-- dump date   	20140619_235505
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
246198000001	OsmC-like protein; Region: OsmC; pfam02566
246198000002	Predicted transcriptional regulator [Transcription]; Region: COG3655
246198000003	sequence-specific DNA binding site [nucleotide binding]; other site
246198000004	salt bridge; other site
246198000005	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198000006	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
246198000007	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198000008	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198000009	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198000010	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
246198000011	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198000012	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
246198000013	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
246198000014	N-terminal plug; other site
246198000015	ligand-binding site [chemical binding]; other site
246198000016	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
246198000017	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
246198000018	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
246198000019	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
246198000020	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
246198000021	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
246198000022	Peptidase family C69; Region: Peptidase_C69; cl17793
246198000023	Peptidase family M23; Region: Peptidase_M23; pfam01551
246198000024	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
246198000025	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
246198000026	lipoprotein signal peptidase; Provisional; Region: PRK14788
246198000027	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
246198000028	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
246198000029	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198000030	active site
246198000031	HIGH motif; other site
246198000032	nucleotide binding site [chemical binding]; other site
246198000033	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198000034	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198000035	active site
246198000036	KMSKS motif; other site
246198000037	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
246198000038	tRNA binding surface [nucleotide binding]; other site
246198000039	anticodon binding site; other site
246198000040	DKNYY family; Region: DKNYY; pfam13644
246198000041	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
246198000042	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
246198000043	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
246198000044	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
246198000045	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
246198000046	NodB motif; other site
246198000047	active site
246198000048	catalytic site [active]
246198000049	metal binding site [ion binding]; metal-binding site
246198000050	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
246198000051	4Fe-4S binding domain; Region: Fer4; cl02805
246198000052	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
246198000053	Peptidase C10 family; Region: Peptidase_C10; pfam01640
246198000054	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198000055	Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675
246198000056	Domain of unknown function (DUF389); Region: DUF389; pfam04087
246198000057	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
246198000058	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
246198000059	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
246198000060	active site
246198000061	catalytic residues [active]
246198000062	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
246198000063	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
246198000064	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
246198000065	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
246198000066	active site
246198000067	catalytic residues [active]
246198000068	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
246198000069	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
246198000070	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
246198000071	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
246198000072	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
246198000073	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
246198000074	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
246198000075	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
246198000076	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
246198000077	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
246198000078	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
246198000079	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
246198000080	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
246198000081	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
246198000082	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
246198000083	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
246198000084	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
246198000085	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
246198000086	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
246198000087	AAA domain; Region: AAA_21; pfam13304
246198000088	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
246198000089	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
246198000090	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
246198000091	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198000092	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198000093	DNA binding residues [nucleotide binding]
246198000094	Fic family protein [Function unknown]; Region: COG3177
246198000095	Fic/DOC family; Region: Fic; pfam02661
246198000096	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
246198000097	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
246198000098	active site
246198000099	substrate binding site [chemical binding]; other site
246198000100	Mg2+ binding site [ion binding]; other site
246198000101	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
246198000102	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
246198000103	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
246198000104	metal binding site [ion binding]; metal-binding site
246198000105	dimer interface [polypeptide binding]; other site
246198000106	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
246198000107	Transglycosylase; Region: Transgly; pfam00912
246198000108	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
246198000109	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
246198000110	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
246198000111	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
246198000112	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
246198000113	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
246198000114	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
246198000115	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
246198000116	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
246198000117	dimer interface [polypeptide binding]; other site
246198000118	active site
246198000119	glycine-pyridoxal phosphate binding site [chemical binding]; other site
246198000120	folate binding site [chemical binding]; other site
246198000121	Family of unknown function (DUF490); Region: DUF490; pfam04357
246198000122	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
246198000123	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
246198000124	lipoyl-biotinyl attachment site [posttranslational modification]; other site
246198000125	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
246198000126	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
246198000127	FMN-binding domain; Region: FMN_bind; cl01081
246198000128	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
246198000129	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
246198000130	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
246198000131	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
246198000132	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
246198000133	catalytic loop [active]
246198000134	iron binding site [ion binding]; other site
246198000135	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
246198000136	FAD binding pocket [chemical binding]; other site
246198000137	FAD binding motif [chemical binding]; other site
246198000138	phosphate binding motif [ion binding]; other site
246198000139	beta-alpha-beta structure motif; other site
246198000140	NAD binding pocket [chemical binding]; other site
246198000141	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
246198000142	Part of AAA domain; Region: AAA_19; pfam13245
246198000143	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
246198000144	active site
246198000145	catalytic site [active]
246198000146	substrate binding site [chemical binding]; other site
246198000147	Family description; Region: UvrD_C_2; pfam13538
246198000148	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
246198000149	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
246198000150	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
246198000151	Clp amino terminal domain; Region: Clp_N; pfam02861
246198000152	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000153	Walker A motif; other site
246198000154	ATP binding site [chemical binding]; other site
246198000155	Walker B motif; other site
246198000156	arginine finger; other site
246198000157	UvrB/uvrC motif; Region: UVR; pfam02151
246198000158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000159	Walker A motif; other site
246198000160	ATP binding site [chemical binding]; other site
246198000161	Walker B motif; other site
246198000162	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
246198000163	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
246198000164	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
246198000165	Pantoate-beta-alanine ligase; Region: PanC; cd00560
246198000166	pantoate--beta-alanine ligase; Region: panC; TIGR00018
246198000167	active site
246198000168	ATP-binding site [chemical binding]; other site
246198000169	pantoate-binding site; other site
246198000170	HXXH motif; other site
246198000171	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
246198000172	tetramerization interface [polypeptide binding]; other site
246198000173	active site
246198000174	A new structural DNA glycosylase; Region: AlkD_like; cl11434
246198000175	active site
246198000176	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
246198000177	hydrophobic ligand binding site; other site
246198000178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000179	Walker A motif; other site
246198000180	ATP binding site [chemical binding]; other site
246198000181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
246198000182	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
246198000183	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
246198000184	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
246198000185	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
246198000186	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
246198000187	Domain of unknown function (DUF4421); Region: DUF4421; pfam14391
246198000188	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
246198000189	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
246198000190	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
246198000191	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
246198000192	butyrate kinase; Provisional; Region: PRK03011
246198000193	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
246198000194	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198000195	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198000196	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198000197	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198000198	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000199	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000200	Transposase; Region: DDE_Tnp_ISL3; pfam01610
246198000201	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
246198000202	methionine sulfoxide reductase B; Provisional; Region: PRK00222
246198000203	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
246198000204	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
246198000205	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
246198000206	Ferritin-like domain; Region: Ferritin; pfam00210
246198000207	ferroxidase diiron center [ion binding]; other site
246198000208	Domain of unknown function DUF59; Region: DUF59; pfam01883
246198000209	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
246198000210	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
246198000211	Walker A motif; other site
246198000212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
246198000213	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
246198000214	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
246198000215	HutD; Region: HutD; cl01532
246198000216	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
246198000217	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
246198000218	active site triad [active]
246198000219	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
246198000220	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
246198000221	putative acyl-acceptor binding pocket; other site
246198000222	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
246198000223	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
246198000224	putative active site [active]
246198000225	putative metal binding site [ion binding]; other site
246198000226	dihydroorotase; Reviewed; Region: PRK09236
246198000227	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
246198000228	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
246198000229	active site
246198000230	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
246198000231	Septum formation initiator; Region: DivIC; cl17659
246198000232	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
246198000233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000234	Walker A motif; other site
246198000235	ATP binding site [chemical binding]; other site
246198000236	Walker B motif; other site
246198000237	arginine finger; other site
246198000238	MoxR-like ATPases [General function prediction only]; Region: COG0714
246198000239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000240	ATP binding site [chemical binding]; other site
246198000241	Walker A motif; other site
246198000242	Walker B motif; other site
246198000243	arginine finger; other site
246198000244	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
246198000245	Protein of unknown function DUF58; Region: DUF58; pfam01882
246198000246	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
246198000247	metal ion-dependent adhesion site (MIDAS); other site
246198000248	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
246198000249	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
246198000250	metal ion-dependent adhesion site (MIDAS); other site
246198000251	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
246198000252	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
246198000253	metal ion-dependent adhesion site (MIDAS); other site
246198000254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246198000255	binding surface
246198000256	TPR motif; other site
246198000257	Oxygen tolerance; Region: BatD; pfam13584
246198000258	Tetratricopeptide repeat; Region: TPR_16; pfam13432
246198000259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198000260	binding surface
246198000261	TPR motif; other site
246198000262	Src Homology 3 domain superfamily; Region: SH3; cl17036
246198000263	peptide ligand binding site [polypeptide binding]; other site
246198000264	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
246198000265	active site
246198000266	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
246198000267	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
246198000268	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
246198000269	Domain of unknown function (DUF2027); Region: DUF2027; pfam09640
246198000270	Smr domain; Region: Smr; cl02619
246198000271	NAD synthetase; Reviewed; Region: nadE; PRK02628
246198000272	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
246198000273	multimer interface [polypeptide binding]; other site
246198000274	active site
246198000275	catalytic triad [active]
246198000276	protein interface 1 [polypeptide binding]; other site
246198000277	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
246198000278	homodimer interface [polypeptide binding]; other site
246198000279	NAD binding pocket [chemical binding]; other site
246198000280	ATP binding pocket [chemical binding]; other site
246198000281	Mg binding site [ion binding]; other site
246198000282	active-site loop [active]
246198000283	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
246198000284	Malic enzyme, N-terminal domain; Region: malic; pfam00390
246198000285	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
246198000286	putative NAD(P) binding site [chemical binding]; other site
246198000287	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
246198000288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246198000289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246198000290	HD domain; Region: HD_4; pfam13328
246198000291	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
246198000292	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
246198000293	synthetase active site [active]
246198000294	NTP binding site [chemical binding]; other site
246198000295	metal binding site [ion binding]; metal-binding site
246198000296	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
246198000297	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
246198000298	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
246198000299	KilA-N domain; Region: KilA-N; pfam04383
246198000300	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198000301	Protein of unknown function, DUF481; Region: DUF481; cl01213
246198000302	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
246198000303	TIGR02646 family protein; Region: TIGR02646
246198000304	AAA domain; Region: AAA_21; pfam13304
246198000305	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198000306	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000307	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000308	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198000309	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000310	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
246198000312	Transposase; Region: DDE_Tnp_ISL3; pfam01610
246198000313	HNH endonuclease; Region: HNH_2; pfam13391
246198000314	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
246198000315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246198000316	NAD(P) binding site [chemical binding]; other site
246198000317	active site
246198000318	hypothetical protein; Provisional; Region: PRK12378
246198000319	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
246198000320	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
246198000321	putative tRNA-binding site [nucleotide binding]; other site
246198000322	B3/4 domain; Region: B3_4; pfam03483
246198000323	tRNA synthetase B5 domain; Region: B5; smart00874
246198000324	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
246198000325	dimer interface [polypeptide binding]; other site
246198000326	motif 1; other site
246198000327	motif 3; other site
246198000328	motif 2; other site
246198000329	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
246198000330	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
246198000331	active site
246198000332	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
246198000333	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
246198000334	substrate binding pocket [chemical binding]; other site
246198000335	chain length determination region; other site
246198000336	substrate-Mg2+ binding site; other site
246198000337	catalytic residues [active]
246198000338	aspartate-rich region 1; other site
246198000339	active site lid residues [active]
246198000340	aspartate-rich region 2; other site
246198000341	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
246198000342	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
246198000343	cytidylate kinase; Provisional; Region: cmk; PRK00023
246198000344	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
246198000345	active site
246198000346	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
246198000347	CMP-binding site; other site
246198000348	The sites determining sugar specificity; other site
246198000349	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
246198000350	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
246198000351	SurA N-terminal domain; Region: SurA_N_2; pfam13623
246198000352	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
246198000353	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
246198000354	Domain of unknown function DUF21; Region: DUF21; pfam01595
246198000355	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
246198000356	Transporter associated domain; Region: CorC_HlyC; smart01091
246198000357	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
246198000358	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
246198000359	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
246198000360	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
246198000361	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198000362	nucleotide binding region [chemical binding]; other site
246198000363	ATP-binding site [chemical binding]; other site
246198000364	SEC-C motif; Region: SEC-C; pfam02810
246198000365	Surface antigen; Region: Bac_surface_Ag; pfam01103
246198000366	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
246198000367	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
246198000368	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
246198000369	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
246198000370	ribosomal protein L33; Region: rpl33; CHL00104
246198000371	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
246198000372	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
246198000373	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
246198000374	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
246198000375	replicative DNA helicase; Region: DnaB; TIGR00665
246198000376	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
246198000377	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
246198000378	Walker A motif; other site
246198000379	ATP binding site [chemical binding]; other site
246198000380	Walker B motif; other site
246198000381	DNA binding loops [nucleotide binding]
246198000382	heat shock protein 90; Provisional; Region: PRK05218
246198000383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198000384	ATP binding site [chemical binding]; other site
246198000385	Mg2+ binding site [ion binding]; other site
246198000386	G-X-G motif; other site
246198000387	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
246198000388	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
246198000389	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
246198000390	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
246198000391	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
246198000392	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
246198000393	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
246198000394	catalytic site [active]
246198000395	putative active site [active]
246198000396	putative substrate binding site [chemical binding]; other site
246198000397	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
246198000398	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
246198000399	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
246198000400	putative RNA binding site [nucleotide binding]; other site
246198000401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198000402	S-adenosylmethionine binding site [chemical binding]; other site
246198000403	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
246198000404	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
246198000405	Ligand Binding Site [chemical binding]; other site
246198000406	TilS substrate C-terminal domain; Region: TilS_C; smart00977
246198000407	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
246198000408	MutS domain III; Region: MutS_III; pfam05192
246198000409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198000410	Walker A/P-loop; other site
246198000411	ATP binding site [chemical binding]; other site
246198000412	Q-loop/lid; other site
246198000413	ABC transporter signature motif; other site
246198000414	Walker B; other site
246198000415	D-loop; other site
246198000416	H-loop/switch region; other site
246198000417	Smr domain; Region: Smr; pfam01713
246198000418	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198000419	GLPGLI family protein; Region: GLPGLI; TIGR01200
246198000420	GLPGLI family protein; Region: GLPGLI; TIGR01200
246198000421	GLPGLI family protein; Region: GLPGLI; TIGR01200
246198000422	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
246198000423	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
246198000424	Walker A/P-loop; other site
246198000425	ATP binding site [chemical binding]; other site
246198000426	Q-loop/lid; other site
246198000427	ABC transporter signature motif; other site
246198000428	Walker B; other site
246198000429	D-loop; other site
246198000430	H-loop/switch region; other site
246198000431	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
246198000432	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246198000433	active site
246198000434	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
246198000435	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
246198000436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198000437	motif II; other site
246198000438	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
246198000439	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
246198000440	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198000441	hypothetical protein; Provisional; Region: PRK08201
246198000442	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
246198000443	metal binding site [ion binding]; metal-binding site
246198000444	putative dimer interface [polypeptide binding]; other site
246198000445	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
246198000446	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
246198000447	active site
246198000448	Zn binding site [ion binding]; other site
246198000449	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
246198000450	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
246198000451	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
246198000452	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
246198000453	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
246198000454	Substrate-binding site [chemical binding]; other site
246198000455	Substrate specificity [chemical binding]; other site
246198000456	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
246198000457	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
246198000458	Substrate-binding site [chemical binding]; other site
246198000459	Substrate specificity [chemical binding]; other site
246198000460	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
246198000461	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
246198000462	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246198000463	EcsC protein family; Region: EcsC; pfam12787
246198000464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246198000465	binding surface
246198000466	TPR motif; other site
246198000467	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246198000468	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
246198000469	homopentamer interface [polypeptide binding]; other site
246198000470	active site
246198000471	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
246198000472	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
246198000473	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
246198000474	lipoyl synthase; Provisional; Region: PRK05481
246198000475	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198000476	FeS/SAM binding site; other site
246198000477	FMN-binding domain; Region: FMN_bind; pfam04205
246198000478	4Fe-4S binding domain; Region: Fer4_5; pfam12801
246198000479	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
246198000480	oligomerization interface [polypeptide binding]; other site
246198000481	active site
246198000482	metal binding site [ion binding]; metal-binding site
246198000483	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
246198000484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198000485	motif II; other site
246198000486	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
246198000487	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
246198000488	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
246198000489	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
246198000490	active site
246198000491	putative DNA-binding cleft [nucleotide binding]; other site
246198000492	dimer interface [polypeptide binding]; other site
246198000493	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246198000494	IHF dimer interface [polypeptide binding]; other site
246198000495	IHF - DNA interface [nucleotide binding]; other site
246198000496	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246198000497	IHF dimer interface [polypeptide binding]; other site
246198000498	IHF - DNA interface [nucleotide binding]; other site
246198000499	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
246198000500	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
246198000501	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198000502	FeS/SAM binding site; other site
246198000503	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
246198000504	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
246198000505	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
246198000506	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
246198000507	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
246198000508	Ligand binding site; other site
246198000509	oligomer interface; other site
246198000510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198000511	S-adenosylmethionine binding site [chemical binding]; other site
246198000512	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
246198000513	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
246198000514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198000515	active site
246198000516	motif I; other site
246198000517	motif II; other site
246198000518	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246198000519	Active site serine [active]
246198000520	Maf-like protein; Region: Maf; pfam02545
246198000521	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
246198000522	active site
246198000523	dimer interface [polypeptide binding]; other site
246198000524	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
246198000525	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
246198000526	trimer interface [polypeptide binding]; other site
246198000527	putative metal binding site [ion binding]; other site
246198000528	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
246198000529	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
246198000530	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
246198000531	dimer interface [polypeptide binding]; other site
246198000532	motif 1; other site
246198000533	active site
246198000534	motif 2; other site
246198000535	motif 3; other site
246198000536	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
246198000537	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
246198000538	FAD binding domain; Region: FAD_binding_4; pfam01565
246198000539	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
246198000540	putative hydrolase; Provisional; Region: PRK02113
246198000541	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
246198000542	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246198000543	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246198000544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246198000545	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
246198000546	NAD(P) binding site [chemical binding]; other site
246198000547	active site
246198000548	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
246198000549	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246198000550	active site
246198000551	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
246198000552	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
246198000553	putative NAD(P) binding site [chemical binding]; other site
246198000554	homodimer interface [polypeptide binding]; other site
246198000555	homotetramer interface [polypeptide binding]; other site
246198000556	active site
246198000557	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
246198000558	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
246198000559	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
246198000560	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
246198000561	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
246198000562	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
246198000563	ABC-2 type transporter; Region: ABC2_membrane; cl17235
246198000564	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
246198000565	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
246198000566	HlyD family secretion protein; Region: HlyD_3; pfam13437
246198000567	Outer membrane efflux protein; Region: OEP; pfam02321
246198000568	Outer membrane efflux protein; Region: OEP; pfam02321
246198000569	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
246198000570	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
246198000571	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
246198000572	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
246198000573	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
246198000574	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
246198000575	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
246198000576	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
246198000577	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
246198000578	active site
246198000579	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
246198000580	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
246198000581	active site
246198000582	substrate binding site [chemical binding]; other site
246198000583	metal binding site [ion binding]; metal-binding site
246198000584	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
246198000585	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198000586	ATP binding site [chemical binding]; other site
246198000587	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
246198000588	AAA domain; Region: AAA_12; pfam13087
246198000589	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
246198000590	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
246198000591	SmpB-tmRNA interface; other site
246198000592	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
246198000593	Initiator Replication protein; Region: Rep_3; pfam01051
246198000594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246198000595	active site
246198000596	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
246198000597	DHH family; Region: DHH; pfam01368
246198000598	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
246198000599	transcription termination factor Rho; Provisional; Region: PRK12608
246198000600	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
246198000601	RNA binding site [nucleotide binding]; other site
246198000602	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
246198000603	multimer interface [polypeptide binding]; other site
246198000604	Walker A motif; other site
246198000605	ATP binding site [chemical binding]; other site
246198000606	Walker B motif; other site
246198000607	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
246198000608	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
246198000609	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
246198000610	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
246198000611	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
246198000612	RNA binding site [nucleotide binding]; other site
246198000613	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
246198000614	RNA binding site [nucleotide binding]; other site
246198000615	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
246198000616	RNA binding site [nucleotide binding]; other site
246198000617	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
246198000618	RNA binding site [nucleotide binding]; other site
246198000619	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
246198000620	RNA binding site [nucleotide binding]; other site
246198000621	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
246198000622	Lysozyme subfamily 2; Region: LYZ2; smart00047
246198000623	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
246198000624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
246198000625	Transposase; Region: DDE_Tnp_ISL3; pfam01610
246198000626	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198000627	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000628	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000629	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198000630	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
246198000631	Transposase; Region: DDE_Tnp_ISL3; pfam01610
246198000632	DNA repair protein RadA; Provisional; Region: PRK11823
246198000633	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
246198000634	Walker A motif/ATP binding site; other site
246198000635	ATP binding site [chemical binding]; other site
246198000636	Walker B motif; other site
246198000637	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
246198000638	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
246198000639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198000640	binding surface
246198000641	TPR motif; other site
246198000642	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
246198000643	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
246198000644	Surface antigen; Region: Bac_surface_Ag; pfam01103
246198000645	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
246198000646	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
246198000647	prolyl-tRNA synthetase; Provisional; Region: PRK08661
246198000648	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
246198000649	dimer interface [polypeptide binding]; other site
246198000650	motif 1; other site
246198000651	active site
246198000652	motif 2; other site
246198000653	motif 3; other site
246198000654	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
246198000655	anticodon binding site; other site
246198000656	zinc-binding site [ion binding]; other site
246198000657	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246198000658	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246198000659	ligand binding site [chemical binding]; other site
246198000660	Predicted membrane protein [Function unknown]; Region: COG2855
246198000661	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
246198000662	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
246198000663	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
246198000664	G1 box; other site
246198000665	GTP/Mg2+ binding site [chemical binding]; other site
246198000666	Switch I region; other site
246198000667	G2 box; other site
246198000668	G3 box; other site
246198000669	Switch II region; other site
246198000670	G4 box; other site
246198000671	G5 box; other site
246198000672	Nucleoside recognition; Region: Gate; pfam07670
246198000673	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
246198000674	Nucleoside recognition; Region: Gate; pfam07670
246198000675	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
246198000676	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
246198000677	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
246198000678	active site
246198000679	nucleophile elbow; other site
246198000680	ATP cone domain; Region: ATP-cone; pfam03477
246198000681	anaerobic ribonucleoside-triphosphate reductase; Region: RNR_anaer_Bdell; TIGR02827
246198000682	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
246198000683	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: RNR_activ_nrdG3; TIGR02826
246198000684	AAA domain; Region: AAA_14; pfam13173
246198000685	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
246198000686	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
246198000687	iron binding site [ion binding]; other site
246198000688	Rubrerythrin [Energy production and conversion]; Region: COG1592
246198000689	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
246198000690	binuclear metal center [ion binding]; other site
246198000691	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
246198000692	iron binding site [ion binding]; other site
246198000693	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
246198000694	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
246198000695	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
246198000696	putative active site [active]
246198000697	putative catalytic site [active]
246198000698	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
246198000699	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198000700	FeS/SAM binding site; other site
246198000701	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
246198000702	Pyruvate formate lyase 1; Region: PFL1; cd01678
246198000703	coenzyme A binding site [chemical binding]; other site
246198000704	active site
246198000705	catalytic residues [active]
246198000706	glycine loop; other site
246198000707	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198000708	Walker A/P-loop; other site
246198000709	ATP binding site [chemical binding]; other site
246198000710	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000711	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000712	helicase superfamily c-terminal domain; Region: HELICc; smart00490
246198000713	ATP-binding site [chemical binding]; other site
246198000714	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198000715	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
246198000716	active site
246198000717	DNA binding site [nucleotide binding]
246198000718	Int/Topo IB signature motif; other site
246198000719	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000720	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000721	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198000722	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198000723	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
246198000724	Int/Topo IB signature motif; other site
246198000725	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
246198000726	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
246198000727	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
246198000728	ORF6N domain; Region: ORF6N; pfam10543
246198000729	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
246198000730	HsdM N-terminal domain; Region: HsdM_N; pfam12161
246198000731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198000732	S-adenosylmethionine binding site [chemical binding]; other site
246198000733	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
246198000734	Uncharacterized conserved protein [Function unknown]; Region: COG1479
246198000735	Protein of unknown function DUF262; Region: DUF262; pfam03235
246198000736	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
246198000737	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
246198000738	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
246198000739	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198000740	ATP binding site [chemical binding]; other site
246198000741	putative Mg++ binding site [ion binding]; other site
246198000742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246198000743	non-specific DNA binding site [nucleotide binding]; other site
246198000744	salt bridge; other site
246198000745	sequence-specific DNA binding site [nucleotide binding]; other site
246198000746	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000747	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000748	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198000749	active site
246198000750	catalytic residues [active]
246198000751	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
246198000752	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
246198000753	Int/Topo IB signature motif; other site
246198000754	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198000755	active site
246198000756	DNA binding site [nucleotide binding]
246198000757	Int/Topo IB signature motif; other site
246198000758	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198000759	Walker A/P-loop; other site
246198000760	ATP binding site [chemical binding]; other site
246198000761	AAA ATPase domain; Region: AAA_15; pfam13175
246198000762	AAA domain; Region: AAA_14; pfam13173
246198000763	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
246198000764	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
246198000765	CHC2 zinc finger; Region: zf-CHC2; cl17510
246198000766	Toprim-like; Region: Toprim_2; pfam13155
246198000767	AAA domain; Region: AAA_25; pfam13481
246198000768	Protein of unknown function (DUF3853); Region: DUF3853; pfam12964
246198000769	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246198000770	non-specific DNA binding site [nucleotide binding]; other site
246198000771	salt bridge; other site
246198000772	sequence-specific DNA binding site [nucleotide binding]; other site
246198000773	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
246198000774	putative homodimer interface [polypeptide binding]; other site
246198000775	putative active site [active]
246198000776	catalytic site [active]
246198000777	DEAD-like helicases superfamily; Region: DEXDc; smart00487
246198000778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198000779	ATP binding site [chemical binding]; other site
246198000780	putative Mg++ binding site [ion binding]; other site
246198000781	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
246198000782	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198000783	nucleotide binding region [chemical binding]; other site
246198000784	ATP-binding site [chemical binding]; other site
246198000785	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
246198000786	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
246198000787	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
246198000788	multiple promoter invertase; Provisional; Region: mpi; PRK13413
246198000789	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
246198000790	catalytic residues [active]
246198000791	catalytic nucleophile [active]
246198000792	Presynaptic Site I dimer interface [polypeptide binding]; other site
246198000793	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
246198000794	Synaptic Flat tetramer interface [polypeptide binding]; other site
246198000795	Synaptic Site I dimer interface [polypeptide binding]; other site
246198000796	DNA binding site [nucleotide binding]
246198000797	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
246198000798	DNA-binding interface [nucleotide binding]; DNA binding site
246198000799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198000800	S-adenosylmethionine binding site [chemical binding]; other site
246198000801	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
246198000802	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
246198000803	active site
246198000804	catalytic residues [active]
246198000805	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000806	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000807	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
246198000808	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
246198000809	DNA polymerase III subunit beta; Validated; Region: PRK05643
246198000810	putative DNA binding surface [nucleotide binding]; other site
246198000811	dimer interface [polypeptide binding]; other site
246198000812	beta-clamp/translesion DNA polymerase binding surface; other site
246198000813	beta-clamp/clamp loader binding surface; other site
246198000814	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
246198000815	active site
246198000816	catalytic site [active]
246198000817	substrate binding site [chemical binding]; other site
246198000818	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
246198000819	Flavoprotein; Region: Flavoprotein; pfam02441
246198000820	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
246198000821	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
246198000822	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
246198000823	Walker A/P-loop; other site
246198000824	ATP binding site [chemical binding]; other site
246198000825	Q-loop/lid; other site
246198000826	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
246198000827	ABC transporter signature motif; other site
246198000828	Walker B; other site
246198000829	D-loop; other site
246198000830	H-loop/switch region; other site
246198000831	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
246198000832	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
246198000833	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
246198000834	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198000835	TPR motif; other site
246198000836	binding surface
246198000837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198000838	TPR motif; other site
246198000839	binding surface
246198000840	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
246198000841	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
246198000842	Uncharacterized conserved protein [Function unknown]; Region: COG2461
246198000843	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
246198000844	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
246198000845	methionine aminopeptidase; Provisional; Region: PRK12318
246198000846	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
246198000847	active site
246198000848	UGMP family protein; Validated; Region: PRK09604
246198000849	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
246198000850	Competence-damaged protein; Region: CinA; pfam02464
246198000851	Rubredoxin [Energy production and conversion]; Region: COG1773
246198000852	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
246198000853	iron binding site [ion binding]; other site
246198000854	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198000855	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198000856	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198000857	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
246198000858	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
246198000859	active site
246198000860	substrate binding site [chemical binding]; other site
246198000861	metal binding site [ion binding]; metal-binding site
246198000862	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
246198000863	G1 box; other site
246198000864	GTP/Mg2+ binding site [chemical binding]; other site
246198000865	Switch I region; other site
246198000866	G2 box; other site
246198000867	G3 box; other site
246198000868	Switch II region; other site
246198000869	G4 box; other site
246198000870	G5 box; other site
246198000871	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
246198000872	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198000873	ABC transporter; Region: ABC_tran_2; pfam12848
246198000874	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198000875	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198000876	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000877	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000878	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198000879	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000880	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
246198000882	Transposase; Region: DDE_Tnp_ISL3; pfam01610
246198000883	B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072
246198000884	B12 binding site [chemical binding]; other site
246198000885	heterodimer interface [polypeptide binding]; other site
246198000886	cobalt ligand [ion binding]; other site
246198000887	MutL protein; Region: MutL; pfam13941
246198000888	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245
246198000889	substrate binding site [chemical binding]; other site
246198000890	B12 cofactor binding site [chemical binding]; other site
246198000891	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
246198000892	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
246198000893	methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502
246198000894	Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314
246198000895	dimer interface [polypeptide binding]; other site
246198000896	active site
246198000897	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
246198000898	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
246198000899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198000900	Walker A/P-loop; other site
246198000901	ATP binding site [chemical binding]; other site
246198000902	Q-loop/lid; other site
246198000903	ABC transporter signature motif; other site
246198000904	D-loop; other site
246198000905	H-loop/switch region; other site
246198000906	fumarate hydratase; Provisional; Region: PRK06246
246198000907	Fumarase C-terminus; Region: Fumerase_C; cl00795
246198000908	Peptidase S46; Region: Peptidase_S46; pfam10459
246198000909	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
246198000910	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
246198000911	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
246198000912	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
246198000913	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
246198000914	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
246198000915	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
246198000916	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
246198000917	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
246198000918	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
246198000919	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
246198000920	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
246198000921	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
246198000922	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
246198000923	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
246198000924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
246198000925	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
246198000926	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
246198000927	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198000928	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
246198000929	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198000930	DNA binding residues [nucleotide binding]
246198000931	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
246198000932	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
246198000933	GAD-like domain; Region: GAD-like; pfam08887
246198000934	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
246198000935	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
246198000936	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
246198000937	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
246198000938	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
246198000939	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000940	Walker A motif; other site
246198000941	ATP binding site [chemical binding]; other site
246198000942	Walker B motif; other site
246198000943	arginine finger; other site
246198000944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198000945	Walker A motif; other site
246198000946	ATP binding site [chemical binding]; other site
246198000947	Walker B motif; other site
246198000948	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
246198000949	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
246198000950	PKD domain; Region: PKD; pfam00801
246198000951	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
246198000952	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
246198000953	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
246198000954	Tetratricopeptide repeat; Region: TPR_16; pfam13432
246198000955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198000956	TPR motif; other site
246198000957	binding surface
246198000958	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198000959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198000960	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
246198000961	Walker A/P-loop; other site
246198000962	ATP binding site [chemical binding]; other site
246198000963	Q-loop/lid; other site
246198000964	ABC transporter signature motif; other site
246198000965	Walker B; other site
246198000966	D-loop; other site
246198000967	H-loop/switch region; other site
246198000968	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246198000969	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198000970	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198000971	Walker A/P-loop; other site
246198000972	ATP binding site [chemical binding]; other site
246198000973	Q-loop/lid; other site
246198000974	ABC transporter signature motif; other site
246198000975	Walker B; other site
246198000976	D-loop; other site
246198000977	H-loop/switch region; other site
246198000978	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246198000979	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246198000980	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198000981	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198000982	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198000983	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198000984	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
246198000985	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246198000986	catalytic residues [active]
246198000987	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
246198000988	putative DNA binding site [nucleotide binding]; other site
246198000989	putative Zn2+ binding site [ion binding]; other site
246198000990	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
246198000991	Peptidase M15; Region: Peptidase_M15_3; cl01194
246198000992	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
246198000993	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198000994	HipA-like N-terminal domain; Region: HipA_N; pfam07805
246198000995	HipA-like C-terminal domain; Region: HipA_C; pfam07804
246198000996	HipA N-terminal domain; Region: couple_hipA; TIGR03071
246198000997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246198000998	non-specific DNA binding site [nucleotide binding]; other site
246198000999	salt bridge; other site
246198001000	sequence-specific DNA binding site [nucleotide binding]; other site
246198001001	RteC protein; Region: RteC; pfam09357
246198001002	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
246198001003	homotrimer interaction site [polypeptide binding]; other site
246198001004	putative active site [active]
246198001005	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
246198001006	active site
246198001007	Zn binding site [ion binding]; other site
246198001008	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
246198001009	AAA domain; Region: AAA_31; pfam13614
246198001010	P-loop; other site
246198001011	Magnesium ion binding site [ion binding]; other site
246198001012	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
246198001013	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
246198001014	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
246198001015	FMN-binding domain; Region: FMN_bind; pfam04205
246198001016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198001017	Response regulator receiver domain; Region: Response_reg; pfam00072
246198001018	active site
246198001019	phosphorylation site [posttranslational modification]
246198001020	intermolecular recognition site; other site
246198001021	dimerization interface [polypeptide binding]; other site
246198001022	LytTr DNA-binding domain; Region: LytTR; smart00850
246198001023	Histidine kinase; Region: His_kinase; pfam06580
246198001024	V-type ATP synthase subunit I; Validated; Region: PRK05771
246198001025	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
246198001026	AAA domain; Region: AAA_22; pfam13401
246198001027	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
246198001028	Walker A motif; other site
246198001029	ATP binding site [chemical binding]; other site
246198001030	Walker B motif; other site
246198001031	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
246198001032	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
246198001033	potential frameshift: common BLAST hit: gi|325279523|ref|YP_004252065.1| phage head morphogenesis protein, SPP1 gp7 family
246198001034	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
246198001035	Protein of unknown function (DUF935); Region: DUF935; pfam06074
246198001036	Protein of unknown function (DUF1320); Region: DUF1320; cl01818
246198001037	Terminase-like family; Region: Terminase_6; pfam03237
246198001038	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
246198001039	DNA-binding interface [nucleotide binding]; DNA binding site
246198001040	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
246198001041	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
246198001042	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
246198001043	amidase catalytic site [active]
246198001044	Zn binding residues [ion binding]; other site
246198001045	substrate binding site [chemical binding]; other site
246198001046	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
246198001047	major vault protein; Provisional; Region: PTZ00491
246198001048	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
246198001049	dimerization interface [polypeptide binding]; other site
246198001050	active site
246198001051	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
246198001052	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
246198001053	aminotransferase AlaT; Validated; Region: PRK09265
246198001054	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
246198001055	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198001056	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
246198001057	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
246198001058	N-terminal plug; other site
246198001059	ligand-binding site [chemical binding]; other site
246198001060	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
246198001061	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
246198001062	FtsH Extracellular; Region: FtsH_ext; pfam06480
246198001063	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
246198001064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198001065	Walker A motif; other site
246198001066	ATP binding site [chemical binding]; other site
246198001067	Walker B motif; other site
246198001068	arginine finger; other site
246198001069	Peptidase family M41; Region: Peptidase_M41; pfam01434
246198001070	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
246198001071	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
246198001072	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
246198001073	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
246198001074	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
246198001075	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
246198001076	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
246198001077	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
246198001078	Cl binding site [ion binding]; other site
246198001079	oligomer interface [polypeptide binding]; other site
246198001080	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
246198001081	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
246198001082	metal binding site [ion binding]; metal-binding site
246198001083	dimer interface [polypeptide binding]; other site
246198001084	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
246198001085	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
246198001086	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
246198001087	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
246198001088	GAF domain; Region: GAF_2; pfam13185
246198001089	ribosome recycling factor; Reviewed; Region: frr; PRK00083
246198001090	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
246198001091	hinge region; other site
246198001092	GTPase RsgA; Reviewed; Region: PRK00098
246198001093	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
246198001094	RNA binding site [nucleotide binding]; other site
246198001095	homodimer interface [polypeptide binding]; other site
246198001096	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
246198001097	GTPase/Zn-binding domain interface [polypeptide binding]; other site
246198001098	GTP/Mg2+ binding site [chemical binding]; other site
246198001099	G4 box; other site
246198001100	G5 box; other site
246198001101	G1 box; other site
246198001102	Switch I region; other site
246198001103	G2 box; other site
246198001104	G3 box; other site
246198001105	Switch II region; other site
246198001106	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
246198001107	active site
246198001108	catalytic triad [active]
246198001109	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
246198001110	metal binding site 2 [ion binding]; metal-binding site
246198001111	putative DNA binding helix; other site
246198001112	metal binding site 1 [ion binding]; metal-binding site
246198001113	dimer interface [polypeptide binding]; other site
246198001114	structural Zn2+ binding site [ion binding]; other site
246198001115	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
246198001116	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
246198001117	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246198001118	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
246198001119	active site
246198001120	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
246198001121	dimer interface [polypeptide binding]; other site
246198001122	substrate binding site [chemical binding]; other site
246198001123	catalytic residues [active]
246198001124	RmuC family; Region: RmuC; pfam02646
246198001125	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
246198001126	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
246198001127	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
246198001128	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
246198001129	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198001130	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198001131	active site
246198001132	catalytic residues [active]
246198001133	catalytic residues [active]
246198001134	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
246198001135	Interdomain contacts; other site
246198001136	Cytokine receptor motif; other site
246198001137	CopC domain; Region: CopC; cl01012
246198001138	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198001139	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
246198001140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198001141	ATP binding site [chemical binding]; other site
246198001142	Mg2+ binding site [ion binding]; other site
246198001143	G-X-G motif; other site
246198001144	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
246198001145	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
246198001146	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
246198001147	dimer interface [polypeptide binding]; other site
246198001148	active site
246198001149	CoA binding pocket [chemical binding]; other site
246198001150	GTPase Era; Reviewed; Region: era; PRK00089
246198001151	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
246198001152	G1 box; other site
246198001153	GTP/Mg2+ binding site [chemical binding]; other site
246198001154	Switch I region; other site
246198001155	G2 box; other site
246198001156	Switch II region; other site
246198001157	G3 box; other site
246198001158	G4 box; other site
246198001159	G5 box; other site
246198001160	KH domain; Region: KH_2; pfam07650
246198001161	GTP-binding protein Der; Reviewed; Region: PRK00093
246198001162	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
246198001163	G1 box; other site
246198001164	GTP/Mg2+ binding site [chemical binding]; other site
246198001165	Switch I region; other site
246198001166	G2 box; other site
246198001167	Switch II region; other site
246198001168	G3 box; other site
246198001169	G4 box; other site
246198001170	G5 box; other site
246198001171	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
246198001172	G1 box; other site
246198001173	GTP/Mg2+ binding site [chemical binding]; other site
246198001174	Switch I region; other site
246198001175	G2 box; other site
246198001176	G3 box; other site
246198001177	Switch II region; other site
246198001178	G4 box; other site
246198001179	G5 box; other site
246198001180	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
246198001181	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
246198001182	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
246198001183	Walker A/P-loop; other site
246198001184	ATP binding site [chemical binding]; other site
246198001185	Q-loop/lid; other site
246198001186	ABC transporter signature motif; other site
246198001187	Walker B; other site
246198001188	D-loop; other site
246198001189	H-loop/switch region; other site
246198001190	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
246198001191	Permease; Region: Permease; pfam02405
246198001192	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
246198001193	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
246198001194	Walker A/P-loop; other site
246198001195	ATP binding site [chemical binding]; other site
246198001196	Q-loop/lid; other site
246198001197	ABC transporter signature motif; other site
246198001198	Walker B; other site
246198001199	D-loop; other site
246198001200	H-loop/switch region; other site
246198001201	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
246198001202	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198001203	Walker A/P-loop; other site
246198001204	ATP binding site [chemical binding]; other site
246198001205	Q-loop/lid; other site
246198001206	ABC transporter signature motif; other site
246198001207	Walker B; other site
246198001208	D-loop; other site
246198001209	H-loop/switch region; other site
246198001210	ABC transporter; Region: ABC_tran_2; pfam12848
246198001211	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198001212	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198001213	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198001214	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
246198001215	IHF dimer interface [polypeptide binding]; other site
246198001216	IHF - DNA interface [nucleotide binding]; other site
246198001217	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246198001218	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246198001219	ligand binding site [chemical binding]; other site
246198001220	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
246198001221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198001222	ATP binding site [chemical binding]; other site
246198001223	Mg2+ binding site [ion binding]; other site
246198001224	G-X-G motif; other site
246198001225	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
246198001226	ATP binding site [chemical binding]; other site
246198001227	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
246198001228	OstA-like protein; Region: OstA_2; pfam13100
246198001229	OstA-like protein; Region: OstA; cl00844
246198001230	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
246198001231	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
246198001232	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
246198001233	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
246198001234	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
246198001235	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
246198001236	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
246198001237	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
246198001238	active site
246198001239	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
246198001240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198001241	ATP binding site [chemical binding]; other site
246198001242	putative Mg++ binding site [ion binding]; other site
246198001243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198001244	nucleotide binding region [chemical binding]; other site
246198001245	ATP-binding site [chemical binding]; other site
246198001246	RQC domain; Region: RQC; pfam09382
246198001247	HRDC domain; Region: HRDC; pfam00570
246198001248	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
246198001249	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
246198001250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198001251	Walker A motif; other site
246198001252	ATP binding site [chemical binding]; other site
246198001253	Walker B motif; other site
246198001254	arginine finger; other site
246198001255	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
246198001256	Clp protease; Region: CLP_protease; pfam00574
246198001257	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
246198001258	oligomer interface [polypeptide binding]; other site
246198001259	active site residues [active]
246198001260	trigger factor; Region: tig; TIGR00115
246198001261	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
246198001262	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
246198001263	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
246198001264	Potassium binding sites [ion binding]; other site
246198001265	Cesium cation binding sites [ion binding]; other site
246198001266	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
246198001267	active site triad [active]
246198001268	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
246198001269	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
246198001270	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
246198001271	CAP-like domain; other site
246198001272	active site
246198001273	primary dimer interface [polypeptide binding]; other site
246198001274	glycyl-tRNA synthetase; Provisional; Region: PRK04173
246198001275	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
246198001276	motif 1; other site
246198001277	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
246198001278	active site
246198001279	motif 2; other site
246198001280	motif 3; other site
246198001281	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
246198001282	anticodon binding site; other site
246198001283	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
246198001284	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
246198001285	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
246198001286	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
246198001287	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
246198001288	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
246198001289	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
246198001290	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
246198001291	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
246198001292	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
246198001293	P-loop; other site
246198001294	Magnesium ion binding site [ion binding]; other site
246198001295	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
246198001296	Magnesium ion binding site [ion binding]; other site
246198001297	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
246198001298	ParB-like nuclease domain; Region: ParBc; pfam02195
246198001299	KorB domain; Region: KorB; pfam08535
246198001300	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
246198001301	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246198001302	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246198001303	catalytic residue [active]
246198001304	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
246198001305	HD domain; Region: HD_4; pfam13328
246198001306	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
246198001307	synthetase active site [active]
246198001308	NTP binding site [chemical binding]; other site
246198001309	metal binding site [ion binding]; metal-binding site
246198001310	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
246198001311	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
246198001312	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
246198001313	putative transporter; Provisional; Region: PRK11660
246198001314	Sulfate transporter family; Region: Sulfate_transp; pfam00916
246198001315	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
246198001316	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
246198001317	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
246198001318	non-heme iron binding site [ion binding]; other site
246198001319	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
246198001320	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198001321	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
246198001322	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198001323	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198001324	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
246198001325	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
246198001326	putative ligand binding site [chemical binding]; other site
246198001327	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
246198001328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246198001329	dimer interface [polypeptide binding]; other site
246198001330	phosphorylation site [posttranslational modification]
246198001331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198001332	ATP binding site [chemical binding]; other site
246198001333	Mg2+ binding site [ion binding]; other site
246198001334	G-X-G motif; other site
246198001335	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
246198001336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198001337	active site
246198001338	phosphorylation site [posttranslational modification]
246198001339	intermolecular recognition site; other site
246198001340	dimerization interface [polypeptide binding]; other site
246198001341	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
246198001342	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198001343	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198001344	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
246198001345	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
246198001346	substrate binding [chemical binding]; other site
246198001347	active site
246198001348	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
246198001349	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
246198001350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246198001351	putative substrate translocation pore; other site
246198001352	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
246198001353	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
246198001354	putative substrate binding site [chemical binding]; other site
246198001355	putative ATP binding site [chemical binding]; other site
246198001356	flavoprotein, HI0933 family; Region: TIGR00275
246198001357	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
246198001358	4-alpha-glucanotransferase; Region: PLN02950
246198001359	Starch binding domain; Region: CBM_2; smart01065
246198001360	starch-binding site 2 [chemical binding]; other site
246198001361	starch-binding site 1 [chemical binding]; other site
246198001362	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
246198001363	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
246198001364	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
246198001365	pullulanase, type I; Region: pulA_typeI; TIGR02104
246198001366	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
246198001367	Ca binding site [ion binding]; other site
246198001368	active site
246198001369	catalytic site [active]
246198001370	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
246198001371	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
246198001372	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
246198001373	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
246198001374	Ca binding site [ion binding]; other site
246198001375	active site
246198001376	homodimer interface [polypeptide binding]; other site
246198001377	catalytic site [active]
246198001378	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
246198001379	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
246198001380	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
246198001381	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
246198001382	Glycoprotease family; Region: Peptidase_M22; pfam00814
246198001383	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
246198001384	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
246198001385	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
246198001386	hinge; other site
246198001387	active site
246198001388	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
246198001389	RimM N-terminal domain; Region: RimM; pfam01782
246198001390	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
246198001391	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
246198001392	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
246198001393	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
246198001394	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
246198001395	RIP metalloprotease RseP; Region: TIGR00054
246198001396	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
246198001397	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
246198001398	putative substrate binding region [chemical binding]; other site
246198001399	LicD family; Region: LicD; cl01378
246198001400	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
246198001401	substrate binding site; other site
246198001402	dimer interface; other site
246198001403	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
246198001404	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246198001405	NAD(P) binding site [chemical binding]; other site
246198001406	active site
246198001407	putative pectinesterase; Region: PLN02432; cl01911
246198001408	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
246198001409	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198001410	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
246198001411	homotrimer interaction site [polypeptide binding]; other site
246198001412	zinc binding site [ion binding]; other site
246198001413	CDP-binding sites; other site
246198001414	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
246198001415	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
246198001416	active site
246198001417	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
246198001418	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
246198001419	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
246198001420	translation elongation factor Ts; Region: tsf; TIGR00116
246198001421	Elongation factor TS; Region: EF_TS; pfam00889
246198001422	Elongation factor TS; Region: EF_TS; pfam00889
246198001423	Elongation factor TS; Region: EF_TS; pfam00889
246198001424	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
246198001425	rRNA interaction site [nucleotide binding]; other site
246198001426	S8 interaction site; other site
246198001427	putative laminin-1 binding site; other site
246198001428	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
246198001429	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
246198001430	23S rRNA interface [nucleotide binding]; other site
246198001431	L3 interface [polypeptide binding]; other site
246198001432	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
246198001433	SIR2-like domain; Region: SIR2_2; pfam13289
246198001434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198001435	TPR motif; other site
246198001436	binding surface
246198001437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246198001438	TPR motif; other site
246198001439	binding surface
246198001440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198001441	TPR motif; other site
246198001442	binding surface
246198001443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246198001444	Major Facilitator Superfamily; Region: MFS_1; pfam07690
246198001445	putative substrate translocation pore; other site
246198001446	Transcriptional regulators [Transcription]; Region: PurR; COG1609
246198001447	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
246198001448	DNA binding site [nucleotide binding]
246198001449	domain linker motif; other site
246198001450	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
246198001451	dimerization interface [polypeptide binding]; other site
246198001452	ligand binding site [chemical binding]; other site
246198001453	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
246198001454	starch binding outer membrane protein SusD; Region: SusD; cd08977
246198001455	SusD family; Region: SusD; pfam07980
246198001456	SusE outer membrane protein; Region: SusE; pfam14292
246198001457	carbohydrate-binding modules Eb and Fb from SusE and SusF, respectively, and similar CBMs; Region: CBM-Eb_CBM-Fb; cd12965
246198001458	starch binding site [chemical binding]; other site
246198001459	carbohydrate-binding modules Ec and Fc from SusE and SusF, respectively, and similar CBMs; Region: CBM-Ec_CBM-Fc; cd12966
246198001460	starch binding site [chemical binding]; other site
246198001461	starch-binding loop; other site
246198001462	Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967
246198001463	starch binding site [chemical binding]; other site
246198001464	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956
246198001465	starch binding site [chemical binding]; other site
246198001466	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
246198001467	active site
246198001468	Ca binding site [ion binding]; other site
246198001469	catalytic site [active]
246198001470	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
246198001471	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
246198001472	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
246198001473	active site
246198001474	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
246198001475	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198001476	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198001477	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
246198001478	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246198001479	catalytic residues [active]
246198001480	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
246198001481	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246198001482	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198001483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198001484	Walker A/P-loop; other site
246198001485	ATP binding site [chemical binding]; other site
246198001486	Q-loop/lid; other site
246198001487	ABC transporter signature motif; other site
246198001488	Walker B; other site
246198001489	D-loop; other site
246198001490	H-loop/switch region; other site
246198001491	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
246198001492	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
246198001493	DJ-1 family protein; Region: not_thiJ; TIGR01383
246198001494	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
246198001495	conserved cys residue [active]
246198001496	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
246198001497	substrate binding site; other site
246198001498	dimer interface; other site
246198001499	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
246198001500	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
246198001501	generic binding surface II; other site
246198001502	ssDNA binding site; other site
246198001503	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198001504	ATP binding site [chemical binding]; other site
246198001505	putative Mg++ binding site [ion binding]; other site
246198001506	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198001507	nucleotide binding region [chemical binding]; other site
246198001508	ATP-binding site [chemical binding]; other site
246198001509	GLPGLI family protein; Region: GLPGLI; TIGR01200
246198001510	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198001511	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
246198001512	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
246198001513	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
246198001514	catalytic triad [active]
246198001515	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
246198001516	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
246198001517	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
246198001518	active site
246198001519	homodimer interface [polypeptide binding]; other site
246198001520	homotetramer interface [polypeptide binding]; other site
246198001521	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
246198001522	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
246198001523	Aspartase; Region: Aspartase; cd01357
246198001524	active sites [active]
246198001525	tetramer interface [polypeptide binding]; other site
246198001526	AAA domain; Region: AAA_14; pfam13173
246198001527	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
246198001528	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
246198001529	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
246198001530	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
246198001531	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
246198001532	hypothetical protein; Provisional; Region: PRK10649
246198001533	Sulfatase; Region: Sulfatase; cl17466
246198001534	Acyltransferase family; Region: Acyl_transf_3; pfam01757
246198001535	Acyltransferase family; Region: Acyl_transf_3; pfam01757
246198001536	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
246198001537	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
246198001538	Predicted membrane protein [Function unknown]; Region: COG2246
246198001539	GtrA-like protein; Region: GtrA; pfam04138
246198001540	Polo kinase kinase; Region: PKK; pfam12474
246198001541	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246198001542	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246198001543	active site
246198001544	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
246198001545	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
246198001546	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
246198001547	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
246198001548	active site
246198001549	(T/H)XGH motif; other site
246198001550	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
246198001551	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
246198001552	catalytic site [active]
246198001553	G-X2-G-X-G-K; other site
246198001554	hypothetical protein; Provisional; Region: PRK11820
246198001555	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
246198001556	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
246198001557	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
246198001558	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
246198001559	dimerization interface [polypeptide binding]; other site
246198001560	ATP binding site [chemical binding]; other site
246198001561	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
246198001562	dimerization interface [polypeptide binding]; other site
246198001563	ATP binding site [chemical binding]; other site
246198001564	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
246198001565	putative active site [active]
246198001566	catalytic triad [active]
246198001567	Chromate transporter; Region: Chromate_transp; pfam02417
246198001568	Chromate transporter; Region: Chromate_transp; pfam02417
246198001569	PIF1-like helicase; Region: PIF1; pfam05970
246198001570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198001571	Walker A motif; other site
246198001572	ATP binding site [chemical binding]; other site
246198001573	Walker B motif; other site
246198001574	Family description; Region: UvrD_C_2; pfam13538
246198001575	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
246198001576	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
246198001577	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
246198001578	metal-binding site
246198001579	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246198001580	ligand binding site [chemical binding]; other site
246198001581	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198001582	active site
246198001583	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
246198001584	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
246198001585	active site
246198001586	substrate-binding site [chemical binding]; other site
246198001587	metal-binding site [ion binding]
246198001588	ATP binding site [chemical binding]; other site
246198001589	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198001590	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198001591	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
246198001592	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
246198001593	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
246198001594	cell division protein FtsZ; Validated; Region: PRK09330
246198001595	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
246198001596	nucleotide binding site [chemical binding]; other site
246198001597	SulA interaction site; other site
246198001598	cell division protein FtsA; Region: ftsA; TIGR01174
246198001599	Cell division protein FtsA; Region: FtsA; smart00842
246198001600	Cell division protein FtsA; Region: FtsA; pfam14450
246198001601	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
246198001602	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
246198001603	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246198001604	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246198001605	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
246198001606	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
246198001607	homodimer interface [polypeptide binding]; other site
246198001608	active site
246198001609	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
246198001610	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
246198001611	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246198001612	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246198001613	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
246198001614	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
246198001615	Mg++ binding site [ion binding]; other site
246198001616	putative catalytic motif [active]
246198001617	putative substrate binding site [chemical binding]; other site
246198001618	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
246198001619	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
246198001620	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246198001621	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246198001622	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
246198001623	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
246198001624	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
246198001625	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
246198001626	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
246198001627	MraW methylase family; Region: Methyltransf_5; cl17771
246198001628	cell division protein MraZ; Reviewed; Region: PRK00326
246198001629	MraZ protein; Region: MraZ; pfam02381
246198001630	MraZ protein; Region: MraZ; pfam02381
246198001631	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
246198001632	putative acyl-acceptor binding pocket; other site
246198001633	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
246198001634	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
246198001635	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
246198001636	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
246198001637	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198001638	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
246198001639	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198001640	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198001641	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198001642	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198001643	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198001644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198001645	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
246198001646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198001647	ATP binding site [chemical binding]; other site
246198001648	Mg2+ binding site [ion binding]; other site
246198001649	G-X-G motif; other site
246198001650	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
246198001651	anchoring element; other site
246198001652	dimer interface [polypeptide binding]; other site
246198001653	ATP binding site [chemical binding]; other site
246198001654	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
246198001655	active site
246198001656	metal binding site [ion binding]; metal-binding site
246198001657	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
246198001658	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
246198001659	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
246198001660	Recombination protein O N terminal; Region: RecO_N; pfam11967
246198001661	Recombination protein O C terminal; Region: RecO_C; pfam02565
246198001662	NigD-like protein; Region: NigD; pfam12667
246198001663	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
246198001664	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198001665	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198001666	DNA binding residues [nucleotide binding]
246198001667	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
246198001668	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
246198001669	ligand binding site [chemical binding]; other site
246198001670	active site
246198001671	UGI interface [polypeptide binding]; other site
246198001672	catalytic site [active]
246198001673	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
246198001674	ligand binding site [chemical binding]; other site
246198001675	active site
246198001676	UGI interface [polypeptide binding]; other site
246198001677	catalytic site [active]
246198001678	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
246198001679	phosphoglyceromutase; Provisional; Region: PRK05434
246198001680	Nucleoside recognition; Region: Gate; pfam07670
246198001681	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
246198001682	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
246198001683	active site
246198001684	catalytic motif [active]
246198001685	Zn binding site [ion binding]; other site
246198001686	Right handed beta helix region; Region: Beta_helix; pfam13229
246198001687	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198001688	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
246198001689	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
246198001690	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
246198001691	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
246198001692	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
246198001693	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
246198001694	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
246198001695	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
246198001696	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
246198001697	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
246198001698	putative homodimer interface [polypeptide binding]; other site
246198001699	putative active site pocket [active]
246198001700	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
246198001701	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
246198001702	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
246198001703	Leucine rich repeat; Region: LRR_8; pfam13855
246198001704	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198001705	active site
246198001706	catalytic residues [active]
246198001707	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198001708	catalytic residues [active]
246198001709	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198001710	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198001711	starch binding outer membrane protein SusD; Region: SusD; cl17845
246198001712	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
246198001713	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198001714	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
246198001715	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
246198001716	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198001717	Predicted transcriptional regulator [Transcription]; Region: COG2378
246198001718	WYL domain; Region: WYL; pfam13280
246198001719	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
246198001720	RNA/DNA hybrid binding site [nucleotide binding]; other site
246198001721	active site
246198001722	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
246198001723	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
246198001724	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246198001725	catalytic residue [active]
246198001726	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
246198001727	FeS assembly protein SufD; Region: sufD; TIGR01981
246198001728	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
246198001729	FeS assembly ATPase SufC; Region: sufC; TIGR01978
246198001730	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
246198001731	Walker A/P-loop; other site
246198001732	ATP binding site [chemical binding]; other site
246198001733	Q-loop/lid; other site
246198001734	ABC transporter signature motif; other site
246198001735	Walker B; other site
246198001736	D-loop; other site
246198001737	H-loop/switch region; other site
246198001738	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
246198001739	putative ABC transporter; Region: ycf24; CHL00085
246198001740	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
246198001741	Translation-initiation factor 2; Region: IF-2; pfam11987
246198001742	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
246198001743	transcription termination factor NusA; Region: NusA; TIGR01953
246198001744	NusA N-terminal domain; Region: NusA_N; pfam08529
246198001745	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
246198001746	RNA binding site [nucleotide binding]; other site
246198001747	homodimer interface [polypeptide binding]; other site
246198001748	NusA-like KH domain; Region: KH_5; pfam13184
246198001749	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
246198001750	G-X-X-G motif; other site
246198001751	hypothetical protein; Validated; Region: PRK02001
246198001752	Sm1 motif; other site
246198001753	RNA binding site [nucleotide binding]; other site
246198001754	plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517
246198001755	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
246198001756	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
246198001757	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
246198001758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198001759	motif II; other site
246198001760	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
246198001761	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
246198001762	recA bacterial DNA recombination protein; Region: RecA; cl17211
246198001763	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
246198001764	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198001765	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
246198001766	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
246198001767	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
246198001768	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
246198001769	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
246198001770	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
246198001771	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
246198001772	nudix motif; other site
246198001773	Outer membrane protein Omp28; Region: Omp28; pfam11551
246198001774	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
246198001775	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246198001776	catalytic residues [active]
246198001777	Peptidase C10 family; Region: Peptidase_C10; pfam01640
246198001778	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
246198001779	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
246198001780	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
246198001781	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
246198001782	TPP-binding site; other site
246198001783	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
246198001784	PYR/PP interface [polypeptide binding]; other site
246198001785	dimer interface [polypeptide binding]; other site
246198001786	TPP binding site [chemical binding]; other site
246198001787	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
246198001788	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
246198001789	TrkA-N domain; Region: TrkA_N; pfam02254
246198001790	TrkA-C domain; Region: TrkA_C; pfam02080
246198001791	TrkA-N domain; Region: TrkA_N; pfam02254
246198001792	TrkA-C domain; Region: TrkA_C; pfam02080
246198001793	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
246198001794	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
246198001795	P-loop containing region of AAA domain; Region: AAA_29; cl17516
246198001796	AAA domain; Region: AAA_21; pfam13304
246198001797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198001798	ABC transporter signature motif; other site
246198001799	Walker B; other site
246198001800	D-loop; other site
246198001801	H-loop/switch region; other site
246198001802	Ribosome-binding factor A; Region: RBFA; pfam02033
246198001803	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
246198001804	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
246198001805	FtsX-like permease family; Region: FtsX; pfam02687
246198001806	NigD-like protein; Region: NigD; pfam12667
246198001807	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
246198001808	putative acyl-acceptor binding pocket; other site
246198001809	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
246198001810	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
246198001811	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
246198001812	ATP-grasp domain; Region: ATP-grasp_4; cl17255
246198001813	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
246198001814	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246198001815	RNA binding surface [nucleotide binding]; other site
246198001816	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246198001817	active site
246198001818	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
246198001819	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
246198001820	elongation factor P; Validated; Region: PRK00529
246198001821	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
246198001822	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
246198001823	RNA binding site [nucleotide binding]; other site
246198001824	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
246198001825	RNA binding site [nucleotide binding]; other site
246198001826	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
246198001827	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246198001828	active site
246198001829	hypothetical protein; Reviewed; Region: PRK00024
246198001830	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
246198001831	MPN+ (JAMM) motif; other site
246198001832	Zinc-binding site [ion binding]; other site
246198001833	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198001834	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
246198001835	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198001836	DNA binding residues [nucleotide binding]
246198001837	arginine decarboxylase; Provisional; Region: PRK05354
246198001838	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
246198001839	dimer interface [polypeptide binding]; other site
246198001840	active site
246198001841	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
246198001842	catalytic residues [active]
246198001843	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
246198001844	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
246198001845	Shikimate kinase; Region: SKI; pfam01202
246198001846	ADP binding site [chemical binding]; other site
246198001847	magnesium binding site [ion binding]; other site
246198001848	putative shikimate binding site; other site
246198001849	DNA topoisomerase I; Provisional; Region: PRK08780
246198001850	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
246198001851	active site
246198001852	interdomain interaction site; other site
246198001853	putative metal-binding site [ion binding]; other site
246198001854	nucleotide binding site [chemical binding]; other site
246198001855	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
246198001856	domain I; other site
246198001857	DNA binding groove [nucleotide binding]
246198001858	phosphate binding site [ion binding]; other site
246198001859	domain II; other site
246198001860	domain III; other site
246198001861	nucleotide binding site [chemical binding]; other site
246198001862	catalytic site [active]
246198001863	domain IV; other site
246198001864	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
246198001865	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
246198001866	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
246198001867	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
246198001868	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
246198001869	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198001870	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198001871	DNA binding residues [nucleotide binding]
246198001872	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
246198001873	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
246198001874	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
246198001875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198001876	Walker A motif; other site
246198001877	ATP binding site [chemical binding]; other site
246198001878	Walker B motif; other site
246198001879	arginine finger; other site
246198001880	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
246198001881	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
246198001882	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
246198001883	FMN binding site [chemical binding]; other site
246198001884	active site
246198001885	catalytic residues [active]
246198001886	substrate binding site [chemical binding]; other site
246198001887	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
246198001888	Leucine rich repeat; Region: LRR_8; pfam13855
246198001889	Leucine-rich repeats; other site
246198001890	Substrate binding site [chemical binding]; other site
246198001891	Leucine rich repeat; Region: LRR_8; pfam13855
246198001892	Uncharacterized conserved protein [Function unknown]; Region: COG1284
246198001893	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
246198001894	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
246198001895	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
246198001896	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
246198001897	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
246198001898	Soluble P-type ATPase [General function prediction only]; Region: COG4087
246198001899	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
246198001900	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
246198001901	archaeal exosome-like complex exonuclease 1; Region: ECX1; TIGR02065
246198001902	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
246198001903	RNase E interface [polypeptide binding]; other site
246198001904	trimer interface [polypeptide binding]; other site
246198001905	active site
246198001906	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
246198001907	putative nucleic acid binding region [nucleotide binding]; other site
246198001908	G-X-X-G motif; other site
246198001909	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
246198001910	RNA binding site [nucleotide binding]; other site
246198001911	domain interface; other site
246198001912	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
246198001913	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
246198001914	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246198001915	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246198001916	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
246198001917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198001918	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
246198001919	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198001920	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
246198001921	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198001922	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
246198001923	CAAX protease self-immunity; Region: Abi; pfam02517
246198001924	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
246198001925	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
246198001926	active site
246198001927	Riboflavin kinase; Region: Flavokinase; pfam01687
246198001928	Protein of unknown function DUF45; Region: DUF45; pfam01863
246198001929	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
246198001930	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
246198001931	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198001932	ATP binding site [chemical binding]; other site
246198001933	putative Mg++ binding site [ion binding]; other site
246198001934	HsdM N-terminal domain; Region: HsdM_N; pfam12161
246198001935	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
246198001936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198001937	S-adenosylmethionine binding site [chemical binding]; other site
246198001938	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
246198001939	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
246198001940	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
246198001941	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
246198001942	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
246198001943	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
246198001944	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198001945	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198001946	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
246198001947	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120
246198001948	Walker A motif; other site
246198001949	ATP binding site [chemical binding]; other site
246198001950	Walker B motif; other site
246198001951	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198001952	AAA domain; Region: AAA_14; pfam13173
246198001953	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
246198001954	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
246198001955	WbqC-like protein family; Region: WbqC; pfam08889
246198001956	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
246198001957	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
246198001958	Catalytic site [active]
246198001959	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
246198001960	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
246198001961	dihydrodipicolinate reductase; Provisional; Region: PRK00048
246198001962	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
246198001963	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
246198001964	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
246198001965	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
246198001966	active site
246198001967	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
246198001968	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
246198001969	active site
246198001970	DNA protecting protein DprA; Region: dprA; TIGR00732
246198001971	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
246198001972	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
246198001973	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
246198001974	active site
246198001975	metal binding site [ion binding]; metal-binding site
246198001976	homotetramer interface [polypeptide binding]; other site
246198001977	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
246198001978	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
246198001979	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246198001980	catalytic residues [active]
246198001981	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
246198001982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
246198001983	glutathione-disulfide reductase, animal/bacterial; Region: gluta_reduc_1; TIGR01421
246198001984	CO dehydrogenase/acetyl-CoA synthase beta subunit [Energy production and conversion]; Region: CdhC; COG1614
246198001985	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
246198001986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198001987	ATP binding site [chemical binding]; other site
246198001988	Mg2+ binding site [ion binding]; other site
246198001989	G-X-G motif; other site
246198001990	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
246198001991	ATP binding site [chemical binding]; other site
246198001992	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
246198001993	active site
246198001994	putative metal-binding site [ion binding]; other site
246198001995	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
246198001996	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246198001997	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
246198001998	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
246198001999	protein binding site [polypeptide binding]; other site
246198002000	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
246198002001	Catalytic dyad [active]
246198002002	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198002003	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198002004	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
246198002005	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
246198002006	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002007	active site
246198002008	nucleotide binding site [chemical binding]; other site
246198002009	HIGH motif; other site
246198002010	KMSKS motif; other site
246198002011	Clostripain family; Region: Peptidase_C11; pfam03415
246198002012	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
246198002013	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
246198002014	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
246198002015	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
246198002016	putative Iron-sulfur protein interface [polypeptide binding]; other site
246198002017	proximal heme binding site [chemical binding]; other site
246198002018	distal heme binding site [chemical binding]; other site
246198002019	putative dimer interface [polypeptide binding]; other site
246198002020	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
246198002021	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
246198002022	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
246198002023	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198002024	active site
246198002025	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
246198002026	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
246198002027	GIY-YIG motif/motif A; other site
246198002028	active site
246198002029	catalytic site [active]
246198002030	putative DNA binding site [nucleotide binding]; other site
246198002031	metal binding site [ion binding]; metal-binding site
246198002032	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
246198002033	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
246198002034	putative active site [active]
246198002035	dimerization interface [polypeptide binding]; other site
246198002036	putative tRNAtyr binding site [nucleotide binding]; other site
246198002037	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
246198002038	homodimer interface [polypeptide binding]; other site
246198002039	metal binding site [ion binding]; metal-binding site
246198002040	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
246198002041	intersubunit interface [polypeptide binding]; other site
246198002042	active site
246198002043	catalytic residue [active]
246198002044	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
246198002045	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
246198002046	substrate binding pocket [chemical binding]; other site
246198002047	chain length determination region; other site
246198002048	substrate-Mg2+ binding site; other site
246198002049	catalytic residues [active]
246198002050	aspartate-rich region 1; other site
246198002051	active site lid residues [active]
246198002052	aspartate-rich region 2; other site
246198002053	DNA polymerase I; Provisional; Region: PRK05755
246198002054	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
246198002055	active site
246198002056	metal binding site 1 [ion binding]; metal-binding site
246198002057	putative 5' ssDNA interaction site; other site
246198002058	metal binding site 3; metal-binding site
246198002059	metal binding site 2 [ion binding]; metal-binding site
246198002060	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
246198002061	putative DNA binding site [nucleotide binding]; other site
246198002062	putative metal binding site [ion binding]; other site
246198002063	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
246198002064	active site
246198002065	catalytic site [active]
246198002066	substrate binding site [chemical binding]; other site
246198002067	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
246198002068	active site
246198002069	DNA binding site [nucleotide binding]
246198002070	catalytic site [active]
246198002071	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
246198002072	DNA photolyase; Region: DNA_photolyase; pfam00875
246198002073	Peptidase family U32; Region: Peptidase_U32; pfam01136
246198002074	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
246198002075	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
246198002076	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
246198002077	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
246198002078	active site
246198002079	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
246198002080	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
246198002081	active site
246198002082	HIGH motif; other site
246198002083	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
246198002084	active site
246198002085	KMSKS motif; other site
246198002086	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
246198002087	tRNA binding surface [nucleotide binding]; other site
246198002088	anticodon binding site; other site
246198002089	hypothetical protein; Provisional; Region: PRK02877
246198002090	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
246198002091	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
246198002092	MutS domain I; Region: MutS_I; pfam01624
246198002093	MutS domain II; Region: MutS_II; pfam05188
246198002094	MutS domain III; Region: MutS_III; pfam05192
246198002095	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
246198002096	Walker A/P-loop; other site
246198002097	ATP binding site [chemical binding]; other site
246198002098	Q-loop/lid; other site
246198002099	ABC transporter signature motif; other site
246198002100	Walker B; other site
246198002101	D-loop; other site
246198002102	H-loop/switch region; other site
246198002103	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
246198002104	GTP-binding protein YchF; Reviewed; Region: PRK09601
246198002105	YchF GTPase; Region: YchF; cd01900
246198002106	Switch II region; other site
246198002107	G3 box; other site
246198002108	GTP/Mg2+ binding site [chemical binding]; other site
246198002109	G4 box; other site
246198002110	G5 box; other site
246198002111	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
246198002112	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
246198002113	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
246198002114	dimerization interface [polypeptide binding]; other site
246198002115	active site
246198002116	metal binding site [ion binding]; metal-binding site
246198002117	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
246198002118	dsRNA binding site [nucleotide binding]; other site
246198002119	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
246198002120	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
246198002121	dimer interface [polypeptide binding]; other site
246198002122	active site
246198002123	acyl carrier protein; Provisional; Region: acpP; PRK00982
246198002124	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
246198002125	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
246198002126	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
246198002127	putative active site [active]
246198002128	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
246198002129	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002130	active site
246198002131	HIGH motif; other site
246198002132	nucleotide binding site [chemical binding]; other site
246198002133	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
246198002134	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002135	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002136	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002137	active site
246198002138	KMSKS motif; other site
246198002139	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
246198002140	tRNA binding surface [nucleotide binding]; other site
246198002141	Uncharacterized conserved protein [Function unknown]; Region: COG1284
246198002142	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
246198002143	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
246198002144	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
246198002145	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
246198002146	active site
246198002147	dimerization interface [polypeptide binding]; other site
246198002148	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246198002149	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
246198002150	active site
246198002151	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
246198002152	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
246198002153	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
246198002154	AAA domain; Region: AAA_33; pfam13671
246198002155	P-loop motif; other site
246198002156	ATP binding site [chemical binding]; other site
246198002157	Chloramphenicol (Cm) binding site [chemical binding]; other site
246198002158	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
246198002159	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
246198002160	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
246198002161	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
246198002162	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
246198002163	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
246198002164	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198002165	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198002166	DNA binding residues [nucleotide binding]
246198002167	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
246198002168	putative protease; Region: PHA00666
246198002169	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
246198002170	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
246198002171	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
246198002172	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
246198002173	AIR carboxylase; Region: AIRC; pfam00731
246198002174	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
246198002175	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
246198002176	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
246198002177	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198002178	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198002179	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198002180	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
246198002181	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
246198002182	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246198002183	active site
246198002184	ribonuclease R; Region: RNase_R; TIGR02063
246198002185	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
246198002186	RNB domain; Region: RNB; pfam00773
246198002187	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
246198002188	RNA binding site [nucleotide binding]; other site
246198002189	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
246198002190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246198002191	NAD(P) binding site [chemical binding]; other site
246198002192	active site
246198002193	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
246198002194	active site
246198002195	AAA ATPase domain; Region: AAA_16; pfam13191
246198002196	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
246198002197	Bacterial Ig-like domain; Region: Big_5; pfam13205
246198002198	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
246198002199	GH3 auxin-responsive promoter; Region: GH3; pfam03321
246198002200	putative transporter; Validated; Region: PRK03818
246198002201	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
246198002202	TrkA-C domain; Region: TrkA_C; pfam02080
246198002203	TrkA-C domain; Region: TrkA_C; pfam02080
246198002204	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
246198002205	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
246198002206	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
246198002207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198002208	Walker A motif; other site
246198002209	ATP binding site [chemical binding]; other site
246198002210	Walker B motif; other site
246198002211	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
246198002212	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
246198002213	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
246198002214	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246198002215	catalytic residues [active]
246198002216	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
246198002217	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198002218	active site
246198002219	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
246198002220	Substrate binding site [chemical binding]; other site
246198002221	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
246198002222	Histidine kinase; Region: His_kinase; pfam06580
246198002223	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
246198002224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198002225	active site
246198002226	phosphorylation site [posttranslational modification]
246198002227	intermolecular recognition site; other site
246198002228	dimerization interface [polypeptide binding]; other site
246198002229	LytTr DNA-binding domain; Region: LytTR; smart00850
246198002230	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
246198002231	active site
246198002232	M28 Zn-Peptidases; Region: M28_like_6; cd08656
246198002233	Peptidase family M28; Region: Peptidase_M28; pfam04389
246198002234	metal binding site [ion binding]; metal-binding site
246198002235	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
246198002236	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
246198002237	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
246198002238	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
246198002239	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
246198002240	active site
246198002241	dimer interface [polypeptide binding]; other site
246198002242	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
246198002243	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
246198002244	putative DNA binding site [nucleotide binding]; other site
246198002245	putative Zn2+ binding site [ion binding]; other site
246198002246	AsnC family; Region: AsnC_trans_reg; pfam01037
246198002247	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
246198002248	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
246198002249	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
246198002250	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
246198002251	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
246198002252	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
246198002253	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
246198002254	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
246198002255	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
246198002256	NAD-dependent deacetylase; Provisional; Region: PRK00481
246198002257	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
246198002258	NAD+ binding site [chemical binding]; other site
246198002259	substrate binding site [chemical binding]; other site
246198002260	Zn binding site [ion binding]; other site
246198002261	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
246198002262	catalytic residues [active]
246198002263	dimer interface [polypeptide binding]; other site
246198002264	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
246198002265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
246198002266	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
246198002267	dimerization interface [polypeptide binding]; other site
246198002268	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
246198002269	Uncharacterized conserved protein [Function unknown]; Region: COG2966
246198002270	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
246198002271	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
246198002272	thiamine phosphate binding site [chemical binding]; other site
246198002273	active site
246198002274	pyrophosphate binding site [ion binding]; other site
246198002275	ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176
246198002276	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
246198002277	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
246198002278	ThiC-associated domain; Region: ThiC-associated; pfam13667
246198002279	ThiC family; Region: ThiC; pfam01964
246198002280	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
246198002281	active site
246198002282	thiamine phosphate binding site [chemical binding]; other site
246198002283	pyrophosphate binding site [ion binding]; other site
246198002284	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
246198002285	dimer interface [polypeptide binding]; other site
246198002286	substrate binding site [chemical binding]; other site
246198002287	ATP binding site [chemical binding]; other site
246198002288	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
246198002289	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198002290	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
246198002291	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
246198002292	N-terminal plug; other site
246198002293	ligand-binding site [chemical binding]; other site
246198002294	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246198002295	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246198002296	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246198002297	Predicted integral membrane protein [Function unknown]; Region: COG5652
246198002298	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
246198002299	putative active site [active]
246198002300	putative metal binding residues [ion binding]; other site
246198002301	signature motif; other site
246198002302	putative dimer interface [polypeptide binding]; other site
246198002303	putative phosphate binding site [ion binding]; other site
246198002304	peptide chain release factor 2; Validated; Region: prfB; PRK00578
246198002305	This domain is found in peptide chain release factors; Region: PCRF; smart00937
246198002306	RF-1 domain; Region: RF-1; pfam00472
246198002307	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
246198002308	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
246198002309	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
246198002310	acyl-activating enzyme (AAE) consensus motif; other site
246198002311	acyl-activating enzyme (AAE) consensus motif; other site
246198002312	putative AMP binding site [chemical binding]; other site
246198002313	putative active site [active]
246198002314	putative CoA binding site [chemical binding]; other site
246198002315	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
246198002316	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
246198002317	active site
246198002318	Zn binding site [ion binding]; other site
246198002319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
246198002320	DNA-binding site [nucleotide binding]; DNA binding site
246198002321	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
246198002322	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
246198002323	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
246198002324	Walker A/P-loop; other site
246198002325	ATP binding site [chemical binding]; other site
246198002326	Q-loop/lid; other site
246198002327	ABC transporter signature motif; other site
246198002328	Walker B; other site
246198002329	D-loop; other site
246198002330	H-loop/switch region; other site
246198002331	arginine repressor; Region: argR_whole; TIGR01529
246198002332	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
246198002333	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
246198002334	Uncharacterized conserved protein [Function unknown]; Region: COG1624
246198002335	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
246198002336	dihydropteroate synthase; Region: DHPS; TIGR01496
246198002337	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
246198002338	substrate binding pocket [chemical binding]; other site
246198002339	dimer interface [polypeptide binding]; other site
246198002340	inhibitor binding site; inhibition site
246198002341	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
246198002342	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
246198002343	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
246198002344	PhoU domain; Region: PhoU; pfam01895
246198002345	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
246198002346	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
246198002347	active site
246198002348	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002349	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002350	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
246198002351	Sulfatase; Region: Sulfatase; cl17466
246198002352	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
246198002353	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
246198002354	active site
246198002355	HIGH motif; other site
246198002356	dimer interface [polypeptide binding]; other site
246198002357	KMSKS motif; other site
246198002358	ribonuclease P; Reviewed; Region: rnpA; PRK01903
246198002359	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
246198002360	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
246198002361	active site
246198002362	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
246198002363	S-adenosylmethionine synthetase; Validated; Region: PRK05250
246198002364	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
246198002365	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
246198002366	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
246198002367	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
246198002368	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198002369	active site
246198002370	RecX family; Region: RecX; pfam02631
246198002371	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
246198002372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198002373	S-adenosylmethionine binding site [chemical binding]; other site
246198002374	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
246198002375	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
246198002376	catalytic motif [active]
246198002377	Zn binding site [ion binding]; other site
246198002378	RibD C-terminal domain; Region: RibD_C; cl17279
246198002379	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002380	pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510
246198002381	active site
246198002382	nucleotide binding site [chemical binding]; other site
246198002383	HIGH motif; other site
246198002384	KMSKS motif; other site
246198002385	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
246198002386	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
246198002387	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
246198002388	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246198002389	catalytic residue [active]
246198002390	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
246198002391	LicD family; Region: LicD; cl01378
246198002392	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
246198002393	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
246198002394	putative acyl-acceptor binding pocket; other site
246198002395	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
246198002396	EamA-like transporter family; Region: EamA; pfam00892
246198002397	Sulfatase; Region: Sulfatase; cl17466
246198002398	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246198002399	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198002400	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
246198002401	Walker A/P-loop; other site
246198002402	ATP binding site [chemical binding]; other site
246198002403	Q-loop/lid; other site
246198002404	ABC transporter signature motif; other site
246198002405	Walker B; other site
246198002406	D-loop; other site
246198002407	H-loop/switch region; other site
246198002408	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
246198002409	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
246198002410	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198002411	FeS/SAM binding site; other site
246198002412	TRAM domain; Region: TRAM; pfam01938
246198002413	L-lactate permease; Region: Lactate_perm; cl00701
246198002414	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
246198002415	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
246198002416	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
246198002417	Walker A/P-loop; other site
246198002418	ATP binding site [chemical binding]; other site
246198002419	Q-loop/lid; other site
246198002420	ABC transporter signature motif; other site
246198002421	Walker B; other site
246198002422	D-loop; other site
246198002423	H-loop/switch region; other site
246198002424	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
246198002425	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
246198002426	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198002427	active site
246198002428	HIGH motif; other site
246198002429	nucleotide binding site [chemical binding]; other site
246198002430	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
246198002431	KMSK motif region; other site
246198002432	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
246198002433	tRNA binding surface [nucleotide binding]; other site
246198002434	anticodon binding site; other site
246198002435	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
246198002436	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
246198002437	active site
246198002438	RNA/DNA hybrid binding site [nucleotide binding]; other site
246198002439	glutamate racemase; Provisional; Region: PRK00865
246198002440	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
246198002441	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
246198002442	periplasmic chaperone; Provisional; Region: PRK10780
246198002443	periplasmic chaperone; Provisional; Region: PRK10780
246198002444	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
246198002445	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
246198002446	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246198002447	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246198002448	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246198002449	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246198002450	Surface antigen; Region: Bac_surface_Ag; pfam01103
246198002451	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838
246198002452	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
246198002453	catalytic residue [active]
246198002454	putative FPP diphosphate  binding site; other site
246198002455	putative FPP binding hydrophobic cleft; other site
246198002456	dimer interface [polypeptide binding]; other site
246198002457	putative IPP diphosphate binding site; other site
246198002458	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
246198002459	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
246198002460	Peptidase family C69; Region: Peptidase_C69; cl17793
246198002461	Outer membrane protein Omp28; Region: Omp28; pfam11551
246198002462	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198002463	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198002464	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
246198002465	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
246198002466	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
246198002467	active site
246198002468	multimer interface [polypeptide binding]; other site
246198002469	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
246198002470	predicted active site [active]
246198002471	catalytic triad [active]
246198002472	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246198002473	IHF dimer interface [polypeptide binding]; other site
246198002474	IHF - DNA interface [nucleotide binding]; other site
246198002475	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
246198002476	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
246198002477	putative catalytic site [active]
246198002478	putative metal binding site [ion binding]; other site
246198002479	putative phosphate binding site [ion binding]; other site
246198002480	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
246198002481	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
246198002482	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
246198002483	Protein export membrane protein; Region: SecD_SecF; pfam02355
246198002484	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
246198002485	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
246198002486	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
246198002487	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
246198002488	nucleotide binding site/active site [active]
246198002489	HIT family signature motif; other site
246198002490	catalytic residue [active]
246198002491	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
246198002492	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
246198002493	Substrate binding site; other site
246198002494	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
246198002495	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
246198002496	mismatch recognition site; other site
246198002497	additional DNA contacts [nucleotide binding]; other site
246198002498	active site
246198002499	zinc binding site [ion binding]; other site
246198002500	DNA intercalation site [nucleotide binding]; other site
246198002501	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198002502	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
246198002503	putative active site [active]
246198002504	putative metal binding site [ion binding]; other site
246198002505	Domain of unknown function DUF59; Region: DUF59; cl00941
246198002506	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
246198002507	DNA binding site [nucleotide binding]
246198002508	Predicted membrane protein [Function unknown]; Region: COG3059
246198002509	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198002510	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198002511	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198002512	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
246198002513	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002514	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
246198002515	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
246198002516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198002517	Walker A motif; other site
246198002518	ATP binding site [chemical binding]; other site
246198002519	Walker B motif; other site
246198002520	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
246198002521	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
246198002522	active site
246198002523	HIGH motif; other site
246198002524	KMSKS motif; other site
246198002525	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
246198002526	tRNA binding surface [nucleotide binding]; other site
246198002527	anticodon binding site; other site
246198002528	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
246198002529	dimer interface [polypeptide binding]; other site
246198002530	putative tRNA-binding site [nucleotide binding]; other site
246198002531	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198002532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198002533	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
246198002534	CoA binding domain; Region: CoA_binding; smart00881
246198002535	CoA-ligase; Region: Ligase_CoA; pfam00549
246198002536	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
246198002537	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
246198002538	CoA-ligase; Region: Ligase_CoA; pfam00549
246198002539	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
246198002540	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
246198002541	TPP-binding site [chemical binding]; other site
246198002542	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
246198002543	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
246198002544	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
246198002545	dimer interface [polypeptide binding]; other site
246198002546	PYR/PP interface [polypeptide binding]; other site
246198002547	TPP binding site [chemical binding]; other site
246198002548	substrate binding site [chemical binding]; other site
246198002549	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
246198002550	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
246198002551	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
246198002552	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
246198002553	Penicillinase repressor; Region: Pencillinase_R; pfam03965
246198002554	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
246198002555	Interdomain contacts; other site
246198002556	Cytokine receptor motif; other site
246198002557	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002558	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
246198002559	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
246198002560	dimer interface [polypeptide binding]; other site
246198002561	substrate binding site [chemical binding]; other site
246198002562	ATP binding site [chemical binding]; other site
246198002563	Beta-lactamase; Region: Beta-lactamase; cl17358
246198002564	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198002565	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198002566	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198002567	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
246198002568	active site
246198002569	Int/Topo IB signature motif; other site
246198002570	DNA binding site [nucleotide binding]
246198002571	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
246198002572	Dehydroquinase class II; Region: DHquinase_II; pfam01220
246198002573	active site
246198002574	trimer interface [polypeptide binding]; other site
246198002575	dimer interface [polypeptide binding]; other site
246198002576	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
246198002577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198002578	S-adenosylmethionine binding site [chemical binding]; other site
246198002579	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198002580	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
246198002581	GLPGLI family protein; Region: GLPGLI; TIGR01200
246198002582	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
246198002583	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
246198002584	substrate-cofactor binding pocket; other site
246198002585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198002586	catalytic residue [active]
246198002587	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
246198002588	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246198002589	NAD(P) binding site [chemical binding]; other site
246198002590	active site
246198002591	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
246198002592	propionate/acetate kinase; Provisional; Region: PRK12379
246198002593	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
246198002594	AAA domain; Region: AAA_11; pfam13086
246198002595	AAA domain; Region: AAA_30; pfam13604
246198002596	AAA domain; Region: AAA_12; pfam13087
246198002597	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
246198002598	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
246198002599	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
246198002600	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
246198002601	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
246198002602	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
246198002603	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
246198002604	trimer interface [polypeptide binding]; other site
246198002605	active site
246198002606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198002607	TPR motif; other site
246198002608	TPR repeat; Region: TPR_11; pfam13414
246198002609	binding surface
246198002610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198002611	TPR motif; other site
246198002612	binding surface
246198002613	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
246198002614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
246198002615	Peptidase family M23; Region: Peptidase_M23; pfam01551
246198002616	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198002617	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198002618	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
246198002619	Leucine-rich repeats; other site
246198002620	Substrate binding site [chemical binding]; other site
246198002621	Leucine rich repeat; Region: LRR_8; pfam13855
246198002622	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
246198002623	active site
246198002624	nucleophile elbow; other site
246198002625	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
246198002626	Int/Topo IB signature motif; other site
246198002627	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
246198002628	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198002629	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198002630	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198002631	Methyltransferase domain; Region: Methyltransf_26; pfam13659
246198002632	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
246198002633	DEAD-like helicases superfamily; Region: DEXDc; smart00487
246198002634	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
246198002635	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
246198002636	nucleotide binding region [chemical binding]; other site
246198002637	helicase superfamily c-terminal domain; Region: HELICc; smart00490
246198002638	ATP-binding site [chemical binding]; other site
246198002639	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
246198002640	DNA topoisomerase III; Provisional; Region: PRK07726
246198002641	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
246198002642	active site
246198002643	putative interdomain interaction site [polypeptide binding]; other site
246198002644	putative metal-binding site [ion binding]; other site
246198002645	putative nucleotide binding site [chemical binding]; other site
246198002646	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
246198002647	domain I; other site
246198002648	DNA binding groove [nucleotide binding]
246198002649	phosphate binding site [ion binding]; other site
246198002650	domain II; other site
246198002651	domain III; other site
246198002652	nucleotide binding site [chemical binding]; other site
246198002653	catalytic site [active]
246198002654	domain IV; other site
246198002655	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
246198002656	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
246198002657	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
246198002658	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
246198002659	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246198002660	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198002661	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198002662	Walker A/P-loop; other site
246198002663	ATP binding site [chemical binding]; other site
246198002664	Q-loop/lid; other site
246198002665	ABC transporter signature motif; other site
246198002666	Walker B; other site
246198002667	D-loop; other site
246198002668	H-loop/switch region; other site
246198002669	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246198002670	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198002671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198002672	Walker A/P-loop; other site
246198002673	ATP binding site [chemical binding]; other site
246198002674	Q-loop/lid; other site
246198002675	ABC transporter signature motif; other site
246198002676	Walker B; other site
246198002677	D-loop; other site
246198002678	H-loop/switch region; other site
246198002679	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198002680	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198002681	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
246198002682	N-terminal plug; other site
246198002683	ligand-binding site [chemical binding]; other site
246198002684	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
246198002685	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
246198002686	Histidine kinase; Region: His_kinase; pfam06580
246198002687	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
246198002688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198002689	active site
246198002690	phosphorylation site [posttranslational modification]
246198002691	intermolecular recognition site; other site
246198002692	dimerization interface [polypeptide binding]; other site
246198002693	LytTr DNA-binding domain; Region: LytTR; smart00850
246198002694	Amastin surface glycoprotein; Region: Amastin; cl06401
246198002695	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
246198002696	RteC protein; Region: RteC; pfam09357
246198002697	YWFCY protein; Region: YWFCY; pfam14293
246198002698	AAA-like domain; Region: AAA_10; pfam12846
246198002699	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
246198002700	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
246198002701	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
246198002702	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
246198002703	P-loop; other site
246198002704	Magnesium ion binding site [ion binding]; other site
246198002705	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198002706	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198002707	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
246198002708	AAA-like domain; Region: AAA_10; pfam12846
246198002709	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
246198002710	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
246198002711	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
246198002712	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
246198002713	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
246198002714	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
246198002715	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
246198002716	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
246198002717	Conjugative transposon protein TraO; Region: TraO; pfam10626
246198002718	CHC2 zinc finger; Region: zf-CHC2; cl17510
246198002719	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
246198002720	active site
246198002721	metal binding site [ion binding]; metal-binding site
246198002722	interdomain interaction site; other site
246198002723	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
246198002724	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
246198002725	catalytic residue [active]
246198002726	AAA ATPase domain; Region: AAA_15; pfam13175
246198002727	P-loop containing region of AAA domain; Region: AAA_29; cl17516
246198002728	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
246198002729	putative active site [active]
246198002730	putative metal-binding site [ion binding]; other site
246198002731	Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443
246198002732	PcfJ-like protein; Region: PcfJ; pfam14284
246198002733	Antirestriction protein (ArdA); Region: ArdA; cl01953
246198002734	PcfK-like protein; Region: PcfK; pfam14058
246198002735	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198002736	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
246198002737	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198002738	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
246198002739	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
246198002740	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
246198002741	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
246198002742	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
246198002743	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198002744	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198002745	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
246198002746	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
246198002747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198002748	homodimer interface [polypeptide binding]; other site
246198002749	catalytic residue [active]
246198002750	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
246198002751	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198002752	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198002753	DNA binding residues [nucleotide binding]
246198002754	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
246198002755	FecR protein; Region: FecR; pfam04773
246198002756	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198002757	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198002758	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198002759	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
246198002760	gliding motility associated protien GldN; Region: GldN; TIGR03523
246198002761	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
246198002762	GldM N-terminal domain; Region: GldM_N; pfam12081
246198002763	GldM C-terminal domain; Region: GldM_C; pfam12080
246198002764	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
246198002765	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
246198002766	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
246198002767	Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519
246198002768	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
246198002769	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
246198002770	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246198002771	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198002772	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198002773	AAA domain; Region: AAA_22; pfam13401
246198002774	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
246198002775	Walker A motif; other site
246198002776	ATP binding site [chemical binding]; other site
246198002777	Walker B motif; other site
246198002778	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
246198002779	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
246198002780	anaerobic sulfatase-maturase; Provisional; Region: PRK13745
246198002781	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
246198002782	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
246198002783	potential frameshift: common BLAST hit: gi|325279523|ref|YP_004252065.1| phage head morphogenesis protein, SPP1 gp7 family
246198002784	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
246198002785	Protein of unknown function (DUF935); Region: DUF935; pfam06074
246198002786	Protein of unknown function (DUF1320); Region: DUF1320; cl01818
246198002787	Terminase-like family; Region: Terminase_6; pfam03237
246198002788	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
246198002789	DNA-binding interface [nucleotide binding]; DNA binding site
246198002790	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
246198002791	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
246198002792	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
246198002793	tape measure domain; Region: tape_meas_nterm; TIGR02675
246198002794	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
246198002795	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
246198002796	dimerization interface [polypeptide binding]; other site
246198002797	active site
246198002798	AAA domain; Region: AAA_21; pfam13304
246198002799	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
246198002800	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198002801	Toprim-like; Region: Toprim_2; pfam13155
246198002802	Virulence-associated protein E; Region: VirE; pfam05272
246198002803	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198002804	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198002805	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198002806	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198002807	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
246198002808	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
246198002809	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
246198002810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198002811	Radical SAM superfamily; Region: Radical_SAM; pfam04055
246198002812	FeS/SAM binding site; other site
246198002813	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198002814	active site
246198002815	Int/Topo IB signature motif; other site
246198002816	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
246198002817	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
246198002818	Int/Topo IB signature motif; other site
246198002819	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
246198002820	Int/Topo IB signature motif; other site
246198002821	Virulence protein [General function prediction only]; Region: COG3943
246198002822	SnoaL-like domain; Region: SnoaL_2; pfam12680
246198002823	Predicted transcriptional regulators [Transcription]; Region: COG1733
246198002824	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
246198002825	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
246198002826	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198002827	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198002828	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
246198002829	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
246198002830	RteC protein; Region: RteC; pfam09357
246198002831	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198002832	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198002833	active site
246198002834	Int/Topo IB signature motif; other site
246198002835	DNA binding site [nucleotide binding]
246198002836	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198002837	active site
246198002838	DNA binding site [nucleotide binding]
246198002839	Int/Topo IB signature motif; other site
246198002840	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
246198002841	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
246198002842	active site
246198002843	HIGH motif; other site
246198002844	dimer interface [polypeptide binding]; other site
246198002845	KMSKS motif; other site
246198002846	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
246198002847	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
246198002848	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
246198002849	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
246198002850	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
246198002851	HIGH motif; other site
246198002852	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
246198002853	active site
246198002854	KMSKS motif; other site
246198002855	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
246198002856	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
246198002857	Zn2+ binding site [ion binding]; other site
246198002858	Mg2+ binding site [ion binding]; other site
246198002859	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
246198002860	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198002861	ATP binding site [chemical binding]; other site
246198002862	putative Mg++ binding site [ion binding]; other site
246198002863	helicase superfamily c-terminal domain; Region: HELICc; smart00490
246198002864	ATP-binding site [chemical binding]; other site
246198002865	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
246198002866	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
246198002867	NAD(P) binding site [chemical binding]; other site
246198002868	LDH/MDH dimer interface [polypeptide binding]; other site
246198002869	substrate binding site [chemical binding]; other site
246198002870	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
246198002871	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
246198002872	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
246198002873	DNA binding site [nucleotide binding]
246198002874	active site
246198002875	Outer membrane protein Omp28; Region: Omp28; pfam11551
246198002876	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002877	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
246198002878	Interdomain contacts; other site
246198002879	Cytokine receptor motif; other site
246198002880	CARDB; Region: CARDB; pfam07705
246198002881	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002882	Fibronectin type 3 domain; Region: FN3; smart00060
246198002883	CARDB; Region: CARDB; pfam07705
246198002884	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002885	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
246198002886	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
246198002887	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
246198002888	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246198002889	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
246198002890	protein binding site [polypeptide binding]; other site
246198002891	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
246198002892	Domain interface; other site
246198002893	Peptide binding site; other site
246198002894	Active site tetrad [active]
246198002895	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
246198002896	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
246198002897	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
246198002898	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
246198002899	active site
246198002900	Beta-lactamase; Region: Beta-lactamase; pfam00144
246198002901	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
246198002902	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
246198002903	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198002904	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
246198002905	active site
246198002906	DNA binding site [nucleotide binding]
246198002907	Int/Topo IB signature motif; other site
246198002908	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
246198002909	30S subunit binding site; other site
246198002910	elongation factor Tu; Reviewed; Region: PRK12735
246198002911	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
246198002912	G1 box; other site
246198002913	GEF interaction site [polypeptide binding]; other site
246198002914	GTP/Mg2+ binding site [chemical binding]; other site
246198002915	Switch I region; other site
246198002916	G2 box; other site
246198002917	G3 box; other site
246198002918	Switch II region; other site
246198002919	G4 box; other site
246198002920	G5 box; other site
246198002921	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
246198002922	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
246198002923	Antibiotic Binding Site [chemical binding]; other site
246198002924	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
246198002925	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
246198002926	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
246198002927	putative homodimer interface [polypeptide binding]; other site
246198002928	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
246198002929	heterodimer interface [polypeptide binding]; other site
246198002930	homodimer interface [polypeptide binding]; other site
246198002931	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
246198002932	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
246198002933	23S rRNA interface [nucleotide binding]; other site
246198002934	L7/L12 interface [polypeptide binding]; other site
246198002935	putative thiostrepton binding site; other site
246198002936	L25 interface [polypeptide binding]; other site
246198002937	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
246198002938	mRNA/rRNA interface [nucleotide binding]; other site
246198002939	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
246198002940	23S rRNA interface [nucleotide binding]; other site
246198002941	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
246198002942	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
246198002943	core dimer interface [polypeptide binding]; other site
246198002944	peripheral dimer interface [polypeptide binding]; other site
246198002945	L10 interface [polypeptide binding]; other site
246198002946	L11 interface [polypeptide binding]; other site
246198002947	putative EF-Tu interaction site [polypeptide binding]; other site
246198002948	putative EF-G interaction site [polypeptide binding]; other site
246198002949	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
246198002950	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
246198002951	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
246198002952	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
246198002953	RPB12 interaction site [polypeptide binding]; other site
246198002954	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
246198002955	RPB11 interaction site [polypeptide binding]; other site
246198002956	RPB12 interaction site [polypeptide binding]; other site
246198002957	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
246198002958	RPB3 interaction site [polypeptide binding]; other site
246198002959	RPB1 interaction site [polypeptide binding]; other site
246198002960	RPB11 interaction site [polypeptide binding]; other site
246198002961	RPB10 interaction site [polypeptide binding]; other site
246198002962	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
246198002963	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
246198002964	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
246198002965	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
246198002966	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
246198002967	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
246198002968	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
246198002969	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
246198002970	DNA binding site [nucleotide binding]
246198002971	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
246198002972	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
246198002973	conserved cys residue [active]
246198002974	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
246198002975	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198002976	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
246198002977	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
246198002978	16S rRNA interaction site [nucleotide binding]; other site
246198002979	streptomycin interaction site [chemical binding]; other site
246198002980	23S rRNA interaction site [nucleotide binding]; other site
246198002981	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
246198002982	30S ribosomal protein S7; Validated; Region: PRK05302
246198002983	elongation factor G; Reviewed; Region: PRK12739
246198002984	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
246198002985	G1 box; other site
246198002986	putative GEF interaction site [polypeptide binding]; other site
246198002987	GTP/Mg2+ binding site [chemical binding]; other site
246198002988	Switch I region; other site
246198002989	G2 box; other site
246198002990	G3 box; other site
246198002991	Switch II region; other site
246198002992	G4 box; other site
246198002993	G5 box; other site
246198002994	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
246198002995	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
246198002996	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
246198002997	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
246198002998	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
246198002999	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
246198003000	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
246198003001	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
246198003002	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
246198003003	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
246198003004	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
246198003005	putative translocon binding site; other site
246198003006	protein-rRNA interface [nucleotide binding]; other site
246198003007	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
246198003008	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
246198003009	G-X-X-G motif; other site
246198003010	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
246198003011	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
246198003012	23S rRNA interface [nucleotide binding]; other site
246198003013	5S rRNA interface [nucleotide binding]; other site
246198003014	putative antibiotic binding site [chemical binding]; other site
246198003015	L25 interface [polypeptide binding]; other site
246198003016	L27 interface [polypeptide binding]; other site
246198003017	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
246198003018	23S rRNA interface [nucleotide binding]; other site
246198003019	putative translocon interaction site; other site
246198003020	signal recognition particle (SRP54) interaction site; other site
246198003021	L23 interface [polypeptide binding]; other site
246198003022	trigger factor interaction site; other site
246198003023	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
246198003024	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
246198003025	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
246198003026	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
246198003027	RNA binding site [nucleotide binding]; other site
246198003028	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
246198003029	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
246198003030	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
246198003031	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
246198003032	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
246198003033	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
246198003034	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
246198003035	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
246198003036	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
246198003037	23S rRNA interface [nucleotide binding]; other site
246198003038	L21e interface [polypeptide binding]; other site
246198003039	5S rRNA interface [nucleotide binding]; other site
246198003040	L27 interface [polypeptide binding]; other site
246198003041	L5 interface [polypeptide binding]; other site
246198003042	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
246198003043	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
246198003044	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
246198003045	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
246198003046	23S rRNA binding site [nucleotide binding]; other site
246198003047	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
246198003048	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
246198003049	SecY translocase; Region: SecY; pfam00344
246198003050	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
246198003051	rRNA binding site [nucleotide binding]; other site
246198003052	predicted 30S ribosome binding site; other site
246198003053	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
246198003054	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
246198003055	30S ribosomal protein S13; Region: bact_S13; TIGR03631
246198003056	30S ribosomal protein S11; Validated; Region: PRK05309
246198003057	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
246198003058	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
246198003059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246198003060	RNA binding surface [nucleotide binding]; other site
246198003061	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
246198003062	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
246198003063	alphaNTD - beta interaction site [polypeptide binding]; other site
246198003064	alphaNTD homodimer interface [polypeptide binding]; other site
246198003065	alphaNTD - beta' interaction site [polypeptide binding]; other site
246198003066	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
246198003067	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
246198003068	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
246198003069	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
246198003070	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
246198003071	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
246198003072	putative active site [active]
246198003073	catalytic site [active]
246198003074	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
246198003075	putative active site [active]
246198003076	catalytic site [active]
246198003077	DNA primase, catalytic core; Region: dnaG; TIGR01391
246198003078	CHC2 zinc finger; Region: zf-CHC2; pfam01807
246198003079	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
246198003080	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
246198003081	active site
246198003082	metal binding site [ion binding]; metal-binding site
246198003083	interdomain interaction site; other site
246198003084	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
246198003085	Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190
246198003086	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198003087	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
246198003088	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
246198003089	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
246198003090	nucleotide binding site [chemical binding]; other site
246198003091	NEF interaction site [polypeptide binding]; other site
246198003092	SBD interface [polypeptide binding]; other site
246198003093	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
246198003094	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198003095	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
246198003096	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198003097	Virulence-associated protein E; Region: VirE; pfam05272
246198003098	CHC2 zinc finger; Region: zf-CHC2; cl17510
246198003099	Toprim-like; Region: Toprim_2; pfam13155
246198003100	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
246198003101	BRO family, N-terminal domain; Region: Bro-N; cl10591
246198003102	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
246198003103	Fic/DOC family; Region: Fic; pfam02661
246198003104	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
246198003105	Ion transport protein; Region: Ion_trans; pfam00520
246198003106	Ion channel; Region: Ion_trans_2; pfam07885
246198003107	BRO family, N-terminal domain; Region: Bro-N; cl10591
246198003108	Fic/DOC family; Region: Fic; cl00960
246198003109	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
246198003110	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
246198003111	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
246198003112	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
246198003113	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
246198003114	active site
246198003115	metal binding site [ion binding]; metal-binding site
246198003116	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
246198003117	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
246198003118	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
246198003119	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
246198003120	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198003121	Outer membrane efflux protein; Region: OEP; pfam02321
246198003122	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
246198003123	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
246198003124	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
246198003125	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
246198003126	Walker A/P-loop; other site
246198003127	ATP binding site [chemical binding]; other site
246198003128	Q-loop/lid; other site
246198003129	ABC transporter signature motif; other site
246198003130	Walker B; other site
246198003131	D-loop; other site
246198003132	H-loop/switch region; other site
246198003133	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198003134	Walker A/P-loop; other site
246198003135	ATP binding site [chemical binding]; other site
246198003136	Q-loop/lid; other site
246198003137	ABC transporter signature motif; other site
246198003138	Walker B; other site
246198003139	D-loop; other site
246198003140	H-loop/switch region; other site
246198003141	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
246198003142	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
246198003143	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
246198003144	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
246198003145	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
246198003146	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198003147	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
246198003148	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
246198003149	motif 1; other site
246198003150	active site
246198003151	motif 2; other site
246198003152	motif 3; other site
246198003153	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
246198003154	DHHA1 domain; Region: DHHA1; pfam02272
246198003155	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
246198003156	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
246198003157	DNA binding residues [nucleotide binding]
246198003158	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
246198003159	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
246198003160	GTPase CgtA; Reviewed; Region: obgE; PRK12298
246198003161	GTP1/OBG; Region: GTP1_OBG; pfam01018
246198003162	Obg GTPase; Region: Obg; cd01898
246198003163	G1 box; other site
246198003164	GTP/Mg2+ binding site [chemical binding]; other site
246198003165	Switch I region; other site
246198003166	G2 box; other site
246198003167	G3 box; other site
246198003168	Switch II region; other site
246198003169	G4 box; other site
246198003170	G5 box; other site
246198003171	adenylate kinase; Reviewed; Region: adk; PRK00279
246198003172	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
246198003173	AMP-binding site [chemical binding]; other site
246198003174	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
246198003175	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
246198003176	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
246198003177	putative substrate binding site [chemical binding]; other site
246198003178	putative ATP binding site [chemical binding]; other site
246198003179	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
246198003180	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
246198003181	intersubunit interface [polypeptide binding]; other site
246198003182	active site
246198003183	zinc binding site [ion binding]; other site
246198003184	Na+ binding site [ion binding]; other site
246198003185	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
246198003186	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
246198003187	active site
246198003188	recombinase A; Provisional; Region: recA; PRK09354
246198003189	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
246198003190	hexamer interface [polypeptide binding]; other site
246198003191	Walker A motif; other site
246198003192	ATP binding site [chemical binding]; other site
246198003193	Walker B motif; other site
246198003194	TfoX N-terminal domain; Region: TfoX_N; cl17592
246198003195	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
246198003196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246198003197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246198003198	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
246198003199	dimer interface [polypeptide binding]; other site
246198003200	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
246198003201	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
246198003202	Uncharacterized conserved protein [Function unknown]; Region: COG1284
246198003203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246198003204	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
246198003205	NAD(P) binding site [chemical binding]; other site
246198003206	active site
246198003207	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
246198003208	Phosphoglycerate kinase; Region: PGK; pfam00162
246198003209	substrate binding site [chemical binding]; other site
246198003210	hinge regions; other site
246198003211	ADP binding site [chemical binding]; other site
246198003212	catalytic site [active]
246198003213	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
246198003214	Ligand Binding Site [chemical binding]; other site
246198003215	Uncharacterized conserved protein [Function unknown]; Region: COG1284
246198003216	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
246198003217	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
246198003218	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
246198003219	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
246198003220	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
246198003221	trimer interface [polypeptide binding]; other site
246198003222	active site
246198003223	G bulge; other site
246198003224	SprT homologues; Region: SprT; cl01182
246198003225	AAA domain; Region: AAA_30; pfam13604
246198003226	Family description; Region: UvrD_C_2; pfam13538
246198003227	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
246198003228	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
246198003229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198003230	S-adenosylmethionine binding site [chemical binding]; other site
246198003231	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
246198003232	IHF dimer interface [polypeptide binding]; other site
246198003233	IHF - DNA interface [nucleotide binding]; other site
246198003234	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
246198003235	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
246198003236	RuvA N terminal domain; Region: RuvA_N; pfam01330
246198003237	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
246198003238	cell surface protein SprA; Region: surface_SprA; TIGR04189
246198003239	Motility related/secretion protein; Region: SprA_N; pfam14349
246198003240	Motility related/secretion protein; Region: SprA_N; pfam14349
246198003241	Motility related/secretion protein; Region: SprA_N; pfam14349
246198003242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
246198003243	Uncharacterized conserved protein [Function unknown]; Region: COG1262
246198003244	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
246198003245	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
246198003246	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
246198003247	putative dimer interface [polypeptide binding]; other site
246198003248	putative anticodon binding site; other site
246198003249	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
246198003250	homodimer interface [polypeptide binding]; other site
246198003251	motif 1; other site
246198003252	motif 2; other site
246198003253	active site
246198003254	motif 3; other site
246198003255	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
246198003256	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246198003257	RNA binding surface [nucleotide binding]; other site
246198003258	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
246198003259	active site
246198003260	adenylosuccinate lyase; Provisional; Region: PRK09285
246198003261	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
246198003262	tetramer interface [polypeptide binding]; other site
246198003263	active site
246198003264	MutS domain III; Region: MutS_III; cl17822
246198003265	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
246198003266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198003267	Walker A/P-loop; other site
246198003268	ATP binding site [chemical binding]; other site
246198003269	Q-loop/lid; other site
246198003270	ABC transporter signature motif; other site
246198003271	Walker B; other site
246198003272	D-loop; other site
246198003273	H-loop/switch region; other site
246198003274	glutamate dehydrogenase; Provisional; Region: PRK14030
246198003275	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
246198003276	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
246198003277	NAD(P) binding pocket [chemical binding]; other site
246198003278	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
246198003279	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
246198003280	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
246198003281	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
246198003282	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
246198003283	NlpE N-terminal domain; Region: NlpE; pfam04170
246198003284	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
246198003285	active site
246198003286	dimer interface [polypeptide binding]; other site
246198003287	metal binding site [ion binding]; metal-binding site
246198003288	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
246198003289	acyl-activating enzyme (AAE) consensus motif; other site
246198003290	AMP binding site [chemical binding]; other site
246198003291	active site
246198003292	CoA binding site [chemical binding]; other site
246198003293	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
246198003294	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
246198003295	active site
246198003296	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
246198003297	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
246198003298	substrate binding site [chemical binding]; other site
246198003299	oxyanion hole (OAH) forming residues; other site
246198003300	trimer interface [polypeptide binding]; other site
246198003301	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
246198003302	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
246198003303	dimer interface [polypeptide binding]; other site
246198003304	tetramer interface [polypeptide binding]; other site
246198003305	PYR/PP interface [polypeptide binding]; other site
246198003306	TPP binding site [chemical binding]; other site
246198003307	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
246198003308	TPP-binding site [chemical binding]; other site
246198003309	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
246198003310	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
246198003311	CoenzymeA binding site [chemical binding]; other site
246198003312	subunit interaction site [polypeptide binding]; other site
246198003313	PHB binding site; other site
246198003314	M6 family metalloprotease domain; Region: M6dom_TIGR03296
246198003315	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
246198003316	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
246198003317	dimer interface [polypeptide binding]; other site
246198003318	putative anticodon binding site; other site
246198003319	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
246198003320	motif 1; other site
246198003321	active site
246198003322	motif 2; other site
246198003323	motif 3; other site
246198003324	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
246198003325	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
246198003326	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
246198003327	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
246198003328	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
246198003329	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
246198003330	active site
246198003331	dimer interface [polypeptide binding]; other site
246198003332	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
246198003333	dimer interface [polypeptide binding]; other site
246198003334	active site
246198003335	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
246198003336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198003337	motif II; other site
246198003338	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
246198003339	Ligand binding site [chemical binding]; other site
246198003340	Electron transfer flavoprotein domain; Region: ETF; pfam01012
246198003341	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
246198003342	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
246198003343	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
246198003344	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
246198003345	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
246198003346	active site
246198003347	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
246198003348	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
246198003349	Lipocalin-like; Region: Lipocalin_3; pfam12702
246198003350	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
246198003351	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
246198003352	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
246198003353	Mechanosensitive ion channel; Region: MS_channel; pfam00924
246198003354	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
246198003355	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
246198003356	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
246198003357	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
246198003358	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
246198003359	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
246198003360	active site
246198003361	substrate binding site [chemical binding]; other site
246198003362	cosubstrate binding site; other site
246198003363	catalytic site [active]
246198003364	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246198003365	RNA binding surface [nucleotide binding]; other site
246198003366	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
246198003367	putative active site [active]
246198003368	catalytic residue [active]
246198003369	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
246198003370	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
246198003371	5S rRNA interface [nucleotide binding]; other site
246198003372	CTC domain interface [polypeptide binding]; other site
246198003373	L16 interface [polypeptide binding]; other site
246198003374	transcription antitermination factor NusB; Region: nusB; TIGR01951
246198003375	Preprotein translocase subunit; Region: YajC; pfam02699
246198003376	YbbR-like protein; Region: YbbR; pfam07949
246198003377	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
246198003378	dephospho-CoA kinase; Region: TIGR00152
246198003379	CoA-binding site [chemical binding]; other site
246198003380	ATP-binding [chemical binding]; other site
246198003381	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
246198003382	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
246198003383	putative dimer interface [polypeptide binding]; other site
246198003384	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
246198003385	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
246198003386	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
246198003387	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246198003388	catalytic residues [active]
246198003389	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
246198003390	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
246198003391	putative metal binding site [ion binding]; other site
246198003392	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
246198003393	HSP70 interaction site [polypeptide binding]; other site
246198003394	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
246198003395	putative transporter; Validated; Region: PRK03818
246198003396	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
246198003397	TrkA-C domain; Region: TrkA_C; pfam02080
246198003398	TrkA-C domain; Region: TrkA_C; pfam02080
246198003399	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
246198003400	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
246198003401	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
246198003402	active site
246198003403	metal binding site [ion binding]; metal-binding site
246198003404	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
246198003405	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
246198003406	Zn2+ binding site [ion binding]; other site
246198003407	Mg2+ binding site [ion binding]; other site
246198003408	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
246198003409	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
246198003410	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
246198003411	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
246198003412	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
246198003413	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
246198003414	TrkA-C domain; Region: TrkA_C; pfam02080
246198003415	TrkA-C domain; Region: TrkA_C; pfam02080
246198003416	peptidase T; Region: peptidase-T; TIGR01882
246198003417	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
246198003418	metal binding site [ion binding]; metal-binding site
246198003419	dimer interface [polypeptide binding]; other site
246198003420	Uncharacterized conserved protein [Function unknown]; Region: COG0327
246198003421	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
246198003422	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
246198003423	Putative zinc ribbon domain; Region: DUF164; pfam02591
246198003424	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
246198003425	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
246198003426	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
246198003427	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
246198003428	FAD binding pocket [chemical binding]; other site
246198003429	FAD binding motif [chemical binding]; other site
246198003430	phosphate binding motif [ion binding]; other site
246198003431	beta-alpha-beta structure motif; other site
246198003432	NAD binding pocket [chemical binding]; other site
246198003433	Iron coordination center [ion binding]; other site
246198003434	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
246198003435	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
246198003436	heterodimer interface [polypeptide binding]; other site
246198003437	active site
246198003438	FMN binding site [chemical binding]; other site
246198003439	homodimer interface [polypeptide binding]; other site
246198003440	substrate binding site [chemical binding]; other site
246198003441	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
246198003442	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
246198003443	Tetramer interface [polypeptide binding]; other site
246198003444	active site
246198003445	FMN-binding site [chemical binding]; other site
246198003446	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
246198003447	septation ring formation regulator EzrA; Provisional; Region: PRK04778
246198003448	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
246198003449	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198003450	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198003451	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198003452	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
246198003453	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
246198003454	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198003455	FeS/SAM binding site; other site
246198003456	HemN C-terminal domain; Region: HemN_C; pfam06969
246198003457	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
246198003458	elongation factor G; Reviewed; Region: PRK12740
246198003459	G1 box; other site
246198003460	putative GEF interaction site [polypeptide binding]; other site
246198003461	GTP/Mg2+ binding site [chemical binding]; other site
246198003462	Switch I region; other site
246198003463	G2 box; other site
246198003464	G3 box; other site
246198003465	Switch II region; other site
246198003466	G4 box; other site
246198003467	G5 box; other site
246198003468	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
246198003469	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
246198003470	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
246198003471	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
246198003472	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
246198003473	Ligand binding site; other site
246198003474	Putative Catalytic site; other site
246198003475	DXD motif; other site
246198003476	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
246198003477	uracil-xanthine permease; Region: ncs2; TIGR00801
246198003478	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
246198003479	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
246198003480	ABC-ATPase subunit  interface; other site
246198003481	dimer interface [polypeptide binding]; other site
246198003482	putative PBP binding regions; other site
246198003483	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
246198003484	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
246198003485	intersubunit interface [polypeptide binding]; other site
246198003486	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
246198003487	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
246198003488	transmembrane helices; other site
246198003489	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
246198003490	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
246198003491	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
246198003492	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
246198003493	putative NADH binding site [chemical binding]; other site
246198003494	putative active site [active]
246198003495	nudix motif; other site
246198003496	putative metal binding site [ion binding]; other site
246198003497	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
246198003498	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
246198003499	active site
246198003500	metal binding site [ion binding]; metal-binding site
246198003501	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
246198003502	UDP-glucose 4-epimerase; Region: PLN02240
246198003503	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
246198003504	NAD binding site [chemical binding]; other site
246198003505	homodimer interface [polypeptide binding]; other site
246198003506	active site
246198003507	substrate binding site [chemical binding]; other site
246198003508	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
246198003509	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
246198003510	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466
246198003511	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198003512	FeS/SAM binding site; other site
246198003513	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
246198003514	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
246198003515	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
246198003516	MULE transposase domain; Region: MULE; pfam10551
246198003517	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198003518	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198003519	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
246198003520	Catalytic site [active]
246198003521	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
246198003522	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198003523	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
246198003524	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198003525	DNA binding residues [nucleotide binding]
246198003526	GldH lipoprotein; Region: GldH_lipo; pfam14109
246198003527	PSP1 C-terminal conserved region; Region: PSP1; cl00770
246198003528	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
246198003529	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
246198003530	DNA polymerase III subunit delta'; Validated; Region: PRK08485
246198003531	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198003532	active site
246198003533	DNA binding site [nucleotide binding]
246198003534	Int/Topo IB signature motif; other site
246198003535	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
246198003536	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
246198003537	Protein export membrane protein; Region: SecD_SecF; cl14618
246198003538	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
246198003539	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198003540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198003541	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
246198003542	Walker A/P-loop; other site
246198003543	ATP binding site [chemical binding]; other site
246198003544	Q-loop/lid; other site
246198003545	ABC transporter signature motif; other site
246198003546	Walker B; other site
246198003547	D-loop; other site
246198003548	H-loop/switch region; other site
246198003549	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246198003550	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246198003551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198003552	Walker A/P-loop; other site
246198003553	ATP binding site [chemical binding]; other site
246198003554	Q-loop/lid; other site
246198003555	ABC transporter signature motif; other site
246198003556	Walker B; other site
246198003557	D-loop; other site
246198003558	H-loop/switch region; other site
246198003559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246198003560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246198003561	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198003562	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198003563	Virulence-associated protein E; Region: VirE; pfam05272
246198003564	Toprim-like; Region: Toprim_2; pfam13155
246198003565	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198003566	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198003567	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
246198003568	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198003569	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198003570	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198003571	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198003572	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
246198003573	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198003574	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
246198003575	L11 interface [polypeptide binding]; other site
246198003576	putative EF-Tu interaction site [polypeptide binding]; other site
246198003577	putative EF-G interaction site [polypeptide binding]; other site
246198003578	Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675
246198003579	DEAD-like helicases superfamily; Region: DEXDc; smart00487
246198003580	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
246198003581	ATP binding site [chemical binding]; other site
246198003582	Mg++ binding site [ion binding]; other site
246198003583	motif III; other site
246198003584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198003585	nucleotide binding region [chemical binding]; other site
246198003586	ATP-binding site [chemical binding]; other site
246198003587	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
246198003588	RNA binding site [nucleotide binding]; other site
246198003589	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
246198003590	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
246198003591	thymidine kinase; Provisional; Region: PRK04296
246198003592	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
246198003593	Uncharacterized conserved protein [Function unknown]; Region: COG3391
246198003594	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
246198003595	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
246198003596	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198003597	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
246198003598	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
246198003599	Coenzyme A binding pocket [chemical binding]; other site
246198003600	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
246198003601	active site
246198003602	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
246198003603	substrate binding site [chemical binding]; other site
246198003604	metal binding site [ion binding]; metal-binding site
246198003605	Uncharacterized conserved protein [Function unknown]; Region: COG1739
246198003606	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
246198003607	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
246198003608	Uncharacterized conserved protein [Function unknown]; Region: COG4198
246198003609	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
246198003610	putative ligand binding site [chemical binding]; other site
246198003611	putative NAD binding site [chemical binding]; other site
246198003612	putative catalytic site [active]
246198003613	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
246198003614	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246198003615	catalytic residue [active]
246198003616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
246198003617	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
246198003618	ATP binding site [chemical binding]; other site
246198003619	putative Mg++ binding site [ion binding]; other site
246198003620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198003621	nucleotide binding region [chemical binding]; other site
246198003622	ATP-binding site [chemical binding]; other site
246198003623	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
246198003624	RNA binding site [nucleotide binding]; other site
246198003625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198003626	binding surface
246198003627	TPR motif; other site
246198003628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198003629	TPR repeat; Region: TPR_11; pfam13414
246198003630	binding surface
246198003631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246198003632	binding surface
246198003633	TPR motif; other site
246198003634	DNA gyrase subunit A; Validated; Region: PRK05560
246198003635	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
246198003636	CAP-like domain; other site
246198003637	active site
246198003638	primary dimer interface [polypeptide binding]; other site
246198003639	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246198003640	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246198003641	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246198003642	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246198003643	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246198003644	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246198003645	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
246198003646	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
246198003647	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
246198003648	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
246198003649	muropeptide transporter; Validated; Region: ampG; cl17669
246198003650	Major Facilitator Superfamily; Region: MFS_1; pfam07690
246198003651	Stage II sporulation protein; Region: SpoIID; pfam08486
246198003652	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
246198003653	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
246198003654	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
246198003655	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
246198003656	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
246198003657	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
246198003658	catalytic residue [active]
246198003659	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
246198003660	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
246198003661	FtsX-like permease family; Region: FtsX; pfam02687
246198003662	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
246198003663	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
246198003664	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
246198003665	acyl-activating enzyme (AAE) consensus motif; other site
246198003666	acyl-activating enzyme (AAE) consensus motif; other site
246198003667	putative AMP binding site [chemical binding]; other site
246198003668	putative active site [active]
246198003669	putative CoA binding site [chemical binding]; other site
246198003670	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
246198003671	Competence protein; Region: Competence; pfam03772
246198003672	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
246198003673	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
246198003674	dimerization interface 3.5A [polypeptide binding]; other site
246198003675	active site
246198003676	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
246198003677	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
246198003678	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
246198003679	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
246198003680	active site
246198003681	catalytic site [active]
246198003682	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
246198003683	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
246198003684	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
246198003685	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
246198003686	ZIP Zinc transporter; Region: Zip; pfam02535
246198003687	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
246198003688	hypothetical protein; Provisional; Region: PRK10279
246198003689	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
246198003690	active site
246198003691	nucleophile elbow; other site
246198003692	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
246198003693	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198003694	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
246198003695	active site
246198003696	motif I; other site
246198003697	motif II; other site
246198003698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198003699	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198003700	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198003701	Spi protease inhibitor; Region: Inhibitor_I69; pfam13734
246198003702	Peptidase C10 family; Region: Peptidase_C10; pfam01640
246198003703	Ferredoxin [Energy production and conversion]; Region: COG1146
246198003704	4Fe-4S binding domain; Region: Fer4; pfam00037
246198003705	M6 family metalloprotease domain; Region: M6dom_TIGR03296
246198003706	Fn3 associated; Region: Fn3_assoc; pfam13287
246198003707	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
246198003708	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
246198003709	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
246198003710	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
246198003711	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
246198003712	N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795
246198003713	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
246198003714	putative active site [active]
246198003715	catalytic site [active]
246198003716	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
246198003717	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
246198003718	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
246198003719	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
246198003720	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
246198003721	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
246198003722	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
246198003723	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
246198003724	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
246198003725	GMP synthase; Reviewed; Region: guaA; PRK00074
246198003726	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
246198003727	AMP/PPi binding site [chemical binding]; other site
246198003728	candidate oxyanion hole; other site
246198003729	catalytic triad [active]
246198003730	potential glutamine specificity residues [chemical binding]; other site
246198003731	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
246198003732	ATP Binding subdomain [chemical binding]; other site
246198003733	Ligand Binding sites [chemical binding]; other site
246198003734	Dimerization subdomain; other site
246198003735	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
246198003736	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
246198003737	Substrate binding site; other site
246198003738	metal-binding site
246198003739	Phosphotransferase enzyme family; Region: APH; pfam01636
246198003740	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
246198003741	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
246198003742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198003743	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
246198003744	Walker A motif; other site
246198003745	ATP binding site [chemical binding]; other site
246198003746	Walker B motif; other site
246198003747	arginine finger; other site
246198003748	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
246198003749	Lipopolysaccharide-assembly; Region: LptE; pfam04390
246198003750	Preprotein translocase SecG subunit; Region: SecG; pfam03840
246198003751	probable metal-binding protein; Region: matur_matur; TIGR03853
246198003752	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
246198003753	recombination protein F; Reviewed; Region: recF; PRK00064
246198003754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198003755	Walker A/P-loop; other site
246198003756	ATP binding site [chemical binding]; other site
246198003757	Q-loop/lid; other site
246198003758	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198003759	ABC transporter signature motif; other site
246198003760	Walker B; other site
246198003761	D-loop; other site
246198003762	H-loop/switch region; other site
246198003763	Protein of unknown function (DUF721); Region: DUF721; pfam05258
246198003764	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198003765	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
246198003766	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
246198003767	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246198003768	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
246198003769	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
246198003770	protein binding site [polypeptide binding]; other site
246198003771	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
246198003772	Catalytic dyad [active]
246198003773	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
246198003774	catalytic motif [active]
246198003775	Zn binding site [ion binding]; other site
246198003776	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
246198003777	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
246198003778	active site
246198003779	Zn binding site [ion binding]; other site
246198003780	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
246198003781	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
246198003782	ligand binding site [chemical binding]; other site
246198003783	flexible hinge region; other site
246198003784	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
246198003785	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
246198003786	ApbE family; Region: ApbE; pfam02424
246198003787	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246198003788	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
246198003789	Ligand binding site; other site
246198003790	Putative Catalytic site; other site
246198003791	DXD motif; other site
246198003792	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
246198003793	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
246198003794	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
246198003795	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
246198003796	Probable Catalytic site; other site
246198003797	metal-binding site
246198003798	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
246198003799	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
246198003800	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
246198003801	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
246198003802	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
246198003803	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
246198003804	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
246198003805	ATP-grasp domain; Region: ATP-grasp_4; cl17255
246198003806	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
246198003807	probable substrate binding site [chemical binding]; other site
246198003808	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
246198003809	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
246198003810	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
246198003811	catalytic site [active]
246198003812	subunit interface [polypeptide binding]; other site
246198003813	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
246198003814	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
246198003815	active site
246198003816	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198003817	active site
246198003818	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
246198003819	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
246198003820	glutaminase active site [active]
246198003821	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
246198003822	dimer interface [polypeptide binding]; other site
246198003823	active site
246198003824	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
246198003825	dimer interface [polypeptide binding]; other site
246198003826	active site
246198003827	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
246198003828	SLBB domain; Region: SLBB; pfam10531
246198003829	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
246198003830	active site
246198003831	homodimer interface [polypeptide binding]; other site
246198003832	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
246198003833	dihydrodipicolinate synthase; Region: dapA; TIGR00674
246198003834	dimer interface [polypeptide binding]; other site
246198003835	active site
246198003836	catalytic residue [active]
246198003837	Sulfatase; Region: Sulfatase; cl17466
246198003838	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
246198003839	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
246198003840	generic binding surface II; other site
246198003841	generic binding surface I; other site
246198003842	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
246198003843	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
246198003844	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
246198003845	homodimer interface [polypeptide binding]; other site
246198003846	substrate-cofactor binding pocket; other site
246198003847	catalytic residue [active]
246198003848	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
246198003849	EamA-like transporter family; Region: EamA; pfam00892
246198003850	EamA-like transporter family; Region: EamA; pfam00892
246198003851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
246198003852	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
246198003853	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
246198003854	cation binding site [ion binding]; other site
246198003855	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
246198003856	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
246198003857	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
246198003858	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
246198003859	hypothetical protein; Provisional; Region: PRK07101
246198003860	substrate-cofactor binding pocket; other site
246198003861	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198003862	homodimer interface [polypeptide binding]; other site
246198003863	catalytic residue [active]
246198003864	para-aminobenzoate synthase component I; Validated; Region: PRK07093
246198003865	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
246198003866	pyruvate kinase; Provisional; Region: PRK05826
246198003867	domain interfaces; other site
246198003868	active site
246198003869	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
246198003870	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
246198003871	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
246198003872	TPP-binding site [chemical binding]; other site
246198003873	dimer interface [polypeptide binding]; other site
246198003874	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
246198003875	PYR/PP interface [polypeptide binding]; other site
246198003876	dimer interface [polypeptide binding]; other site
246198003877	TPP binding site [chemical binding]; other site
246198003878	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
246198003879	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
246198003880	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
246198003881	active site
246198003882	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246198003883	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246198003884	ligand binding site [chemical binding]; other site
246198003885	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
246198003886	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
246198003887	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
246198003888	TPP-binding site [chemical binding]; other site
246198003889	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
246198003890	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
246198003891	dimer interface [polypeptide binding]; other site
246198003892	PYR/PP interface [polypeptide binding]; other site
246198003893	TPP binding site [chemical binding]; other site
246198003894	substrate binding site [chemical binding]; other site
246198003895	TPR repeat; Region: TPR_11; pfam13414
246198003896	Tetratricopeptide repeats; Region: TPR; smart00028
246198003897	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
246198003898	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
246198003899	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
246198003900	homodimer interface [polypeptide binding]; other site
246198003901	NADP binding site [chemical binding]; other site
246198003902	substrate binding site [chemical binding]; other site
246198003903	signal recognition particle protein; Provisional; Region: PRK10867
246198003904	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
246198003905	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
246198003906	P loop; other site
246198003907	GTP binding site [chemical binding]; other site
246198003908	Signal peptide binding domain; Region: SRP_SPB; pfam02978
246198003909	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
246198003910	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
246198003911	Domain of unknown function (DUF955); Region: DUF955; cl01076
246198003912	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
246198003913	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
246198003914	nucleotide binding pocket [chemical binding]; other site
246198003915	K-X-D-G motif; other site
246198003916	catalytic site [active]
246198003917	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
246198003918	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
246198003919	Dimer interface [polypeptide binding]; other site
246198003920	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
246198003921	B3/4 domain; Region: B3_4; pfam03483
246198003922	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
246198003923	active site
246198003924	8-oxo-dGMP binding site [chemical binding]; other site
246198003925	nudix motif; other site
246198003926	metal binding site [ion binding]; metal-binding site
246198003927	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
246198003928	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
246198003929	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
246198003930	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
246198003931	substrate binding site [chemical binding]; other site
246198003932	tetramer interface [polypeptide binding]; other site
246198003933	catalytic residue [active]
246198003934	Predicted membrane protein [Function unknown]; Region: COG2860
246198003935	UPF0126 domain; Region: UPF0126; pfam03458
246198003936	UPF0126 domain; Region: UPF0126; pfam03458
246198003937	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
246198003938	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
246198003939	putative ligand binding site [chemical binding]; other site
246198003940	putative NAD binding site [chemical binding]; other site
246198003941	catalytic site [active]
246198003942	recombination factor protein RarA; Reviewed; Region: PRK13342
246198003943	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198003944	Walker A motif; other site
246198003945	ATP binding site [chemical binding]; other site
246198003946	Walker B motif; other site
246198003947	arginine finger; other site
246198003948	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
246198003949	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
246198003950	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198003951	motif II; other site
246198003952	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
246198003953	hypothetical protein; Provisional; Region: PRK00955
246198003954	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
246198003955	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
246198003956	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
246198003957	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
246198003958	Interdomain contacts; other site
246198003959	Cytokine receptor motif; other site
246198003960	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
246198003961	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
246198003962	putative acyl-acceptor binding pocket; other site
246198003963	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085
246198003964	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
246198003965	active site
246198003966	ADP/pyrophosphate binding site [chemical binding]; other site
246198003967	dimerization interface [polypeptide binding]; other site
246198003968	allosteric effector site; other site
246198003969	fructose-1,6-bisphosphate binding site; other site
246198003970	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
246198003971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198003972	S-adenosylmethionine binding site [chemical binding]; other site
246198003973	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
246198003974	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
246198003975	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
246198003976	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
246198003977	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
246198003978	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
246198003979	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
246198003980	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
246198003981	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
246198003982	Peptidase family U32; Region: Peptidase_U32; pfam01136
246198003983	Collagenase; Region: DUF3656; pfam12392
246198003984	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
246198003985	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198003986	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198003987	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
246198003988	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
246198003989	homodimer interface [polypeptide binding]; other site
246198003990	oligonucleotide binding site [chemical binding]; other site
246198003991	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246198003992	IHF - DNA interface [nucleotide binding]; other site
246198003993	IHF dimer interface [polypeptide binding]; other site
246198003994	pantothenate kinase; Provisional; Region: PRK13317
246198003995	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
246198003996	Na binding site [ion binding]; other site
246198003997	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
246198003998	catalytic residues [active]
246198003999	dimer interface [polypeptide binding]; other site
246198004000	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
246198004001	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
246198004002	putative catalytic site [active]
246198004003	putative metal binding site [ion binding]; other site
246198004004	putative phosphate binding site [ion binding]; other site
246198004005	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
246198004006	putative active site [active]
246198004007	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
246198004008	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
246198004009	Sugar specificity; other site
246198004010	Pyrimidine base specificity; other site
246198004011	ATP-binding site [chemical binding]; other site
246198004012	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
246198004013	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
246198004014	catalytic core [active]
246198004015	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
246198004016	active site
246198004017	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
246198004018	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
246198004019	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
246198004020	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
246198004021	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
246198004022	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
246198004023	lipoyl attachment site [posttranslational modification]; other site
246198004024	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
246198004025	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
246198004026	tetramer interface [polypeptide binding]; other site
246198004027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198004028	catalytic residue [active]
246198004029	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
246198004030	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246198004031	catalytic residue [active]
246198004032	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
246198004033	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246198004034	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
246198004035	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
246198004036	Lumazine binding domain; Region: Lum_binding; pfam00677
246198004037	Lumazine binding domain; Region: Lum_binding; pfam00677
246198004038	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246198004039	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246198004040	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
246198004041	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
246198004042	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198004043	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
246198004044	N-terminal plug; other site
246198004045	ligand-binding site [chemical binding]; other site
246198004046	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
246198004047	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
246198004048	dimer interface [polypeptide binding]; other site
246198004049	anticodon binding site; other site
246198004050	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
246198004051	homodimer interface [polypeptide binding]; other site
246198004052	motif 1; other site
246198004053	active site
246198004054	motif 2; other site
246198004055	GAD domain; Region: GAD; pfam02938
246198004056	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
246198004057	motif 3; other site
246198004058	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
246198004059	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
246198004060	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
246198004061	Substrate binding site; other site
246198004062	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
246198004063	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
246198004064	NADP-binding site; other site
246198004065	homotetramer interface [polypeptide binding]; other site
246198004066	substrate binding site [chemical binding]; other site
246198004067	homodimer interface [polypeptide binding]; other site
246198004068	active site
246198004069	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
246198004070	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198004071	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198004072	DNA binding residues [nucleotide binding]
246198004073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198004074	TPR motif; other site
246198004075	binding surface
246198004076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198004077	binding surface
246198004078	TPR motif; other site
246198004079	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
246198004080	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198004081	active site
246198004082	HIGH motif; other site
246198004083	nucleotide binding site [chemical binding]; other site
246198004084	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198004085	active site
246198004086	KMSKS motif; other site
246198004087	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
246198004088	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
246198004089	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
246198004090	Predicted membrane protein [Function unknown]; Region: COG2261
246198004091	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
246198004092	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
246198004093	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
246198004094	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
246198004095	Uncharacterized conserved protein [Function unknown]; Region: COG3189
246198004096	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
246198004097	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
246198004098	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
246198004099	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
246198004100	ResB-like family; Region: ResB; pfam05140
246198004101	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
246198004102	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
246198004103	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
246198004104	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
246198004105	hybrid cluster protein; Provisional; Region: PRK05290
246198004106	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
246198004107	ACS interaction site; other site
246198004108	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
246198004109	hybrid metal cluster; other site
246198004110	Methyltransferase domain; Region: Methyltransf_31; pfam13847
246198004111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198004112	S-adenosylmethionine binding site [chemical binding]; other site
246198004113	Nitroreductase family; Region: Nitroreductase; pfam00881
246198004114	FMN binding site [chemical binding]; other site
246198004115	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
246198004116	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
246198004117	trmE is a tRNA modification GTPase; Region: trmE; cd04164
246198004118	G1 box; other site
246198004119	GTP/Mg2+ binding site [chemical binding]; other site
246198004120	Switch I region; other site
246198004121	G2 box; other site
246198004122	Switch II region; other site
246198004123	G3 box; other site
246198004124	G4 box; other site
246198004125	G5 box; other site
246198004126	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
246198004127	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
246198004128	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
246198004129	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
246198004130	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
246198004131	FAD binding pocket [chemical binding]; other site
246198004132	FAD binding motif [chemical binding]; other site
246198004133	phosphate binding motif [ion binding]; other site
246198004134	beta-alpha-beta structure motif; other site
246198004135	NAD binding pocket [chemical binding]; other site
246198004136	Iron coordination center [ion binding]; other site
246198004137	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
246198004138	seryl-tRNA synthetase; Provisional; Region: PRK05431
246198004139	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
246198004140	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
246198004141	dimer interface [polypeptide binding]; other site
246198004142	active site
246198004143	motif 1; other site
246198004144	motif 2; other site
246198004145	motif 3; other site
246198004146	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
246198004147	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
246198004148	carboxyltransferase (CT) interaction site; other site
246198004149	biotinylation site [posttranslational modification]; other site
246198004150	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
246198004151	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
246198004152	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
246198004153	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
246198004154	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
246198004155	ATP binding site [chemical binding]; other site
246198004156	Mg++ binding site [ion binding]; other site
246198004157	motif III; other site
246198004158	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198004159	nucleotide binding region [chemical binding]; other site
246198004160	ATP-binding site [chemical binding]; other site
246198004161	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
246198004162	Predicted permeases [General function prediction only]; Region: COG0795
246198004163	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
246198004164	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
246198004165	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
246198004166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198004167	Walker A motif; other site
246198004168	ATP binding site [chemical binding]; other site
246198004169	Walker B motif; other site
246198004170	arginine finger; other site
246198004171	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
246198004172	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
246198004173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198004174	S-adenosylmethionine binding site [chemical binding]; other site
246198004175	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
246198004176	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
246198004177	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
246198004178	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
246198004179	substrate-cofactor binding pocket; other site
246198004180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198004181	catalytic residue [active]
246198004182	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
246198004183	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
246198004184	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
246198004185	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
246198004186	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
246198004187	nucleoside/Zn binding site; other site
246198004188	dimer interface [polypeptide binding]; other site
246198004189	catalytic motif [active]
246198004190	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
246198004191	Zn2+ binding site [ion binding]; other site
246198004192	Mg2+ binding site [ion binding]; other site
246198004193	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
246198004194	UbiA prenyltransferase family; Region: UbiA; pfam01040
246198004195	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
246198004196	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
246198004197	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
246198004198	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
246198004199	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246198004200	active site
246198004201	aspartate kinase III; Validated; Region: PRK09084
246198004202	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
246198004203	putative catalytic residues [active]
246198004204	nucleotide binding site [chemical binding]; other site
246198004205	aspartate binding site [chemical binding]; other site
246198004206	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
246198004207	dimer interface [polypeptide binding]; other site
246198004208	allosteric regulatory binding pocket; other site
246198004209	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
246198004210	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
246198004211	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198004212	Walker A/P-loop; other site
246198004213	ATP binding site [chemical binding]; other site
246198004214	Q-loop/lid; other site
246198004215	ABC transporter signature motif; other site
246198004216	Walker B; other site
246198004217	D-loop; other site
246198004218	H-loop/switch region; other site
246198004219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
246198004220	DNA Polymerase alpha zinc finger; Region: zf-DNA_Pol; pfam08996
246198004221	FHA domain; Region: FHA; pfam00498
246198004222	phosphopeptide binding site; other site
246198004223	Sporulation related domain; Region: SPOR; cl10051
246198004224	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
246198004225	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192
246198004226	Outer membrane lipoprotein; Region: YfiO; pfam13525
246198004227	excinuclease ABC subunit B; Provisional; Region: PRK05298
246198004228	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198004229	ATP binding site [chemical binding]; other site
246198004230	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198004231	nucleotide binding region [chemical binding]; other site
246198004232	ATP-binding site [chemical binding]; other site
246198004233	Ultra-violet resistance protein B; Region: UvrB; pfam12344
246198004234	UvrB/uvrC motif; Region: UVR; pfam02151
246198004235	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
246198004236	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
246198004237	folate binding site [chemical binding]; other site
246198004238	NADP+ binding site [chemical binding]; other site
246198004239	thymidylate synthase; Reviewed; Region: thyA; PRK01827
246198004240	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
246198004241	dimerization interface [polypeptide binding]; other site
246198004242	active site
246198004243	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
246198004244	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
246198004245	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
246198004246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198004247	binding surface
246198004248	TPR motif; other site
246198004249	TPR repeat; Region: TPR_11; pfam13414
246198004250	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
246198004251	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246198004252	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246198004253	ligand binding site [chemical binding]; other site
246198004254	DNA topoisomerase III; Provisional; Region: PRK07726
246198004255	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
246198004256	active site
246198004257	putative interdomain interaction site [polypeptide binding]; other site
246198004258	putative metal-binding site [ion binding]; other site
246198004259	putative nucleotide binding site [chemical binding]; other site
246198004260	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
246198004261	domain I; other site
246198004262	DNA binding groove [nucleotide binding]
246198004263	phosphate binding site [ion binding]; other site
246198004264	domain II; other site
246198004265	domain III; other site
246198004266	nucleotide binding site [chemical binding]; other site
246198004267	catalytic site [active]
246198004268	domain IV; other site
246198004269	pyruvate phosphate dikinase; Provisional; Region: PRK09279
246198004270	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
246198004271	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
246198004272	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
246198004273	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
246198004274	YtxH-like protein; Region: YtxH; cl02079
246198004275	Sporulation related domain; Region: SPOR; pfam05036
246198004276	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
246198004277	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
246198004278	active site
246198004279	catalytic residues [active]
246198004280	metal binding site [ion binding]; metal-binding site
246198004281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198004282	binding surface
246198004283	TPR repeat; Region: TPR_11; pfam13414
246198004284	TPR motif; other site
246198004285	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
246198004286	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
246198004287	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
246198004288	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
246198004289	active site
246198004290	dimer interface [polypeptide binding]; other site
246198004291	motif 1; other site
246198004292	motif 2; other site
246198004293	motif 3; other site
246198004294	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
246198004295	anticodon binding site; other site
246198004296	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198004297	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198004298	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198004299	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198004300	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
246198004301	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
246198004302	dimer interface [polypeptide binding]; other site
246198004303	PYR/PP interface [polypeptide binding]; other site
246198004304	TPP binding site [chemical binding]; other site
246198004305	substrate binding site [chemical binding]; other site
246198004306	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
246198004307	Domain of unknown function; Region: EKR; smart00890
246198004308	4Fe-4S binding domain; Region: Fer4_6; pfam12837
246198004309	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
246198004310	TPP-binding site [chemical binding]; other site
246198004311	dimer interface [polypeptide binding]; other site
246198004312	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
246198004313	AAA domain; Region: AAA_14; pfam13173
246198004314	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
246198004315	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
246198004316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198004317	S-adenosylmethionine binding site [chemical binding]; other site
246198004318	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
246198004319	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
246198004320	putative DNA binding site [nucleotide binding]; other site
246198004321	putative Zn2+ binding site [ion binding]; other site
246198004322	AsnC family; Region: AsnC_trans_reg; pfam01037
246198004323	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
246198004324	recombination protein RecR; Reviewed; Region: recR; PRK00076
246198004325	RecR protein; Region: RecR; pfam02132
246198004326	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
246198004327	putative active site [active]
246198004328	putative metal-binding site [ion binding]; other site
246198004329	tetramer interface [polypeptide binding]; other site
246198004330	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
246198004331	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
246198004332	Probable Catalytic site; other site
246198004333	metal-binding site
246198004334	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
246198004335	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
246198004336	Coenzyme A binding pocket [chemical binding]; other site
246198004337	Protein of unknown function (DUF328); Region: DUF328; pfam03883
246198004338	Low molecular weight phosphatase family; Region: LMWPc; cd00115
246198004339	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
246198004340	active site
246198004341	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
246198004342	active site residue [active]
246198004343	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
246198004344	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
246198004345	NADP binding site [chemical binding]; other site
246198004346	active site
246198004347	putative substrate binding site [chemical binding]; other site
246198004348	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
246198004349	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
246198004350	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
246198004351	active site
246198004352	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
246198004353	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
246198004354	Ligand binding site; other site
246198004355	metal-binding site
246198004356	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198004357	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198004358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
246198004359	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
246198004360	putative ADP-binding pocket [chemical binding]; other site
246198004361	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
246198004362	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246198004363	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
246198004364	active site
246198004365	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
246198004366	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
246198004367	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
246198004368	putative ADP-binding pocket [chemical binding]; other site
246198004369	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
246198004370	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
246198004371	putative ADP-binding pocket [chemical binding]; other site
246198004372	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
246198004373	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
246198004374	Bacterial sugar transferase; Region: Bac_transf; pfam02397
246198004375	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
246198004376	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
246198004377	inhibitor-cofactor binding pocket; inhibition site
246198004378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198004379	catalytic residue [active]
246198004380	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
246198004381	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
246198004382	putative active site [active]
246198004383	substrate binding site [chemical binding]; other site
246198004384	putative cosubstrate binding site; other site
246198004385	catalytic site [active]
246198004386	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
246198004387	substrate binding site [chemical binding]; other site
246198004388	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
246198004389	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
246198004390	Cl- selectivity filter; other site
246198004391	Cl- binding residues [ion binding]; other site
246198004392	pore gating glutamate residue; other site
246198004393	dimer interface [polypeptide binding]; other site
246198004394	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
246198004395	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
246198004396	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
246198004397	L-fucose transporter; Provisional; Region: PRK10133; cl17665
246198004398	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
246198004399	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246198004400	chaperone protein DnaJ; Provisional; Region: PRK14289
246198004401	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
246198004402	HSP70 interaction site [polypeptide binding]; other site
246198004403	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
246198004404	substrate binding site [polypeptide binding]; other site
246198004405	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
246198004406	Zn binding sites [ion binding]; other site
246198004407	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
246198004408	dimer interface [polypeptide binding]; other site
246198004409	GrpE; Region: GrpE; pfam01025
246198004410	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
246198004411	dimer interface [polypeptide binding]; other site
246198004412	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
246198004413	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
246198004414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246198004415	Walker A/P-loop; other site
246198004416	ATP binding site [chemical binding]; other site
246198004417	Q-loop/lid; other site
246198004418	ABC transporter signature motif; other site
246198004419	Walker B; other site
246198004420	D-loop; other site
246198004421	H-loop/switch region; other site
246198004422	ABC transporter; Region: ABC_tran_2; pfam12848
246198004423	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198004424	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
246198004425	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
246198004426	active site
246198004427	Zn binding site [ion binding]; other site
246198004428	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
246198004429	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198004430	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198004431	ABC transporter; Region: ABC_tran_2; pfam12848
246198004432	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246198004433	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
246198004434	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
246198004435	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246198004436	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
246198004437	RNA binding site [nucleotide binding]; other site
246198004438	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
246198004439	23S rRNA binding site [nucleotide binding]; other site
246198004440	L21 binding site [polypeptide binding]; other site
246198004441	L13 binding site [polypeptide binding]; other site
246198004442	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
246198004443	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
246198004444	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
246198004445	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
246198004446	AAA domain; Region: AAA_28; pfam13521
246198004447	NTPase; Region: NTPase_1; cl17478
246198004448	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
246198004449	putative active site; other site
246198004450	putative metal binding residues [ion binding]; other site
246198004451	signature motif; other site
246198004452	putative triphosphate binding site [ion binding]; other site
246198004453	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
246198004454	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
246198004455	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
246198004456	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
246198004457	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
246198004458	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
246198004459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198004460	active site
246198004461	phosphorylation site [posttranslational modification]
246198004462	intermolecular recognition site; other site
246198004463	dimerization interface [polypeptide binding]; other site
246198004464	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
246198004465	DNA binding site [nucleotide binding]
246198004466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
246198004467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246198004468	dimer interface [polypeptide binding]; other site
246198004469	phosphorylation site [posttranslational modification]
246198004470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198004471	ATP binding site [chemical binding]; other site
246198004472	Mg2+ binding site [ion binding]; other site
246198004473	G-X-G motif; other site
246198004474	YceG-like family; Region: YceG; pfam02618
246198004475	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
246198004476	dimerization interface [polypeptide binding]; other site
246198004477	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
246198004478	MORN repeat; Region: MORN; cl14787
246198004479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
246198004480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
246198004481	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
246198004482	Domain of unknown function DUF21; Region: DUF21; pfam01595
246198004483	gliding motility-associated protein GldE; Region: GldE; TIGR03520
246198004484	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
246198004485	Transporter associated domain; Region: CorC_HlyC; smart01091
246198004486	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
246198004487	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
246198004488	dimer interface [polypeptide binding]; other site
246198004489	ssDNA binding site [nucleotide binding]; other site
246198004490	tetramer (dimer of dimers) interface [polypeptide binding]; other site
246198004491	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
246198004492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
246198004493	active site
246198004494	phosphorylation site [posttranslational modification]
246198004495	intermolecular recognition site; other site
246198004496	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
246198004497	DNA binding site [nucleotide binding]
246198004498	domain linker motif; other site
246198004499	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
246198004500	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
246198004501	ligand binding site [chemical binding]; other site
246198004502	TIGR02453 family protein; Region: TIGR02453
246198004503	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
246198004504	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
246198004505	minor groove reading motif; other site
246198004506	helix-hairpin-helix signature motif; other site
246198004507	substrate binding pocket [chemical binding]; other site
246198004508	active site
246198004509	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
246198004510	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
246198004511	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
246198004512	dimer interface [polypeptide binding]; other site
246198004513	motif 1; other site
246198004514	active site
246198004515	motif 2; other site
246198004516	motif 3; other site
246198004517	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
246198004518	anticodon binding site; other site
246198004519	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
246198004520	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
246198004521	GDP-binding site [chemical binding]; other site
246198004522	ACT binding site; other site
246198004523	IMP binding site; other site
246198004524	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
246198004525	metal binding site 2 [ion binding]; metal-binding site
246198004526	putative DNA binding helix; other site
246198004527	metal binding site 1 [ion binding]; metal-binding site
246198004528	dimer interface [polypeptide binding]; other site
246198004529	structural Zn2+ binding site [ion binding]; other site
246198004530	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198004531	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198004532	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198004533	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198004534	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246198004535	Active site serine [active]
246198004536	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
246198004537	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
246198004538	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
246198004539	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
246198004540	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198004541	active site
246198004542	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
246198004543	active site
246198004544	thiamine phosphate binding site [chemical binding]; other site
246198004545	pyrophosphate binding site [ion binding]; other site
246198004546	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
246198004547	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
246198004548	active site
246198004549	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
246198004550	dimer interface [polypeptide binding]; other site
246198004551	catalytic residues [active]
246198004552	substrate binding site [chemical binding]; other site
246198004553	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
246198004554	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
246198004555	HSP70 interaction site [polypeptide binding]; other site
246198004556	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
246198004557	dimer interface [polypeptide binding]; other site
246198004558	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
246198004559	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
246198004560	RNA binding surface [nucleotide binding]; other site
246198004561	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246198004562	active site
246198004563	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
246198004564	active site
246198004565	substrate binding site [chemical binding]; other site
246198004566	trimer interface [polypeptide binding]; other site
246198004567	CoA binding site [chemical binding]; other site
246198004568	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
246198004569	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
246198004570	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
246198004571	putative active site; other site
246198004572	catalytic triad [active]
246198004573	putative dimer interface [polypeptide binding]; other site
246198004574	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
246198004575	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
246198004576	Part of AAA domain; Region: AAA_19; pfam13245
246198004577	putative recombination protein RecB; Provisional; Region: PRK13909
246198004578	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
246198004579	Family description; Region: UvrD_C_2; pfam13538
246198004580	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
246198004581	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
246198004582	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
246198004583	Transglycosylase; Region: Transgly; cl17702
246198004584	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
246198004585	PhoH-like protein; Region: PhoH; pfam02562
246198004586	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
246198004587	ATP binding site [chemical binding]; other site
246198004588	active site
246198004589	substrate binding site [chemical binding]; other site
246198004590	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
246198004591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246198004592	S-adenosylmethionine binding site [chemical binding]; other site
246198004593	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
246198004594	dimerization interface [polypeptide binding]; other site
246198004595	ATP binding site [chemical binding]; other site
246198004596	peptide chain release factor 1; Validated; Region: prfA; PRK00591
246198004597	PCRF domain; Region: PCRF; pfam03462
246198004598	RF-1 domain; Region: RF-1; pfam00472
246198004599	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
246198004600	active site
246198004601	dimer interface [polypeptide binding]; other site
246198004602	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
246198004603	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
246198004604	Zn2+ binding site [ion binding]; other site
246198004605	Mg2+ binding site [ion binding]; other site
246198004606	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
246198004607	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
246198004608	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
246198004609	trimer interface [polypeptide binding]; other site
246198004610	active site
246198004611	UDP-GlcNAc binding site [chemical binding]; other site
246198004612	lipid binding site [chemical binding]; lipid-binding site
246198004613	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
246198004614	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
246198004615	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
246198004616	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
246198004617	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
246198004618	active site
246198004619	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
246198004620	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
246198004621	Transglycosylase; Region: Transgly; pfam00912
246198004622	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
246198004623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246198004624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198004625	binding surface
246198004626	TPR motif; other site
246198004627	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246198004628	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246198004629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198004630	TPR motif; other site
246198004631	binding surface
246198004632	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246198004633	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
246198004634	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246198004635	dimer interface [polypeptide binding]; other site
246198004636	phosphorylation site [posttranslational modification]
246198004637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246198004638	ATP binding site [chemical binding]; other site
246198004639	Mg2+ binding site [ion binding]; other site
246198004640	G-X-G motif; other site
246198004641	Response regulator receiver domain; Region: Response_reg; pfam00072
246198004642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198004643	active site
246198004644	phosphorylation site [posttranslational modification]
246198004645	intermolecular recognition site; other site
246198004646	dimerization interface [polypeptide binding]; other site
246198004647	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198004648	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198004649	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
246198004650	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
246198004651	PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2)  domain.  It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011
246198004652	ribonuclease Z; Region: RNase_Z; TIGR02651
246198004653	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
246198004654	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
246198004655	homodimer interface [polypeptide binding]; other site
246198004656	metal binding site [ion binding]; metal-binding site
246198004657	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
246198004658	homodimer interface [polypeptide binding]; other site
246198004659	active site
246198004660	putative chemical substrate binding site [chemical binding]; other site
246198004661	metal binding site [ion binding]; metal-binding site
246198004662	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
246198004663	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246198004664	active site
246198004665	HIGH motif; other site
246198004666	nucleotide binding site [chemical binding]; other site
246198004667	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
246198004668	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
246198004669	active site
246198004670	KMSKS motif; other site
246198004671	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
246198004672	tRNA binding surface [nucleotide binding]; other site
246198004673	anticodon binding site; other site
246198004674	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
246198004675	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
246198004676	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
246198004677	ring oligomerisation interface [polypeptide binding]; other site
246198004678	ATP/Mg binding site [chemical binding]; other site
246198004679	stacking interactions; other site
246198004680	hinge regions; other site
246198004681	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
246198004682	oligomerisation interface [polypeptide binding]; other site
246198004683	mobile loop; other site
246198004684	roof hairpin; other site
246198004685	DEAD-like helicases superfamily; Region: DEXDc; smart00487
246198004686	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198004687	ATP binding site [chemical binding]; other site
246198004688	putative Mg++ binding site [ion binding]; other site
246198004689	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198004690	nucleotide binding region [chemical binding]; other site
246198004691	ATP-binding site [chemical binding]; other site
246198004692	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
246198004693	DHH family; Region: DHH; pfam01368
246198004694	DHHA1 domain; Region: DHHA1; pfam02272
246198004695	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
246198004696	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
246198004697	proline aminopeptidase P II; Provisional; Region: PRK10879
246198004698	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
246198004699	active site
246198004700	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
246198004701	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
246198004702	active site
246198004703	nucleophile elbow; other site
246198004704	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
246198004705	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198004706	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004707	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004708	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004709	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004710	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198004711	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004712	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004713	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004714	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004715	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004716	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198004717	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004718	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004719	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004720	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198004721	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004722	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198004723	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
246198004724	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
246198004725	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198004726	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198004727	DNA binding residues [nucleotide binding]
246198004728	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198004729	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
246198004730	nucleotide binding site [chemical binding]; other site
246198004731	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
246198004732	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
246198004733	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
246198004734	NADP binding site [chemical binding]; other site
246198004735	active site
246198004736	putative substrate binding site [chemical binding]; other site
246198004737	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
246198004738	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
246198004739	G1 box; other site
246198004740	putative GEF interaction site [polypeptide binding]; other site
246198004741	GTP/Mg2+ binding site [chemical binding]; other site
246198004742	Switch I region; other site
246198004743	G2 box; other site
246198004744	G3 box; other site
246198004745	Switch II region; other site
246198004746	G4 box; other site
246198004747	G5 box; other site
246198004748	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
246198004749	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198004750	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198004751	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198004752	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198004753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
246198004754	Transposase; Region: DDE_Tnp_ISL3; pfam01610
246198004755	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
246198004756	A new structural DNA glycosylase; Region: AlkD_like; cl11434
246198004757	active site
246198004758	Peptidase family M49; Region: Peptidase_M49; pfam03571
246198004759	Helix-turn-helix domain; Region: HTH_18; pfam12833
246198004760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
246198004761	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
246198004762	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
246198004763	Glutamine amidotransferase class-I; Region: GATase; pfam00117
246198004764	glutamine binding [chemical binding]; other site
246198004765	catalytic triad [active]
246198004766	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
246198004767	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
246198004768	active site
246198004769	ribulose/triose binding site [chemical binding]; other site
246198004770	phosphate binding site [ion binding]; other site
246198004771	substrate (anthranilate) binding pocket [chemical binding]; other site
246198004772	product (indole) binding pocket [chemical binding]; other site
246198004773	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
246198004774	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
246198004775	substrate binding site [chemical binding]; other site
246198004776	hexamer interface [polypeptide binding]; other site
246198004777	metal binding site [ion binding]; metal-binding site
246198004778	RNA polymerase sigma factor; Provisional; Region: PRK12513
246198004779	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246198004780	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246198004781	DNA binding residues [nucleotide binding]
246198004782	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
246198004783	core domain interface [polypeptide binding]; other site
246198004784	delta subunit interface [polypeptide binding]; other site
246198004785	epsilon subunit interface [polypeptide binding]; other site
246198004786	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
246198004787	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
246198004788	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
246198004789	beta subunit interaction interface [polypeptide binding]; other site
246198004790	Walker A motif; other site
246198004791	ATP binding site [chemical binding]; other site
246198004792	Walker B motif; other site
246198004793	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
246198004794	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
246198004795	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
246198004796	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
246198004797	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
246198004798	ATP synthase subunit C; Region: ATP-synt_C; cl00466
246198004799	ATP synthase A chain; Region: ATP-synt_A; cl00413
246198004800	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
246198004801	gamma subunit interface [polypeptide binding]; other site
246198004802	LBP interface [polypeptide binding]; other site
246198004803	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
246198004804	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
246198004805	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
246198004806	alpha subunit interaction interface [polypeptide binding]; other site
246198004807	Walker A motif; other site
246198004808	ATP binding site [chemical binding]; other site
246198004809	Walker B motif; other site
246198004810	inhibitor binding site; inhibition site
246198004811	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
246198004812	6-phosphofructokinase; Provisional; Region: PRK03202
246198004813	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
246198004814	active site
246198004815	ADP/pyrophosphate binding site [chemical binding]; other site
246198004816	dimerization interface [polypeptide binding]; other site
246198004817	allosteric effector site; other site
246198004818	fructose-1,6-bisphosphate binding site; other site
246198004819	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198004820	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
246198004821	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198004822	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198004823	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
246198004824	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246198004825	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
246198004826	active site
246198004827	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
246198004828	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
246198004829	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
246198004830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
246198004831	active site
246198004832	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246198004833	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
246198004834	active site
246198004835	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
246198004836	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
246198004837	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198004838	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198004839	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
246198004840	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
246198004841	metal binding site [ion binding]; metal-binding site
246198004842	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
246198004843	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
246198004844	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
246198004845	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
246198004846	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
246198004847	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
246198004848	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
246198004849	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
246198004850	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
246198004851	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
246198004852	ligand binding site [chemical binding]; other site
246198004853	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
246198004854	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
246198004855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246198004856	putative substrate translocation pore; other site
246198004857	POT family; Region: PTR2; cl17359
246198004858	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
246198004859	Cupin domain; Region: Cupin_2; pfam07883
246198004860	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198004861	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198004862	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198004863	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198004864	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
246198004865	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198004866	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
246198004867	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198004868	RNA methyltransferase, RsmE family; Region: TIGR00046
246198004869	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
246198004870	UvrB/uvrC motif; Region: UVR; pfam02151
246198004871	nucleoside transporter; Region: 2A0110; TIGR00889
246198004872	Protein of unknown function (DUF3256); Region: DUF3256; pfam11644
246198004873	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
246198004874	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
246198004875	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
246198004876	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
246198004877	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
246198004878	active site
246198004879	metal binding site [ion binding]; metal-binding site
246198004880	homotetramer interface [polypeptide binding]; other site
246198004881	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
246198004882	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
246198004883	NAD binding site [chemical binding]; other site
246198004884	substrate binding site [chemical binding]; other site
246198004885	homodimer interface [polypeptide binding]; other site
246198004886	active site
246198004887	WxcM-like, C-terminal; Region: FdtA; pfam05523
246198004888	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
246198004889	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
246198004890	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
246198004891	inhibitor-cofactor binding pocket; inhibition site
246198004892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246198004893	catalytic residue [active]
246198004894	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
246198004895	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
246198004896	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
246198004897	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
246198004898	Cysteine-rich domain; Region: CCG; pfam02754
246198004899	Cysteine-rich domain; Region: CCG; pfam02754
246198004900	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
246198004901	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
246198004902	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
246198004903	phosphoserine phosphatase SerB; Region: serB; TIGR00338
246198004904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246198004905	motif II; other site
246198004906	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
246198004907	DNA polymerase IV; Validated; Region: PRK02406
246198004908	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
246198004909	active site
246198004910	DNA binding site [nucleotide binding]
246198004911	Bacterial sugar transferase; Region: Bac_transf; pfam02397
246198004912	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
246198004913	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
246198004914	SLBB domain; Region: SLBB; pfam10531
246198004915	SLBB domain; Region: SLBB; pfam10531
246198004916	SLBB domain; Region: SLBB; pfam10531
246198004917	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
246198004918	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
246198004919	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
246198004920	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
246198004921	putative ligand binding site [chemical binding]; other site
246198004922	putative catalytic site [active]
246198004923	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
246198004924	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
246198004925	active site
246198004926	homodimer interface [polypeptide binding]; other site
246198004927	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
246198004928	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
246198004929	metal-binding site
246198004930	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
246198004931	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
246198004932	Mg++ binding site [ion binding]; other site
246198004933	putative catalytic motif [active]
246198004934	substrate binding site [chemical binding]; other site
246198004935	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
246198004936	CTP synthetase; Validated; Region: pyrG; PRK05380
246198004937	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
246198004938	Catalytic site [active]
246198004939	active site
246198004940	UTP binding site [chemical binding]; other site
246198004941	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
246198004942	active site
246198004943	putative oxyanion hole; other site
246198004944	catalytic triad [active]
246198004945	membrane protein insertase; Provisional; Region: PRK01318
246198004946	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
246198004947	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
246198004948	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
246198004949	Major Facilitator Superfamily; Region: MFS_1; pfam07690
246198004950	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
246198004951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
246198004952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
246198004953	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
246198004954	dimerization interface [polypeptide binding]; other site
246198004955	enolase; Provisional; Region: eno; PRK00077
246198004956	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
246198004957	dimer interface [polypeptide binding]; other site
246198004958	metal binding site [ion binding]; metal-binding site
246198004959	substrate binding pocket [chemical binding]; other site
246198004960	peroxiredoxin; Region: AhpC; TIGR03137
246198004961	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
246198004962	dimer interface [polypeptide binding]; other site
246198004963	decamer (pentamer of dimers) interface [polypeptide binding]; other site
246198004964	catalytic triad [active]
246198004965	peroxidatic and resolving cysteines [active]
246198004966	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
246198004967	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
246198004968	catalytic residue [active]
246198004969	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
246198004970	catalytic residues [active]
246198004971	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
246198004972	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246198004973	thiamine-monophosphate kinase; Region: thiL; TIGR01379
246198004974	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
246198004975	ATP binding site [chemical binding]; other site
246198004976	dimerization interface [polypeptide binding]; other site
246198004977	purine nucleoside phosphorylase; Provisional; Region: PRK08202
246198004978	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
246198004979	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
246198004980	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
246198004981	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
246198004982	tandem repeat interface [polypeptide binding]; other site
246198004983	oligomer interface [polypeptide binding]; other site
246198004984	active site residues [active]
246198004985	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
246198004986	tandem repeat interface [polypeptide binding]; other site
246198004987	oligomer interface [polypeptide binding]; other site
246198004988	active site residues [active]
246198004989	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
246198004990	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
246198004991	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
246198004992	ligand binding site [chemical binding]; other site
246198004993	flexible hinge region; other site
246198004994	GTP-binding protein LepA; Provisional; Region: PRK05433
246198004995	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
246198004996	G1 box; other site
246198004997	putative GEF interaction site [polypeptide binding]; other site
246198004998	GTP/Mg2+ binding site [chemical binding]; other site
246198004999	Switch I region; other site
246198005000	G2 box; other site
246198005001	G3 box; other site
246198005002	Switch II region; other site
246198005003	G4 box; other site
246198005004	G5 box; other site
246198005005	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
246198005006	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
246198005007	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
246198005008	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
246198005009	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
246198005010	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
246198005011	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
246198005012	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
246198005013	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
246198005014	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
246198005015	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
246198005016	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
246198005017	putative active site [active]
246198005018	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
246198005019	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
246198005020	PLD-like domain; Region: PLDc_2; pfam13091
246198005021	putative active site [active]
246198005022	catalytic site [active]
246198005023	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
246198005024	PLD-like domain; Region: PLDc_2; pfam13091
246198005025	putative active site [active]
246198005026	catalytic site [active]
246198005027	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
246198005028	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
246198005029	DNA binding residues [nucleotide binding]
246198005030	dimerization interface [polypeptide binding]; other site
246198005031	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
246198005032	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
246198005033	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
246198005034	DNA binding residues [nucleotide binding]
246198005035	dimerization interface [polypeptide binding]; other site
246198005036	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
246198005037	active site
246198005038	catalytic residues [active]
246198005039	glutamate formiminotransferase; Region: FtcD; TIGR02024
246198005040	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
246198005041	Formiminotransferase domain; Region: FTCD; pfam02971
246198005042	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
246198005043	urocanate hydratase; Provisional; Region: PRK05414
246198005044	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
246198005045	active sites [active]
246198005046	tetramer interface [polypeptide binding]; other site
246198005047	imidazolonepropionase; Validated; Region: PRK09356
246198005048	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
246198005049	active site
246198005050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198005051	binding surface
246198005052	TPR motif; other site
246198005053	TPR repeat; Region: TPR_11; pfam13414
246198005054	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198005055	binding surface
246198005056	TPR motif; other site
246198005057	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
246198005058	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
246198005059	Chorismate mutase type II; Region: CM_2; smart00830
246198005060	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
246198005061	putative catalytic site [active]
246198005062	putative metal binding site [ion binding]; other site
246198005063	putative phosphate binding site [ion binding]; other site
246198005064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
246198005065	motif I; other site
246198005066	active site
246198005067	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
246198005068	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
246198005069	substrate binding site; other site
246198005070	tetramer interface; other site
246198005071	Cell division protein ZapA; Region: ZapA; pfam05164
246198005072	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
246198005073	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
246198005074	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
246198005075	Zn2+ binding site [ion binding]; other site
246198005076	Mg2+ binding site [ion binding]; other site
246198005077	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
246198005078	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
246198005079	metal-binding site [ion binding]
246198005080	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
246198005081	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
246198005082	Soluble P-type ATPase [General function prediction only]; Region: COG4087
246198005083	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
246198005084	metal-binding site [ion binding]
246198005085	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
246198005086	putative efflux protein, MATE family; Region: matE; TIGR00797
246198005087	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
246198005088	active site
246198005089	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
246198005090	homodimer interface [polypeptide binding]; other site
246198005091	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
246198005092	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
246198005093	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
246198005094	Peptidase family M48; Region: Peptidase_M48; pfam01435
246198005095	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
246198005096	flavodoxin FldA; Validated; Region: PRK09267
246198005097	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
246198005098	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
246198005099	dimerization interface [polypeptide binding]; other site
246198005100	active site
246198005101	quinolinate synthetase; Provisional; Region: PRK09375
246198005102	L-aspartate oxidase; Provisional; Region: PRK09077
246198005103	L-aspartate oxidase; Provisional; Region: PRK06175
246198005104	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
246198005105	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198005106	active site
246198005107	catalytic residues [active]
246198005108	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
246198005109	catalytic residues [active]
246198005110	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
246198005111	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
246198005112	LytB protein; Region: LYTB; cl00507
246198005113	MG2 domain; Region: A2M_N; pfam01835
246198005114	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
246198005115	Alpha-2-macroglobulin family; Region: A2M; pfam00207
246198005116	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
246198005117	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246198005118	Radical SAM superfamily; Region: Radical_SAM; pfam04055
246198005119	FeS/SAM binding site; other site
246198005120	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198005121	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
246198005122	Clp amino terminal domain; Region: Clp_N; pfam02861
246198005123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198005124	Walker A motif; other site
246198005125	ATP binding site [chemical binding]; other site
246198005126	Walker B motif; other site
246198005127	arginine finger; other site
246198005128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198005129	Walker A motif; other site
246198005130	ATP binding site [chemical binding]; other site
246198005131	Walker B motif; other site
246198005132	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
246198005133	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
246198005134	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
246198005135	homodimer interaction site [polypeptide binding]; other site
246198005136	cofactor binding site; other site
246198005137	OPT oligopeptide transporter protein; Region: OPT; pfam03169
246198005138	putative oligopeptide transporter, OPT family; Region: TIGR00733
246198005139	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198005140	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198005141	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
246198005142	Thiamine pyrophosphokinase; Region: TPK; cd07995
246198005143	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
246198005144	active site
246198005145	dimerization interface [polypeptide binding]; other site
246198005146	thiamine binding site [chemical binding]; other site
246198005147	DnaA N-terminal domain; Region: DnaA_N; pfam11638
246198005148	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
246198005149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246198005150	Walker A motif; other site
246198005151	ATP binding site [chemical binding]; other site
246198005152	Walker B motif; other site
246198005153	arginine finger; other site
246198005154	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
246198005155	DnaA box-binding interface [nucleotide binding]; other site
246198005156	mce related protein; Region: MCE; pfam02470
246198005157	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
246198005158	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
246198005159	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
246198005160	active site
246198005161	metal binding site [ion binding]; metal-binding site
246198005162	Dihydroneopterin aldolase; Region: FolB; pfam02152
246198005163	active site
246198005164	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
246198005165	dimer interface [polypeptide binding]; other site
246198005166	NADPH bind site [chemical binding]; other site
246198005167	FMN binding site [chemical binding]; other site
246198005168	fumarate hydratase; Provisional; Region: PRK15389
246198005169	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
246198005170	Fumarase C-terminus; Region: Fumerase_C; pfam05683
246198005171	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198005172	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
246198005173	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198005174	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
246198005175	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
246198005176	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
246198005177	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
246198005178	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
246198005179	HflX GTPase family; Region: HflX; cd01878
246198005180	G1 box; other site
246198005181	GTP/Mg2+ binding site [chemical binding]; other site
246198005182	Switch I region; other site
246198005183	G2 box; other site
246198005184	G3 box; other site
246198005185	Switch II region; other site
246198005186	G4 box; other site
246198005187	G5 box; other site
246198005188	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
246198005189	catalytic center binding site [active]
246198005190	ATP binding site [chemical binding]; other site
246198005191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198005192	binding surface
246198005193	TPR motif; other site
246198005194	TPR repeat; Region: TPR_11; pfam13414
246198005195	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
246198005196	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
246198005197	Sodium Bile acid symporter family; Region: SBF; cl17470
246198005198	short chain dehydrogenase; Provisional; Region: PRK06181
246198005199	classical (c) SDRs; Region: SDR_c; cd05233
246198005200	NAD(P) binding site [chemical binding]; other site
246198005201	active site
246198005202	acyl-CoA synthetase; Provisional; Region: PRK13383
246198005203	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
246198005204	active site
246198005205	CoA binding site [chemical binding]; other site
246198005206	AMP binding site [chemical binding]; other site
246198005207	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
246198005208	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
246198005209	N-terminal plug; other site
246198005210	ligand-binding site [chemical binding]; other site
246198005211	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246198005212	active site
246198005213	xanthine permease; Region: pbuX; TIGR03173
246198005214	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
246198005215	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
246198005216	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
246198005217	active site
246198005218	catalytic triad [active]
246198005219	oxyanion hole [active]
246198005220	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
246198005221	active site
246198005222	putative catalytic site [active]
246198005223	DNA binding site [nucleotide binding]
246198005224	putative phosphate binding site [ion binding]; other site
246198005225	metal binding site A [ion binding]; metal-binding site
246198005226	AP binding site [nucleotide binding]; other site
246198005227	metal binding site B [ion binding]; metal-binding site
246198005228	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
246198005229	homodecamer interface [polypeptide binding]; other site
246198005230	GTP cyclohydrolase I; Provisional; Region: PLN03044
246198005231	active site
246198005232	putative catalytic site residues [active]
246198005233	zinc binding site [ion binding]; other site
246198005234	GTP-CH-I/GFRP interaction surface; other site
246198005235	Sporulation related domain; Region: SPOR; cl10051
246198005236	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
246198005237	triosephosphate isomerase; Provisional; Region: PRK14565
246198005238	substrate binding site [chemical binding]; other site
246198005239	dimer interface [polypeptide binding]; other site
246198005240	catalytic triad [active]
246198005241	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
246198005242	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
246198005243	Acyltransferase family; Region: Acyl_transf_3; pfam01757
246198005244	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
246198005245	S-ribosylhomocysteinase; Provisional; Region: PRK02260
246198005246	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198005247	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005248	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005249	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005250	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198005251	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005252	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005253	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005254	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
246198005255	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005256	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005257	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
246198005258	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
246198005259	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
246198005260	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
246198005261	G1 box; other site
246198005262	putative GEF interaction site [polypeptide binding]; other site
246198005263	GTP/Mg2+ binding site [chemical binding]; other site
246198005264	Switch I region; other site
246198005265	G2 box; other site
246198005266	G3 box; other site
246198005267	Switch II region; other site
246198005268	G4 box; other site
246198005269	G5 box; other site
246198005270	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
246198005271	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
246198005272	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
246198005273	16S/18S rRNA binding site [nucleotide binding]; other site
246198005274	S13e-L30e interaction site [polypeptide binding]; other site
246198005275	25S rRNA binding site [nucleotide binding]; other site
246198005276	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
246198005277	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
246198005278	dimerization interface [polypeptide binding]; other site
246198005279	DPS ferroxidase diiron center [ion binding]; other site
246198005280	ion pore; other site
246198005281	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
246198005282	catalytic center binding site [active]
246198005283	ATP binding site [chemical binding]; other site
246198005284	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
246198005285	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
246198005286	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
246198005287	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
246198005288	RNA binding site [nucleotide binding]; other site
246198005289	active site
246198005290	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
246198005291	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
246198005292	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
246198005293	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
246198005294	Cna protein B-type domain; Region: Cna_B_2; pfam13715
246198005295	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
246198005296	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
246198005297	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
246198005298	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
246198005299	active site
246198005300	NTP binding site [chemical binding]; other site
246198005301	metal binding triad [ion binding]; metal-binding site
246198005302	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
246198005303	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
246198005304	Zn2+ binding site [ion binding]; other site
246198005305	Mg2+ binding site [ion binding]; other site
246198005306	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
246198005307	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
246198005308	HlyD family secretion protein; Region: HlyD_3; pfam13437
246198005309	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
246198005310	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
246198005311	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
246198005312	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
246198005313	putative trimer interface [polypeptide binding]; other site
246198005314	putative CoA binding site [chemical binding]; other site
246198005315	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
246198005316	catalytic residues [active]
246198005317	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
246198005318	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
246198005319	active site
246198005320	PHP Thumb interface [polypeptide binding]; other site
246198005321	metal binding site [ion binding]; metal-binding site
246198005322	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
246198005323	generic binding surface II; other site
246198005324	generic binding surface I; other site
246198005325	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
246198005326	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
246198005327	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
246198005328	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
246198005329	nucleoside/Zn binding site; other site
246198005330	dimer interface [polypeptide binding]; other site
246198005331	catalytic motif [active]
246198005332	hypothetical protein; Reviewed; Region: PRK12497
246198005333	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
246198005334	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
246198005335	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
246198005336	putative nucleotide binding site [chemical binding]; other site
246198005337	uridine monophosphate binding site [chemical binding]; other site
246198005338	homohexameric interface [polypeptide binding]; other site
246198005339	Transposase, Mutator family; Region: Transposase_mut; pfam00872
246198005340	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
246198005341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246198005342	Response regulator receiver domain; Region: Response_reg; pfam00072
246198005343	active site
246198005344	phosphorylation site [posttranslational modification]
246198005345	intermolecular recognition site; other site
246198005346	dimerization interface [polypeptide binding]; other site
246198005347	PglZ domain; Region: PglZ; pfam08665
246198005348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246198005349	TPR motif; other site
246198005350	binding surface
246198005351	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246198005352	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
246198005353	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
246198005354	hinge; other site
246198005355	active site
246198005356	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
246198005357	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
246198005358	CHC2 zinc finger; Region: zf-CHC2; cl17510
246198005359	Toprim-like; Region: Toprim_2; pfam13155
246198005360	Virulence-associated protein E; Region: VirE; pfam05272
246198005361	Helix-turn-helix domain; Region: HTH_17; pfam12728
246198005362	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
246198005363	ThiF family; Region: ThiF; pfam00899
246198005364	ATP binding site [chemical binding]; other site
246198005365	substrate interface [chemical binding]; other site
246198005366	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
246198005367	DNA binding residues [nucleotide binding]
246198005368	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
246198005369	dimerization interface [polypeptide binding]; other site
246198005370	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
246198005371	active site
246198005372	putative substrate binding region [chemical binding]; other site
246198005373	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
246198005374	putative acyl-acceptor binding pocket; other site
246198005375	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
246198005376	active site
246198005377	metal binding site [ion binding]; metal-binding site
246198005378	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246198005379	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
246198005380	active site
246198005381	DNA binding site [nucleotide binding]
246198005382	Int/Topo IB signature motif; other site
246198005383	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
246198005384	Predicted methyltransferases [General function prediction only]; Region: COG0313
246198005385	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
246198005386	putative SAM binding site [chemical binding]; other site
246198005387	putative homodimer interface [polypeptide binding]; other site
246198005388	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
246198005389	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
246198005390	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198005391	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198005392	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198005393	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198005394	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198005395	Resistant to P. syringae 6; Provisional; Region: PLN03210
246198005396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246198005397	binding surface
246198005398	TPR motif; other site
246198005399	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
246198005400	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
246198005401	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246198005402	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246198005403	ligand binding site [chemical binding]; other site
246198005404	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
246198005405	hypothetical protein; Provisional; Region: PRK08201
246198005406	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
246198005407	metal binding site [ion binding]; metal-binding site
246198005408	putative dimer interface [polypeptide binding]; other site
246198005409	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
246198005410	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
246198005411	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
246198005412	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246198005413	ATP binding site [chemical binding]; other site
246198005414	putative Mg++ binding site [ion binding]; other site
246198005415	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246198005416	nucleotide binding region [chemical binding]; other site
246198005417	ATP-binding site [chemical binding]; other site
246198005418	TRCF domain; Region: TRCF; pfam03461
246198005419	Repair protein; Region: Repair_PSII; pfam04536
246198005420	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
246198005421	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
246198005422	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
246198005423	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
246198005424	protein binding site [polypeptide binding]; other site
246198005425	PDZ-like domain; Region: PDZ_1; pfam12812
246198005426	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
246198005427	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
246198005428	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
246198005429	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
246198005430	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
246198005431	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
246198005432	rod shape-determining protein MreC; Provisional; Region: PRK13922
246198005433	rod shape-determining protein MreC; Region: MreC; pfam04085
246198005434	rod shape-determining protein MreB; Provisional; Region: PRK13927
246198005435	MreB and similar proteins; Region: MreB_like; cd10225
246198005436	nucleotide binding site [chemical binding]; other site
246198005437	Mg binding site [ion binding]; other site
246198005438	putative protofilament interaction site [polypeptide binding]; other site
246198005439	RodZ interaction site [polypeptide binding]; other site
246198005440	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
246198005441	purine monophosphate binding site [chemical binding]; other site
246198005442	dimer interface [polypeptide binding]; other site
246198005443	putative catalytic residues [active]
246198005444	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
246198005445	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
246198005446	minor groove reading motif; other site
246198005447	helix-hairpin-helix signature motif; other site
246198005448	substrate binding pocket [chemical binding]; other site
246198005449	active site
246198005450	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
246198005451	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
246198005452	DNA binding and oxoG recognition site [nucleotide binding]
246198005453	muropeptide transporter; Reviewed; Region: ampG; PRK11902
246198005454	muropeptide transporter; Validated; Region: ampG; cl17669
246198005455	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
246198005456	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
246198005457	putative ATP binding site [chemical binding]; other site
246198005458	putative substrate interface [chemical binding]; other site
246198005459	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
246198005460	EamA-like transporter family; Region: EamA; pfam00892
246198005461	EamA-like transporter family; Region: EamA; pfam00892
246198005462	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
246198005463	active site
246198005464	catalytic site [active]
246198005465	substrate binding site [chemical binding]; other site
246198005466	Cupin domain; Region: Cupin_2; pfam07883
246198005467	Predicted transcriptional regulators [Transcription]; Region: COG1733
246198005468	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
246198005469	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
246198005470	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
246198005471	Predicted permeases [General function prediction only]; Region: COG0795
246198005472	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
246198005473	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
246198005474	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
246198005475	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
246198005476	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
246198005477	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
246198005478	dimerization interface [polypeptide binding]; other site
246198005479	active site
246198005480	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
246198005481	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
246198005482	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
246198005483	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
246198005484	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
246198005485	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
246198005486	PBP superfamily domain; Region: PBP_like_2; pfam12849
246198005487	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
246198005488	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
246198005489	Resistant to P. syringae 6; Provisional; Region: PLN03210
246198005490	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
246198005491	S1 domain; Region: S1_2; pfam13509
246198005492	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
246198005493	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
246198005494	Walker A/P-loop; other site
246198005495	ATP binding site [chemical binding]; other site
246198005496	Q-loop/lid; other site
246198005497	ABC transporter signature motif; other site
246198005498	Walker B; other site
246198005499	D-loop; other site
246198005500	H-loop/switch region; other site
246198005501	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
246198005502	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859