003847 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1091045003848 substrate binding site [chemical binding]; other site 1091045003849 catalytic residues [active] 1091045003850 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1091045003851 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1091045003852 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091045003853 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1091045003854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045003855 active site 1091045003856 HIGH motif; other site 1091045003857 nucleotide binding site [chemical binding]; other site 1091045003858 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1091045003859 KMSKS motif; other site 1091045003860 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1091045003861 tRNA binding surface [nucleotide binding]; other site 1091045003862 anticodon binding site; other site 1091045003863 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1091045003864 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091045003865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045003866 catalytic residue [active] 1091045003867 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091045003868 Asp23 family; Region: Asp23; pfam03780 1091045003869 Asp23 family; Region: Asp23; pfam03780 1091045003870 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1091045003871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091045003872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091045003873 DNA binding residues [nucleotide binding] 1091045003874 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1091045003875 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1091045003876 Walker A/P-loop; other site 1091045003877 ATP binding site [chemical binding]; other site 1091045003878 Q-loop/lid; other site 1091045003879 ABC transporter signature motif; other site 1091045003880 Walker B; other site 1091045003881 D-loop; other site 1091045003882 H-loop/switch region; other site 1091045003883 TOBE domain; Region: TOBE_2; pfam08402 1091045003884 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1091045003885 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1091045003886 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1091045003887 potential frameshift: common BLAST hit: gi|50841880|ref|YP_055107.1| oxidoreductase 1091045003888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1091045003889 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1091045003890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045003891 dimer interface [polypeptide binding]; other site 1091045003892 conserved gate region; other site 1091045003893 putative PBP binding loops; other site 1091045003894 ABC-ATPase subunit interface; other site 1091045003895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1091045003896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045003897 dimer interface [polypeptide binding]; other site 1091045003898 conserved gate region; other site 1091045003899 ABC-ATPase subunit interface; other site 1091045003900 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1091045003901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091045003902 NAD(P) binding site [chemical binding]; other site 1091045003903 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1091045003904 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1091045003905 substrate-cofactor binding pocket; other site 1091045003906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045003907 catalytic residue [active] 1091045003908 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1091045003909 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1091045003910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1091045003911 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1091045003912 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1091045003913 Walker A/P-loop; other site 1091045003914 ATP binding site [chemical binding]; other site 1091045003915 Q-loop/lid; other site 1091045003916 ABC transporter signature motif; other site 1091045003917 Walker B; other site 1091045003918 D-loop; other site 1091045003919 H-loop/switch region; other site 1091045003920 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091045003921 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091045003922 Protein of unknown function, DUF488; Region: DUF488; cl01246 1091045003923 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1091045003924 putative ADP-ribose binding site [chemical binding]; other site 1091045003925 putative active site [active] 1091045003926 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1091045003927 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1091045003928 NAD(P) binding site [chemical binding]; other site 1091045003929 substrate binding site [chemical binding]; other site 1091045003930 dimer interface [polypeptide binding]; other site 1091045003931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091045003932 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091045003933 Walker A/P-loop; other site 1091045003934 ATP binding site [chemical binding]; other site 1091045003935 Q-loop/lid; other site 1091045003936 ABC transporter signature motif; other site 1091045003937 Walker B; other site 1091045003938 D-loop; other site 1091045003939 H-loop/switch region; other site 1091045003940 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1091045003941 potential frameshift: common BLAST hit: gi|295129969|ref|YP_003580632.1| histidine kinase 1091045003942 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045003944 active site 1091045003945 phosphorylation site [posttranslational modification] 1091045003946 intermolecular recognition site; other site 1091045003947 dimerization interface [polypeptide binding]; other site 1091045003948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045003949 DNA binding residues [nucleotide binding] 1091045003950 dimerization interface [polypeptide binding]; other site 1091045003951 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045003952 catalytic core [active] 1091045003953 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1091045003954 cobyric acid synthase; Provisional; Region: PRK00784 1091045003955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091045003956 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091045003957 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1091045003958 catalytic triad [active] 1091045003959 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1091045003960 active site 1091045003961 SAM binding site [chemical binding]; other site 1091045003962 homodimer interface [polypeptide binding]; other site 1091045003963 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1091045003964 active site 1091045003965 SAM binding site [chemical binding]; other site 1091045003966 homodimer interface [polypeptide binding]; other site 1091045003967 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1091045003968 putative homodimer interface [polypeptide binding]; other site 1091045003969 active site 1091045003970 SAM binding site [chemical binding]; other site 1091045003971 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1091045003972 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1091045003973 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1091045003974 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1091045003975 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1091045003976 active site 1091045003977 SAM binding site [chemical binding]; other site 1091045003978 homodimer interface [polypeptide binding]; other site 1091045003979 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1091045003980 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1091045003981 putative active site [active] 1091045003982 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1091045003983 putative active site [active] 1091045003984 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1091045003985 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1091045003986 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1091045003987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045003988 putative PBP binding regions; other site 1091045003989 ABC-ATPase subunit interface; other site 1091045003990 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1091045003991 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045003992 Walker A/P-loop; other site 1091045003993 ATP binding site [chemical binding]; other site 1091045003994 Q-loop/lid; other site 1091045003995 ABC transporter signature motif; other site 1091045003996 Walker B; other site 1091045003997 D-loop; other site 1091045003998 H-loop/switch region; other site 1091045003999 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045004000 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1091045004001 intersubunit interface [polypeptide binding]; other site 1091045004002 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1091045004003 Nuclease-related domain; Region: NERD; pfam08378 1091045004004 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1091045004005 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1091045004006 cobalt transport protein CbiM; Validated; Region: PRK08319 1091045004007 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1091045004008 cobalt transport protein CbiN; Provisional; Region: PRK02898 1091045004009 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1091045004010 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1091045004011 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1091045004012 Walker A/P-loop; other site 1091045004013 ATP binding site [chemical binding]; other site 1091045004014 Q-loop/lid; other site 1091045004015 ABC transporter signature motif; other site 1091045004016 Walker B; other site 1091045004017 D-loop; other site 1091045004018 H-loop/switch region; other site 1091045004019 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1091045004020 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1091045004021 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1091045004022 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1091045004023 homodimer interface [polypeptide binding]; other site 1091045004024 Walker A motif; other site 1091045004025 ATP binding site [chemical binding]; other site 1091045004026 hydroxycobalamin binding site [chemical binding]; other site 1091045004027 Walker B motif; other site 1091045004028 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091045004029 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1091045004030 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1091045004031 catalytic triad [active] 1091045004032 hypothetical protein; Provisional; Region: PRK07908 1091045004033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091045004034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045004035 homodimer interface [polypeptide binding]; other site 1091045004036 catalytic residue [active] 1091045004037 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1091045004038 homodimer interface [polypeptide binding]; other site 1091045004039 active site 1091045004040 SAM binding site [chemical binding]; other site 1091045004041 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1091045004042 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1091045004043 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1091045004044 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1091045004045 putative dimer interface [polypeptide binding]; other site 1091045004046 active site pocket [active] 1091045004047 putative cataytic base [active] 1091045004048 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1091045004049 homotrimer interface [polypeptide binding]; other site 1091045004050 Walker A motif; other site 1091045004051 GTP binding site [chemical binding]; other site 1091045004052 Walker B motif; other site 1091045004053 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1091045004054 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045004055 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1091045004056 intersubunit interface [polypeptide binding]; other site 1091045004057 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1091045004058 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045004059 active site 1091045004060 phosphorylation site [posttranslational modification] 1091045004061 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1091045004062 active site 1091045004063 P-loop; other site 1091045004064 phosphorylation site [posttranslational modification] 1091045004065 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1091045004066 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1091045004067 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1091045004068 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1091045004069 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1091045004070 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1091045004071 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1091045004072 ring oligomerisation interface [polypeptide binding]; other site 1091045004073 ATP/Mg binding site [chemical binding]; other site 1091045004074 stacking interactions; other site 1091045004075 hinge regions; other site 1091045004076 Transaldolase; Region: Transaldolase; pfam00923 1091045004077 catalytic residue [active] 1091045004078 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1091045004079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045004080 DNA-binding site [nucleotide binding]; DNA binding site 1091045004081 UTRA domain; Region: UTRA; pfam07702 1091045004082 potential frameshift: common BLAST hit: gi|295130013|ref|YP_003580676.1| kinase, PfkB family 1091045004083 KduI/IolB family; Region: KduI; pfam04962 1091045004084 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1091045004085 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1091045004086 PYR/PP interface [polypeptide binding]; other site 1091045004087 dimer interface [polypeptide binding]; other site 1091045004088 TPP binding site [chemical binding]; other site 1091045004089 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1091045004090 molybdopterin cofactor binding site; other site 1091045004091 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1091045004092 TPP-binding site; other site 1091045004093 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1091045004094 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1091045004095 tetrameric interface [polypeptide binding]; other site 1091045004096 NAD binding site [chemical binding]; other site 1091045004097 catalytic residues [active] 1091045004098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1091045004099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1091045004100 DNA binding site [nucleotide binding] 1091045004101 domain linker motif; other site 1091045004102 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1091045004103 dimerization interface [polypeptide binding]; other site 1091045004104 ligand binding site [chemical binding]; other site 1091045004105 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091045004106 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091045004107 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1091045004108 potential frameshift: common BLAST hit: gi|295130021|ref|YP_003580684.1| AP endonuclease, family 2 1091045004109 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1091045004110 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091045004111 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091045004112 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1091045004113 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1091045004114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004115 putative substrate translocation pore; other site 1091045004116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004117 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091045004118 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1091045004119 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1091045004120 DNA interaction; other site 1091045004121 Metal-binding active site; metal-binding site 1091045004122 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091045004123 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091045004124 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1091045004125 CAAX protease self-immunity; Region: Abi; pfam02517 1091045004126 CutC family; Region: CutC; cl01218 1091045004127 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1091045004128 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1091045004129 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1091045004130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045004131 ATP binding site [chemical binding]; other site 1091045004132 putative Mg++ binding site [ion binding]; other site 1091045004133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045004134 nucleotide binding region [chemical binding]; other site 1091045004135 ATP-binding site [chemical binding]; other site 1091045004136 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1091045004137 light-independent protochlorophyllide reductase, iron-sulfur ATP-binding protein; Region: DPOR_bchL; TIGR01281 1091045004138 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1091045004139 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1091045004140 active site 1091045004141 trimer interface [polypeptide binding]; other site 1091045004142 allosteric site; other site 1091045004143 active site lid [active] 1091045004144 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1091045004145 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1091045004146 DNA-binding site [nucleotide binding]; DNA binding site 1091045004147 RNA-binding motif; other site 1091045004148 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1091045004149 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1091045004150 phosphoserine aminotransferase; Provisional; Region: PRK03080 1091045004151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045004152 catalytic residue [active] 1091045004153 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1091045004154 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1091045004155 active site 1091045004156 dimer interface [polypeptide binding]; other site 1091045004157 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1091045004158 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1091045004159 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1091045004160 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091045004161 catalytic residues [active] 1091045004162 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1091045004163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004164 putative substrate translocation pore; other site 1091045004165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004166 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1091045004167 active site 1091045004168 substrate binding site; other site 1091045004169 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1091045004170 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1091045004171 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1091045004172 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1091045004173 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1091045004174 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1091045004175 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1091045004176 dimer interface [polypeptide binding]; other site 1091045004177 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1091045004178 putative MPT binding site; other site 1091045004179 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091045004180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091045004181 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1091045004182 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1091045004183 trimer interface [polypeptide binding]; other site 1091045004184 dimer interface [polypeptide binding]; other site 1091045004185 putative active site [active] 1091045004186 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1091045004187 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1091045004188 dimer interface [polypeptide binding]; other site 1091045004189 putative functional site; other site 1091045004190 putative MPT binding site; other site 1091045004191 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1091045004192 MoaE homodimer interface [polypeptide binding]; other site 1091045004193 MoaD interaction [polypeptide binding]; other site 1091045004194 active site residues [active] 1091045004195 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1091045004196 MoaE interaction surface [polypeptide binding]; other site 1091045004197 MoeB interaction surface [polypeptide binding]; other site 1091045004198 thiocarboxylated glycine; other site 1091045004199 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1091045004200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045004201 FeS/SAM binding site; other site 1091045004202 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1091045004203 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1091045004204 DNA binding residues [nucleotide binding] 1091045004205 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1091045004206 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1091045004207 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1091045004208 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1091045004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045004210 dimer interface [polypeptide binding]; other site 1091045004211 conserved gate region; other site 1091045004212 putative PBP binding loops; other site 1091045004213 ABC-ATPase subunit interface; other site 1091045004214 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1091045004215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045004216 Walker A/P-loop; other site 1091045004217 ATP binding site [chemical binding]; other site 1091045004218 Q-loop/lid; other site 1091045004219 ABC transporter signature motif; other site 1091045004220 Walker B; other site 1091045004221 D-loop; other site 1091045004222 H-loop/switch region; other site 1091045004223 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1091045004224 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1091045004225 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1091045004226 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1091045004227 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1091045004228 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1091045004229 [4Fe-4S] binding site [ion binding]; other site 1091045004230 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091045004231 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091045004232 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091045004233 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1091045004234 molybdopterin cofactor binding site; other site 1091045004235 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1091045004236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004237 putative substrate translocation pore; other site 1091045004238 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1091045004239 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1091045004240 GTP binding site; other site 1091045004241 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1091045004242 MPT binding site; other site 1091045004243 trimer interface [polypeptide binding]; other site 1091045004244 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1091045004245 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1091045004246 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045004247 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1091045004248 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1091045004249 putative [Fe4-S4] binding site [ion binding]; other site 1091045004250 putative molybdopterin cofactor binding site [chemical binding]; other site 1091045004251 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1091045004252 putative molybdopterin cofactor binding site; other site 1091045004253 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1091045004254 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1091045004255 ATP binding site [chemical binding]; other site 1091045004256 substrate interface [chemical binding]; other site 1091045004257 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1091045004258 ThiS interaction site; other site 1091045004259 putative active site [active] 1091045004260 tetramer interface [polypeptide binding]; other site 1091045004261 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1091045004262 thiS-thiF/thiG interaction site; other site 1091045004263 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1091045004264 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1091045004265 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1091045004266 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1091045004267 oligomer interface [polypeptide binding]; other site 1091045004268 metal binding site [ion binding]; metal-binding site 1091045004269 metal binding site [ion binding]; metal-binding site 1091045004270 putative Cl binding site [ion binding]; other site 1091045004271 basic sphincter; other site 1091045004272 hydrophobic gate; other site 1091045004273 periplasmic entrance; other site 1091045004274 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1091045004275 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1091045004276 Predicted methyltransferases [General function prediction only]; Region: COG0313 1091045004277 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1091045004278 putative SAM binding site [chemical binding]; other site 1091045004279 putative homodimer interface [polypeptide binding]; other site 1091045004280 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1091045004281 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1091045004282 active site 1091045004283 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1091045004284 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1091045004285 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1091045004286 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1091045004287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091045004288 MarR family; Region: MarR_2; cl17246 1091045004289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045004290 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1091045004291 DNA-binding interface [nucleotide binding]; DNA binding site 1091045004292 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1091045004293 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1091045004294 Substrate binding site; other site 1091045004295 Mg++ binding site; other site 1091045004296 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1091045004297 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1091045004298 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1091045004299 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045004300 active site 1091045004301 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1091045004302 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1091045004303 5S rRNA interface [nucleotide binding]; other site 1091045004304 CTC domain interface [polypeptide binding]; other site 1091045004305 L16 interface [polypeptide binding]; other site 1091045004306 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1091045004307 putative active site [active] 1091045004308 catalytic residue [active] 1091045004309 Protease prsW family; Region: PrsW-protease; pfam13367 1091045004310 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1091045004311 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1091045004312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045004313 ATP binding site [chemical binding]; other site 1091045004314 putative Mg++ binding site [ion binding]; other site 1091045004315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045004316 nucleotide binding region [chemical binding]; other site 1091045004317 ATP-binding site [chemical binding]; other site 1091045004318 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1091045004319 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1091045004320 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1091045004321 homodimer interface [polypeptide binding]; other site 1091045004322 metal binding site [ion binding]; metal-binding site 1091045004323 enolase; Provisional; Region: eno; PRK00077 1091045004324 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1091045004325 dimer interface [polypeptide binding]; other site 1091045004326 metal binding site [ion binding]; metal-binding site 1091045004327 substrate binding pocket [chemical binding]; other site 1091045004328 Septum formation initiator; Region: DivIC; pfam04977 1091045004329 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1091045004330 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1091045004331 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1091045004332 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1091045004333 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1091045004334 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1091045004335 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1091045004336 nudix motif; other site 1091045004337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091045004338 TPR motif; other site 1091045004339 binding surface 1091045004340 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1091045004341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045004342 active site 1091045004343 motif I; other site 1091045004344 motif II; other site 1091045004345 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1091045004346 BioY family; Region: BioY; pfam02632 1091045004347 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091045004348 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1091045004349 Walker A/P-loop; other site 1091045004350 ATP binding site [chemical binding]; other site 1091045004351 Q-loop/lid; other site 1091045004352 ABC transporter signature motif; other site 1091045004353 Walker B; other site 1091045004354 D-loop; other site 1091045004355 H-loop/switch region; other site 1091045004356 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1091045004357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091045004358 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1091045004359 RNA binding surface [nucleotide binding]; other site 1091045004360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045004361 S-adenosylmethionine binding site [chemical binding]; other site 1091045004362 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1091045004363 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1091045004364 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1091045004365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045004366 Walker A/P-loop; other site 1091045004367 ATP binding site [chemical binding]; other site 1091045004368 Q-loop/lid; other site 1091045004369 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1091045004370 ABC transporter signature motif; other site 1091045004371 Walker B; other site 1091045004372 D-loop; other site 1091045004373 H-loop/switch region; other site 1091045004374 CTP synthetase; Validated; Region: pyrG; PRK05380 1091045004375 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1091045004376 Catalytic site [active] 1091045004377 active site 1091045004378 UTP binding site [chemical binding]; other site 1091045004379 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1091045004380 active site 1091045004381 putative oxyanion hole; other site 1091045004382 catalytic triad [active] 1091045004383 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1091045004384 dimer interface [polypeptide binding]; other site 1091045004385 ADP-ribose binding site [chemical binding]; other site 1091045004386 active site 1091045004387 nudix motif; other site 1091045004388 metal binding site [ion binding]; metal-binding site 1091045004389 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1091045004390 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1091045004391 active site 1091045004392 Int/Topo IB signature motif; other site 1091045004393 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091045004394 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091045004395 P-loop; other site 1091045004396 Magnesium ion binding site [ion binding]; other site 1091045004397 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1091045004398 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091045004399 Magnesium ion binding site [ion binding]; other site 1091045004400 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1091045004401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091045004402 RNA binding surface [nucleotide binding]; other site 1091045004403 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1091045004404 active site 1091045004405 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091045004406 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091045004407 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045004408 active site 1091045004409 HIGH motif; other site 1091045004410 nucleotide binding site [chemical binding]; other site 1091045004411 active site 1091045004412 KMSKS motif; other site 1091045004413 Predicted transcriptional regulator [Transcription]; Region: COG2378 1091045004414 WYL domain; Region: WYL; pfam13280 1091045004415 Predicted transcriptional regulator [Transcription]; Region: COG2378 1091045004416 WYL domain; Region: WYL; pfam13280 1091045004417 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1091045004418 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1091045004419 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1091045004420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045004421 ATP binding site [chemical binding]; other site 1091045004422 putative Mg++ binding site [ion binding]; other site 1091045004423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045004424 nucleotide binding region [chemical binding]; other site 1091045004425 ATP-binding site [chemical binding]; other site 1091045004426 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1091045004427 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1091045004428 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1091045004429 substrate binding site [chemical binding]; other site 1091045004430 glutamase interaction surface [polypeptide binding]; other site 1091045004431 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1091045004432 HIT family signature motif; other site 1091045004433 catalytic residue [active] 1091045004434 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1091045004435 TPP-binding site [chemical binding]; other site 1091045004436 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1091045004437 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1091045004438 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1091045004439 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1091045004440 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1091045004441 tartrate dehydrogenase; Region: TTC; TIGR02089 1091045004442 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1091045004443 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1091045004444 homodimer interface [polypeptide binding]; other site 1091045004445 substrate-cofactor binding pocket; other site 1091045004446 catalytic residue [active] 1091045004447 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1091045004448 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1091045004449 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1091045004450 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1091045004451 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1091045004452 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1091045004453 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1091045004454 CAAX protease self-immunity; Region: Abi; pfam02517 1091045004455 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1091045004456 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1091045004457 Bacterial transcriptional regulator; Region: IclR; pfam01614 1091045004458 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1091045004459 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1091045004460 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1091045004461 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091045004462 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091045004463 putative acyl-acceptor binding pocket; other site 1091045004464 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1091045004465 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1091045004466 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1091045004467 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1091045004468 thiamine monophosphate kinase; Provisional; Region: PRK05731 1091045004469 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1091045004470 ATP binding site [chemical binding]; other site 1091045004471 dimerization interface [polypeptide binding]; other site 1091045004472 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1091045004473 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1091045004474 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091045004475 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1091045004476 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1091045004477 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1091045004478 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1091045004479 RF-1 domain; Region: RF-1; pfam00472 1091045004480 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1091045004481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045004482 Walker A/P-loop; other site 1091045004483 ATP binding site [chemical binding]; other site 1091045004484 Q-loop/lid; other site 1091045004485 ABC transporter signature motif; other site 1091045004486 Walker B; other site 1091045004487 D-loop; other site 1091045004488 H-loop/switch region; other site 1091045004489 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1091045004490 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1091045004491 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1091045004492 SmpB-tmRNA interface; other site 1091045004493 potential frameshift: common BLAST hit: gi|295130886|ref|YP_003581549.1| N-acetyl-gamma-glutamyl-phosphate reductase 1091045004494 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1091045004495 heterotetramer interface [polypeptide binding]; other site 1091045004496 active site pocket [active] 1091045004497 cleavage site 1091045004498 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1091045004499 feedback inhibition sensing region; other site 1091045004500 homohexameric interface [polypeptide binding]; other site 1091045004501 nucleotide binding site [chemical binding]; other site 1091045004502 N-acetyl-L-glutamate binding site [chemical binding]; other site 1091045004503 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1091045004504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091045004505 inhibitor-cofactor binding pocket; inhibition site 1091045004506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045004507 catalytic residue [active] 1091045004508 argininosuccinate lyase; Provisional; Region: PRK00855 1091045004509 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1091045004510 active sites [active] 1091045004511 tetramer interface [polypeptide binding]; other site 1091045004512 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1091045004513 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1091045004514 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1091045004515 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1091045004516 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091045004517 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091045004518 Walker A/P-loop; other site 1091045004519 ATP binding site [chemical binding]; other site 1091045004520 Q-loop/lid; other site 1091045004521 ABC transporter signature motif; other site 1091045004522 Walker B; other site 1091045004523 D-loop; other site 1091045004524 H-loop/switch region; other site 1091045004525 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1091045004526 Predicted transcriptional regulators [Transcription]; Region: COG1695 1091045004527 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1091045004528 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1091045004529 HNH endonuclease; Region: HNH; pfam01844 1091045004530 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1091045004531 ribbon-helix-helix domain containing protein; Region: PHA00617 1091045004532 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1091045004533 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1091045004534 hypothetical protein; Validated; Region: PRK00228 1091045004535 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091045004536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045004537 active site 1091045004538 phosphorylation site [posttranslational modification] 1091045004539 intermolecular recognition site; other site 1091045004540 dimerization interface [polypeptide binding]; other site 1091045004541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091045004542 DNA binding site [nucleotide binding] 1091045004543 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1091045004544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091045004545 dimerization interface [polypeptide binding]; other site 1091045004546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091045004547 dimer interface [polypeptide binding]; other site 1091045004548 phosphorylation site [posttranslational modification] 1091045004549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045004550 ATP binding site [chemical binding]; other site 1091045004551 Mg2+ binding site [ion binding]; other site 1091045004552 G-X-G motif; other site 1091045004553 Sporulation and spore germination; Region: Germane; pfam10646 1091045004554 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 1091045004555 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1091045004556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045004557 active site 1091045004558 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1091045004559 30S subunit binding site; other site 1091045004560 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1091045004561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091045004562 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1091045004563 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1091045004564 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1091045004565 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1091045004566 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1091045004567 active site 1091045004568 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1091045004569 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1091045004570 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1091045004571 active site 1091045004572 HIGH motif; other site 1091045004573 dimer interface [polypeptide binding]; other site 1091045004574 KMSKS motif; other site 1091045004575 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091045004576 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091045004577 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1091045004578 ATP binding site [chemical binding]; other site 1091045004579 Mg++ binding site [ion binding]; other site 1091045004580 motif III; other site 1091045004581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045004582 nucleotide binding region [chemical binding]; other site 1091045004583 ATP-binding site [chemical binding]; other site 1091045004584 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1091045004585 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091045004586 active site 1091045004587 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1091045004588 Part of AAA domain; Region: AAA_19; pfam13245 1091045004589 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1091045004590 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1091045004591 Part of AAA domain; Region: AAA_19; pfam13245 1091045004592 Family description; Region: UvrD_C_2; pfam13538 1091045004593 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1091045004594 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1091045004595 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1091045004596 putative NADH binding site [chemical binding]; other site 1091045004597 putative active site [active] 1091045004598 nudix motif; other site 1091045004599 putative metal binding site [ion binding]; other site 1091045004600 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1091045004601 AAA domain; Region: AAA_30; pfam13604 1091045004602 Family description; Region: UvrD_C_2; pfam13538 1091045004603 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1091045004604 Part of AAA domain; Region: AAA_19; pfam13245 1091045004605 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1091045004606 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1091045004607 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1091045004608 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1091045004609 Part of AAA domain; Region: AAA_19; pfam13245 1091045004610 Family description; Region: UvrD_C_2; pfam13538 1091045004611 HRDC domain; Region: HRDC; pfam00570 1091045004612 Protein of unknown function DUF45; Region: DUF45; pfam01863 1091045004613 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1091045004614 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1091045004615 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091045004616 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1091045004617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091045004618 Ligand Binding Site [chemical binding]; other site 1091045004619 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1091045004620 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091045004621 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1091045004622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1091045004623 ParB-like nuclease domain; Region: ParBc; cl02129 1091045004624 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1091045004625 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1091045004626 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091045004627 dimer interface [polypeptide binding]; other site 1091045004628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045004629 catalytic residue [active] 1091045004630 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1091045004631 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1091045004632 Condensation domain; Region: Condensation; pfam00668 1091045004633 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1091045004634 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1091045004635 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1091045004636 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091045004637 AMP binding site [chemical binding]; other site 1091045004638 active site 1091045004639 acyl-activating enzyme (AAE) consensus motif; other site 1091045004640 CoA binding site [chemical binding]; other site 1091045004641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091045004642 Thioesterase domain; Region: Thioesterase; pfam00975 1091045004643 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1091045004644 Domain of unknown function (DUF929); Region: DUF929; pfam06053 1091045004645 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091045004646 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091045004647 P-loop; other site 1091045004648 Magnesium ion binding site [ion binding]; other site 1091045004649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091045004650 sequence-specific DNA binding site [nucleotide binding]; other site 1091045004651 salt bridge; other site 1091045004652 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1091045004653 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1091045004654 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1091045004655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045004656 dimer interface [polypeptide binding]; other site 1091045004657 conserved gate region; other site 1091045004658 putative PBP binding loops; other site 1091045004659 ABC-ATPase subunit interface; other site 1091045004660 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1091045004661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045004662 dimer interface [polypeptide binding]; other site 1091045004663 conserved gate region; other site 1091045004664 putative PBP binding loops; other site 1091045004665 ABC-ATPase subunit interface; other site 1091045004666 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1091045004667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091045004668 Walker A/P-loop; other site 1091045004669 ATP binding site [chemical binding]; other site 1091045004670 Q-loop/lid; other site 1091045004671 ABC transporter signature motif; other site 1091045004672 Walker B; other site 1091045004673 D-loop; other site 1091045004674 H-loop/switch region; other site 1091045004675 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1091045004676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091045004677 Walker A/P-loop; other site 1091045004678 ATP binding site [chemical binding]; other site 1091045004679 Q-loop/lid; other site 1091045004680 ABC transporter signature motif; other site 1091045004681 Walker B; other site 1091045004682 D-loop; other site 1091045004683 H-loop/switch region; other site 1091045004684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1091045004685 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1091045004686 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1091045004687 ligand binding site [chemical binding]; other site 1091045004688 NAD binding site [chemical binding]; other site 1091045004689 tetramer interface [polypeptide binding]; other site 1091045004690 catalytic site [active] 1091045004691 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1091045004692 L-serine binding site [chemical binding]; other site 1091045004693 ACT domain interface; other site 1091045004694 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091045004695 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1091045004696 active site 1091045004697 Predicted GTPases [General function prediction only]; Region: COG1162 1091045004698 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1091045004699 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1091045004700 GTP/Mg2+ binding site [chemical binding]; other site 1091045004701 G4 box; other site 1091045004702 G5 box; other site 1091045004703 G1 box; other site 1091045004704 Switch I region; other site 1091045004705 G2 box; other site 1091045004706 G3 box; other site 1091045004707 Switch II region; other site 1091045004708 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1091045004709 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1091045004710 hinge; other site 1091045004711 active site 1091045004712 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1091045004713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091045004714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091045004715 DNA binding residues [nucleotide binding] 1091045004716 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1091045004717 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1091045004718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1091045004719 Histidine kinase; Region: HisKA_2; pfam07568 1091045004720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045004721 ATP binding site [chemical binding]; other site 1091045004722 Mg2+ binding site [ion binding]; other site 1091045004723 G-X-G motif; other site 1091045004724 Transcription factor WhiB; Region: Whib; pfam02467 1091045004725 glutathione S-transferase DHAR1; Region: PLN02378 1091045004726 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1091045004727 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091045004728 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1091045004729 TPP-binding site [chemical binding]; other site 1091045004730 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1091045004731 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1091045004732 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1091045004733 active site 1091045004734 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091045004735 substrate binding site [chemical binding]; other site 1091045004736 catalytic residues [active] 1091045004737 dimer interface [polypeptide binding]; other site 1091045004738 homoserine dehydrogenase; Provisional; Region: PRK06349 1091045004739 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1091045004740 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1091045004741 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1091045004742 threonine synthase; Reviewed; Region: PRK06721 1091045004743 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1091045004744 homodimer interface [polypeptide binding]; other site 1091045004745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045004746 catalytic residue [active] 1091045004747 homoserine kinase; Provisional; Region: PRK01212 1091045004748 transcription termination factor Rho; Provisional; Region: PRK12678 1091045004749 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1091045004750 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1091045004751 RNA binding site [nucleotide binding]; other site 1091045004752 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091045004753 Walker A motif; other site 1091045004754 ATP binding site [chemical binding]; other site 1091045004755 Walker B motif; other site 1091045004756 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1091045004757 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1091045004758 PCRF domain; Region: PCRF; pfam03462 1091045004759 RF-1 domain; Region: RF-1; pfam00472 1091045004760 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1091045004761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045004762 S-adenosylmethionine binding site [chemical binding]; other site 1091045004763 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1091045004764 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1091045004765 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1091045004766 putative catalytic motif [active] 1091045004767 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1091045004768 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1091045004769 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1091045004770 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1091045004771 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1091045004772 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1091045004773 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1091045004774 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1091045004775 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1091045004776 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091045004777 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1091045004778 beta subunit interaction interface [polypeptide binding]; other site 1091045004779 Walker A motif; other site 1091045004780 ATP binding site [chemical binding]; other site 1091045004781 Walker B motif; other site 1091045004782 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091045004783 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1091045004784 core domain interface [polypeptide binding]; other site 1091045004785 delta subunit interface [polypeptide binding]; other site 1091045004786 epsilon subunit interface [polypeptide binding]; other site 1091045004787 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1091045004788 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091045004789 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1091045004790 alpha subunit interaction interface [polypeptide binding]; other site 1091045004791 Walker A motif; other site 1091045004792 ATP binding site [chemical binding]; other site 1091045004793 Walker B motif; other site 1091045004794 inhibitor binding site; inhibition site 1091045004795 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091045004796 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1091045004797 gamma subunit interface [polypeptide binding]; other site 1091045004798 epsilon subunit interface [polypeptide binding]; other site 1091045004799 LBP interface [polypeptide binding]; other site 1091045004800 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1091045004801 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1091045004802 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1091045004803 Fe-S cluster binding site [ion binding]; other site 1091045004804 DNA binding site [nucleotide binding] 1091045004805 active site 1091045004806 MarR family; Region: MarR; pfam01047 1091045004807 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1091045004808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004809 putative substrate translocation pore; other site 1091045004810 hypothetical protein; Provisional; Region: PRK09256 1091045004811 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1091045004812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091045004813 dimerization interface [polypeptide binding]; other site 1091045004814 putative DNA binding site [nucleotide binding]; other site 1091045004815 putative Zn2+ binding site [ion binding]; other site 1091045004816 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1091045004817 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1091045004818 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1091045004819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091045004820 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091045004821 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1091045004822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091045004823 non-specific DNA binding site [nucleotide binding]; other site 1091045004824 salt bridge; other site 1091045004825 sequence-specific DNA binding site [nucleotide binding]; other site 1091045004826 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1091045004827 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1091045004828 putative active site [active] 1091045004829 potential frameshift: common BLAST hit: gi|365974092|ref|YP_004955651.1| pyridoxamine kinase 1091045004830 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1091045004831 ATP binding site [chemical binding]; other site 1091045004832 substrate binding site [chemical binding]; other site 1091045004833 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1091045004834 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1091045004835 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1091045004836 putative active site [active] 1091045004837 putative metal binding site [ion binding]; other site 1091045004838 catalytic site [active] 1091045004839 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1091045004840 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1091045004841 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1091045004842 Ligand binding site; other site 1091045004843 Putative Catalytic site; other site 1091045004844 DXD motif; other site 1091045004845 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1091045004846 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1091045004847 putative active site [active] 1091045004848 catalytic triad [active] 1091045004849 putative dimer interface [polypeptide binding]; other site 1091045004850 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1091045004851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091045004852 putative DNA binding site [nucleotide binding]; other site 1091045004853 putative Zn2+ binding site [ion binding]; other site 1091045004854 AsnC family; Region: AsnC_trans_reg; pfam01037 1091045004855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091045004856 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1091045004857 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1091045004858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045004859 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1091045004860 active site 1091045004861 motif I; other site 1091045004862 motif II; other site 1091045004863 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091045004864 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1091045004865 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1091045004866 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1091045004867 intersubunit interface [polypeptide binding]; other site 1091045004868 active site 1091045004869 catalytic residue [active] 1091045004870 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1091045004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045004872 putative substrate translocation pore; other site 1091045004873 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091045004874 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1091045004875 substrate binding site [chemical binding]; other site 1091045004876 dimer interface [polypeptide binding]; other site 1091045004877 ATP binding site [chemical binding]; other site 1091045004878 GTP-binding protein Der; Reviewed; Region: PRK03003 1091045004879 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1091045004880 G1 box; other site 1091045004881 GTP/Mg2+ binding site [chemical binding]; other site 1091045004882 Switch I region; other site 1091045004883 G2 box; other site 1091045004884 Switch II region; other site 1091045004885 G3 box; other site 1091045004886 G4 box; other site 1091045004887 G5 box; other site 1091045004888 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1091045004889 G1 box; other site 1091045004890 GTP/Mg2+ binding site [chemical binding]; other site 1091045004891 Switch I region; other site 1091045004892 G2 box; other site 1091045004893 G3 box; other site 1091045004894 Switch II region; other site 1091045004895 G4 box; other site 1091045004896 G5 box; other site 1091045004897 cytidylate kinase; Provisional; Region: cmk; PRK00023 1091045004898 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1091045004899 CMP-binding site; other site 1091045004900 prephenate dehydrogenase; Validated; Region: PRK06545 1091045004901 prephenate dehydrogenase; Validated; Region: PRK08507 1091045004902 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1091045004903 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1091045004904 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1091045004905 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1091045004906 active site 1091045004907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045004908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045004909 ABC transporter; Region: ABC_tran; pfam00005 1091045004910 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1091045004911 Predicted membrane protein [Function unknown]; Region: COG1511 1091045004912 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1091045004913 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1091045004914 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1091045004915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045004916 motif II; other site 1091045004917 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1091045004918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045004919 S-adenosylmethionine binding site [chemical binding]; other site 1091045004920 PAC2 family; Region: PAC2; pfam09754 1091045004921 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1091045004922 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1091045004923 substrate binding site [chemical binding]; other site 1091045004924 hexamer interface [polypeptide binding]; other site 1091045004925 metal binding site [ion binding]; metal-binding site 1091045004926 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1091045004927 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1091045004928 putative RNA binding site [nucleotide binding]; other site 1091045004929 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1091045004930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091045004931 S-adenosylmethionine binding site [chemical binding]; other site 1091045004932 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1091045004933 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1091045004934 putative active site [active] 1091045004935 substrate binding site [chemical binding]; other site 1091045004936 putative cosubstrate binding site; other site 1091045004937 catalytic site [active] 1091045004938 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1091045004939 substrate binding site [chemical binding]; other site 1091045004940 primosome assembly protein PriA; Provisional; Region: PRK14873 1091045004941 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1091045004942 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1091045004943 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1091045004944 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1091045004945 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1091045004946 Flavoprotein; Region: Flavoprotein; pfam02441 1091045004947 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1091045004948 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1091045004949 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1091045004950 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1091045004951 catalytic site [active] 1091045004952 G-X2-G-X-G-K; other site 1091045004953 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1091045004954 transcription antitermination factor NusB; Region: nusB; TIGR01951 1091045004955 putative RNA binding site [nucleotide binding]; other site 1091045004956 elongation factor P; Validated; Region: PRK00529 1091045004957 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1091045004958 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1091045004959 RNA binding site [nucleotide binding]; other site 1091045004960 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1091045004961 RNA binding site [nucleotide binding]; other site 1091045004962 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1091045004963 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1091045004964 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1091045004965 putative active site [active] 1091045004966 putative metal binding site [ion binding]; other site 1091045004967 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1091045004968 dimer interface [polypeptide binding]; other site 1091045004969 active site 1091045004970 metal binding site [ion binding]; metal-binding site 1091045004971 shikimate kinase; Reviewed; Region: aroK; PRK00131 1091045004972 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1091045004973 ADP binding site [chemical binding]; other site 1091045004974 magnesium binding site [ion binding]; other site 1091045004975 putative shikimate binding site; other site 1091045004976 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1091045004977 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1091045004978 Tetramer interface [polypeptide binding]; other site 1091045004979 active site 1091045004980 FMN-binding site [chemical binding]; other site 1091045004981 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1091045004982 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1091045004983 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1091045004984 shikimate binding site; other site 1091045004985 NAD(P) binding site [chemical binding]; other site 1091045004986 YceG-like family; Region: YceG; pfam02618 1091045004987 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1091045004988 dimerization interface [polypeptide binding]; other site 1091045004989 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1091045004990 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1091045004991 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1091045004992 motif 1; other site 1091045004993 active site 1091045004994 motif 2; other site 1091045004995 motif 3; other site 1091045004996 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1091045004997 recombination factor protein RarA; Reviewed; Region: PRK13342 1091045004998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045004999 Walker A motif; other site 1091045005000 ATP binding site [chemical binding]; other site 1091045005001 Walker B motif; other site 1091045005002 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1091045005003 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1091045005004 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1091045005005 dimer interface [polypeptide binding]; other site 1091045005006 anticodon binding site; other site 1091045005007 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1091045005008 homodimer interface [polypeptide binding]; other site 1091045005009 motif 1; other site 1091045005010 active site 1091045005011 motif 2; other site 1091045005012 GAD domain; Region: GAD; pfam02938 1091045005013 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091045005014 active site 1091045005015 motif 3; other site 1091045005016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045005017 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1091045005018 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1091045005019 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1091045005020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1091045005021 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1091045005022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1091045005023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1091045005024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091045005025 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1091045005026 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1091045005027 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1091045005028 dimer interface [polypeptide binding]; other site 1091045005029 motif 1; other site 1091045005030 active site 1091045005031 motif 2; other site 1091045005032 motif 3; other site 1091045005033 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1091045005034 anticodon binding site; other site 1091045005035 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1091045005036 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1091045005037 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1091045005038 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1091045005039 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1091045005040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091045005041 Zn2+ binding site [ion binding]; other site 1091045005042 Mg2+ binding site [ion binding]; other site 1091045005043 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1091045005044 synthetase active site [active] 1091045005045 NTP binding site [chemical binding]; other site 1091045005046 metal binding site [ion binding]; metal-binding site 1091045005047 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1091045005048 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1091045005049 Ion channel; Region: Ion_trans_2; pfam07885 1091045005050 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091045005051 TrkA-N domain; Region: TrkA_N; pfam02254 1091045005052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045005053 active site 1091045005054 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1091045005055 Protein export membrane protein; Region: SecD_SecF; pfam02355 1091045005056 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1091045005057 Protein export membrane protein; Region: SecD_SecF; cl14618 1091045005058 Preprotein translocase subunit; Region: YajC; pfam02699 1091045005059 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1091045005060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045005061 Walker A motif; other site 1091045005062 ATP binding site [chemical binding]; other site 1091045005063 Walker B motif; other site 1091045005064 arginine finger; other site 1091045005065 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1091045005066 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1091045005067 RuvA N terminal domain; Region: RuvA_N; pfam01330 1091045005068 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1091045005069 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1091045005070 active site 1091045005071 putative DNA-binding cleft [nucleotide binding]; other site 1091045005072 dimer interface [polypeptide binding]; other site 1091045005073 hypothetical protein; Validated; Region: PRK00110 1091045005074 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1091045005075 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1091045005076 catalytic residues [active] 1091045005077 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1091045005078 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1091045005079 putative active site [active] 1091045005080 oxyanion strand; other site 1091045005081 catalytic triad [active] 1091045005082 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1091045005083 putative active site pocket [active] 1091045005084 4-fold oligomerization interface [polypeptide binding]; other site 1091045005085 metal binding residues [ion binding]; metal-binding site 1091045005086 3-fold/trimer interface [polypeptide binding]; other site 1091045005087 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1091045005088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091045005089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045005090 homodimer interface [polypeptide binding]; other site 1091045005091 catalytic residue [active] 1091045005092 histidinol dehydrogenase; Region: hisD; TIGR00069 1091045005093 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1091045005094 NAD binding site [chemical binding]; other site 1091045005095 dimerization interface [polypeptide binding]; other site 1091045005096 product binding site; other site 1091045005097 substrate binding site [chemical binding]; other site 1091045005098 zinc binding site [ion binding]; other site 1091045005099 catalytic residues [active] 1091045005100 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1091045005101 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1091045005102 active site 1091045005103 PHP Thumb interface [polypeptide binding]; other site 1091045005104 metal binding site [ion binding]; metal-binding site 1091045005105 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1091045005106 generic binding surface II; other site 1091045005107 generic binding surface I; other site 1091045005108 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1091045005109 methionine cluster; other site 1091045005110 active site 1091045005111 phosphorylation site [posttranslational modification] 1091045005112 metal binding site [ion binding]; metal-binding site 1091045005113 potential frameshift: common BLAST hit: gi|50842627|ref|YP_055854.1| PTS system, cellobiose-specific IIC component 1091045005114 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1091045005115 active site 1091045005116 P-loop; other site 1091045005117 phosphorylation site [posttranslational modification] 1091045005118 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1091045005119 beta-galactosidase; Region: BGL; TIGR03356 1091045005120 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1091045005121 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1091045005122 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1091045005123 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1091045005124 active site turn [active] 1091045005125 phosphorylation site [posttranslational modification] 1091045005126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1091045005127 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1091045005128 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1091045005129 putative active site [active] 1091045005130 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1091045005131 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1091045005132 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1091045005133 putative active site [active] 1091045005134 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1091045005135 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091045005136 Beta-lactamase; Region: Beta-lactamase; cl17358 1091045005137 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1091045005138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091045005139 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1091045005140 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1091045005141 active site 1091045005142 dimer interface [polypeptide binding]; other site 1091045005143 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1091045005144 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1091045005145 active site 1091045005146 FMN binding site [chemical binding]; other site 1091045005147 substrate binding site [chemical binding]; other site 1091045005148 3Fe-4S cluster binding site [ion binding]; other site 1091045005149 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1091045005150 domain interface; other site 1091045005151 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1091045005152 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1091045005153 substrate binding site [chemical binding]; other site 1091045005154 active site 1091045005155 catalytic residues [active] 1091045005156 heterodimer interface [polypeptide binding]; other site 1091045005157 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1091045005158 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1091045005159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045005160 catalytic residue [active] 1091045005161 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1091045005162 active site 1091045005163 ribulose/triose binding site [chemical binding]; other site 1091045005164 phosphate binding site [ion binding]; other site 1091045005165 substrate (anthranilate) binding pocket [chemical binding]; other site 1091045005166 product (indole) binding pocket [chemical binding]; other site 1091045005167 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1091045005168 anthranilate synthase component I; Provisional; Region: PRK13571 1091045005169 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1091045005170 TIGR03085 family protein; Region: TIGR03085 1091045005171 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1091045005172 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1091045005173 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1091045005174 GatB domain; Region: GatB_Yqey; smart00845 1091045005175 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1091045005176 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1091045005177 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1091045005178 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1091045005179 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1091045005180 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1091045005181 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1091045005182 Ligand Binding Site [chemical binding]; other site 1091045005183 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1091045005184 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1091045005185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045005186 catalytic residue [active] 1091045005187 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1091045005188 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1091045005189 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1091045005190 active site 1091045005191 catalytic site [active] 1091045005192 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1091045005193 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1091045005194 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1091045005195 active site 1091045005196 homodimer interface [polypeptide binding]; other site 1091045005197 catalytic site [active] 1091045005198 acceptor binding site [chemical binding]; other site 1091045005199 trehalose synthase; Region: treS_nterm; TIGR02456 1091045005200 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1091045005201 active site 1091045005202 catalytic site [active] 1091045005203 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1091045005204 glycogen branching enzyme; Provisional; Region: PRK12313 1091045005205 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1091045005206 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1091045005207 active site 1091045005208 catalytic site [active] 1091045005209 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1091045005210 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091045005211 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1091045005212 nudix motif; other site 1091045005213 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1091045005214 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1091045005215 active site turn [active] 1091045005216 phosphorylation site [posttranslational modification] 1091045005217 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1091045005218 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1091045005219 HPr interaction site; other site 1091045005220 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1091045005221 active site 1091045005222 phosphorylation site [posttranslational modification] 1091045005223 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1091045005224 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1091045005225 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1091045005226 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1091045005227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091045005228 active site 1091045005229 motif I; other site 1091045005230 motif II; other site 1091045005231 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1091045005232 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1091045005233 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1091045005234 phosphoglucomutase; Validated; Region: PRK07564 1091045005235 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1091045005236 active site 1091045005237 substrate binding site [chemical binding]; other site 1091045005238 metal binding site [ion binding]; metal-binding site 1091045005239 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1091045005240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091045005241 dimer interface [polypeptide binding]; other site 1091045005242 substrate binding site [chemical binding]; other site 1091045005243 metal binding site [ion binding]; metal-binding site 1091045005244 DivIVA protein; Region: DivIVA; pfam05103 1091045005245 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1091045005246 hypothetical protein; Provisional; Region: PRK03298 1091045005247 acyl-CoA esterase; Provisional; Region: PRK10673 1091045005248 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1091045005249 active site 1091045005250 PAC2 family; Region: PAC2; pfam09754 1091045005251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091045005252 Predicted membrane protein [Function unknown]; Region: COG1289 1091045005253 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1091045005254 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1091045005255 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1091045005256 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1091045005257 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1091045005258 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1091045005259 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1091045005260 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1091045005261 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1091045005262 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1091045005263 active site 1091045005264 ADP/pyrophosphate binding site [chemical binding]; other site 1091045005265 fructose-1,6-bisphosphate binding site; other site 1091045005266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045005267 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1091045005268 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1091045005269 DNA binding residues [nucleotide binding] 1091045005270 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091045005271 putative dimer interface [polypeptide binding]; other site 1091045005272 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1091045005273 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1091045005274 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091045005275 DNA binding residues [nucleotide binding] 1091045005276 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1091045005277 Double zinc ribbon; Region: DZR; pfam12773 1091045005278 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091045005279 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091045005280 phosphopeptide binding site; other site 1091045005281 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1091045005282 lipoyl attachment site [posttranslational modification]; other site 1091045005283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1091045005284 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1091045005285 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1091045005286 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1091045005287 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1091045005288 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1091045005289 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1091045005290 nucleotide binding site/active site [active] 1091045005291 HIT family signature motif; other site 1091045005292 catalytic residue [active] 1091045005293 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1091045005294 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1091045005295 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1091045005296 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1091045005297 active site 1091045005298 dimer interface [polypeptide binding]; other site 1091045005299 motif 1; other site 1091045005300 motif 2; other site 1091045005301 motif 3; other site 1091045005302 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1091045005303 anticodon binding site; other site 1091045005304 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045005305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045005306 active site 1091045005307 phosphorylation site [posttranslational modification] 1091045005308 intermolecular recognition site; other site 1091045005309 dimerization interface [polypeptide binding]; other site 1091045005310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045005311 DNA binding residues [nucleotide binding] 1091045005312 dimerization interface [polypeptide binding]; other site 1091045005313 Histidine kinase; Region: HisKA_3; pfam07730 1091045005314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045005315 ATP binding site [chemical binding]; other site 1091045005316 Mg2+ binding site [ion binding]; other site 1091045005317 G-X-G motif; other site 1091045005318 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1091045005319 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1091045005320 putative NAD(P) binding site [chemical binding]; other site 1091045005321 putative substrate binding site [chemical binding]; other site 1091045005322 catalytic Zn binding site [ion binding]; other site 1091045005323 structural Zn binding site [ion binding]; other site 1091045005324 dimer interface [polypeptide binding]; other site 1091045005325 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1091045005326 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1091045005327 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1091045005328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091045005329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091045005330 catalytic residue [active] 1091045005331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1091045005332 YheO-like PAS domain; Region: PAS_6; pfam08348 1091045005333 HTH domain; Region: HTH_22; pfam13309 1091045005334 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1091045005335 SelR domain; Region: SelR; pfam01641 1091045005336 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1091045005337 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1091045005338 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1091045005339 catalytic site [active] 1091045005340 putative active site [active] 1091045005341 putative substrate binding site [chemical binding]; other site 1091045005342 HRDC domain; Region: HRDC; pfam00570 1091045005343 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1091045005344 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1091045005345 TPP-binding site; other site 1091045005346 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091045005347 PYR/PP interface [polypeptide binding]; other site 1091045005348 dimer interface [polypeptide binding]; other site 1091045005349 TPP binding site [chemical binding]; other site 1091045005350 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091045005351 aconitate hydratase; Validated; Region: PRK09277 1091045005352 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1091045005353 substrate binding site [chemical binding]; other site 1091045005354 ligand binding site [chemical binding]; other site 1091045005355 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1091045005356 substrate binding site [chemical binding]; other site 1091045005357 TRAM domain; Region: TRAM; cl01282 1091045005358 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1091045005359 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1091045005360 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091045005361 TrkA-N domain; Region: TrkA_N; pfam02254 1091045005362 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091045005363 TrkA-N domain; Region: TrkA_N; pfam02254 1091045005364 TrkA-C domain; Region: TrkA_C; pfam02080 1091045005365 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1091045005366 ssDNA binding site; other site 1091045005367 generic binding surface II; other site 1091045005368 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1091045005369 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1091045005370 trimer interface [polypeptide binding]; other site 1091045005371 active site 1091045005372 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1091045005373 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1091045005374 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1091045005375 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1091045005376 thymidine kinase; Provisional; Region: PRK04296 1091045005377 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1091045005378 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1091045005379 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1091045005380 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1091045005381 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1091045005382 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1091045005383 CAP-like domain; other site 1091045005384 active site 1091045005385 primary dimer interface [polypeptide binding]; other site 1091045005386 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1091045005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045005388 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1091045005389 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1091045005390 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1091045005391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045005392 Mg2+ binding site [ion binding]; other site 1091045005393 G-X-G motif; other site 1091045005394 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1091045005395 anchoring element; other site 1091045005396 dimer interface [polypeptide binding]; other site 1091045005397 ATP binding site [chemical binding]; other site 1091045005398 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1091045005399 active site 1091045005400 metal binding site [ion binding]; metal-binding site 1091045005401 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1091045005402 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1091045005403 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1091045005404 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1091045005405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091045005406 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091045005407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1091045005408 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1091045005409 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091045005410 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1091045005411 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1091045005412 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1091045005413 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1091045005414 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1091045005415 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091045005416 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091045005417 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091045005418 DNA binding residues [nucleotide binding] 1091045005419 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1091045005420 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1091045005421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091045005422 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091045005423 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1091045005424 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1091045005425 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1091045005426 active site 1091045005427 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1091045005428 catalytic triad [active] 1091045005429 dimer interface [polypeptide binding]; other site 1091045005430 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1091045005431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045005432 ATP binding site [chemical binding]; other site 1091045005433 putative Mg++ binding site [ion binding]; other site 1091045005434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045005435 nucleotide binding region [chemical binding]; other site 1091045005436 ATP-binding site [chemical binding]; other site 1091045005437 Helicase associated domain (HA2); Region: HA2; pfam04408 1091045005438 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1091045005439 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1091045005440 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091045005441 Ligand Binding Site [chemical binding]; other site 1091045005442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091045005443 Ligand Binding Site [chemical binding]; other site 1091045005444 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1091045005445 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1091045005446 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1091045005447 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1091045005448 active site 1091045005449 dimer interface [polypeptide binding]; other site 1091045005450 effector binding site; other site 1091045005451 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1091045005452 TSCPD domain; Region: TSCPD; pfam12637 1091045005453 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1091045005454 ATP cone domain; Region: ATP-cone; pfam03477 1091045005455 LexA repressor; Validated; Region: PRK00215 1091045005456 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1091045005457 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091045005458 Catalytic site [active] 1091045005459 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1091045005460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091045005461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045005462 putative Mg++ binding site [ion binding]; other site 1091045005463 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1091045005464 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1091045005465 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1091045005466 HflX GTPase family; Region: HflX; cd01878 1091045005467 G1 box; other site 1091045005468 GTP/Mg2+ binding site [chemical binding]; other site 1091045005469 Switch I region; other site 1091045005470 G2 box; other site 1091045005471 G3 box; other site 1091045005472 Switch II region; other site 1091045005473 G4 box; other site 1091045005474 G5 box; other site 1091045005475 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1091045005476 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1091045005477 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1091045005478 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1091045005479 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1091045005480 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1091045005481 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1091045005482 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1091045005483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045005484 FeS/SAM binding site; other site 1091045005485 Predicted membrane protein [Function unknown]; Region: COG1288 1091045005486 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1091045005487 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1091045005488 active site 1091045005489 catalytic residues [active] 1091045005490 hypothetical protein; Provisional; Region: PRK12705 1091045005491 KH domain; Region: KH_1; pfam00013 1091045005492 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091045005493 Zn2+ binding site [ion binding]; other site 1091045005494 Mg2+ binding site [ion binding]; other site 1091045005495 RecX family; Region: RecX; pfam02631 1091045005496 recombinase A; Provisional; Region: recA; PRK09354 1091045005497 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1091045005498 hexamer interface [polypeptide binding]; other site 1091045005499 Walker A motif; other site 1091045005500 ATP binding site [chemical binding]; other site 1091045005501 Walker B motif; other site 1091045005502 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1091045005503 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1091045005504 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1091045005505 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1091045005506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091045005507 non-specific DNA binding site [nucleotide binding]; other site 1091045005508 salt bridge; other site 1091045005509 sequence-specific DNA binding site [nucleotide binding]; other site 1091045005510 Competence-damaged protein; Region: CinA; pfam02464 1091045005511 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1091045005512 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1091045005513 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1091045005514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045005515 FeS/SAM binding site; other site 1091045005516 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1091045005517 Phosphotransferase enzyme family; Region: APH; pfam01636 1091045005518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045005519 active site 1091045005520 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1091045005521 active site 1091045005522 dimer interface [polypeptide binding]; other site 1091045005523 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1091045005524 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1091045005525 heterodimer interface [polypeptide binding]; other site 1091045005526 active site 1091045005527 FMN binding site [chemical binding]; other site 1091045005528 homodimer interface [polypeptide binding]; other site 1091045005529 substrate binding site [chemical binding]; other site 1091045005530 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1091045005531 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1091045005532 FAD binding pocket [chemical binding]; other site 1091045005533 FAD binding motif [chemical binding]; other site 1091045005534 phosphate binding motif [ion binding]; other site 1091045005535 beta-alpha-beta structure motif; other site 1091045005536 NAD binding pocket [chemical binding]; other site 1091045005537 Iron coordination center [ion binding]; other site 1091045005538 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1091045005539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091045005540 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1091045005541 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1091045005542 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091045005543 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091045005544 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1091045005545 IMP binding site; other site 1091045005546 dimer interface [polypeptide binding]; other site 1091045005547 interdomain contacts; other site 1091045005548 partial ornithine binding site; other site 1091045005549 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1091045005550 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1091045005551 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1091045005552 catalytic site [active] 1091045005553 subunit interface [polypeptide binding]; other site 1091045005554 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091045005555 dihydroorotase; Validated; Region: pyrC; PRK09357 1091045005556 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1091045005557 active site 1091045005558 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1091045005559 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1091045005560 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1091045005561 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1091045005562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045005563 active site 1091045005564 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091045005565 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091045005566 active site 1091045005567 catalytic tetrad [active] 1091045005568 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1091045005569 Isochorismatase family; Region: Isochorismatase; pfam00857 1091045005570 catalytic triad [active] 1091045005571 metal binding site [ion binding]; metal-binding site 1091045005572 conserved cis-peptide bond; other site 1091045005573 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1091045005574 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1091045005575 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1091045005576 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1091045005577 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1091045005578 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1091045005579 potential frameshift: common BLAST hit: gi|50842474|ref|YP_055701.1| endo-beta-N-acetylglucosaminidase H 1091045005580 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1091045005581 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1091045005582 dimer interface [polypeptide binding]; other site 1091045005583 TPP-binding site [chemical binding]; other site 1091045005584 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1091045005585 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1091045005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045005587 putative substrate translocation pore; other site 1091045005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045005589 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1091045005590 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1091045005591 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1091045005592 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1091045005593 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1091045005594 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1091045005595 dimer interface [polypeptide binding]; other site 1091045005596 active site 1091045005597 CoA binding pocket [chemical binding]; other site 1091045005598 acyl carrier protein; Provisional; Region: acpP; PRK00982 1091045005599 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1091045005600 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1091045005601 dimer interface [polypeptide binding]; other site 1091045005602 active site 1091045005603 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1091045005604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1091045005605 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091045005606 catalytic residue [active] 1091045005607 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1091045005608 metal ion-dependent adhesion site (MIDAS); other site 1091045005609 hypothetical protein; Provisional; Region: PRK13685 1091045005610 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1091045005611 metal ion-dependent adhesion site (MIDAS); other site 1091045005612 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 1091045005613 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091045005614 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1091045005615 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091045005616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045005617 Walker A motif; other site 1091045005618 ATP binding site [chemical binding]; other site 1091045005619 Walker B motif; other site 1091045005620 arginine finger; other site 1091045005621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1091045005622 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1091045005623 active site 1091045005624 motif I; other site 1091045005625 motif II; other site 1091045005626 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091045005627 potential protein location (hypothetical protein TIIST44_09785 [Propionibacterium acnes ATCC 11828]) that overlaps RNA (tRNA-M) 1091045005628 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1091045005629 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1091045005630 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1091045005631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091045005632 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1091045005633 inhibitor-cofactor binding pocket; inhibition site 1091045005634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045005635 catalytic residue [active] 1091045005636 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1091045005637 predicted active site [active] 1091045005638 catalytic triad [active] 1091045005639 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1091045005640 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1091045005641 active site 1091045005642 multimer interface [polypeptide binding]; other site 1091045005643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045005644 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1091045005645 DNA-binding site [nucleotide binding]; DNA binding site 1091045005646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091045005647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045005648 homodimer interface [polypeptide binding]; other site 1091045005649 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1091045005650 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091045005651 dimer interface [polypeptide binding]; other site 1091045005652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045005653 catalytic residue [active] 1091045005654 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1091045005655 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1091045005656 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1091045005657 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1091045005658 active site 1091045005659 homotetramer interface [polypeptide binding]; other site 1091045005660 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1091045005661 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1091045005662 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1091045005663 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1091045005664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091045005665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091045005666 DNA binding residues [nucleotide binding] 1091045005667 DNA primase; Validated; Region: dnaG; PRK05667 1091045005668 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1091045005669 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1091045005670 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1091045005671 active site 1091045005672 metal binding site [ion binding]; metal-binding site 1091045005673 interdomain interaction site; other site 1091045005674 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1091045005675 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1091045005676 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1091045005677 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1091045005678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091045005679 Zn2+ binding site [ion binding]; other site 1091045005680 Mg2+ binding site [ion binding]; other site 1091045005681 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1091045005682 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1091045005683 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1091045005684 FMN binding site [chemical binding]; other site 1091045005685 active site 1091045005686 catalytic residues [active] 1091045005687 substrate binding site [chemical binding]; other site 1091045005688 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1091045005689 putative FMN binding site [chemical binding]; other site 1091045005690 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1091045005691 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1091045005692 putative dimer interface [polypeptide binding]; other site 1091045005693 active site pocket [active] 1091045005694 putative cataytic base [active] 1091045005695 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1091045005696 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1091045005697 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045005698 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1091045005699 L-aspartate oxidase; Provisional; Region: PRK06175 1091045005700 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1091045005701 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1091045005702 putative dimer interface [polypeptide binding]; other site 1091045005703 distal heme binding site [chemical binding]; other site 1091045005704 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1091045005705 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091045005706 motif 1; other site 1091045005707 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1091045005708 active site 1091045005709 motif 2; other site 1091045005710 motif 3; other site 1091045005711 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1091045005712 anticodon binding site; other site 1091045005713 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1091045005714 metal binding site 2 [ion binding]; metal-binding site 1091045005715 putative DNA binding helix; other site 1091045005716 metal binding site 1 [ion binding]; metal-binding site 1091045005717 dimer interface [polypeptide binding]; other site 1091045005718 structural Zn2+ binding site [ion binding]; other site 1091045005719 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045005720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045005721 active site 1091045005722 phosphorylation site [posttranslational modification] 1091045005723 intermolecular recognition site; other site 1091045005724 dimerization interface [polypeptide binding]; other site 1091045005725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045005726 DNA binding residues [nucleotide binding] 1091045005727 dimerization interface [polypeptide binding]; other site 1091045005728 potential frameshift: common BLAST hit: gi|50842429|ref|YP_055656.1| putative histidine kinase 1091045005729 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1091045005730 Recombination protein O N terminal; Region: RecO_N; pfam11967 1091045005731 Recombination protein O C terminal; Region: RecO_C; pfam02565 1091045005732 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1091045005733 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1091045005734 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1091045005735 catalytic residue [active] 1091045005736 putative FPP diphosphate binding site; other site 1091045005737 putative FPP binding hydrophobic cleft; other site 1091045005738 dimer interface [polypeptide binding]; other site 1091045005739 putative IPP diphosphate binding site; other site 1091045005740 2-isopropylmalate synthase; Validated; Region: PRK03739 1091045005741 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1091045005742 active site 1091045005743 catalytic residues [active] 1091045005744 metal binding site [ion binding]; metal-binding site 1091045005745 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1091045005746 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1091045005747 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1091045005748 active site 1091045005749 GTPase Era; Reviewed; Region: era; PRK00089 1091045005750 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1091045005751 G1 box; other site 1091045005752 GTP/Mg2+ binding site [chemical binding]; other site 1091045005753 Switch I region; other site 1091045005754 G2 box; other site 1091045005755 Switch II region; other site 1091045005756 G3 box; other site 1091045005757 G4 box; other site 1091045005758 G5 box; other site 1091045005759 KH domain; Region: KH_2; pfam07650 1091045005760 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1091045005761 Domain of unknown function DUF21; Region: DUF21; pfam01595 1091045005762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091045005763 Transporter associated domain; Region: CorC_HlyC; smart01091 1091045005764 metal-binding heat shock protein; Provisional; Region: PRK00016 1091045005765 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1091045005766 PhoH-like protein; Region: PhoH; pfam02562 1091045005767 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1091045005768 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1091045005769 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1091045005770 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1091045005771 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1091045005772 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1091045005773 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1091045005774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045005775 Walker A/P-loop; other site 1091045005776 ATP binding site [chemical binding]; other site 1091045005777 Q-loop/lid; other site 1091045005778 ABC transporter signature motif; other site 1091045005779 Walker B; other site 1091045005780 D-loop; other site 1091045005781 H-loop/switch region; other site 1091045005782 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1091045005783 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091045005784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045005785 active site 1091045005786 phosphorylation site [posttranslational modification] 1091045005787 intermolecular recognition site; other site 1091045005788 dimerization interface [polypeptide binding]; other site 1091045005789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091045005790 DNA binding residues [nucleotide binding] 1091045005791 dimerization interface [polypeptide binding]; other site 1091045005792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1091045005793 Histidine kinase; Region: HisKA_3; pfam07730 1091045005794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091045005795 ATP binding site [chemical binding]; other site 1091045005796 Mg2+ binding site [ion binding]; other site 1091045005797 G-X-G motif; other site 1091045005798 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1091045005799 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1091045005800 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1091045005801 EamA-like transporter family; Region: EamA; pfam00892 1091045005802 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1091045005803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1091045005804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045005805 ATP binding site [chemical binding]; other site 1091045005806 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1091045005807 putative Mg++ binding site [ion binding]; other site 1091045005808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045005809 nucleotide binding region [chemical binding]; other site 1091045005810 ATP-binding site [chemical binding]; other site 1091045005811 Predicted membrane protein [Function unknown]; Region: COG2259 1091045005812 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1091045005813 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1091045005814 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1091045005815 active site 1091045005816 P-loop; other site 1091045005817 phosphorylation site [posttranslational modification] 1091045005818 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1091045005819 active site 1091045005820 phosphorylation site [posttranslational modification] 1091045005821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1091045005822 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1091045005823 putative NAD(P) binding site [chemical binding]; other site 1091045005824 catalytic Zn binding site [ion binding]; other site 1091045005825 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1091045005826 RNA methyltransferase, RsmE family; Region: TIGR00046 1091045005827 chaperone protein DnaJ; Provisional; Region: PRK14278 1091045005828 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091045005829 HSP70 interaction site [polypeptide binding]; other site 1091045005830 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1091045005831 Zn binding sites [ion binding]; other site 1091045005832 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1091045005833 dimer interface [polypeptide binding]; other site 1091045005834 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1091045005835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091045005836 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091045005837 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1091045005838 active site 1091045005839 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1091045005840 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1091045005841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045005842 FeS/SAM binding site; other site 1091045005843 HemN C-terminal domain; Region: HemN_C; pfam06969 1091045005844 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091045005845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091045005846 acyl-activating enzyme (AAE) consensus motif; other site 1091045005847 CoA binding site [chemical binding]; other site 1091045005848 Rhomboid family; Region: Rhomboid; pfam01694 1091045005849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091045005850 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1091045005851 substrate binding site [chemical binding]; other site 1091045005852 oxyanion hole (OAH) forming residues; other site 1091045005853 trimer interface [polypeptide binding]; other site 1091045005854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091045005855 acyl-activating enzyme (AAE) consensus motif; other site 1091045005856 AMP binding site [chemical binding]; other site 1091045005857 active site 1091045005858 CoA binding site [chemical binding]; other site 1091045005859 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1091045005860 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1091045005861 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1091045005862 dimer interface [polypeptide binding]; other site 1091045005863 tetramer interface [polypeptide binding]; other site 1091045005864 PYR/PP interface [polypeptide binding]; other site 1091045005865 TPP binding site [chemical binding]; other site 1091045005866 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1091045005867 TPP-binding site [chemical binding]; other site 1091045005868 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1091045005869 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1091045005870 active site 1091045005871 GTP-binding protein LepA; Provisional; Region: PRK05433 1091045005872 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1091045005873 G1 box; other site 1091045005874 putative GEF interaction site [polypeptide binding]; other site 1091045005875 GTP/Mg2+ binding site [chemical binding]; other site 1091045005876 Switch I region; other site 1091045005877 G2 box; other site 1091045005878 G3 box; other site 1091045005879 Switch II region; other site 1091045005880 G4 box; other site 1091045005881 G5 box; other site 1091045005882 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1091045005883 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1091045005884 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1091045005885 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1091045005886 active site 1091045005887 catalytic site [active] 1091045005888 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1091045005889 hypothetical protein; Reviewed; Region: PRK07914 1091045005890 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1091045005891 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1091045005892 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045005893 ATP binding site [chemical binding]; other site 1091045005894 putative Mg++ binding site [ion binding]; other site 1091045005895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1091045005896 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1091045005897 Competence protein; Region: Competence; pfam03772 1091045005898 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1091045005899 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091045005900 SLBB domain; Region: SLBB; pfam10531 1091045005901 comEA protein; Region: comE; TIGR01259 1091045005902 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1091045005903 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1091045005904 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1091045005905 HIGH motif; other site 1091045005906 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1091045005907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091045005908 active site 1091045005909 KMSKS motif; other site 1091045005910 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1091045005911 tRNA binding surface [nucleotide binding]; other site 1091045005912 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1091045005913 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1091045005914 malate dehydrogenase; Provisional; Region: PRK13529 1091045005915 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1091045005916 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1091045005917 NAD(P) binding site [chemical binding]; other site 1091045005918 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1091045005919 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1091045005920 dimer interface [polypeptide binding]; other site 1091045005921 NAD binding site [chemical binding]; other site 1091045005922 substrate binding site [chemical binding]; other site 1091045005923 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091045005924 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1091045005925 thiamine phosphate binding site [chemical binding]; other site 1091045005926 active site 1091045005927 pyrophosphate binding site [ion binding]; other site 1091045005928 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1091045005929 substrate binding site [chemical binding]; other site 1091045005930 multimerization interface [polypeptide binding]; other site 1091045005931 ATP binding site [chemical binding]; other site 1091045005932 benzoate transport; Region: 2A0115; TIGR00895 1091045005933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045005934 putative substrate translocation pore; other site 1091045005935 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091045005936 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1091045005937 substrate binding site [chemical binding]; other site 1091045005938 ATP binding site [chemical binding]; other site 1091045005939 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1091045005940 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1091045005941 intersubunit interface [polypeptide binding]; other site 1091045005942 active site 1091045005943 Zn2+ binding site [ion binding]; other site 1091045005944 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1091045005945 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1091045005946 AP (apurinic/apyrimidinic) site pocket; other site 1091045005947 DNA interaction; other site 1091045005948 Metal-binding active site; metal-binding site 1091045005949 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1091045005950 active site 1091045005951 dimer interface [polypeptide binding]; other site 1091045005952 magnesium binding site [ion binding]; other site 1091045005953 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1091045005954 active site 1091045005955 substrate binding pocket [chemical binding]; other site 1091045005956 homodimer interaction site [polypeptide binding]; other site 1091045005957 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1091045005958 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1091045005959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091045005960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045005961 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1091045005962 Flavin Reductases; Region: FlaRed; cl00801 1091045005963 Oligomerisation domain; Region: Oligomerisation; pfam02410 1091045005964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045005965 catalytic core [active] 1091045005966 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1091045005967 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1091045005968 active site 1091045005969 (T/H)XGH motif; other site 1091045005970 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1091045005971 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1091045005972 putative catalytic cysteine [active] 1091045005973 gamma-glutamyl kinase; Provisional; Region: PRK05429 1091045005974 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1091045005975 nucleotide binding site [chemical binding]; other site 1091045005976 homotetrameric interface [polypeptide binding]; other site 1091045005977 putative phosphate binding site [ion binding]; other site 1091045005978 putative allosteric binding site; other site 1091045005979 PUA domain; Region: PUA; pfam01472 1091045005980 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1091045005981 GTP1/OBG; Region: GTP1_OBG; pfam01018 1091045005982 Obg GTPase; Region: Obg; cd01898 1091045005983 G1 box; other site 1091045005984 GTP/Mg2+ binding site [chemical binding]; other site 1091045005985 Switch I region; other site 1091045005986 G2 box; other site 1091045005987 G3 box; other site 1091045005988 Switch II region; other site 1091045005989 G4 box; other site 1091045005990 G5 box; other site 1091045005991 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1091045005992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045005993 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045005994 putative substrate translocation pore; other site 1091045005995 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1091045005996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091045005997 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1091045005998 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1091045005999 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1091045006000 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1091045006001 homodimer interface [polypeptide binding]; other site 1091045006002 oligonucleotide binding site [chemical binding]; other site 1091045006003 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1091045006004 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1091045006005 potential frameshift: common BLAST hit: gi|50842311|ref|YP_055538.1| Fe-S oxidoreductase family protein 2 1091045006006 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1091045006007 active site 1091045006008 multimer interface [polypeptide binding]; other site 1091045006009 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1091045006010 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1091045006011 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1091045006012 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1091045006013 triosephosphate isomerase; Provisional; Region: PRK14567 1091045006014 substrate binding site [chemical binding]; other site 1091045006015 dimer interface [polypeptide binding]; other site 1091045006016 catalytic triad [active] 1091045006017 Phosphoglycerate kinase; Region: PGK; pfam00162 1091045006018 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1091045006019 substrate binding site [chemical binding]; other site 1091045006020 hinge regions; other site 1091045006021 ADP binding site [chemical binding]; other site 1091045006022 catalytic site [active] 1091045006023 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1091045006024 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1091045006025 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1091045006026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1091045006027 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1091045006028 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1091045006029 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1091045006030 phosphate binding site [ion binding]; other site 1091045006031 putative substrate binding pocket [chemical binding]; other site 1091045006032 dimer interface [polypeptide binding]; other site 1091045006033 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1091045006034 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1091045006035 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1091045006036 GIY-YIG motif/motif A; other site 1091045006037 active site 1091045006038 catalytic site [active] 1091045006039 putative DNA binding site [nucleotide binding]; other site 1091045006040 metal binding site [ion binding]; metal-binding site 1091045006041 UvrB/uvrC motif; Region: UVR; pfam02151 1091045006042 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1091045006043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091045006044 catalytic core [active] 1091045006045 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1091045006046 iron-sulfur cluster [ion binding]; other site 1091045006047 [2Fe-2S] cluster binding site [ion binding]; other site 1091045006048 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1091045006049 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1091045006050 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1091045006051 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1091045006052 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1091045006053 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1091045006054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1091045006055 Integral membrane protein TerC family; Region: TerC; cl10468 1091045006056 excinuclease ABC subunit B; Provisional; Region: PRK05298 1091045006057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091045006058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091045006059 nucleotide binding region [chemical binding]; other site 1091045006060 ATP-binding site [chemical binding]; other site 1091045006061 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1091045006062 UvrB/uvrC motif; Region: UVR; pfam02151 1091045006063 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1091045006064 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1091045006065 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045006066 intersubunit interface [polypeptide binding]; other site 1091045006067 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1091045006068 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045006069 ABC-ATPase subunit interface; other site 1091045006070 dimer interface [polypeptide binding]; other site 1091045006071 putative PBP binding regions; other site 1091045006072 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1091045006073 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045006074 Walker A/P-loop; other site 1091045006075 ATP binding site [chemical binding]; other site 1091045006076 Q-loop/lid; other site 1091045006077 ABC transporter signature motif; other site 1091045006078 Walker B; other site 1091045006079 D-loop; other site 1091045006080 H-loop/switch region; other site 1091045006081 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1091045006082 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1091045006083 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1091045006084 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1091045006085 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1091045006086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1091045006087 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1091045006088 metal ion-dependent adhesion site (MIDAS); other site 1091045006089 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1091045006090 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1091045006091 Htaa; Region: HtaA; pfam04213 1091045006092 Htaa; Region: HtaA; pfam04213 1091045006093 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1091045006094 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1091045006095 ATP-binding [chemical binding]; other site 1091045006096 CoA-binding site [chemical binding]; other site 1091045006097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045006098 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1091045006099 Walker A/P-loop; other site 1091045006100 ATP binding site [chemical binding]; other site 1091045006101 Q-loop/lid; other site 1091045006102 ABC transporter signature motif; other site 1091045006103 Walker B; other site 1091045006104 D-loop; other site 1091045006105 H-loop/switch region; other site 1091045006106 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1091045006107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091045006108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045006109 Walker A/P-loop; other site 1091045006110 ATP binding site [chemical binding]; other site 1091045006111 Q-loop/lid; other site 1091045006112 ABC transporter signature motif; other site 1091045006113 Walker B; other site 1091045006114 D-loop; other site 1091045006115 H-loop/switch region; other site 1091045006116 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1091045006117 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045006118 Walker A/P-loop; other site 1091045006119 ATP binding site [chemical binding]; other site 1091045006120 Q-loop/lid; other site 1091045006121 ABC transporter signature motif; other site 1091045006122 Walker B; other site 1091045006123 D-loop; other site 1091045006124 H-loop/switch region; other site 1091045006125 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1091045006126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045006127 ABC-ATPase subunit interface; other site 1091045006128 dimer interface [polypeptide binding]; other site 1091045006129 putative PBP binding regions; other site 1091045006130 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1091045006131 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045006132 intersubunit interface [polypeptide binding]; other site 1091045006133 Htaa; Region: HtaA; pfam04213 1091045006134 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1091045006135 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1091045006136 RNA binding site [nucleotide binding]; other site 1091045006137 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1091045006138 RNA binding site [nucleotide binding]; other site 1091045006139 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1091045006140 RNA binding site [nucleotide binding]; other site 1091045006141 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1091045006142 RNA binding site [nucleotide binding]; other site 1091045006143 domain interface; other site 1091045006144 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1091045006145 active site 1091045006146 putative catalytic site [active] 1091045006147 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091045006148 FAD binding domain; Region: FAD_binding_4; pfam01565 1091045006149 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1091045006150 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1091045006151 DNA polymerase I; Provisional; Region: PRK05755 1091045006152 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1091045006153 active site 1091045006154 metal binding site 1 [ion binding]; metal-binding site 1091045006155 putative 5' ssDNA interaction site; other site 1091045006156 metal binding site 3; metal-binding site 1091045006157 metal binding site 2 [ion binding]; metal-binding site 1091045006158 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1091045006159 putative DNA binding site [nucleotide binding]; other site 1091045006160 putative metal binding site [ion binding]; other site 1091045006161 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1091045006162 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1091045006163 active site 1091045006164 DNA binding site [nucleotide binding] 1091045006165 catalytic site [active] 1091045006166 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1091045006167 CoenzymeA binding site [chemical binding]; other site 1091045006168 subunit interaction site [polypeptide binding]; other site 1091045006169 PHB binding site; other site 1091045006170 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1091045006171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091045006172 active site 1091045006173 phosphorylation site [posttranslational modification] 1091045006174 intermolecular recognition site; other site 1091045006175 dimerization interface [polypeptide binding]; other site 1091045006176 ANTAR domain; Region: ANTAR; pfam03861 1091045006177 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1091045006178 CrcB-like protein; Region: CRCB; pfam02537 1091045006179 pyruvate kinase; Provisional; Region: PRK06247 1091045006180 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1091045006181 active site 1091045006182 domain interfaces; other site 1091045006183 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1091045006184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091045006185 RNA binding surface [nucleotide binding]; other site 1091045006186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1091045006187 active site 1091045006188 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1091045006189 lipoprotein signal peptidase; Provisional; Region: PRK14787 1091045006190 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1091045006191 DivIVA protein; Region: DivIVA; pfam05103 1091045006192 DivIVA domain; Region: DivI1A_domain; TIGR03544 1091045006193 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1091045006194 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1091045006195 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1091045006196 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1091045006197 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1091045006198 nucleotide binding site [chemical binding]; other site 1091045006199 SulA interaction site; other site 1091045006200 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1091045006201 Cell division protein FtsQ; Region: FtsQ; pfam03799 1091045006202 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1091045006203 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091045006204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091045006205 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091045006206 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1091045006207 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1091045006208 active site 1091045006209 homodimer interface [polypeptide binding]; other site 1091045006210 cell division protein FtsW; Region: ftsW; TIGR02614 1091045006211 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1091045006212 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091045006213 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091045006214 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1091045006215 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1091045006216 Mg++ binding site [ion binding]; other site 1091045006217 putative catalytic motif [active] 1091045006218 putative substrate binding site [chemical binding]; other site 1091045006219 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1091045006220 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091045006221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091045006222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091045006223 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1091045006224 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091045006225 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091045006226 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091045006227 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1091045006228 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1091045006229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091045006230 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1091045006231 MraW methylase family; Region: Methyltransf_5; cl17771 1091045006232 cell division protein MraZ; Reviewed; Region: PRK00326 1091045006233 MraZ protein; Region: MraZ; pfam02381 1091045006234 MraZ protein; Region: MraZ; pfam02381 1091045006235 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091045006236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091045006237 ATP binding site [chemical binding]; other site 1091045006238 Walker A motif; other site 1091045006239 Walker B motif; other site 1091045006240 arginine finger; other site 1091045006241 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1091045006242 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091045006243 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091045006244 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091045006245 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1091045006246 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1091045006247 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1091045006248 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1091045006249 lipoyl attachment site [posttranslational modification]; other site 1091045006250 glycine dehydrogenase; Provisional; Region: PRK05367 1091045006251 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1091045006252 tetramer interface [polypeptide binding]; other site 1091045006253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045006254 catalytic residue [active] 1091045006255 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1091045006256 tetramer interface [polypeptide binding]; other site 1091045006257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045006258 catalytic residue [active] 1091045006259 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091045006260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045006261 DNA-binding site [nucleotide binding]; DNA binding site 1091045006262 FCD domain; Region: FCD; pfam07729 1091045006263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045006264 DNA-binding site [nucleotide binding]; DNA binding site 1091045006265 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1091045006266 FCD domain; Region: FCD; pfam07729 1091045006267 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1091045006268 ATP-binding site [chemical binding]; other site 1091045006269 Gluconate-6-phosphate binding site [chemical binding]; other site 1091045006270 GntP family permease; Region: GntP_permease; pfam02447 1091045006271 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1091045006272 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1091045006273 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1091045006274 putative dimer interface [polypeptide binding]; other site 1091045006275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091045006276 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1091045006277 catalytic site [active] 1091045006278 Part of AAA domain; Region: AAA_19; pfam13245 1091045006279 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1091045006280 Family description; Region: UvrD_C_2; pfam13538 1091045006281 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1091045006282 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091045006283 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091045006284 substrate binding pocket [chemical binding]; other site 1091045006285 chain length determination region; other site 1091045006286 substrate-Mg2+ binding site; other site 1091045006287 catalytic residues [active] 1091045006288 aspartate-rich region 1; other site 1091045006289 active site lid residues [active] 1091045006290 aspartate-rich region 2; other site 1091045006291 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1091045006292 putative RNAase interaction site [polypeptide binding]; other site 1091045006293 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1091045006294 active site 1091045006295 barstar interaction site; other site 1091045006296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091045006297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091045006298 active site 1091045006299 ATP binding site [chemical binding]; other site 1091045006300 substrate binding site [chemical binding]; other site 1091045006301 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091045006302 substrate binding site [chemical binding]; other site 1091045006303 activation loop (A-loop); other site 1091045006304 activation loop (A-loop); other site 1091045006305 EamA-like transporter family; Region: EamA; pfam00892 1091045006306 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1091045006307 EamA-like transporter family; Region: EamA; pfam00892 1091045006308 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1091045006309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1091045006310 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1091045006311 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1091045006312 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091045006313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091045006314 putative acyl-acceptor binding pocket; other site 1091045006315 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1091045006316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1091045006317 nucleotide binding site [chemical binding]; other site 1091045006318 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1091045006319 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091045006320 hypothetical protein; Validated; Region: PRK07883 1091045006321 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1091045006322 active site 1091045006323 catalytic site [active] 1091045006324 substrate binding site [chemical binding]; other site 1091045006325 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1091045006326 GIY-YIG motif/motif A; other site 1091045006327 active site 1091045006328 catalytic site [active] 1091045006329 putative DNA binding site [nucleotide binding]; other site 1091045006330 metal binding site [ion binding]; metal-binding site 1091045006331 Rhomboid family; Region: Rhomboid; cl11446 1091045006332 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1091045006333 active site 1091045006334 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1091045006335 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1091045006336 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1091045006337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1091045006338 active site 1091045006339 phosphorylation site [posttranslational modification] 1091045006340 intermolecular recognition site; other site 1091045006341 dimerization interface [polypeptide binding]; other site 1091045006342 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1091045006343 Subunit I/III interface [polypeptide binding]; other site 1091045006344 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1091045006345 Cytochrome c; Region: Cytochrom_C; pfam00034 1091045006346 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1091045006347 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1091045006348 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1091045006349 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1091045006350 iron-sulfur cluster [ion binding]; other site 1091045006351 [2Fe-2S] cluster binding site [ion binding]; other site 1091045006352 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1091045006353 heme bL binding site [chemical binding]; other site 1091045006354 interchain domain interface [polypeptide binding]; other site 1091045006355 intrachain domain interface; other site 1091045006356 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1091045006357 heme bH binding site [chemical binding]; other site 1091045006358 Qo binding site; other site 1091045006359 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1091045006360 active site 1091045006361 DNA binding site [nucleotide binding] 1091045006362 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1091045006363 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045006364 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1091045006365 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091045006366 phosphate binding site [ion binding]; other site 1091045006367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091045006368 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1091045006369 NAD(P) binding site [chemical binding]; other site 1091045006370 active site 1091045006371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091045006372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045006373 Walker A/P-loop; other site 1091045006374 ATP binding site [chemical binding]; other site 1091045006375 Q-loop/lid; other site 1091045006376 ABC transporter signature motif; other site 1091045006377 Walker B; other site 1091045006378 D-loop; other site 1091045006379 H-loop/switch region; other site 1091045006380 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1091045006381 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1091045006382 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1091045006383 D-pathway; other site 1091045006384 Putative ubiquinol binding site [chemical binding]; other site 1091045006385 Low-spin heme (heme b) binding site [chemical binding]; other site 1091045006386 Putative water exit pathway; other site 1091045006387 Binuclear center (heme o3/CuB) [ion binding]; other site 1091045006388 K-pathway; other site 1091045006389 Putative proton exit pathway; other site 1091045006390 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1091045006391 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1091045006392 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1091045006393 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1091045006394 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1091045006395 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1091045006396 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1091045006397 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1091045006398 interface (dimer of trimers) [polypeptide binding]; other site 1091045006399 Substrate-binding/catalytic site; other site 1091045006400 Zn-binding sites [ion binding]; other site 1091045006401 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1091045006402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091045006403 E3 interaction surface; other site 1091045006404 lipoyl attachment site [posttranslational modification]; other site 1091045006405 e3 binding domain; Region: E3_binding; pfam02817 1091045006406 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091045006407 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1091045006408 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1091045006409 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091045006410 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091045006411 metal-binding site [ion binding] 1091045006412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091045006413 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091045006414 lipoyl synthase; Provisional; Region: PRK05481 1091045006415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091045006416 FeS/SAM binding site; other site 1091045006417 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1091045006418 putative sialic acid transporter; Provisional; Region: PRK03893 1091045006419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045006420 putative substrate translocation pore; other site 1091045006421 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1091045006422 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1091045006423 Asp-box motif; other site 1091045006424 catalytic site [active] 1091045006425 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1091045006426 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 1091045006427 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1091045006428 Asp-box motif; other site 1091045006429 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1091045006430 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1091045006431 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1091045006432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045006433 ABC transporter; Region: ABC_tran_2; pfam12848 1091045006434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091045006435 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1091045006436 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1091045006437 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1091045006438 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045006439 Walker A/P-loop; other site 1091045006440 ATP binding site [chemical binding]; other site 1091045006441 Q-loop/lid; other site 1091045006442 ABC transporter signature motif; other site 1091045006443 Walker B; other site 1091045006444 D-loop; other site 1091045006445 H-loop/switch region; other site 1091045006446 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1091045006447 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045006448 dimer interface [polypeptide binding]; other site 1091045006449 putative PBP binding regions; other site 1091045006450 ABC-ATPase subunit interface; other site 1091045006451 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045006452 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1091045006453 intersubunit interface [polypeptide binding]; other site 1091045006454 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1091045006455 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 1091045006456 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1091045006457 sugar binding site [chemical binding]; other site 1091045006458 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1091045006459 HPr interaction site; other site 1091045006460 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1091045006461 active site 1091045006462 phosphorylation site [posttranslational modification] 1091045006463 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1091045006464 active site turn [active] 1091045006465 phosphorylation site [posttranslational modification] 1091045006466 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1091045006467 active site turn [active] 1091045006468 phosphorylation site [posttranslational modification] 1091045006469 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1091045006470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1091045006471 DNA-binding site [nucleotide binding]; DNA binding site 1091045006472 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1091045006473 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1091045006474 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1091045006475 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091045006476 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091045006477 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091045006478 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1091045006479 RDD family; Region: RDD; pfam06271 1091045006480 glutamine synthetase, type I; Region: GlnA; TIGR00653 1091045006481 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1091045006482 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1091045006483 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1091045006484 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1091045006485 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1091045006486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1091045006487 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1091045006488 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1091045006489 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1091045006490 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1091045006491 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1091045006492 metal binding triad; other site 1091045006493 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1091045006494 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1091045006495 metal binding triad; other site 1091045006496 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1091045006497 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1091045006498 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1091045006499 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1091045006500 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1091045006501 active site 1091045006502 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1091045006503 carbon starvation protein A; Provisional; Region: PRK15015 1091045006504 Carbon starvation protein CstA; Region: CstA; pfam02554 1091045006505 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1091045006506 Protein of unknown function (DUF466); Region: DUF466; cl01082 1091045006507 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1091045006508 dimer interface [polypeptide binding]; other site 1091045006509 [2Fe-2S] cluster binding site [ion binding]; other site 1091045006510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091045006511 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1091045006512 Walker A/P-loop; other site 1091045006513 ATP binding site [chemical binding]; other site 1091045006514 Q-loop/lid; other site 1091045006515 ABC transporter signature motif; other site 1091045006516 Walker B; other site 1091045006517 D-loop; other site 1091045006518 H-loop/switch region; other site 1091045006519 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1091045006520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091045006521 ABC-ATPase subunit interface; other site 1091045006522 dimer interface [polypeptide binding]; other site 1091045006523 putative PBP binding regions; other site 1091045006524 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1091045006525 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045006526 intersubunit interface [polypeptide binding]; other site 1091045006527 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 1091045006528 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1091045006529 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1091045006530 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1091045006531 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1091045006532 Putative zinc ribbon domain; Region: DUF164; pfam02591 1091045006533 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1091045006534 proline aminopeptidase P II; Provisional; Region: PRK10879 1091045006535 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1091045006536 active site 1091045006537 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1091045006538 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1091045006539 MgtE intracellular N domain; Region: MgtE_N; smart00924 1091045006540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1091045006541 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1091045006542 Domain of unknown function DUF59; Region: DUF59; pfam01883 1091045006543 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1091045006544 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1091045006545 Walker A motif; other site 1091045006546 sec-independent translocase; Provisional; Region: PRK01371 1091045006547 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1091045006548 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1091045006549 dimer interface [polypeptide binding]; other site 1091045006550 active site 1091045006551 catalytic residue [active] 1091045006552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091045006553 S-adenosylmethionine binding site [chemical binding]; other site 1091045006554 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1091045006555 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1091045006556 ligand binding site; other site 1091045006557 oligomer interface; other site 1091045006558 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1091045006559 dimer interface [polypeptide binding]; other site 1091045006560 N-terminal domain interface [polypeptide binding]; other site 1091045006561 sulfate 1 binding site; other site 1091045006562 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1091045006563 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091045006564 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1091045006565 DivIVA domain; Region: DivI1A_domain; TIGR03544 1091045006566 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1091045006567 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1091045006568 metal binding site [ion binding]; metal-binding site 1091045006569 putative dimer interface [polypeptide binding]; other site 1091045006570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045006571 metabolite-proton symporter; Region: 2A0106; TIGR00883 1091045006572 putative substrate translocation pore; other site 1091045006573 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1091045006574 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1091045006575 Amidinotransferase; Region: Amidinotransf; cl12043 1091045006576 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1091045006577 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1091045006578 putative trimer interface [polypeptide binding]; other site 1091045006579 putative CoA binding site [chemical binding]; other site 1091045006580 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1091045006581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091045006582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091045006583 homodimer interface [polypeptide binding]; other site 1091045006584 catalytic residue [active] 1091045006585 Ferredoxin [Energy production and conversion]; Region: COG1146 1091045006586 4Fe-4S binding domain; Region: Fer4; pfam00037 1091045006587 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1091045006588 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1091045006589 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1091045006590 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1091045006591 ligand binding site [chemical binding]; other site 1091045006592 homodimer interface [polypeptide binding]; other site 1091045006593 NAD(P) binding site [chemical binding]; other site 1091045006594 trimer interface B [polypeptide binding]; other site 1091045006595 trimer interface A [polypeptide binding]; other site 1091045006596 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1091045006597 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1091045006598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091045006599 Coenzyme A binding pocket [chemical binding]; other site 1091045006600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1091045006601 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1091045006602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091045006603 active site 1091045006604 dihydroxyacetone kinase; Provisional; Region: PRK14479 1091045006605 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1091045006606 DAK2 domain; Region: Dak2; pfam02734 1091045006607 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1091045006608 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1091045006609 putative NAD(P) binding site [chemical binding]; other site 1091045006610 catalytic Zn binding site [ion binding]; other site 1091045006611 Proline dehydrogenase; Region: Pro_dh; cl03282 1091045006612 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1091045006613 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091045006614 Glutamate binding site [chemical binding]; other site 1091045006615 NAD binding site [chemical binding]; other site 1091045006616 catalytic residues [active] 1091045006617 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1091045006618 Na binding site [ion binding]; other site 1091045006619 Isochorismatase family; Region: Isochorismatase; pfam00857 1091045006620 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1091045006621 catalytic triad [active] 1091045006622 conserved cis-peptide bond; other site 1091045006623 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1091045006624 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1091045006625 intersubunit interface [polypeptide binding]; other site 1091045006626 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1091045006627 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1091045006628 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1091045006629 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1091045006630 dimer interface [polypeptide binding]; other site 1091045006631 ABC-ATPase subunit interface; other site 1091045006632 FtsX-like permease family; Region: FtsX; pfam02687 1091045006633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091045006634 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091045006635 Walker A/P-loop; other site 1091045006636 ATP binding site [chemical binding]; other site 1091045006637 Q-loop/lid; other site 1091045006638 ABC transporter signature motif; other site 1091045006639 Walker B; other site 1091045006640 D-loop; other site 1091045006641 H-loop/switch region; other site 1091045006642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091045006643 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1091045006644 substrate binding pocket [chemical binding]; other site 1091045006645 membrane-bound complex binding site; other site 1091045006646 hinge residues; other site 1091045006647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091045006648 dimer interface [polypeptide binding]; other site 1091045006649 ABC-ATPase subunit interface; other site 1091045006650 putative PBP binding loops; other site 1091045006651 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1091045006652 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1091045006653 Walker A/P-loop; other site 1091045006654 ATP binding site [chemical binding]; other site 1091045006655 Q-loop/lid; other site 1091045006656 ABC transporter signature motif; other site 1091045006657 Walker B; other site 1091045006658 D-loop; other site 1091045006659 H-loop/switch region; other site 1091045006660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091045006661 RNA binding surface [nucleotide binding]; other site 1091045006662 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1091045006663 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1091045006664 active site 1091045006665 catalytic triad [active] 1091045006666 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1091045006667 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1091045006668 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1091045006669 Walker A; other site 1091045006670 G1 box; other site 1091045006671 GTP/Mg2+ binding site [chemical binding]; other site 1091045006672 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1091045006673 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1091045006674 active site 1091045006675 substrate binding site [chemical binding]; other site 1091045006676 coenzyme B12 binding site [chemical binding]; other site 1091045006677 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1091045006678 B12 binding site [chemical binding]; other site 1091045006679 cobalt ligand [ion binding]; other site 1091045006680 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1091045006681 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1091045006682 heterodimer interface [polypeptide binding]; other site 1091045006683 substrate interaction site [chemical binding]; other site 1091045006684 monoglyceride lipase; Provisional; Region: PHA02857 1091045006685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091045006686 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1091045006687 beta-alpha-beta structure motif; other site 1091045006688 NAD binding pocket [chemical binding]; other site 1091045006689 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1091045006690 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091045006691 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1091045006692 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1091045006693 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1091045006694 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1091045006695 active site 1091045006696 catalytic site [active] 1091045006697 lysine transporter; Provisional; Region: PRK10836 1091045006698 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1091045006699 dimer interface [polypeptide binding]; other site 1091045006700 catalytic triad [active] 1091045006701 peroxidatic and resolving cysteines [active] 1091045006702 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091045006703 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091045006704 active site 1091045006705 catalytic tetrad [active] 1091045006706 ACT domain; Region: ACT_6; pfam13740 1091045006707 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1091045006708 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1091045006709 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1091045006710 dimer interface [polypeptide binding]; other site 1091045006711 putative active site [active] 1091045006712 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1091045006713 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1091045006714 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1091045006715 putative substrate binding site [chemical binding]; other site 1091045006716 nucleotide binding site [chemical binding]; other site 1091045006717 nucleotide binding site [chemical binding]; other site 1091045006718 homodimer interface [polypeptide binding]; other site 1091045006719 ornithine carbamoyltransferase; Validated; Region: PRK02102 1091045006720 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1091045006721 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1091045006722 arginine deiminase; Provisional; Region: PRK01388 1091045006723 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1091045006724 Spore germination protein; Region: Spore_permease; cl17796 1091045006725 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1091045006726 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1091045006727 potential catalytic triad [active] 1091045006728 conserved cys residue [active] 1091045006729 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1091045006730 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1091045006731 MarR family; Region: MarR; pfam01047 1091045006732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091045006733 putative substrate translocation pore; other site 1091045006734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091045006735 GTP-binding protein YchF; Reviewed; Region: PRK09601 1091045006736 YchF GTPase; Region: YchF; cd01900 1091045006737 G1 box; other site 1091045006738 GTP/Mg2+ binding site [chemical binding]; other site 1091045006739 Switch I region; other site 1091045006740 G2 box; other site 1091045006741 Switch II region; other site 1091045006742 G3 box; other site 1091045006743 G4 box; other site 1091045006744 G5 box; other site 1091045006745 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1091045006746 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1091045006747 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1091045006748 active site 1091045006749 metal binding site [ion binding]; metal-binding site 1091045006750 RmuC family; Region: RmuC; pfam02646 1091045006751 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1091045006752 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1091045006753 potential frameshift: common BLAST hit: gi|295130139|ref|YP_003580802.1| phosphoesterase family protein 1091045006754 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1091045006755 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1091045006756 generic binding surface II; other site 1091045006757 generic binding surface I; other site 1091045006758 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1091045006759 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1091045006760 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1091045006761 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1091045006762 putative active site [active] 1091045006763 PhoH-like protein; Region: PhoH; pfam02562 1091045006764 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1091045006765 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1091045006766 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1091045006767 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1091045006768 catalytic residue [active] 1091045006769 putative FPP diphosphate binding site; other site 1091045006770 putative FPP binding hydrophobic cleft; other site 1091045006771 dimer interface [polypeptide binding]; other site 1091045006772 putative IPP diphosphate binding site; other site 1091045006773 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1091045006774 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1091045006775 catalytic residues [active] 1091045006776 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1091045006777 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1091045006778 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1091045006779 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1091045006780 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091045006781 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091045006782 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1091045006783 ligand binding site [chemical binding]; other site 1091045006784 active site 1091045006785 UGI interface [polypeptide binding]; other site 1091045006786 catalytic site [active] 1091045006787 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1091045006788 putative substrate binding site 2 [chemical binding]; other site 1091045006789 putative substrate binding site 1 [chemical binding]; other site 1091045006790 Na binding site 1 [ion binding]; other site 1091045006791 Na2 binding site [ion binding]; other site 1091045006792 potential frameshift: common BLAST hit: gi|50842042|ref|YP_055269.1| peptide methionine sulfoxide reductase 1091045006793 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091045006794 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091045006795 active site 1091045006796 catalytic tetrad [active] 1091045006797 Predicted membrane protein [Function unknown]; Region: COG1297 1091045006798 putative oligopeptide transporter, OPT family; Region: TIGR00733 1091045006799 Predicted membrane protein [Function unknown]; Region: COG2246 1091045006800 GtrA-like protein; Region: GtrA; pfam04138 1091045006801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091045006802 Coenzyme A binding pocket [chemical binding]; other site