-- dump date   	20140619_234846
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
365044000001	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044000002	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044000003	catalytic residues [active]
365044000004	catalytic nucleophile [active]
365044000005	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044000006	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044000007	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044000008	Synaptic Site I dimer interface [polypeptide binding]; other site
365044000009	DNA binding site [nucleotide binding]
365044000010	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365044000011	DNA-binding interface [nucleotide binding]; DNA binding site
365044000012	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
365044000013	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
365044000014	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000015	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
365044000016	active site
365044000017	metal binding site [ion binding]; metal-binding site
365044000018	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044000019	putative active site [active]
365044000020	catalytic site [active]
365044000021	PLD-like domain; Region: PLDc_2; pfam13091
365044000022	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044000023	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000024	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000025	zinc-finger of acetyl-transferase ESCO; Region: zf-C2H2_3; pfam13878
365044000026	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
365044000027	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000028	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365044000029	active site
365044000030	Int/Topo IB signature motif; other site
365044000031	DNA binding site [nucleotide binding]
365044000032	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
365044000033	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
365044000034	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
365044000035	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
365044000036	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
365044000037	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
365044000038	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
365044000039	active site
365044000040	catalytic residues [active]
365044000041	metal binding site [ion binding]; metal-binding site
365044000042	DmpG-like communication domain; Region: DmpG_comm; pfam07836
365044000043	acetaldehyde dehydrogenase; Validated; Region: PRK08300
365044000044	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
365044000045	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
365044000046	2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220
365044000047	glutathionine S-transferase; Provisional; Region: PRK10542
365044000048	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
365044000049	C-terminal domain interface [polypeptide binding]; other site
365044000050	GSH binding site (G-site) [chemical binding]; other site
365044000051	dimer interface [polypeptide binding]; other site
365044000052	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
365044000053	dimer interface [polypeptide binding]; other site
365044000054	N-terminal domain interface [polypeptide binding]; other site
365044000055	substrate binding pocket (H-site) [chemical binding]; other site
365044000056	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
365044000057	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
365044000058	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
365044000059	active site
365044000060	Fe binding site [ion binding]; other site
365044000061	cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Region: BphB_TodD; TIGR03325
365044000062	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
365044000063	NAD binding site [chemical binding]; other site
365044000064	active site
365044000065	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
365044000066	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044000067	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
365044000068	[2Fe-2S] cluster binding site [ion binding]; other site
365044000069	BphX-like; Region: BphX; pfam06139
365044000070	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044000071	inter-subunit interface; other site
365044000072	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044000073	Rieske non-heme iron oxygenase (RO) family, Biphenyl dioxygenase (BPDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of BPDO and similar proteins including cumene dioxygenase (CumDO); Region: Rieske_RO_Alpha_BPDO_like; cd03472
365044000074	beta subunit interaction site [polypeptide binding]; other site
365044000075	alpha subunit interaction site [polypeptide binding]; other site
365044000076	iron-sulfur cluster [ion binding]; other site
365044000077	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
365044000078	beta subunit interface [polypeptide binding]; other site
365044000079	alpha subunit interface [polypeptide binding]; other site
365044000080	active site
365044000081	substrate binding site [chemical binding]; other site
365044000082	Fe binding site [ion binding]; other site
365044000083	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
365044000084	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044000085	DNA-binding site [nucleotide binding]; DNA binding site
365044000086	FCD domain; Region: FCD; pfam07729
365044000087	Abortive infection C-terminus; Region: Abi_C; pfam14355
365044000088	Domain of unknown function (DUF932); Region: DUF932; pfam06067
365044000089	hypothetical protein; Reviewed; Region: PRK00024
365044000090	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
365044000091	MPN+ (JAMM) motif; other site
365044000092	Zinc-binding site [ion binding]; other site
365044000093	ParB-like nuclease domain; Region: ParBc; pfam02195
365044000094	Protein of unknown function (DUF736); Region: DUF736; pfam05284
365044000095	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365044000096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044000097	non-specific DNA binding site [nucleotide binding]; other site
365044000098	salt bridge; other site
365044000099	sequence-specific DNA binding site [nucleotide binding]; other site
365044000100	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
365044000101	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
365044000102	Replication initiator protein A; Region: RPA; pfam10134
365044000103	ParA-like protein; Provisional; Region: PHA02518
365044000104	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000105	P-loop; other site
365044000106	Magnesium ion binding site [ion binding]; other site
365044000107	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
365044000108	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
365044000109	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
365044000110	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
365044000111	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
365044000112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044000113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044000114	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
365044000115	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
365044000116	ABC1 family; Region: ABC1; cl17513
365044000117	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
365044000118	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365044000119	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
365044000120	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
365044000121	nucleophile elbow; other site
365044000122	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
365044000123	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044000124	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044000125	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044000126	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044000127	Protein export membrane protein; Region: SecD_SecF; cl14618
365044000128	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
365044000129	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
365044000130	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
365044000131	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044000132	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044000133	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
365044000134	catalytic loop [active]
365044000135	iron binding site [ion binding]; other site
365044000136	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213
365044000137	FAD binding pocket [chemical binding]; other site
365044000138	FAD binding motif [chemical binding]; other site
365044000139	phosphate binding motif [ion binding]; other site
365044000140	beta-alpha-beta structure motif; other site
365044000141	NAD binding pocket [chemical binding]; other site
365044000142	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
365044000143	Fatty acid desaturase; Region: FA_desaturase; pfam00487
365044000144	Di-iron ligands [ion binding]; other site
365044000145	choline dehydrogenase; Validated; Region: PRK02106
365044000146	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
365044000147	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
365044000148	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
365044000149	dimer interface [polypeptide binding]; other site
365044000150	acyl-activating enzyme (AAE) consensus motif; other site
365044000151	putative active site [active]
365044000152	AMP binding site [chemical binding]; other site
365044000153	putative CoA binding site [chemical binding]; other site
365044000154	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044000155	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
365044000156	NAD(P) binding site [chemical binding]; other site
365044000157	catalytic residues [active]
365044000158	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
365044000159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044000160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044000161	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
365044000162	dimerization interface [polypeptide binding]; other site
365044000163	substrate binding pocket [chemical binding]; other site
365044000164	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
365044000165	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044000166	Walker A motif; other site
365044000167	ATP binding site [chemical binding]; other site
365044000168	Walker B motif; other site
365044000169	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
365044000170	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
365044000171	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
365044000172	ATP binding site [chemical binding]; other site
365044000173	Walker A motif; other site
365044000174	hexamer interface [polypeptide binding]; other site
365044000175	Walker B motif; other site
365044000176	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
365044000177	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
365044000178	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
365044000179	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
365044000180	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044000181	Walker A motif; other site
365044000182	ATP binding site [chemical binding]; other site
365044000183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044000184	Walker B; other site
365044000185	D-loop; other site
365044000186	H-loop/switch region; other site
365044000187	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
365044000188	conjugal transfer protein TrbL; Provisional; Region: PRK13875
365044000189	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
365044000190	conjugal transfer protein TrbF; Provisional; Region: PRK13872
365044000191	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
365044000192	VirB7 interaction site; other site
365044000193	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
365044000194	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
365044000195	Protein of unknown function (DUF805); Region: DUF805; pfam05656
365044000196	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044000197	Active Sites [active]
365044000198	H-NS histone family; Region: Histone_HNS; pfam00816
365044000199	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
365044000200	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
365044000201	Nuclease-related domain; Region: NERD; pfam08378
365044000202	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
365044000203	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044000204	Walker A motif; other site
365044000205	ATP binding site [chemical binding]; other site
365044000206	Walker B motif; other site
365044000207	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
365044000208	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
365044000209	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
365044000210	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
365044000211	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
365044000212	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
365044000213	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
365044000214	Type II/IV secretion system protein; Region: T2SE; pfam00437
365044000215	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044000216	Walker A motif; other site
365044000217	ATP binding site [chemical binding]; other site
365044000218	Walker B motif; other site
365044000219	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
365044000220	VirB8 protein; Region: VirB8; pfam04335
365044000221	Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504
365044000222	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
365044000223	VirB7 interaction site; other site
365044000224	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
365044000225	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000226	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
365044000227	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044000228	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044000229	catalytic residue [active]
365044000230	Initiator Replication protein; Region: Rep_3; pfam01051
365044000231	Transposase domain (DUF772); Region: DUF772; pfam05598
365044000232	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
365044000233	ParB-like nuclease domain; Region: ParBc; cl02129
365044000234	ParA-like protein; Provisional; Region: PHA02518
365044000235	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000236	P-loop; other site
365044000237	Magnesium ion binding site [ion binding]; other site
365044000238	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000239	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
365044000240	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
365044000241	Phage integrase protein; Region: DUF3701; pfam12482
365044000242	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
365044000243	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000244	active site
365044000245	Int/Topo IB signature motif; other site
365044000246	DNA binding site [nucleotide binding]
365044000247	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
365044000248	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044000249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000250	Walker A motif; other site
365044000251	ATP binding site [chemical binding]; other site
365044000252	Walker B motif; other site
365044000253	arginine finger; other site
365044000254	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
365044000255	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
365044000256	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044000257	metal ion-dependent adhesion site (MIDAS); other site
365044000258	Protein phosphatase 2C; Region: PP2C_2; pfam13672
365044000259	Protein kinase domain; Region: Pkinase; pfam00069
365044000260	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044000261	active site
365044000262	ATP binding site [chemical binding]; other site
365044000263	substrate binding site [chemical binding]; other site
365044000264	activation loop (A-loop); other site
365044000265	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044000266	Part of AAA domain; Region: AAA_19; pfam13245
365044000267	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
365044000268	AAA domain; Region: AAA_12; pfam13087
365044000269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
365044000270	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
365044000271	homodimer interface [polypeptide binding]; other site
365044000272	putative active site [active]
365044000273	catalytic site [active]
365044000274	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
365044000275	putative homodimer interface [polypeptide binding]; other site
365044000276	putative active site [active]
365044000277	catalytic site [active]
365044000278	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
365044000279	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000280	ATP binding site [chemical binding]; other site
365044000281	putative Mg++ binding site [ion binding]; other site
365044000282	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044000283	nucleotide binding region [chemical binding]; other site
365044000284	ATP-binding site [chemical binding]; other site
365044000285	Restriction endonuclease; Region: Mrr_cat; pfam04471
365044000286	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044000287	ligand binding site [chemical binding]; other site
365044000288	Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731
365044000289	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
365044000290	DNA binding site [nucleotide binding]
365044000291	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
365044000292	rod shape-determining protein MreB; Provisional; Region: PRK13930
365044000293	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
365044000294	nucleotide binding site [chemical binding]; other site
365044000295	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365044000296	SBD interface [polypeptide binding]; other site
365044000297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000298	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044000299	Walker A motif; other site
365044000300	ATP binding site [chemical binding]; other site
365044000301	Walker B motif; other site
365044000302	arginine finger; other site
365044000303	Part of AAA domain; Region: AAA_19; pfam13245
365044000304	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000305	Family description; Region: UvrD_C_2; pfam13538
365044000306	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
365044000307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044000308	Walker A/P-loop; other site
365044000309	ATP binding site [chemical binding]; other site
365044000310	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365044000311	putative active site [active]
365044000312	putative metal-binding site [ion binding]; other site
365044000313	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044000314	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000315	ATP binding site [chemical binding]; other site
365044000316	putative Mg++ binding site [ion binding]; other site
365044000317	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044000318	nucleotide binding region [chemical binding]; other site
365044000319	ATP-binding site [chemical binding]; other site
365044000320	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
365044000321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
365044000322	primosomal protein DnaI; Reviewed; Region: PRK08939
365044000323	AAA domain; Region: AAA_21; pfam13304
365044000324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044000325	Walker B; other site
365044000326	D-loop; other site
365044000327	H-loop/switch region; other site
365044000328	Methyltransferase domain; Region: Methyltransf_26; pfam13659
365044000329	Nuclease-related domain; Region: NERD; pfam08378
365044000330	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
365044000331	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044000332	active site
365044000333	ATP binding site [chemical binding]; other site
365044000334	substrate binding site [chemical binding]; other site
365044000335	activation loop (A-loop); other site
365044000336	Protein kinase domain; Region: Pkinase; pfam00069
365044000337	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044000338	active site
365044000339	ATP binding site [chemical binding]; other site
365044000340	substrate binding site [chemical binding]; other site
365044000341	activation loop (A-loop); other site
365044000342	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
365044000343	Uncharacterized conserved protein [Function unknown]; Region: COG1479
365044000344	Protein of unknown function DUF262; Region: DUF262; pfam03235
365044000345	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044000346	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
365044000347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000348	Walker A motif; other site
365044000349	ATP binding site [chemical binding]; other site
365044000350	Walker B motif; other site
365044000351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000352	Integrase core domain; Region: rve; pfam00665
365044000353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000354	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
365044000355	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
365044000356	ParB-like nuclease domain; Region: ParBc; pfam02195
365044000357	PRTRC system protein C; Region: PRTRC_C; TIGR03738
365044000358	PRTRC system protein F; Region: PRTRC_F; TIGR03742
365044000359	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
365044000360	PRTRC system protein B; Region: PRTRC_B; TIGR03737
365044000361	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
365044000362	PRTRC system protein A; Region: PRTRC_A; TIGR03735
365044000363	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
365044000364	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
365044000365	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
365044000366	ATP binding site [chemical binding]; other site
365044000367	substrate interface [chemical binding]; other site
365044000368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044000369	S-adenosylmethionine binding site [chemical binding]; other site
365044000370	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
365044000371	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
365044000372	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
365044000373	helicase superfamily c-terminal domain; Region: HELICc; smart00490
365044000374	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
365044000375	Peptidase M15; Region: Peptidase_M15_3; cl01194
365044000376	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
365044000377	DNA polymerase sliding clamp subunit (PCNA homolog) [DNA replication, recombination, and repair]; Region: DnaN; COG0592
365044000378	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
365044000379	putative DNA binding surface [nucleotide binding]; other site
365044000380	dimer interface [polypeptide binding]; other site
365044000381	beta-clamp/clamp loader binding surface; other site
365044000382	beta-clamp/translesion DNA polymerase binding surface; other site
365044000383	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044000384	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
365044000385	Predicted transcriptional regulator [Transcription]; Region: COG2944
365044000386	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
365044000387	AAA domain; Region: AAA_18; pfam13238
365044000388	active site
365044000389	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000390	Part of AAA domain; Region: AAA_19; pfam13245
365044000391	Family description; Region: UvrD_C_2; pfam13538
365044000392	ParB-like nuclease domain; Region: ParBc; cl02129
365044000393	KorB domain; Region: KorB; pfam08535
365044000394	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044000395	active site
365044000396	metal binding site [ion binding]; metal-binding site
365044000397	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
365044000398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044000399	Q-loop/lid; other site
365044000400	ABC transporter signature motif; other site
365044000401	Walker B; other site
365044000402	D-loop; other site
365044000403	H-loop/switch region; other site
365044000404	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
365044000405	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044000406	dimer interface [polypeptide binding]; other site
365044000407	ssDNA binding site [nucleotide binding]; other site
365044000408	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044000409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
365044000410	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
365044000411	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
365044000412	active site
365044000413	metal binding site [ion binding]; metal-binding site
365044000414	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
365044000415	Putative helicase; Region: TraI_2; pfam07514
365044000416	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
365044000417	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
365044000418	RRXRR protein; Region: RRXRR; pfam14239
365044000419	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000420	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044000421	active site
365044000422	Domain of unknown function (DUF4400); Region: DUF4400; pfam14348
365044000423	RRXRR protein; Region: RRXRR; pfam14239
365044000424	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044000425	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000426	active site
365044000427	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
365044000428	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044000429	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000430	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000431	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
365044000432	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
365044000433	PRTRC system protein D; Region: PRTRC_D; TIGR03739
365044000434	Mg binding site [ion binding]; other site
365044000435	nucleotide binding site [chemical binding]; other site
365044000436	putative protofilament interface [polypeptide binding]; other site
365044000437	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
365044000438	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000439	active site
365044000440	catalytic residues [active]
365044000441	DNA binding site [nucleotide binding]
365044000442	Int/Topo IB signature motif; other site
365044000443	AntA/AntB antirepressor; Region: AntA; pfam08346
365044000444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
365044000445	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044000446	active site
365044000447	phosphorylation site [posttranslational modification]
365044000448	intermolecular recognition site; other site
365044000449	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044000450	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044000451	DNA binding residues [nucleotide binding]
365044000452	dimerization interface [polypeptide binding]; other site
365044000453	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044000454	Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457
365044000455	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
365044000456	ATP binding site [chemical binding]; other site
365044000457	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
365044000458	HTH-like domain; Region: HTH_21; pfam13276
365044000459	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044000460	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000461	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044000462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044000463	Transposase; Region: HTH_Tnp_1; pfam01527
365044000464	Y-family of DNA polymerases; Region: PolY; cl12025
365044000465	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
365044000466	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
365044000467	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
365044000468	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
365044000469	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044000470	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044000471	active site
365044000472	substrate binding site [chemical binding]; other site
365044000473	Endonuclease I; Region: Endonuclease_1; pfam04231
365044000474	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044000475	putative active site [active]
365044000476	Putative phage integrase; Region: Phage_Integr_2; pfam13009
365044000477	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000478	DNA binding site [nucleotide binding]
365044000479	active site
365044000480	Int/Topo IB signature motif; other site
365044000481	catalytic residues [active]
365044000482	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000483	DNA binding site [nucleotide binding]
365044000484	active site
365044000485	Int/Topo IB signature motif; other site
365044000486	catalytic residues [active]
365044000487	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044000488	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044000489	active site
365044000490	Mg2+ binding site [ion binding]; other site
365044000491	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
365044000492	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000493	ATP binding site [chemical binding]; other site
365044000494	putative Mg++ binding site [ion binding]; other site
365044000495	helicase superfamily c-terminal domain; Region: HELICc; smart00490
365044000496	nucleotide binding region [chemical binding]; other site
365044000497	ATP-binding site [chemical binding]; other site
365044000498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044000499	AAA domain; Region: AAA_23; pfam13476
365044000500	Walker A/P-loop; other site
365044000501	ATP binding site [chemical binding]; other site
365044000502	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
365044000503	Q-loop/lid; other site
365044000504	ABC transporter signature motif; other site
365044000505	Walker B; other site
365044000506	D-loop; other site
365044000507	H-loop/switch region; other site
365044000508	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
365044000509	AAA domain; Region: AAA_11; pfam13086
365044000510	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000511	ATP binding site [chemical binding]; other site
365044000512	AAA domain; Region: AAA_12; pfam13087
365044000513	Tim44-like domain; Region: Tim44; cl09208
365044000514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000515	Integrase core domain; Region: rve; pfam00665
365044000516	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000517	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044000518	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
365044000519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000520	Walker A motif; other site
365044000521	ATP binding site [chemical binding]; other site
365044000522	Walker B motif; other site
365044000523	TrfA protein; Region: TrfA; pfam07042
365044000524	Replication initiator protein A; Region: RPA; cl17860
365044000525	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
365044000526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
365044000527	RRXRR protein; Region: RRXRR; pfam14239
365044000528	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000529	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044000530	active site
365044000531	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
365044000532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000533	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044000534	aspartate carbamoyltransferase; Provisional; Region: PRK11891
365044000535	Fic family protein [Function unknown]; Region: COG3177
365044000536	Fic/DOC family; Region: Fic; pfam02661
365044000537	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044000538	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000539	Int/Topo IB signature motif; other site
365044000540	DNA binding site [nucleotide binding]
365044000541	active site
365044000542	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
365044000543	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000544	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
365044000545	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044000546	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044000547	active site
365044000548	substrate binding site [chemical binding]; other site
365044000549	Mg2+ binding site [ion binding]; other site
365044000550	AAA ATPase domain; Region: AAA_16; pfam13191
365044000551	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
365044000552	active site
365044000553	catalytic residues [active]
365044000554	Dynein, heavy chain [Cytoskeleton]; Region: DYN1; COG5245
365044000555	P-loop containing region of AAA domain; Region: AAA_29; cl17516
365044000556	Transposase; Region: HTH_Tnp_1; pfam01527
365044000557	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044000558	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365044000559	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044000560	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044000561	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044000562	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044000563	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044000564	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044000565	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
365044000566	Predicted ATPase [General function prediction only]; Region: COG5293
365044000567	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
365044000568	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
365044000569	ParB-like nuclease domain; Region: ParB; smart00470
365044000570	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
365044000571	TrfA protein; Region: TrfA; pfam07042
365044000572	Replication initiator protein A; Region: RPA; cl17860
365044000573	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
365044000574	ParB-like nuclease domain; Region: ParB; smart00470
365044000575	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
365044000576	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000577	P-loop; other site
365044000578	Magnesium ion binding site [ion binding]; other site
365044000579	Phage integrase protein; Region: DUF3701; pfam12482
365044000580	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000581	active site
365044000582	DNA binding site [nucleotide binding]
365044000583	Int/Topo IB signature motif; other site
365044000584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044000585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044000586	dimer interface [polypeptide binding]; other site
365044000587	phosphorylation site [posttranslational modification]
365044000588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044000589	ATP binding site [chemical binding]; other site
365044000590	Mg2+ binding site [ion binding]; other site
365044000591	G-X-G motif; other site
365044000592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044000593	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
365044000594	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
365044000595	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
365044000596	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000597	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
365044000598	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044000599	motif II; other site
365044000600	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365044000601	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044000602	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044000603	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044000604	Winged helix-turn helix; Region: HTH_33; pfam13592
365044000605	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000606	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044000607	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044000608	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000609	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044000610	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000611	metal-binding site [ion binding]
365044000612	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
365044000613	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000614	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000615	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
365044000616	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000617	Soluble P-type ATPase [General function prediction only]; Region: COG4087
365044000618	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
365044000619	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
365044000620	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
365044000621	active site
365044000622	dimer interface [polypeptide binding]; other site
365044000623	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
365044000624	Ligand Binding Site [chemical binding]; other site
365044000625	Molecular Tunnel; other site
365044000626	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
365044000627	putative active site [active]
365044000628	catalytic residue [active]
365044000629	phosphoglucomutase; Validated; Region: PRK07564
365044000630	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
365044000631	active site
365044000632	substrate binding site [chemical binding]; other site
365044000633	metal binding site [ion binding]; metal-binding site
365044000634	putative phosphoketolase; Provisional; Region: PRK05261
365044000635	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
365044000636	TPP-binding site; other site
365044000637	XFP C-terminal domain; Region: XFP_C; pfam09363
365044000638	Acetokinase family; Region: Acetate_kinase; cl17229
365044000639	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
365044000640	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365044000641	TPP-binding site [chemical binding]; other site
365044000642	dimer interface [polypeptide binding]; other site
365044000643	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044000644	PYR/PP interface [polypeptide binding]; other site
365044000645	dimer interface [polypeptide binding]; other site
365044000646	TPP binding site [chemical binding]; other site
365044000647	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044000648	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
365044000649	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
365044000650	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
365044000651	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
365044000652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
365044000653	Putative glucoamylase; Region: Glycoamylase; pfam10091
365044000654	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044000655	Winged helix-turn helix; Region: HTH_29; pfam13551
365044000656	Homeodomain-like domain; Region: HTH_32; pfam13565
365044000657	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
365044000658	PLD-like domain; Region: PLDc_2; pfam13091
365044000659	putative active site [active]
365044000660	catalytic site [active]
365044000661	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
365044000662	PLD-like domain; Region: PLDc_2; pfam13091
365044000663	putative active site [active]
365044000664	catalytic site [active]
365044000665	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
365044000666	Outer membrane efflux protein; Region: OEP; pfam02321
365044000667	Outer membrane efflux protein; Region: OEP; pfam02321
365044000668	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
365044000669	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044000670	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
365044000671	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044000672	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
365044000673	Multicopper oxidase; Region: Cu-oxidase; pfam00394
365044000674	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
365044000675	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
365044000676	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
365044000677	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000678	metal-binding site [ion binding]
365044000679	Short C-terminal domain; Region: SHOCT; pfam09851
365044000680	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000681	metal-binding site [ion binding]
365044000682	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
365044000683	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000684	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
365044000685	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000686	Soluble P-type ATPase [General function prediction only]; Region: COG4087
365044000687	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
365044000688	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
365044000689	NAD binding site [chemical binding]; other site
365044000690	homotetramer interface [polypeptide binding]; other site
365044000691	homodimer interface [polypeptide binding]; other site
365044000692	substrate binding site [chemical binding]; other site
365044000693	active site
365044000694	Acetokinase family; Region: Acetate_kinase; cl17229
365044000695	propionate/acetate kinase; Provisional; Region: PRK12379
365044000696	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
365044000697	Propanediol utilisation protein PduL; Region: PduL; pfam06130
365044000698	Propanediol utilisation protein PduL; Region: PduL; pfam06130
365044000699	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
365044000700	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044000701	Creatinine amidohydrolase; Region: Creatininase; cl00618
365044000702	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
365044000703	Transposase; Region: HTH_Tnp_1; pfam01527
365044000704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044000705	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365044000706	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044000707	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044000708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044000709	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044000710	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044000711	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044000712	Domain of unknown function (DUF305); Region: DUF305; cl17794
365044000713	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
365044000714	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
365044000715	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000716	metal-binding site [ion binding]
365044000717	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
365044000718	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
365044000719	Repair protein; Region: Repair_PSII; pfam04536
365044000720	Repair protein; Region: Repair_PSII; pfam04536
365044000721	YHS domain; Region: YHS; pfam04945
365044000722	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044000723	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000724	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044000725	motif II; other site
365044000726	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000727	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000728	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000729	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000730	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
365044000731	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
365044000732	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
365044000733	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
365044000734	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
365044000735	Outer membrane efflux protein; Region: OEP; pfam02321
365044000736	Copper resistance protein K; Region: CopK; pfam11525
365044000737	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
365044000738	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044000739	dimerization interface [polypeptide binding]; other site
365044000740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044000741	dimer interface [polypeptide binding]; other site
365044000742	phosphorylation site [posttranslational modification]
365044000743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044000744	ATP binding site [chemical binding]; other site
365044000745	Mg2+ binding site [ion binding]; other site
365044000746	G-X-G motif; other site
365044000747	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
365044000748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044000749	active site
365044000750	phosphorylation site [posttranslational modification]
365044000751	intermolecular recognition site; other site
365044000752	dimerization interface [polypeptide binding]; other site
365044000753	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044000754	DNA binding site [nucleotide binding]
365044000755	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
365044000756	Domain of unknown function (DUF305); Region: DUF305; cl17794
365044000757	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
365044000758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044000759	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
365044000760	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044000761	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044000762	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044000763	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
365044000764	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000765	Int/Topo IB signature motif; other site
365044000766	DNA binding site [nucleotide binding]
365044000767	active site
365044000768	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
365044000769	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
365044000770	H-NS histone family; Region: Histone_HNS; pfam00816
365044000771	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
365044000772	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
365044000773	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
365044000774	putative S-transferase; Provisional; Region: PRK11752
365044000775	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
365044000776	C-terminal domain interface [polypeptide binding]; other site
365044000777	GSH binding site (G-site) [chemical binding]; other site
365044000778	dimer interface [polypeptide binding]; other site
365044000779	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
365044000780	dimer interface [polypeptide binding]; other site
365044000781	N-terminal domain interface [polypeptide binding]; other site
365044000782	active site
365044000783	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044000784	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
365044000785	putative C-terminal domain interface [polypeptide binding]; other site
365044000786	putative GSH binding site (G-site) [chemical binding]; other site
365044000787	putative dimer interface [polypeptide binding]; other site
365044000788	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044000789	N-terminal domain interface [polypeptide binding]; other site
365044000790	dimer interface [polypeptide binding]; other site
365044000791	substrate binding pocket (H-site) [chemical binding]; other site
365044000792	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
365044000793	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044000794	Active Sites [active]
365044000795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044000796	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044000797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044000798	ATP binding site [chemical binding]; other site
365044000799	Mg2+ binding site [ion binding]; other site
365044000800	G-X-G motif; other site
365044000801	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
365044000802	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044000803	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044000805	Transposase; Region: HTH_Tnp_1; cl17663
365044000806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000807	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044000808	Walker A motif; other site
365044000809	ATP binding site [chemical binding]; other site
365044000810	Walker B motif; other site
365044000811	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044000812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044000813	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
365044000814	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
365044000815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000816	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044000817	Walker A motif; other site
365044000818	ATP binding site [chemical binding]; other site
365044000819	Walker B motif; other site
365044000820	arginine finger; other site
365044000821	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
365044000822	PIN domain; Region: PIN_Smg5-Smg6-like; cd09880
365044000823	putative active site [active]
365044000824	AAA domain; Region: AAA_11; pfam13086
365044000825	Part of AAA domain; Region: AAA_19; pfam13245
365044000826	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
365044000827	AAA domain; Region: AAA_12; pfam13087
365044000828	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044000829	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000830	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044000831	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
365044000832	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
365044000833	active site
365044000834	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
365044000835	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
365044000836	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
365044000837	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000838	AAA domain; Region: AAA_27; pfam13514
365044000839	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044000840	AAA domain; Region: AAA_25; pfam13481
365044000841	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044000842	Walker A motif; other site
365044000843	ATP binding site [chemical binding]; other site
365044000844	Walker B motif; other site
365044000845	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
365044000846	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044000847	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
365044000848	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044000849	putative active site [active]
365044000850	putative metal binding site [ion binding]; other site
365044000851	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
365044000852	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
365044000853	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
365044000854	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365044000855	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044000856	non-specific DNA binding site [nucleotide binding]; other site
365044000857	salt bridge; other site
365044000858	sequence-specific DNA binding site [nucleotide binding]; other site
365044000859	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
365044000860	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
365044000861	homodimer interface [polypeptide binding]; other site
365044000862	chemical substrate binding site [chemical binding]; other site
365044000863	oligomer interface [polypeptide binding]; other site
365044000864	metal binding site [ion binding]; metal-binding site
365044000865	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
365044000866	putative active site [active]
365044000867	Zn binding site [ion binding]; other site
365044000868	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
365044000869	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000870	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000871	Protein of unknown function (DUF433); Region: DUF433; pfam04255
365044000872	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365044000873	Cation efflux family; Region: Cation_efflux; pfam01545
365044000874	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
365044000875	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
365044000876	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044000877	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
365044000878	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
365044000879	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
365044000880	YtkA-like; Region: YtkA; pfam13115
365044000881	C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; Region: W2; cl17013
365044000882	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044000883	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000884	active site
365044000885	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
365044000886	nucleotide binding site/active site [active]
365044000887	HIT family signature motif; other site
365044000888	catalytic residue [active]
365044000889	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
365044000890	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
365044000891	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
365044000892	generic binding surface II; other site
365044000893	generic binding surface I; other site
365044000894	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
365044000895	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044000896	dimer interface [polypeptide binding]; other site
365044000897	ssDNA binding site [nucleotide binding]; other site
365044000898	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044000899	TfoX N-terminal domain; Region: TfoX_N; pfam04993
365044000900	Cupin domain; Region: Cupin_2; cl17218
365044000901	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
365044000902	H-NS histone family; Region: Histone_HNS; pfam00816
365044000903	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
365044000904	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
365044000905	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
365044000906	Restriction endonuclease; Region: Mrr_cat; pfam04471
365044000907	Uncharacterized conserved protein [Function unknown]; Region: COG4544
365044000908	Y-family of DNA polymerases; Region: PolY; cl12025
365044000909	DNA binding site [nucleotide binding]
365044000910	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
365044000911	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
365044000912	putative active site [active]
365044000913	putative PHP Thumb interface [polypeptide binding]; other site
365044000914	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
365044000915	generic binding surface II; other site
365044000916	generic binding surface I; other site
365044000917	Y-family of DNA polymerases; Region: PolY; cl12025
365044000918	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
365044000919	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
365044000920	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044000921	active site
365044000922	substrate binding site [chemical binding]; other site
365044000923	Mg2+ binding site [ion binding]; other site
365044000924	Y-family of DNA polymerases; Region: PolY; cl12025
365044000925	DNA binding site [nucleotide binding]
365044000926	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
365044000927	oxyanion hole [active]
365044000928	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000929	Part of AAA domain; Region: AAA_19; pfam13245
365044000930	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365044000931	G2 box; other site
365044000932	Switch I region; other site
365044000933	G3 box; other site
365044000934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044000935	Walker A/P-loop; other site
365044000936	ATP binding site [chemical binding]; other site
365044000937	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
365044000938	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365044000939	putative active site [active]
365044000940	putative metal-binding site [ion binding]; other site
365044000941	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
365044000942	RNA binding site [nucleotide binding]; other site
365044000943	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
365044000944	putative metal binding site [ion binding]; other site
365044000945	Uncharacterized conserved protein [Function unknown]; Region: COG1432
365044000946	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
365044000947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044000948	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
365044000949	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
365044000950	ATP binding site [chemical binding]; other site
365044000951	helicase superfamily c-terminal domain; Region: HELICc; smart00490
365044000952	nucleotide binding region [chemical binding]; other site
365044000953	ATP-binding site [chemical binding]; other site
365044000954	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
365044000955	PLD-like domain; Region: PLDc_2; pfam13091
365044000956	putative active site [active]
365044000957	catalytic site [active]
365044000958	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
365044000959	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365044000960	Methyltransferase domain; Region: Methyltransf_26; pfam13659
365044000961	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
365044000962	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044000963	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000964	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000965	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
365044000966	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
365044000967	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
365044000968	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
365044000969	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
365044000970	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000971	ATP binding site [chemical binding]; other site
365044000972	putative Mg++ binding site [ion binding]; other site
365044000973	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044000974	Phage integrase protein; Region: DUF3701; pfam12482
365044000975	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
365044000976	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000977	active site
365044000978	catalytic residues [active]
365044000979	DNA binding site [nucleotide binding]
365044000980	Int/Topo IB signature motif; other site
365044000981	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
365044000982	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000983	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044000984	P loop; other site
365044000985	P-loop; other site
365044000986	Nucleotide binding site [chemical binding]; other site
365044000987	Magnesium ion binding site [ion binding]; other site
365044000988	DTAP/Switch II; other site
365044000989	Switch I; other site
365044000990	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
365044000991	ParB-like nuclease domain; Region: ParBc; cl02129
365044000992	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
365044000993	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
365044000994	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000995	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044000996	Initiator Replication protein; Region: Rep_3; pfam01051
365044000997	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000998	active site
365044000999	Int/Topo IB signature motif; other site
365044001000	catalytic residues [active]
365044001001	DNA binding site [nucleotide binding]
365044001002	Fic family protein [Function unknown]; Region: COG3177
365044001003	Fic/DOC family; Region: Fic; pfam02661
365044001004	Archaeal ATPase; Region: Arch_ATPase; pfam01637
365044001005	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
365044001006	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
365044001007	hypothetical protein; Provisional; Region: PRK02237
365044001008	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
365044001009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
365044001010	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
365044001011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044001012	S-adenosylmethionine binding site [chemical binding]; other site
365044001013	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
365044001014	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
365044001015	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044001016	active site
365044001017	ATP binding site [chemical binding]; other site
365044001018	substrate binding site [chemical binding]; other site
365044001019	activation loop (A-loop); other site
365044001020	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
365044001021	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
365044001022	Part of AAA domain; Region: AAA_19; pfam13245
365044001023	Family description; Region: UvrD_C_2; pfam13538
365044001024	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365044001025	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365044001026	PLD-like domain; Region: PLDc_2; pfam13091
365044001027	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044001028	putative active site [active]
365044001029	catalytic site [active]
365044001030	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
365044001031	putative homodimer interface [polypeptide binding]; other site
365044001032	putative active site [active]
365044001033	catalytic site [active]
365044001034	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
365044001035	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365044001036	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044001037	amidase; Provisional; Region: PRK07486
365044001038	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
365044001039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044001040	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
365044001041	dimerization interface [polypeptide binding]; other site
365044001042	substrate binding pocket [chemical binding]; other site
365044001043	D-serine dehydratase; Provisional; Region: PRK02991
365044001044	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044001045	catalytic residue [active]
365044001046	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044001047	amidase; Provisional; Region: PRK07486
365044001048	Amidase; Region: Amidase; cl11426
365044001049	enoyl-CoA hydratase; Provisional; Region: PRK07509
365044001050	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
365044001051	Transcriptional regulators [Transcription]; Region: MarR; COG1846
365044001052	MarR family; Region: MarR_2; cl17246
365044001053	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044001054	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365044001055	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
365044001056	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
365044001057	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
365044001058	FMN-binding pocket [chemical binding]; other site
365044001059	flavin binding motif; other site
365044001060	phosphate binding motif [ion binding]; other site
365044001061	beta-alpha-beta structure motif; other site
365044001062	NAD binding pocket [chemical binding]; other site
365044001063	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044001064	catalytic loop [active]
365044001065	iron binding site [ion binding]; other site
365044001066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044001067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
365044001068	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
365044001069	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044001070	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
365044001071	hydrophobic ligand binding site; other site
365044001072	Hemerythrin; Region: Hemerythrin; cd12107
365044001073	Fe binding site [ion binding]; other site
365044001074	DDE superfamily endonuclease; Region: DDE_5; cl17874
365044001075	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044001076	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
365044001077	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
365044001078	dimerization interface [polypeptide binding]; other site
365044001079	active site
365044001080	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
365044001081	peptide binding site [polypeptide binding]; other site
365044001082	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
365044001083	toxin interface [polypeptide binding]; other site
365044001084	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
365044001085	Zn binding site [ion binding]; other site
365044001086	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001087	non-specific DNA binding site [nucleotide binding]; other site
365044001088	salt bridge; other site
365044001089	sequence-specific DNA binding site [nucleotide binding]; other site
365044001090	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044001091	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044001092	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044001093	catalytic residues [active]
365044001094	catalytic nucleophile [active]
365044001095	Recombinase; Region: Recombinase; pfam07508
365044001096	Helix-turn-helix domain; Region: HTH_17; pfam12728
365044001097	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044001098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044001099	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044001100	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044001101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044001102	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044001103	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044001104	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001105	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001106	putative metal binding site [ion binding]; other site
365044001107	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
365044001108	metal ion-dependent adhesion site (MIDAS); other site
365044001109	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044001110	Transposase domain (DUF772); Region: DUF772; pfam05598
365044001111	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
365044001112	Transposase domain (DUF772); Region: DUF772; pfam05598
365044001113	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044001114	DDE superfamily endonuclease; Region: DDE_4; cl17710
365044001115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
365044001116	HTH-like domain; Region: HTH_21; pfam13276
365044001117	Integrase core domain; Region: rve; pfam00665
365044001118	Transposase; Region: HTH_Tnp_1; pfam01527
365044001119	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
365044001120	hypothetical protein; Provisional; Region: PRK14013
365044001121	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001122	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001123	putative metal binding site [ion binding]; other site
365044001124	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001125	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001126	putative metal binding site [ion binding]; other site
365044001127	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001128	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001129	putative metal binding site [ion binding]; other site
365044001130	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
365044001131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044001132	active site
365044001133	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
365044001134	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
365044001135	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
365044001136	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
365044001137	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001138	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001139	putative metal binding site [ion binding]; other site
365044001140	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
365044001141	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001142	putative metal binding site [ion binding]; other site
365044001143	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044001144	substrate binding site [chemical binding]; other site
365044001145	activation loop (A-loop); other site
365044001146	Protein phosphatase 2C; Region: PP2C_2; pfam13672
365044001147	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044001148	metal ion-dependent adhesion site (MIDAS); other site
365044001149	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044001150	metal ion-dependent adhesion site (MIDAS); other site
365044001151	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001152	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001153	putative metal binding site [ion binding]; other site
365044001154	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
365044001155	metal ion-dependent adhesion site (MIDAS); other site
365044001156	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
365044001157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
365044001158	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
365044001159	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044001160	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044001161	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
365044001162	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
365044001163	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
365044001164	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044001165	Bacterial TniB protein; Region: TniB; pfam05621
365044001166	AAA domain; Region: AAA_22; pfam13401
365044001167	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
365044001168	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044001169	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001170	Integrase core domain; Region: rve; pfam00665
365044001171	Protein of unknown function (DUF465); Region: DUF465; cl01070
365044001172	Phage integrase protein; Region: DUF3701; pfam12482
365044001173	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
365044001174	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044001175	active site
365044001176	DNA binding site [nucleotide binding]
365044001177	Int/Topo IB signature motif; other site
365044001178	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
365044001179	ParB-like nuclease domain; Region: ParB; smart00470
365044001180	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
365044001181	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001182	P-loop; other site
365044001183	Magnesium ion binding site [ion binding]; other site
365044001184	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001185	Initiator Replication protein; Region: Rep_3; pfam01051
365044001186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001187	non-specific DNA binding site [nucleotide binding]; other site
365044001188	salt bridge; other site
365044001189	sequence-specific DNA binding site [nucleotide binding]; other site
365044001190	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044001191	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
365044001192	ParB-like nuclease domain; Region: ParB; smart00470
365044001193	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
365044001194	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365044001195	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044001196	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044001197	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044001198	catalytic residues [active]
365044001199	catalytic nucleophile [active]
365044001200	Recombinase; Region: Recombinase; pfam07508
365044001201	Helix-turn-helix domain; Region: HTH_17; pfam12728
365044001202	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044001203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044001204	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044001205	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044001206	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365044001207	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044001208	Transposase; Region: HTH_Tnp_1; pfam01527
365044001209	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365044001210	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044001211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044001212	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044001213	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044001214	DDE superfamily endonuclease; Region: DDE_5; cl17874
365044001215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044001216	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044001217	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044001218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044001219	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044001220	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044001221	H-NS histone family; Region: Histone_HNS; pfam00816
365044001222	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
365044001223	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
365044001224	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044001225	Ligand Binding Site [chemical binding]; other site
365044001226	Dodecin; Region: Dodecin; pfam07311
365044001227	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
365044001228	generic binding surface I; other site
365044001229	generic binding surface II; other site
365044001230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
365044001231	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
365044001232	Phage Tail Collar Domain; Region: Collar; pfam07484
365044001233	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365044001234	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044001235	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001236	Homeodomain-like domain; Region: HTH_32; pfam13565
365044001237	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
365044001238	Calcium binding; Region: Calci_bind_CcbP; pfam11535
365044001239	SnoaL-like domain; Region: SnoaL_2; pfam12680
365044001240	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044001241	H-NS histone family; Region: Histone_HNS; pfam00816
365044001242	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
365044001243	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
365044001244	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
365044001245	putative S-transferase; Provisional; Region: PRK11752
365044001246	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
365044001247	C-terminal domain interface [polypeptide binding]; other site
365044001248	GSH binding site (G-site) [chemical binding]; other site
365044001249	dimer interface [polypeptide binding]; other site
365044001250	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
365044001251	dimer interface [polypeptide binding]; other site
365044001252	N-terminal domain interface [polypeptide binding]; other site
365044001253	active site
365044001254	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044001255	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
365044001256	putative C-terminal domain interface [polypeptide binding]; other site
365044001257	putative GSH binding site (G-site) [chemical binding]; other site
365044001258	putative dimer interface [polypeptide binding]; other site
365044001259	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044001260	N-terminal domain interface [polypeptide binding]; other site
365044001261	dimer interface [polypeptide binding]; other site
365044001262	substrate binding pocket (H-site) [chemical binding]; other site
365044001263	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044001264	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001265	Homeodomain-like domain; Region: HTH_32; pfam13565
365044001266	Integrase core domain; Region: rve; pfam00665
365044001267	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365044001268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044001269	ABC transporter signature motif; other site
365044001270	Walker B; other site
365044001271	D-loop; other site
365044001272	H-loop/switch region; other site
365044001273	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
365044001274	AAA domain; Region: AAA_21; pfam13304
365044001275	threonine and homoserine efflux system; Provisional; Region: PRK10532
365044001276	EamA-like transporter family; Region: EamA; pfam00892
365044001277	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
365044001278	DDE superfamily endonuclease; Region: DDE_5; pfam13546
365044001279	Putative transposase; Region: Y2_Tnp; pfam04986
365044001280	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
365044001281	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044001282	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044001283	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044001284	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
365044001285	putative active site [active]
365044001286	catalytic triad [active]
365044001287	putative dimer interface [polypeptide binding]; other site
365044001288	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044001289	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
365044001290	putative ligand binding site [chemical binding]; other site
365044001291	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044001292	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044001293	TM-ABC transporter signature motif; other site
365044001294	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044001295	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044001296	TM-ABC transporter signature motif; other site
365044001297	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044001298	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044001299	Walker A/P-loop; other site
365044001300	ATP binding site [chemical binding]; other site
365044001301	Q-loop/lid; other site
365044001302	ABC transporter signature motif; other site
365044001303	Walker B; other site
365044001304	D-loop; other site
365044001305	H-loop/switch region; other site
365044001306	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044001307	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044001308	Walker A/P-loop; other site
365044001309	ATP binding site [chemical binding]; other site
365044001310	Q-loop/lid; other site
365044001311	ABC transporter signature motif; other site
365044001312	Walker B; other site
365044001313	D-loop; other site
365044001314	H-loop/switch region; other site
365044001315	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
365044001316	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044001317	Homeodomain-like domain; Region: HTH_23; pfam13384
365044001318	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001319	Homeodomain-like domain; Region: HTH_32; pfam13565
365044001320	Winged helix-turn helix; Region: HTH_33; pfam13592
365044001321	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044001322	Dodecin; Region: Dodecin; pfam07311
365044001323	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044001324	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044001325	DNA-binding site [nucleotide binding]; DNA binding site
365044001326	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044001327	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044001328	homodimer interface [polypeptide binding]; other site
365044001329	catalytic residue [active]
365044001330	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
365044001331	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
365044001332	dimer interface [polypeptide binding]; other site
365044001333	TPP-binding site [chemical binding]; other site
365044001334	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
365044001335	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044001336	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044001337	putative DNA binding site [nucleotide binding]; other site
365044001338	putative Zn2+ binding site [ion binding]; other site
365044001339	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044001340	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044001341	AsnC family; Region: AsnC_trans_reg; pfam01037
365044001342	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
365044001343	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044001344	oligomeric interface; other site
365044001345	putative active site [active]
365044001346	homodimer interface [polypeptide binding]; other site
365044001347	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
365044001348	Phage Tail Collar Domain; Region: Collar; pfam07484
365044001349	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
365044001350	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
365044001351	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
365044001352	Replication initiator protein A; Region: RPA; cl17860
365044001353	ParA-like protein; Provisional; Region: PHA02518
365044001354	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001355	P-loop; other site
365044001356	Magnesium ion binding site [ion binding]; other site
365044001357	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365044001358	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
365044001359	Methyltransferase domain; Region: Methyltransf_26; pfam13659
365044001360	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365044001361	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
365044001362	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365044001363	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
365044001364	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
365044001365	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
365044001366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
365044001367	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
365044001368	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
365044001369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044001370	ATP binding site [chemical binding]; other site
365044001371	putative Mg++ binding site [ion binding]; other site
365044001372	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
365044001373	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
365044001374	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
365044001375	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044001376	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
365044001377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001378	Walker A motif; other site
365044001379	ATP binding site [chemical binding]; other site
365044001380	Walker B motif; other site
365044001381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044001382	Integrase core domain; Region: rve; pfam00665
365044001383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044001384	Domain of unknown function (DUF955); Region: DUF955; cl01076
365044001385	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001386	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365044001387	non-specific DNA binding site [nucleotide binding]; other site
365044001388	salt bridge; other site
365044001389	sequence-specific DNA binding site [nucleotide binding]; other site
365044001390	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
365044001391	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365044001392	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044001393	catalytic residues [active]
365044001394	catalytic nucleophile [active]
365044001395	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044001396	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044001397	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044001398	Synaptic Site I dimer interface [polypeptide binding]; other site
365044001399	DNA binding site [nucleotide binding]
365044001400	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001401	Walker A motif; other site
365044001402	ATP binding site [chemical binding]; other site
365044001403	Walker B motif; other site
365044001404	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
365044001405	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044001406	active site
365044001407	DNA binding site [nucleotide binding]
365044001408	Int/Topo IB signature motif; other site
365044001409	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044001410	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044001411	active site
365044001412	substrate binding site [chemical binding]; other site
365044001413	Mg2+ binding site [ion binding]; other site
365044001414	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
365044001415	CHC2 zinc finger; Region: zf-CHC2; cl17510
365044001416	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
365044001417	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
365044001418	active site
365044001419	metal binding site [ion binding]; metal-binding site
365044001420	interdomain interaction site; other site
365044001421	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365044001422	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044001423	putative active site [active]
365044001424	putative NTP binding site [chemical binding]; other site
365044001425	putative nucleic acid binding site [nucleotide binding]; other site
365044001426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
365044001427	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
365044001428	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044001429	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365044001430	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044001431	putative active site [active]
365044001432	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
365044001433	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
365044001434	putative active site [active]
365044001435	T5orf172 domain; Region: T5orf172; pfam10544
365044001436	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
365044001437	non-specific DNA binding site [nucleotide binding]; other site
365044001438	salt bridge; other site
365044001439	sequence-specific DNA binding site [nucleotide binding]; other site
365044001440	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
365044001441	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
365044001442	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365044001443	cofactor binding site; other site
365044001444	DNA binding site [nucleotide binding]
365044001445	substrate interaction site [chemical binding]; other site
365044001446	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
365044001447	Uncharacterized conserved protein [Function unknown]; Region: COG1479
365044001448	Protein of unknown function DUF262; Region: DUF262; pfam03235
365044001449	Predicted transcriptional regulator [Transcription]; Region: COG2932
365044001450	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365044001451	Catalytic site [active]
365044001452	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
365044001453	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001454	AAA domain; Region: AAA_31; pfam13614
365044001455	P-loop; other site
365044001456	Magnesium ion binding site [ion binding]; other site
365044001457	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
365044001458	conjugal transfer protein TraL; Provisional; Region: PRK13886
365044001459	Methyltransferase domain; Region: Methyltransf_26; pfam13659
365044001460	Replication initiator protein A; Region: RPA; pfam10134
365044001461	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
365044001462	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044001463	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365044001464	catalytic residues [active]
365044001465	catalytic nucleophile [active]
365044001466	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044001467	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044001468	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044001469	Synaptic Site I dimer interface [polypeptide binding]; other site
365044001470	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365044001471	DNA-binding interface [nucleotide binding]; DNA binding site
365044001472	replicative DNA helicase; Provisional; Region: PRK05973
365044001473	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
365044001474	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365044001475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001476	non-specific DNA binding site [nucleotide binding]; other site
365044001477	salt bridge; other site
365044001478	sequence-specific DNA binding site [nucleotide binding]; other site
365044001479	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365044001480	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001481	non-specific DNA binding site [nucleotide binding]; other site
365044001482	salt bridge; other site
365044001483	sequence-specific DNA binding site [nucleotide binding]; other site
365044001484	ParA-like protein; Provisional; Region: PHA02518
365044001485	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001486	P-loop; other site
365044001487	Magnesium ion binding site [ion binding]; other site
365044001488	MobA/MobL family; Region: MobA_MobL; pfam03389
365044001489	Domain of unknown function DUF29; Region: DUF29; pfam01724
365044001490	Replication protein C (RepC); Region: RepC; pfam06504
365044001491	AAA domain; Region: AAA_25; pfam13481
365044001492	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044001493	Walker A motif; other site
365044001494	ATP binding site [chemical binding]; other site
365044001495	Walker B motif; other site
365044001496	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
365044001497	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
365044001498	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
365044001499	active site
365044001500	metal binding site [ion binding]; metal-binding site
365044001501	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
365044001502	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
365044001503	NnrU protein; Region: NnrU; pfam07298
365044001504	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
365044001505	cell division topological specificity factor MinE; Provisional; Region: PRK13989
365044001506	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
365044001507	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
365044001508	Switch I; other site
365044001509	Switch II; other site
365044001510	septum formation inhibitor; Reviewed; Region: PRK01973
365044001511	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
365044001512	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
365044001513	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001514	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
365044001515	trimer interface [polypeptide binding]; other site
365044001516	putative Zn binding site [ion binding]; other site
365044001517	Predicted integral membrane protein [Function unknown]; Region: COG0392
365044001518	cardiolipin synthase 2; Provisional; Region: PRK11263
365044001519	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
365044001520	putative active site [active]
365044001521	catalytic site [active]
365044001522	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044001523	putative active site [active]
365044001524	catalytic site [active]
365044001525	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
365044001526	putative catalytic site [active]
365044001527	putative metal binding site [ion binding]; other site
365044001528	putative phosphate binding site [ion binding]; other site
365044001529	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
365044001530	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044001531	LTXXQ motif family protein; Region: LTXXQ; pfam07813
365044001532	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
365044001533	ThiC-associated domain; Region: ThiC-associated; pfam13667
365044001534	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
365044001535	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
365044001536	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
365044001537	thiS-thiF/thiG interaction site; other site
365044001538	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
365044001539	ThiS interaction site; other site
365044001540	putative active site [active]
365044001541	tetramer interface [polypeptide binding]; other site
365044001542	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
365044001543	active site
365044001544	thiamine phosphate binding site [chemical binding]; other site
365044001545	pyrophosphate binding site [ion binding]; other site
365044001546	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
365044001547	Transglycosylase; Region: Transgly; pfam00912
365044001548	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
365044001549	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
365044001550	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
365044001551	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
365044001552	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044001553	metal ion-dependent adhesion site (MIDAS); other site
365044001554	sensory histidine kinase CreC; Provisional; Region: PRK11100
365044001555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001556	dimer interface [polypeptide binding]; other site
365044001557	phosphorylation site [posttranslational modification]
365044001558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001559	ATP binding site [chemical binding]; other site
365044001560	Mg2+ binding site [ion binding]; other site
365044001561	G-X-G motif; other site
365044001562	DNA-binding response regulator CreB; Provisional; Region: PRK11083
365044001563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001564	active site
365044001565	phosphorylation site [posttranslational modification]
365044001566	intermolecular recognition site; other site
365044001567	dimerization interface [polypeptide binding]; other site
365044001568	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044001569	DNA binding site [nucleotide binding]
365044001570	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
365044001571	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
365044001572	FMN binding site [chemical binding]; other site
365044001573	active site
365044001574	substrate binding site [chemical binding]; other site
365044001575	catalytic residue [active]
365044001576	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044001577	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044001578	allophanate hydrolase; Provisional; Region: PRK08186
365044001579	Amidase; Region: Amidase; cl11426
365044001580	urea carboxylase; Region: urea_carbox; TIGR02712
365044001581	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044001582	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365044001583	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
365044001584	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
365044001585	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
365044001586	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044001587	carboxyltransferase (CT) interaction site; other site
365044001588	biotinylation site [posttranslational modification]; other site
365044001589	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
365044001590	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
365044001591	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
365044001592	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
365044001593	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044001594	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
365044001595	Walker A/P-loop; other site
365044001596	ATP binding site [chemical binding]; other site
365044001597	Q-loop/lid; other site
365044001598	ABC transporter signature motif; other site
365044001599	Walker B; other site
365044001600	D-loop; other site
365044001601	H-loop/switch region; other site
365044001602	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044001603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044001604	dimer interface [polypeptide binding]; other site
365044001605	conserved gate region; other site
365044001606	putative PBP binding loops; other site
365044001607	ABC-ATPase subunit interface; other site
365044001608	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
365044001609	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044001610	ykkC-yxkD element as predicted by Rfam (RF00442), score 69.07
365044001611	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
365044001612	active site
365044001613	dimer interfaces [polypeptide binding]; other site
365044001614	catalytic residues [active]
365044001615	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044001616	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044001617	DctM-like transporters; Region: DctM; pfam06808
365044001618	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
365044001619	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
365044001620	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
365044001621	ATP-binding site [chemical binding]; other site
365044001622	Gluconate-6-phosphate binding site [chemical binding]; other site
365044001623	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044001624	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044001625	DNA binding site [nucleotide binding]
365044001626	domain linker motif; other site
365044001627	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
365044001628	putative ligand binding site [chemical binding]; other site
365044001629	putative dimerization interface [polypeptide binding]; other site
365044001630	Ferredoxin [Energy production and conversion]; Region: COG1146
365044001631	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
365044001632	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
365044001633	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
365044001634	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
365044001635	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
365044001636	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044001637	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044001638	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
365044001639	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
365044001640	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
365044001641	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
365044001642	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
365044001643	CoA binding domain; Region: CoA_binding_2; pfam13380
365044001644	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
365044001645	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
365044001646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365044001647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044001648	Coenzyme A binding pocket [chemical binding]; other site
365044001649	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
365044001650	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
365044001651	putative active site [active]
365044001652	Zn binding site [ion binding]; other site
365044001653	beta-ketothiolase; Provisional; Region: PRK09051
365044001654	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044001655	dimer interface [polypeptide binding]; other site
365044001656	active site
365044001657	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
365044001658	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044001659	putative active site [active]
365044001660	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
365044001661	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
365044001662	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
365044001663	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
365044001664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044001665	S-adenosylmethionine binding site [chemical binding]; other site
365044001666	LysE type translocator; Region: LysE; cl00565
365044001667	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
365044001668	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044001669	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001670	Magnesium ion binding site [ion binding]; other site
365044001671	Serine hydrolase; Region: Ser_hydrolase; pfam06821
365044001672	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044001673	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
365044001674	ParB-like nuclease domain; Region: ParB; smart00470
365044001675	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044001676	FAD binding domain; Region: FAD_binding_4; pfam01565
365044001677	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
365044001678	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
365044001679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044001680	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
365044001681	substrate binding site [chemical binding]; other site
365044001682	dimerization interface [polypeptide binding]; other site
365044001683	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
365044001684	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
365044001685	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
365044001686	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
365044001687	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
365044001688	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
365044001689	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044001690	ATP binding site [chemical binding]; other site
365044001691	Walker A motif; other site
365044001692	Walker B motif; other site
365044001693	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044001694	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044001695	Probable transposase; Region: OrfB_IS605; pfam01385
365044001696	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044001697	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044001698	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044001699	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
365044001700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044001701	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
365044001702	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
365044001703	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044001704	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044001705	Walker A/P-loop; other site
365044001706	ATP binding site [chemical binding]; other site
365044001707	Q-loop/lid; other site
365044001708	ABC transporter signature motif; other site
365044001709	Walker B; other site
365044001710	D-loop; other site
365044001711	H-loop/switch region; other site
365044001712	Haemolytic domain; Region: Haemolytic; cl00506
365044001713	Uncharacterized conserved protein [Function unknown]; Region: COG3025
365044001714	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
365044001715	putative active site [active]
365044001716	putative metal binding residues [ion binding]; other site
365044001717	signature motif; other site
365044001718	putative triphosphate binding site [ion binding]; other site
365044001719	CHAD domain; Region: CHAD; pfam05235
365044001720	PAS fold; Region: PAS_4; pfam08448
365044001721	PAS fold; Region: PAS_4; pfam08448
365044001722	PAS domain; Region: PAS_9; pfam13426
365044001723	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001724	PAS fold; Region: PAS_3; pfam08447
365044001725	putative active site [active]
365044001726	heme pocket [chemical binding]; other site
365044001727	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044001728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001729	dimer interface [polypeptide binding]; other site
365044001730	phosphorylation site [posttranslational modification]
365044001731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001732	ATP binding site [chemical binding]; other site
365044001733	G-X-G motif; other site
365044001734	Response regulator receiver domain; Region: Response_reg; pfam00072
365044001735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001736	active site
365044001737	phosphorylation site [posttranslational modification]
365044001738	intermolecular recognition site; other site
365044001739	dimerization interface [polypeptide binding]; other site
365044001740	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
365044001741	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
365044001742	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044001743	hydroxyglutarate oxidase; Provisional; Region: PRK11728
365044001744	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
365044001745	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044001746	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044001747	dimerization interface [polypeptide binding]; other site
365044001748	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044001749	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
365044001750	putative ligand binding site [chemical binding]; other site
365044001751	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044001752	dimerization interface [polypeptide binding]; other site
365044001753	PAS fold; Region: PAS; pfam00989
365044001754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001755	putative active site [active]
365044001756	heme pocket [chemical binding]; other site
365044001757	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044001758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001759	PAS fold; Region: PAS_3; pfam08447
365044001760	putative active site [active]
365044001761	heme pocket [chemical binding]; other site
365044001762	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044001763	GAF domain; Region: GAF; pfam01590
365044001764	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044001765	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001766	dimer interface [polypeptide binding]; other site
365044001767	phosphorylation site [posttranslational modification]
365044001768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001769	ATP binding site [chemical binding]; other site
365044001770	Mg2+ binding site [ion binding]; other site
365044001771	G-X-G motif; other site
365044001772	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044001773	Ligand Binding Site [chemical binding]; other site
365044001774	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001775	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044001776	active site
365044001777	metal binding site [ion binding]; metal-binding site
365044001778	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001779	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
365044001780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044001781	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
365044001782	substrate binding pocket [chemical binding]; other site
365044001783	dimerization interface [polypeptide binding]; other site
365044001784	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
365044001785	active site
365044001786	substrate-binding site [chemical binding]; other site
365044001787	metal-binding site [ion binding]
365044001788	GTP binding site [chemical binding]; other site
365044001789	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044001790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001791	active site
365044001792	phosphorylation site [posttranslational modification]
365044001793	intermolecular recognition site; other site
365044001794	dimerization interface [polypeptide binding]; other site
365044001795	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044001796	DNA binding residues [nucleotide binding]
365044001797	dimerization interface [polypeptide binding]; other site
365044001798	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044001799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001800	dimer interface [polypeptide binding]; other site
365044001801	phosphorylation site [posttranslational modification]
365044001802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001803	ATP binding site [chemical binding]; other site
365044001804	Mg2+ binding site [ion binding]; other site
365044001805	G-X-G motif; other site
365044001806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001807	active site
365044001808	phosphorylation site [posttranslational modification]
365044001809	intermolecular recognition site; other site
365044001810	dimerization interface [polypeptide binding]; other site
365044001811	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044001812	Walker A/P-loop; other site
365044001813	ATP binding site [chemical binding]; other site
365044001814	ABC transporter; Region: ABC_tran; pfam00005
365044001815	Q-loop/lid; other site
365044001816	ABC transporter signature motif; other site
365044001817	Walker B; other site
365044001818	D-loop; other site
365044001819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
365044001820	MOSC domain; Region: MOSC; pfam03473
365044001821	threonine dehydratase; Provisional; Region: PRK07334
365044001822	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
365044001823	tetramer interface [polypeptide binding]; other site
365044001824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044001825	catalytic residue [active]
365044001826	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
365044001827	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
365044001828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001829	Walker A motif; other site
365044001830	ATP binding site [chemical binding]; other site
365044001831	Walker B motif; other site
365044001832	arginine finger; other site
365044001833	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001834	Walker A motif; other site
365044001835	ATP binding site [chemical binding]; other site
365044001836	Walker B motif; other site
365044001837	arginine finger; other site
365044001838	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
365044001839	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044001840	ATP binding site [chemical binding]; other site
365044001841	putative Mg++ binding site [ion binding]; other site
365044001842	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044001843	nucleotide binding region [chemical binding]; other site
365044001844	ATP-binding site [chemical binding]; other site
365044001845	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
365044001846	HRDC domain; Region: HRDC; pfam00570
365044001847	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
365044001848	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
365044001849	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044001850	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044001851	ligand binding site [chemical binding]; other site
365044001852	flexible hinge region; other site
365044001853	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
365044001854	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
365044001855	substrate binding pocket [chemical binding]; other site
365044001856	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
365044001857	B12 binding site [chemical binding]; other site
365044001858	cobalt ligand [ion binding]; other site
365044001859	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
365044001860	Uncharacterized conserved protein [Function unknown]; Region: COG3391
365044001861	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
365044001862	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
365044001863	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
365044001864	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
365044001865	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
365044001866	Nitrogen regulatory protein P-II; Region: P-II; smart00938
365044001867	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
365044001868	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
365044001869	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
365044001870	FAD binding domain; Region: FAD_binding_4; pfam01565
365044001871	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
365044001872	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
365044001873	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044001874	Cysteine-rich domain; Region: CCG; pfam02754
365044001875	Cysteine-rich domain; Region: CCG; pfam02754
365044001876	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
365044001877	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
365044001878	catalytic residues [active]
365044001879	dimer interface [polypeptide binding]; other site
365044001880	EamA-like transporter family; Region: EamA; pfam00892
365044001881	lysophospholipid transporter LplT; Provisional; Region: PRK11195
365044001882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044001883	alanine racemase; Reviewed; Region: dadX; PRK03646
365044001884	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
365044001885	active site
365044001886	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044001887	substrate binding site [chemical binding]; other site
365044001888	catalytic residues [active]
365044001889	dimer interface [polypeptide binding]; other site
365044001890	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365044001891	active site
365044001892	NTP binding site [chemical binding]; other site
365044001893	metal binding triad [ion binding]; metal-binding site
365044001894	antibiotic binding site [chemical binding]; other site
365044001895	Protein of unknown function DUF86; Region: DUF86; pfam01934
365044001896	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044001897	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
365044001898	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044001899	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044001900	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
365044001901	putative substrate binding pocket [chemical binding]; other site
365044001902	trimer interface [polypeptide binding]; other site
365044001903	DNA repair protein RadA; Provisional; Region: PRK11823
365044001904	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
365044001905	Walker A motif/ATP binding site; other site
365044001906	ATP binding site [chemical binding]; other site
365044001907	Walker B motif; other site
365044001908	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
365044001909	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
365044001910	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044001911	active site
365044001912	metal binding site [ion binding]; metal-binding site
365044001913	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044001914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044001915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044001916	Spore Coat Protein U domain; Region: SCPU; pfam05229
365044001917	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
365044001918	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
365044001919	PapC C-terminal domain; Region: PapC_C; pfam13953
365044001920	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
365044001921	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
365044001922	Spore Coat Protein U domain; Region: SCPU; pfam05229
365044001923	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
365044001924	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
365044001925	homodimer interface [polypeptide binding]; other site
365044001926	substrate-cofactor binding pocket; other site
365044001927	catalytic residue [active]
365044001928	Zinc-finger domain; Region: zf-CHCC; cl01821
365044001929	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
365044001930	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
365044001931	putative active site [active]
365044001932	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044001933	dimerization interface [polypeptide binding]; other site
365044001934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001935	dimer interface [polypeptide binding]; other site
365044001936	phosphorylation site [posttranslational modification]
365044001937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001938	ATP binding site [chemical binding]; other site
365044001939	G-X-G motif; other site
365044001940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044001941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001942	active site
365044001943	phosphorylation site [posttranslational modification]
365044001944	intermolecular recognition site; other site
365044001945	dimerization interface [polypeptide binding]; other site
365044001946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044001947	DNA binding site [nucleotide binding]
365044001948	AmpG-like permease; Region: 2A0125; TIGR00901
365044001949	Peptidase family M48; Region: Peptidase_M48; pfam01435
365044001950	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
365044001951	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
365044001952	NAD(P) binding site [chemical binding]; other site
365044001953	catalytic residues [active]
365044001954	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
365044001955	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
365044001956	FMN binding site [chemical binding]; other site
365044001957	active site
365044001958	substrate binding site [chemical binding]; other site
365044001959	catalytic residue [active]
365044001960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044001961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044001962	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
365044001963	ATP binding site [chemical binding]; other site
365044001964	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365044001965	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
365044001966	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044001967	Walker A/P-loop; other site
365044001968	ATP binding site [chemical binding]; other site
365044001969	Q-loop/lid; other site
365044001970	ABC transporter signature motif; other site
365044001971	Walker B; other site
365044001972	D-loop; other site
365044001973	H-loop/switch region; other site
365044001974	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
365044001975	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001976	PAS domain; Region: PAS_9; pfam13426
365044001977	putative active site [active]
365044001978	heme pocket [chemical binding]; other site
365044001979	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044001980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001981	putative active site [active]
365044001982	heme pocket [chemical binding]; other site
365044001983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001984	dimer interface [polypeptide binding]; other site
365044001985	phosphorylation site [posttranslational modification]
365044001986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001987	ATP binding site [chemical binding]; other site
365044001988	Mg2+ binding site [ion binding]; other site
365044001989	G-X-G motif; other site
365044001990	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
365044001991	putative active site [active]
365044001992	putative catalytic site [active]
365044001993	putative DNA binding site [nucleotide binding]; other site
365044001994	putative phosphate binding site [ion binding]; other site
365044001995	metal binding site A [ion binding]; metal-binding site
365044001996	putative AP binding site [nucleotide binding]; other site
365044001997	putative metal binding site B [ion binding]; other site
365044001998	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044001999	active site
365044002000	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
365044002001	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
365044002002	GatB domain; Region: GatB_Yqey; smart00845
365044002003	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
365044002004	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
365044002005	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
365044002006	rod shape-determining protein MreB; Provisional; Region: PRK13927
365044002007	MreB and similar proteins; Region: MreB_like; cd10225
365044002008	nucleotide binding site [chemical binding]; other site
365044002009	Mg binding site [ion binding]; other site
365044002010	putative protofilament interaction site [polypeptide binding]; other site
365044002011	RodZ interaction site [polypeptide binding]; other site
365044002012	rod shape-determining protein MreC; Provisional; Region: PRK13922
365044002013	rod shape-determining protein MreC; Region: MreC; pfam04085
365044002014	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
365044002015	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
365044002016	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365044002017	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
365044002018	hypothetical protein; Provisional; Region: PRK10621
365044002019	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
365044002020	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
365044002021	choline dehydrogenase; Validated; Region: PRK02106
365044002022	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
365044002023	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044002024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044002025	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044002026	dimerization interface [polypeptide binding]; other site
365044002027	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
365044002028	Permease; Region: Permease; pfam02405
365044002029	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
365044002030	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
365044002031	Walker A/P-loop; other site
365044002032	ATP binding site [chemical binding]; other site
365044002033	Q-loop/lid; other site
365044002034	ABC transporter signature motif; other site
365044002035	Walker B; other site
365044002036	D-loop; other site
365044002037	H-loop/switch region; other site
365044002038	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
365044002039	mce related protein; Region: MCE; pfam02470
365044002040	MarC family integral membrane protein; Region: MarC; cl00919
365044002041	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
365044002042	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
365044002043	putative catalytic residue [active]
365044002044	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
365044002045	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
365044002046	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
365044002047	Protein of unknown function DUF72; Region: DUF72; pfam01904
365044002048	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
365044002049	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
365044002050	oligomer interface [polypeptide binding]; other site
365044002051	metal binding site [ion binding]; metal-binding site
365044002052	metal binding site [ion binding]; metal-binding site
365044002053	putative Cl binding site [ion binding]; other site
365044002054	aspartate ring; other site
365044002055	basic sphincter; other site
365044002056	hydrophobic gate; other site
365044002057	periplasmic entrance; other site
365044002058	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
365044002059	dimer interface [polypeptide binding]; other site
365044002060	allosteric magnesium binding site [ion binding]; other site
365044002061	active site
365044002062	aspartate-rich active site metal binding site; other site
365044002063	Schiff base residues; other site
365044002064	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
365044002065	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
365044002066	dimer interface [polypeptide binding]; other site
365044002067	[2Fe-2S] cluster binding site [ion binding]; other site
365044002068	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
365044002069	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
365044002070	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
365044002071	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
365044002072	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
365044002073	S17 interaction site [polypeptide binding]; other site
365044002074	S8 interaction site; other site
365044002075	16S rRNA interaction site [nucleotide binding]; other site
365044002076	streptomycin interaction site [chemical binding]; other site
365044002077	23S rRNA interaction site [nucleotide binding]; other site
365044002078	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
365044002079	30S ribosomal protein S7; Validated; Region: PRK05302
365044002080	elongation factor G; Reviewed; Region: PRK00007
365044002081	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
365044002082	G1 box; other site
365044002083	putative GEF interaction site [polypeptide binding]; other site
365044002084	GTP/Mg2+ binding site [chemical binding]; other site
365044002085	Switch I region; other site
365044002086	G2 box; other site
365044002087	G3 box; other site
365044002088	Switch II region; other site
365044002089	G4 box; other site
365044002090	G5 box; other site
365044002091	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
365044002092	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
365044002093	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
365044002094	elongation factor Tu; Reviewed; Region: PRK00049
365044002095	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
365044002096	G1 box; other site
365044002097	GEF interaction site [polypeptide binding]; other site
365044002098	GTP/Mg2+ binding site [chemical binding]; other site
365044002099	Switch I region; other site
365044002100	G2 box; other site
365044002101	G3 box; other site
365044002102	Switch II region; other site
365044002103	G4 box; other site
365044002104	G5 box; other site
365044002105	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
365044002106	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
365044002107	Antibiotic Binding Site [chemical binding]; other site
365044002108	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
365044002109	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
365044002110	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
365044002111	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
365044002112	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
365044002113	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
365044002114	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
365044002115	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
365044002116	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
365044002117	putative translocon binding site; other site
365044002118	protein-rRNA interface [nucleotide binding]; other site
365044002119	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
365044002120	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
365044002121	G-X-X-G motif; other site
365044002122	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
365044002123	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
365044002124	23S rRNA interface [nucleotide binding]; other site
365044002125	5S rRNA interface [nucleotide binding]; other site
365044002126	putative antibiotic binding site [chemical binding]; other site
365044002127	L25 interface [polypeptide binding]; other site
365044002128	L27 interface [polypeptide binding]; other site
365044002129	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
365044002130	23S rRNA interface [nucleotide binding]; other site
365044002131	putative translocon interaction site; other site
365044002132	signal recognition particle (SRP54) interaction site; other site
365044002133	L23 interface [polypeptide binding]; other site
365044002134	trigger factor interaction site; other site
365044002135	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
365044002136	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
365044002137	catalytic triad [active]
365044002138	dimer interface [polypeptide binding]; other site
365044002139	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044002140	Coenzyme A binding pocket [chemical binding]; other site
365044002141	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044002142	Cytochrome C' Region: Cytochrom_C_2; pfam01322
365044002143	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044002144	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365044002145	catalytic residues [active]
365044002146	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
365044002147	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
365044002148	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365044002149	homodimer interface [polypeptide binding]; other site
365044002150	substrate-cofactor binding pocket; other site
365044002151	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002152	catalytic residue [active]
365044002153	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
365044002154	Protein of unknown function (DUF445); Region: DUF445; pfam04286
365044002155	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
365044002156	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044002157	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044002158	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044002159	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044002160	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044002161	DNA binding site [nucleotide binding]
365044002162	domain linker motif; other site
365044002163	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
365044002164	ligand binding site [chemical binding]; other site
365044002165	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044002166	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044002167	DNA binding site [nucleotide binding]
365044002168	domain linker motif; other site
365044002169	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
365044002170	putative dimerization interface [polypeptide binding]; other site
365044002171	putative ligand binding site [chemical binding]; other site
365044002172	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044002173	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
365044002174	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044002175	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
365044002176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044002177	putative PBP binding loops; other site
365044002178	ABC-ATPase subunit interface; other site
365044002179	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
365044002180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044002181	dimer interface [polypeptide binding]; other site
365044002182	conserved gate region; other site
365044002183	putative PBP binding loops; other site
365044002184	ABC-ATPase subunit interface; other site
365044002185	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
365044002186	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
365044002187	Walker A/P-loop; other site
365044002188	ATP binding site [chemical binding]; other site
365044002189	Q-loop/lid; other site
365044002190	ABC transporter signature motif; other site
365044002191	Walker B; other site
365044002192	D-loop; other site
365044002193	H-loop/switch region; other site
365044002194	TOBE domain; Region: TOBE_2; pfam08402
365044002195	sucrose phosphorylase; Provisional; Region: PRK13840
365044002196	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
365044002197	active site
365044002198	homodimer interface [polypeptide binding]; other site
365044002199	catalytic site [active]
365044002200	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044002201	Ligand Binding Site [chemical binding]; other site
365044002202	Dodecin; Region: Dodecin; pfam07311
365044002203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044002204	putative substrate translocation pore; other site
365044002205	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044002206	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
365044002207	active pocket/dimerization site; other site
365044002208	active site
365044002209	phosphorylation site [posttranslational modification]
365044002210	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
365044002211	dimerization domain swap beta strand [polypeptide binding]; other site
365044002212	regulatory protein interface [polypeptide binding]; other site
365044002213	active site
365044002214	regulatory phosphorylation site [posttranslational modification]; other site
365044002215	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
365044002216	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
365044002217	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
365044002218	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
365044002219	EamA-like transporter family; Region: EamA; pfam00892
365044002220	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044002221	lipoyl synthase; Provisional; Region: PRK05481
365044002222	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044002223	FeS/SAM binding site; other site
365044002224	lipoate-protein ligase B; Provisional; Region: PRK14346
365044002225	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
365044002226	Protein of unknown function (DUF493); Region: DUF493; cl01102
365044002227	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
365044002228	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
365044002229	homodimer interface [polypeptide binding]; other site
365044002230	substrate-cofactor binding pocket; other site
365044002231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002232	catalytic residue [active]
365044002233	ATP synthase I chain; Region: ATP_synt_I; pfam03899
365044002234	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
365044002235	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
365044002236	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
365044002237	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
365044002238	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
365044002239	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
365044002240	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
365044002241	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
365044002242	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365044002243	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
365044002244	beta subunit interaction interface [polypeptide binding]; other site
365044002245	Walker A motif; other site
365044002246	ATP binding site [chemical binding]; other site
365044002247	Walker B motif; other site
365044002248	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044002249	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
365044002250	core domain interface [polypeptide binding]; other site
365044002251	delta subunit interface [polypeptide binding]; other site
365044002252	epsilon subunit interface [polypeptide binding]; other site
365044002253	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
365044002254	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365044002255	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
365044002256	alpha subunit interaction interface [polypeptide binding]; other site
365044002257	Walker A motif; other site
365044002258	ATP binding site [chemical binding]; other site
365044002259	Walker B motif; other site
365044002260	inhibitor binding site; inhibition site
365044002261	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044002262	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
365044002263	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
365044002264	gamma subunit interface [polypeptide binding]; other site
365044002265	epsilon subunit interface [polypeptide binding]; other site
365044002266	LBP interface [polypeptide binding]; other site
365044002267	Repair protein; Region: Repair_PSII; pfam04536
365044002268	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
365044002269	Repair protein; Region: Repair_PSII; pfam04536
365044002270	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
365044002271	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
365044002272	SnoaL-like domain; Region: SnoaL_3; pfam13474
365044002273	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
365044002274	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
365044002275	Cytochrome c; Region: Cytochrom_C; cl11414
365044002276	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
365044002277	High potential iron-sulfur protein; Region: HIPIP; pfam01355
365044002278	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044002279	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044002280	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
365044002281	acyl-activating enzyme (AAE) consensus motif; other site
365044002282	putative AMP binding site [chemical binding]; other site
365044002283	putative active site [active]
365044002284	putative CoA binding site [chemical binding]; other site
365044002285	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
365044002286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044002287	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
365044002288	putative substrate translocation pore; other site
365044002289	Predicted methyltransferases [General function prediction only]; Region: COG0313
365044002290	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
365044002291	putative SAM binding site [chemical binding]; other site
365044002292	putative homodimer interface [polypeptide binding]; other site
365044002293	hypothetical protein; Provisional; Region: PRK14673
365044002294	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
365044002295	dimer interface [polypeptide binding]; other site
365044002296	active site
365044002297	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
365044002298	BON domain; Region: BON; pfam04972
365044002299	BON domain; Region: BON; pfam04972
365044002300	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
365044002301	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
365044002302	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
365044002303	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044002304	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044002305	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044002306	ligand binding site [chemical binding]; other site
365044002307	flexible hinge region; other site
365044002308	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
365044002309	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
365044002310	Walker A motif; other site
365044002311	ATP binding site [chemical binding]; other site
365044002312	Walker B motif; other site
365044002313	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044002314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044002315	Probable transposase; Region: OrfB_IS605; pfam01385
365044002316	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044002317	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
365044002318	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044002319	catalytic residue [active]
365044002320	PAS fold; Region: PAS_3; pfam08447
365044002321	PAS fold; Region: PAS_4; pfam08448
365044002322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002323	putative active site [active]
365044002324	heme pocket [chemical binding]; other site
365044002325	PAS domain; Region: PAS_9; pfam13426
365044002326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002327	putative active site [active]
365044002328	heme pocket [chemical binding]; other site
365044002329	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
365044002330	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
365044002331	metal binding site [ion binding]; metal-binding site
365044002332	active site
365044002333	I-site; other site
365044002334	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
365044002335	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
365044002336	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
365044002337	DXD motif; other site
365044002338	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
365044002339	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
365044002340	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312
365044002341	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
365044002342	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
365044002343	LrgA family; Region: LrgA; pfam03788
365044002344	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
365044002345	FAD binding domain; Region: FAD_binding_4; pfam01565
365044002346	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
365044002347	putative active site [active]
365044002348	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
365044002349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044002350	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
365044002351	dimerization interface [polypeptide binding]; other site
365044002352	substrate binding pocket [chemical binding]; other site
365044002353	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
365044002354	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
365044002355	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
365044002356	putative active site [active]
365044002357	putative substrate binding site [chemical binding]; other site
365044002358	putative cosubstrate binding site; other site
365044002359	catalytic site [active]
365044002360	Protein of unknown function, DUF399; Region: DUF399; pfam04187
365044002361	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044002362	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044002363	putative ligand binding site [chemical binding]; other site
365044002364	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
365044002365	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
365044002366	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044002367	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044002368	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
365044002369	putative active site [active]
365044002370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
365044002371	FIST N domain; Region: FIST; smart00897
365044002372	FIST C domain; Region: FIST_C; pfam10442
365044002373	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044002374	non-specific DNA binding site [nucleotide binding]; other site
365044002375	salt bridge; other site
365044002376	sequence-specific DNA binding site [nucleotide binding]; other site
365044002377	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
365044002378	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044002379	putative acyl-acceptor binding pocket; other site
365044002380	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
365044002381	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
365044002382	yiaA/B two helix domain; Region: YiaAB; cl01759
365044002383	Double zinc ribbon; Region: DZR; pfam12773
365044002384	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
365044002385	Predicted membrane protein [Function unknown]; Region: COG2246
365044002386	GtrA-like protein; Region: GtrA; pfam04138
365044002387	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
365044002388	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365044002389	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
365044002390	putative active site [active]
365044002391	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
365044002392	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
365044002393	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
365044002394	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
365044002395	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
365044002396	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
365044002397	generic binding surface II; other site
365044002398	ssDNA binding site; other site
365044002399	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044002400	putative Mg++ binding site [ion binding]; other site
365044002401	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044002402	nucleotide binding region [chemical binding]; other site
365044002403	ATP-binding site [chemical binding]; other site
365044002404	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
365044002405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044002406	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
365044002407	dimerization interface [polypeptide binding]; other site
365044002408	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
365044002409	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
365044002410	dimerization interface [polypeptide binding]; other site
365044002411	DPS ferroxidase diiron center [ion binding]; other site
365044002412	ion pore; other site
365044002413	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
365044002414	UbiA prenyltransferase family; Region: UbiA; pfam01040
365044002415	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
365044002416	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
365044002417	glycerol kinase; Provisional; Region: glpK; PRK00047
365044002418	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
365044002419	N- and C-terminal domain interface [polypeptide binding]; other site
365044002420	active site
365044002421	MgATP binding site [chemical binding]; other site
365044002422	catalytic site [active]
365044002423	metal binding site [ion binding]; metal-binding site
365044002424	glycerol binding site [chemical binding]; other site
365044002425	homotetramer interface [polypeptide binding]; other site
365044002426	homodimer interface [polypeptide binding]; other site
365044002427	FBP binding site [chemical binding]; other site
365044002428	protein IIAGlc interface [polypeptide binding]; other site
365044002429	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
365044002430	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
365044002431	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
365044002432	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
365044002433	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
365044002434	RNA binding site [nucleotide binding]; other site
365044002435	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
365044002436	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
365044002437	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
365044002438	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
365044002439	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
365044002440	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
365044002441	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
365044002442	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
365044002443	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
365044002444	5S rRNA interface [nucleotide binding]; other site
365044002445	23S rRNA interface [nucleotide binding]; other site
365044002446	L5 interface [polypeptide binding]; other site
365044002447	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
365044002448	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
365044002449	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
365044002450	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
365044002451	23S rRNA binding site [nucleotide binding]; other site
365044002452	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
365044002453	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
365044002454	SecY translocase; Region: SecY; pfam00344
365044002455	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
365044002456	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
365044002457	30S ribosomal protein S13; Region: bact_S13; TIGR03631
365044002458	30S ribosomal protein S11; Validated; Region: PRK05309
365044002459	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
365044002460	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
365044002461	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044002462	RNA binding surface [nucleotide binding]; other site
365044002463	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
365044002464	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
365044002465	alphaNTD homodimer interface [polypeptide binding]; other site
365044002466	alphaNTD - beta interaction site [polypeptide binding]; other site
365044002467	alphaNTD - beta' interaction site [polypeptide binding]; other site
365044002468	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
365044002469	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
365044002470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044002471	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044002472	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044002473	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
365044002474	Phospholipase A1; Region: PLA1; pfam02253
365044002475	substrate binding site [chemical binding]; other site
365044002476	dimerization interface [polypeptide binding]; other site
365044002477	active site
365044002478	calcium binding site [ion binding]; other site
365044002479	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
365044002480	Part of AAA domain; Region: AAA_19; pfam13245
365044002481	Family description; Region: UvrD_C_2; pfam13538
365044002482	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
365044002483	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
365044002484	metal binding site [ion binding]; metal-binding site
365044002485	putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590
365044002486	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
365044002487	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
365044002488	active site
365044002489	metal binding site [ion binding]; metal-binding site
365044002490	dimer interface [polypeptide binding]; other site
365044002491	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
365044002492	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
365044002493	active site
365044002494	catalytic site [active]
365044002495	tetramer interface [polypeptide binding]; other site
365044002496	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
365044002497	active site
365044002498	homotetramer interface [polypeptide binding]; other site
365044002499	Protein of unknown function (DUF989); Region: DUF989; pfam06181
365044002500	Predicted membrane protein [Function unknown]; Region: COG3748
365044002501	Cytochrome c; Region: Cytochrom_C; pfam00034
365044002502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002503	Walker A motif; other site
365044002504	ATP binding site [chemical binding]; other site
365044002505	Walker B motif; other site
365044002506	arginine finger; other site
365044002507	PAS domain S-box; Region: sensory_box; TIGR00229
365044002508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002509	putative active site [active]
365044002510	heme pocket [chemical binding]; other site
365044002511	PAS domain; Region: PAS_9; pfam13426
365044002512	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
365044002513	PAS fold; Region: PAS_4; pfam08448
365044002514	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002515	putative active site [active]
365044002516	heme pocket [chemical binding]; other site
365044002517	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044002518	PAS domain; Region: PAS; smart00091
365044002519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002520	putative active site [active]
365044002521	heme pocket [chemical binding]; other site
365044002522	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002523	dimer interface [polypeptide binding]; other site
365044002524	phosphorylation site [posttranslational modification]
365044002525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002526	ATP binding site [chemical binding]; other site
365044002527	Mg2+ binding site [ion binding]; other site
365044002528	G-X-G motif; other site
365044002529	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
365044002530	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
365044002531	primosome assembly protein PriA; Validated; Region: PRK05580
365044002532	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044002533	ATP binding site [chemical binding]; other site
365044002534	putative Mg++ binding site [ion binding]; other site
365044002535	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
365044002536	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
365044002537	substrate binding site [chemical binding]; other site
365044002538	active site
365044002539	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
365044002540	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
365044002541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044002542	Walker A/P-loop; other site
365044002543	ATP binding site [chemical binding]; other site
365044002544	Q-loop/lid; other site
365044002545	ABC transporter signature motif; other site
365044002546	Walker B; other site
365044002547	D-loop; other site
365044002548	H-loop/switch region; other site
365044002549	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
365044002550	active site
365044002551	catalytic residues [active]
365044002552	active site
365044002553	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
365044002554	G1 box; other site
365044002555	GTP/Mg2+ binding site [chemical binding]; other site
365044002556	G2 box; other site
365044002557	Switch I region; other site
365044002558	G3 box; other site
365044002559	Switch II region; other site
365044002560	G4 box; other site
365044002561	G5 box; other site
365044002562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044002563	S-adenosylmethionine binding site [chemical binding]; other site
365044002564	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365044002565	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
365044002566	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
365044002567	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
365044002568	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
365044002569	DsbD alpha interface [polypeptide binding]; other site
365044002570	catalytic residues [active]
365044002571	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044002572	non-specific DNA binding site [nucleotide binding]; other site
365044002573	salt bridge; other site
365044002574	sequence-specific DNA binding site [nucleotide binding]; other site
365044002575	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
365044002576	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
365044002577	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044002578	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
365044002579	Helix-turn-helix domain; Region: HTH_36; pfam13730
365044002580	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365044002581	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044002582	putative active site [active]
365044002583	putative NTP binding site [chemical binding]; other site
365044002584	putative nucleic acid binding site [nucleotide binding]; other site
365044002585	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044002586	salt bridge; other site
365044002587	non-specific DNA binding site [nucleotide binding]; other site
365044002588	sequence-specific DNA binding site [nucleotide binding]; other site
365044002589	B12 binding domain; Region: B12-binding; pfam02310
365044002590	B12 binding site [chemical binding]; other site
365044002591	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
365044002592	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044002593	FeS/SAM binding site; other site
365044002594	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
365044002595	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
365044002596	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
365044002597	ring oligomerisation interface [polypeptide binding]; other site
365044002598	ATP/Mg binding site [chemical binding]; other site
365044002599	stacking interactions; other site
365044002600	hinge regions; other site
365044002601	Protein required for attachment to host cells; Region: Host_attach; pfam10116
365044002602	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044002603	Ligand Binding Site [chemical binding]; other site
365044002604	FtsH Extracellular; Region: FtsH_ext; pfam06480
365044002605	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
365044002606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002607	Walker A motif; other site
365044002608	ATP binding site [chemical binding]; other site
365044002609	Walker B motif; other site
365044002610	arginine finger; other site
365044002611	Peptidase family M41; Region: Peptidase_M41; pfam01434
365044002612	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
365044002613	Creatinine amidohydrolase; Region: Creatininase; pfam02633
365044002614	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
365044002615	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044002616	catalytic core [active]
365044002617	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044002618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002619	dimer interface [polypeptide binding]; other site
365044002620	phosphorylation site [posttranslational modification]
365044002621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002622	ATP binding site [chemical binding]; other site
365044002623	Mg2+ binding site [ion binding]; other site
365044002624	G-X-G motif; other site
365044002625	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002627	active site
365044002628	phosphorylation site [posttranslational modification]
365044002629	intermolecular recognition site; other site
365044002630	dimerization interface [polypeptide binding]; other site
365044002631	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044002632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
365044002633	active site
365044002634	phosphorylation site [posttranslational modification]
365044002635	intermolecular recognition site; other site
365044002636	dimerization interface [polypeptide binding]; other site
365044002637	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
365044002638	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
365044002639	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044002640	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002641	homodimer interface [polypeptide binding]; other site
365044002642	catalytic residue [active]
365044002643	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
365044002644	EamA-like transporter family; Region: EamA; pfam00892
365044002645	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044002646	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044002647	DNA-binding site [nucleotide binding]; DNA binding site
365044002648	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044002649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002650	homodimer interface [polypeptide binding]; other site
365044002651	catalytic residue [active]
365044002652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
365044002653	conserved repeat domain; Region: B_ant_repeat; TIGR01451
365044002654	Calx-beta domain; Region: Calx-beta; cl02522
365044002655	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044002656	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044002657	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044002658	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
365044002659	PLD-like domain; Region: PLDc_2; pfam13091
365044002660	putative active site [active]
365044002661	catalytic site [active]
365044002662	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
365044002663	PLD-like domain; Region: PLDc_2; pfam13091
365044002664	putative active site [active]
365044002665	catalytic site [active]
365044002666	ABC transporter ATPase component; Reviewed; Region: PRK11147
365044002667	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365044002668	Walker A/P-loop; other site
365044002669	ATP binding site [chemical binding]; other site
365044002670	Q-loop/lid; other site
365044002671	ABC transporter signature motif; other site
365044002672	Walker B; other site
365044002673	D-loop; other site
365044002674	H-loop/switch region; other site
365044002675	ABC transporter; Region: ABC_tran_2; pfam12848
365044002676	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365044002677	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044002678	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044002679	catalytic residues [active]
365044002680	catalytic nucleophile [active]
365044002681	Recombinase; Region: Recombinase; pfam07508
365044002682	Helix-turn-helix domain; Region: HTH_17; pfam12728
365044002683	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044002684	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044002685	Winged helix-turn helix; Region: HTH_29; pfam13551
365044002686	Winged helix-turn helix; Region: HTH_33; pfam13592
365044002687	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044002688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044002689	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044002690	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044002691	Mediator complex subunit 23; Region: Med23; pfam11573
365044002692	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044002693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044002694	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044002695	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044002696	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365044002697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044002698	Transposase; Region: HTH_Tnp_1; cl17663
365044002699	Transposase domain (DUF772); Region: DUF772; pfam05598
365044002700	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
365044002701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044002702	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044002703	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044002704	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044002705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044002706	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044002707	DDE superfamily endonuclease; Region: DDE_5; cl17874
365044002708	HTH-like domain; Region: HTH_21; pfam13276
365044002709	Integrase core domain; Region: rve; pfam00665
365044002710	Integrase core domain; Region: rve_3; pfam13683
365044002711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044002712	Transposase; Region: HTH_Tnp_1; cl17663
365044002713	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044002714	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
365044002715	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
365044002716	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
365044002717	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
365044002718	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002720	active site
365044002721	phosphorylation site [posttranslational modification]
365044002722	intermolecular recognition site; other site
365044002723	dimerization interface [polypeptide binding]; other site
365044002724	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
365044002725	cyclase homology domain; Region: CHD; cd07302
365044002726	nucleotidyl binding site; other site
365044002727	metal binding site [ion binding]; metal-binding site
365044002728	dimer interface [polypeptide binding]; other site
365044002729	Cache domain; Region: Cache_1; pfam02743
365044002730	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002731	dimer interface [polypeptide binding]; other site
365044002732	phosphorylation site [posttranslational modification]
365044002733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002734	ATP binding site [chemical binding]; other site
365044002735	Mg2+ binding site [ion binding]; other site
365044002736	G-X-G motif; other site
365044002737	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002739	active site
365044002740	phosphorylation site [posttranslational modification]
365044002741	intermolecular recognition site; other site
365044002742	dimerization interface [polypeptide binding]; other site
365044002743	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002745	active site
365044002746	phosphorylation site [posttranslational modification]
365044002747	intermolecular recognition site; other site
365044002748	dimerization interface [polypeptide binding]; other site
365044002749	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044002750	putative binding surface; other site
365044002751	active site
365044002752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044002753	Coenzyme A binding pocket [chemical binding]; other site
365044002754	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
365044002755	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365044002756	Transporter associated domain; Region: CorC_HlyC; smart01091
365044002757	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
365044002758	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
365044002759	putative active site [active]
365044002760	catalytic triad [active]
365044002761	putative dimer interface [polypeptide binding]; other site
365044002762	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044002763	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044002764	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044002765	dimerization interface [polypeptide binding]; other site
365044002766	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
365044002767	homodimer interface [polypeptide binding]; other site
365044002768	active site
365044002769	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
365044002770	dimer interface [polypeptide binding]; other site
365044002771	motif 1; other site
365044002772	active site
365044002773	motif 2; other site
365044002774	motif 3; other site
365044002775	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
365044002776	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
365044002777	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044002778	active site
365044002779	motif I; other site
365044002780	motif II; other site
365044002781	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
365044002782	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044002783	putative acyl-acceptor binding pocket; other site
365044002784	Protein of unknown function DUF45; Region: DUF45; pfam01863
365044002785	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002787	active site
365044002788	phosphorylation site [posttranslational modification]
365044002789	intermolecular recognition site; other site
365044002790	dimerization interface [polypeptide binding]; other site
365044002791	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044002792	dimerization interface [polypeptide binding]; other site
365044002793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002794	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
365044002795	putative active site [active]
365044002796	heme pocket [chemical binding]; other site
365044002797	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002798	putative active site [active]
365044002799	heme pocket [chemical binding]; other site
365044002800	GAF domain; Region: GAF; pfam01590
365044002801	GAF domain; Region: GAF_2; pfam13185
365044002802	PAS domain S-box; Region: sensory_box; TIGR00229
365044002803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002804	putative active site [active]
365044002805	heme pocket [chemical binding]; other site
365044002806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002807	dimer interface [polypeptide binding]; other site
365044002808	phosphorylation site [posttranslational modification]
365044002809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002810	ATP binding site [chemical binding]; other site
365044002811	Mg2+ binding site [ion binding]; other site
365044002812	G-X-G motif; other site
365044002813	Helix-turn-helix domain; Region: HTH_17; pfam12728
365044002814	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002816	active site
365044002817	phosphorylation site [posttranslational modification]
365044002818	intermolecular recognition site; other site
365044002819	dimerization interface [polypeptide binding]; other site
365044002820	PAS domain; Region: PAS; smart00091
365044002821	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
365044002822	putative active site [active]
365044002823	heme pocket [chemical binding]; other site
365044002824	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044002825	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002826	putative active site [active]
365044002827	heme pocket [chemical binding]; other site
365044002828	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
365044002829	dimer interface [polypeptide binding]; other site
365044002830	phosphorylation site [posttranslational modification]
365044002831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002832	ATP binding site [chemical binding]; other site
365044002833	Mg2+ binding site [ion binding]; other site
365044002834	G-X-G motif; other site
365044002835	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
365044002836	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
365044002837	DNA binding residues [nucleotide binding]
365044002838	putative dimer interface [polypeptide binding]; other site
365044002839	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044002840	CoenzymeA binding site [chemical binding]; other site
365044002841	subunit interaction site [polypeptide binding]; other site
365044002842	PHB binding site; other site
365044002843	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
365044002844	isovaleryl-CoA dehydrogenase; Region: PLN02519
365044002845	substrate binding site [chemical binding]; other site
365044002846	FAD binding site [chemical binding]; other site
365044002847	catalytic base [active]
365044002848	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
365044002849	active site clefts [active]
365044002850	zinc binding site [ion binding]; other site
365044002851	dimer interface [polypeptide binding]; other site
365044002852	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
365044002853	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
365044002854	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
365044002855	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044002856	dimer interface [polypeptide binding]; other site
365044002857	active site
365044002858	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044002859	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044002860	active site
365044002861	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
365044002862	active site
365044002863	catalytic residue [active]
365044002864	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
365044002865	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044002866	catalytic residue [active]
365044002867	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
365044002868	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
365044002869	hypothetical protein; Provisional; Region: PRK01842
365044002870	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
365044002871	Ion channel; Region: Ion_trans_2; pfam07885
365044002872	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
365044002873	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044002874	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044002875	AMP-binding domain protein; Validated; Region: PRK08315
365044002876	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044002877	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
365044002878	acyl-activating enzyme (AAE) consensus motif; other site
365044002879	acyl-activating enzyme (AAE) consensus motif; other site
365044002880	putative AMP binding site [chemical binding]; other site
365044002881	putative active site [active]
365044002882	putative CoA binding site [chemical binding]; other site
365044002883	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
365044002884	DinB family; Region: DinB; cl17821
365044002885	DinB superfamily; Region: DinB_2; pfam12867
365044002886	enoyl-CoA hydratase; Provisional; Region: PRK05995
365044002887	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044002888	substrate binding site [chemical binding]; other site
365044002889	oxyanion hole (OAH) forming residues; other site
365044002890	trimer interface [polypeptide binding]; other site
365044002891	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
365044002892	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
365044002893	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044002894	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365044002895	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
365044002896	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044002897	carboxyltransferase (CT) interaction site; other site
365044002898	biotinylation site [posttranslational modification]; other site
365044002899	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
365044002900	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
365044002901	putative ligand binding site [chemical binding]; other site
365044002902	NAD binding site [chemical binding]; other site
365044002903	dimerization interface [polypeptide binding]; other site
365044002904	catalytic site [active]
365044002905	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
365044002906	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044002907	active site
365044002908	catalytic residues [active]
365044002909	metal binding site [ion binding]; metal-binding site
365044002910	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
365044002911	putative deacylase active site [active]
365044002912	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
365044002913	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
365044002914	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
365044002915	putative catalytic residue [active]
365044002916	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
365044002917	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044002918	ligand binding site [chemical binding]; other site
365044002919	flexible hinge region; other site
365044002920	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
365044002921	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044002922	metal binding triad; other site
365044002923	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
365044002924	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365044002925	active site
365044002926	catalytic site [active]
365044002927	substrate binding site [chemical binding]; other site
365044002928	BON domain; Region: BON; pfam04972
365044002929	Protein of unknown function, DUF485; Region: DUF485; pfam04341
365044002930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044002931	putative substrate translocation pore; other site
365044002932	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044002933	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044002934	putative ligand binding site [chemical binding]; other site
365044002935	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
365044002936	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365044002937	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365044002938	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044002939	Walker A/P-loop; other site
365044002940	ATP binding site [chemical binding]; other site
365044002941	Q-loop/lid; other site
365044002942	ABC transporter signature motif; other site
365044002943	Walker B; other site
365044002944	D-loop; other site
365044002945	H-loop/switch region; other site
365044002946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044002947	Walker A/P-loop; other site
365044002948	ATP binding site [chemical binding]; other site
365044002949	Q-loop/lid; other site
365044002950	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
365044002951	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365044002952	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
365044002953	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
365044002954	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
365044002955	homotetramer interface [polypeptide binding]; other site
365044002956	ligand binding site [chemical binding]; other site
365044002957	catalytic site [active]
365044002958	NAD binding site [chemical binding]; other site
365044002959	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044002960	RNA binding surface [nucleotide binding]; other site
365044002961	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
365044002962	FtsJ-like methyltransferase; Region: FtsJ; cl17430
365044002963	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
365044002964	FAD binding site [chemical binding]; other site
365044002965	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
365044002966	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
365044002967	Predicted transcriptional regulators [Transcription]; Region: COG1510
365044002968	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044002969	dimerization interface [polypeptide binding]; other site
365044002970	putative DNA binding site [nucleotide binding]; other site
365044002971	putative Zn2+ binding site [ion binding]; other site
365044002972	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
365044002973	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
365044002974	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
365044002975	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
365044002976	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
365044002977	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
365044002978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002979	Walker A motif; other site
365044002980	ATP binding site [chemical binding]; other site
365044002981	Walker B motif; other site
365044002982	arginine finger; other site
365044002983	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
365044002984	hypothetical protein; Reviewed; Region: PRK09588
365044002985	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
365044002986	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
365044002987	putative active site [active]
365044002988	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
365044002989	23S rRNA interface [nucleotide binding]; other site
365044002990	L3 interface [polypeptide binding]; other site
365044002991	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
365044002992	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
365044002993	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
365044002994	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
365044002995	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
365044002996	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
365044002997	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
365044002998	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044002999	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
365044003000	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
365044003001	active site
365044003002	HIGH motif; other site
365044003003	dimer interface [polypeptide binding]; other site
365044003004	KMSKS motif; other site
365044003005	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
365044003006	putative active site [active]
365044003007	dimerization interface [polypeptide binding]; other site
365044003008	putative tRNAtyr binding site [nucleotide binding]; other site
365044003009	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
365044003010	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
365044003011	PhoH-like protein; Region: PhoH; pfam02562
365044003012	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
365044003013	RuvA N terminal domain; Region: RuvA_N; pfam01330
365044003014	Protein of unknown function (DUF511); Region: DUF511; pfam04373
365044003015	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
365044003016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003017	Walker A motif; other site
365044003018	ATP binding site [chemical binding]; other site
365044003019	Walker B motif; other site
365044003020	arginine finger; other site
365044003021	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
365044003022	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
365044003023	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
365044003024	dimer interface [polypeptide binding]; other site
365044003025	active site
365044003026	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044003027	substrate binding site [chemical binding]; other site
365044003028	catalytic residue [active]
365044003029	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044003030	catalytic core [active]
365044003031	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
365044003032	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
365044003033	Ligand Binding Site [chemical binding]; other site
365044003034	Dihydroneopterin aldolase; Region: FolB; smart00905
365044003035	active site
365044003036	short chain dehydrogenase; Provisional; Region: PRK09134
365044003037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044003038	NAD(P) binding site [chemical binding]; other site
365044003039	active site
365044003040	Uncharacterized conserved protein [Function unknown]; Region: COG1565
365044003041	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
365044003042	HipA N-terminal domain; Region: Couple_hipA; pfam13657
365044003043	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044003044	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044003045	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
365044003046	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
365044003047	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
365044003048	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
365044003049	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
365044003050	active site
365044003051	homotetramer interface [polypeptide binding]; other site
365044003052	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
365044003053	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
365044003054	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
365044003055	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
365044003056	lytic murein transglycosylase; Provisional; Region: PRK11619
365044003057	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044003058	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044003059	catalytic residue [active]
365044003060	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
365044003061	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
365044003062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044003063	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
365044003064	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
365044003065	dimerization interface [polypeptide binding]; other site
365044003066	substrate binding pocket [chemical binding]; other site
365044003067	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
365044003068	Sensors of blue-light using FAD; Region: BLUF; smart01034
365044003069	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044003070	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044003071	ligand binding site [chemical binding]; other site
365044003072	flexible hinge region; other site
365044003073	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044003074	putative switch regulator; other site
365044003075	non-specific DNA interactions [nucleotide binding]; other site
365044003076	DNA binding site [nucleotide binding]
365044003077	sequence specific DNA binding site [nucleotide binding]; other site
365044003078	putative cAMP binding site [chemical binding]; other site
365044003079	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
365044003080	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
365044003081	Substrate binding site; other site
365044003082	Mg++ binding site; other site
365044003083	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
365044003084	active site
365044003085	substrate binding site [chemical binding]; other site
365044003086	CoA binding site [chemical binding]; other site
365044003087	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044003088	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044003089	putative DNA binding site [nucleotide binding]; other site
365044003090	putative Zn2+ binding site [ion binding]; other site
365044003091	AsnC family; Region: AsnC_trans_reg; pfam01037
365044003092	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
365044003093	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
365044003094	glutaminase active site [active]
365044003095	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
365044003096	dimer interface [polypeptide binding]; other site
365044003097	active site
365044003098	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
365044003099	dimer interface [polypeptide binding]; other site
365044003100	active site
365044003101	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044003102	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044003103	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
365044003104	active site residue [active]
365044003105	serine O-acetyltransferase; Region: cysE; TIGR01172
365044003106	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365044003107	trimer interface [polypeptide binding]; other site
365044003108	active site
365044003109	substrate binding site [chemical binding]; other site
365044003110	CoA binding site [chemical binding]; other site
365044003111	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044003112	non-specific DNA binding site [nucleotide binding]; other site
365044003113	salt bridge; other site
365044003114	sequence-specific DNA binding site [nucleotide binding]; other site
365044003115	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
365044003116	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
365044003117	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
365044003118	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044003119	catalytic residue [active]
365044003120	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044003121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044003122	substrate binding pocket [chemical binding]; other site
365044003123	membrane-bound complex binding site; other site
365044003124	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044003125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044003126	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044003127	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
365044003128	Walker A/P-loop; other site
365044003129	ATP binding site [chemical binding]; other site
365044003130	Q-loop/lid; other site
365044003131	ABC transporter signature motif; other site
365044003132	Walker B; other site
365044003133	D-loop; other site
365044003134	H-loop/switch region; other site
365044003135	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
365044003136	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
365044003137	active site
365044003138	dimer interface [polypeptide binding]; other site
365044003139	non-prolyl cis peptide bond; other site
365044003140	insertion regions; other site
365044003141	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044003142	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044003143	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044003144	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044003145	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044003146	Walker A/P-loop; other site
365044003147	ATP binding site [chemical binding]; other site
365044003148	Q-loop/lid; other site
365044003149	ABC transporter signature motif; other site
365044003150	Walker B; other site
365044003151	D-loop; other site
365044003152	H-loop/switch region; other site
365044003153	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044003154	TM-ABC transporter signature motif; other site
365044003155	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044003156	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044003157	TM-ABC transporter signature motif; other site
365044003158	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
365044003159	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044003160	putative ligand binding site [chemical binding]; other site
365044003161	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
365044003162	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
365044003163	Flavin binding site [chemical binding]; other site
365044003164	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
365044003165	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044003166	active site
365044003167	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044003168	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044003169	Walker A/P-loop; other site
365044003170	ATP binding site [chemical binding]; other site
365044003171	Q-loop/lid; other site
365044003172	ABC transporter signature motif; other site
365044003173	Walker B; other site
365044003174	D-loop; other site
365044003175	H-loop/switch region; other site
365044003176	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044003177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003178	Walker A motif; other site
365044003179	ATP binding site [chemical binding]; other site
365044003180	Walker B motif; other site
365044003181	arginine finger; other site
365044003182	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
365044003183	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
365044003184	Flavin binding site [chemical binding]; other site
365044003185	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044003186	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
365044003187	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
365044003188	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
365044003189	active site
365044003190	dimer interface [polypeptide binding]; other site
365044003191	non-prolyl cis peptide bond; other site
365044003192	insertion regions; other site
365044003193	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044003194	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
365044003195	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365044003196	dimer interface [polypeptide binding]; other site
365044003197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044003198	catalytic residue [active]
365044003199	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044003200	substrate binding pocket [chemical binding]; other site
365044003201	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044003202	membrane-bound complex binding site; other site
365044003203	hinge residues; other site
365044003204	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044003205	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003206	Walker A motif; other site
365044003207	ATP binding site [chemical binding]; other site
365044003208	Walker B motif; other site
365044003209	arginine finger; other site
365044003210	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
365044003211	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
365044003212	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365044003213	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
365044003214	DsbD alpha interface [polypeptide binding]; other site
365044003215	catalytic residues [active]
365044003216	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044003217	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044003218	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044003219	E3 interaction surface; other site
365044003220	lipoyl attachment site [posttranslational modification]; other site
365044003221	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044003222	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044003223	Cytochrome C' Region: Cytochrom_C_2; pfam01322
365044003224	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
365044003225	Strictosidine synthase; Region: Str_synth; pfam03088
365044003226	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
365044003227	catalytic triad [active]
365044003228	Cytochrome c553 [Energy production and conversion]; Region: COG2863
365044003229	Cytochrome c; Region: Cytochrom_C; cl11414
365044003230	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
365044003231	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
365044003232	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
365044003233	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
365044003234	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
365044003235	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
365044003236	substrate binding pocket [chemical binding]; other site
365044003237	membrane-bound complex binding site; other site
365044003238	hinge residues; other site
365044003239	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044003240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044003241	ABC-ATPase subunit interface; other site
365044003242	putative PBP binding loops; other site
365044003243	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044003244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044003245	dimer interface [polypeptide binding]; other site
365044003246	putative PBP binding loops; other site
365044003247	ABC-ATPase subunit interface; other site
365044003248	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044003249	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
365044003250	Walker A/P-loop; other site
365044003251	ATP binding site [chemical binding]; other site
365044003252	Q-loop/lid; other site
365044003253	ABC transporter signature motif; other site
365044003254	Walker B; other site
365044003255	D-loop; other site
365044003256	H-loop/switch region; other site
365044003257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044003258	TPR motif; other site
365044003259	binding surface
365044003260	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
365044003261	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
365044003262	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
365044003263	catalytic residues [active]
365044003264	central insert; other site
365044003265	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
365044003266	CcmE; Region: CcmE; pfam03100
365044003267	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
365044003268	CcmB protein; Region: CcmB; pfam03379
365044003269	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
365044003270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044003271	Walker A/P-loop; other site
365044003272	ATP binding site [chemical binding]; other site
365044003273	Q-loop/lid; other site
365044003274	ABC transporter signature motif; other site
365044003275	Walker B; other site
365044003276	D-loop; other site
365044003277	H-loop/switch region; other site
365044003278	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044003279	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044003280	active site residue [active]
365044003281	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044003282	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044003283	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
365044003284	Phage Tail Collar Domain; Region: Collar; pfam07484
365044003285	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
365044003286	FAD binding domain; Region: FAD_binding_4; pfam01565
365044003287	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
365044003288	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044003289	hypothetical protein; Validated; Region: PRK06201
365044003290	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
365044003291	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
365044003292	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044003293	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044003294	DNA-binding site [nucleotide binding]; DNA binding site
365044003295	FCD domain; Region: FCD; pfam07729
365044003296	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044003297	MarR family; Region: MarR_2; pfam12802
365044003298	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044003299	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044003300	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044003301	substrate binding site [chemical binding]; other site
365044003302	oxyanion hole (OAH) forming residues; other site
365044003303	trimer interface [polypeptide binding]; other site
365044003304	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
365044003305	active site
365044003306	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
365044003307	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
365044003308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044003309	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044003310	putative substrate translocation pore; other site
365044003311	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044003312	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
365044003313	NAD(P) binding site [chemical binding]; other site
365044003314	catalytic residues [active]
365044003315	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
365044003316	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
365044003317	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044003318	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
365044003319	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044003320	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044003321	Probable transposase; Region: OrfB_IS605; pfam01385
365044003322	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044003323	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044003324	active site
365044003325	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044003326	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
365044003327	active site
365044003328	metal binding site [ion binding]; metal-binding site
365044003329	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044003330	HTH domain; Region: HTH_11; pfam08279
365044003331	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044003332	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
365044003333	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
365044003334	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044003335	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044003336	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044003337	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
365044003338	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044003339	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044003340	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003341	Walker A motif; other site
365044003342	ATP binding site [chemical binding]; other site
365044003343	Walker B motif; other site
365044003344	arginine finger; other site
365044003345	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044003346	Predicted transcriptional regulators [Transcription]; Region: COG1733
365044003347	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
365044003348	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
365044003349	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
365044003350	NADP binding site [chemical binding]; other site
365044003351	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
365044003352	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044003353	active site
365044003354	substrate binding site [chemical binding]; other site
365044003355	Endonuclease I; Region: Endonuclease_1; pfam04231
365044003356	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044003357	putative active site [active]
365044003358	Putative phage integrase; Region: Phage_Integr_2; pfam13009
365044003359	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044003360	DNA binding site [nucleotide binding]
365044003361	active site
365044003362	Int/Topo IB signature motif; other site
365044003363	catalytic residues [active]
365044003364	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044003365	DNA binding site [nucleotide binding]
365044003366	active site
365044003367	Int/Topo IB signature motif; other site
365044003368	catalytic residues [active]
365044003369	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044003370	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044003371	active site
365044003372	Mg2+ binding site [ion binding]; other site
365044003373	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
365044003374	putative cation:proton antiport protein; Provisional; Region: PRK10669
365044003375	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
365044003376	TrkA-N domain; Region: TrkA_N; pfam02254
365044003377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
365044003378	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
365044003379	AAA domain; Region: AAA_33; pfam13671
365044003380	ATP-binding site [chemical binding]; other site
365044003381	Gluconate-6-phosphate binding site [chemical binding]; other site
365044003382	Predicted membrane protein [Function unknown]; Region: COG2261
365044003383	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
365044003384	Ligand Binding Site [chemical binding]; other site
365044003385	Transmembrane secretion effector; Region: MFS_3; pfam05977
365044003386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044003387	putative substrate translocation pore; other site
365044003388	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
365044003389	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
365044003390	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
365044003391	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
365044003392	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
365044003393	catalytic core [active]
365044003394	cobalamin synthase; Reviewed; Region: cobS; PRK00235
365044003395	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
365044003396	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
365044003397	putative dimer interface [polypeptide binding]; other site
365044003398	active site pocket [active]
365044003399	putative cataytic base [active]
365044003400	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
365044003401	threonine dehydratase; Reviewed; Region: PRK09224
365044003402	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
365044003403	tetramer interface [polypeptide binding]; other site
365044003404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044003405	catalytic residue [active]
365044003406	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
365044003407	putative Ile/Val binding site [chemical binding]; other site
365044003408	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
365044003409	putative Ile/Val binding site [chemical binding]; other site
365044003410	OsmC-like protein; Region: OsmC; cl00767
365044003411	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
365044003412	diiron binding motif [ion binding]; other site
365044003413	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044003414	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003415	trimer interface [polypeptide binding]; other site
365044003416	eyelet of channel; other site
365044003417	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044003418	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003419	eyelet of channel; other site
365044003420	trimer interface [polypeptide binding]; other site
365044003421	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044003422	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003423	trimer interface [polypeptide binding]; other site
365044003424	eyelet of channel; other site
365044003425	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
365044003426	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
365044003427	metal binding site [ion binding]; metal-binding site
365044003428	putative dimer interface [polypeptide binding]; other site
365044003429	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
365044003430	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
365044003431	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
365044003432	putative active site [active]
365044003433	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
365044003434	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
365044003435	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
365044003436	transaldolase-like protein; Provisional; Region: PTZ00411
365044003437	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
365044003438	active site
365044003439	dimer interface [polypeptide binding]; other site
365044003440	catalytic residue [active]
365044003441	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
365044003442	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
365044003443	active site
365044003444	dimer interface [polypeptide binding]; other site
365044003445	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
365044003446	dimer interface [polypeptide binding]; other site
365044003447	active site
365044003448	Protein of unknown function (DUF805); Region: DUF805; pfam05656
365044003449	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
365044003450	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
365044003451	ring oligomerisation interface [polypeptide binding]; other site
365044003452	ATP/Mg binding site [chemical binding]; other site
365044003453	stacking interactions; other site
365044003454	hinge regions; other site
365044003455	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
365044003456	oligomerisation interface [polypeptide binding]; other site
365044003457	mobile loop; other site
365044003458	roof hairpin; other site
365044003459	S-adenosylmethionine synthetase; Validated; Region: PRK05250
365044003460	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
365044003461	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
365044003462	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
365044003463	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
365044003464	putative acyl-acceptor binding pocket; other site
365044003465	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
365044003466	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
365044003467	putative acyl-acceptor binding pocket; other site
365044003468	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
365044003469	G1 box; other site
365044003470	GTP/Mg2+ binding site [chemical binding]; other site
365044003471	Switch I region; other site
365044003472	G2 box; other site
365044003473	G3 box; other site
365044003474	Switch II region; other site
365044003475	G4 box; other site
365044003476	G5 box; other site
365044003477	Cytochrome c553 [Energy production and conversion]; Region: COG2863
365044003478	Cytochrome c; Region: Cytochrom_C; cl11414
365044003479	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
365044003480	ResB-like family; Region: ResB; pfam05140
365044003481	ResB-like family; Region: ResB; pfam05140
365044003482	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
365044003483	TMAO/DMSO reductase; Reviewed; Region: PRK05363
365044003484	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
365044003485	Moco binding site; other site
365044003486	metal coordination site [ion binding]; other site
365044003487	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
365044003488	diaminopimelate decarboxylase; Region: lysA; TIGR01048
365044003489	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
365044003490	active site
365044003491	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044003492	substrate binding site [chemical binding]; other site
365044003493	catalytic residues [active]
365044003494	dimer interface [polypeptide binding]; other site
365044003495	Frataxin-like domain; Region: Frataxin_Cyay; pfam01491
365044003496	putative iron binding site [ion binding]; other site
365044003497	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
365044003498	Transglycosylase; Region: Transgly; pfam00912
365044003499	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
365044003500	Competence protein A; Region: Competence_A; pfam11104
365044003501	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
365044003502	nucleotide binding site [chemical binding]; other site
365044003503	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
365044003504	Pilus assembly protein, PilO; Region: PilO; pfam04350
365044003505	Pilus assembly protein, PilP; Region: PilP; pfam04351
365044003506	AMIN domain; Region: AMIN; pfam11741
365044003507	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
365044003508	Secretin and TonB N terminus short domain; Region: STN; smart00965
365044003509	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003510	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
365044003511	shikimate kinase; Reviewed; Region: aroK; PRK00131
365044003512	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
365044003513	ADP binding site [chemical binding]; other site
365044003514	magnesium binding site [ion binding]; other site
365044003515	putative shikimate binding site; other site
365044003516	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
365044003517	active site
365044003518	dimer interface [polypeptide binding]; other site
365044003519	metal binding site [ion binding]; metal-binding site
365044003520	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
365044003521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365044003522	Zn2+ binding site [ion binding]; other site
365044003523	Mg2+ binding site [ion binding]; other site
365044003524	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
365044003525	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044003526	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044003527	putative ligand binding site [chemical binding]; other site
365044003528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
365044003529	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
365044003530	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
365044003531	active site
365044003532	dimer interface [polypeptide binding]; other site
365044003533	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
365044003534	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
365044003535	active site
365044003536	FMN binding site [chemical binding]; other site
365044003537	substrate binding site [chemical binding]; other site
365044003538	3Fe-4S cluster binding site [ion binding]; other site
365044003539	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
365044003540	domain interface; other site
365044003541	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
365044003542	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044003543	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
365044003544	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
365044003545	Walker A/P-loop; other site
365044003546	ATP binding site [chemical binding]; other site
365044003547	Q-loop/lid; other site
365044003548	ABC transporter signature motif; other site
365044003549	Walker B; other site
365044003550	D-loop; other site
365044003551	H-loop/switch region; other site
365044003552	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
365044003553	Permease; Region: Permease; pfam02405
365044003554	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
365044003555	mce related protein; Region: MCE; pfam02470
365044003556	VacJ like lipoprotein; Region: VacJ; cl01073
365044003557	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
365044003558	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
365044003559	anti sigma factor interaction site; other site
365044003560	regulatory phosphorylation site [posttranslational modification]; other site
365044003561	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
365044003562	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
365044003563	Walker A/P-loop; other site
365044003564	ATP binding site [chemical binding]; other site
365044003565	Q-loop/lid; other site
365044003566	ABC transporter signature motif; other site
365044003567	Walker B; other site
365044003568	D-loop; other site
365044003569	H-loop/switch region; other site
365044003570	ABC-2 type transporter; Region: ABC2_membrane; cl17235
365044003571	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
365044003572	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
365044003573	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
365044003574	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
365044003575	hinge; other site
365044003576	active site
365044003577	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
365044003578	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
365044003579	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
365044003580	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
365044003581	NAD binding site [chemical binding]; other site
365044003582	dimerization interface [polypeptide binding]; other site
365044003583	product binding site; other site
365044003584	substrate binding site [chemical binding]; other site
365044003585	zinc binding site [ion binding]; other site
365044003586	catalytic residues [active]
365044003587	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
365044003588	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044003589	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044003590	homodimer interface [polypeptide binding]; other site
365044003591	catalytic residue [active]
365044003592	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
365044003593	putative active site pocket [active]
365044003594	4-fold oligomerization interface [polypeptide binding]; other site
365044003595	metal binding residues [ion binding]; metal-binding site
365044003596	3-fold/trimer interface [polypeptide binding]; other site
365044003597	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
365044003598	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
365044003599	putative active site [active]
365044003600	oxyanion strand; other site
365044003601	catalytic triad [active]
365044003602	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
365044003603	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
365044003604	catalytic residues [active]
365044003605	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
365044003606	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
365044003607	substrate binding site [chemical binding]; other site
365044003608	glutamase interaction surface [polypeptide binding]; other site
365044003609	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
365044003610	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
365044003611	metal binding site [ion binding]; metal-binding site
365044003612	Predicted membrane protein [Function unknown]; Region: COG3671
365044003613	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
365044003614	nucleotide binding site/active site [active]
365044003615	HIT family signature motif; other site
365044003616	catalytic residue [active]
365044003617	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
365044003618	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
365044003619	sec-independent translocase; Provisional; Region: tatB; PRK01919
365044003620	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
365044003621	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
365044003622	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044003623	protein binding site [polypeptide binding]; other site
365044003624	Uncharacterized conserved protein [Function unknown]; Region: COG0327
365044003625	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
365044003626	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
365044003627	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
365044003628	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
365044003629	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
365044003630	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
365044003631	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
365044003632	[2Fe-2S] cluster binding site [ion binding]; other site
365044003633	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
365044003634	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
365044003635	Qi binding site; other site
365044003636	intrachain domain interface; other site
365044003637	interchain domain interface [polypeptide binding]; other site
365044003638	heme bH binding site [chemical binding]; other site
365044003639	heme bL binding site [chemical binding]; other site
365044003640	Qo binding site; other site
365044003641	interchain domain interface [polypeptide binding]; other site
365044003642	intrachain domain interface; other site
365044003643	Qi binding site; other site
365044003644	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
365044003645	Qo binding site; other site
365044003646	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
365044003647	stringent starvation protein A; Provisional; Region: sspA; PRK09481
365044003648	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
365044003649	C-terminal domain interface [polypeptide binding]; other site
365044003650	putative GSH binding site (G-site) [chemical binding]; other site
365044003651	dimer interface [polypeptide binding]; other site
365044003652	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
365044003653	dimer interface [polypeptide binding]; other site
365044003654	N-terminal domain interface [polypeptide binding]; other site
365044003655	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
365044003656	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
365044003657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044003658	Walker A/P-loop; other site
365044003659	ATP binding site [chemical binding]; other site
365044003660	Q-loop/lid; other site
365044003661	ABC transporter signature motif; other site
365044003662	Walker B; other site
365044003663	D-loop; other site
365044003664	H-loop/switch region; other site
365044003665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003666	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044003667	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003668	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003669	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003670	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003671	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
365044003672	ligand binding site [chemical binding]; other site
365044003673	ABC-2 type transporter; Region: ABC2_membrane; cl17235
365044003674	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
365044003675	Predicted secreted protein [Function unknown]; Region: COG5501
365044003676	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
365044003677	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
365044003678	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365044003679	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
365044003680	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
365044003681	dimer interface [polypeptide binding]; other site
365044003682	Trp docking motif [polypeptide binding]; other site
365044003683	active site
365044003684	Cytochrome c; Region: Cytochrom_C; cl11414
365044003685	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
365044003686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044003687	FeS/SAM binding site; other site
365044003688	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
365044003689	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
365044003690	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
365044003691	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
365044003692	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
365044003693	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
365044003694	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365044003695	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044003696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003697	Walker A motif; other site
365044003698	ATP binding site [chemical binding]; other site
365044003699	Walker B motif; other site
365044003700	arginine finger; other site
365044003701	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044003702	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
365044003703	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044003704	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044003705	substrate binding pocket [chemical binding]; other site
365044003706	membrane-bound complex binding site; other site
365044003707	hinge residues; other site
365044003708	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
365044003709	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
365044003710	SEC-C motif; Region: SEC-C; pfam02810
365044003711	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
365044003712	heterotetramer interface [polypeptide binding]; other site
365044003713	active site pocket [active]
365044003714	cleavage site
365044003715	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
365044003716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003717	Walker A motif; other site
365044003718	ATP binding site [chemical binding]; other site
365044003719	Walker B motif; other site
365044003720	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
365044003721	active site
365044003722	8-oxo-dGMP binding site [chemical binding]; other site
365044003723	nudix motif; other site
365044003724	metal binding site [ion binding]; metal-binding site
365044003725	patatin-related protein; Region: TIGR03607
365044003726	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
365044003727	Domain of unknown function DUF21; Region: DUF21; pfam01595
365044003728	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365044003729	Transporter associated domain; Region: CorC_HlyC; smart01091
365044003730	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
365044003731	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044003732	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044003733	catalytic residue [active]
365044003734	prolyl-tRNA synthetase; Provisional; Region: PRK09194
365044003735	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
365044003736	dimer interface [polypeptide binding]; other site
365044003737	motif 1; other site
365044003738	active site
365044003739	motif 2; other site
365044003740	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
365044003741	putative deacylase active site [active]
365044003742	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
365044003743	active site
365044003744	motif 3; other site
365044003745	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
365044003746	anticodon binding site; other site
365044003747	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
365044003748	putative active site [active]
365044003749	Ap4A binding site [chemical binding]; other site
365044003750	nudix motif; other site
365044003751	putative metal binding site [ion binding]; other site
365044003752	CNP1-like family; Region: CNP1; pfam08750
365044003753	gamma-glutamyl kinase; Provisional; Region: PRK05429
365044003754	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
365044003755	nucleotide binding site [chemical binding]; other site
365044003756	homotetrameric interface [polypeptide binding]; other site
365044003757	putative phosphate binding site [ion binding]; other site
365044003758	putative allosteric binding site; other site
365044003759	PUA domain; Region: PUA; pfam01472
365044003760	GTPase CgtA; Reviewed; Region: obgE; PRK12299
365044003761	GTP1/OBG; Region: GTP1_OBG; pfam01018
365044003762	Obg GTPase; Region: Obg; cd01898
365044003763	G1 box; other site
365044003764	GTP/Mg2+ binding site [chemical binding]; other site
365044003765	Switch I region; other site
365044003766	G2 box; other site
365044003767	G3 box; other site
365044003768	Switch II region; other site
365044003769	G4 box; other site
365044003770	G5 box; other site
365044003771	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
365044003772	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
365044003773	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
365044003774	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
365044003775	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
365044003776	substrate binding pocket [chemical binding]; other site
365044003777	chain length determination region; other site
365044003778	substrate-Mg2+ binding site; other site
365044003779	catalytic residues [active]
365044003780	aspartate-rich region 1; other site
365044003781	active site lid residues [active]
365044003782	aspartate-rich region 2; other site
365044003783	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
365044003784	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
365044003785	type II secretion system protein F; Region: GspF; TIGR02120
365044003786	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
365044003787	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
365044003788	type II secretion system protein E; Region: type_II_gspE; TIGR02533
365044003789	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
365044003790	Walker A motif; other site
365044003791	ATP binding site [chemical binding]; other site
365044003792	Walker B motif; other site
365044003793	type II secretion system protein D; Region: type_II_gspD; TIGR02517
365044003794	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003795	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003796	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003797	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
365044003798	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
365044003799	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
365044003800	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
365044003801	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
365044003802	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
365044003803	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
365044003804	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
365044003805	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044003806	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
365044003807	Walker A motif; other site
365044003808	ATP binding site [chemical binding]; other site
365044003809	Walker B motif; other site
365044003810	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
365044003811	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
365044003812	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
365044003813	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
365044003814	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
365044003815	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
365044003816	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
365044003817	dephospho-CoA kinase; Region: TIGR00152
365044003818	CoA-binding site [chemical binding]; other site
365044003819	ATP-binding [chemical binding]; other site
365044003820	hypothetical protein; Provisional; Region: PRK05287
365044003821	Domain of unknown function (DUF329); Region: DUF329; pfam03884
365044003822	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
365044003823	putative GSH binding site [chemical binding]; other site
365044003824	catalytic residues [active]
365044003825	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
365044003826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044003827	S-adenosylmethionine binding site [chemical binding]; other site
365044003828	peptide chain release factor 1; Validated; Region: prfA; PRK00591
365044003829	This domain is found in peptide chain release factors; Region: PCRF; smart00937
365044003830	RF-1 domain; Region: RF-1; pfam00472
365044003831	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
365044003832	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
365044003833	tRNA; other site
365044003834	putative tRNA binding site [nucleotide binding]; other site
365044003835	putative NADP binding site [chemical binding]; other site
365044003836	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
365044003837	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
365044003838	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044003839	FAD binding domain; Region: FAD_binding_4; pfam01565
365044003840	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044003841	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
365044003842	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
365044003843	Cysteine-rich domain; Region: CCG; pfam02754
365044003844	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
365044003845	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
365044003846	HIT family signature motif; other site
365044003847	catalytic residue [active]
365044003848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
365044003849	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
365044003850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044003851	S-adenosylmethionine binding site [chemical binding]; other site
365044003852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
365044003853	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
365044003854	SCP-2 sterol transfer family; Region: SCP2; pfam02036
365044003855	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
365044003856	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
365044003857	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
365044003858	Uncharacterized conserved protein [Function unknown]; Region: COG2928
365044003859	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
365044003860	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
365044003861	dimer interface [polypeptide binding]; other site
365044003862	anticodon binding site; other site
365044003863	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
365044003864	homodimer interface [polypeptide binding]; other site
365044003865	motif 1; other site
365044003866	active site
365044003867	motif 2; other site
365044003868	GAD domain; Region: GAD; pfam02938
365044003869	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
365044003870	motif 3; other site
365044003871	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044003872	Ligand Binding Site [chemical binding]; other site
365044003873	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365044003874	Histidine kinase; Region: HisKA_3; pfam07730
365044003875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044003876	ATP binding site [chemical binding]; other site
365044003877	Mg2+ binding site [ion binding]; other site
365044003878	G-X-G motif; other site
365044003879	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044003880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044003881	active site
365044003882	phosphorylation site [posttranslational modification]
365044003883	intermolecular recognition site; other site
365044003884	dimerization interface [polypeptide binding]; other site
365044003885	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044003886	DNA binding residues [nucleotide binding]
365044003887	dimerization interface [polypeptide binding]; other site
365044003888	Response regulator receiver domain; Region: Response_reg; pfam00072
365044003889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044003890	active site
365044003891	phosphorylation site [posttranslational modification]
365044003892	intermolecular recognition site; other site
365044003893	dimerization interface [polypeptide binding]; other site
365044003894	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
365044003895	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044003896	ligand binding site [chemical binding]; other site
365044003897	flexible hinge region; other site
365044003898	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044003899	putative switch regulator; other site
365044003900	non-specific DNA interactions [nucleotide binding]; other site
365044003901	DNA binding site [nucleotide binding]
365044003902	sequence specific DNA binding site [nucleotide binding]; other site
365044003903	putative cAMP binding site [chemical binding]; other site
365044003904	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
365044003905	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044003906	feruloyl-CoA synthase; Reviewed; Region: PRK08180
365044003907	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
365044003908	acyl-activating enzyme (AAE) consensus motif; other site
365044003909	putative AMP binding site [chemical binding]; other site
365044003910	putative active site [active]
365044003911	putative CoA binding site [chemical binding]; other site
365044003912	putative acyltransferase; Provisional; Region: PRK05790
365044003913	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044003914	dimer interface [polypeptide binding]; other site
365044003915	active site
365044003916	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
365044003917	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
365044003918	NAD binding site [chemical binding]; other site
365044003919	homodimer interface [polypeptide binding]; other site
365044003920	homotetramer interface [polypeptide binding]; other site
365044003921	active site
365044003922	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044003923	active site
365044003924	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044003925	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
365044003926	putative ligand binding site [chemical binding]; other site
365044003927	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
365044003928	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044003929	TM-ABC transporter signature motif; other site
365044003930	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044003931	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044003932	TM-ABC transporter signature motif; other site
365044003933	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044003934	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044003935	Walker A/P-loop; other site
365044003936	ATP binding site [chemical binding]; other site
365044003937	Q-loop/lid; other site
365044003938	ABC transporter signature motif; other site
365044003939	Walker B; other site
365044003940	D-loop; other site
365044003941	H-loop/switch region; other site
365044003942	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044003943	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044003944	Walker A/P-loop; other site
365044003945	ATP binding site [chemical binding]; other site
365044003946	Q-loop/lid; other site
365044003947	ABC transporter signature motif; other site
365044003948	Walker B; other site
365044003949	D-loop; other site
365044003950	H-loop/switch region; other site
365044003951	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044003952	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003953	trimer interface [polypeptide binding]; other site
365044003954	eyelet of channel; other site
365044003955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003956	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044003957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044003958	active site
365044003959	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044003960	MarR family; Region: MarR_2; pfam12802
365044003961	MarR family; Region: MarR_2; cl17246
365044003962	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
365044003963	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
365044003964	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365044003965	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
365044003966	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365044003967	Zn2+ binding site [ion binding]; other site
365044003968	Mg2+ binding site [ion binding]; other site
365044003969	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
365044003970	synthetase active site [active]
365044003971	NTP binding site [chemical binding]; other site
365044003972	metal binding site [ion binding]; metal-binding site
365044003973	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
365044003974	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
365044003975	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
365044003976	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
365044003977	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
365044003978	catalytic site [active]
365044003979	G-X2-G-X-G-K; other site
365044003980	hypothetical protein; Provisional; Region: PRK11820
365044003981	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
365044003982	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
365044003983	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
365044003984	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044003985	active site
365044003986	ATP binding site [chemical binding]; other site
365044003987	substrate binding site [chemical binding]; other site
365044003988	activation loop (A-loop); other site
365044003989	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044003990	Protein phosphatase 2C; Region: PP2C; pfam00481
365044003991	active site
365044003992	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
365044003993	active site
365044003994	dimerization interface [polypeptide binding]; other site
365044003995	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
365044003996	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044003997	FeS/SAM binding site; other site
365044003998	HemN C-terminal domain; Region: HemN_C; pfam06969
365044003999	ADP-dependent glucokinase; Provisional; Region: PRK14039
365044004000	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
365044004001	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
365044004002	active site
365044004003	HIGH motif; other site
365044004004	KMSKS motif; other site
365044004005	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
365044004006	anticodon binding site; other site
365044004007	tRNA binding surface [nucleotide binding]; other site
365044004008	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
365044004009	dimer interface [polypeptide binding]; other site
365044004010	putative tRNA-binding site [nucleotide binding]; other site
365044004011	Found in ATP-dependent protease La (LON); Region: LON; smart00464
365044004012	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
365044004013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044004014	Walker A motif; other site
365044004015	ATP binding site [chemical binding]; other site
365044004016	Walker B motif; other site
365044004017	arginine finger; other site
365044004018	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
365044004019	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
365044004020	hypothetical protein; Provisional; Region: PRK08609
365044004021	active site
365044004022	primer binding site [nucleotide binding]; other site
365044004023	NTP  binding site [chemical binding]; other site
365044004024	metal binding triad [ion binding]; metal-binding site
365044004025	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
365044004026	active site
365044004027	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
365044004028	30S subunit binding site; other site
365044004029	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
365044004030	DNA-binding site [nucleotide binding]; DNA binding site
365044004031	RNA-binding motif; other site
365044004032	antiporter inner membrane protein; Provisional; Region: PRK11670
365044004033	Domain of unknown function DUF59; Region: DUF59; pfam01883
365044004034	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
365044004035	Walker A motif; other site
365044004036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044004037	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
365044004038	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044004039	dimerization interface [polypeptide binding]; other site
365044004040	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
365044004041	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
365044004042	putative dimer interface [polypeptide binding]; other site
365044004043	[2Fe-2S] cluster binding site [ion binding]; other site
365044004044	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
365044004045	SLBB domain; Region: SLBB; pfam10531
365044004046	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
365044004047	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
365044004048	NlpC/P60 family; Region: NLPC_P60; pfam00877
365044004049	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
365044004050	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
365044004051	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
365044004052	4Fe-4S binding domain; Region: Fer4; pfam00037
365044004053	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044004054	4Fe-4S binding domain; Region: Fer4; pfam00037
365044004055	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044004056	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
365044004057	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
365044004058	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
365044004059	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
365044004060	[4Fe-4S] binding site [ion binding]; other site
365044004061	molybdopterin cofactor binding site; other site
365044004062	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044004063	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
365044004064	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
365044004065	molybdopterin cofactor binding site; other site
365044004066	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
365044004067	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
365044004068	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
365044004069	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
365044004070	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004071	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
365044004072	classical (c) SDRs; Region: SDR_c; cd05233
365044004073	NAD(P) binding site [chemical binding]; other site
365044004074	active site
365044004075	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044004076	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044004077	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004078	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
365044004079	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
365044004080	NAD binding site [chemical binding]; other site
365044004081	Helix-turn-helix domain; Region: HTH_17; pfam12728
365044004082	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
365044004083	dimer interface [polypeptide binding]; other site
365044004084	active site
365044004085	coenzyme A binding site [chemical binding]; other site
365044004086	citrylCoA binding site [chemical binding]; other site
365044004087	Citrate synthase; Region: Citrate_synt; pfam00285
365044004088	oxalacetate/citrate binding site [chemical binding]; other site
365044004089	catalytic triad [active]
365044004090	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
365044004091	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044004092	apolar tunnel; other site
365044004093	heme binding site [chemical binding]; other site
365044004094	dimerization interface [polypeptide binding]; other site
365044004095	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
365044004096	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
365044004097	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
365044004098	MORN repeat; Region: MORN; pfam02493
365044004099	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365044004100	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
365044004101	Walker A/P-loop; other site
365044004102	ATP binding site [chemical binding]; other site
365044004103	Q-loop/lid; other site
365044004104	ABC transporter signature motif; other site
365044004105	Walker B; other site
365044004106	D-loop; other site
365044004107	H-loop/switch region; other site
365044004108	TOBE domain; Region: TOBE_2; pfam08402
365044004109	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
365044004110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044004111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044004112	dimer interface [polypeptide binding]; other site
365044004113	conserved gate region; other site
365044004114	putative PBP binding loops; other site
365044004115	ABC-ATPase subunit interface; other site
365044004116	hypothetical protein; Provisional; Region: PRK10428
365044004117	PAS fold; Region: PAS_4; pfam08448
365044004118	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044004119	GAF domain; Region: GAF; pfam01590
365044004120	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044004121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044004122	dimer interface [polypeptide binding]; other site
365044004123	phosphorylation site [posttranslational modification]
365044004124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004125	ATP binding site [chemical binding]; other site
365044004126	Mg2+ binding site [ion binding]; other site
365044004127	G-X-G motif; other site
365044004128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004129	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004130	active site
365044004131	phosphorylation site [posttranslational modification]
365044004132	intermolecular recognition site; other site
365044004133	dimerization interface [polypeptide binding]; other site
365044004134	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
365044004135	Family of unknown function (DUF490); Region: DUF490; pfam04357
365044004136	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
365044004137	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
365044004138	Surface antigen; Region: Bac_surface_Ag; pfam01103
365044004139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
365044004140	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365044004141	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044004142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044004143	Walker A motif; other site
365044004144	ATP binding site [chemical binding]; other site
365044004145	Walker B motif; other site
365044004146	arginine finger; other site
365044004147	Cytochrome c553 [Energy production and conversion]; Region: COG2863
365044004148	Cytochrome c; Region: Cytochrom_C; cl11414
365044004149	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
365044004150	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
365044004151	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
365044004152	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044004153	Coenzyme A transferase; Region: CoA_trans; cl17247
365044004154	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
365044004155	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
365044004156	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044004157	dimer interface [polypeptide binding]; other site
365044004158	active site
365044004159	classical (c) SDRs; Region: SDR_c; cd05233
365044004160	short chain dehydrogenase; Provisional; Region: PRK07577
365044004161	NAD(P) binding site [chemical binding]; other site
365044004162	active site
365044004163	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004164	Predicted membrane protein [Function unknown]; Region: COG2860
365044004165	UPF0126 domain; Region: UPF0126; pfam03458
365044004166	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044004167	Winged helix-turn helix; Region: HTH_29; pfam13551
365044004168	Winged helix-turn helix; Region: HTH_33; pfam13592
365044004169	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044004170	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
365044004171	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
365044004172	TrkA-N domain; Region: TrkA_N; pfam02254
365044004173	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
365044004174	putative active site [active]
365044004175	putative catalytic site [active]
365044004176	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
365044004177	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
365044004178	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
365044004179	Methyltransferase domain; Region: Methyltransf_12; pfam08242
365044004180	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
365044004181	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168
365044004182	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
365044004183	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
365044004184	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044004185	Cytochrome c; Region: Cytochrom_C; pfam00034
365044004186	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
365044004187	Subunit I/III interface [polypeptide binding]; other site
365044004188	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
365044004189	D-pathway; other site
365044004190	Subunit I/VIIc interface [polypeptide binding]; other site
365044004191	Subunit I/IV interface [polypeptide binding]; other site
365044004192	Subunit I/II interface [polypeptide binding]; other site
365044004193	Low-spin heme (heme a) binding site [chemical binding]; other site
365044004194	Subunit I/VIIa interface [polypeptide binding]; other site
365044004195	Subunit I/VIa interface [polypeptide binding]; other site
365044004196	Dimer interface; other site
365044004197	Putative water exit pathway; other site
365044004198	Binuclear center (heme a3/CuB) [ion binding]; other site
365044004199	K-pathway; other site
365044004200	Subunit I/Vb interface [polypeptide binding]; other site
365044004201	Putative proton exit pathway; other site
365044004202	Subunit I/VIb interface; other site
365044004203	Subunit I/VIc interface [polypeptide binding]; other site
365044004204	Electron transfer pathway; other site
365044004205	Subunit I/VIIIb interface [polypeptide binding]; other site
365044004206	Subunit I/VIIb interface [polypeptide binding]; other site
365044004207	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
365044004208	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
365044004209	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
365044004210	Subunit III/VIIa interface [polypeptide binding]; other site
365044004211	Phospholipid binding site [chemical binding]; other site
365044004212	Subunit I/III interface [polypeptide binding]; other site
365044004213	Subunit III/VIb interface [polypeptide binding]; other site
365044004214	Subunit III/VIa interface; other site
365044004215	Subunit III/Vb interface [polypeptide binding]; other site
365044004216	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
365044004217	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
365044004218	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
365044004219	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
365044004220	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
365044004221	UbiA prenyltransferase family; Region: UbiA; pfam01040
365044004222	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
365044004223	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
365044004224	Cu(I) binding site [ion binding]; other site
365044004225	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
365044004226	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044004227	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
365044004228	DNA binding residues [nucleotide binding]
365044004229	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
365044004230	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
365044004231	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044004232	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
365044004233	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
365044004234	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
365044004235	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
365044004236	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
365044004237	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
365044004238	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
365044004239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004240	S-adenosylmethionine binding site [chemical binding]; other site
365044004241	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
365044004242	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
365044004243	active site
365044004244	(T/H)XGH motif; other site
365044004245	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044004246	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
365044004247	putative active site [active]
365044004248	catalytic residue [active]
365044004249	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
365044004250	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
365044004251	5S rRNA interface [nucleotide binding]; other site
365044004252	CTC domain interface [polypeptide binding]; other site
365044004253	L16 interface [polypeptide binding]; other site
365044004254	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
365044004255	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
365044004256	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044004257	active site
365044004258	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
365044004259	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
365044004260	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
365044004261	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
365044004262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044004263	binding surface
365044004264	TPR motif; other site
365044004265	TPR repeat; Region: TPR_11; pfam13414
365044004266	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
365044004267	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
365044004268	DNA binding site [nucleotide binding]
365044004269	catalytic residue [active]
365044004270	H2TH interface [polypeptide binding]; other site
365044004271	putative catalytic residues [active]
365044004272	turnover-facilitating residue; other site
365044004273	intercalation triad [nucleotide binding]; other site
365044004274	8OG recognition residue [nucleotide binding]; other site
365044004275	putative reading head residues; other site
365044004276	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
365044004277	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
365044004278	Dynamin family; Region: Dynamin_N; pfam00350
365044004279	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365044004280	G1 box; other site
365044004281	GTP/Mg2+ binding site [chemical binding]; other site
365044004282	G2 box; other site
365044004283	Switch I region; other site
365044004284	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
365044004285	G3 box; other site
365044004286	Switch II region; other site
365044004287	GTP/Mg2+ binding site [chemical binding]; other site
365044004288	G4 box; other site
365044004289	G5 box; other site
365044004290	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
365044004291	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044004292	minor groove reading motif; other site
365044004293	helix-hairpin-helix signature motif; other site
365044004294	substrate binding pocket [chemical binding]; other site
365044004295	active site
365044004296	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
365044004297	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
365044004298	DNA binding and oxoG recognition site [nucleotide binding]
365044004299	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
365044004300	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
365044004301	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
365044004302	Walker A/P-loop; other site
365044004303	ATP binding site [chemical binding]; other site
365044004304	Q-loop/lid; other site
365044004305	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
365044004306	ABC transporter signature motif; other site
365044004307	Walker B; other site
365044004308	D-loop; other site
365044004309	H-loop/switch region; other site
365044004310	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
365044004311	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
365044004312	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
365044004313	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
365044004314	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
365044004315	nudix motif; other site
365044004316	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
365044004317	putative active site [active]
365044004318	catalytic site [active]
365044004319	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
365044004320	PLD-like domain; Region: PLDc_2; pfam13091
365044004321	putative active site [active]
365044004322	catalytic site [active]
365044004323	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
365044004324	active site
365044004325	Sensors of blue-light using FAD; Region: BLUF; pfam04940
365044004326	BON domain; Region: BON; pfam04972
365044004327	BON domain; Region: BON; pfam04972
365044004328	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
365044004329	CHASE3 domain; Region: CHASE3; pfam05227
365044004330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365044004331	Histidine kinase; Region: HisKA_3; pfam07730
365044004332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004333	ATP binding site [chemical binding]; other site
365044004334	Mg2+ binding site [ion binding]; other site
365044004335	G-X-G motif; other site
365044004336	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044004337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004338	active site
365044004339	phosphorylation site [posttranslational modification]
365044004340	intermolecular recognition site; other site
365044004341	dimerization interface [polypeptide binding]; other site
365044004342	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044004343	DNA binding residues [nucleotide binding]
365044004344	dimerization interface [polypeptide binding]; other site
365044004345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004346	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004347	active site
365044004348	phosphorylation site [posttranslational modification]
365044004349	intermolecular recognition site; other site
365044004350	dimerization interface [polypeptide binding]; other site
365044004351	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
365044004352	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
365044004353	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
365044004354	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
365044004355	ATP binding site [chemical binding]; other site
365044004356	substrate interface [chemical binding]; other site
365044004357	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
365044004358	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
365044004359	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
365044004360	protein binding site [polypeptide binding]; other site
365044004361	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
365044004362	Catalytic dyad [active]
365044004363	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044004364	catalytic core [active]
365044004365	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044004366	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
365044004367	active site residue [active]
365044004368	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
365044004369	GSH binding site [chemical binding]; other site
365044004370	catalytic residues [active]
365044004371	preprotein translocase subunit SecB; Validated; Region: PRK05751
365044004372	SecA binding site; other site
365044004373	Preprotein binding site; other site
365044004374	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
365044004375	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
365044004376	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
365044004377	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
365044004378	pantoate--beta-alanine ligase; Region: panC; TIGR00018
365044004379	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
365044004380	active site
365044004381	nucleotide binding site [chemical binding]; other site
365044004382	HIGH motif; other site
365044004383	KMSKS motif; other site
365044004384	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
365044004385	oligomerization interface [polypeptide binding]; other site
365044004386	active site
365044004387	metal binding site [ion binding]; metal-binding site
365044004388	Short C-terminal domain; Region: SHOCT; pfam09851
365044004389	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
365044004390	tetramerization interface [polypeptide binding]; other site
365044004391	active site
365044004392	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
365044004393	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
365044004394	dimerization interface [polypeptide binding]; other site
365044004395	active site
365044004396	quinolinate synthetase; Provisional; Region: PRK09375
365044004397	aminodeoxychorismate synthase; Provisional; Region: PRK07508
365044004398	chorismate binding enzyme; Region: Chorismate_bind; cl10555
365044004399	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
365044004400	substrate-cofactor binding pocket; other site
365044004401	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
365044004402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044004403	preprotein translocase subunit SecB; Validated; Region: PRK05751
365044004404	SecA binding site; other site
365044004405	Preprotein binding site; other site
365044004406	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
365044004407	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
365044004408	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
365044004409	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
365044004410	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
365044004411	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044004412	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
365044004413	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044004414	GAF domain; Region: GAF; pfam01590
365044004415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044004416	Walker A motif; other site
365044004417	ATP binding site [chemical binding]; other site
365044004418	Walker B motif; other site
365044004419	arginine finger; other site
365044004420	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044004421	DTW domain; Region: DTW; cl01221
365044004422	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
365044004423	Coenzyme A transferase; Region: CoA_trans; cl17247
365044004424	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
365044004425	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
365044004426	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
365044004427	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
365044004428	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
365044004429	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
365044004430	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
365044004431	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
365044004432	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
365044004433	Malonate transporter MadL subunit; Region: MadL; pfam03817
365044004434	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044004436	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
365044004437	putative dimerization interface [polypeptide binding]; other site
365044004438	L-aspartate oxidase; Provisional; Region: PRK09077
365044004439	L-aspartate oxidase; Provisional; Region: PRK06175
365044004440	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
365044004441	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
365044004442	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
365044004443	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
365044004444	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
365044004445	putative transporter; Provisional; Region: PRK11660
365044004446	Sulfate transporter family; Region: Sulfate_transp; pfam00916
365044004447	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
365044004448	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
365044004449	oligomer interface [polypeptide binding]; other site
365044004450	active site residues [active]
365044004451	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
365044004452	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
365044004453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
365044004454	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044004455	active site
365044004456	metal binding site [ion binding]; metal-binding site
365044004457	interdomain interaction site; other site
365044004458	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
365044004459	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365044004460	active site
365044004461	Int/Topo IB signature motif; other site
365044004462	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044004463	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
365044004464	UreF; Region: UreF; pfam01730
365044004465	urease accessory protein UreE; Provisional; Region: ureE; PRK13263
365044004466	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
365044004467	dimer interface [polypeptide binding]; other site
365044004468	catalytic residues [active]
365044004469	urease subunit alpha; Reviewed; Region: ureC; PRK13207
365044004470	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
365044004471	subunit interactions [polypeptide binding]; other site
365044004472	active site
365044004473	flap region; other site
365044004474	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
365044004475	gamma-beta subunit interface [polypeptide binding]; other site
365044004476	alpha-beta subunit interface [polypeptide binding]; other site
365044004477	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
365044004478	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
365044004479	alpha-gamma subunit interface [polypeptide binding]; other site
365044004480	beta-gamma subunit interface [polypeptide binding]; other site
365044004481	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
365044004482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044004483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044004484	dimer interface [polypeptide binding]; other site
365044004485	phosphorylation site [posttranslational modification]
365044004486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004487	ATP binding site [chemical binding]; other site
365044004488	Mg2+ binding site [ion binding]; other site
365044004489	G-X-G motif; other site
365044004490	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044004491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004492	active site
365044004493	phosphorylation site [posttranslational modification]
365044004494	intermolecular recognition site; other site
365044004495	dimerization interface [polypeptide binding]; other site
365044004496	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004498	active site
365044004499	phosphorylation site [posttranslational modification]
365044004500	intermolecular recognition site; other site
365044004501	dimerization interface [polypeptide binding]; other site
365044004502	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044004503	DNA binding residues [nucleotide binding]
365044004504	dimerization interface [polypeptide binding]; other site
365044004505	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
365044004506	rRNA binding site [nucleotide binding]; other site
365044004507	predicted 30S ribosome binding site; other site
365044004508	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
365044004509	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
365044004510	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
365044004511	DEAD/DEAH box helicase; Region: DEAD; pfam00270
365044004512	DEAD_2; Region: DEAD_2; pfam06733
365044004513	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
365044004514	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
365044004515	EF-hand domain pair; Region: EF_hand_5; pfam13499
365044004516	Ca2+ binding site [ion binding]; other site
365044004517	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365044004518	Domain of unknown function DUF20; Region: UPF0118; pfam01594
365044004519	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
365044004520	putative catalytic site [active]
365044004521	putative metal binding site [ion binding]; other site
365044004522	putative phosphate binding site [ion binding]; other site
365044004523	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
365044004524	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
365044004525	active site residues [active]
365044004526	dimer interface [polypeptide binding]; other site
365044004527	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
365044004528	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
365044004529	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
365044004530	EthD domain; Region: EthD; cl17553
365044004531	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
365044004532	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
365044004533	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
365044004534	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044004535	AAA ATPase domain; Region: AAA_15; pfam13175
365044004536	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044004537	Walker A/P-loop; other site
365044004538	ATP binding site [chemical binding]; other site
365044004539	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365044004540	putative active site [active]
365044004541	putative metal-binding site [ion binding]; other site
365044004542	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044004543	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
365044004544	putative ligand binding site [chemical binding]; other site
365044004545	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044004546	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044004547	TM-ABC transporter signature motif; other site
365044004548	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044004549	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044004550	TM-ABC transporter signature motif; other site
365044004551	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
365044004552	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044004553	Walker A/P-loop; other site
365044004554	ATP binding site [chemical binding]; other site
365044004555	Q-loop/lid; other site
365044004556	ABC transporter signature motif; other site
365044004557	Walker B; other site
365044004558	D-loop; other site
365044004559	H-loop/switch region; other site
365044004560	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
365044004561	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044004562	Walker A/P-loop; other site
365044004563	ATP binding site [chemical binding]; other site
365044004564	Q-loop/lid; other site
365044004565	ABC transporter signature motif; other site
365044004566	Walker B; other site
365044004567	D-loop; other site
365044004568	H-loop/switch region; other site
365044004569	UreD urease accessory protein; Region: UreD; pfam01774
365044004570	cyanophycin synthetase; Provisional; Region: PRK14016
365044004571	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365044004572	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044004573	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044004574	cyanophycin synthetase; Provisional; Region: PRK14016
365044004575	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365044004576	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
365044004577	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365044004578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044004579	Walker A/P-loop; other site
365044004580	ATP binding site [chemical binding]; other site
365044004581	Q-loop/lid; other site
365044004582	ABC transporter signature motif; other site
365044004583	Walker B; other site
365044004584	D-loop; other site
365044004585	H-loop/switch region; other site
365044004586	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
365044004587	malic enzyme; Reviewed; Region: PRK12862
365044004588	Malic enzyme, N-terminal domain; Region: malic; pfam00390
365044004589	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
365044004590	putative NAD(P) binding site [chemical binding]; other site
365044004591	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
365044004592	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004593	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
365044004594	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
365044004595	XdhC Rossmann domain; Region: XdhC_C; pfam13478
365044004596	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044004597	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044004598	putative ligand binding site [chemical binding]; other site
365044004599	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004600	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044004601	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
365044004602	putative effector binding pocket; other site
365044004603	putative dimerization interface [polypeptide binding]; other site
365044004604	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
365044004605	tartrate dehydrogenase; Region: TTC; TIGR02089
365044004606	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004607	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
365044004608	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
365044004609	MOFRL family; Region: MOFRL; pfam05161
365044004610	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004611	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
365044004612	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
365044004613	phosphate binding site [ion binding]; other site
365044004614	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004615	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044004616	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044004617	NAD(P) binding site [chemical binding]; other site
365044004618	catalytic residues [active]
365044004619	benzoylformate decarboxylase; Reviewed; Region: PRK07092
365044004620	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365044004621	PYR/PP interface [polypeptide binding]; other site
365044004622	dimer interface [polypeptide binding]; other site
365044004623	TPP binding site [chemical binding]; other site
365044004624	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
365044004625	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
365044004626	TPP-binding site [chemical binding]; other site
365044004627	dimer interface [polypeptide binding]; other site
365044004628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044004630	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
365044004631	substrate binding pocket [chemical binding]; other site
365044004632	dimerization interface [polypeptide binding]; other site
365044004633	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044004634	apolar tunnel; other site
365044004635	heme binding site [chemical binding]; other site
365044004636	dimerization interface [polypeptide binding]; other site
365044004637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004638	S-adenosylmethionine binding site [chemical binding]; other site
365044004639	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
365044004640	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044004641	non-specific DNA binding site [nucleotide binding]; other site
365044004642	salt bridge; other site
365044004643	sequence-specific DNA binding site [nucleotide binding]; other site
365044004644	Cupin domain; Region: Cupin_2; pfam07883
365044004645	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044004646	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044004647	substrate binding pocket [chemical binding]; other site
365044004648	membrane-bound complex binding site; other site
365044004649	hinge residues; other site
365044004650	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
365044004651	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365044004652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044004653	dimer interface [polypeptide binding]; other site
365044004654	conserved gate region; other site
365044004655	putative PBP binding loops; other site
365044004656	ABC-ATPase subunit interface; other site
365044004657	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044004658	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365044004659	Walker A/P-loop; other site
365044004660	ATP binding site [chemical binding]; other site
365044004661	Q-loop/lid; other site
365044004662	ABC transporter signature motif; other site
365044004663	Walker B; other site
365044004664	D-loop; other site
365044004665	H-loop/switch region; other site
365044004666	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044004667	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
365044004668	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
365044004669	Methyltransferase domain; Region: Methyltransf_23; pfam13489
365044004670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004671	S-adenosylmethionine binding site [chemical binding]; other site
365044004672	Cytochrome c; Region: Cytochrom_C; cl11414
365044004673	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
365044004674	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
365044004675	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
365044004676	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
365044004677	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
365044004678	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
365044004679	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
365044004680	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
365044004681	Walker A/P-loop; other site
365044004682	ATP binding site [chemical binding]; other site
365044004683	Q-loop/lid; other site
365044004684	ABC transporter signature motif; other site
365044004685	Walker B; other site
365044004686	D-loop; other site
365044004687	H-loop/switch region; other site
365044004688	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
365044004689	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044004690	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
365044004691	TM-ABC transporter signature motif; other site
365044004692	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
365044004693	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044004694	TM-ABC transporter signature motif; other site
365044004695	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
365044004696	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
365044004697	putative ligand binding site [chemical binding]; other site
365044004698	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
365044004699	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
365044004700	active site
365044004701	purine riboside binding site [chemical binding]; other site
365044004702	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
365044004703	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
365044004704	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
365044004705	putative ligand binding site [chemical binding]; other site
365044004706	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
365044004707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044004708	FeS/SAM binding site; other site
365044004709	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
365044004710	active site
365044004711	guanine deaminase; Provisional; Region: PRK09228
365044004712	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044004713	active site
365044004714	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
365044004715	trimer interface [polypeptide binding]; other site
365044004716	active site
365044004717	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
365044004718	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
365044004719	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
365044004720	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
365044004721	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
365044004722	Predicted metalloprotease [General function prediction only]; Region: COG2321
365044004723	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
365044004724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044004725	Probable transposase; Region: OrfB_IS605; pfam01385
365044004726	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044004727	UDP-glucose 4-epimerase; Region: PLN02240
365044004728	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
365044004729	NAD binding site [chemical binding]; other site
365044004730	homodimer interface [polypeptide binding]; other site
365044004731	active site
365044004732	substrate binding site [chemical binding]; other site
365044004733	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044004734	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044004735	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004736	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044004737	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044004738	Short C-terminal domain; Region: SHOCT; pfam09851
365044004739	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044004740	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004741	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044004742	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
365044004743	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
365044004744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
365044004745	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044004746	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004747	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044004748	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
365044004749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
365044004750	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
365044004751	AMP binding site [chemical binding]; other site
365044004752	metal binding site [ion binding]; metal-binding site
365044004753	active site
365044004754	aminopeptidase N; Provisional; Region: pepN; PRK14015
365044004755	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
365044004756	active site
365044004757	Zn binding site [ion binding]; other site
365044004758	peptide chain release factor 2; Validated; Region: prfB; PRK00578
365044004759	This domain is found in peptide chain release factors; Region: PCRF; smart00937
365044004760	RF-1 domain; Region: RF-1; pfam00472
365044004761	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004763	active site
365044004764	phosphorylation site [posttranslational modification]
365044004765	intermolecular recognition site; other site
365044004766	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044004767	dimerization interface [polypeptide binding]; other site
365044004768	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044004769	dimer interface [polypeptide binding]; other site
365044004770	phosphorylation site [posttranslational modification]
365044004771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004772	ATP binding site [chemical binding]; other site
365044004773	Mg2+ binding site [ion binding]; other site
365044004774	G-X-G motif; other site
365044004775	CheB methylesterase; Region: CheB_methylest; pfam01339
365044004776	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
365044004777	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
365044004778	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
365044004779	CHASE3 domain; Region: CHASE3; pfam05227
365044004780	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044004781	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
365044004782	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
365044004783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004784	ATP binding site [chemical binding]; other site
365044004785	Mg2+ binding site [ion binding]; other site
365044004786	G-X-G motif; other site
365044004787	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004789	active site
365044004790	phosphorylation site [posttranslational modification]
365044004791	intermolecular recognition site; other site
365044004792	dimerization interface [polypeptide binding]; other site
365044004793	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004795	active site
365044004796	phosphorylation site [posttranslational modification]
365044004797	intermolecular recognition site; other site
365044004798	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004800	active site
365044004801	phosphorylation site [posttranslational modification]
365044004802	intermolecular recognition site; other site
365044004803	dimerization interface [polypeptide binding]; other site
365044004804	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365044004805	Lipase (class 2); Region: Lipase_2; pfam01674
365044004806	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
365044004807	catalytic site [active]
365044004808	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
365044004809	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044004810	ligand binding site [chemical binding]; other site
365044004811	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365044004812	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
365044004813	active site
365044004814	catalytic tetrad [active]
365044004815	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
365044004816	putative deacylase active site [active]
365044004817	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
365044004818	Predicted aspartyl protease [General function prediction only]; Region: COG3577
365044004819	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
365044004820	catalytic motif [active]
365044004821	Catalytic residue [active]
365044004822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
365044004823	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
365044004824	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
365044004825	FAD binding domain; Region: FAD_binding_4; pfam01565
365044004826	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
365044004827	argininosuccinate synthase; Validated; Region: PRK05370
365044004828	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
365044004829	RNA polymerase sigma factor; Provisional; Region: PRK12514
365044004830	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044004831	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044004832	DNA binding residues [nucleotide binding]
365044004833	Anti-sigma-K factor rskA; Region: RskA; pfam10099
365044004834	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
365044004835	ArsC family; Region: ArsC; pfam03960
365044004836	putative catalytic residues [active]
365044004837	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
365044004838	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
365044004839	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044004840	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044004841	Sporulation related domain; Region: SPOR; pfam05036
365044004842	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
365044004843	Colicin V production protein; Region: Colicin_V; pfam02674
365044004844	amidophosphoribosyltransferase; Provisional; Region: PRK09246
365044004845	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
365044004846	active site
365044004847	tetramer interface [polypeptide binding]; other site
365044004848	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044004849	active site
365044004850	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
365044004851	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365044004852	homodimer interface [polypeptide binding]; other site
365044004853	substrate-cofactor binding pocket; other site
365044004854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044004855	catalytic residue [active]
365044004856	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
365044004857	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
365044004858	active site
365044004859	HIGH motif; other site
365044004860	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
365044004861	active site
365044004862	KMSKS motif; other site
365044004863	Uncharacterized conserved protein [Function unknown]; Region: COG4279
365044004864	SNF2 Helicase protein; Region: DUF3670; pfam12419
365044004865	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
365044004866	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044004867	ATP binding site [chemical binding]; other site
365044004868	putative Mg++ binding site [ion binding]; other site
365044004869	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044004870	nucleotide binding region [chemical binding]; other site
365044004871	ATP-binding site [chemical binding]; other site
365044004872	Ion channel; Region: Ion_trans_2; pfam07885
365044004873	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
365044004874	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
365044004875	EamA-like transporter family; Region: EamA; pfam00892
365044004876	EamA-like transporter family; Region: EamA; pfam00892
365044004877	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
365044004878	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
365044004879	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
365044004880	DNA binding site [nucleotide binding]
365044004881	active site
365044004882	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
365044004883	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
365044004884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044004885	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044004886	AlkA N-terminal domain; Region: AlkA_N; pfam06029
365044004887	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
365044004888	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044004889	minor groove reading motif; other site
365044004890	helix-hairpin-helix signature motif; other site
365044004891	active site
365044004892	4-alpha-glucanotransferase; Provisional; Region: PRK14508
365044004893	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
365044004894	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
365044004895	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
365044004896	active site
365044004897	catalytic site [active]
365044004898	glycogen branching enzyme; Provisional; Region: PRK05402
365044004899	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
365044004900	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
365044004901	active site
365044004902	catalytic site [active]
365044004903	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
365044004904	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
365044004905	homodimer interface [polypeptide binding]; other site
365044004906	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
365044004907	active site pocket [active]
365044004908	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
365044004909	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
365044004910	ligand binding site; other site
365044004911	oligomer interface; other site
365044004912	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
365044004913	dimer interface [polypeptide binding]; other site
365044004914	N-terminal domain interface [polypeptide binding]; other site
365044004915	sulfate 1 binding site; other site
365044004916	glycogen synthase; Provisional; Region: glgA; PRK00654
365044004917	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
365044004918	ADP-binding pocket [chemical binding]; other site
365044004919	homodimer interface [polypeptide binding]; other site
365044004920	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
365044004921	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
365044004922	active site
365044004923	substrate binding site [chemical binding]; other site
365044004924	metal binding site [ion binding]; metal-binding site
365044004925	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
365044004926	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
365044004927	putative active site [active]
365044004928	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
365044004929	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
365044004930	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365044004931	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
365044004932	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
365044004933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044004934	NAD(P) binding site [chemical binding]; other site
365044004935	active site
365044004936	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
365044004937	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044004938	classical (c) SDRs; Region: SDR_c; cd05233
365044004939	NAD(P) binding site [chemical binding]; other site
365044004940	active site
365044004941	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
365044004942	cofactor binding site; other site
365044004943	metal binding site [ion binding]; metal-binding site
365044004944	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
365044004945	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
365044004946	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044004947	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
365044004948	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044004949	Zn binding site [ion binding]; other site
365044004950	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
365044004951	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
365044004952	dimer interface [polypeptide binding]; other site
365044004953	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
365044004954	active site
365044004955	Fe binding site [ion binding]; other site
365044004956	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044004957	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044004958	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044004959	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044004960	active site
365044004961	catalytic residues [active]
365044004962	metal binding site [ion binding]; metal-binding site
365044004963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044004965	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
365044004966	putative dimerization interface [polypeptide binding]; other site
365044004967	tellurium resistance terB-like protein; Region: terB_like; cd07177
365044004968	metal binding site [ion binding]; metal-binding site
365044004969	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
365044004970	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044004971	active site residue [active]
365044004972	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
365044004973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004974	S-adenosylmethionine binding site [chemical binding]; other site
365044004975	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044004976	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044004977	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
365044004978	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
365044004979	active site
365044004980	tetramer interface [polypeptide binding]; other site
365044004981	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044004982	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044004983	DNA binding site [nucleotide binding]
365044004984	domain linker motif; other site
365044004985	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
365044004986	putative dimerization interface [polypeptide binding]; other site
365044004987	putative ligand binding site [chemical binding]; other site
365044004988	Uncharacterized conserved protein [Function unknown]; Region: COG1434
365044004989	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
365044004990	putative active site [active]
365044004991	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
365044004992	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044004993	FAD binding site [chemical binding]; other site
365044004994	substrate binding pocket [chemical binding]; other site
365044004995	catalytic base [active]
365044004996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044004997	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
365044004998	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448
365044004999	putative dimerization interface [polypeptide binding]; other site
365044005000	putative substrate binding pocket [chemical binding]; other site
365044005001	methionine sulfoxide reductase A; Provisional; Region: PRK14054
365044005002	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
365044005003	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044005004	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535
365044005005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044005006	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044005007	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044005008	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535
365044005009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044005010	AAA domain; Region: AAA_23; pfam13476
365044005011	AAA domain; Region: AAA_21; pfam13304
365044005012	Walker A/P-loop; other site
365044005013	ATP binding site [chemical binding]; other site
365044005014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044005015	Q-loop/lid; other site
365044005016	ABC transporter signature motif; other site
365044005017	Walker B; other site
365044005018	D-loop; other site
365044005019	H-loop/switch region; other site
365044005020	FOG: CBS domain [General function prediction only]; Region: COG0517
365044005021	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
365044005022	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
365044005023	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
365044005024	metal binding site [ion binding]; metal-binding site
365044005025	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
365044005026	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
365044005027	ABC-ATPase subunit  interface; other site
365044005028	dimer interface [polypeptide binding]; other site
365044005029	putative PBP binding regions; other site
365044005030	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
365044005031	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
365044005032	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
365044005033	metal binding site 2 [ion binding]; metal-binding site
365044005034	putative DNA binding helix; other site
365044005035	metal binding site 1 [ion binding]; metal-binding site
365044005036	structural Zn2+ binding site [ion binding]; other site
365044005037	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
365044005038	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044005039	Walker A/P-loop; other site
365044005040	ATP binding site [chemical binding]; other site
365044005041	Q-loop/lid; other site
365044005042	ABC transporter signature motif; other site
365044005043	Walker B; other site
365044005044	D-loop; other site
365044005045	H-loop/switch region; other site
365044005046	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044005047	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
365044005048	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
365044005049	Protein of unknown function, DUF486; Region: DUF486; pfam04342
365044005050	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
365044005051	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
365044005052	FtsX-like permease family; Region: FtsX; pfam02687
365044005053	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044005054	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044005055	Walker A/P-loop; other site
365044005056	ATP binding site [chemical binding]; other site
365044005057	Q-loop/lid; other site
365044005058	ABC transporter signature motif; other site
365044005059	Walker B; other site
365044005060	D-loop; other site
365044005061	H-loop/switch region; other site
365044005062	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
365044005063	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
365044005064	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044005065	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
365044005066	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
365044005067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044005068	ATP binding site [chemical binding]; other site
365044005069	Mg2+ binding site [ion binding]; other site
365044005070	G-X-G motif; other site
365044005071	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
365044005072	ATP binding site [chemical binding]; other site
365044005073	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
365044005074	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
365044005075	beta-ketothiolase; Provisional; Region: PRK09051
365044005076	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044005077	dimer interface [polypeptide binding]; other site
365044005078	active site
365044005079	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
365044005080	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044005081	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
365044005082	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
365044005083	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
365044005084	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044005085	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
365044005086	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
365044005087	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
365044005088	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
365044005089	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044005090	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
365044005091	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044005092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044005093	Walker A motif; other site
365044005094	ATP binding site [chemical binding]; other site
365044005095	Walker B motif; other site
365044005096	arginine finger; other site
365044005097	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044005098	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
365044005099	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
365044005100	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044005101	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044005102	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
365044005103	acyl-activating enzyme (AAE) consensus motif; other site
365044005104	acyl-activating enzyme (AAE) consensus motif; other site
365044005105	putative AMP binding site [chemical binding]; other site
365044005106	putative active site [active]
365044005107	putative CoA binding site [chemical binding]; other site
365044005108	AMIN domain; Region: AMIN; pfam11741
365044005109	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
365044005110	active site
365044005111	metal binding site [ion binding]; metal-binding site
365044005112	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
365044005113	epoxyqueuosine reductase; Region: TIGR00276
365044005114	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
365044005115	Predicted permeases [General function prediction only]; Region: COG0679
365044005116	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
365044005117	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044005118	active site
365044005119	DNA binding site [nucleotide binding]
365044005120	Int/Topo IB signature motif; other site
365044005121	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
365044005122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044005123	S-adenosylmethionine binding site [chemical binding]; other site
365044005124	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
365044005125	dinuclear metal binding motif [ion binding]; other site
365044005126	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
365044005127	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
365044005128	trimer interface [polypeptide binding]; other site
365044005129	putative metal binding site [ion binding]; other site
365044005130	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
365044005131	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
365044005132	dimerization interface [polypeptide binding]; other site
365044005133	domain crossover interface; other site
365044005134	redox-dependent activation switch; other site
365044005135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
365044005136	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
365044005137	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
365044005138	Septum formation initiator; Region: DivIC; cl17659
365044005139	enolase; Provisional; Region: eno; PRK00077
365044005140	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
365044005141	dimer interface [polypeptide binding]; other site
365044005142	metal binding site [ion binding]; metal-binding site
365044005143	substrate binding pocket [chemical binding]; other site
365044005144	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
365044005145	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365044005146	CTP synthetase; Validated; Region: pyrG; PRK05380
365044005147	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
365044005148	Catalytic site [active]
365044005149	active site
365044005150	UTP binding site [chemical binding]; other site
365044005151	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
365044005152	active site
365044005153	putative oxyanion hole; other site
365044005154	catalytic triad [active]
365044005155	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
365044005156	Flavoprotein; Region: Flavoprotein; pfam02441
365044005157	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
365044005158	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
365044005159	trimer interface [polypeptide binding]; other site
365044005160	active site
365044005161	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
365044005162	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
365044005163	Uncharacterized conserved protein [Function unknown]; Region: COG2850
365044005164	Cupin domain; Region: Cupin_2; cl17218
365044005165	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
365044005166	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
365044005167	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
365044005168	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
365044005169	dihydrodipicolinate synthase; Region: dapA; TIGR00674
365044005170	dimer interface [polypeptide binding]; other site
365044005171	active site
365044005172	catalytic residue [active]
365044005173	Methyltransferase domain; Region: Methyltransf_25; pfam13649
365044005174	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044005175	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005176	putative substrate translocation pore; other site
365044005177	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
365044005178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044005179	ATP binding site [chemical binding]; other site
365044005180	Mg2+ binding site [ion binding]; other site
365044005181	G-X-G motif; other site
365044005182	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
365044005183	anchoring element; other site
365044005184	dimer interface [polypeptide binding]; other site
365044005185	ATP binding site [chemical binding]; other site
365044005186	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
365044005187	active site
365044005188	metal binding site [ion binding]; metal-binding site
365044005189	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
365044005190	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
365044005191	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044005192	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044005193	catalytic residue [active]
365044005194	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
365044005195	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
365044005196	CAP-like domain; other site
365044005197	active site
365044005198	primary dimer interface [polypeptide binding]; other site
365044005199	Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598
365044005200	Zn binding site [ion binding]; other site
365044005201	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
365044005202	amidase catalytic site [active]
365044005203	Zn binding residues [ion binding]; other site
365044005204	substrate binding site [chemical binding]; other site
365044005205	Caspase domain; Region: Peptidase_C14; pfam00656
365044005206	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
365044005207	homotrimer interaction site [polypeptide binding]; other site
365044005208	putative active site [active]
365044005209	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
365044005210	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
365044005211	Competence protein; Region: Competence; pfam03772
365044005212	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
365044005213	Uncharacterized conserved protein [Function unknown]; Region: COG2308
365044005214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
365044005215	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
365044005216	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044005217	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044005218	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044005219	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
365044005220	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
365044005221	putative active site [active]
365044005222	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044005223	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
365044005224	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
365044005225	NADP binding site [chemical binding]; other site
365044005226	dimer interface [polypeptide binding]; other site
365044005227	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
365044005228	Part of AAA domain; Region: AAA_19; pfam13245
365044005229	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
365044005230	AAA domain; Region: AAA_12; pfam13087
365044005231	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044005232	putative active site [active]
365044005233	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
365044005234	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
365044005235	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044005236	oligomeric interface; other site
365044005237	putative active site [active]
365044005238	homodimer interface [polypeptide binding]; other site
365044005239	KWG Leptospira; Region: KWG; pfam07656
365044005240	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
365044005241	Transglycosylase SLT domain; Region: SLT_2; pfam13406
365044005242	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044005243	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044005244	catalytic residue [active]
365044005245	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
365044005246	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044005247	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044005248	Protein of unknown function DUF58; Region: DUF58; pfam01882
365044005249	MoxR-like ATPases [General function prediction only]; Region: COG0714
365044005250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044005251	Walker A motif; other site
365044005252	ATP binding site [chemical binding]; other site
365044005253	Walker B motif; other site
365044005254	arginine finger; other site
365044005255	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
365044005256	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
365044005257	putative active site [active]
365044005258	Zn binding site [ion binding]; other site
365044005259	enoyl-CoA hydratase; Validated; Region: PRK08139
365044005260	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044005261	substrate binding site [chemical binding]; other site
365044005262	oxyanion hole (OAH) forming residues; other site
365044005263	trimer interface [polypeptide binding]; other site
365044005264	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
365044005265	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365044005266	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
365044005267	Ligand binding site [chemical binding]; other site
365044005268	Electron transfer flavoprotein domain; Region: ETF; pfam01012
365044005269	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
365044005270	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
365044005271	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
365044005272	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
365044005273	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
365044005274	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044005275	active site
365044005276	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
365044005277	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
365044005278	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365044005279	FMN binding site [chemical binding]; other site
365044005280	substrate binding site [chemical binding]; other site
365044005281	putative catalytic residue [active]
365044005282	putative metal dependent hydrolase; Provisional; Region: PRK11598
365044005283	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
365044005284	Sulfatase; Region: Sulfatase; pfam00884
365044005285	S-formylglutathione hydrolase; Region: PLN02442
365044005286	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
365044005287	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
365044005288	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
365044005289	substrate binding site [chemical binding]; other site
365044005290	catalytic Zn binding site [ion binding]; other site
365044005291	NAD binding site [chemical binding]; other site
365044005292	structural Zn binding site [ion binding]; other site
365044005293	dimer interface [polypeptide binding]; other site
365044005294	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044005295	RNA binding surface [nucleotide binding]; other site
365044005296	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
365044005297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044005298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044005299	dimer interface [polypeptide binding]; other site
365044005300	phosphorylation site [posttranslational modification]
365044005301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044005302	ATP binding site [chemical binding]; other site
365044005303	Mg2+ binding site [ion binding]; other site
365044005304	G-X-G motif; other site
365044005305	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044005306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044005307	active site
365044005308	phosphorylation site [posttranslational modification]
365044005309	intermolecular recognition site; other site
365044005310	dimerization interface [polypeptide binding]; other site
365044005311	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044005312	DNA binding site [nucleotide binding]
365044005313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044005314	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
365044005315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
365044005316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044005317	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
365044005318	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
365044005319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044005320	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044005321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044005322	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
365044005323	classical (c) SDRs; Region: SDR_c; cd05233
365044005324	NAD(P) binding site [chemical binding]; other site
365044005325	active site
365044005326	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
365044005327	UbiA prenyltransferase family; Region: UbiA; pfam01040
365044005328	Hemerythrin; Region: Hemerythrin; cd12107
365044005329	Fe binding site [ion binding]; other site
365044005330	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
365044005331	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044005332	ATP binding site [chemical binding]; other site
365044005333	Mg++ binding site [ion binding]; other site
365044005334	motif III; other site
365044005335	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044005336	nucleotide binding region [chemical binding]; other site
365044005337	ATP-binding site [chemical binding]; other site
365044005338	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
365044005339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044005340	Walker A/P-loop; other site
365044005341	ATP binding site [chemical binding]; other site
365044005342	Q-loop/lid; other site
365044005343	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365044005344	ABC transporter signature motif; other site
365044005345	Walker B; other site
365044005346	D-loop; other site
365044005347	ABC transporter; Region: ABC_tran_2; pfam12848
365044005348	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365044005349	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
365044005350	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
365044005351	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
365044005352	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
365044005353	metal binding site [ion binding]; metal-binding site
365044005354	putative dimer interface [polypeptide binding]; other site
365044005355	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
365044005356	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
365044005357	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044005358	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
365044005359	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044005360	motif II; other site
365044005361	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365044005362	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
365044005363	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
365044005364	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
365044005365	Fe2+ transport protein; Region: Iron_transport; cl01377
365044005366	YHS domain; Region: YHS; pfam04945
365044005367	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
365044005368	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044005369	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044005370	motif II; other site
365044005371	Predicted metal-binding protein [General function prediction only]; Region: COG3019
365044005372	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
365044005373	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
365044005374	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
365044005375	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
365044005376	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
365044005377	Herpesvirus UL21; Region: Herpes_UL21; pfam03252
365044005378	Ion transport protein; Region: Ion_trans; pfam00520
365044005379	Ion channel; Region: Ion_trans_2; pfam07885
365044005380	Double zinc ribbon; Region: DZR; pfam12773
365044005381	YaeQ protein; Region: YaeQ; pfam07152
365044005382	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
365044005383	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044005384	FeS/SAM binding site; other site
365044005385	HemN C-terminal domain; Region: HemN_C; pfam06969
365044005386	Domain of unknown function (DUF427); Region: DUF427; pfam04248
365044005387	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044005388	Ligand Binding Site [chemical binding]; other site
365044005389	Protein of unknown function (DUF465); Region: DUF465; cl01070
365044005390	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
365044005391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005392	short chain dehydrogenase; Provisional; Region: PRK07023
365044005393	NAD(P) binding site [chemical binding]; other site
365044005394	active site
365044005395	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365044005396	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365044005397	active site
365044005398	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
365044005399	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044005400	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044005401	Probable transposase; Region: OrfB_IS605; pfam01385
365044005402	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044005403	Transposase IS200 like; Region: Y1_Tnp; pfam01797
365044005404	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
365044005405	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044005406	H+ Antiporter protein; Region: 2A0121; TIGR00900
365044005407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005408	putative substrate translocation pore; other site
365044005409	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044005410	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044005411	Cytochrome c; Region: Cytochrom_C; pfam00034
365044005412	Cytochrome c; Region: Cytochrom_C; cl11414
365044005413	Cytochrome c; Region: Cytochrom_C; cl11414
365044005414	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365044005415	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
365044005416	putative active site [active]
365044005417	Zn binding site [ion binding]; other site
365044005418	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044005419	catalytic loop [active]
365044005420	iron binding site [ion binding]; other site
365044005421	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365044005422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044005423	Coenzyme A binding pocket [chemical binding]; other site
365044005424	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
365044005425	Protein of unknown function (DUF808); Region: DUF808; pfam05661
365044005426	short chain dehydrogenase; Validated; Region: PRK08264
365044005427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005428	NAD(P) binding site [chemical binding]; other site
365044005429	active site
365044005430	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365044005431	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
365044005432	putative NAD(P) binding site [chemical binding]; other site
365044005433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044005435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044005436	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044005437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044005438	Probable transposase; Region: OrfB_IS605; pfam01385
365044005439	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044005440	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044005441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044005442	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
365044005443	putative effector binding pocket; other site
365044005444	putative dimerization interface [polypeptide binding]; other site
365044005445	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
365044005446	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044005447	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044005448	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
365044005449	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044005450	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
365044005451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044005452	S-adenosylmethionine binding site [chemical binding]; other site
365044005453	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
365044005454	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365044005455	FMN binding site [chemical binding]; other site
365044005456	active site
365044005457	catalytic residues [active]
365044005458	substrate binding site [chemical binding]; other site
365044005459	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
365044005460	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
365044005461	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
365044005462	heme-binding site [chemical binding]; other site
365044005463	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
365044005464	FAD binding pocket [chemical binding]; other site
365044005465	FAD binding motif [chemical binding]; other site
365044005466	phosphate binding motif [ion binding]; other site
365044005467	beta-alpha-beta structure motif; other site
365044005468	NAD binding pocket [chemical binding]; other site
365044005469	Heme binding  pocket [chemical binding]; other site
365044005470	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
365044005471	GAF domain; Region: GAF; pfam01590
365044005472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044005473	Walker A motif; other site
365044005474	ATP binding site [chemical binding]; other site
365044005475	Walker B motif; other site
365044005476	arginine finger; other site
365044005477	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
365044005478	putative hydrolase; Provisional; Region: PRK11460
365044005479	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
365044005480	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
365044005481	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
365044005482	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
365044005483	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
365044005484	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
365044005485	GTP/Mg2+ binding site [chemical binding]; other site
365044005486	G4 box; other site
365044005487	G5 box; other site
365044005488	G1 box; other site
365044005489	Switch I region; other site
365044005490	G2 box; other site
365044005491	G3 box; other site
365044005492	Switch II region; other site
365044005493	Hemerythrin-like domain; Region: Hr-like; cd12108
365044005494	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044005495	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044005496	ligand binding site [chemical binding]; other site
365044005497	flexible hinge region; other site
365044005498	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
365044005499	non-specific DNA interactions [nucleotide binding]; other site
365044005500	DNA binding site [nucleotide binding]
365044005501	sequence specific DNA binding site [nucleotide binding]; other site
365044005502	putative cAMP binding site [chemical binding]; other site
365044005503	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044005504	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
365044005505	ligand binding site [chemical binding]; other site
365044005506	flexible hinge region; other site
365044005507	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
365044005508	Bacterial Ig-like domain; Region: Big_5; pfam13205
365044005509	Bacterial Ig-like domain; Region: Big_5; pfam13205
365044005510	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
365044005511	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
365044005512	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044005513	ligand binding site [chemical binding]; other site
365044005514	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044005515	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
365044005516	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
365044005517	putative dimer interface [polypeptide binding]; other site
365044005518	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
365044005519	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
365044005520	putative dimer interface [polypeptide binding]; other site
365044005521	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
365044005522	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
365044005523	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
365044005524	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
365044005525	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
365044005526	Transcriptional regulator; Region: Rrf2; cl17282
365044005527	Rrf2 family protein; Region: rrf2_super; TIGR00738
365044005528	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
365044005529	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
365044005530	Binuclear center (active site) [active]
365044005531	K-pathway; other site
365044005532	Putative proton exit pathway; other site
365044005533	Putative water exit pathway; other site
365044005534	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
365044005535	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
365044005536	thioredoxin 2; Provisional; Region: PRK10996
365044005537	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044005538	catalytic residues [active]
365044005539	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
365044005540	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
365044005541	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044005542	pseudouridine synthase; Region: TIGR00093
365044005543	active site
365044005544	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
365044005545	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
365044005546	active site
365044005547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
365044005548	Isochorismatase family; Region: Isochorismatase; pfam00857
365044005549	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
365044005550	catalytic triad [active]
365044005551	dimer interface [polypeptide binding]; other site
365044005552	conserved cis-peptide bond; other site
365044005553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044005554	transcriptional activator TtdR; Provisional; Region: PRK09801
365044005555	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044005556	putative effector binding pocket; other site
365044005557	dimerization interface [polypeptide binding]; other site
365044005558	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
365044005559	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
365044005560	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044005561	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
365044005562	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044005563	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
365044005564	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365044005565	active site
365044005566	NTP binding site [chemical binding]; other site
365044005567	metal binding triad [ion binding]; metal-binding site
365044005568	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
365044005569	DNA-binding site [nucleotide binding]; DNA binding site
365044005570	RNA-binding motif; other site
365044005571	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
365044005572	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
365044005573	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365044005574	putative active site [active]
365044005575	putative NTP binding site [chemical binding]; other site
365044005576	putative nucleic acid binding site [nucleotide binding]; other site
365044005577	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
365044005578	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
365044005579	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
365044005580	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044005581	active site
365044005582	HIGH motif; other site
365044005583	nucleotide binding site [chemical binding]; other site
365044005584	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
365044005585	KMSKS motif; other site
365044005586	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
365044005587	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
365044005588	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044005589	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044005590	trimer interface [polypeptide binding]; other site
365044005591	eyelet of channel; other site
365044005592	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
365044005593	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
365044005594	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044005595	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
365044005596	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
365044005597	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
365044005598	MutS domain I; Region: MutS_I; pfam01624
365044005599	MutS domain II; Region: MutS_II; pfam05188
365044005600	MutS domain III; Region: MutS_III; pfam05192
365044005601	MutS domain V; Region: MutS_V; pfam00488
365044005602	Walker A/P-loop; other site
365044005603	ATP binding site [chemical binding]; other site
365044005604	Q-loop/lid; other site
365044005605	ABC transporter signature motif; other site
365044005606	Walker B; other site
365044005607	D-loop; other site
365044005608	H-loop/switch region; other site
365044005609	EamA-like transporter family; Region: EamA; pfam00892
365044005610	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044005611	EamA-like transporter family; Region: EamA; pfam00892
365044005612	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044005613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044005614	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044005615	putative effector binding pocket; other site
365044005616	dimerization interface [polypeptide binding]; other site
365044005617	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
365044005618	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
365044005619	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
365044005620	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044005621	putative acyl-acceptor binding pocket; other site
365044005622	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044005623	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
365044005624	Ligand binding site; other site
365044005625	Putative Catalytic site; other site
365044005626	DXD motif; other site
365044005627	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044005628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005629	NAD(P) binding site [chemical binding]; other site
365044005630	active site
365044005631	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
365044005632	putative active site 1 [active]
365044005633	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
365044005634	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
365044005635	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365044005636	dimer interface [polypeptide binding]; other site
365044005637	active site
365044005638	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
365044005639	active site
365044005640	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
365044005641	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
365044005642	NodB motif; other site
365044005643	active site
365044005644	catalytic site [active]
365044005645	metal binding site [ion binding]; metal-binding site
365044005646	Predicted exporter [General function prediction only]; Region: COG4258
365044005647	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
365044005648	putative acyl-acceptor binding pocket; other site
365044005649	Predicted membrane protein [Function unknown]; Region: COG4648
365044005650	Phosphopantetheine attachment site; Region: PP-binding; cl09936
365044005651	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
365044005652	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
365044005653	active site
365044005654	dimerization interface [polypeptide binding]; other site
365044005655	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
365044005656	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
365044005657	serine O-acetyltransferase; Region: cysE; TIGR01172
365044005658	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365044005659	trimer interface [polypeptide binding]; other site
365044005660	active site
365044005661	substrate binding site [chemical binding]; other site
365044005662	CoA binding site [chemical binding]; other site
365044005663	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
365044005664	MPT binding site; other site
365044005665	trimer interface [polypeptide binding]; other site
365044005666	Protein of unknown function (DUF615); Region: DUF615; pfam04751
365044005667	peptidase PmbA; Provisional; Region: PRK11040
365044005668	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
365044005669	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
365044005670	Yqey-like protein; Region: YqeY; pfam09424
365044005671	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
365044005672	Predicted flavoproteins [General function prediction only]; Region: COG2081
365044005673	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
365044005674	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
365044005675	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
365044005676	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044005677	Winged helix-turn helix; Region: HTH_29; pfam13551
365044005678	Winged helix-turn helix; Region: HTH_33; pfam13592
365044005679	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044005680	Transposase domain (DUF772); Region: DUF772; pfam05598
365044005681	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
365044005682	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044005683	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044005684	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044005685	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044005686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044005687	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044005688	Predicted transcriptional regulator [Transcription]; Region: COG2378
365044005689	WYL domain; Region: WYL; pfam13280
365044005690	Predicted flavoproteins [General function prediction only]; Region: COG2081
365044005691	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
365044005692	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044005693	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
365044005694	active site
365044005695	SAM binding site [chemical binding]; other site
365044005696	homodimer interface [polypeptide binding]; other site
365044005697	glycosyl transferase family protein; Provisional; Region: PRK08136
365044005698	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
365044005699	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
365044005700	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
365044005701	[4Fe-4S] binding site [ion binding]; other site
365044005702	molybdopterin cofactor binding site; other site
365044005703	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
365044005704	molybdopterin cofactor binding site; other site
365044005705	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
365044005706	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
365044005707	[2Fe-2S] cluster binding site [ion binding]; other site
365044005708	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044005709	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044005710	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
365044005711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044005712	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044005713	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
365044005714	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
365044005715	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
365044005716	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
365044005717	FOG: CBS domain [General function prediction only]; Region: COG0517
365044005718	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044005719	Protein phosphatase 2C; Region: PP2C; pfam00481
365044005720	active site
365044005721	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
365044005722	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044005723	active site
365044005724	ATP binding site [chemical binding]; other site
365044005725	substrate binding site [chemical binding]; other site
365044005726	activation loop (A-loop); other site
365044005727	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
365044005728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005729	putative substrate translocation pore; other site
365044005730	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044005731	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
365044005732	Walker A/P-loop; other site
365044005733	ATP binding site [chemical binding]; other site
365044005734	Q-loop/lid; other site
365044005735	ABC transporter signature motif; other site
365044005736	Walker B; other site
365044005737	D-loop; other site
365044005738	H-loop/switch region; other site
365044005739	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044005740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005741	dimer interface [polypeptide binding]; other site
365044005742	conserved gate region; other site
365044005743	putative PBP binding loops; other site
365044005744	ABC-ATPase subunit interface; other site
365044005745	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
365044005746	NMT1-like family; Region: NMT1_2; pfam13379
365044005747	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
365044005748	ANTAR domain; Region: ANTAR; pfam03861
365044005749	UGMP family protein; Validated; Region: PRK09604
365044005750	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
365044005751	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
365044005752	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044005753	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
365044005754	putative ligand binding site [chemical binding]; other site
365044005755	aspartate aminotransferase; Provisional; Region: PRK06108
365044005756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044005757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044005758	homodimer interface [polypeptide binding]; other site
365044005759	catalytic residue [active]
365044005760	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
365044005761	16S/18S rRNA binding site [nucleotide binding]; other site
365044005762	S13e-L30e interaction site [polypeptide binding]; other site
365044005763	25S rRNA binding site [nucleotide binding]; other site
365044005764	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
365044005765	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
365044005766	RNase E interface [polypeptide binding]; other site
365044005767	trimer interface [polypeptide binding]; other site
365044005768	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
365044005769	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
365044005770	RNase E interface [polypeptide binding]; other site
365044005771	trimer interface [polypeptide binding]; other site
365044005772	active site
365044005773	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
365044005774	putative nucleic acid binding region [nucleotide binding]; other site
365044005775	G-X-X-G motif; other site
365044005776	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
365044005777	RNA binding site [nucleotide binding]; other site
365044005778	domain interface; other site
365044005779	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
365044005780	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
365044005781	NAD(P) binding site [chemical binding]; other site
365044005782	triosephosphate isomerase; Provisional; Region: PRK14567
365044005783	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
365044005784	dimer interface [polypeptide binding]; other site
365044005785	substrate binding site [chemical binding]; other site
365044005786	catalytic triad [active]
365044005787	Preprotein translocase SecG subunit; Region: SecG; pfam03840
365044005788	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
365044005789	NADH dehydrogenase subunit B; Validated; Region: PRK06411
365044005790	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
365044005791	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
365044005792	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
365044005793	NADH dehydrogenase subunit D; Validated; Region: PRK06075
365044005794	NADH dehydrogenase subunit E; Validated; Region: PRK07539
365044005795	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
365044005796	putative dimer interface [polypeptide binding]; other site
365044005797	[2Fe-2S] cluster binding site [ion binding]; other site
365044005798	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
365044005799	SLBB domain; Region: SLBB; pfam10531
365044005800	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
365044005801	NADH dehydrogenase subunit G; Validated; Region: PRK09129
365044005802	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044005803	catalytic loop [active]
365044005804	iron binding site [ion binding]; other site
365044005805	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
365044005806	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
365044005807	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
365044005808	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
365044005809	4Fe-4S binding domain; Region: Fer4; pfam00037
365044005810	4Fe-4S binding domain; Region: Fer4; pfam00037
365044005811	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
365044005812	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
365044005813	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
365044005814	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
365044005815	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
365044005816	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
365044005817	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
365044005818	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
365044005819	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
365044005820	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
365044005821	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
365044005822	dimer interface [polypeptide binding]; other site
365044005823	ADP-ribose binding site [chemical binding]; other site
365044005824	active site
365044005825	nudix motif; other site
365044005826	metal binding site [ion binding]; metal-binding site
365044005827	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
365044005828	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
365044005829	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
365044005830	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
365044005831	NAD(P) binding site [chemical binding]; other site
365044005832	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
365044005833	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365044005834	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
365044005835	Walker A/P-loop; other site
365044005836	ATP binding site [chemical binding]; other site
365044005837	Q-loop/lid; other site
365044005838	ABC transporter signature motif; other site
365044005839	Walker B; other site
365044005840	D-loop; other site
365044005841	H-loop/switch region; other site
365044005842	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044005843	MarR family; Region: MarR; pfam01047
365044005844	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044005845	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
365044005846	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044005847	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044005848	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
365044005849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005850	putative substrate translocation pore; other site
365044005851	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
365044005852	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
365044005853	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
365044005854	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365044005855	DNA binding residues [nucleotide binding]
365044005856	B12 binding domain; Region: B12-binding_2; pfam02607
365044005857	B12 binding domain; Region: B12-binding; pfam02310
365044005858	B12 binding site [chemical binding]; other site
365044005859	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
365044005860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044005861	hydroxyglutarate oxidase; Provisional; Region: PRK11728
365044005862	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
365044005863	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
365044005864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044005865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044005866	S-adenosylmethionine binding site [chemical binding]; other site
365044005867	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
365044005868	MFS/sugar transport protein; Region: MFS_2; pfam13347
365044005869	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
365044005870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005871	short chain dehydrogenase; Provisional; Region: PRK06101
365044005872	NAD(P) binding site [chemical binding]; other site
365044005873	active site
365044005874	SnoaL-like domain; Region: SnoaL_2; pfam12680
365044005875	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
365044005876	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
365044005877	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
365044005878	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365044005879	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
365044005880	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
365044005881	RimM N-terminal domain; Region: RimM; pfam01782
365044005882	PRC-barrel domain; Region: PRC; pfam05239
365044005883	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
365044005884	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
365044005885	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
365044005886	putative active site [active]
365044005887	putative CoA binding site [chemical binding]; other site
365044005888	nudix motif; other site
365044005889	metal binding site [ion binding]; metal-binding site
365044005890	CobD/Cbib protein; Region: CobD_Cbib; cl00561
365044005891	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
365044005892	GTPase RsgA; Reviewed; Region: PRK00098
365044005893	RNA binding site [nucleotide binding]; other site
365044005894	homodimer interface [polypeptide binding]; other site
365044005895	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
365044005896	GTPase/Zn-binding domain interface [polypeptide binding]; other site
365044005897	GTP/Mg2+ binding site [chemical binding]; other site
365044005898	G4 box; other site
365044005899	G5 box; other site
365044005900	G1 box; other site
365044005901	Switch I region; other site
365044005902	G2 box; other site
365044005903	G3 box; other site
365044005904	Switch II region; other site
365044005905	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
365044005906	aromatic arch; other site
365044005907	DCoH dimer interaction site [polypeptide binding]; other site
365044005908	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
365044005909	DCoH tetramer interaction site [polypeptide binding]; other site
365044005910	substrate binding site [chemical binding]; other site
365044005911	Peptidase family M48; Region: Peptidase_M48; pfam01435
365044005912	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
365044005913	catalytic site [active]
365044005914	putative active site [active]
365044005915	putative substrate binding site [chemical binding]; other site
365044005916	dimer interface [polypeptide binding]; other site
365044005917	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044005918	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044005919	ATP binding site [chemical binding]; other site
365044005920	Mg++ binding site [ion binding]; other site
365044005921	motif III; other site
365044005922	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044005923	nucleotide binding region [chemical binding]; other site
365044005924	ATP-binding site [chemical binding]; other site
365044005925	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
365044005926	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
365044005927	active site
365044005928	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
365044005929	Part of AAA domain; Region: AAA_19; pfam13245
365044005930	Family description; Region: UvrD_C_2; pfam13538
365044005931	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
365044005932	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
365044005933	putative active site [active]
365044005934	putative substrate binding site [chemical binding]; other site
365044005935	ATP binding site [chemical binding]; other site
365044005936	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
365044005937	DNA polymerase I; Provisional; Region: PRK05755
365044005938	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
365044005939	active site
365044005940	metal binding site 1 [ion binding]; metal-binding site
365044005941	putative 5' ssDNA interaction site; other site
365044005942	metal binding site 3; metal-binding site
365044005943	metal binding site 2 [ion binding]; metal-binding site
365044005944	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
365044005945	putative DNA binding site [nucleotide binding]; other site
365044005946	putative metal binding site [ion binding]; other site
365044005947	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
365044005948	active site
365044005949	catalytic site [active]
365044005950	substrate binding site [chemical binding]; other site
365044005951	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
365044005952	active site
365044005953	DNA binding site [nucleotide binding]
365044005954	catalytic site [active]
365044005955	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
365044005956	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
365044005957	NADH(P)-binding; Region: NAD_binding_10; pfam13460
365044005958	putative NAD(P) binding site [chemical binding]; other site
365044005959	active site
365044005960	Protein of unknown function, DUF393; Region: DUF393; pfam04134
365044005961	Predicted transcriptional regulators [Transcription]; Region: COG1510
365044005962	MarR family; Region: MarR_2; pfam12802
365044005963	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
365044005964	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
365044005965	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
365044005966	dimerization interface [polypeptide binding]; other site
365044005967	ligand binding site [chemical binding]; other site
365044005968	NADP binding site [chemical binding]; other site
365044005969	catalytic site [active]
365044005970	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044005971	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
365044005972	substrate binding site [chemical binding]; other site
365044005973	ATP binding site [chemical binding]; other site
365044005974	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
365044005975	Glycine reductase complex selenoprotein A; Region: GRDA; cl04705
365044005976	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044005977	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365044005978	Walker A/P-loop; other site
365044005979	ATP binding site [chemical binding]; other site
365044005980	Q-loop/lid; other site
365044005981	ABC transporter signature motif; other site
365044005982	Walker B; other site
365044005983	D-loop; other site
365044005984	H-loop/switch region; other site
365044005985	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044005986	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044005987	substrate binding pocket [chemical binding]; other site
365044005988	membrane-bound complex binding site; other site
365044005989	hinge residues; other site
365044005990	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044005991	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005992	dimer interface [polypeptide binding]; other site
365044005993	conserved gate region; other site
365044005994	putative PBP binding loops; other site
365044005995	ABC-ATPase subunit interface; other site
365044005996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005997	dimer interface [polypeptide binding]; other site
365044005998	conserved gate region; other site
365044005999	ABC-ATPase subunit interface; other site
365044006000	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044006001	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044006002	DNA binding site [nucleotide binding]
365044006003	domain linker motif; other site
365044006004	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
365044006005	putative dimerization interface [polypeptide binding]; other site
365044006006	putative ligand binding site [chemical binding]; other site
365044006007	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
365044006008	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
365044006009	active site residue [active]
365044006010	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
365044006011	active site residue [active]
365044006012	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044006013	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
365044006014	[2Fe-2S] cluster binding site [ion binding]; other site
365044006015	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
365044006016	alpha subunit interface [polypeptide binding]; other site
365044006017	active site
365044006018	substrate binding site [chemical binding]; other site
365044006019	Fe binding site [ion binding]; other site
365044006020	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
365044006021	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
365044006022	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
365044006023	substrate binding pocket [chemical binding]; other site
365044006024	chain length determination region; other site
365044006025	substrate-Mg2+ binding site; other site
365044006026	catalytic residues [active]
365044006027	aspartate-rich region 1; other site
365044006028	active site lid residues [active]
365044006029	aspartate-rich region 2; other site
365044006030	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
365044006031	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
365044006032	TPP-binding site; other site
365044006033	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044006034	PYR/PP interface [polypeptide binding]; other site
365044006035	dimer interface [polypeptide binding]; other site
365044006036	TPP binding site [chemical binding]; other site
365044006037	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044006038	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
365044006039	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044006040	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
365044006041	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
365044006042	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
365044006043	selenophosphate synthetase; Provisional; Region: PRK00943
365044006044	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
365044006045	dimerization interface [polypeptide binding]; other site
365044006046	putative ATP binding site [chemical binding]; other site
365044006047	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
365044006048	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
365044006049	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
365044006050	PBP superfamily domain; Region: PBP_like; pfam12727
365044006051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044006052	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044006053	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
365044006054	Walker A/P-loop; other site
365044006055	ATP binding site [chemical binding]; other site
365044006056	Q-loop/lid; other site
365044006057	ABC transporter signature motif; other site
365044006058	Walker B; other site
365044006059	D-loop; other site
365044006060	H-loop/switch region; other site
365044006061	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
365044006062	PBP superfamily domain; Region: PBP_like_2; pfam12849
365044006063	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
365044006064	Protein of unknown function (DUF461); Region: DUF461; pfam04314
365044006065	Hemerythrin-like domain; Region: Hr-like; cd12108
365044006066	chromosome condensation membrane protein; Provisional; Region: PRK14196
365044006067	5-oxoprolinase; Region: PLN02666
365044006068	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044006069	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
365044006070	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
365044006071	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
365044006072	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
365044006073	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
365044006074	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
365044006075	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
365044006076	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
365044006077	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
365044006078	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
365044006079	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
365044006080	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
365044006081	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
365044006082	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
365044006083	chaperone protein DnaJ; Provisional; Region: PRK10767
365044006084	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044006085	HSP70 interaction site [polypeptide binding]; other site
365044006086	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
365044006087	Zn binding sites [ion binding]; other site
365044006088	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
365044006089	dimer interface [polypeptide binding]; other site
365044006090	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
365044006091	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
365044006092	nucleotide binding site [chemical binding]; other site
365044006093	GrpE; Region: GrpE; pfam01025
365044006094	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
365044006095	dimer interface [polypeptide binding]; other site
365044006096	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
365044006097	Predicted transcriptional regulators [Transcription]; Region: COG1733
365044006098	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
365044006099	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
365044006100	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
365044006101	pentamer interface [polypeptide binding]; other site
365044006102	dodecaamer interface [polypeptide binding]; other site
365044006103	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365044006104	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
365044006105	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
365044006106	Dihaem cytochrome c; Region: DHC; pfam09626
365044006107	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044006108	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
365044006109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006110	active site
365044006111	phosphorylation site [posttranslational modification]
365044006112	intermolecular recognition site; other site
365044006113	dimerization interface [polypeptide binding]; other site
365044006114	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044006115	DNA binding site [nucleotide binding]
365044006116	sensor protein QseC; Provisional; Region: PRK10337
365044006117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044006118	dimer interface [polypeptide binding]; other site
365044006119	phosphorylation site [posttranslational modification]
365044006120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006121	ATP binding site [chemical binding]; other site
365044006122	Mg2+ binding site [ion binding]; other site
365044006123	G-X-G motif; other site
365044006124	CCC1-related family of proteins; Region: CCC1_like; cl00278
365044006125	CCC1-related family of proteins; Region: CCC1_like; cl00278
365044006126	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365044006127	FMN binding site [chemical binding]; other site
365044006128	substrate binding site [chemical binding]; other site
365044006129	putative catalytic residue [active]
365044006130	Predicted flavoprotein [General function prediction only]; Region: COG0431
365044006131	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044006132	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
365044006133	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044006134	LysR family transcriptional regulator; Provisional; Region: PRK14997
365044006135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044006136	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
365044006137	putative effector binding pocket; other site
365044006138	putative dimerization interface [polypeptide binding]; other site
365044006139	Serine hydrolase; Region: Ser_hydrolase; pfam06821
365044006140	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044006141	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
365044006142	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044006143	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
365044006144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044006145	dimer interface [polypeptide binding]; other site
365044006146	conserved gate region; other site
365044006147	putative PBP binding loops; other site
365044006148	ABC-ATPase subunit interface; other site
365044006149	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
365044006150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044006151	dimer interface [polypeptide binding]; other site
365044006152	conserved gate region; other site
365044006153	putative PBP binding loops; other site
365044006154	ABC-ATPase subunit interface; other site
365044006155	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
365044006156	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
365044006157	Walker A/P-loop; other site
365044006158	ATP binding site [chemical binding]; other site
365044006159	Q-loop/lid; other site
365044006160	ABC transporter signature motif; other site
365044006161	Walker B; other site
365044006162	D-loop; other site
365044006163	H-loop/switch region; other site
365044006164	TOBE-like domain; Region: TOBE_3; pfam12857
365044006165	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
365044006166	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
365044006167	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044006168	active site
365044006169	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044006170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044006171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044006172	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
365044006173	substrate binding pocket [chemical binding]; other site
365044006174	dimerization interface [polypeptide binding]; other site
365044006175	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044006176	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
365044006177	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044006178	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044006179	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044006180	active site
365044006181	metal binding site [ion binding]; metal-binding site
365044006182	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
365044006183	active site
365044006184	catalytic site [active]
365044006185	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044006186	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044006187	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
365044006188	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044006189	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044006190	shikimate binding site; other site
365044006191	NAD(P) binding site [chemical binding]; other site
365044006192	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
365044006193	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
365044006194	DctM-like transporters; Region: DctM; pfam06808
365044006195	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044006196	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044006197	Dehydroquinase class II; Region: DHquinase_II; pfam01220
365044006198	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
365044006199	trimer interface [polypeptide binding]; other site
365044006200	active site
365044006201	dimer interface [polypeptide binding]; other site
365044006202	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
365044006203	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
365044006204	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
365044006205	dimer interface [polypeptide binding]; other site
365044006206	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
365044006207	active site
365044006208	Fe binding site [ion binding]; other site
365044006209	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
365044006210	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044006211	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044006212	shikimate binding site; other site
365044006213	NAD(P) binding site [chemical binding]; other site
365044006214	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
365044006215	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044006216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044006217	homodimer interface [polypeptide binding]; other site
365044006218	catalytic residue [active]
365044006219	excinuclease ABC subunit B; Provisional; Region: PRK05298
365044006220	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044006221	ATP binding site [chemical binding]; other site
365044006222	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044006223	nucleotide binding region [chemical binding]; other site
365044006224	ATP-binding site [chemical binding]; other site
365044006225	Ultra-violet resistance protein B; Region: UvrB; pfam12344
365044006226	UvrB/uvrC motif; Region: UVR; pfam02151
365044006227	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
365044006228	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044006229	catalytic loop [active]
365044006230	iron binding site [ion binding]; other site
365044006231	chaperone protein HscA; Provisional; Region: hscA; PRK05183
365044006232	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
365044006233	nucleotide binding site [chemical binding]; other site
365044006234	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365044006235	SBD interface [polypeptide binding]; other site
365044006236	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044006237	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
365044006238	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
365044006239	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
365044006240	trimerization site [polypeptide binding]; other site
365044006241	active site
365044006242	cysteine desulfurase; Provisional; Region: PRK14012
365044006243	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
365044006244	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044006245	catalytic residue [active]
365044006246	Nif-specific regulatory protein; Region: nifA; TIGR01817
365044006247	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
365044006248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044006249	Walker A motif; other site
365044006250	ATP binding site [chemical binding]; other site
365044006251	Walker B motif; other site
365044006252	arginine finger; other site
365044006253	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044006254	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044006255	Coenzyme A binding pocket [chemical binding]; other site
365044006256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
365044006257	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
365044006258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044006259	FeS/SAM binding site; other site
365044006260	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
365044006261	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044006262	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
365044006263	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
365044006264	NifZ domain; Region: NifZ; pfam04319
365044006265	NifZ domain; Region: NifZ; pfam04319
365044006266	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
365044006267	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044006268	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
365044006269	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044006270	catalytic residue [active]
365044006271	NifT/FixU protein; Region: NifT; pfam06988
365044006272	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
365044006273	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365044006274	inhibitor-cofactor binding pocket; inhibition site
365044006275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044006276	catalytic residue [active]
365044006277	SIR2-like domain; Region: SIR2_2; pfam13289
365044006278	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
365044006279	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044006280	catalytic loop [active]
365044006281	iron binding site [ion binding]; other site
365044006282	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044006283	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
365044006284	Uncharacterized conserved protein [Function unknown]; Region: COG0397
365044006285	hypothetical protein; Validated; Region: PRK00029
365044006286	Transcriptional regulators [Transcription]; Region: FadR; COG2186
365044006287	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044006288	DNA-binding site [nucleotide binding]; DNA binding site
365044006289	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
365044006290	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044006291	extended (e) SDRs; Region: SDR_e; cd08946
365044006292	NAD(P) binding site [chemical binding]; other site
365044006293	active site
365044006294	substrate binding site [chemical binding]; other site
365044006295	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
365044006296	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044006297	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044006298	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
365044006299	DctM-like transporters; Region: DctM; pfam06808
365044006300	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
365044006301	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
365044006302	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365044006303	putative active site [active]
365044006304	catalytic residue [active]
365044006305	galactarate dehydratase; Region: galactar-dH20; TIGR03248
365044006306	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
365044006307	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
365044006308	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
365044006309	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044006310	NAD(P) binding site [chemical binding]; other site
365044006311	catalytic residues [active]
365044006312	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
365044006313	tartronate semialdehyde reductase; Provisional; Region: PRK15059
365044006314	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
365044006315	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044006316	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044006317	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044006318	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
365044006319	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
365044006320	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
365044006321	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
365044006322	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
365044006323	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044006324	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
365044006325	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044006326	DNA binding residues [nucleotide binding]
365044006327	DNA primase, catalytic core; Region: dnaG; TIGR01391
365044006328	CHC2 zinc finger; Region: zf-CHC2; pfam01807
365044006329	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
365044006330	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
365044006331	active site
365044006332	metal binding site [ion binding]; metal-binding site
365044006333	interdomain interaction site; other site
365044006334	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
365044006335	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
365044006336	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
365044006337	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
365044006338	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
365044006339	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
365044006340	NAD binding site [chemical binding]; other site
365044006341	homodimer interface [polypeptide binding]; other site
365044006342	homotetramer interface [polypeptide binding]; other site
365044006343	active site
365044006344	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
365044006345	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
365044006346	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
365044006347	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
365044006348	nucleophile elbow; other site
365044006349	Phasin protein; Region: Phasin_2; pfam09361
365044006350	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
365044006351	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
365044006352	putative active site [active]
365044006353	Zn binding site [ion binding]; other site
365044006354	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044006355	active site
365044006356	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
365044006357	putative FMN binding site [chemical binding]; other site
365044006358	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044006359	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044006360	TM-ABC transporter signature motif; other site
365044006361	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044006362	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044006363	TM-ABC transporter signature motif; other site
365044006364	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044006365	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044006366	Walker A/P-loop; other site
365044006367	ATP binding site [chemical binding]; other site
365044006368	Q-loop/lid; other site
365044006369	ABC transporter signature motif; other site
365044006370	Walker B; other site
365044006371	D-loop; other site
365044006372	H-loop/switch region; other site
365044006373	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044006374	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044006375	Walker A/P-loop; other site
365044006376	ATP binding site [chemical binding]; other site
365044006377	Q-loop/lid; other site
365044006378	ABC transporter signature motif; other site
365044006379	Walker B; other site
365044006380	D-loop; other site
365044006381	H-loop/switch region; other site
365044006382	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
365044006383	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
365044006384	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
365044006385	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
365044006386	active site
365044006387	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
365044006388	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
365044006389	transmembrane helices; other site
365044006390	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
365044006391	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
365044006392	dimerization interface [polypeptide binding]; other site
365044006393	ligand binding site [chemical binding]; other site
365044006394	NADP binding site [chemical binding]; other site
365044006395	catalytic site [active]
365044006396	RmuC family; Region: RmuC; pfam02646
365044006397	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
365044006398	elongation factor P; Validated; Region: PRK00529
365044006399	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
365044006400	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
365044006401	RNA binding site [nucleotide binding]; other site
365044006402	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
365044006403	RNA binding site [nucleotide binding]; other site
365044006404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
365044006405	conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837
365044006406	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
365044006407	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
365044006408	GIY-YIG motif/motif A; other site
365044006409	active site
365044006410	catalytic site [active]
365044006411	putative DNA binding site [nucleotide binding]; other site
365044006412	metal binding site [ion binding]; metal-binding site
365044006413	UvrB/uvrC motif; Region: UVR; pfam02151
365044006414	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
365044006415	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
365044006416	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
365044006417	transcriptional activator TtdR; Provisional; Region: PRK09801
365044006418	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044006419	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
365044006420	putative effector binding pocket; other site
365044006421	putative dimerization interface [polypeptide binding]; other site
365044006422	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365044006423	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
365044006424	tartrate dehydrogenase; Region: TTC; TIGR02089
365044006425	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365044006426	IHF dimer interface [polypeptide binding]; other site
365044006427	IHF - DNA interface [nucleotide binding]; other site
365044006428	SurA N-terminal domain; Region: SurA_N_3; cl07813
365044006429	periplasmic folding chaperone; Provisional; Region: PRK10788
365044006430	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
365044006431	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
365044006432	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
365044006433	elongation factor G; Reviewed; Region: PRK00007
365044006434	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
365044006435	G1 box; other site
365044006436	putative GEF interaction site [polypeptide binding]; other site
365044006437	GTP/Mg2+ binding site [chemical binding]; other site
365044006438	Switch I region; other site
365044006439	G2 box; other site
365044006440	G3 box; other site
365044006441	Switch II region; other site
365044006442	G4 box; other site
365044006443	G5 box; other site
365044006444	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
365044006445	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
365044006446	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
365044006447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006448	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006449	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006450	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
365044006451	Predicted membrane protein [Function unknown]; Region: COG4267
365044006452	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
365044006453	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044006454	GAF domain; Region: GAF_3; pfam13492
365044006455	Tetratricopeptide repeat; Region: TPR_15; pfam13429
365044006456	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
365044006457	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
365044006458	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
365044006459	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044006460	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
365044006461	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044006462	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044006463	shikimate binding site; other site
365044006464	NAD(P) binding site [chemical binding]; other site
365044006465	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044006466	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
365044006467	ligand binding site [chemical binding]; other site
365044006468	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044006469	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044006470	TM-ABC transporter signature motif; other site
365044006471	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044006472	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044006473	TM-ABC transporter signature motif; other site
365044006474	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044006475	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044006476	Walker A/P-loop; other site
365044006477	ATP binding site [chemical binding]; other site
365044006478	Q-loop/lid; other site
365044006479	ABC transporter signature motif; other site
365044006480	Walker B; other site
365044006481	D-loop; other site
365044006482	H-loop/switch region; other site
365044006483	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044006484	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044006485	Walker A/P-loop; other site
365044006486	ATP binding site [chemical binding]; other site
365044006487	Q-loop/lid; other site
365044006488	ABC transporter signature motif; other site
365044006489	Walker B; other site
365044006490	D-loop; other site
365044006491	H-loop/switch region; other site
365044006492	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
365044006493	dimer interface [polypeptide binding]; other site
365044006494	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044006495	active site
365044006496	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
365044006497	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
365044006498	Lyase; Region: Lyase_1; pfam00206
365044006499	tetramer interface [polypeptide binding]; other site
365044006500	active site
365044006501	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365044006502	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044006503	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
365044006504	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044006505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044006506	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
365044006507	putative substrate binding pocket [chemical binding]; other site
365044006508	putative dimerization interface [polypeptide binding]; other site
365044006509	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
365044006510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044006511	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
365044006512	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
365044006513	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044006514	active site
365044006515	metal binding site [ion binding]; metal-binding site
365044006516	DNA binding site [nucleotide binding]
365044006517	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044006518	Walker A/P-loop; other site
365044006519	ATP binding site [chemical binding]; other site
365044006520	Cytochrome c; Region: Cytochrom_C; cl11414
365044006521	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
365044006522	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
365044006523	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
365044006524	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
365044006525	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
365044006526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044006527	Walker A motif; other site
365044006528	ATP binding site [chemical binding]; other site
365044006529	Walker B motif; other site
365044006530	arginine finger; other site
365044006531	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
365044006532	hypothetical protein; Validated; Region: PRK00153
365044006533	recombination protein RecR; Reviewed; Region: recR; PRK00076
365044006534	RecR protein; Region: RecR; pfam02132
365044006535	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
365044006536	putative active site [active]
365044006537	putative metal-binding site [ion binding]; other site
365044006538	tetramer interface [polypeptide binding]; other site
365044006539	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
365044006540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
365044006541	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044006542	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
365044006543	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044006544	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044006545	catalytic residue [active]
365044006546	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044006547	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
365044006548	Methyltransferase domain; Region: Methyltransf_11; pfam08241
365044006549	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
365044006550	RNA/DNA hybrid binding site [nucleotide binding]; other site
365044006551	active site
365044006552	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044006553	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044006554	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044006555	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044006556	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
365044006557	active site
365044006558	catalytic triad [active]
365044006559	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
365044006560	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044006561	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044006562	DNA binding residues [nucleotide binding]
365044006563	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
365044006564	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
365044006565	dimer interface [polypeptide binding]; other site
365044006566	putative functional site; other site
365044006567	putative MPT binding site; other site
365044006568	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
365044006569	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
365044006570	GTP binding site; other site
365044006571	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
365044006572	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044006573	FeS/SAM binding site; other site
365044006574	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
365044006575	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044006576	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044006577	putative ligand binding site [chemical binding]; other site
365044006578	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044006579	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
365044006580	NAD(P) binding site [chemical binding]; other site
365044006581	catalytic residues [active]
365044006582	catalytic residues [active]
365044006583	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
365044006584	Response regulator receiver domain; Region: Response_reg; pfam00072
365044006585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006586	active site
365044006587	phosphorylation site [posttranslational modification]
365044006588	intermolecular recognition site; other site
365044006589	dimerization interface [polypeptide binding]; other site
365044006590	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044006591	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044006592	putative binding surface; other site
365044006593	active site
365044006594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006595	ATP binding site [chemical binding]; other site
365044006596	Mg2+ binding site [ion binding]; other site
365044006597	G-X-G motif; other site
365044006598	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
365044006599	XAP5, circadian clock regulator; Region: XAP5; pfam04921
365044006600	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044006601	hypothetical protein; Validated; Region: PRK08245
365044006602	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
365044006603	RRXRR protein; Region: RRXRR; pfam14239
365044006604	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044006605	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044006606	active site
365044006607	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044006608	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044006609	DNA-binding site [nucleotide binding]; DNA binding site
365044006610	FCD domain; Region: FCD; pfam07729
365044006611	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
365044006612	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
365044006613	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
365044006614	dimer interface [polypeptide binding]; other site
365044006615	substrate binding site [chemical binding]; other site
365044006616	metal binding sites [ion binding]; metal-binding site
365044006617	CheB methylesterase; Region: CheB_methylest; pfam01339
365044006618	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
365044006619	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
365044006620	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
365044006621	PAS domain; Region: PAS_10; pfam13596
365044006622	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044006623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044006624	putative active site [active]
365044006625	heme pocket [chemical binding]; other site
365044006626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044006627	dimer interface [polypeptide binding]; other site
365044006628	phosphorylation site [posttranslational modification]
365044006629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006630	ATP binding site [chemical binding]; other site
365044006631	Mg2+ binding site [ion binding]; other site
365044006632	G-X-G motif; other site
365044006633	Response regulator receiver domain; Region: Response_reg; pfam00072
365044006634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006635	active site
365044006636	phosphorylation site [posttranslational modification]
365044006637	intermolecular recognition site; other site
365044006638	dimerization interface [polypeptide binding]; other site
365044006639	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044006640	PGAP1-like protein; Region: PGAP1; pfam07819
365044006641	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
365044006642	Protein of unknown function, DUF482; Region: DUF482; pfam04339
365044006643	NAD synthetase; Provisional; Region: PRK13981
365044006644	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
365044006645	multimer interface [polypeptide binding]; other site
365044006646	active site
365044006647	catalytic triad [active]
365044006648	protein interface 1 [polypeptide binding]; other site
365044006649	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
365044006650	homodimer interface [polypeptide binding]; other site
365044006651	NAD binding pocket [chemical binding]; other site
365044006652	ATP binding pocket [chemical binding]; other site
365044006653	Mg binding site [ion binding]; other site
365044006654	active-site loop [active]
365044006655	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
365044006656	Nitrogen regulatory protein P-II; Region: P-II; smart00938
365044006657	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
365044006658	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
365044006659	RDD family; Region: RDD; pfam06271
365044006660	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
365044006661	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
365044006662	RNA polymerase factor sigma-70; Validated; Region: PRK09047
365044006663	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044006664	DNA binding residues [nucleotide binding]
365044006665	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
365044006666	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365044006667	PYR/PP interface [polypeptide binding]; other site
365044006668	dimer interface [polypeptide binding]; other site
365044006669	TPP binding site [chemical binding]; other site
365044006670	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
365044006671	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
365044006672	TPP-binding site [chemical binding]; other site
365044006673	dimer interface [polypeptide binding]; other site
365044006674	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
365044006675	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
365044006676	putative valine binding site [chemical binding]; other site
365044006677	dimer interface [polypeptide binding]; other site
365044006678	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
365044006679	ketol-acid reductoisomerase; Provisional; Region: PRK05479
365044006680	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
365044006681	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
365044006682	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
365044006683	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
365044006684	2-isopropylmalate synthase; Validated; Region: PRK00915
365044006685	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
365044006686	active site
365044006687	catalytic residues [active]
365044006688	metal binding site [ion binding]; metal-binding site
365044006689	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
365044006690	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
365044006691	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
365044006692	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
365044006693	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044006694	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044006695	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
365044006696	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
365044006697	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
365044006698	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
365044006699	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044006700	active site
365044006701	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
365044006702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
365044006703	Walker A motif; other site
365044006704	ATP binding site [chemical binding]; other site
365044006705	hypothetical protein; Validated; Region: PRK00110
365044006706	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
365044006707	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
365044006708	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
365044006709	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
365044006710	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
365044006711	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
365044006712	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
365044006713	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
365044006714	Maf-like protein; Region: Maf; pfam02545
365044006715	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
365044006716	active site
365044006717	dimer interface [polypeptide binding]; other site
365044006718	ribonuclease G; Provisional; Region: PRK11712
365044006719	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
365044006720	homodimer interface [polypeptide binding]; other site
365044006721	oligonucleotide binding site [chemical binding]; other site
365044006722	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
365044006723	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
365044006724	putative active site [active]
365044006725	putative metal binding site [ion binding]; other site
365044006726	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044006727	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
365044006728	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044006729	Winged helix-turn helix; Region: HTH_29; pfam13551
365044006730	Winged helix-turn helix; Region: HTH_33; pfam13592
365044006731	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044006732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044006733	Transposase; Region: HTH_Tnp_1; cl17663
365044006734	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
365044006735	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
365044006736	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044006737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
365044006738	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
365044006739	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
365044006740	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006742	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006743	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006744	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006745	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006746	Transposase domain (DUF772); Region: DUF772; pfam05598
365044006747	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
365044006748	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044006749	putative transposase OrfB; Reviewed; Region: PHA02517
365044006750	HTH-like domain; Region: HTH_21; pfam13276
365044006751	Integrase core domain; Region: rve; pfam00665
365044006752	Integrase core domain; Region: rve_2; pfam13333
365044006753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006754	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006755	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006756	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044006757	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044006758	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044006759	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
365044006760	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
365044006761	BON domain; Region: BON; pfam04972
365044006762	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044006763	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
365044006764	hydroxyglutarate oxidase; Provisional; Region: PRK11728
365044006765	amidase; Provisional; Region: PRK07056
365044006766	Amidase; Region: Amidase; cl11426
365044006767	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
365044006768	rRNA interaction site [nucleotide binding]; other site
365044006769	S8 interaction site; other site
365044006770	putative laminin-1 binding site; other site
365044006771	elongation factor Ts; Provisional; Region: tsf; PRK09377
365044006772	UBA/TS-N domain; Region: UBA; pfam00627
365044006773	Elongation factor TS; Region: EF_TS; pfam00889
365044006774	Elongation factor TS; Region: EF_TS; pfam00889
365044006775	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
365044006776	putative nucleotide binding site [chemical binding]; other site
365044006777	uridine monophosphate binding site [chemical binding]; other site
365044006778	homohexameric interface [polypeptide binding]; other site
365044006779	ribosome recycling factor; Reviewed; Region: frr; PRK00083
365044006780	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
365044006781	hinge region; other site
365044006782	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
365044006783	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
365044006784	catalytic residue [active]
365044006785	putative FPP diphosphate  binding site; other site
365044006786	putative FPP binding hydrophobic cleft; other site
365044006787	dimer interface [polypeptide binding]; other site
365044006788	putative IPP diphosphate binding site; other site
365044006789	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
365044006790	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
365044006791	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
365044006792	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
365044006793	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
365044006794	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
365044006795	zinc metallopeptidase RseP; Provisional; Region: PRK10779
365044006796	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
365044006797	active site
365044006798	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
365044006799	protein binding site [polypeptide binding]; other site
365044006800	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
365044006801	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
365044006802	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
365044006803	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
365044006804	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
365044006805	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
365044006806	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
365044006807	Surface antigen; Region: Bac_surface_Ag; pfam01103
365044006808	periplasmic chaperone; Provisional; Region: PRK10780
365044006809	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
365044006810	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
365044006811	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
365044006812	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
365044006813	trimer interface [polypeptide binding]; other site
365044006814	active site
365044006815	UDP-GlcNAc binding site [chemical binding]; other site
365044006816	lipid binding site [chemical binding]; lipid-binding site
365044006817	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
365044006818	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
365044006819	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
365044006820	active site
365044006821	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
365044006822	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
365044006823	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
365044006824	RNA/DNA hybrid binding site [nucleotide binding]; other site
365044006825	active site
365044006826	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
365044006827	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
365044006828	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
365044006829	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
365044006830	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
365044006831	catalytic site [active]
365044006832	subunit interface [polypeptide binding]; other site
365044006833	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
365044006834	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044006835	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
365044006836	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
365044006837	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044006838	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365044006839	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
365044006840	substrate binding site [chemical binding]; other site
365044006841	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
365044006842	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
365044006843	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365044006844	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
365044006845	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
365044006846	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
365044006847	homodimer interface [polypeptide binding]; other site
365044006848	NADP binding site [chemical binding]; other site
365044006849	substrate binding site [chemical binding]; other site
365044006850	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
365044006851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006852	active site
365044006853	phosphorylation site [posttranslational modification]
365044006854	intermolecular recognition site; other site
365044006855	dimerization interface [polypeptide binding]; other site
365044006856	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044006857	DNA binding residues [nucleotide binding]
365044006858	dimerization interface [polypeptide binding]; other site
365044006859	PAS domain S-box; Region: sensory_box; TIGR00229
365044006860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044006861	putative active site [active]
365044006862	heme pocket [chemical binding]; other site
365044006863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044006864	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044006865	dimer interface [polypeptide binding]; other site
365044006866	phosphorylation site [posttranslational modification]
365044006867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006868	ATP binding site [chemical binding]; other site
365044006869	Mg2+ binding site [ion binding]; other site
365044006870	G-X-G motif; other site
365044006871	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
365044006872	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
365044006873	dimer interface [polypeptide binding]; other site
365044006874	TPP-binding site [chemical binding]; other site
365044006875	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
365044006876	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006877	E3 interaction surface; other site
365044006878	lipoyl attachment site [posttranslational modification]; other site
365044006879	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006880	E3 interaction surface; other site
365044006881	lipoyl attachment site [posttranslational modification]; other site
365044006882	e3 binding domain; Region: E3_binding; pfam02817
365044006883	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
365044006884	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
365044006885	active site
365044006886	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006887	E3 interaction surface; other site
365044006888	lipoyl attachment site [posttranslational modification]; other site
365044006889	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
365044006890	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044006891	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044006892	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044006893	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
365044006894	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
365044006895	NlpC/P60 family; Region: NLPC_P60; pfam00877
365044006896	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
365044006897	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
365044006898	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
365044006899	Permease; Region: Permease; pfam02405
365044006900	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
365044006901	mce related protein; Region: MCE; pfam02470
365044006902	putative chaperone; Provisional; Region: PRK11678
365044006903	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
365044006904	nucleotide binding site [chemical binding]; other site
365044006905	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365044006906	SBD interface [polypeptide binding]; other site
365044006907	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
365044006908	catalytic triad [active]
365044006909	dimer interface [polypeptide binding]; other site
365044006910	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044006911	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
365044006912	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
365044006913	Isochorismatase family; Region: Isochorismatase; pfam00857
365044006914	catalytic triad [active]
365044006915	dimer interface [polypeptide binding]; other site
365044006916	conserved cis-peptide bond; other site
365044006917	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
365044006918	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044006919	metal binding site [ion binding]; metal-binding site
365044006920	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
365044006921	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
365044006922	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
365044006923	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
365044006924	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
365044006925	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044006926	acyl-activating enzyme (AAE) consensus motif; other site
365044006927	AMP binding site [chemical binding]; other site
365044006928	active site
365044006929	CoA binding site [chemical binding]; other site
365044006930	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044006931	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044006932	Winged helix-turn helix; Region: HTH_33; pfam13592
365044006933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044006934	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
365044006935	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365044006936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365044006937	ABC transporter; Region: ABC_tran_2; pfam12848
365044006938	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044006939	Walker A/P-loop; other site
365044006940	ATP binding site [chemical binding]; other site
365044006941	Q-loop/lid; other site
365044006942	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
365044006943	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
365044006944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044006945	S-adenosylmethionine binding site [chemical binding]; other site
365044006946	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
365044006947	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
365044006948	metal binding site [ion binding]; metal-binding site
365044006949	dimer interface [polypeptide binding]; other site
365044006950	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
365044006951	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044006952	Walker A motif; other site
365044006953	ATP binding site [chemical binding]; other site
365044006954	Walker B motif; other site
365044006955	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
365044006956	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
365044006957	active site
365044006958	substrate binding site [chemical binding]; other site
365044006959	trimer interface [polypeptide binding]; other site
365044006960	CoA binding site [chemical binding]; other site
365044006961	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
365044006962	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044006963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044006964	homodimer interface [polypeptide binding]; other site
365044006965	catalytic residue [active]
365044006966	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
365044006967	AAA domain; Region: AAA_23; pfam13476
365044006968	Walker A/P-loop; other site
365044006969	ATP binding site [chemical binding]; other site
365044006970	Q-loop/lid; other site
365044006971	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
365044006972	ABC transporter signature motif; other site
365044006973	Walker B; other site
365044006974	D-loop; other site
365044006975	H-loop/switch region; other site
365044006976	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
365044006977	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
365044006978	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
365044006979	nucleotide binding pocket [chemical binding]; other site
365044006980	K-X-D-G motif; other site
365044006981	catalytic site [active]
365044006982	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
365044006983	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
365044006984	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
365044006985	Dimer interface [polypeptide binding]; other site
365044006986	Protein of unknown function (DUF454); Region: DUF454; pfam04304
365044006987	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
365044006988	active site
365044006989	catalytic residues [active]
365044006990	metal binding site [ion binding]; metal-binding site
365044006991	PII uridylyl-transferase; Provisional; Region: PRK03059
365044006992	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044006993	metal binding triad; other site
365044006994	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
365044006995	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365044006996	Zn2+ binding site [ion binding]; other site
365044006997	Mg2+ binding site [ion binding]; other site
365044006998	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
365044006999	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
365044007000	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
365044007001	active site
365044007002	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
365044007003	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
365044007004	dimerization interface [polypeptide binding]; other site
365044007005	ATP binding site [chemical binding]; other site
365044007006	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
365044007007	dimerization interface [polypeptide binding]; other site
365044007008	ATP binding site [chemical binding]; other site
365044007009	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
365044007010	putative active site [active]
365044007011	catalytic triad [active]
365044007012	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
365044007013	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044007014	oligomeric interface; other site
365044007015	putative active site [active]
365044007016	homodimer interface [polypeptide binding]; other site
365044007017	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044007018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044007019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044007020	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
365044007021	active site
365044007022	phosphate binding residues; other site
365044007023	catalytic residues [active]
365044007024	OmpW family; Region: OmpW; cl17427
365044007025	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
365044007026	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
365044007027	hydroperoxidase II; Provisional; Region: katE; PRK11249
365044007028	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
365044007029	tetramer interface [polypeptide binding]; other site
365044007030	heme binding pocket [chemical binding]; other site
365044007031	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
365044007032	domain interactions; other site
365044007033	SurA N-terminal domain; Region: SurA_N; pfam09312
365044007034	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
365044007035	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
365044007036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044007037	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
365044007038	Probable transposase; Region: OrfB_IS605; pfam01385
365044007039	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044007040	intracellular septation protein A; Reviewed; Region: PRK00259
365044007041	methionine sulfoxide reductase B; Provisional; Region: PRK00222
365044007042	SelR domain; Region: SelR; pfam01641
365044007043	Uncharacterized conserved protein [Function unknown]; Region: COG0397
365044007044	hypothetical protein; Validated; Region: PRK00029
365044007045	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
365044007046	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
365044007047	dimer interface [polypeptide binding]; other site
365044007048	acyl-activating enzyme (AAE) consensus motif; other site
365044007049	putative active site [active]
365044007050	AMP binding site [chemical binding]; other site
365044007051	putative CoA binding site [chemical binding]; other site
365044007052	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044007053	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044007054	TM-ABC transporter signature motif; other site
365044007055	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044007056	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044007057	TM-ABC transporter signature motif; other site
365044007058	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044007059	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044007060	Walker A/P-loop; other site
365044007061	ATP binding site [chemical binding]; other site
365044007062	Q-loop/lid; other site
365044007063	ABC transporter signature motif; other site
365044007064	Walker B; other site
365044007065	D-loop; other site
365044007066	H-loop/switch region; other site
365044007067	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044007068	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044007069	Walker A/P-loop; other site
365044007070	ATP binding site [chemical binding]; other site
365044007071	Q-loop/lid; other site
365044007072	ABC transporter signature motif; other site
365044007073	Walker B; other site
365044007074	D-loop; other site
365044007075	H-loop/switch region; other site
365044007076	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007077	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
365044007078	substrate binding site [chemical binding]; other site
365044007079	oxyanion hole (OAH) forming residues; other site
365044007080	trimer interface [polypeptide binding]; other site
365044007081	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
365044007082	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044007083	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044007084	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
365044007085	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044007086	dimer interface [polypeptide binding]; other site
365044007087	active site
365044007088	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
365044007089	classical (c) SDRs; Region: SDR_c; cd05233
365044007090	NAD(P) binding site [chemical binding]; other site
365044007091	active site
365044007092	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044007093	CoenzymeA binding site [chemical binding]; other site
365044007094	subunit interaction site [polypeptide binding]; other site
365044007095	PHB binding site; other site
365044007096	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
365044007097	Prostaglandin dehydrogenases; Region: PGDH; cd05288
365044007098	NAD(P) binding site [chemical binding]; other site
365044007099	substrate binding site [chemical binding]; other site
365044007100	dimer interface [polypeptide binding]; other site
365044007101	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044007102	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044007103	active site
365044007104	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044007105	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
365044007106	C-terminal domain interface [polypeptide binding]; other site
365044007107	GSH binding site (G-site) [chemical binding]; other site
365044007108	dimer interface [polypeptide binding]; other site
365044007109	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
365044007110	N-terminal domain interface [polypeptide binding]; other site
365044007111	dimer interface [polypeptide binding]; other site
365044007112	substrate binding pocket (H-site) [chemical binding]; other site
365044007113	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
365044007114	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044007115	Coenzyme A binding pocket [chemical binding]; other site
365044007116	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044007117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044007118	active site
365044007119	phosphorylation site [posttranslational modification]
365044007120	intermolecular recognition site; other site
365044007121	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044007122	DNA binding residues [nucleotide binding]
365044007123	dimerization interface [polypeptide binding]; other site
365044007124	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044007125	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
365044007126	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
365044007127	ligand binding site [chemical binding]; other site
365044007128	NAD binding site [chemical binding]; other site
365044007129	tetramer interface [polypeptide binding]; other site
365044007130	catalytic site [active]
365044007131	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
365044007132	L-serine binding site [chemical binding]; other site
365044007133	ACT domain interface; other site
365044007134	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
365044007135	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
365044007136	TPP-binding site [chemical binding]; other site
365044007137	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
365044007138	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
365044007139	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044007140	E3 interaction surface; other site
365044007141	lipoyl attachment site [posttranslational modification]; other site
365044007142	e3 binding domain; Region: E3_binding; pfam02817
365044007143	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
365044007144	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
365044007145	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044007146	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044007147	Predicted ATPase [General function prediction only]; Region: COG1485
365044007148	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
365044007149	active site
365044007150	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
365044007151	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
365044007152	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
365044007153	Outer membrane lipoprotein; Region: YfiO; pfam13525
365044007154	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365044007155	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044007156	RNA binding surface [nucleotide binding]; other site
365044007157	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365044007158	active site
365044007159	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
365044007160	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044007161	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044007162	RNA binding surface [nucleotide binding]; other site
365044007163	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044007164	active site
365044007165	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
365044007166	active site
365044007167	multimer interface [polypeptide binding]; other site
365044007168	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
365044007169	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
365044007170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044007171	binding surface
365044007172	TPR motif; other site
365044007173	Helix-turn-helix domain; Region: HTH_25; pfam13413
365044007174	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
365044007175	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
365044007176	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
365044007177	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
365044007178	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
365044007179	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
365044007180	dimer interface [polypeptide binding]; other site
365044007181	motif 1; other site
365044007182	active site
365044007183	motif 2; other site
365044007184	motif 3; other site
365044007185	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
365044007186	anticodon binding site; other site
365044007187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
365044007188	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
365044007189	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
365044007190	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
365044007191	Trp docking motif [polypeptide binding]; other site
365044007192	active site
365044007193	GTP-binding protein Der; Reviewed; Region: PRK00093
365044007194	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
365044007195	G1 box; other site
365044007196	GTP/Mg2+ binding site [chemical binding]; other site
365044007197	Switch I region; other site
365044007198	G2 box; other site
365044007199	Switch II region; other site
365044007200	G3 box; other site
365044007201	G4 box; other site
365044007202	G5 box; other site
365044007203	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
365044007204	G1 box; other site
365044007205	GTP/Mg2+ binding site [chemical binding]; other site
365044007206	Switch I region; other site
365044007207	G2 box; other site
365044007208	G3 box; other site
365044007209	Switch II region; other site
365044007210	G4 box; other site
365044007211	G5 box; other site
365044007212	bacterial Hfq-like; Region: Hfq; cd01716
365044007213	hexamer interface [polypeptide binding]; other site
365044007214	Sm1 motif; other site
365044007215	RNA binding site [nucleotide binding]; other site
365044007216	Sm2 motif; other site
365044007217	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
365044007218	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
365044007219	HflX GTPase family; Region: HflX; cd01878
365044007220	G1 box; other site
365044007221	GTP/Mg2+ binding site [chemical binding]; other site
365044007222	Switch I region; other site
365044007223	G2 box; other site
365044007224	G3 box; other site
365044007225	Switch II region; other site
365044007226	G4 box; other site
365044007227	G5 box; other site
365044007228	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
365044007229	HflK protein; Region: hflK; TIGR01933
365044007230	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
365044007231	HflK protein; Region: hflK; TIGR01933
365044007232	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
365044007233	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
365044007234	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
365044007235	dimer interface [polypeptide binding]; other site
365044007236	motif 1; other site
365044007237	active site
365044007238	motif 2; other site
365044007239	motif 3; other site
365044007240	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
365044007241	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
365044007242	GDP-binding site [chemical binding]; other site
365044007243	ACT binding site; other site
365044007244	IMP binding site; other site
365044007245	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
365044007246	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044007247	active site
365044007248	cystathionine beta-lyase; Provisional; Region: PRK07050
365044007249	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044007250	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044007251	catalytic residue [active]
365044007252	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
365044007253	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044007254	active site residue [active]
365044007255	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044007256	Walker A motif; other site
365044007257	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
365044007258	active site
365044007259	catalytic triad [active]
365044007260	oxyanion hole [active]
365044007261	switch loop; other site
365044007262	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
365044007263	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044007264	Walker A/P-loop; other site
365044007265	ATP binding site [chemical binding]; other site
365044007266	Q-loop/lid; other site
365044007267	ABC transporter signature motif; other site
365044007268	Walker B; other site
365044007269	D-loop; other site
365044007270	H-loop/switch region; other site
365044007271	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
365044007272	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
365044007273	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
365044007274	Cytochrome c; Region: Cytochrom_C; cl11414
365044007275	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
365044007276	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
365044007277	putative DNA binding site [nucleotide binding]; other site
365044007278	putative homodimer interface [polypeptide binding]; other site
365044007279	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
365044007280	intracellular protease, PfpI family; Region: PfpI; TIGR01382
365044007281	proposed catalytic triad [active]
365044007282	conserved cys residue [active]
365044007283	CHRD domain; Region: CHRD; pfam07452
365044007284	hypothetical protein; Provisional; Region: PRK01254
365044007285	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
365044007286	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
365044007287	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
365044007288	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
365044007289	Fic family protein [Function unknown]; Region: COG3177
365044007290	Fic/DOC family; Region: Fic; pfam02661
365044007291	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044007292	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044007293	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
365044007294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044007295	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
365044007296	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
365044007297	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044007298	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044007299	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044007300	Walker A/P-loop; other site
365044007301	ATP binding site [chemical binding]; other site
365044007302	Q-loop/lid; other site
365044007303	ABC transporter signature motif; other site
365044007304	Walker B; other site
365044007305	D-loop; other site
365044007306	H-loop/switch region; other site
365044007307	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044007308	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044007309	Walker A/P-loop; other site
365044007310	ATP binding site [chemical binding]; other site
365044007311	Q-loop/lid; other site
365044007312	ABC transporter signature motif; other site
365044007313	Walker B; other site
365044007314	D-loop; other site
365044007315	H-loop/switch region; other site
365044007316	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044007317	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044007318	TM-ABC transporter signature motif; other site
365044007319	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044007320	TM-ABC transporter signature motif; other site
365044007321	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044007322	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
365044007323	putative ligand binding site [chemical binding]; other site
365044007324	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
365044007325	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044007326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044007327	Winged helix-turn helix; Region: HTH_29; pfam13551
365044007328	Homeodomain-like domain; Region: HTH_23; pfam13384
365044007329	Winged helix-turn helix; Region: HTH_33; pfam13592
365044007330	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044007331	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
365044007332	FAD binding site [chemical binding]; other site
365044007333	substrate binding site [chemical binding]; other site
365044007334	catalytic base [active]
365044007335	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
365044007336	putative active site [active]
365044007337	putative substrate binding site [chemical binding]; other site
365044007338	ATP binding site [chemical binding]; other site
365044007339	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044007340	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044007341	ligand binding site [chemical binding]; other site
365044007342	flexible hinge region; other site
365044007343	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
365044007344	enoyl-CoA hydratase; Provisional; Region: PRK07511
365044007345	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007346	substrate binding site [chemical binding]; other site
365044007347	oxyanion hole (OAH) forming residues; other site
365044007348	trimer interface [polypeptide binding]; other site
365044007349	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
365044007350	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
365044007351	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044007352	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044007353	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
365044007354	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
365044007355	dimerization interface [polypeptide binding]; other site
365044007356	NAD binding site [chemical binding]; other site
365044007357	ligand binding site [chemical binding]; other site
365044007358	catalytic site [active]
365044007359	LexA repressor; Validated; Region: PRK00215
365044007360	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
365044007361	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365044007362	Catalytic site [active]
365044007363	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
365044007364	active site
365044007365	homotetramer interface [polypeptide binding]; other site
365044007366	homodimer interface [polypeptide binding]; other site
365044007367	adenylate kinase; Reviewed; Region: adk; PRK00279
365044007368	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
365044007369	AMP-binding site [chemical binding]; other site
365044007370	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
365044007371	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
365044007372	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
365044007373	Ligand binding site; other site
365044007374	oligomer interface; other site
365044007375	Uncharacterized conserved protein [Function unknown]; Region: COG2835
365044007376	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
365044007377	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
365044007378	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
365044007379	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
365044007380	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
365044007381	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
365044007382	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
365044007383	generic binding surface II; other site
365044007384	generic binding surface I; other site
365044007385	superoxide dismutase; Provisional; Region: PRK10543
365044007386	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
365044007387	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
365044007388	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
365044007389	isocitrate dehydrogenase; Validated; Region: PRK07362
365044007390	isocitrate dehydrogenase; Reviewed; Region: PRK07006
365044007391	Integrase core domain; Region: rve; pfam00665
365044007392	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
365044007393	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
365044007394	Uncharacterized conserved protein [Function unknown]; Region: COG2127
365044007395	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
365044007396	Clp amino terminal domain; Region: Clp_N; pfam02861
365044007397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007398	Walker A motif; other site
365044007399	ATP binding site [chemical binding]; other site
365044007400	Walker B motif; other site
365044007401	arginine finger; other site
365044007402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007403	Walker A motif; other site
365044007404	ATP binding site [chemical binding]; other site
365044007405	Walker B motif; other site
365044007406	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
365044007407	exonuclease I; Provisional; Region: sbcB; PRK11779
365044007408	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
365044007409	active site
365044007410	catalytic site [active]
365044007411	substrate binding site [chemical binding]; other site
365044007412	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
365044007413	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
365044007414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007415	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044007416	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
365044007417	AsnC family; Region: AsnC_trans_reg; pfam01037
365044007418	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
365044007419	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044007420	putative GSH binding site (G-site) [chemical binding]; other site
365044007421	active site cysteine [active]
365044007422	putative C-terminal domain interface [polypeptide binding]; other site
365044007423	putative dimer interface [polypeptide binding]; other site
365044007424	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
365044007425	putative N-terminal domain interface [polypeptide binding]; other site
365044007426	putative dimer interface [polypeptide binding]; other site
365044007427	putative substrate binding pocket (H-site) [chemical binding]; other site
365044007428	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
365044007429	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
365044007430	active site residue [active]
365044007431	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
365044007432	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
365044007433	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
365044007434	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
365044007435	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
365044007436	RNA binding site [nucleotide binding]; other site
365044007437	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
365044007438	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
365044007439	putative active site [active]
365044007440	metal binding site [ion binding]; metal-binding site
365044007441	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
365044007442	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
365044007443	substrate binding pocket [chemical binding]; other site
365044007444	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
365044007445	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
365044007446	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
365044007447	YceG-like family; Region: YceG; pfam02618
365044007448	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
365044007449	dimerization interface [polypeptide binding]; other site
365044007450	thymidylate kinase; Validated; Region: tmk; PRK00698
365044007451	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
365044007452	TMP-binding site; other site
365044007453	ATP-binding site [chemical binding]; other site
365044007454	DNA polymerase III subunit delta'; Validated; Region: PRK06964
365044007455	DNA polymerase III subunit delta'; Validated; Region: PRK08485
365044007456	PilZ domain; Region: PilZ; cl01260
365044007457	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
365044007458	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
365044007459	active site
365044007460	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044007461	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044007462	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044007463	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044007464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044007465	putative active site [active]
365044007466	heme pocket [chemical binding]; other site
365044007467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044007468	dimer interface [polypeptide binding]; other site
365044007469	phosphorylation site [posttranslational modification]
365044007470	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
365044007471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044007472	ATP binding site [chemical binding]; other site
365044007473	G-X-G motif; other site
365044007474	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
365044007475	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
365044007476	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
365044007477	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044007478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044007479	active site
365044007480	phosphorylation site [posttranslational modification]
365044007481	intermolecular recognition site; other site
365044007482	dimerization interface [polypeptide binding]; other site
365044007483	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007484	Walker A motif; other site
365044007485	ATP binding site [chemical binding]; other site
365044007486	Walker B motif; other site
365044007487	arginine finger; other site
365044007488	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044007489	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
365044007490	putative active site [active]
365044007491	putative substrate binding site [chemical binding]; other site
365044007492	putative cosubstrate binding site; other site
365044007493	catalytic site [active]
365044007494	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
365044007495	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044007496	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007497	substrate binding site [chemical binding]; other site
365044007498	oxyanion hole (OAH) forming residues; other site
365044007499	trimer interface [polypeptide binding]; other site
365044007500	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
365044007501	dimerization interface [polypeptide binding]; other site
365044007502	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
365044007503	ATP binding site [chemical binding]; other site
365044007504	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
365044007505	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
365044007506	HupF/HypC family; Region: HupF_HypC; pfam01455
365044007507	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
365044007508	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044007509	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
365044007510	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
365044007511	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
365044007512	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
365044007513	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
365044007514	Rubredoxin; Region: Rubredoxin; pfam00301
365044007515	iron binding site [ion binding]; other site
365044007516	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
365044007517	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
365044007518	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
365044007519	HupF/HypC family; Region: HupF_HypC; pfam01455
365044007520	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
365044007521	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
365044007522	putative substrate-binding site; other site
365044007523	nickel binding site [ion binding]; other site
365044007524	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
365044007525	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
365044007526	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
365044007527	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
365044007528	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
365044007529	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
365044007530	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
365044007531	metal ion-dependent adhesion site (MIDAS); other site
365044007532	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044007533	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
365044007534	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
365044007535	ribulose bisphosphate carboxylase; Provisional; Region: PRK13475
365044007536	Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211
365044007537	dimer interface [polypeptide binding]; other site
365044007538	active site
365044007539	catalytic residue [active]
365044007540	metal binding site [ion binding]; metal-binding site
365044007541	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044007542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044007543	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
365044007544	putative dimerization interface [polypeptide binding]; other site
365044007545	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
365044007546	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044007547	motif II; other site
365044007548	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
365044007549	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
365044007550	substrate binding site [chemical binding]; other site
365044007551	hexamer interface [polypeptide binding]; other site
365044007552	metal binding site [ion binding]; metal-binding site
365044007553	fructose-1,6-bisphosphatase family protein; Region: PLN02628
365044007554	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
365044007555	AMP binding site [chemical binding]; other site
365044007556	metal binding site [ion binding]; metal-binding site
365044007557	active site
365044007558	phosphoribulokinase; Provisional; Region: PRK15453
365044007559	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
365044007560	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365044007561	TPP-binding site [chemical binding]; other site
365044007562	dimer interface [polypeptide binding]; other site
365044007563	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044007564	PYR/PP interface [polypeptide binding]; other site
365044007565	dimer interface [polypeptide binding]; other site
365044007566	TPP binding site [chemical binding]; other site
365044007567	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044007568	phosphoglycolate phosphatase; Provisional; Region: PRK13222
365044007569	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044007570	motif II; other site
365044007571	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
365044007572	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
365044007573	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
365044007574	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
365044007575	Phosphoglycerate kinase; Region: PGK; pfam00162
365044007576	substrate binding site [chemical binding]; other site
365044007577	hinge regions; other site
365044007578	ADP binding site [chemical binding]; other site
365044007579	catalytic site [active]
365044007580	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
365044007581	intersubunit interface [polypeptide binding]; other site
365044007582	active site
365044007583	zinc binding site [ion binding]; other site
365044007584	Na+ binding site [ion binding]; other site
365044007585	Helix-turn-helix domain; Region: HTH_28; pfam13518
365044007586	Winged helix-turn helix; Region: HTH_29; pfam13551
365044007587	Homeodomain-like domain; Region: HTH_32; pfam13565
365044007588	Integrase core domain; Region: rve; pfam00665
365044007589	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
365044007590	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044007591	active site
365044007592	DNA binding site [nucleotide binding]
365044007593	Int/Topo IB signature motif; other site
365044007594	hydroperoxidase II; Provisional; Region: katE; PRK11249
365044007595	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
365044007596	heme binding pocket [chemical binding]; other site
365044007597	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
365044007598	domain interactions; other site
365044007599	cyclase homology domain; Region: CHD; cd07302
365044007600	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
365044007601	nucleotidyl binding site; other site
365044007602	metal binding site [ion binding]; metal-binding site
365044007603	dimer interface [polypeptide binding]; other site
365044007604	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
365044007605	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
365044007606	phosphopeptide binding site; other site
365044007607	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
365044007608	dimer interface [polypeptide binding]; other site
365044007609	catalytic triad [active]
365044007610	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
365044007611	nucleoside/Zn binding site; other site
365044007612	dimer interface [polypeptide binding]; other site
365044007613	catalytic motif [active]
365044007614	haloalkane dehalogenase; Provisional; Region: PRK00870
365044007615	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
365044007616	GMP synthase; Reviewed; Region: guaA; PRK00074
365044007617	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
365044007618	AMP/PPi binding site [chemical binding]; other site
365044007619	candidate oxyanion hole; other site
365044007620	catalytic triad [active]
365044007621	potential glutamine specificity residues [chemical binding]; other site
365044007622	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
365044007623	ATP Binding subdomain [chemical binding]; other site
365044007624	Ligand Binding sites [chemical binding]; other site
365044007625	Dimerization subdomain; other site
365044007626	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
365044007627	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
365044007628	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
365044007629	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
365044007630	active site
365044007631	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
365044007632	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
365044007633	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
365044007634	putative coenzyme Q binding site [chemical binding]; other site
365044007635	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
365044007636	SmpB-tmRNA interface; other site
365044007637	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
365044007638	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007639	substrate binding site [chemical binding]; other site
365044007640	oxyanion hole (OAH) forming residues; other site
365044007641	trimer interface [polypeptide binding]; other site
365044007642	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
365044007643	Predicted permeases [General function prediction only]; Region: RarD; COG2962
365044007644	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
365044007645	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
365044007646	G1 box; other site
365044007647	putative GEF interaction site [polypeptide binding]; other site
365044007648	GTP/Mg2+ binding site [chemical binding]; other site
365044007649	Switch I region; other site
365044007650	G2 box; other site
365044007651	G3 box; other site
365044007652	Switch II region; other site
365044007653	G4 box; other site
365044007654	G5 box; other site
365044007655	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
365044007656	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
365044007657	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
365044007658	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
365044007659	RNA binding site [nucleotide binding]; other site
365044007660	active site
365044007661	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
365044007662	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
365044007663	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
365044007664	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
365044007665	translation initiation factor IF-2; Region: IF-2; TIGR00487
365044007666	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
365044007667	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
365044007668	G1 box; other site
365044007669	putative GEF interaction site [polypeptide binding]; other site
365044007670	GTP/Mg2+ binding site [chemical binding]; other site
365044007671	Switch I region; other site
365044007672	G2 box; other site
365044007673	G3 box; other site
365044007674	Switch II region; other site
365044007675	G4 box; other site
365044007676	G5 box; other site
365044007677	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
365044007678	Translation-initiation factor 2; Region: IF-2; pfam11987
365044007679	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
365044007680	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
365044007681	NusA N-terminal domain; Region: NusA_N; pfam08529
365044007682	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
365044007683	RNA binding site [nucleotide binding]; other site
365044007684	homodimer interface [polypeptide binding]; other site
365044007685	NusA-like KH domain; Region: KH_5; pfam13184
365044007686	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
365044007687	G-X-X-G motif; other site
365044007688	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
365044007689	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
365044007690	ribosome maturation protein RimP; Reviewed; Region: PRK00092
365044007691	Sm and related proteins; Region: Sm_like; cl00259
365044007692	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
365044007693	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
365044007694	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365044007695	Walker A/P-loop; other site
365044007696	ATP binding site [chemical binding]; other site
365044007697	Q-loop/lid; other site
365044007698	ABC transporter signature motif; other site
365044007699	Walker B; other site
365044007700	D-loop; other site
365044007701	H-loop/switch region; other site
365044007702	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044007703	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365044007704	Walker A/P-loop; other site
365044007705	ATP binding site [chemical binding]; other site
365044007706	Q-loop/lid; other site
365044007707	ABC transporter signature motif; other site
365044007708	Walker B; other site
365044007709	D-loop; other site
365044007710	H-loop/switch region; other site
365044007711	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044007712	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
365044007713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007714	dimer interface [polypeptide binding]; other site
365044007715	conserved gate region; other site
365044007716	putative PBP binding loops; other site
365044007717	ABC-ATPase subunit interface; other site
365044007718	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
365044007719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007720	dimer interface [polypeptide binding]; other site
365044007721	conserved gate region; other site
365044007722	putative PBP binding loops; other site
365044007723	ABC-ATPase subunit interface; other site
365044007724	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365044007725	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
365044007726	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
365044007727	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
365044007728	NAD binding site [chemical binding]; other site
365044007729	homotetramer interface [polypeptide binding]; other site
365044007730	homodimer interface [polypeptide binding]; other site
365044007731	substrate binding site [chemical binding]; other site
365044007732	active site
365044007733	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
365044007734	DNA binding site [nucleotide binding]
365044007735	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
365044007736	active site
365044007737	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
365044007738	DNA binding site [nucleotide binding]
365044007739	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
365044007740	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
365044007741	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044007742	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044007743	catalytic residue [active]
365044007744	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
365044007745	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
365044007746	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
365044007747	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
365044007748	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
365044007749	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365044007750	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
365044007751	active site
365044007752	catalytic tetrad [active]
365044007753	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044007754	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365044007755	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
365044007756	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
365044007757	active site
365044007758	Fe(II) binding site [ion binding]; other site
365044007759	dimer interface [polypeptide binding]; other site
365044007760	tetramer interface [polypeptide binding]; other site
365044007761	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
365044007762	dimer interface [polypeptide binding]; other site
365044007763	tetramer interface [polypeptide binding]; other site
365044007764	active site
365044007765	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
365044007766	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
365044007767	active site
365044007768	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044007769	hypothetical protein; Provisional; Region: PRK09262
365044007770	hypothetical protein; Validated; Region: PRK06201
365044007771	Amidohydrolase; Region: Amidohydro_2; pfam04909
365044007772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
365044007773	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044007774	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044007775	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
365044007776	putative dimerization interface [polypeptide binding]; other site
365044007777	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
365044007778	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
365044007779	molybdenum-pterin binding domain; Region: Mop; TIGR00638
365044007780	molybdenum-pterin binding domain; Region: Mop; TIGR00638
365044007781	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
365044007782	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
365044007783	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
365044007784	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
365044007785	active site
365044007786	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
365044007787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007788	dimer interface [polypeptide binding]; other site
365044007789	conserved gate region; other site
365044007790	putative PBP binding loops; other site
365044007791	ABC-ATPase subunit interface; other site
365044007792	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
365044007793	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044007794	Walker A/P-loop; other site
365044007795	ATP binding site [chemical binding]; other site
365044007796	Q-loop/lid; other site
365044007797	ABC transporter signature motif; other site
365044007798	Walker B; other site
365044007799	D-loop; other site
365044007800	H-loop/switch region; other site
365044007801	TOBE domain; Region: TOBE; cl01440
365044007802	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
365044007803	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
365044007804	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
365044007805	catalytic residues [active]
365044007806	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
365044007807	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
365044007808	iron-sulfur cluster [ion binding]; other site
365044007809	[2Fe-2S] cluster binding site [ion binding]; other site
365044007810	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
365044007811	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
365044007812	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
365044007813	putative ATP binding site [chemical binding]; other site
365044007814	putative substrate interface [chemical binding]; other site
365044007815	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
365044007816	Tetratricopeptide repeat; Region: TPR_6; pfam13174
365044007817	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
365044007818	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044007819	ligand binding site [chemical binding]; other site
365044007820	translocation protein TolB; Provisional; Region: tolB; PRK02889
365044007821	TolB amino-terminal domain; Region: TolB_N; pfam04052
365044007822	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007823	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007824	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007825	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007826	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044007827	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
365044007828	Substrate binding site; other site
365044007829	metal-binding site
365044007830	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044007831	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
365044007832	putative metal binding site; other site
365044007833	O-Antigen ligase; Region: Wzy_C; pfam04932
365044007834	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
365044007835	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365044007836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044007837	Walker A/P-loop; other site
365044007838	ATP binding site [chemical binding]; other site
365044007839	Q-loop/lid; other site
365044007840	ABC transporter signature motif; other site
365044007841	Walker B; other site
365044007842	D-loop; other site
365044007843	H-loop/switch region; other site
365044007844	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
365044007845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007846	dimer interface [polypeptide binding]; other site
365044007847	conserved gate region; other site
365044007848	putative PBP binding loops; other site
365044007849	ABC-ATPase subunit interface; other site
365044007850	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044007851	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365044007852	Walker A/P-loop; other site
365044007853	ATP binding site [chemical binding]; other site
365044007854	Q-loop/lid; other site
365044007855	ABC transporter signature motif; other site
365044007856	Walker B; other site
365044007857	D-loop; other site
365044007858	H-loop/switch region; other site
365044007859	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
365044007860	translation initiation factor Sui1; Validated; Region: PRK06824
365044007861	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
365044007862	putative rRNA binding site [nucleotide binding]; other site
365044007863	Transglycosylase; Region: Transgly; pfam00912
365044007864	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
365044007865	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
365044007866	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
365044007867	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
365044007868	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
365044007869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044007870	putative substrate translocation pore; other site
365044007871	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044007872	Transglycosylase; Region: Transgly; pfam00912
365044007873	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
365044007874	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
365044007875	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
365044007876	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044007877	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
365044007878	substrate binding site [chemical binding]; other site
365044007879	ATP binding site [chemical binding]; other site
365044007880	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
365044007881	galactarate dehydratase; Region: galactar-dH20; TIGR03248
365044007882	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
365044007883	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
365044007884	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
365044007885	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
365044007886	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
365044007887	putative NAD(P) binding site [chemical binding]; other site
365044007888	catalytic Zn binding site [ion binding]; other site
365044007889	structural Zn binding site [ion binding]; other site
365044007890	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044007891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044007892	substrate binding pocket [chemical binding]; other site
365044007893	membrane-bound complex binding site; other site
365044007894	hinge residues; other site
365044007895	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044007896	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365044007897	Walker A/P-loop; other site
365044007898	ATP binding site [chemical binding]; other site
365044007899	Q-loop/lid; other site
365044007900	ABC transporter signature motif; other site
365044007901	Walker B; other site
365044007902	D-loop; other site
365044007903	H-loop/switch region; other site
365044007904	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
365044007905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007906	dimer interface [polypeptide binding]; other site
365044007907	ABC-ATPase subunit interface; other site
365044007908	putative PBP binding loops; other site
365044007909	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365044007910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007911	dimer interface [polypeptide binding]; other site
365044007912	conserved gate region; other site
365044007913	putative PBP binding loops; other site
365044007914	ABC-ATPase subunit interface; other site
365044007915	Transcriptional regulators [Transcription]; Region: FadR; COG2186
365044007916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044007917	DNA-binding site [nucleotide binding]; DNA binding site
365044007918	FCD domain; Region: FCD; pfam07729
365044007919	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
365044007920	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007922	homodimer interface [polypeptide binding]; other site
365044007923	catalytic residue [active]
365044007924	RRXRR protein; Region: RRXRR; pfam14239
365044007925	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044007926	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044007927	active site
365044007928	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
365044007929	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
365044007930	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
365044007931	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044007932	minor groove reading motif; other site
365044007933	helix-hairpin-helix signature motif; other site
365044007934	substrate binding pocket [chemical binding]; other site
365044007935	active site
365044007936	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
365044007937	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
365044007938	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
365044007939	putative substrate binding site [chemical binding]; other site
365044007940	putative ATP binding site [chemical binding]; other site
365044007941	phosphoenolpyruvate synthase; Validated; Region: PRK06464
365044007942	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
365044007943	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
365044007944	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
365044007945	FOG: CBS domain [General function prediction only]; Region: COG0517
365044007946	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
365044007947	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044007948	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044007949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044007950	Caspase domain; Region: Peptidase_C14; pfam00656
365044007951	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044007952	Ligand Binding Site [chemical binding]; other site
365044007953	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
365044007954	LabA_like proteins; Region: LabA_like; cd06167
365044007955	putative metal binding site [ion binding]; other site
365044007956	Uncharacterized conserved protein [Function unknown]; Region: COG1432
365044007957	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
365044007958	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
365044007959	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
365044007960	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
365044007961	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
365044007962	putative active site [active]
365044007963	catalytic site [active]
365044007964	putative metal binding site [ion binding]; other site
365044007965	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044007966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044007967	DNA-binding site [nucleotide binding]; DNA binding site
365044007968	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007970	homodimer interface [polypeptide binding]; other site
365044007971	catalytic residue [active]
365044007972	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044007973	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044007974	Cytochrome c; Region: Cytochrom_C; pfam00034
365044007975	Cytochrome c; Region: Cytochrom_C; cl11414
365044007976	Cytochrome c; Region: Cytochrom_C; cl11414
365044007977	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
365044007978	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044007979	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044007980	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
365044007981	probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099
365044007982	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
365044007983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044007984	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
365044007985	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
365044007986	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
365044007987	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
365044007988	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
365044007989	dimerization interface [polypeptide binding]; other site
365044007990	putative ATP binding site [chemical binding]; other site
365044007991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044007992	Coenzyme A binding pocket [chemical binding]; other site
365044007993	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
365044007994	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044007995	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
365044007996	putative active site [active]
365044007997	catalytic triad [active]
365044007998	putative dimer interface [polypeptide binding]; other site
365044007999	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
365044008000	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044008001	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044008002	DNA-binding site [nucleotide binding]; DNA binding site
365044008003	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044008004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008005	homodimer interface [polypeptide binding]; other site
365044008006	catalytic residue [active]
365044008007	benzoate transporter; Region: benE; TIGR00843
365044008008	Benzoate membrane transport protein; Region: BenE; pfam03594
365044008009	benzoate transport; Region: 2A0115; TIGR00895
365044008010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044008011	putative substrate translocation pore; other site
365044008012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044008013	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
365044008014	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
365044008015	putative NAD(P) binding site [chemical binding]; other site
365044008016	active site
365044008017	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
365044008018	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044008019	catalytic loop [active]
365044008020	iron binding site [ion binding]; other site
365044008021	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
365044008022	FAD binding pocket [chemical binding]; other site
365044008023	FAD binding motif [chemical binding]; other site
365044008024	phosphate binding motif [ion binding]; other site
365044008025	beta-alpha-beta structure motif; other site
365044008026	NAD binding pocket [chemical binding]; other site
365044008027	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044008028	inter-subunit interface; other site
365044008029	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
365044008030	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
365044008031	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
365044008032	putative alpha subunit interface [polypeptide binding]; other site
365044008033	putative active site [active]
365044008034	putative substrate binding site [chemical binding]; other site
365044008035	Fe binding site [ion binding]; other site
365044008036	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
365044008037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044008038	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
365044008039	dimerizarion interface [polypeptide binding]; other site
365044008040	CrgA pocket; other site
365044008041	substrate binding pocket [chemical binding]; other site
365044008042	Hemerythrin; Region: Hemerythrin; cd12107
365044008043	Fe binding site [ion binding]; other site
365044008044	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
365044008045	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
365044008046	dimer interface [polypeptide binding]; other site
365044008047	active site
365044008048	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044008049	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
365044008050	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
365044008051	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
365044008052	octamer interface [polypeptide binding]; other site
365044008053	active site
365044008054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044008055	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
365044008056	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044008057	dimerization interface [polypeptide binding]; other site
365044008058	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
365044008059	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
365044008060	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044008061	MarR family; Region: MarR_2; pfam12802
365044008062	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206
365044008063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044008064	NAD(P) binding site [chemical binding]; other site
365044008065	active site
365044008066	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044008067	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
365044008068	substrate binding site [chemical binding]; other site
365044008069	oxyanion hole (OAH) forming residues; other site
365044008070	trimer interface [polypeptide binding]; other site
365044008071	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
365044008072	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044008073	active site
365044008074	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
365044008075	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
365044008076	acyl-activating enzyme (AAE) consensus motif; other site
365044008077	putative AMP binding site [chemical binding]; other site
365044008078	putative active site [active]
365044008079	putative CoA binding site [chemical binding]; other site
365044008080	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044008081	enoyl-CoA hydratase; Provisional; Region: PRK05862
365044008082	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044008083	substrate binding site [chemical binding]; other site
365044008084	oxyanion hole (OAH) forming residues; other site
365044008085	trimer interface [polypeptide binding]; other site
365044008086	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044008087	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044008088	active site
365044008089	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
365044008090	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044008091	FAD binding site [chemical binding]; other site
365044008092	substrate binding pocket [chemical binding]; other site
365044008093	catalytic base [active]
365044008094	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
365044008095	Ligand binding site [chemical binding]; other site
365044008096	Electron transfer flavoprotein domain; Region: ETF; pfam01012
365044008097	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
365044008098	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
365044008099	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
365044008100	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
365044008101	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
365044008102	acyl-activating enzyme (AAE) consensus motif; other site
365044008103	putative AMP binding site [chemical binding]; other site
365044008104	putative active site [active]
365044008105	putative CoA binding site [chemical binding]; other site
365044008106	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365044008107	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
365044008108	putative NAD(P) binding site [chemical binding]; other site
365044008109	structural Zn binding site [ion binding]; other site
365044008110	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044008111	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044008112	substrate binding site [chemical binding]; other site
365044008113	oxyanion hole (OAH) forming residues; other site
365044008114	trimer interface [polypeptide binding]; other site
365044008115	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
365044008116	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
365044008117	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044008118	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044008119	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
365044008120	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044008121	dimer interface [polypeptide binding]; other site
365044008122	active site
365044008123	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044008124	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
365044008125	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
365044008126	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044008127	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044008128	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044008129	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044008130	active site
365044008131	Uncharacterized conserved protein [Function unknown]; Region: COG3777
365044008132	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
365044008133	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
365044008134	putative active site [active]
365044008135	putative catalytic site [active]
365044008136	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044008137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044008138	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
365044008139	putative dimerization interface [polypeptide binding]; other site
365044008140	cobyric acid synthase; Provisional; Region: PRK00784
365044008141	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044008142	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044008143	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
365044008144	catalytic triad [active]
365044008145	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
365044008146	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044008147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008148	homodimer interface [polypeptide binding]; other site
365044008149	catalytic residue [active]
365044008150	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
365044008151	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
365044008152	putative FMN binding site [chemical binding]; other site
365044008153	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
365044008154	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
365044008155	homodimer interface [polypeptide binding]; other site
365044008156	Walker A motif; other site
365044008157	ATP binding site [chemical binding]; other site
365044008158	hydroxycobalamin binding site [chemical binding]; other site
365044008159	Walker B motif; other site
365044008160	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
365044008161	homodimer interface [polypeptide binding]; other site
365044008162	active site
365044008163	SAM binding site [chemical binding]; other site
365044008164	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
365044008165	dimer interface [polypeptide binding]; other site
365044008166	[2Fe-2S] cluster binding site [ion binding]; other site
365044008167	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
365044008168	active site
365044008169	SAM binding site [chemical binding]; other site
365044008170	homodimer interface [polypeptide binding]; other site
365044008171	Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490
365044008172	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
365044008173	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
365044008174	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
365044008175	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
365044008176	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
365044008177	active site
365044008178	SAM binding site [chemical binding]; other site
365044008179	homodimer interface [polypeptide binding]; other site
365044008180	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
365044008181	active site
365044008182	putative homodimer interface [polypeptide binding]; other site
365044008183	SAM binding site [chemical binding]; other site
365044008184	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
365044008185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044008186	S-adenosylmethionine binding site [chemical binding]; other site
365044008187	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
365044008188	Precorrin-8X methylmutase; Region: CbiC; pfam02570
365044008189	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
365044008190	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
365044008191	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
365044008192	putative active site [active]
365044008193	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
365044008194	putative active site [active]
365044008195	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
365044008196	active site
365044008197	SAM binding site [chemical binding]; other site
365044008198	homodimer interface [polypeptide binding]; other site
365044008199	Membrane transport protein; Region: Mem_trans; cl09117
365044008200	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
365044008201	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
365044008202	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044008203	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
365044008204	dimerization interface [polypeptide binding]; other site
365044008205	ligand binding site [chemical binding]; other site
365044008206	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
365044008207	multifunctional aminopeptidase A; Provisional; Region: PRK00913
365044008208	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
365044008209	interface (dimer of trimers) [polypeptide binding]; other site
365044008210	Substrate-binding/catalytic site; other site
365044008211	Zn-binding sites [ion binding]; other site
365044008212	Predicted permeases [General function prediction only]; Region: COG0795
365044008213	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
365044008214	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
365044008215	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
365044008216	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
365044008217	putative active site [active]
365044008218	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
365044008219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044008220	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
365044008221	substrate binding site [chemical binding]; other site
365044008222	dimerization interface [polypeptide binding]; other site
365044008223	methionine aminotransferase; Validated; Region: PRK09082
365044008224	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044008225	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008226	homodimer interface [polypeptide binding]; other site
365044008227	catalytic residue [active]
365044008228	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
365044008229	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
365044008230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044008231	ATP binding site [chemical binding]; other site
365044008232	putative Mg++ binding site [ion binding]; other site
365044008233	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044008234	nucleotide binding region [chemical binding]; other site
365044008235	ATP-binding site [chemical binding]; other site
365044008236	Helicase associated domain (HA2); Region: HA2; pfam04408
365044008237	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
365044008238	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
365044008239	N-acetylglutamate synthase; Validated; Region: PRK05279
365044008240	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
365044008241	putative feedback inhibition sensing region; other site
365044008242	putative nucleotide binding site [chemical binding]; other site
365044008243	putative substrate binding site [chemical binding]; other site
365044008244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044008245	Coenzyme A binding pocket [chemical binding]; other site
365044008246	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
365044008247	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
365044008248	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044008249	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044008250	Protein export membrane protein; Region: SecD_SecF; cl14618
365044008251	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044008252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044008253	active site
365044008254	Erythromycin esterase; Region: Erythro_esteras; pfam05139
365044008255	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044008256	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
365044008257	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
365044008258	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
365044008259	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365044008260	DNA binding residues [nucleotide binding]
365044008261	putative dimer interface [polypeptide binding]; other site
365044008262	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
365044008263	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
365044008264	Family description; Region: UvrD_C_2; pfam13538
365044008265	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
365044008266	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044008267	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365044008268	catalytic residues [active]
365044008269	transcription termination factor Rho; Provisional; Region: rho; PRK09376
365044008270	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
365044008271	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
365044008272	RNA binding site [nucleotide binding]; other site
365044008273	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
365044008274	multimer interface [polypeptide binding]; other site
365044008275	Walker A motif; other site
365044008276	ATP binding site [chemical binding]; other site
365044008277	Walker B motif; other site
365044008278	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
365044008279	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
365044008280	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
365044008281	putative efflux protein, MATE family; Region: matE; TIGR00797
365044008282	cation binding site [ion binding]; other site
365044008283	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044008284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044008285	putative active site [active]
365044008286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044008287	dimer interface [polypeptide binding]; other site
365044008288	phosphorylation site [posttranslational modification]
365044008289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044008290	ATP binding site [chemical binding]; other site
365044008291	Mg2+ binding site [ion binding]; other site
365044008292	G-X-G motif; other site
365044008293	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
365044008294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044008295	active site
365044008296	phosphorylation site [posttranslational modification]
365044008297	intermolecular recognition site; other site
365044008298	dimerization interface [polypeptide binding]; other site
365044008299	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044008300	DNA binding site [nucleotide binding]
365044008301	transcriptional regulator PhoU; Provisional; Region: PRK11115
365044008302	PhoU domain; Region: PhoU; pfam01895
365044008303	PhoU domain; Region: PhoU; pfam01895
365044008304	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
365044008305	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
365044008306	Walker A/P-loop; other site
365044008307	ATP binding site [chemical binding]; other site
365044008308	Q-loop/lid; other site
365044008309	ABC transporter signature motif; other site
365044008310	Walker B; other site
365044008311	D-loop; other site
365044008312	H-loop/switch region; other site
365044008313	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
365044008314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044008315	dimer interface [polypeptide binding]; other site
365044008316	conserved gate region; other site
365044008317	putative PBP binding loops; other site
365044008318	ABC-ATPase subunit interface; other site
365044008319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044008320	dimer interface [polypeptide binding]; other site
365044008321	conserved gate region; other site
365044008322	putative PBP binding loops; other site
365044008323	ABC-ATPase subunit interface; other site
365044008324	PBP superfamily domain; Region: PBP_like_2; cl17296
365044008325	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
365044008326	Fasciclin domain; Region: Fasciclin; pfam02469
365044008327	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044008328	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
365044008329	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
365044008330	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
365044008331	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044008332	catalytic core [active]
365044008333	polyphosphate kinase; Provisional; Region: PRK05443
365044008334	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
365044008335	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
365044008336	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044008337	putative active site [active]
365044008338	catalytic site [active]
365044008339	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
365044008340	putative domain interface [polypeptide binding]; other site
365044008341	putative active site [active]
365044008342	catalytic site [active]
365044008343	thiamine pyrophosphate protein; Validated; Region: PRK08199
365044008344	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365044008345	PYR/PP interface [polypeptide binding]; other site
365044008346	dimer interface [polypeptide binding]; other site
365044008347	TPP binding site [chemical binding]; other site
365044008348	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
365044008349	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
365044008350	TPP-binding site [chemical binding]; other site
365044008351	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
365044008352	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365044008353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044008354	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044008355	putative substrate translocation pore; other site
365044008356	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044008357	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
365044008358	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
365044008359	NAD(P) binding site [chemical binding]; other site
365044008360	catalytic residues [active]
365044008361	CreA protein; Region: CreA; pfam05981
365044008362	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
365044008363	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044008364	HSP70 interaction site [polypeptide binding]; other site
365044008365	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
365044008366	substrate binding site [polypeptide binding]; other site
365044008367	dimer interface [polypeptide binding]; other site
365044008368	putative addiction module antidote; Region: doc_partner; TIGR02609
365044008369	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
365044008370	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
365044008371	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
365044008372	Clp amino terminal domain; Region: Clp_N; pfam02861
365044008373	Clp amino terminal domain; Region: Clp_N; pfam02861
365044008374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008375	Walker A motif; other site
365044008376	ATP binding site [chemical binding]; other site
365044008377	Walker B motif; other site
365044008378	arginine finger; other site
365044008379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008380	Walker A motif; other site
365044008381	ATP binding site [chemical binding]; other site
365044008382	Walker B motif; other site
365044008383	arginine finger; other site
365044008384	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
365044008385	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
365044008386	MoaE homodimer interface [polypeptide binding]; other site
365044008387	MoaD interaction [polypeptide binding]; other site
365044008388	active site residues [active]
365044008389	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
365044008390	MoaE interaction surface [polypeptide binding]; other site
365044008391	MoeB interaction surface [polypeptide binding]; other site
365044008392	thiocarboxylated glycine; other site
365044008393	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
365044008394	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
365044008395	dimer interface [polypeptide binding]; other site
365044008396	putative functional site; other site
365044008397	putative MPT binding site; other site
365044008398	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
365044008399	Walker A motif; other site
365044008400	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
365044008401	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
365044008402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008403	catalytic residue [active]
365044008404	homoserine dehydrogenase; Provisional; Region: PRK06349
365044008405	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
365044008406	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
365044008407	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
365044008408	aminotransferase AlaT; Validated; Region: PRK09265
365044008409	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044008410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008411	homodimer interface [polypeptide binding]; other site
365044008412	catalytic residue [active]
365044008413	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
365044008414	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
365044008415	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
365044008416	catalytic triad [active]
365044008417	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
365044008418	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
365044008419	putative active site [active]
365044008420	PhoH-like protein; Region: PhoH; pfam02562
365044008421	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
365044008422	catalytic residue [active]
365044008423	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
365044008424	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
365044008425	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
365044008426	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
365044008427	oligomer interface [polypeptide binding]; other site
365044008428	active site residues [active]
365044008429	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
365044008430	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
365044008431	Mor transcription activator family; Region: Mor; cl02360
365044008432	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
365044008433	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
365044008434	Helix-turn-helix domain; Region: HTH_36; pfam13730
365044008435	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
365044008436	IMP-specific 5'-nucleotidase; Region: ISN1; pfam06437
365044008437	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
365044008438	ParB-like nuclease domain; Region: ParBc; pfam02195
365044008439	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044008440	active site
365044008441	DNA binding site [nucleotide binding]
365044008442	Int/Topo IB signature motif; other site
365044008443	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
365044008444	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
365044008445	active site
365044008446	catalytic site [active]
365044008447	substrate binding site [chemical binding]; other site
365044008448	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
365044008449	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044008450	catalytic loop [active]
365044008451	iron binding site [ion binding]; other site
365044008452	chaperone protein HscA; Provisional; Region: hscA; PRK05183
365044008453	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
365044008454	nucleotide binding site [chemical binding]; other site
365044008455	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365044008456	SBD interface [polypeptide binding]; other site
365044008457	co-chaperone HscB; Provisional; Region: hscB; PRK03578
365044008458	DnaJ domain; Region: DnaJ; pfam00226
365044008459	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
365044008460	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044008461	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
365044008462	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
365044008463	trimerization site [polypeptide binding]; other site
365044008464	active site
365044008465	cysteine desulfurase; Provisional; Region: PRK14012
365044008466	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
365044008467	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044008468	catalytic residue [active]
365044008469	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
365044008470	Rrf2 family protein; Region: rrf2_super; TIGR00738
365044008471	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
365044008472	dinuclear metal binding motif [ion binding]; other site
365044008473	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
365044008474	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
365044008475	catalytic residues [active]
365044008476	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
365044008477	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
365044008478	Beta-Casp domain; Region: Beta-Casp; smart01027
365044008479	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
365044008480	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044008481	Ligand Binding Site [chemical binding]; other site
365044008482	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
365044008483	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
365044008484	putative NAD(P) binding site [chemical binding]; other site
365044008485	putative substrate binding site [chemical binding]; other site
365044008486	catalytic Zn binding site [ion binding]; other site
365044008487	structural Zn binding site [ion binding]; other site
365044008488	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
365044008489	BON domain; Region: BON; pfam04972
365044008490	BON domain; Region: BON; pfam04972
365044008491	BON domain; Region: BON; pfam04972
365044008492	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
365044008493	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
365044008494	putative dimer interface [polypeptide binding]; other site
365044008495	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044008496	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044008497	Walker A/P-loop; other site
365044008498	ATP binding site [chemical binding]; other site
365044008499	Q-loop/lid; other site
365044008500	ABC transporter signature motif; other site
365044008501	Walker B; other site
365044008502	D-loop; other site
365044008503	H-loop/switch region; other site
365044008504	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044008505	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365044008506	FtsX-like permease family; Region: FtsX; pfam02687
365044008507	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044008508	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044008509	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044008510	Ligand Binding Site [chemical binding]; other site
365044008511	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044008512	Ligand Binding Site [chemical binding]; other site
365044008513	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
365044008514	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
365044008515	NAD(P) binding site [chemical binding]; other site
365044008516	homotetramer interface [polypeptide binding]; other site
365044008517	homodimer interface [polypeptide binding]; other site
365044008518	active site
365044008519	Chromate transporter; Region: Chromate_transp; pfam02417
365044008520	Chromate transporter; Region: Chromate_transp; pfam02417
365044008521	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
365044008522	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
365044008523	active site
365044008524	catalytic residues [active]
365044008525	metal binding site [ion binding]; metal-binding site
365044008526	serine O-acetyltransferase; Region: cysE; TIGR01172
365044008527	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365044008528	trimer interface [polypeptide binding]; other site
365044008529	active site
365044008530	substrate binding site [chemical binding]; other site
365044008531	CoA binding site [chemical binding]; other site
365044008532	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
365044008533	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
365044008534	Ligand binding site [chemical binding]; other site
365044008535	Electron transfer flavoprotein domain; Region: ETF; pfam01012
365044008536	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
365044008537	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
365044008538	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
365044008539	oxidoreductase; Provisional; Region: PRK10015
365044008540	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044008541	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
365044008542	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
365044008543	dimer interface [polypeptide binding]; other site
365044008544	[2Fe-2S] cluster binding site [ion binding]; other site
365044008545	NifQ; Region: NifQ; pfam04891
365044008546	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
365044008547	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044008548	Rop-like; Region: Rop-like; pfam05082
365044008549	probable nitrogen fixation protein; Region: TIGR02935
365044008550	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
365044008551	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
365044008552	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
365044008553	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
365044008554	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
365044008555	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044008556	HSP70 interaction site [polypeptide binding]; other site
365044008557	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
365044008558	core domain interface [polypeptide binding]; other site
365044008559	delta subunit interface [polypeptide binding]; other site
365044008560	epsilon subunit interface [polypeptide binding]; other site
365044008561	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
365044008562	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365044008563	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044008564	Walker A motif; other site
365044008565	ATP binding site [chemical binding]; other site
365044008566	Walker B motif; other site
365044008567	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044008568	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
365044008569	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
365044008570	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
365044008571	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
365044008572	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
365044008573	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
365044008574	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
365044008575	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
365044008576	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
365044008577	gamma subunit interface [polypeptide binding]; other site
365044008578	epsilon subunit interface [polypeptide binding]; other site
365044008579	LBP interface [polypeptide binding]; other site
365044008580	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
365044008581	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
365044008582	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
365044008583	alpha subunit interaction interface [polypeptide binding]; other site
365044008584	Walker A motif; other site
365044008585	ATP binding site [chemical binding]; other site
365044008586	Walker B motif; other site
365044008587	inhibitor binding site; inhibition site
365044008588	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044008589	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
365044008590	diiron binding motif [ion binding]; other site
365044008591	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044008592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008593	Walker A motif; other site
365044008594	ATP binding site [chemical binding]; other site
365044008595	Walker B motif; other site
365044008596	arginine finger; other site
365044008597	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
365044008598	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044008599	catalytic loop [active]
365044008600	iron binding site [ion binding]; other site
365044008601	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
365044008602	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
365044008603	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
365044008604	MoFe protein beta/alpha subunit interactions; other site
365044008605	Beta subunit P cluster binding residues; other site
365044008606	MoFe protein beta subunit/Fe protein contacts; other site
365044008607	MoFe protein dimer/ dimer interactions; other site
365044008608	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
365044008609	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
365044008610	MoFe protein alpha/beta subunit interactions; other site
365044008611	Alpha subunit P cluster binding residues; other site
365044008612	FeMoco binding residues [chemical binding]; other site
365044008613	MoFe protein alpha subunit/Fe protein contacts; other site
365044008614	MoFe protein dimer/ dimer interactions; other site
365044008615	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
365044008616	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
365044008617	Nucleotide-binding sites [chemical binding]; other site
365044008618	Walker A motif; other site
365044008619	Switch I region of nucleotide binding site; other site
365044008620	Fe4S4 binding sites [ion binding]; other site
365044008621	Switch II region of nucleotide binding site; other site
365044008622	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044008623	apolar tunnel; other site
365044008624	heme binding site [chemical binding]; other site
365044008625	dimerization interface [polypeptide binding]; other site
365044008626	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044008627	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044008628	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
365044008629	NADPH bind site [chemical binding]; other site
365044008630	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
365044008631	putative FMN binding site [chemical binding]; other site
365044008632	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
365044008633	active site residue [active]
365044008634	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044008635	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044008636	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044008637	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
365044008638	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
365044008639	RNA polymerase sigma factor; Provisional; Region: PRK12520
365044008640	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044008641	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044008642	DNA binding residues [nucleotide binding]
365044008643	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044008644	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365044008645	catalytic residues [active]
365044008646	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
365044008647	hypothetical protein; Provisional; Region: PRK05409
365044008648	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
365044008649	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
365044008650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044008651	Walker A/P-loop; other site
365044008652	ATP binding site [chemical binding]; other site
365044008653	Q-loop/lid; other site
365044008654	ABC transporter signature motif; other site
365044008655	Walker B; other site
365044008656	D-loop; other site
365044008657	H-loop/switch region; other site
365044008658	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
365044008659	dimer interface [polypeptide binding]; other site
365044008660	putative PBP binding regions; other site
365044008661	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
365044008662	ABC-ATPase subunit  interface; other site
365044008663	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
365044008664	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
365044008665	intersubunit interface [polypeptide binding]; other site
365044008666	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
365044008667	homotrimer interface [polypeptide binding]; other site
365044008668	Walker A motif; other site
365044008669	GTP binding site [chemical binding]; other site
365044008670	Walker B motif; other site
365044008671	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
365044008672	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
365044008673	cobalamin binding residues [chemical binding]; other site
365044008674	putative BtuC binding residues; other site
365044008675	dimer interface [polypeptide binding]; other site
365044008676	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
365044008677	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044008678	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
365044008679	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
365044008680	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
365044008681	N-terminal plug; other site
365044008682	ligand-binding site [chemical binding]; other site
365044008683	Cell division protein ZapA; Region: ZapA; pfam05164
365044008684	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
365044008685	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
365044008686	SWIB/MDM2 domain; Region: SWIB; pfam02201
365044008687	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
365044008688	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
365044008689	putative active site [active]
365044008690	metal binding site [ion binding]; metal-binding site
365044008691	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
365044008692	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
365044008693	ferredoxin; Provisional; Region: PRK08764
365044008694	Putative Fe-S cluster; Region: FeS; cl17515
365044008695	4Fe-4S binding domain; Region: Fer4; pfam00037
365044008696	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
365044008697	dimerization interface [polypeptide binding]; other site
365044008698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044008699	dimer interface [polypeptide binding]; other site
365044008700	phosphorylation site [posttranslational modification]
365044008701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044008702	ATP binding site [chemical binding]; other site
365044008703	Mg2+ binding site [ion binding]; other site
365044008704	G-X-G motif; other site
365044008705	Response regulator receiver domain; Region: Response_reg; pfam00072
365044008706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044008707	active site
365044008708	phosphorylation site [posttranslational modification]
365044008709	intermolecular recognition site; other site
365044008710	dimerization interface [polypeptide binding]; other site
365044008711	Response regulator receiver domain; Region: Response_reg; pfam00072
365044008712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044008713	active site
365044008714	phosphorylation site [posttranslational modification]
365044008715	intermolecular recognition site; other site
365044008716	dimerization interface [polypeptide binding]; other site
365044008717	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
365044008718	dimer interface [polypeptide binding]; other site
365044008719	substrate binding site [chemical binding]; other site
365044008720	metal binding site [ion binding]; metal-binding site
365044008721	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
365044008722	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044008723	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
365044008724	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
365044008725	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044008726	carboxyltransferase (CT) interaction site; other site
365044008727	biotinylation site [posttranslational modification]; other site
365044008728	Uncharacterized conserved protein [Function unknown]; Region: COG1434
365044008729	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
365044008730	putative active site [active]
365044008731	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
365044008732	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
365044008733	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
365044008734	membrane ATPase/protein kinase; Provisional; Region: PRK09435
365044008735	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
365044008736	Walker A; other site
365044008737	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365044008738	G4 box; other site
365044008739	G5 box; other site
365044008740	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
365044008741	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
365044008742	active site
365044008743	substrate binding site [chemical binding]; other site
365044008744	coenzyme B12 binding site [chemical binding]; other site
365044008745	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
365044008746	B12 binding site [chemical binding]; other site
365044008747	cobalt ligand [ion binding]; other site
365044008748	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044008749	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044008750	DNA-binding site [nucleotide binding]; DNA binding site
365044008751	FCD domain; Region: FCD; pfam07729
365044008752	SpoVR family protein; Provisional; Region: PRK11767
365044008753	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
365044008754	hypothetical protein; Provisional; Region: PRK05325
365044008755	PrkA family serine protein kinase; Provisional; Region: PRK15455
365044008756	AAA ATPase domain; Region: AAA_16; pfam13191
365044008757	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
365044008758	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
365044008759	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365044008760	FMN binding site [chemical binding]; other site
365044008761	active site
365044008762	catalytic residues [active]
365044008763	substrate binding site [chemical binding]; other site
365044008764	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
365044008765	active site
365044008766	Zn binding site [ion binding]; other site
365044008767	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590
365044008768	replicative DNA helicase; Region: DnaB; TIGR00665
365044008769	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
365044008770	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
365044008771	Walker A motif; other site
365044008772	ATP binding site [chemical binding]; other site
365044008773	Walker B motif; other site
365044008774	DNA binding loops [nucleotide binding]
365044008775	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
365044008776	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
365044008777	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
365044008778	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
365044008779	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
365044008780	generic binding surface I; other site
365044008781	generic binding surface II; other site
365044008782	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
365044008783	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
365044008784	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
365044008785	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
365044008786	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044008787	binding surface
365044008788	TPR motif; other site
365044008789	TPR repeat; Region: TPR_11; pfam13414
365044008790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044008791	binding surface
365044008792	TPR motif; other site
365044008793	TPR repeat; Region: TPR_11; pfam13414
365044008794	phosphoenolpyruvate synthase; Validated; Region: PRK06464
365044008795	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
365044008796	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
365044008797	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
365044008798	PEP synthetase regulatory protein; Provisional; Region: PRK05339
365044008799	peroxiredoxin; Region: AhpC; TIGR03137
365044008800	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
365044008801	dimer interface [polypeptide binding]; other site
365044008802	decamer (pentamer of dimers) interface [polypeptide binding]; other site
365044008803	catalytic triad [active]
365044008804	peroxidatic and resolving cysteines [active]
365044008805	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
365044008806	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
365044008807	catalytic residue [active]
365044008808	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
365044008809	catalytic residues [active]
365044008810	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044008811	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044008812	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
365044008813	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
365044008814	C-terminal domain interface [polypeptide binding]; other site
365044008815	GSH binding site (G-site) [chemical binding]; other site
365044008816	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044008817	dimer interface [polypeptide binding]; other site
365044008818	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044008819	N-terminal domain interface [polypeptide binding]; other site
365044008820	dimer interface [polypeptide binding]; other site
365044008821	substrate binding pocket (H-site) [chemical binding]; other site
365044008822	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
365044008823	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
365044008824	putative active site [active]
365044008825	putative metal binding site [ion binding]; other site
365044008826	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
365044008827	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
365044008828	ATP binding site [chemical binding]; other site
365044008829	putative Mg++ binding site [ion binding]; other site
365044008830	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044008831	nucleotide binding region [chemical binding]; other site
365044008832	ATP-binding site [chemical binding]; other site
365044008833	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
365044008834	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008835	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008836	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008837	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
365044008838	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008839	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
365044008840	Thioredoxin; Region: Thioredoxin_4; pfam13462
365044008841	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
365044008842	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
365044008843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044008844	Walker A/P-loop; other site
365044008845	ATP binding site [chemical binding]; other site
365044008846	Q-loop/lid; other site
365044008847	ABC transporter signature motif; other site
365044008848	Walker B; other site
365044008849	D-loop; other site
365044008850	H-loop/switch region; other site
365044008851	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044008852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044008853	putative PBP binding loops; other site
365044008854	dimer interface [polypeptide binding]; other site
365044008855	ABC-ATPase subunit interface; other site
365044008856	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
365044008857	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
365044008858	active site
365044008859	dimer interface [polypeptide binding]; other site
365044008860	non-prolyl cis peptide bond; other site
365044008861	insertion regions; other site
365044008862	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044008863	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044008864	substrate binding pocket [chemical binding]; other site
365044008865	membrane-bound complex binding site; other site
365044008866	hinge residues; other site
365044008867	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044008868	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044008869	substrate binding pocket [chemical binding]; other site
365044008870	membrane-bound complex binding site; other site
365044008871	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044008872	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
365044008873	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044008874	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044008875	substrate binding pocket [chemical binding]; other site
365044008876	membrane-bound complex binding site; other site
365044008877	hinge residues; other site
365044008878	oxidative damage protection protein; Provisional; Region: PRK05408
365044008879	Uncharacterized conserved protein [Function unknown]; Region: COG4121
365044008880	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
365044008881	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044008882	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
365044008883	putative ligand binding site [chemical binding]; other site
365044008884	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
365044008885	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
365044008886	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
365044008887	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
365044008888	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
365044008889	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
365044008890	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044008891	Active Sites [active]
365044008892	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
365044008893	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044008894	Active Sites [active]
365044008895	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
365044008896	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365044008897	G1 box; other site
365044008898	GTP/Mg2+ binding site [chemical binding]; other site
365044008899	G2 box; other site
365044008900	Switch I region; other site
365044008901	G3 box; other site
365044008902	Switch II region; other site
365044008903	G4 box; other site
365044008904	G5 box; other site
365044008905	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
365044008906	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
365044008907	Ferredoxin [Energy production and conversion]; Region: COG1146
365044008908	4Fe-4S binding domain; Region: Fer4; pfam00037
365044008909	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
365044008910	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
365044008911	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044008912	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
365044008913	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
365044008914	dimer interface [polypeptide binding]; other site
365044008915	substrate binding site [chemical binding]; other site
365044008916	ATP binding site [chemical binding]; other site
365044008917	putative carbohydrate kinase; Provisional; Region: PRK10565
365044008918	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
365044008919	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
365044008920	putative substrate binding site [chemical binding]; other site
365044008921	putative ATP binding site [chemical binding]; other site
365044008922	YGGT family; Region: YGGT; pfam02325
365044008923	YGGT family; Region: YGGT; pfam02325
365044008924	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
365044008925	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
365044008926	RNB domain; Region: RNB; pfam00773
365044008927	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
365044008928	RNA binding site [nucleotide binding]; other site
365044008929	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
365044008930	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
365044008931	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044008932	FeS/SAM binding site; other site
365044008933	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044008934	catalytic residues [active]
365044008935	catalytic nucleophile [active]
365044008936	Recombinase; Region: Recombinase; pfam07508
365044008937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008938	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044008939	Walker A motif; other site
365044008940	ATP binding site [chemical binding]; other site
365044008941	Walker B motif; other site
365044008942	arginine finger; other site
365044008943	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
365044008944	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
365044008945	active site
365044008946	catalytic triad [active]
365044008947	Trp repressor protein; Region: Trp_repressor; cl17266
365044008948	Domain of unknown function (DUF955); Region: DUF955; pfam06114
365044008949	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044008950	Part of AAA domain; Region: AAA_19; pfam13245
365044008951	Family description; Region: UvrD_C_2; pfam13538
365044008952	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
365044008953	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
365044008954	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
365044008955	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
365044008956	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
365044008957	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
365044008958	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
365044008959	ATP binding site [chemical binding]; other site
365044008960	substrate interface [chemical binding]; other site
365044008961	exopolyphosphatase; Region: exo_poly_only; TIGR03706
365044008962	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
365044008963	maleylacetoacetate isomerase; Region: maiA; TIGR01262
365044008964	C-terminal domain interface [polypeptide binding]; other site
365044008965	GSH binding site (G-site) [chemical binding]; other site
365044008966	putative dimer interface [polypeptide binding]; other site
365044008967	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
365044008968	dimer interface [polypeptide binding]; other site
365044008969	N-terminal domain interface [polypeptide binding]; other site
365044008970	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
365044008971	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044008972	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044008973	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
365044008974	Cupin domain; Region: Cupin_2; pfam07883
365044008975	Hemerythrin-like domain; Region: Hr-like; cd12108
365044008976	Fe binding site [ion binding]; other site
365044008977	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044008978	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044008979	Walker A/P-loop; other site
365044008980	ATP binding site [chemical binding]; other site
365044008981	Q-loop/lid; other site
365044008982	ABC transporter signature motif; other site
365044008983	Walker B; other site
365044008984	D-loop; other site
365044008985	H-loop/switch region; other site
365044008986	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044008987	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044008988	Walker A/P-loop; other site
365044008989	ATP binding site [chemical binding]; other site
365044008990	Q-loop/lid; other site
365044008991	ABC transporter signature motif; other site
365044008992	Walker B; other site
365044008993	D-loop; other site
365044008994	H-loop/switch region; other site
365044008995	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044008996	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044008997	TM-ABC transporter signature motif; other site
365044008998	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044008999	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044009000	TM-ABC transporter signature motif; other site
365044009001	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044009002	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
365044009003	putative ligand binding site [chemical binding]; other site
365044009004	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
365044009005	[2Fe-2S] cluster binding site [ion binding]; other site
365044009006	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044009007	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044009008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044009009	Walker A motif; other site
365044009010	ATP binding site [chemical binding]; other site
365044009011	Walker B motif; other site
365044009012	Proline dehydrogenase; Region: Pro_dh; cl03282
365044009013	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044009014	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044009015	DNA-binding site [nucleotide binding]; DNA binding site
365044009016	FCD domain; Region: FCD; pfam07729
365044009017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044009018	Walker A motif; other site
365044009019	ATP binding site [chemical binding]; other site
365044009020	Walker B motif; other site
365044009021	arginine finger; other site
365044009022	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044009023	Integrase core domain; Region: rve; pfam00665
365044009024	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
365044009025	Transposase; Region: HTH_Tnp_1; pfam01527
365044009026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044009027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044009028	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044009029	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044009030	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044009031	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044009032	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
365044009033	Cupin domain; Region: Cupin_2; pfam07883
365044009034	glutathionine S-transferase; Provisional; Region: PRK10542
365044009035	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
365044009036	C-terminal domain interface [polypeptide binding]; other site
365044009037	GSH binding site (G-site) [chemical binding]; other site
365044009038	dimer interface [polypeptide binding]; other site
365044009039	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
365044009040	dimer interface [polypeptide binding]; other site
365044009041	N-terminal domain interface [polypeptide binding]; other site
365044009042	substrate binding pocket (H-site) [chemical binding]; other site
365044009043	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
365044009044	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
365044009045	putative catalytic residue [active]
365044009046	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
365044009047	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365044009048	putative active site [active]
365044009049	catalytic residue [active]
365044009050	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
365044009051	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
365044009052	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
365044009053	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
365044009054	active site
365044009055	Fe binding site [ion binding]; other site
365044009056	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044009057	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
365044009058	NAD(P) binding site [chemical binding]; other site
365044009059	catalytic residues [active]
365044009060	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
365044009061	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
365044009062	NAD binding site [chemical binding]; other site
365044009063	active site
365044009064	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044009065	inter-subunit interface; other site
365044009066	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
365044009067	iron-sulfur cluster [ion binding]; other site
365044009068	[2Fe-2S] cluster binding site [ion binding]; other site
365044009069	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
365044009070	beta subunit interface [polypeptide binding]; other site
365044009071	alpha subunit interface [polypeptide binding]; other site
365044009072	active site
365044009073	substrate binding site [chemical binding]; other site
365044009074	Fe binding site [ion binding]; other site
365044009075	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
365044009076	[2Fe-2S] cluster binding site [ion binding]; other site
365044009077	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044009078	inter-subunit interface; other site
365044009079	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044009080	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
365044009081	iron-sulfur cluster [ion binding]; other site
365044009082	[2Fe-2S] cluster binding site [ion binding]; other site
365044009083	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
365044009084	putative alpha subunit interface [polypeptide binding]; other site
365044009085	putative active site [active]
365044009086	putative substrate binding site [chemical binding]; other site
365044009087	Fe binding site [ion binding]; other site
365044009088	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
365044009089	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044009090	catalytic loop [active]
365044009091	iron binding site [ion binding]; other site
365044009092	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
365044009093	FAD binding pocket [chemical binding]; other site
365044009094	FAD binding motif [chemical binding]; other site
365044009095	phosphate binding motif [ion binding]; other site
365044009096	beta-alpha-beta structure motif; other site
365044009097	NAD binding pocket [chemical binding]; other site
365044009098	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044009099	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044009100	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
365044009101	substrate binding pocket [chemical binding]; other site
365044009102	dimerization interface [polypeptide binding]; other site
365044009103	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044009104	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044009105	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044009106	catalytic residue [active]
365044009107	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
365044009108	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
365044009109	ATP binding site [chemical binding]; other site
365044009110	Walker A motif; other site
365044009111	hexamer interface [polypeptide binding]; other site
365044009112	Walker B motif; other site
365044009113	Replication initiator protein A; Region: RPA; cl17860
365044009114	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044009115	putative active site [active]
365044009116	TrbC/VIRB2 family; Region: TrbC; pfam04956
365044009117	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
365044009118	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
365044009119	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
365044009120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044009121	Domain of unknown function DUF87; Region: DUF87; pfam01935
365044009122	Walker A/P-loop; other site
365044009123	ATP binding site [chemical binding]; other site
365044009124	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
365044009125	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
365044009126	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
365044009127	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044009128	active site
365044009129	metal binding site [ion binding]; metal-binding site
365044009130	interdomain interaction site; other site
365044009131	VirB8 protein; Region: VirB8; pfam04335
365044009132	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
365044009133	VirB7 interaction site; other site
365044009134	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
365044009135	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
365044009136	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365044009137	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044009138	catalytic residues [active]
365044009139	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
365044009140	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044009141	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044009142	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
365044009143	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
365044009144	ABC1 family; Region: ABC1; cl17513
365044009145	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044009146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044009147	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
365044009148	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
365044009149	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044009150	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
365044009151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
365044009152	Transposase; Region: HTH_Tnp_1; cl17663
365044009153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044009154	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
365044009155	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
365044009156	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
365044009157	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
365044009158	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
365044009159	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044009160	Walker A motif; other site
365044009161	ATP binding site [chemical binding]; other site
365044009162	Walker B motif; other site
365044009163	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
365044009164	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
365044009165	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
365044009166	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
365044009167	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
365044009168	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
365044009169	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
365044009170	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
365044009171	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
365044009172	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
365044009173	HD domain; Region: HD_4; pfam13328
365044009174	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
365044009175	synthetase active site [active]
365044009176	NTP binding site [chemical binding]; other site
365044009177	metal binding site [ion binding]; metal-binding site
365044009178	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
365044009179	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
365044009180	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365044009181	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
365044009182	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
365044009183	NAD binding site [chemical binding]; other site
365044009184	homotetramer interface [polypeptide binding]; other site
365044009185	homodimer interface [polypeptide binding]; other site
365044009186	substrate binding site [chemical binding]; other site
365044009187	active site
365044009188	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
365044009189	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
365044009190	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
365044009191	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
365044009192	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044009193	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
365044009194	putative active site [active]
365044009195	putative metal binding site [ion binding]; other site
365044009196	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044009197	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
365044009198	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
365044009199	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
365044009200	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044009201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009202	active site
365044009203	phosphorylation site [posttranslational modification]
365044009204	intermolecular recognition site; other site
365044009205	dimerization interface [polypeptide binding]; other site
365044009206	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044009207	DNA binding site [nucleotide binding]
365044009208	HAMP domain; Region: HAMP; pfam00672
365044009209	dimerization interface [polypeptide binding]; other site
365044009210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009211	dimer interface [polypeptide binding]; other site
365044009212	phosphorylation site [posttranslational modification]
365044009213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009214	ATP binding site [chemical binding]; other site
365044009215	Mg2+ binding site [ion binding]; other site
365044009216	G-X-G motif; other site
365044009217	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
365044009218	homotrimer interaction site [polypeptide binding]; other site
365044009219	zinc binding site [ion binding]; other site
365044009220	CDP-binding sites; other site
365044009221	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
365044009222	substrate binding site; other site
365044009223	dimer interface; other site
365044009224	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
365044009225	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
365044009226	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044009227	ATP binding site [chemical binding]; other site
365044009228	putative Mg++ binding site [ion binding]; other site
365044009229	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044009230	nucleotide binding region [chemical binding]; other site
365044009231	ATP-binding site [chemical binding]; other site
365044009232	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
365044009233	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
365044009234	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044009235	oligomeric interface; other site
365044009236	putative active site [active]
365044009237	homodimer interface [polypeptide binding]; other site
365044009238	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
365044009239	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
365044009240	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044009241	motif II; other site
365044009242	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
365044009243	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044009244	active site
365044009245	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
365044009246	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
365044009247	heme binding site [chemical binding]; other site
365044009248	ferroxidase pore; other site
365044009249	ferroxidase diiron center [ion binding]; other site
365044009250	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
365044009251	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
365044009252	N-terminal plug; other site
365044009253	ligand-binding site [chemical binding]; other site
365044009254	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
365044009255	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
365044009256	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
365044009257	active site
365044009258	substrate binding site [chemical binding]; other site
365044009259	FMN binding site [chemical binding]; other site
365044009260	putative catalytic residues [active]
365044009261	Imelysin; Region: Peptidase_M75; cl09159
365044009262	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
365044009263	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
365044009264	Imelysin; Region: Peptidase_M75; pfam09375
365044009265	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
365044009266	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
365044009267	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
365044009268	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
365044009269	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
365044009270	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
365044009271	TolR protein; Region: tolR; TIGR02801
365044009272	Hemin uptake protein hemP; Region: hemP; pfam10636
365044009273	Domain of unknown function (DUF336); Region: DUF336; cl01249
365044009274	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
365044009275	YccA-like proteins; Region: YccA_like; cd10433
365044009276	Winged helix-turn helix; Region: HTH_29; pfam13551
365044009277	Homeodomain-like domain; Region: HTH_23; pfam13384
365044009278	Winged helix-turn helix; Region: HTH_33; pfam13592
365044009279	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044009280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044009281	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
365044009282	TRAM domain; Region: TRAM; cl01282
365044009283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044009284	S-adenosylmethionine binding site [chemical binding]; other site
365044009285	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
365044009286	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044009287	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044009288	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
365044009289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044009290	S-adenosylmethionine binding site [chemical binding]; other site
365044009291	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
365044009292	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
365044009293	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365044009294	NAD(P) binding site [chemical binding]; other site
365044009295	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
365044009296	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044009297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044009298	LysR substrate binding domain; Region: LysR_substrate; pfam03466
365044009299	dimerization interface [polypeptide binding]; other site
365044009300	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
365044009301	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
365044009302	putative NADP binding site [chemical binding]; other site
365044009303	putative substrate binding site [chemical binding]; other site
365044009304	active site
365044009305	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
365044009306	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044009307	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
365044009308	ArsC family; Region: ArsC; pfam03960
365044009309	catalytic residues [active]
365044009310	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044009311	putative DNA binding site [nucleotide binding]; other site
365044009312	putative Zn2+ binding site [ion binding]; other site
365044009313	Low molecular weight phosphatase family; Region: LMWPc; cd00115
365044009314	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
365044009315	active site
365044009316	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
365044009317	Sodium Bile acid symporter family; Region: SBF; cl17470
365044009318	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
365044009319	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044009320	Coenzyme A binding pocket [chemical binding]; other site
365044009321	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044009322	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044009323	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044009324	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
365044009325	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
365044009326	Protein export membrane protein; Region: SecD_SecF; cl14618
365044009327	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044009328	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
365044009329	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
365044009330	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044009331	putative metal binding site [ion binding]; other site
365044009332	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044009333	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
365044009334	putative substrate binding site [chemical binding]; other site
365044009335	putative ATP binding site [chemical binding]; other site
365044009336	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
365044009337	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044009338	ligand binding site [chemical binding]; other site
365044009339	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044009340	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044009341	trimer interface [polypeptide binding]; other site
365044009342	eyelet of channel; other site
365044009343	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044009344	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
365044009345	TM-ABC transporter signature motif; other site
365044009346	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044009347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044009348	Walker A/P-loop; other site
365044009349	ATP binding site [chemical binding]; other site
365044009350	Q-loop/lid; other site
365044009351	ABC transporter signature motif; other site
365044009352	Walker B; other site
365044009353	D-loop; other site
365044009354	H-loop/switch region; other site
365044009355	RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025
365044009356	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
365044009357	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
365044009358	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
365044009359	nucleotide binding site [chemical binding]; other site
365044009360	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
365044009361	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044009362	ligand binding site [chemical binding]; other site
365044009363	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
365044009364	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
365044009365	active site
365044009366	substrate binding site [chemical binding]; other site
365044009367	metal binding site [ion binding]; metal-binding site
365044009368	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
365044009369	dihydropteroate synthase; Region: DHPS; TIGR01496
365044009370	substrate binding pocket [chemical binding]; other site
365044009371	dimer interface [polypeptide binding]; other site
365044009372	inhibitor binding site; inhibition site
365044009373	FtsH Extracellular; Region: FtsH_ext; pfam06480
365044009374	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
365044009375	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044009376	Walker A motif; other site
365044009377	ATP binding site [chemical binding]; other site
365044009378	Walker B motif; other site
365044009379	arginine finger; other site
365044009380	Peptidase family M41; Region: Peptidase_M41; pfam01434
365044009381	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
365044009382	FtsJ-like methyltransferase; Region: FtsJ; cl17430
365044009383	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
365044009384	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
365044009385	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
365044009386	active site
365044009387	Zn binding site [ion binding]; other site
365044009388	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
365044009389	catalytic residues [active]
365044009390	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
365044009391	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044009392	active site
365044009393	dimer interface [polypeptide binding]; other site
365044009394	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
365044009395	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
365044009396	quinone interaction residues [chemical binding]; other site
365044009397	active site
365044009398	catalytic residues [active]
365044009399	FMN binding site [chemical binding]; other site
365044009400	substrate binding site [chemical binding]; other site
365044009401	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
365044009402	catalytic site [active]
365044009403	putative active site [active]
365044009404	putative substrate binding site [chemical binding]; other site
365044009405	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
365044009406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044009407	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
365044009408	transcriptional regulator EutR; Provisional; Region: PRK10130
365044009409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044009410	ethanolamine permease; Region: 2A0305; TIGR00908
365044009411	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
365044009412	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
365044009413	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
365044009414	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
365044009415	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
365044009416	motif 1; other site
365044009417	active site
365044009418	motif 2; other site
365044009419	motif 3; other site
365044009420	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
365044009421	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044009422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044009423	DNA-binding site [nucleotide binding]; DNA binding site
365044009424	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044009425	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009426	homodimer interface [polypeptide binding]; other site
365044009427	catalytic residue [active]
365044009428	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
365044009429	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044009430	inhibitor-cofactor binding pocket; inhibition site
365044009431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009432	catalytic residue [active]
365044009433	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365044009434	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
365044009435	Walker A/P-loop; other site
365044009436	ATP binding site [chemical binding]; other site
365044009437	Q-loop/lid; other site
365044009438	ABC transporter signature motif; other site
365044009439	Walker B; other site
365044009440	D-loop; other site
365044009441	H-loop/switch region; other site
365044009442	TOBE domain; Region: TOBE_2; pfam08402
365044009443	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365044009444	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
365044009445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044009446	dimer interface [polypeptide binding]; other site
365044009447	conserved gate region; other site
365044009448	putative PBP binding loops; other site
365044009449	ABC-ATPase subunit interface; other site
365044009450	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
365044009451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044009452	dimer interface [polypeptide binding]; other site
365044009453	conserved gate region; other site
365044009454	putative PBP binding loops; other site
365044009455	ABC-ATPase subunit interface; other site
365044009456	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
365044009457	agmatinase; Region: agmatinase; TIGR01230
365044009458	oligomer interface [polypeptide binding]; other site
365044009459	putative active site [active]
365044009460	Mn binding site [ion binding]; other site
365044009461	succinic semialdehyde dehydrogenase; Region: PLN02278
365044009462	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
365044009463	tetramerization interface [polypeptide binding]; other site
365044009464	NAD(P) binding site [chemical binding]; other site
365044009465	catalytic residues [active]
365044009466	FMN-binding domain; Region: FMN_bind; cl01081
365044009467	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
365044009468	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044009469	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
365044009470	ApbE family; Region: ApbE; pfam02424
365044009471	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044009472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009473	active site
365044009474	phosphorylation site [posttranslational modification]
365044009475	intermolecular recognition site; other site
365044009476	dimerization interface [polypeptide binding]; other site
365044009477	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009478	DNA binding residues [nucleotide binding]
365044009479	dimerization interface [polypeptide binding]; other site
365044009480	HAMP domain; Region: HAMP; pfam00672
365044009481	dimerization interface [polypeptide binding]; other site
365044009482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009483	ATP binding site [chemical binding]; other site
365044009484	Mg2+ binding site [ion binding]; other site
365044009485	G-X-G motif; other site
365044009486	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
365044009487	Sel1-like repeats; Region: SEL1; smart00671
365044009488	Sel1-like repeats; Region: SEL1; smart00671
365044009489	integrase; Provisional; Region: PRK09692
365044009490	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
365044009491	active site
365044009492	Int/Topo IB signature motif; other site
365044009493	YcfA-like protein; Region: YcfA; pfam07927
365044009494	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
365044009495	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
365044009496	Helix-turn-helix domain; Region: HTH_39; pfam14090
365044009497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
365044009498	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044009499	active site
365044009500	metal binding site [ion binding]; metal-binding site
365044009501	interdomain interaction site; other site
365044009502	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
365044009503	NMT1/THI5 like; Region: NMT1; pfam09084
365044009504	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
365044009505	membrane-bound complex binding site; other site
365044009506	PAS domain S-box; Region: sensory_box; TIGR00229
365044009507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009508	putative active site [active]
365044009509	heme pocket [chemical binding]; other site
365044009510	PAS domain S-box; Region: sensory_box; TIGR00229
365044009511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009512	putative active site [active]
365044009513	heme pocket [chemical binding]; other site
365044009514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009515	dimer interface [polypeptide binding]; other site
365044009516	phosphorylation site [posttranslational modification]
365044009517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009518	ATP binding site [chemical binding]; other site
365044009519	Mg2+ binding site [ion binding]; other site
365044009520	G-X-G motif; other site
365044009521	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
365044009522	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
365044009523	PAS domain; Region: PAS_9; pfam13426
365044009524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009525	putative active site [active]
365044009526	heme pocket [chemical binding]; other site
365044009527	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009528	DNA binding residues [nucleotide binding]
365044009529	dimerization interface [polypeptide binding]; other site
365044009530	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
365044009531	30S subunit binding site; other site
365044009532	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
365044009533	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
365044009534	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
365044009535	tetramer interface [polypeptide binding]; other site
365044009536	heme binding pocket [chemical binding]; other site
365044009537	NADPH binding site [chemical binding]; other site
365044009538	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044009539	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
365044009540	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044009541	NAD(P) binding site [chemical binding]; other site
365044009542	catalytic residues [active]
365044009543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
365044009544	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044009545	dihydroxy-acid dehydratase; Validated; Region: PRK06131
365044009546	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
365044009547	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044009548	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
365044009549	putative dimerization interface [polypeptide binding]; other site
365044009550	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
365044009551	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
365044009552	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
365044009553	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
365044009554	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044009555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009556	dimer interface [polypeptide binding]; other site
365044009557	phosphorylation site [posttranslational modification]
365044009558	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
365044009559	ATP binding site [chemical binding]; other site
365044009560	G-X-G motif; other site
365044009561	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044009562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009563	active site
365044009564	phosphorylation site [posttranslational modification]
365044009565	intermolecular recognition site; other site
365044009566	dimerization interface [polypeptide binding]; other site
365044009567	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
365044009568	DNA binding site [nucleotide binding]
365044009569	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
365044009570	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365044009571	dimer interface [polypeptide binding]; other site
365044009572	active site
365044009573	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
365044009574	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
365044009575	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044009576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044009577	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
365044009578	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
365044009579	active site
365044009580	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044009581	active site
365044009582	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
365044009583	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
365044009584	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
365044009585	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
365044009586	Bacterial sugar transferase; Region: Bac_transf; pfam02397
365044009587	transcriptional regulator EpsA; Region: EpsA; TIGR03020
365044009588	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009589	DNA binding residues [nucleotide binding]
365044009590	dimerization interface [polypeptide binding]; other site
365044009591	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
365044009592	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
365044009593	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
365044009594	lipoyl attachment site [posttranslational modification]; other site
365044009595	glycine dehydrogenase; Provisional; Region: PRK05367
365044009596	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
365044009597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009598	tetramer interface [polypeptide binding]; other site
365044009599	catalytic residue [active]
365044009600	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
365044009601	tetramer interface [polypeptide binding]; other site
365044009602	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009603	catalytic residue [active]
365044009604	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
365044009605	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
365044009606	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
365044009607	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044009608	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009609	phosphorylation site [posttranslational modification]
365044009610	dimer interface [polypeptide binding]; other site
365044009611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009612	ATP binding site [chemical binding]; other site
365044009613	Mg2+ binding site [ion binding]; other site
365044009614	G-X-G motif; other site
365044009615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009616	Response regulator receiver domain; Region: Response_reg; pfam00072
365044009617	active site
365044009618	phosphorylation site [posttranslational modification]
365044009619	intermolecular recognition site; other site
365044009620	dimerization interface [polypeptide binding]; other site
365044009621	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044009622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009623	active site
365044009624	phosphorylation site [posttranslational modification]
365044009625	intermolecular recognition site; other site
365044009626	dimerization interface [polypeptide binding]; other site
365044009627	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009628	DNA binding residues [nucleotide binding]
365044009629	dimerization interface [polypeptide binding]; other site
365044009630	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
365044009631	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
365044009632	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
365044009633	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
365044009634	Moco binding site; other site
365044009635	metal coordination site [ion binding]; other site
365044009636	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
365044009637	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
365044009638	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044009639	catalytic loop [active]
365044009640	iron binding site [ion binding]; other site
365044009641	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
365044009642	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
365044009643	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
365044009644	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
365044009645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
365044009646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
365044009647	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
365044009648	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
365044009649	XdhC Rossmann domain; Region: XdhC_C; pfam13478
365044009650	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
365044009651	Ligand binding site; other site
365044009652	metal-binding site
365044009653	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044009654	nudix motif; other site
365044009655	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
365044009656	Coenzyme A transferase; Region: CoA_trans; smart00882
365044009657	Coenzyme A transferase; Region: CoA_trans; cl17247
365044009658	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044009659	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044009660	active site
365044009661	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
365044009662	NIPSNAP; Region: NIPSNAP; pfam07978
365044009663	NIPSNAP; Region: NIPSNAP; pfam07978
365044009664	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
365044009665	Predicted oxidoreductase [General function prediction only]; Region: COG3573
365044009666	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044009667	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044009668	putative DNA binding site [nucleotide binding]; other site
365044009669	putative Zn2+ binding site [ion binding]; other site
365044009670	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044009671	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044009672	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044009673	shikimate binding site; other site
365044009674	NAD(P) binding site [chemical binding]; other site
365044009675	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
365044009676	Predicted oxidoreductase [General function prediction only]; Region: COG3573
365044009677	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
365044009678	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044009679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044009680	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044009681	classical (c) SDRs; Region: SDR_c; cd05233
365044009682	NAD(P) binding site [chemical binding]; other site
365044009683	active site
365044009684	putative succinate dehydrogenase; Reviewed; Region: PRK12842
365044009685	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044009686	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
365044009687	NIPSNAP; Region: NIPSNAP; pfam07978
365044009688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009689	NAD(P) binding site [chemical binding]; other site
365044009690	active site
365044009691	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044009692	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044009693	TM-ABC transporter signature motif; other site
365044009694	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044009695	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044009696	TM-ABC transporter signature motif; other site
365044009697	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044009698	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044009699	Walker A/P-loop; other site
365044009700	ATP binding site [chemical binding]; other site
365044009701	Q-loop/lid; other site
365044009702	ABC transporter signature motif; other site
365044009703	Walker B; other site
365044009704	D-loop; other site
365044009705	H-loop/switch region; other site
365044009706	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044009707	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044009708	Walker A/P-loop; other site
365044009709	ATP binding site [chemical binding]; other site
365044009710	Q-loop/lid; other site
365044009711	ABC transporter signature motif; other site
365044009712	Walker B; other site
365044009713	D-loop; other site
365044009714	H-loop/switch region; other site
365044009715	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044009716	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
365044009717	putative ligand binding site [chemical binding]; other site
365044009718	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
365044009719	putative substrate binding pocket [chemical binding]; other site
365044009720	trimer interface [polypeptide binding]; other site
365044009721	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044009722	extended (e) SDRs; Region: SDR_e; cd08946
365044009723	NAD(P) binding site [chemical binding]; other site
365044009724	active site
365044009725	substrate binding site [chemical binding]; other site
365044009726	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044009727	classical (c) SDRs; Region: SDR_c; cd05233
365044009728	NAD(P) binding site [chemical binding]; other site
365044009729	active site
365044009730	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
365044009731	Low molecular weight phosphatase family; Region: LMWPc; cl00105
365044009732	active site
365044009733	Vesicle coat protein involved in Golgi to plasma membrane transport; Region: Folliculin; pfam11704
365044009734	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
365044009735	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044009736	Coenzyme A binding pocket [chemical binding]; other site
365044009737	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
365044009738	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
365044009739	FMN-binding pocket [chemical binding]; other site
365044009740	flavin binding motif; other site
365044009741	phosphate binding motif [ion binding]; other site
365044009742	beta-alpha-beta structure motif; other site
365044009743	NAD binding pocket [chemical binding]; other site
365044009744	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044009745	catalytic loop [active]
365044009746	iron binding site [ion binding]; other site
365044009747	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044009748	Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532
365044009749	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
365044009750	alpha subunit interface [polypeptide binding]; other site
365044009751	active site
365044009752	substrate binding site [chemical binding]; other site
365044009753	Fe binding site [ion binding]; other site
365044009754	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044009755	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044009756	Walker A/P-loop; other site
365044009757	ATP binding site [chemical binding]; other site
365044009758	Q-loop/lid; other site
365044009759	ABC transporter signature motif; other site
365044009760	Walker B; other site
365044009761	D-loop; other site
365044009762	H-loop/switch region; other site
365044009763	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044009764	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044009765	Walker A/P-loop; other site
365044009766	ATP binding site [chemical binding]; other site
365044009767	Q-loop/lid; other site
365044009768	ABC transporter signature motif; other site
365044009769	Walker B; other site
365044009770	D-loop; other site
365044009771	H-loop/switch region; other site
365044009772	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044009773	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044009774	TM-ABC transporter signature motif; other site
365044009775	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044009776	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044009777	TM-ABC transporter signature motif; other site
365044009778	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044009779	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
365044009780	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044009781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044009782	DNA-binding site [nucleotide binding]; DNA binding site
365044009783	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
365044009784	The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949
365044009785	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
365044009786	putative active site [active]
365044009787	Fe(II) binding site [ion binding]; other site
365044009788	putative dimer interface [polypeptide binding]; other site
365044009789	putative tetramer interface [polypeptide binding]; other site
365044009790	The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925
365044009791	putative dimer interface [polypeptide binding]; other site
365044009792	putative tetramer interface [polypeptide binding]; other site
365044009793	putative active site [active]
365044009794	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044009795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044009796	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
365044009797	substrate binding pocket [chemical binding]; other site
365044009798	dimerization interface [polypeptide binding]; other site
365044009799	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
365044009800	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
365044009801	FAD binding pocket [chemical binding]; other site
365044009802	FAD binding motif [chemical binding]; other site
365044009803	phosphate binding motif [ion binding]; other site
365044009804	beta-alpha-beta structure motif; other site
365044009805	NAD binding pocket [chemical binding]; other site
365044009806	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
365044009807	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
365044009808	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044009809	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044009810	dimerization interface [polypeptide binding]; other site
365044009811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009812	dimer interface [polypeptide binding]; other site
365044009813	phosphorylation site [posttranslational modification]
365044009814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009815	ATP binding site [chemical binding]; other site
365044009816	Mg2+ binding site [ion binding]; other site
365044009817	G-X-G motif; other site
365044009818	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044009819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009820	active site
365044009821	phosphorylation site [posttranslational modification]
365044009822	intermolecular recognition site; other site
365044009823	dimerization interface [polypeptide binding]; other site
365044009824	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044009825	DNA binding site [nucleotide binding]
365044009826	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
365044009827	dimer interface [polypeptide binding]; other site
365044009828	hypothetical protein; Provisional; Region: PRK09256
365044009829	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
365044009830	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
365044009831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044009832	motif II; other site
365044009833	short chain dehydrogenase; Provisional; Region: PRK06701
365044009834	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
365044009835	NAD binding site [chemical binding]; other site
365044009836	metal binding site [ion binding]; metal-binding site
365044009837	active site
365044009838	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
365044009839	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
365044009840	Tetramer interface [polypeptide binding]; other site
365044009841	active site
365044009842	FMN-binding site [chemical binding]; other site
365044009843	Predicted transcriptional regulator [Transcription]; Region: COG2378
365044009844	WYL domain; Region: WYL; pfam13280
365044009845	Flagellin N-methylase; Region: FliB; pfam03692
365044009846	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365044009847	G1 box; other site
365044009848	GTP/Mg2+ binding site [chemical binding]; other site
365044009849	G2 box; other site
365044009850	Switch I region; other site
365044009851	G3 box; other site
365044009852	Switch II region; other site
365044009853	G4 box; other site
365044009854	G5 box; other site
365044009855	Dynamin family; Region: Dynamin_N; pfam00350
365044009856	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
365044009857	G2 box; other site
365044009858	G3 box; other site
365044009859	Switch II region; other site
365044009860	GTP/Mg2+ binding site [chemical binding]; other site
365044009861	G4 box; other site
365044009862	G5 box; other site
365044009863	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
365044009864	G1 box; other site
365044009865	GTP/Mg2+ binding site [chemical binding]; other site
365044009866	G2 box; other site
365044009867	Switch I region; other site
365044009868	G3 box; other site
365044009869	Switch II region; other site
365044009870	G4 box; other site
365044009871	G5 box; other site
365044009872	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044009873	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
365044009874	Family description; Region: UvrD_C_2; pfam13538
365044009875	Cupin domain; Region: Cupin_2; cl17218
365044009876	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044009877	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044009878	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
365044009879	putative N-terminal domain interface [polypeptide binding]; other site
365044009880	putative dimer interface [polypeptide binding]; other site
365044009881	putative substrate binding pocket (H-site) [chemical binding]; other site
365044009882	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
365044009883	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
365044009884	FOG: CBS domain [General function prediction only]; Region: COG0517
365044009885	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
365044009886	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
365044009887	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365044009888	homodimer interface [polypeptide binding]; other site
365044009889	substrate-cofactor binding pocket; other site
365044009890	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009891	catalytic residue [active]
365044009892	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365044009893	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
365044009894	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044009895	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044009896	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
365044009897	putative dimerization interface [polypeptide binding]; other site
365044009898	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
365044009899	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044009900	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044009901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044009902	Probable transposase; Region: OrfB_IS605; pfam01385
365044009903	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044009904	NAD-dependent deacetylase; Provisional; Region: PRK00481
365044009905	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
365044009906	GYD domain; Region: GYD; pfam08734
365044009907	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044009908	FAD binding domain; Region: FAD_binding_4; pfam01565
365044009909	Berberine and berberine like; Region: BBE; pfam08031
365044009910	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044009911	catalytic residues [active]
365044009912	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
365044009913	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
365044009914	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044009915	FAD binding domain; Region: FAD_binding_4; pfam01565
365044009916	thymidylate synthase; Reviewed; Region: thyA; PRK01827
365044009917	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
365044009918	dimerization interface [polypeptide binding]; other site
365044009919	active site
365044009920	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
365044009921	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
365044009922	folate binding site [chemical binding]; other site
365044009923	NADP+ binding site [chemical binding]; other site
365044009924	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
365044009925	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365044009926	FMN binding site [chemical binding]; other site
365044009927	substrate binding site [chemical binding]; other site
365044009928	putative catalytic residue [active]
365044009929	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
365044009930	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
365044009931	putative catalytic site [active]
365044009932	putative phosphate binding site [ion binding]; other site
365044009933	active site
365044009934	metal binding site A [ion binding]; metal-binding site
365044009935	DNA binding site [nucleotide binding]
365044009936	putative AP binding site [nucleotide binding]; other site
365044009937	putative metal binding site B [ion binding]; other site
365044009938	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
365044009939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009940	active site
365044009941	phosphorylation site [posttranslational modification]
365044009942	intermolecular recognition site; other site
365044009943	dimerization interface [polypeptide binding]; other site
365044009944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044009945	Walker A motif; other site
365044009946	ATP binding site [chemical binding]; other site
365044009947	Walker B motif; other site
365044009948	arginine finger; other site
365044009949	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044009950	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044009951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009952	dimer interface [polypeptide binding]; other site
365044009953	phosphorylation site [posttranslational modification]
365044009954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009955	ATP binding site [chemical binding]; other site
365044009956	Mg2+ binding site [ion binding]; other site
365044009957	G-X-G motif; other site
365044009958	glutamine synthetase; Provisional; Region: glnA; PRK09469
365044009959	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
365044009960	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
365044009961	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
365044009962	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
365044009963	putative MPT binding site; other site
365044009964	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
365044009965	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
365044009966	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
365044009967	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
365044009968	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
365044009969	NodB motif; other site
365044009970	active site
365044009971	catalytic site [active]
365044009972	metal binding site [ion binding]; metal-binding site
365044009973	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044009974	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044009975	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044009976	RNA binding surface [nucleotide binding]; other site
365044009977	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
365044009978	active site
365044009979	uracil binding [chemical binding]; other site
365044009980	phosphoglycolate phosphatase; Provisional; Region: PRK13222
365044009981	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044009982	motif II; other site
365044009983	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
365044009984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044009985	S-adenosylmethionine binding site [chemical binding]; other site
365044009986	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
365044009987	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044009988	ligand binding site [chemical binding]; other site
365044009989	DNA gyrase subunit A; Validated; Region: PRK05560
365044009990	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
365044009991	CAP-like domain; other site
365044009992	active site
365044009993	primary dimer interface [polypeptide binding]; other site
365044009994	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009995	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009996	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009997	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009998	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009999	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044010000	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
365044010001	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
365044010002	homodimer interface [polypeptide binding]; other site
365044010003	substrate-cofactor binding pocket; other site
365044010004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010005	catalytic residue [active]
365044010006	Chorismate mutase type II; Region: CM_2; cl00693
365044010007	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
365044010008	Prephenate dehydratase; Region: PDT; pfam00800
365044010009	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
365044010010	putative L-Phe binding site [chemical binding]; other site
365044010011	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
365044010012	prephenate dehydrogenase; Validated; Region: PRK08507
365044010013	bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
365044010014	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
365044010015	hinge; other site
365044010016	active site
365044010017	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
365044010018	CMP-binding site; other site
365044010019	The sites determining sugar specificity; other site
365044010020	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
365044010021	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
365044010022	RNA binding site [nucleotide binding]; other site
365044010023	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
365044010024	RNA binding site [nucleotide binding]; other site
365044010025	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
365044010026	RNA binding site [nucleotide binding]; other site
365044010027	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
365044010028	RNA binding site [nucleotide binding]; other site
365044010029	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
365044010030	RNA binding site [nucleotide binding]; other site
365044010031	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
365044010032	RNA binding site [nucleotide binding]; other site
365044010033	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365044010034	IHF dimer interface [polypeptide binding]; other site
365044010035	IHF - DNA interface [nucleotide binding]; other site
365044010036	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
365044010037	tetratricopeptide repeat protein; Provisional; Region: PRK11788
365044010038	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044010039	binding surface
365044010040	TPR motif; other site
365044010041	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044010042	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
365044010043	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044010044	putative ribose interaction site [chemical binding]; other site
365044010045	putative ADP binding site [chemical binding]; other site
365044010046	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
365044010047	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
365044010048	NADP binding site [chemical binding]; other site
365044010049	homopentamer interface [polypeptide binding]; other site
365044010050	substrate binding site [chemical binding]; other site
365044010051	active site
365044010052	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
365044010053	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
365044010054	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
365044010055	NAD(P) binding site [chemical binding]; other site
365044010056	homotetramer interface [polypeptide binding]; other site
365044010057	homodimer interface [polypeptide binding]; other site
365044010058	active site
365044010059	putative acyltransferase; Provisional; Region: PRK05790
365044010060	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044010061	dimer interface [polypeptide binding]; other site
365044010062	active site
365044010063	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
365044010064	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
365044010065	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
365044010066	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
365044010067	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
365044010068	maleylacetoacetate isomerase; Region: maiA; TIGR01262
365044010069	C-terminal domain interface [polypeptide binding]; other site
365044010070	GSH binding site (G-site) [chemical binding]; other site
365044010071	putative dimer interface [polypeptide binding]; other site
365044010072	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
365044010073	dimer interface [polypeptide binding]; other site
365044010074	N-terminal domain interface [polypeptide binding]; other site
365044010075	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
365044010076	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
365044010077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044010078	PAS fold; Region: PAS_3; pfam08447
365044010079	putative active site [active]
365044010080	heme pocket [chemical binding]; other site
365044010081	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
365044010082	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044010083	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044010084	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044010085	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044010086	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
365044010087	nudix motif; other site
365044010088	recombination associated protein; Reviewed; Region: rdgC; PRK00321
365044010089	PAS domain; Region: PAS_9; pfam13426
365044010090	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044010091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010092	Walker A motif; other site
365044010093	ATP binding site [chemical binding]; other site
365044010094	Walker B motif; other site
365044010095	arginine finger; other site
365044010096	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044010097	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044010098	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
365044010099	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044010100	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044010101	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
365044010102	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044010103	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
365044010104	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044010105	Cytochrome c [Energy production and conversion]; Region: COG3258
365044010106	Cytochrome c; Region: Cytochrom_C; pfam00034
365044010107	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044010108	dimerization interface [polypeptide binding]; other site
365044010109	putative DNA binding site [nucleotide binding]; other site
365044010110	putative Zn2+ binding site [ion binding]; other site
365044010111	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010112	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044010113	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044010114	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044010115	Protein export membrane protein; Region: SecD_SecF; cl14618
365044010116	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
365044010117	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
365044010118	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
365044010119	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
365044010120	active site residue [active]
365044010121	OsmC-like protein; Region: OsmC; pfam02566
365044010122	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044010123	active site residue [active]
365044010124	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044010125	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044010126	Walker A/P-loop; other site
365044010127	ATP binding site [chemical binding]; other site
365044010128	Q-loop/lid; other site
365044010129	ABC transporter signature motif; other site
365044010130	Walker B; other site
365044010131	D-loop; other site
365044010132	H-loop/switch region; other site
365044010133	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044010134	FtsX-like permease family; Region: FtsX; pfam02687
365044010135	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010136	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044010137	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044010138	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
365044010139	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
365044010140	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365044010141	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044010142	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
365044010143	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
365044010144	Predicted permeases [General function prediction only]; Region: COG0701
365044010145	RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959
365044010146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044010147	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365044010148	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
365044010149	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365044010150	DNA binding residues [nucleotide binding]
365044010151	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365044010152	IHF - DNA interface [nucleotide binding]; other site
365044010153	IHF dimer interface [polypeptide binding]; other site
365044010154	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
365044010155	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
365044010156	putative tRNA-binding site [nucleotide binding]; other site
365044010157	B3/4 domain; Region: B3_4; pfam03483
365044010158	tRNA synthetase B5 domain; Region: B5; smart00874
365044010159	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
365044010160	dimer interface [polypeptide binding]; other site
365044010161	motif 1; other site
365044010162	motif 3; other site
365044010163	motif 2; other site
365044010164	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
365044010165	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
365044010166	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
365044010167	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
365044010168	dimer interface [polypeptide binding]; other site
365044010169	motif 1; other site
365044010170	active site
365044010171	motif 2; other site
365044010172	motif 3; other site
365044010173	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
365044010174	23S rRNA binding site [nucleotide binding]; other site
365044010175	L21 binding site [polypeptide binding]; other site
365044010176	L13 binding site [polypeptide binding]; other site
365044010177	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
365044010178	translation initiation factor IF-3; Region: infC; TIGR00168
365044010179	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
365044010180	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
365044010181	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
365044010182	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
365044010183	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
365044010184	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
365044010185	active site
365044010186	dimer interface [polypeptide binding]; other site
365044010187	motif 1; other site
365044010188	motif 2; other site
365044010189	motif 3; other site
365044010190	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
365044010191	anticodon binding site; other site
365044010192	isocitrate lyase; Provisional; Region: PRK15063
365044010193	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
365044010194	tetramer interface [polypeptide binding]; other site
365044010195	active site
365044010196	Mg2+/Mn2+ binding site [ion binding]; other site
365044010197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
365044010198	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
365044010199	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
365044010200	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
365044010201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044010202	dimer interface [polypeptide binding]; other site
365044010203	conserved gate region; other site
365044010204	putative PBP binding loops; other site
365044010205	ABC-ATPase subunit interface; other site
365044010206	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
365044010207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044010208	dimer interface [polypeptide binding]; other site
365044010209	conserved gate region; other site
365044010210	putative PBP binding loops; other site
365044010211	ABC-ATPase subunit interface; other site
365044010212	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
365044010213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044010214	Walker A/P-loop; other site
365044010215	ATP binding site [chemical binding]; other site
365044010216	Q-loop/lid; other site
365044010217	ABC transporter signature motif; other site
365044010218	Walker B; other site
365044010219	D-loop; other site
365044010220	H-loop/switch region; other site
365044010221	TOBE domain; Region: TOBE_2; pfam08402
365044010222	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365044010223	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
365044010224	putative aminotransferase; Validated; Region: PRK07480
365044010225	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044010226	inhibitor-cofactor binding pocket; inhibition site
365044010227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010228	catalytic residue [active]
365044010229	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
365044010230	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
365044010231	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
365044010232	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
365044010233	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
365044010234	catalytic triad [active]
365044010235	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044010236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044010237	DNA-binding site [nucleotide binding]; DNA binding site
365044010238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044010239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010240	homodimer interface [polypeptide binding]; other site
365044010241	catalytic residue [active]
365044010242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044010243	Coenzyme A binding pocket [chemical binding]; other site
365044010244	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
365044010245	EamA-like transporter family; Region: EamA; pfam00892
365044010246	EamA-like transporter family; Region: EamA; pfam00892
365044010247	malonyl-CoA synthase; Validated; Region: PRK07514
365044010248	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
365044010249	acyl-activating enzyme (AAE) consensus motif; other site
365044010250	active site
365044010251	AMP binding site [chemical binding]; other site
365044010252	CoA binding site [chemical binding]; other site
365044010253	enoyl-CoA hydratase; Provisional; Region: PRK06144
365044010254	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044010255	substrate binding site [chemical binding]; other site
365044010256	oxyanion hole (OAH) forming residues; other site
365044010257	trimer interface [polypeptide binding]; other site
365044010258	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044010259	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
365044010260	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
365044010261	GAF domain; Region: GAF_3; pfam13492
365044010262	GAF domain; Region: GAF_2; pfam13185
365044010263	PAS domain S-box; Region: sensory_box; TIGR00229
365044010264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044010265	PAS fold; Region: PAS_4; pfam08448
365044010266	putative active site [active]
365044010267	heme pocket [chemical binding]; other site
365044010268	PAS domain S-box; Region: sensory_box; TIGR00229
365044010269	PAS domain; Region: PAS_8; pfam13188
365044010270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044010271	PAS domain; Region: PAS_9; pfam13426
365044010272	putative active site [active]
365044010273	heme pocket [chemical binding]; other site
365044010274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044010275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044010276	dimer interface [polypeptide binding]; other site
365044010277	phosphorylation site [posttranslational modification]
365044010278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044010279	ATP binding site [chemical binding]; other site
365044010280	Mg2+ binding site [ion binding]; other site
365044010281	G-X-G motif; other site
365044010282	Response regulator receiver domain; Region: Response_reg; pfam00072
365044010283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044010284	active site
365044010285	phosphorylation site [posttranslational modification]
365044010286	intermolecular recognition site; other site
365044010287	dimerization interface [polypeptide binding]; other site
365044010288	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
365044010289	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044010290	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
365044010291	putative dimerization interface [polypeptide binding]; other site
365044010292	putative substrate binding pocket [chemical binding]; other site
365044010293	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
365044010294	Cytochrome c; Region: Cytochrom_C; cl11414
365044010295	acetyl-CoA synthetase; Provisional; Region: PRK00174
365044010296	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
365044010297	active site
365044010298	CoA binding site [chemical binding]; other site
365044010299	acyl-activating enzyme (AAE) consensus motif; other site
365044010300	AMP binding site [chemical binding]; other site
365044010301	acetate binding site [chemical binding]; other site
365044010302	hypothetical protein; Provisional; Region: PRK05208
365044010303	fumarate hydratase; Reviewed; Region: fumC; PRK00485
365044010304	Class II fumarases; Region: Fumarase_classII; cd01362
365044010305	active site
365044010306	tetramer interface [polypeptide binding]; other site
365044010307	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
365044010308	Fumarase C-terminus; Region: Fumerase_C; pfam05683
365044010309	glutamate racemase; Provisional; Region: PRK00865
365044010310	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044010311	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
365044010312	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010313	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044010314	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044010315	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
365044010316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044010317	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
365044010318	aspartate kinase; Reviewed; Region: PRK06635
365044010319	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
365044010320	putative nucleotide binding site [chemical binding]; other site
365044010321	putative catalytic residues [active]
365044010322	putative Mg ion binding site [ion binding]; other site
365044010323	putative aspartate binding site [chemical binding]; other site
365044010324	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
365044010325	putative allosteric regulatory site; other site
365044010326	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
365044010327	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
365044010328	Ligand Binding Site [chemical binding]; other site
365044010329	TilS substrate binding domain; Region: TilS; pfam09179
365044010330	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
365044010331	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
365044010332	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044010333	endonuclease III; Region: ENDO3c; smart00478
365044010334	minor groove reading motif; other site
365044010335	helix-hairpin-helix signature motif; other site
365044010336	substrate binding pocket [chemical binding]; other site
365044010337	active site
365044010338	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
365044010339	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
365044010340	active site
365044010341	HIGH motif; other site
365044010342	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
365044010343	KMSKS motif; other site
365044010344	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
365044010345	tRNA binding surface [nucleotide binding]; other site
365044010346	anticodon binding site; other site
365044010347	TPR repeat; Region: TPR_11; pfam13414
365044010348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044010349	TPR motif; other site
365044010350	binding surface
365044010351	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
365044010352	active site
365044010353	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
365044010354	substrate binding site [chemical binding]; other site
365044010355	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044010356	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
365044010357	putative active site [active]
365044010358	putative metal binding site [ion binding]; other site
365044010359	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
365044010360	Winged helix-turn helix; Region: HTH_29; pfam13551
365044010361	Homeodomain-like domain; Region: HTH_32; pfam13565
365044010362	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044010363	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
365044010364	Methyltransferase domain; Region: Methyltransf_26; pfam13659
365044010365	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
365044010366	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
365044010367	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
365044010368	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
365044010369	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
365044010370	OmpA family; Region: OmpA; pfam00691
365044010371	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
365044010372	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
365044010373	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044010374	catalytic residue [active]
365044010375	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
365044010376	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
365044010377	dimer interface [polypeptide binding]; other site
365044010378	active site
365044010379	glycine-pyridoxal phosphate binding site [chemical binding]; other site
365044010380	folate binding site [chemical binding]; other site
365044010381	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
365044010382	ATP cone domain; Region: ATP-cone; pfam03477
365044010383	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
365044010384	Type II transport protein GspH; Region: GspH; pfam12019
365044010385	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
365044010386	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
365044010387	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
365044010388	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
365044010389	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
365044010390	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
365044010391	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
365044010392	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
365044010393	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
365044010394	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
365044010395	catalytic motif [active]
365044010396	Zn binding site [ion binding]; other site
365044010397	RibD C-terminal domain; Region: RibD_C; cl17279
365044010398	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
365044010399	Lumazine binding domain; Region: Lum_binding; pfam00677
365044010400	Lumazine binding domain; Region: Lum_binding; pfam00677
365044010401	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
365044010402	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
365044010403	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
365044010404	dimerization interface [polypeptide binding]; other site
365044010405	active site
365044010406	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
365044010407	homopentamer interface [polypeptide binding]; other site
365044010408	active site
365044010409	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
365044010410	putative RNA binding site [nucleotide binding]; other site
365044010411	aminotransferase; Validated; Region: PRK07337
365044010412	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044010413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010414	homodimer interface [polypeptide binding]; other site
365044010415	catalytic residue [active]
365044010416	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044010417	active site
365044010418	TolQ protein; Region: tolQ; TIGR02796
365044010419	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
365044010420	TolR protein; Region: tolR; TIGR02801
365044010421	TolA protein; Region: tolA_full; TIGR02794
365044010422	TonB C terminal; Region: TonB_2; pfam13103
365044010423	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
365044010424	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
365044010425	putative active site [active]
365044010426	putative PHP Thumb interface [polypeptide binding]; other site
365044010427	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
365044010428	generic binding surface II; other site
365044010429	generic binding surface I; other site
365044010430	rhodanese superfamily protein; Provisional; Region: PRK05320
365044010431	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
365044010432	active site residue [active]
365044010433	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
365044010434	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
365044010435	Pirin-related protein [General function prediction only]; Region: COG1741
365044010436	Pirin; Region: Pirin; pfam02678
365044010437	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
365044010438	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
365044010439	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
365044010440	SURF4 family; Region: SURF4; pfam02077
365044010441	Pirin-related protein [General function prediction only]; Region: COG1741
365044010442	Pirin; Region: Pirin; pfam02678
365044010443	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
365044010444	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044010445	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044010446	dimerization interface [polypeptide binding]; other site
365044010447	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
365044010448	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
365044010449	HIRAN domain; Region: HIRAN; cl07418
365044010450	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
365044010451	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
365044010452	active site
365044010453	HIGH motif; other site
365044010454	nucleotide binding site [chemical binding]; other site
365044010455	active site
365044010456	KMSKS motif; other site
365044010457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044010458	S-adenosylmethionine binding site [chemical binding]; other site
365044010459	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
365044010460	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
365044010461	probable active site [active]
365044010462	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044010463	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044010464	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044010465	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365044010466	catalytic residues [active]
365044010467	3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279
365044010468	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
365044010469	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044010470	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044010471	enoyl-CoA hydratase; Provisional; Region: PRK05995
365044010472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044010473	substrate binding site [chemical binding]; other site
365044010474	oxyanion hole (OAH) forming residues; other site
365044010475	trimer interface [polypeptide binding]; other site
365044010476	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
365044010477	4Fe-4S binding domain; Region: Fer4; pfam00037
365044010478	4Fe-4S binding domain; Region: Fer4; pfam00037
365044010479	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
365044010480	FAD binding pocket [chemical binding]; other site
365044010481	conserved FAD binding motif [chemical binding]; other site
365044010482	phosphate binding motif [ion binding]; other site
365044010483	beta-alpha-beta structure motif; other site
365044010484	NAD binding pocket [chemical binding]; other site
365044010485	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
365044010486	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
365044010487	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044010488	substrate binding site [chemical binding]; other site
365044010489	oxyanion hole (OAH) forming residues; other site
365044010490	trimer interface [polypeptide binding]; other site
365044010491	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
365044010492	oxyanion hole (OAH) forming residues; other site
365044010493	trimer interface [polypeptide binding]; other site
365044010494	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
365044010495	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044010496	non-specific DNA binding site [nucleotide binding]; other site
365044010497	salt bridge; other site
365044010498	sequence-specific DNA binding site [nucleotide binding]; other site
365044010499	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
365044010500	ADP binding site [chemical binding]; other site
365044010501	magnesium binding site [ion binding]; other site
365044010502	putative shikimate binding site; other site
365044010503	aldehyde dehydrogenase; Provisional; Region: PRK11903
365044010504	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044010505	NAD(P) binding site [chemical binding]; other site
365044010506	catalytic residues [active]
365044010507	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044010508	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
365044010509	acyl-activating enzyme (AAE) consensus motif; other site
365044010510	AMP binding site [chemical binding]; other site
365044010511	active site
365044010512	CoA binding site [chemical binding]; other site
365044010513	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044010514	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044010515	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
365044010516	putative ligand binding site [chemical binding]; other site
365044010517	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044010518	TM-ABC transporter signature motif; other site
365044010519	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044010520	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044010521	TM-ABC transporter signature motif; other site
365044010522	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044010523	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044010524	Walker A/P-loop; other site
365044010525	ATP binding site [chemical binding]; other site
365044010526	Q-loop/lid; other site
365044010527	ABC transporter signature motif; other site
365044010528	Walker B; other site
365044010529	D-loop; other site
365044010530	H-loop/switch region; other site
365044010531	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044010532	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044010533	Walker A/P-loop; other site
365044010534	ATP binding site [chemical binding]; other site
365044010535	Q-loop/lid; other site
365044010536	ABC transporter signature motif; other site
365044010537	Walker B; other site
365044010538	D-loop; other site
365044010539	H-loop/switch region; other site
365044010540	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
365044010541	Found in ATP-dependent protease La (LON); Region: LON; smart00464
365044010542	Found in ATP-dependent protease La (LON); Region: LON; smart00464
365044010543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010544	Walker A motif; other site
365044010545	ATP binding site [chemical binding]; other site
365044010546	Walker B motif; other site
365044010547	arginine finger; other site
365044010548	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
365044010549	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
365044010550	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
365044010551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010552	Walker A motif; other site
365044010553	ATP binding site [chemical binding]; other site
365044010554	Walker B motif; other site
365044010555	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
365044010556	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
365044010557	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
365044010558	oligomer interface [polypeptide binding]; other site
365044010559	active site residues [active]
365044010560	trigger factor; Provisional; Region: tig; PRK01490
365044010561	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
365044010562	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
365044010563	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044010564	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010565	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044010566	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044010567	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
365044010568	active site lid residues [active]
365044010569	substrate binding pocket [chemical binding]; other site
365044010570	catalytic residues [active]
365044010571	substrate-Mg2+ binding site; other site
365044010572	aspartate-rich region 1; other site
365044010573	aspartate-rich region 2; other site
365044010574	DNA protecting protein DprA; Region: dprA; TIGR00732
365044010575	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
365044010576	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044010577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044010578	ATP binding site [chemical binding]; other site
365044010579	putative Mg++ binding site [ion binding]; other site
365044010580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044010581	nucleotide binding region [chemical binding]; other site
365044010582	ATP-binding site [chemical binding]; other site
365044010583	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
365044010584	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
365044010585	catalytic residues [active]
365044010586	substrate binding pocket [chemical binding]; other site
365044010587	substrate-Mg2+ binding site; other site
365044010588	aspartate-rich region 1; other site
365044010589	aspartate-rich region 2; other site
365044010590	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044010591	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
365044010592	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
365044010593	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044010594	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010595	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044010596	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044010597	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044010598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044010599	active site
365044010600	phosphorylation site [posttranslational modification]
365044010601	intermolecular recognition site; other site
365044010602	dimerization interface [polypeptide binding]; other site
365044010603	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044010604	DNA binding site [nucleotide binding]
365044010605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044010606	HAMP domain; Region: HAMP; pfam00672
365044010607	dimerization interface [polypeptide binding]; other site
365044010608	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044010609	dimer interface [polypeptide binding]; other site
365044010610	phosphorylation site [posttranslational modification]
365044010611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044010612	ATP binding site [chemical binding]; other site
365044010613	Mg2+ binding site [ion binding]; other site
365044010614	G-X-G motif; other site
365044010615	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
365044010616	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
365044010617	ferrochelatase; Reviewed; Region: hemH; PRK00035
365044010618	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
365044010619	C-terminal domain interface [polypeptide binding]; other site
365044010620	active site
365044010621	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
365044010622	active site
365044010623	N-terminal domain interface [polypeptide binding]; other site
365044010624	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
365044010625	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044010626	motif II; other site
365044010627	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
365044010628	putative active site [active]
365044010629	putative catalytic site [active]
365044010630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044010631	putative substrate translocation pore; other site
365044010632	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044010633	Transcriptional regulators [Transcription]; Region: MarR; COG1846
365044010634	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044010635	putative Zn2+ binding site [ion binding]; other site
365044010636	putative DNA binding site [nucleotide binding]; other site
365044010637	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044010638	CoenzymeA binding site [chemical binding]; other site
365044010639	subunit interaction site [polypeptide binding]; other site
365044010640	PHB binding site; other site
365044010641	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
365044010642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010643	Walker A motif; other site
365044010644	ATP binding site [chemical binding]; other site
365044010645	Walker B motif; other site
365044010646	arginine finger; other site
365044010647	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
365044010648	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
365044010649	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
365044010650	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
365044010651	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044010652	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
365044010653	dimer interface [polypeptide binding]; other site
365044010654	active site
365044010655	metal binding site [ion binding]; metal-binding site
365044010656	glutathione binding site [chemical binding]; other site
365044010657	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
365044010658	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
365044010659	active site
365044010660	intersubunit interface [polypeptide binding]; other site
365044010661	catalytic residue [active]
365044010662	phosphogluconate dehydratase; Validated; Region: PRK09054
365044010663	6-phosphogluconate dehydratase; Region: edd; TIGR01196
365044010664	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044010665	ligand binding site [chemical binding]; other site
365044010666	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
365044010667	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
365044010668	putative active site pocket [active]
365044010669	dimerization interface [polypeptide binding]; other site
365044010670	putative catalytic residue [active]
365044010671	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
365044010672	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
365044010673	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
365044010674	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
365044010675	catalytic center binding site [active]
365044010676	ATP binding site [chemical binding]; other site
365044010677	poly(A) polymerase; Region: pcnB; TIGR01942
365044010678	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
365044010679	active site
365044010680	NTP binding site [chemical binding]; other site
365044010681	metal binding triad [ion binding]; metal-binding site
365044010682	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
365044010683	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
365044010684	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
365044010685	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
365044010686	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
365044010687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010688	Walker A motif; other site
365044010689	ATP binding site [chemical binding]; other site
365044010690	Walker B motif; other site
365044010691	arginine finger; other site
365044010692	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
365044010693	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
365044010694	dimerization interface [polypeptide binding]; other site
365044010695	putative ATP binding site [chemical binding]; other site
365044010696	Winged helix-turn helix; Region: HTH_29; pfam13551
365044010697	Homeodomain-like domain; Region: HTH_32; pfam13565
365044010698	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044010699	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
365044010700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
365044010701	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044010702	non-specific DNA binding site [nucleotide binding]; other site
365044010703	salt bridge; other site
365044010704	sequence-specific DNA binding site [nucleotide binding]; other site
365044010705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044010706	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044010707	putative substrate translocation pore; other site
365044010708	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
365044010709	catalytic triad [active]
365044010710	conserved cis-peptide bond; other site
365044010711	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
365044010712	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
365044010713	conserved cys residue [active]
365044010714	Uncharacterized conserved protein [Function unknown]; Region: COG2912
365044010715	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
365044010716	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
365044010717	MviN-like protein; Region: MVIN; pfam03023
365044010718	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
365044010719	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
365044010720	N-terminal plug; other site
365044010721	ligand-binding site [chemical binding]; other site
365044010722	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044010723	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044010724	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044010725	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
365044010726	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
365044010727	Trp docking motif [polypeptide binding]; other site
365044010728	active site
365044010729	Cytochrome c553 [Energy production and conversion]; Region: COG2863
365044010730	Cytochrome c; Region: Cytochrom_C; cl11414
365044010731	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
365044010732	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
365044010733	acetylornithine aminotransferase; Provisional; Region: PRK02627
365044010734	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044010735	inhibitor-cofactor binding pocket; inhibition site
365044010736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010737	catalytic residue [active]
365044010738	ornithine carbamoyltransferase; Provisional; Region: PRK00779
365044010739	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
365044010740	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
365044010741	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044010742	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044010743	NAD(P) binding site [chemical binding]; other site
365044010744	catalytic residues [active]
365044010745	Protein of unknown function (DUF779); Region: DUF779; pfam05610
365044010746	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
365044010747	classical (c) SDRs; Region: SDR_c; cd05233
365044010748	NAD(P) binding site [chemical binding]; other site
365044010749	active site
365044010750	Putative cyclase; Region: Cyclase; cl00814
365044010751	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
365044010752	kynureninase; Region: kynureninase; TIGR01814
365044010753	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044010754	catalytic residue [active]
365044010755	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
365044010756	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
365044010757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
365044010758	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
365044010759	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
365044010760	salicylate hydroxylase; Provisional; Region: PRK08163
365044010761	aconitate hydratase; Provisional; Region: acnA; PRK12881
365044010762	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
365044010763	substrate binding site [chemical binding]; other site
365044010764	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
365044010765	ligand binding site [chemical binding]; other site
365044010766	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
365044010767	substrate binding site [chemical binding]; other site
365044010768	putative protease; Provisional; Region: PRK15452
365044010769	Peptidase family U32; Region: Peptidase_U32; pfam01136
365044010770	Transposase IS200 like; Region: Y1_Tnp; cl00848
365044010771	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
365044010772	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
365044010773	substrate binding site [chemical binding]; other site
365044010774	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
365044010775	substrate binding site [chemical binding]; other site
365044010776	ligand binding site [chemical binding]; other site
365044010777	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
365044010778	malate dehydrogenase; Provisional; Region: PRK05442
365044010779	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
365044010780	NAD(P) binding site [chemical binding]; other site
365044010781	dimer interface [polypeptide binding]; other site
365044010782	malate binding site [chemical binding]; other site
365044010783	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
365044010784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044010785	DNA-binding site [nucleotide binding]; DNA binding site
365044010786	UTRA domain; Region: UTRA; pfam07702
365044010787	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
365044010788	Iron-sulfur protein interface; other site
365044010789	proximal quinone binding site [chemical binding]; other site
365044010790	SdhD (CybS) interface [polypeptide binding]; other site
365044010791	proximal heme binding site [chemical binding]; other site
365044010792	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
365044010793	SdhC subunit interface [polypeptide binding]; other site
365044010794	proximal heme binding site [chemical binding]; other site
365044010795	cardiolipin binding site; other site
365044010796	Iron-sulfur protein interface; other site
365044010797	proximal quinone binding site [chemical binding]; other site
365044010798	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
365044010799	L-aspartate oxidase; Provisional; Region: PRK06175
365044010800	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
365044010801	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
365044010802	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
365044010803	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
365044010804	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
365044010805	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
365044010806	dimer interface [polypeptide binding]; other site
365044010807	active site
365044010808	citrylCoA binding site [chemical binding]; other site
365044010809	NADH binding [chemical binding]; other site
365044010810	cationic pore residues; other site
365044010811	oxalacetate/citrate binding site [chemical binding]; other site
365044010812	coenzyme A binding site [chemical binding]; other site
365044010813	catalytic triad [active]
365044010814	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044010815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044010816	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
365044010817	putative dimerization interface [polypeptide binding]; other site
365044010818	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
365044010819	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
365044010820	substrate binding site [chemical binding]; other site
365044010821	ligand binding site [chemical binding]; other site
365044010822	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
365044010823	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
365044010824	substrate binding site [chemical binding]; other site
365044010825	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
365044010826	tartrate dehydrogenase; Region: TTC; TIGR02089
365044010827	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
365044010828	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
365044010829	FimV N-terminal domain; Region: FimV_core; TIGR03505
365044010830	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
365044010831	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
365044010832	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
365044010833	dimerization interface 3.5A [polypeptide binding]; other site
365044010834	active site
365044010835	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
365044010836	active site
365044010837	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
365044010838	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
365044010839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010840	catalytic residue [active]
365044010841	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
365044010842	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
365044010843	substrate binding site [chemical binding]; other site
365044010844	active site
365044010845	catalytic residues [active]
365044010846	heterodimer interface [polypeptide binding]; other site
365044010847	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
365044010848	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
365044010849	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
365044010850	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
365044010851	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
365044010852	dimer interface [polypeptide binding]; other site
365044010853	putative anticodon binding site; other site
365044010854	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
365044010855	motif 1; other site
365044010856	active site
365044010857	motif 2; other site
365044010858	motif 3; other site
365044010859	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
365044010860	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
365044010861	active site
365044010862	nucleophile elbow; other site
365044010863	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
365044010864	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
365044010865	beta-hexosaminidase; Provisional; Region: PRK05337
365044010866	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
365044010867	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
365044010868	active site
365044010869	hydrophilic channel; other site
365044010870	dimerization interface [polypeptide binding]; other site
365044010871	catalytic residues [active]
365044010872	active site lid [active]
365044010873	Recombination protein O N terminal; Region: RecO_N; pfam11967
365044010874	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
365044010875	Recombination protein O C terminal; Region: RecO_C; pfam02565
365044010876	GTPase Era; Reviewed; Region: era; PRK00089
365044010877	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
365044010878	G1 box; other site
365044010879	GTP/Mg2+ binding site [chemical binding]; other site
365044010880	Switch I region; other site
365044010881	G2 box; other site
365044010882	Switch II region; other site
365044010883	G3 box; other site
365044010884	G4 box; other site
365044010885	G5 box; other site
365044010886	KH domain; Region: KH_2; pfam07650
365044010887	ribonuclease III; Reviewed; Region: rnc; PRK00102
365044010888	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
365044010889	dimerization interface [polypeptide binding]; other site
365044010890	active site
365044010891	metal binding site [ion binding]; metal-binding site
365044010892	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
365044010893	dsRNA binding site [nucleotide binding]; other site
365044010894	signal peptidase I; Provisional; Region: PRK10861
365044010895	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
365044010896	Catalytic site [active]
365044010897	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
365044010898	GTP-binding protein LepA; Provisional; Region: PRK05433
365044010899	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
365044010900	G1 box; other site
365044010901	putative GEF interaction site [polypeptide binding]; other site
365044010902	GTP/Mg2+ binding site [chemical binding]; other site
365044010903	Switch I region; other site
365044010904	G2 box; other site
365044010905	G3 box; other site
365044010906	Switch II region; other site
365044010907	G4 box; other site
365044010908	G5 box; other site
365044010909	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
365044010910	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
365044010911	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
365044010912	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
365044010913	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
365044010914	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044010915	protein binding site [polypeptide binding]; other site
365044010916	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044010917	protein binding site [polypeptide binding]; other site
365044010918	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
365044010919	anti-sigma E factor; Provisional; Region: rseB; PRK09455
365044010920	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
365044010921	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
365044010922	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044010923	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044010924	DNA binding residues [nucleotide binding]
365044010925	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
365044010926	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365044010927	dimer interface [polypeptide binding]; other site
365044010928	active site
365044010929	acyl carrier protein; Provisional; Region: acpP; PRK00982
365044010930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010931	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
365044010932	NAD(P) binding site [chemical binding]; other site
365044010933	active site
365044010934	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
365044010935	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
365044010936	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
365044010937	BNR repeat-like domain; Region: BNR_2; pfam13088
365044010938	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
365044010939	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
365044010940	dimer interface [polypeptide binding]; other site
365044010941	active site
365044010942	CoA binding pocket [chemical binding]; other site
365044010943	putative phosphate acyltransferase; Provisional; Region: PRK05331
365044010944	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
365044010945	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
365044010946	Maf-like protein; Region: Maf; pfam02545
365044010947	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
365044010948	active site
365044010949	dimer interface [polypeptide binding]; other site
365044010950	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
365044010951	putative SAM binding site [chemical binding]; other site
365044010952	homodimer interface [polypeptide binding]; other site
365044010953	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
365044010954	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
365044010955	tandem repeat interface [polypeptide binding]; other site
365044010956	oligomer interface [polypeptide binding]; other site
365044010957	active site residues [active]
365044010958	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
365044010959	iron-sulfur cluster [ion binding]; other site
365044010960	[2Fe-2S] cluster binding site [ion binding]; other site
365044010961	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
365044010962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044010963	motif II; other site
365044010964	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
365044010965	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044010966	RNA binding surface [nucleotide binding]; other site
365044010967	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365044010968	active site
365044010969	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
365044010970	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
365044010971	homodimer interface [polypeptide binding]; other site
365044010972	oligonucleotide binding site [chemical binding]; other site
365044010973	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
365044010974	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
365044010975	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
365044010976	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
365044010977	active site
365044010978	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
365044010979	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
365044010980	domain interfaces; other site
365044010981	active site
365044010982	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
365044010983	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
365044010984	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
365044010985	Putative glucoamylase; Region: Glycoamylase; pfam10091
365044010986	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
365044010987	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
365044010988	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
365044010989	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
365044010990	putative active site [active]
365044010991	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365044010992	Domain of unknown function DUF20; Region: UPF0118; pfam01594
365044010993	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365044010994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044010995	active site
365044010996	phosphorylation site [posttranslational modification]
365044010997	intermolecular recognition site; other site
365044010998	dimerization interface [polypeptide binding]; other site
365044010999	LytTr DNA-binding domain; Region: LytTR; smart00850
365044011000	Histidine kinase; Region: His_kinase; pfam06580
365044011001	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365044011002	argininosuccinate lyase; Provisional; Region: PRK00855
365044011003	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
365044011004	active sites [active]
365044011005	tetramer interface [polypeptide binding]; other site
365044011006	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
365044011007	Protein of unknown function (DUF497); Region: DUF497; pfam04365
365044011008	Phasin protein; Region: Phasin_2; pfam09361
365044011009	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
365044011010	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
365044011011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011012	Walker A motif; other site
365044011013	ATP binding site [chemical binding]; other site
365044011014	Walker B motif; other site
365044011015	arginine finger; other site
365044011016	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
365044011017	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
365044011018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011019	active site
365044011020	phosphorylation site [posttranslational modification]
365044011021	intermolecular recognition site; other site
365044011022	dimerization interface [polypeptide binding]; other site
365044011023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044011024	DNA binding site [nucleotide binding]
365044011025	HAMP domain; Region: HAMP; pfam00672
365044011026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011027	dimer interface [polypeptide binding]; other site
365044011028	phosphorylation site [posttranslational modification]
365044011029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011030	ATP binding site [chemical binding]; other site
365044011031	G-X-G motif; other site
365044011032	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
365044011033	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
365044011034	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044011035	protein binding site [polypeptide binding]; other site
365044011036	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044011037	protein binding site [polypeptide binding]; other site
365044011038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044011039	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044011040	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044011041	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
365044011042	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
365044011043	MG2 domain; Region: A2M_N; pfam01835
365044011044	Alpha-2-macroglobulin family; Region: A2M; pfam00207
365044011045	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
365044011046	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
365044011047	Bacterial sugar transferase; Region: Bac_transf; pfam02397
365044011048	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
365044011049	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
365044011050	NAD(P) binding site [chemical binding]; other site
365044011051	homodimer interface [polypeptide binding]; other site
365044011052	substrate binding site [chemical binding]; other site
365044011053	active site
365044011054	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
365044011055	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365044011056	inhibitor-cofactor binding pocket; inhibition site
365044011057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011058	catalytic residue [active]
365044011059	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044011060	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
365044011061	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
365044011062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044011063	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
365044011064	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
365044011065	Ligand Binding Site [chemical binding]; other site
365044011066	imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033
365044011067	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
365044011068	substrate binding site [chemical binding]; other site
365044011069	glutamase interaction surface [polypeptide binding]; other site
365044011070	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
365044011071	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
365044011072	putative active site [active]
365044011073	oxyanion strand; other site
365044011074	catalytic triad [active]
365044011075	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
365044011076	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
365044011077	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
365044011078	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365044011079	inhibitor-cofactor binding pocket; inhibition site
365044011080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011081	catalytic residue [active]
365044011082	putative trimer interface [polypeptide binding]; other site
365044011083	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
365044011084	putative CoA binding site [chemical binding]; other site
365044011085	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
365044011086	putative trimer interface [polypeptide binding]; other site
365044011087	putative active site [active]
365044011088	putative substrate binding site [chemical binding]; other site
365044011089	putative CoA binding site [chemical binding]; other site
365044011090	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044011091	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
365044011092	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
365044011093	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
365044011094	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
365044011095	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
365044011096	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
365044011097	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
365044011098	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
365044011099	Mg++ binding site [ion binding]; other site
365044011100	putative catalytic motif [active]
365044011101	tyrosine kinase; Provisional; Region: PRK11519
365044011102	Chain length determinant protein; Region: Wzz; pfam02706
365044011103	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
365044011104	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
365044011105	polysaccharide export protein Wza; Provisional; Region: PRK15078
365044011106	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
365044011107	SLBB domain; Region: SLBB; pfam10531
365044011108	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
365044011109	transcriptional activator RfaH; Region: RfaH; TIGR01955
365044011110	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
365044011111	heterodimer interface [polypeptide binding]; other site
365044011112	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
365044011113	Sel1 repeat; Region: Sel1; cl02723
365044011114	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
365044011115	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365044011116	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
365044011117	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
365044011118	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
365044011119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011120	Walker A motif; other site
365044011121	ATP binding site [chemical binding]; other site
365044011122	Walker B motif; other site
365044011123	arginine finger; other site
365044011124	tellurium resistance terB-like protein; Region: terB_like; cl11965
365044011125	metal binding site [ion binding]; metal-binding site
365044011126	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
365044011127	Transglycosylase; Region: Transgly; pfam00912
365044011128	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
365044011129	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
365044011130	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044011131	MarR family; Region: MarR; pfam01047
365044011132	salicylate hydroxylase; Provisional; Region: PRK08163
365044011133	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
365044011134	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
365044011135	Cupin domain; Region: Cupin_2; pfam07883
365044011136	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044011137	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
365044011138	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
365044011139	maleylacetoacetate isomerase; Region: maiA; TIGR01262
365044011140	C-terminal domain interface [polypeptide binding]; other site
365044011141	GSH binding site (G-site) [chemical binding]; other site
365044011142	putative dimer interface [polypeptide binding]; other site
365044011143	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
365044011144	dimer interface [polypeptide binding]; other site
365044011145	N-terminal domain interface [polypeptide binding]; other site
365044011146	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
365044011147	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044011148	Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236
365044011149	AAA domain; Region: AAA_14; pfam13173
365044011150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044011151	Probable transposase; Region: OrfB_IS605; pfam01385
365044011152	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044011153	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044011154	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365044011155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044011156	Walker A motif; other site
365044011157	ATP binding site [chemical binding]; other site
365044011158	Walker B motif; other site
365044011159	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044011160	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365044011161	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
365044011162	Walker A motif; other site
365044011163	ATP binding site [chemical binding]; other site
365044011164	Walker B motif; other site
365044011165	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
365044011166	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
365044011167	active site
365044011168	substrate binding site [chemical binding]; other site
365044011169	FMN binding site [chemical binding]; other site
365044011170	putative catalytic residues [active]
365044011171	Cytochrome c; Region: Cytochrom_C; pfam00034
365044011172	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
365044011173	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
365044011174	SPFH domain / Band 7 family; Region: Band_7; pfam01145
365044011175	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
365044011176	active site
365044011177	DNA polymerase IV; Validated; Region: PRK02406
365044011178	DNA binding site [nucleotide binding]
365044011179	PAS domain; Region: PAS_9; pfam13426
365044011180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044011181	putative active site [active]
365044011182	heme pocket [chemical binding]; other site
365044011183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011184	dimer interface [polypeptide binding]; other site
365044011185	phosphorylation site [posttranslational modification]
365044011186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011187	ATP binding site [chemical binding]; other site
365044011188	Mg2+ binding site [ion binding]; other site
365044011189	G-X-G motif; other site
365044011190	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
365044011191	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044011192	apolar tunnel; other site
365044011193	heme binding site [chemical binding]; other site
365044011194	dimerization interface [polypeptide binding]; other site
365044011195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
365044011196	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
365044011197	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
365044011198	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
365044011199	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
365044011200	TAP-like protein; Region: Abhydrolase_4; pfam08386
365044011201	hypothetical protein; Validated; Region: PRK02101
365044011202	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044011203	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044011204	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044011205	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044011206	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
365044011207	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044011208	active site
365044011209	HIGH motif; other site
365044011210	nucleotide binding site [chemical binding]; other site
365044011211	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
365044011212	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
365044011213	active site
365044011214	KMSKS motif; other site
365044011215	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
365044011216	tRNA binding surface [nucleotide binding]; other site
365044011217	anticodon binding site; other site
365044011218	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
365044011219	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
365044011220	CPxP  motif; other site
365044011221	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044011222	nudix motif; other site
365044011223	cysteine synthase B; Region: cysM; TIGR01138
365044011224	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365044011225	dimer interface [polypeptide binding]; other site
365044011226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011227	catalytic residue [active]
365044011228	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044011229	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044011230	Probable transposase; Region: OrfB_IS605; pfam01385
365044011231	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044011232	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
365044011233	active site
365044011234	GDP-Mannose binding site [chemical binding]; other site
365044011235	modified nudix motif
365044011236	dimer interface [polypeptide binding]; other site
365044011237	metal binding site [ion binding]; metal-binding site
365044011238	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
365044011239	active site
365044011240	tetramer interface; other site
365044011241	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
365044011242	Bacterial sugar transferase; Region: Bac_transf; pfam02397
365044011243	putative glycosyl transferase; Provisional; Region: PRK10307
365044011244	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
365044011245	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
365044011246	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
365044011247	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044011248	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
365044011249	putative metal binding site; other site
365044011250	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
365044011251	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
365044011252	putative trimer interface [polypeptide binding]; other site
365044011253	putative active site [active]
365044011254	putative substrate binding site [chemical binding]; other site
365044011255	putative CoA binding site [chemical binding]; other site
365044011256	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044011257	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
365044011258	putative ADP-binding pocket [chemical binding]; other site
365044011259	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
365044011260	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
365044011261	putative trimer interface [polypeptide binding]; other site
365044011262	putative CoA binding site [chemical binding]; other site
365044011263	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044011264	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
365044011265	metal-binding site
365044011266	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044011267	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365044011268	active site
365044011269	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
365044011270	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
365044011271	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
365044011272	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
365044011273	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
365044011274	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
365044011275	NADP-binding site; other site
365044011276	homotetramer interface [polypeptide binding]; other site
365044011277	substrate binding site [chemical binding]; other site
365044011278	homodimer interface [polypeptide binding]; other site
365044011279	active site
365044011280	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
365044011281	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
365044011282	NADP binding site [chemical binding]; other site
365044011283	active site
365044011284	putative substrate binding site [chemical binding]; other site
365044011285	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
365044011286	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
365044011287	Substrate binding site; other site
365044011288	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
365044011289	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
365044011290	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
365044011291	catalytic residue [active]
365044011292	putative FPP diphosphate  binding site; other site
365044011293	putative FPP binding hydrophobic cleft; other site
365044011294	dimer interface [polypeptide binding]; other site
365044011295	putative IPP diphosphate binding site; other site
365044011296	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
365044011297	Chain length determinant protein; Region: Wzz; pfam02706
365044011298	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
365044011299	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044011300	P loop; other site
365044011301	Nucleotide binding site [chemical binding]; other site
365044011302	DTAP/Switch II; other site
365044011303	Switch I; other site
365044011304	Low molecular weight phosphatase family; Region: LMWPc; cd00115
365044011305	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
365044011306	active site
365044011307	polysaccharide export protein Wza; Provisional; Region: PRK15078
365044011308	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
365044011309	SLBB domain; Region: SLBB; pfam10531
365044011310	SLBB domain; Region: SLBB; pfam10531
365044011311	transcriptional activator RfaH; Region: RfaH; TIGR01955
365044011312	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
365044011313	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
365044011314	Domain of unknown function DUF21; Region: DUF21; pfam01595
365044011315	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
365044011316	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365044011317	Transporter associated domain; Region: CorC_HlyC; smart01091
365044011318	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
365044011319	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
365044011320	active site
365044011321	metal binding site [ion binding]; metal-binding site
365044011322	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
365044011323	helicase 45; Provisional; Region: PTZ00424
365044011324	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044011325	ATP binding site [chemical binding]; other site
365044011326	Mg++ binding site [ion binding]; other site
365044011327	motif III; other site
365044011328	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044011329	nucleotide binding region [chemical binding]; other site
365044011330	ATP-binding site [chemical binding]; other site
365044011331	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044011332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044011333	NAD(P) binding site [chemical binding]; other site
365044011334	active site
365044011335	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
365044011336	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044011337	catalytic loop [active]
365044011338	iron binding site [ion binding]; other site
365044011339	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
365044011340	FAD binding pocket [chemical binding]; other site
365044011341	FAD binding motif [chemical binding]; other site
365044011342	phosphate binding motif [ion binding]; other site
365044011343	beta-alpha-beta structure motif; other site
365044011344	NAD binding pocket [chemical binding]; other site
365044011345	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044011346	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044011347	Walker A/P-loop; other site
365044011348	ATP binding site [chemical binding]; other site
365044011349	Q-loop/lid; other site
365044011350	ABC transporter signature motif; other site
365044011351	Walker B; other site
365044011352	D-loop; other site
365044011353	H-loop/switch region; other site
365044011354	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044011355	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044011356	Walker A/P-loop; other site
365044011357	ATP binding site [chemical binding]; other site
365044011358	Q-loop/lid; other site
365044011359	ABC transporter signature motif; other site
365044011360	Walker B; other site
365044011361	D-loop; other site
365044011362	H-loop/switch region; other site
365044011363	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044011364	TM-ABC transporter signature motif; other site
365044011365	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044011366	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044011367	TM-ABC transporter signature motif; other site
365044011368	recombination factor protein RarA; Reviewed; Region: PRK13342
365044011369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011370	Walker A motif; other site
365044011371	ATP binding site [chemical binding]; other site
365044011372	Walker B motif; other site
365044011373	arginine finger; other site
365044011374	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
365044011375	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
365044011376	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
365044011377	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
365044011378	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
365044011379	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
365044011380	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044011381	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044011382	ligand binding site [chemical binding]; other site
365044011383	flexible hinge region; other site
365044011384	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044011385	non-specific DNA interactions [nucleotide binding]; other site
365044011386	DNA binding site [nucleotide binding]
365044011387	sequence specific DNA binding site [nucleotide binding]; other site
365044011388	putative cAMP binding site [chemical binding]; other site
365044011389	thioredoxin reductase; Provisional; Region: PRK10262
365044011390	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044011391	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044011392	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
365044011393	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
365044011394	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
365044011395	Fatty acid desaturase; Region: FA_desaturase; pfam00487
365044011396	Di-iron ligands [ion binding]; other site
365044011397	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
365044011398	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
365044011399	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
365044011400	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
365044011401	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
365044011402	G1 box; other site
365044011403	putative GEF interaction site [polypeptide binding]; other site
365044011404	GTP/Mg2+ binding site [chemical binding]; other site
365044011405	Switch I region; other site
365044011406	G2 box; other site
365044011407	G3 box; other site
365044011408	Switch II region; other site
365044011409	G4 box; other site
365044011410	G5 box; other site
365044011411	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
365044011412	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
365044011413	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044011414	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044011415	putative DNA binding site [nucleotide binding]; other site
365044011416	putative Zn2+ binding site [ion binding]; other site
365044011417	AsnC family; Region: AsnC_trans_reg; pfam01037
365044011418	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
365044011419	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
365044011420	active site
365044011421	substrate binding site [chemical binding]; other site
365044011422	cosubstrate binding site; other site
365044011423	catalytic site [active]
365044011424	hypothetical protein; Provisional; Region: PRK11239
365044011425	Protein of unknown function, DUF480; Region: DUF480; pfam04337
365044011426	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
365044011427	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044011428	active site
365044011429	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
365044011430	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
365044011431	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
365044011432	active site
365044011433	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
365044011434	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
365044011435	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044011436	active site
365044011437	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
365044011438	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
365044011439	active site
365044011440	Riboflavin kinase; Region: Flavokinase; smart00904
365044011441	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
365044011442	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044011443	active site
365044011444	HIGH motif; other site
365044011445	nucleotide binding site [chemical binding]; other site
365044011446	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
365044011447	active site
365044011448	KMSKS motif; other site
365044011449	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
365044011450	tRNA binding surface [nucleotide binding]; other site
365044011451	anticodon binding site; other site
365044011452	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
365044011453	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
365044011454	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
365044011455	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
365044011456	PhoU domain; Region: PhoU; pfam01895
365044011457	PhoU domain; Region: PhoU; pfam01895
365044011458	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
365044011459	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
365044011460	NADP binding site [chemical binding]; other site
365044011461	dimer interface [polypeptide binding]; other site
365044011462	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
365044011463	EamA-like transporter family; Region: EamA; pfam00892
365044011464	EamA-like transporter family; Region: EamA; pfam00892
365044011465	short chain dehydrogenase; Provisional; Region: PRK08339
365044011466	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
365044011467	putative NAD(P) binding site [chemical binding]; other site
365044011468	putative active site [active]
365044011469	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
365044011470	EamA-like transporter family; Region: EamA; pfam00892
365044011471	EamA-like transporter family; Region: EamA; pfam00892
365044011472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
365044011473	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
365044011474	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044011475	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365044011476	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
365044011477	Walker A motif; other site
365044011478	ATP binding site [chemical binding]; other site
365044011479	Walker B motif; other site
365044011480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044011481	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044011482	active site
365044011483	Int/Topo IB signature motif; other site
365044011484	DNA binding site [nucleotide binding]
365044011485	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
365044011486	putative active site [active]
365044011487	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
365044011488	active site
365044011489	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
365044011490	MoxR-like ATPases [General function prediction only]; Region: COG0714
365044011491	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011492	Walker A motif; other site
365044011493	ATP binding site [chemical binding]; other site
365044011494	Walker B motif; other site
365044011495	arginine finger; other site
365044011496	Protein of unknown function DUF58; Region: DUF58; pfam01882
365044011497	von Willebrand factor type A domain; Region: VWA_2; pfam13519
365044011498	metal ion-dependent adhesion site (MIDAS); other site
365044011499	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
365044011500	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
365044011501	active site
365044011502	nucleophile elbow; other site
365044011503	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044011504	HSP70 interaction site [polypeptide binding]; other site
365044011505	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
365044011506	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044011507	Walker A/P-loop; other site
365044011508	ATP binding site [chemical binding]; other site
365044011509	Q-loop/lid; other site
365044011510	ABC transporter signature motif; other site
365044011511	Walker B; other site
365044011512	D-loop; other site
365044011513	H-loop/switch region; other site
365044011514	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
365044011515	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044011516	FtsX-like permease family; Region: FtsX; pfam02687
365044011517	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
365044011518	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
365044011519	DHH family; Region: DHH; pfam01368
365044011520	DHHA1 domain; Region: DHHA1; pfam02272
365044011521	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
365044011522	Tubulin like; Region: Tubulin_2; pfam13809
365044011523	Fic family protein [Function unknown]; Region: COG3177
365044011524	Fic/DOC family; Region: Fic; pfam02661
365044011525	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
365044011526	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365044011527	active site
365044011528	catalytic site [active]
365044011529	substrate binding site [chemical binding]; other site
365044011530	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
365044011531	HSP70 interaction site [polypeptide binding]; other site
365044011532	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
365044011533	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044011534	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044011535	ligand binding site [chemical binding]; other site
365044011536	flexible hinge region; other site
365044011537	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044011538	non-specific DNA interactions [nucleotide binding]; other site
365044011539	DNA binding site [nucleotide binding]
365044011540	sequence specific DNA binding site [nucleotide binding]; other site
365044011541	putative cAMP binding site [chemical binding]; other site
365044011542	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
365044011543	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365044011544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044011545	Walker A/P-loop; other site
365044011546	ATP binding site [chemical binding]; other site
365044011547	Q-loop/lid; other site
365044011548	ABC transporter signature motif; other site
365044011549	Walker B; other site
365044011550	D-loop; other site
365044011551	H-loop/switch region; other site
365044011552	TOBE domain; Region: TOBE_2; pfam08402
365044011553	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
365044011554	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
365044011555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011556	dimer interface [polypeptide binding]; other site
365044011557	conserved gate region; other site
365044011558	putative PBP binding loops; other site
365044011559	ABC-ATPase subunit interface; other site
365044011560	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
365044011561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011562	dimer interface [polypeptide binding]; other site
365044011563	conserved gate region; other site
365044011564	ABC-ATPase subunit interface; other site
365044011565	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044011566	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044011567	DNA-binding site [nucleotide binding]; DNA binding site
365044011568	FCD domain; Region: FCD; pfam07729
365044011569	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
365044011570	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
365044011571	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
365044011572	active site
365044011573	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
365044011574	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044011575	EamA-like transporter family; Region: EamA; pfam00892
365044011576	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
365044011577	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
365044011578	Peptidase family M50; Region: Peptidase_M50; pfam02163
365044011579	active site
365044011580	putative substrate binding region [chemical binding]; other site
365044011581	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
365044011582	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
365044011583	active site
365044011584	HIGH motif; other site
365044011585	dimer interface [polypeptide binding]; other site
365044011586	KMSKS motif; other site
365044011587	CsbD-like; Region: CsbD; pfam05532
365044011588	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044011589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011590	active site
365044011591	phosphorylation site [posttranslational modification]
365044011592	intermolecular recognition site; other site
365044011593	dimerization interface [polypeptide binding]; other site
365044011594	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044011595	DNA binding site [nucleotide binding]
365044011596	PAS domain; Region: PAS_9; pfam13426
365044011597	PAS fold; Region: PAS_4; pfam08448
365044011598	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044011599	putative active site [active]
365044011600	heme pocket [chemical binding]; other site
365044011601	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044011602	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011603	dimer interface [polypeptide binding]; other site
365044011604	phosphorylation site [posttranslational modification]
365044011605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011606	ATP binding site [chemical binding]; other site
365044011607	G-X-G motif; other site
365044011608	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044011609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011610	active site
365044011611	phosphorylation site [posttranslational modification]
365044011612	intermolecular recognition site; other site
365044011613	dimerization interface [polypeptide binding]; other site
365044011614	acyl-CoA synthetase; Validated; Region: PRK08162
365044011615	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
365044011616	acyl-activating enzyme (AAE) consensus motif; other site
365044011617	putative active site [active]
365044011618	AMP binding site [chemical binding]; other site
365044011619	putative CoA binding site [chemical binding]; other site
365044011620	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
365044011621	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
365044011622	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
365044011623	dimer interaction site [polypeptide binding]; other site
365044011624	substrate-binding tunnel; other site
365044011625	active site
365044011626	catalytic site [active]
365044011627	substrate binding site [chemical binding]; other site
365044011628	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
365044011629	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
365044011630	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044011631	active site
365044011632	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
365044011633	Protein of unknown function, DUF485; Region: DUF485; pfam04341
365044011634	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
365044011635	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
365044011636	Na binding site [ion binding]; other site
365044011637	portal vertex protein; Provisional; Region: Q; PHA02536
365044011638	Phage portal protein; Region: Phage_portal; pfam04860
365044011639	terminase ATPase subunit; Provisional; Region: P; PHA02535
365044011640	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
365044011641	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
365044011642	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
365044011643	capsid protein; Provisional; Region: N; PHA02538
365044011644	terminase endonuclease subunit; Provisional; Region: M; PHA02537
365044011645	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
365044011646	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
365044011647	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
365044011648	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
365044011649	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
365044011650	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
365044011651	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
365044011652	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
365044011653	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
365044011654	Baseplate J-like protein; Region: Baseplate_J; cl01294
365044011655	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
365044011656	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
365044011657	oxyanion hole [active]
365044011658	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
365044011659	active site
365044011660	catalytic triad [active]
365044011661	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
365044011662	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
365044011663	Phage Tail Collar Domain; Region: Collar; pfam07484
365044011664	major tail sheath protein; Provisional; Region: FI; PHA02560
365044011665	Phage tail tube protein FII; Region: Phage_tube; pfam04985
365044011666	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
365044011667	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
365044011668	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
365044011669	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
365044011670	tail protein; Provisional; Region: D; PHA02561
365044011671	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044011672	non-specific DNA binding site [nucleotide binding]; other site
365044011673	salt bridge; other site
365044011674	sequence-specific DNA binding site [nucleotide binding]; other site
365044011675	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
365044011676	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
365044011677	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044011678	active site
365044011679	metal binding site [ion binding]; metal-binding site
365044011680	interdomain interaction site; other site
365044011681	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
365044011682	WYL domain; Region: WYL; cl14852
365044011683	Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601
365044011684	Predicted transcriptional regulator [Transcription]; Region: COG2378
365044011685	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
365044011686	Helix-turn-helix domain; Region: HTH_36; pfam13730
365044011687	Protein of unknown function (DUF2528); Region: DUF2528; pfam10800
365044011688	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
365044011689	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
365044011690	integrase; Provisional; Region: PRK09692
365044011691	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
365044011692	active site
365044011693	Int/Topo IB signature motif; other site
365044011694	seryl-tRNA synthetase; Provisional; Region: PRK05431
365044011695	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
365044011696	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
365044011697	dimer interface [polypeptide binding]; other site
365044011698	active site
365044011699	motif 1; other site
365044011700	motif 2; other site
365044011701	motif 3; other site
365044011702	threonine dehydratase; Provisional; Region: PRK08246
365044011703	hypothetical protein; Provisional; Region: PRK06815
365044011704	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044011705	catalytic residue [active]
365044011706	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
365044011707	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
365044011708	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
365044011709	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
365044011710	hypothetical protein; Reviewed; Region: PRK00024
365044011711	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
365044011712	MPN+ (JAMM) motif; other site
365044011713	Zinc-binding site [ion binding]; other site
365044011714	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
365044011715	Smr domain; Region: Smr; pfam01713
365044011716	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044011717	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044011718	DNA binding residues [nucleotide binding]
365044011719	dimerization interface [polypeptide binding]; other site
365044011720	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
365044011721	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044011722	putative acyl-acceptor binding pocket; other site
365044011723	dihydroorotase; Provisional; Region: PRK07627
365044011724	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044011725	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
365044011726	active site
365044011727	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
365044011728	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
365044011729	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
365044011730	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
365044011731	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044011732	active site
365044011733	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
365044011734	hypothetical protein; Validated; Region: PRK00228
365044011735	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
365044011736	DNA photolyase; Region: DNA_photolyase; pfam00875
365044011737	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044011738	putative binding surface; other site
365044011739	active site
365044011740	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044011741	putative binding surface; other site
365044011742	active site
365044011743	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
365044011744	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044011745	putative binding surface; other site
365044011746	active site
365044011747	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
365044011748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011749	ATP binding site [chemical binding]; other site
365044011750	Mg2+ binding site [ion binding]; other site
365044011751	G-X-G motif; other site
365044011752	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
365044011753	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011755	active site
365044011756	phosphorylation site [posttranslational modification]
365044011757	intermolecular recognition site; other site
365044011758	dimerization interface [polypeptide binding]; other site
365044011759	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044011760	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
365044011761	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
365044011762	dimer interface [polypeptide binding]; other site
365044011763	putative CheW interface [polypeptide binding]; other site
365044011764	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
365044011765	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011767	active site
365044011768	phosphorylation site [posttranslational modification]
365044011769	intermolecular recognition site; other site
365044011770	dimerization interface [polypeptide binding]; other site
365044011771	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011773	active site
365044011774	phosphorylation site [posttranslational modification]
365044011775	intermolecular recognition site; other site
365044011776	dimerization interface [polypeptide binding]; other site
365044011777	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
365044011778	Rubredoxin; Region: Rubredoxin; pfam00301
365044011779	iron binding site [ion binding]; other site
365044011780	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
365044011781	substrate binding site [chemical binding]; other site
365044011782	ATP binding site [chemical binding]; other site
365044011783	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
365044011784	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044011785	inhibitor-cofactor binding pocket; inhibition site
365044011786	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011787	catalytic residue [active]
365044011788	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
365044011789	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
365044011790	purine monophosphate binding site [chemical binding]; other site
365044011791	dimer interface [polypeptide binding]; other site
365044011792	putative catalytic residues [active]
365044011793	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
365044011794	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
365044011795	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
365044011796	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
365044011797	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365044011798	FMN binding site [chemical binding]; other site
365044011799	active site
365044011800	catalytic residues [active]
365044011801	substrate binding site [chemical binding]; other site
365044011802	Predicted membrane protein [Function unknown]; Region: COG1238
365044011803	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044011804	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044011805	RNA binding surface [nucleotide binding]; other site
365044011806	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
365044011807	active site
365044011808	GTP-binding protein YchF; Reviewed; Region: PRK09601
365044011809	YchF GTPase; Region: YchF; cd01900
365044011810	G1 box; other site
365044011811	GTP/Mg2+ binding site [chemical binding]; other site
365044011812	Switch I region; other site
365044011813	G2 box; other site
365044011814	Switch II region; other site
365044011815	G3 box; other site
365044011816	G4 box; other site
365044011817	G5 box; other site
365044011818	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
365044011819	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
365044011820	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
365044011821	Sulfate transporter family; Region: Sulfate_transp; pfam00916
365044011822	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
365044011823	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
365044011824	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
365044011825	MOSC domain; Region: MOSC; pfam03473
365044011826	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
365044011827	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
365044011828	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
365044011829	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
365044011830	dimerization domain [polypeptide binding]; other site
365044011831	dimer interface [polypeptide binding]; other site
365044011832	catalytic residues [active]
365044011833	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
365044011834	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
365044011835	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
365044011836	protein binding site [polypeptide binding]; other site
365044011837	enoyl-CoA hydratase; Provisional; Region: PRK05862
365044011838	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044011839	substrate binding site [chemical binding]; other site
365044011840	oxyanion hole (OAH) forming residues; other site
365044011841	trimer interface [polypeptide binding]; other site
365044011842	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
365044011843	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
365044011844	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
365044011845	Flavoprotein; Region: Flavoprotein; pfam02441
365044011846	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
365044011847	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
365044011848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044011849	FeS/SAM binding site; other site
365044011850	TRAM domain; Region: TRAM; pfam01938
365044011851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044011852	HAMP domain; Region: HAMP; pfam00672
365044011853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011854	dimer interface [polypeptide binding]; other site
365044011855	phosphorylation site [posttranslational modification]
365044011856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011857	ATP binding site [chemical binding]; other site
365044011858	Mg2+ binding site [ion binding]; other site
365044011859	G-X-G motif; other site
365044011860	response regulator GlrR; Provisional; Region: PRK15115
365044011861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011862	active site
365044011863	phosphorylation site [posttranslational modification]
365044011864	intermolecular recognition site; other site
365044011865	dimerization interface [polypeptide binding]; other site
365044011866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011867	Walker A motif; other site
365044011868	ATP binding site [chemical binding]; other site
365044011869	Walker B motif; other site
365044011870	arginine finger; other site
365044011871	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
365044011872	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
365044011873	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
365044011874	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
365044011875	Ligand binding site; other site
365044011876	DXD motif; other site
365044011877	signal recognition particle protein; Provisional; Region: PRK10867
365044011878	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
365044011879	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
365044011880	GTP binding site [chemical binding]; other site
365044011881	Signal peptide binding domain; Region: SRP_SPB; pfam02978
365044011882	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
365044011883	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
365044011884	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044011885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011886	dimer interface [polypeptide binding]; other site
365044011887	phosphorylation site [posttranslational modification]
365044011888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011889	ATP binding site [chemical binding]; other site
365044011890	Mg2+ binding site [ion binding]; other site
365044011891	G-X-G motif; other site
365044011892	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044011893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011894	active site
365044011895	phosphorylation site [posttranslational modification]
365044011896	intermolecular recognition site; other site
365044011897	dimerization interface [polypeptide binding]; other site
365044011898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011899	Walker A motif; other site
365044011900	ATP binding site [chemical binding]; other site
365044011901	Walker B motif; other site
365044011902	arginine finger; other site
365044011903	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
365044011904	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
365044011905	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
365044011906	amidase catalytic site [active]
365044011907	Zn binding residues [ion binding]; other site
365044011908	substrate binding site [chemical binding]; other site
365044011909	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
365044011910	ATP cone domain; Region: ATP-cone; pfam03477
365044011911	ATP cone domain; Region: ATP-cone; pfam03477
365044011912	Class I ribonucleotide reductase; Region: RNR_I; cd01679
365044011913	active site
365044011914	dimer interface [polypeptide binding]; other site
365044011915	catalytic residues [active]
365044011916	effector binding site; other site
365044011917	R2 peptide binding site; other site
365044011918	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
365044011919	dimer interface [polypeptide binding]; other site
365044011920	putative radical transfer pathway; other site
365044011921	diiron center [ion binding]; other site
365044011922	tyrosyl radical; other site
365044011923	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044011924	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
365044011925	substrate binding site [chemical binding]; other site
365044011926	ATP binding site [chemical binding]; other site
365044011927	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
365044011928	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
365044011929	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
365044011930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044011931	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
365044011932	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044011933	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
365044011934	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
365044011935	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
365044011936	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044011937	carboxyltransferase (CT) interaction site; other site
365044011938	biotinylation site [posttranslational modification]; other site
365044011939	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044011940	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
365044011941	catalytic residues [active]
365044011942	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
365044011943	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365044011944	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011945	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044011946	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
365044011947	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
365044011948	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365044011949	protease TldD; Provisional; Region: tldD; PRK10735
365044011950	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
365044011951	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
365044011952	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044011953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044011954	Probable transposase; Region: OrfB_IS605; pfam01385
365044011955	DDE superfamily endonuclease; Region: DDE_5; cl17874
365044011956	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044011957	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044011958	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
365044011959	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
365044011960	RNB domain; Region: RNB; pfam00773
365044011961	TonB C terminal; Region: TonB_2; pfam13103
365044011962	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
365044011963	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044011964	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044011965	shikimate binding site; other site
365044011966	NAD(P) binding site [chemical binding]; other site
365044011967	Transglycosylase; Region: Transgly; cl17702
365044011968	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
365044011969	active site
365044011970	putative DNA-binding cleft [nucleotide binding]; other site
365044011971	dimer interface [polypeptide binding]; other site
365044011972	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
365044011973	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
365044011974	cell division protein FtsZ; Validated; Region: PRK09330
365044011975	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
365044011976	nucleotide binding site [chemical binding]; other site
365044011977	SulA interaction site; other site
365044011978	cell division protein FtsA; Region: ftsA; TIGR01174
365044011979	Cell division protein FtsA; Region: FtsA; smart00842
365044011980	Cell division protein FtsA; Region: FtsA; pfam14450
365044011981	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
365044011982	Cell division protein FtsQ; Region: FtsQ; pfam03799
365044011983	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
365044011984	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
365044011985	ATP-grasp domain; Region: ATP-grasp_4; cl17255
365044011986	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
365044011987	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365044011988	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011989	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044011990	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
365044011991	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
365044011992	active site
365044011993	homodimer interface [polypeptide binding]; other site
365044011994	cell division protein FtsW; Region: ftsW; TIGR02614
365044011995	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
365044011996	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011997	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
365044011998	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
365044011999	Mg++ binding site [ion binding]; other site
365044012000	putative catalytic motif [active]
365044012001	putative substrate binding site [chemical binding]; other site
365044012002	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
365044012003	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365044012004	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044012005	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044012006	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
365044012007	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044012008	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044012009	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
365044012010	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365044012011	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
365044012012	Cell division protein FtsL; Region: FtsL; pfam04999
365044012013	MraW methylase family; Region: Methyltransf_5; cl17771
365044012014	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
365044012015	cell division protein MraZ; Reviewed; Region: PRK00326
365044012016	MraZ protein; Region: MraZ; pfam02381
365044012017	MraZ protein; Region: MraZ; pfam02381
365044012018	STAS domain; Region: STAS_2; pfam13466
365044012019	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
365044012020	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
365044012021	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
365044012022	P-loop, Walker A motif; other site
365044012023	Base recognition motif; other site
365044012024	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
365044012025	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044012026	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044012027	DNA-binding site [nucleotide binding]; DNA binding site
365044012028	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044012029	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044012030	homodimer interface [polypeptide binding]; other site
365044012031	catalytic residue [active]
365044012032	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
365044012033	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
365044012034	putative RNA binding site [nucleotide binding]; other site
365044012035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012036	S-adenosylmethionine binding site [chemical binding]; other site
365044012037	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
365044012038	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044012039	active site
365044012040	DNA binding site [nucleotide binding]
365044012041	Int/Topo IB signature motif; other site
365044012042	Protein of unknown function, DUF484; Region: DUF484; cl17449
365044012043	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
365044012044	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
365044012045	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
365044012046	cell density-dependent motility repressor; Provisional; Region: PRK10082
365044012047	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044012048	LysR substrate binding domain; Region: LysR_substrate; pfam03466
365044012049	dimerization interface [polypeptide binding]; other site
365044012050	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365044012051	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
365044012052	inhibitor site; inhibition site
365044012053	active site
365044012054	dimer interface [polypeptide binding]; other site
365044012055	catalytic residue [active]
365044012056	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044012057	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
365044012058	classical (c) SDRs; Region: SDR_c; cd05233
365044012059	NAD(P) binding site [chemical binding]; other site
365044012060	active site
365044012061	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
365044012062	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
365044012063	putative active site pocket [active]
365044012064	metal binding site [ion binding]; metal-binding site
365044012065	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044012066	nudix motif; other site
365044012067	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044012068	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044012069	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044012070	substrate binding pocket [chemical binding]; other site
365044012071	membrane-bound complex binding site; other site
365044012072	hinge residues; other site
365044012073	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
365044012074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044012075	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
365044012076	putative dimerization interface [polypeptide binding]; other site
365044012077	Transcriptional regulator; Region: Rrf2; cl17282
365044012078	Rrf2 family protein; Region: rrf2_super; TIGR00738
365044012079	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
365044012080	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365044012081	dimer interface [polypeptide binding]; other site
365044012082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044012083	catalytic residue [active]
365044012084	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
365044012085	ProQ/FINO family; Region: ProQ; smart00945
365044012086	putative RNA binding sites [nucleotide binding]; other site
365044012087	heat shock protein HtpX; Provisional; Region: PRK05457
365044012088	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
365044012089	LabA_like proteins; Region: LabA_like/DUF88; cl10034
365044012090	putative metal binding site [ion binding]; other site
365044012091	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
365044012092	active site
365044012093	substrate binding pocket [chemical binding]; other site
365044012094	dimer interface [polypeptide binding]; other site
365044012095	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
365044012096	DctM-like transporters; Region: DctM; pfam06808
365044012097	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
365044012098	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044012099	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044012100	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044012101	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365044012102	Walker A/P-loop; other site
365044012103	ATP binding site [chemical binding]; other site
365044012104	Q-loop/lid; other site
365044012105	ABC transporter signature motif; other site
365044012106	Walker B; other site
365044012107	D-loop; other site
365044012108	H-loop/switch region; other site
365044012109	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365044012110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012111	dimer interface [polypeptide binding]; other site
365044012112	conserved gate region; other site
365044012113	putative PBP binding loops; other site
365044012114	ABC-ATPase subunit interface; other site
365044012115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012116	dimer interface [polypeptide binding]; other site
365044012117	conserved gate region; other site
365044012118	putative PBP binding loops; other site
365044012119	ABC-ATPase subunit interface; other site
365044012120	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
365044012121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044012122	substrate binding pocket [chemical binding]; other site
365044012123	membrane-bound complex binding site; other site
365044012124	hinge residues; other site
365044012125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044012126	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
365044012127	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044012128	dimerization interface [polypeptide binding]; other site
365044012129	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
365044012130	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
365044012131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044012132	Walker A/P-loop; other site
365044012133	ATP binding site [chemical binding]; other site
365044012134	Q-loop/lid; other site
365044012135	ABC transporter signature motif; other site
365044012136	Walker B; other site
365044012137	D-loop; other site
365044012138	H-loop/switch region; other site
365044012139	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
365044012140	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
365044012141	DNA binding residues [nucleotide binding]
365044012142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044012143	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
365044012144	MgtC family; Region: MgtC; pfam02308
365044012145	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
365044012146	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
365044012147	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
365044012148	putative NAD(P) binding site [chemical binding]; other site
365044012149	active site
365044012150	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044012151	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
365044012152	putative C-terminal domain interface [polypeptide binding]; other site
365044012153	putative GSH binding site (G-site) [chemical binding]; other site
365044012154	putative dimer interface [polypeptide binding]; other site
365044012155	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
365044012156	putative N-terminal domain interface [polypeptide binding]; other site
365044012157	putative dimer interface [polypeptide binding]; other site
365044012158	putative substrate binding pocket (H-site) [chemical binding]; other site
365044012159	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
365044012160	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
365044012161	active site
365044012162	NTP binding site [chemical binding]; other site
365044012163	metal binding triad [ion binding]; metal-binding site
365044012164	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
365044012165	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365044012166	Zn2+ binding site [ion binding]; other site
365044012167	Mg2+ binding site [ion binding]; other site
365044012168	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044012169	CoenzymeA binding site [chemical binding]; other site
365044012170	subunit interaction site [polypeptide binding]; other site
365044012171	PHB binding site; other site
365044012172	Phasin protein; Region: Phasin_2; pfam09361
365044012173	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
365044012174	PLD-like domain; Region: PLDc_2; pfam13091
365044012175	putative active site [active]
365044012176	catalytic site [active]
365044012177	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
365044012178	PLD-like domain; Region: PLDc_2; pfam13091
365044012179	putative active site [active]
365044012180	catalytic site [active]
365044012181	L-lactate permease; Region: Lactate_perm; cl00701
365044012182	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
365044012183	enoyl-CoA hydratase; Provisional; Region: PRK06688
365044012184	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044012185	substrate binding site [chemical binding]; other site
365044012186	oxyanion hole (OAH) forming residues; other site
365044012187	trimer interface [polypeptide binding]; other site
365044012188	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
365044012189	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044012190	dimer interface [polypeptide binding]; other site
365044012191	active site
365044012192	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044012193	CoenzymeA binding site [chemical binding]; other site
365044012194	subunit interaction site [polypeptide binding]; other site
365044012195	PHB binding site; other site
365044012196	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
365044012197	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
365044012198	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044012199	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044012200	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044012201	substrate binding site [chemical binding]; other site
365044012202	oxyanion hole (OAH) forming residues; other site
365044012203	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
365044012204	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
365044012205	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044012206	active site
365044012207	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
365044012208	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044012209	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044012210	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
365044012211	feedback inhibition sensing region; other site
365044012212	homohexameric interface [polypeptide binding]; other site
365044012213	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
365044012214	nucleotide binding site [chemical binding]; other site
365044012215	N-acetyl-L-glutamate binding site [chemical binding]; other site
365044012216	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
365044012217	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
365044012218	NAD(P) binding site [chemical binding]; other site
365044012219	homodimer interface [polypeptide binding]; other site
365044012220	substrate binding site [chemical binding]; other site
365044012221	active site
365044012222	Bacterial sugar transferase; Region: Bac_transf; pfam02397
365044012223	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044012224	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
365044012225	putative NAD(P) binding site [chemical binding]; other site
365044012226	active site
365044012227	putative substrate binding site [chemical binding]; other site
365044012228	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044012229	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
365044012230	putative ADP-binding pocket [chemical binding]; other site
365044012231	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044012232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044012233	NAD(P) binding site [chemical binding]; other site
365044012234	active site
365044012235	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044012236	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
365044012237	Probable Catalytic site; other site
365044012238	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
365044012239	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
365044012240	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
365044012241	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
365044012242	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
365044012243	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
365044012244	substrate binding site; other site
365044012245	tetramer interface; other site
365044012246	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
365044012247	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
365044012248	NADP binding site [chemical binding]; other site
365044012249	active site
365044012250	putative substrate binding site [chemical binding]; other site
365044012251	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
365044012252	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
365044012253	NAD binding site [chemical binding]; other site
365044012254	substrate binding site [chemical binding]; other site
365044012255	homodimer interface [polypeptide binding]; other site
365044012256	active site
365044012257	Chain length determinant protein; Region: Wzz; cl15801
365044012258	H-NS histone family; Region: Histone_HNS; pfam00816
365044012259	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
365044012260	short chain dehydrogenase; Provisional; Region: PRK07201
365044012261	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
365044012262	putative NAD(P) binding site [chemical binding]; other site
365044012263	active site
365044012264	putative substrate binding site [chemical binding]; other site
365044012265	classical (c) SDRs; Region: SDR_c; cd05233
365044012266	NAD(P) binding site [chemical binding]; other site
365044012267	active site
365044012268	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
365044012269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044012270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044012271	Bacterial transcriptional repressor; Region: TetR; pfam13972
365044012272	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
365044012273	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
365044012274	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
365044012275	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
365044012276	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
365044012277	PAS domain S-box; Region: sensory_box; TIGR00229
365044012278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044012279	putative active site [active]
365044012280	heme pocket [chemical binding]; other site
365044012281	PAS domain S-box; Region: sensory_box; TIGR00229
365044012282	PAS domain; Region: PAS; smart00091
365044012283	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044012284	GAF domain; Region: GAF; pfam01590
365044012285	PAS domain S-box; Region: sensory_box; TIGR00229
365044012286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044012287	putative active site [active]
365044012288	heme pocket [chemical binding]; other site
365044012289	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012290	dimer interface [polypeptide binding]; other site
365044012291	phosphorylation site [posttranslational modification]
365044012292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012293	ATP binding site [chemical binding]; other site
365044012294	Mg2+ binding site [ion binding]; other site
365044012295	G-X-G motif; other site
365044012296	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
365044012297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044012298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044012299	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044012300	dimerization interface [polypeptide binding]; other site
365044012301	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044012302	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044012303	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044012304	active site
365044012305	catalytic residues [active]
365044012306	metal binding site [ion binding]; metal-binding site
365044012307	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
365044012308	dimer interface [polypeptide binding]; other site
365044012309	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044012310	metal binding site [ion binding]; metal-binding site
365044012311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044012312	Acyl CoA binding protein; Region: ACBP; pfam00887
365044012313	acyl-CoA binding pocket [chemical binding]; other site
365044012314	CoA binding site [chemical binding]; other site
365044012315	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
365044012316	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
365044012317	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
365044012318	pantothenate kinase; Reviewed; Region: PRK13329
365044012319	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044012320	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012321	DNA binding residues [nucleotide binding]
365044012322	dimerization interface [polypeptide binding]; other site
365044012323	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044012324	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
365044012325	dimer interface [polypeptide binding]; other site
365044012326	phosphorylation site [posttranslational modification]
365044012327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012328	ATP binding site [chemical binding]; other site
365044012329	Mg2+ binding site [ion binding]; other site
365044012330	G-X-G motif; other site
365044012331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
365044012332	active site
365044012333	phosphorylation site [posttranslational modification]
365044012334	intermolecular recognition site; other site
365044012335	dimerization interface [polypeptide binding]; other site
365044012336	hypothetical protein; Provisional; Region: PRK07179
365044012337	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
365044012338	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044012339	catalytic residue [active]
365044012340	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044012341	active site residue [active]
365044012342	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
365044012343	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044012344	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044012345	Walker A/P-loop; other site
365044012346	ATP binding site [chemical binding]; other site
365044012347	Q-loop/lid; other site
365044012348	ABC transporter signature motif; other site
365044012349	Walker B; other site
365044012350	D-loop; other site
365044012351	H-loop/switch region; other site
365044012352	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044012353	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044012354	TM-ABC transporter signature motif; other site
365044012355	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044012356	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044012357	Walker A/P-loop; other site
365044012358	ATP binding site [chemical binding]; other site
365044012359	Q-loop/lid; other site
365044012360	ABC transporter signature motif; other site
365044012361	Walker B; other site
365044012362	D-loop; other site
365044012363	H-loop/switch region; other site
365044012364	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044012365	TM-ABC transporter signature motif; other site
365044012366	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012367	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
365044012368	putative ligand binding site [chemical binding]; other site
365044012369	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
365044012370	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
365044012371	Histidine kinase; Region: HisKA_3; pfam07730
365044012372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012373	ATP binding site [chemical binding]; other site
365044012374	Mg2+ binding site [ion binding]; other site
365044012375	G-X-G motif; other site
365044012376	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044012377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012378	active site
365044012379	phosphorylation site [posttranslational modification]
365044012380	intermolecular recognition site; other site
365044012381	dimerization interface [polypeptide binding]; other site
365044012382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012383	DNA binding residues [nucleotide binding]
365044012384	dimerization interface [polypeptide binding]; other site
365044012385	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
365044012386	B12 binding site [chemical binding]; other site
365044012387	cobalt ligand [ion binding]; other site
365044012388	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
365044012389	Walker A; other site
365044012390	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
365044012391	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044012392	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044012393	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044012394	Walker A/P-loop; other site
365044012395	ATP binding site [chemical binding]; other site
365044012396	Q-loop/lid; other site
365044012397	ABC transporter signature motif; other site
365044012398	Walker B; other site
365044012399	D-loop; other site
365044012400	H-loop/switch region; other site
365044012401	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044012402	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044012403	Walker A/P-loop; other site
365044012404	ATP binding site [chemical binding]; other site
365044012405	Q-loop/lid; other site
365044012406	ABC transporter signature motif; other site
365044012407	Walker B; other site
365044012408	D-loop; other site
365044012409	H-loop/switch region; other site
365044012410	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012411	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
365044012412	putative ligand binding site [chemical binding]; other site
365044012413	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044012414	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044012415	TM-ABC transporter signature motif; other site
365044012416	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044012417	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044012418	TM-ABC transporter signature motif; other site
365044012419	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044012420	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044012421	trimer interface [polypeptide binding]; other site
365044012422	eyelet of channel; other site
365044012423	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044012424	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365044012425	Walker A/P-loop; other site
365044012426	ATP binding site [chemical binding]; other site
365044012427	Q-loop/lid; other site
365044012428	ABC transporter signature motif; other site
365044012429	Walker B; other site
365044012430	D-loop; other site
365044012431	H-loop/switch region; other site
365044012432	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044012433	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044012434	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365044012435	Walker A/P-loop; other site
365044012436	ATP binding site [chemical binding]; other site
365044012437	Q-loop/lid; other site
365044012438	ABC transporter signature motif; other site
365044012439	Walker B; other site
365044012440	D-loop; other site
365044012441	H-loop/switch region; other site
365044012442	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044012443	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
365044012444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012445	dimer interface [polypeptide binding]; other site
365044012446	conserved gate region; other site
365044012447	ABC-ATPase subunit interface; other site
365044012448	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
365044012449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012450	dimer interface [polypeptide binding]; other site
365044012451	conserved gate region; other site
365044012452	putative PBP binding loops; other site
365044012453	ABC-ATPase subunit interface; other site
365044012454	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
365044012455	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
365044012456	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
365044012457	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
365044012458	putative active site pocket [active]
365044012459	metal binding site [ion binding]; metal-binding site
365044012460	Transcriptional regulators [Transcription]; Region: FadR; COG2186
365044012461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044012462	DNA-binding site [nucleotide binding]; DNA binding site
365044012463	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
365044012464	RloB-like protein; Region: RloB; pfam13707
365044012465	Predicted ATPases [General function prediction only]; Region: COG1106
365044012466	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
365044012467	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044012468	ATP binding site [chemical binding]; other site
365044012469	Mg++ binding site [ion binding]; other site
365044012470	motif III; other site
365044012471	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044012472	nucleotide binding region [chemical binding]; other site
365044012473	ATP-binding site [chemical binding]; other site
365044012474	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
365044012475	putative RNA binding site [nucleotide binding]; other site
365044012476	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
365044012477	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
365044012478	active site
365044012479	glutathione reductase; Validated; Region: PRK06116
365044012480	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044012481	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044012482	AMP nucleosidase; Provisional; Region: PRK08292
365044012483	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
365044012484	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
365044012485	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044012486	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044012487	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044012488	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044012489	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044012490	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
365044012491	Walker A/P-loop; other site
365044012492	ATP binding site [chemical binding]; other site
365044012493	Q-loop/lid; other site
365044012494	ABC transporter signature motif; other site
365044012495	Walker B; other site
365044012496	D-loop; other site
365044012497	H-loop/switch region; other site
365044012498	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044012499	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365044012500	FtsX-like permease family; Region: FtsX; pfam02687
365044012501	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
365044012502	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
365044012503	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
365044012504	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044012505	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
365044012506	6-phosphofructokinase; Provisional; Region: PRK14072
365044012507	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
365044012508	active site
365044012509	ADP/pyrophosphate binding site [chemical binding]; other site
365044012510	dimerization interface [polypeptide binding]; other site
365044012511	allosteric effector site; other site
365044012512	fructose-1,6-bisphosphate binding site; other site
365044012513	Fic family protein [Function unknown]; Region: COG3177
365044012514	Fic/DOC family; Region: Fic; pfam02661
365044012515	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
365044012516	Double zinc ribbon; Region: DZR; pfam12773
365044012517	hypothetical protein; Provisional; Region: PRK12378
365044012518	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
365044012519	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
365044012520	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
365044012521	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044012522	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044012523	motif II; other site
365044012524	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365044012525	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
365044012526	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
365044012527	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
365044012528	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
365044012529	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
365044012530	NAD binding site [chemical binding]; other site
365044012531	homotetramer interface [polypeptide binding]; other site
365044012532	homodimer interface [polypeptide binding]; other site
365044012533	substrate binding site [chemical binding]; other site
365044012534	active site
365044012535	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
365044012536	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
365044012537	dimer interaction site [polypeptide binding]; other site
365044012538	substrate-binding tunnel; other site
365044012539	active site
365044012540	catalytic site [active]
365044012541	substrate binding site [chemical binding]; other site
365044012542	phosphate acetyltransferase; Provisional; Region: PRK11890
365044012543	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
365044012544	propionate/acetate kinase; Provisional; Region: PRK12379
365044012545	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
365044012546	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365044012547	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
365044012548	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
365044012549	ATP-grasp domain; Region: ATP-grasp; pfam02222
365044012550	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
365044012551	metal coordination site [ion binding]; other site
365044012552	nodulation ABC transporter NodI; Provisional; Region: PRK13537
365044012553	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
365044012554	Walker A/P-loop; other site
365044012555	ATP binding site [chemical binding]; other site
365044012556	Q-loop/lid; other site
365044012557	ABC transporter signature motif; other site
365044012558	Walker B; other site
365044012559	D-loop; other site
365044012560	H-loop/switch region; other site
365044012561	ABC-2 type transporter; Region: ABC2_membrane; cl17235
365044012562	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
365044012563	CheB methylesterase; Region: CheB_methylest; pfam01339
365044012564	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012565	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
365044012566	putative ligand binding site [chemical binding]; other site
365044012567	Uncharacterized conserved protein [Function unknown]; Region: COG2353
365044012568	YceI-like domain; Region: YceI; smart00867
365044012569	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
365044012570	Methyltransferase domain; Region: Methyltransf_32; pfam13679
365044012571	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365044012572	serine/threonine protein kinase; Provisional; Region: PRK11768
365044012573	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
365044012574	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
365044012575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
365044012576	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
365044012577	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
365044012578	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044012579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
365044012580	Peptidase M15; Region: Peptidase_M15_3; cl01194
365044012581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
365044012582	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
365044012583	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
365044012584	heat shock protein 90; Provisional; Region: PRK05218
365044012585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012586	ATP binding site [chemical binding]; other site
365044012587	Mg2+ binding site [ion binding]; other site
365044012588	G-X-G motif; other site
365044012589	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
365044012590	PGAP1-like protein; Region: PGAP1; pfam07819
365044012591	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044012592	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044012593	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044012594	active site
365044012595	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
365044012596	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044012597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012598	active site
365044012599	phosphorylation site [posttranslational modification]
365044012600	intermolecular recognition site; other site
365044012601	dimerization interface [polypeptide binding]; other site
365044012602	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012603	DNA binding residues [nucleotide binding]
365044012604	dimerization interface [polypeptide binding]; other site
365044012605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044012606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044012607	Histidine kinase; Region: HisKA_3; pfam07730
365044012608	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
365044012609	Mg2+ binding site [ion binding]; other site
365044012610	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
365044012611	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
365044012612	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
365044012613	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
365044012614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012615	active site
365044012616	phosphorylation site [posttranslational modification]
365044012617	intermolecular recognition site; other site
365044012618	dimerization interface [polypeptide binding]; other site
365044012619	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044012620	DNA binding site [nucleotide binding]
365044012621	sensor protein KdpD; Provisional; Region: PRK10490
365044012622	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
365044012623	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
365044012624	Ligand Binding Site [chemical binding]; other site
365044012625	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
365044012626	GAF domain; Region: GAF_3; pfam13492
365044012627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012628	dimer interface [polypeptide binding]; other site
365044012629	phosphorylation site [posttranslational modification]
365044012630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012631	ATP binding site [chemical binding]; other site
365044012632	Mg2+ binding site [ion binding]; other site
365044012633	G-X-G motif; other site
365044012634	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
365044012635	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
365044012636	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044012637	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
365044012638	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012639	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044012640	ligand binding site [chemical binding]; other site
365044012641	flexible hinge region; other site
365044012642	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044012643	non-specific DNA interactions [nucleotide binding]; other site
365044012644	DNA binding site [nucleotide binding]
365044012645	sequence specific DNA binding site [nucleotide binding]; other site
365044012646	putative cAMP binding site [chemical binding]; other site
365044012647	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012648	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044012649	putative ligand binding site [chemical binding]; other site
365044012650	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044012651	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044012652	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044012653	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
365044012654	acyl-activating enzyme (AAE) consensus motif; other site
365044012655	acyl-activating enzyme (AAE) consensus motif; other site
365044012656	putative AMP binding site [chemical binding]; other site
365044012657	putative active site [active]
365044012658	putative CoA binding site [chemical binding]; other site
365044012659	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044012660	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
365044012661	Walker A/P-loop; other site
365044012662	ATP binding site [chemical binding]; other site
365044012663	Q-loop/lid; other site
365044012664	ABC transporter signature motif; other site
365044012665	Walker B; other site
365044012666	D-loop; other site
365044012667	H-loop/switch region; other site
365044012668	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044012669	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044012670	TM-ABC transporter signature motif; other site
365044012671	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
365044012672	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044012673	TM-ABC transporter signature motif; other site
365044012674	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
365044012675	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012676	putative ligand binding site [chemical binding]; other site
365044012677	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044012678	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
365044012679	Walker A/P-loop; other site
365044012680	ATP binding site [chemical binding]; other site
365044012681	Q-loop/lid; other site
365044012682	ABC transporter signature motif; other site
365044012683	Walker B; other site
365044012684	D-loop; other site
365044012685	H-loop/switch region; other site
365044012686	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
365044012687	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044012688	acyl-activating enzyme (AAE) consensus motif; other site
365044012689	active site
365044012690	AMP binding site [chemical binding]; other site
365044012691	CoA binding site [chemical binding]; other site
365044012692	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044012693	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
365044012694	Biofilm formation and stress response factor; Region: BsmA; pfam10014
365044012695	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
365044012696	hypothetical protein; Provisional; Region: PRK07236
365044012697	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
365044012698	active site
365044012699	FMN binding site [chemical binding]; other site
365044012700	substrate binding site [chemical binding]; other site
365044012701	homotetramer interface [polypeptide binding]; other site
365044012702	catalytic residue [active]
365044012703	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044012704	MarR family; Region: MarR; pfam01047
365044012705	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044012706	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044012707	substrate binding site [chemical binding]; other site
365044012708	oxyanion hole (OAH) forming residues; other site
365044012709	trimer interface [polypeptide binding]; other site
365044012710	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044012711	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044012712	active site
365044012713	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
365044012714	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
365044012715	acyl-activating enzyme (AAE) consensus motif; other site
365044012716	AMP binding site [chemical binding]; other site
365044012717	active site
365044012718	CoA binding site [chemical binding]; other site
365044012719	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044012720	active site
365044012721	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
365044012722	homotrimer interaction site [polypeptide binding]; other site
365044012723	putative active site [active]
365044012724	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012725	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044012726	ligand binding site [chemical binding]; other site
365044012727	flexible hinge region; other site
365044012728	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
365044012729	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012730	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
365044012731	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044012732	non-specific DNA interactions [nucleotide binding]; other site
365044012733	DNA binding site [nucleotide binding]
365044012734	sequence specific DNA binding site [nucleotide binding]; other site
365044012735	putative cAMP binding site [chemical binding]; other site
365044012736	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044012737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012738	active site
365044012739	phosphorylation site [posttranslational modification]
365044012740	intermolecular recognition site; other site
365044012741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012742	DNA binding residues [nucleotide binding]
365044012743	dimerization interface [polypeptide binding]; other site
365044012744	Response regulator receiver domain; Region: Response_reg; pfam00072
365044012745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012746	active site
365044012747	phosphorylation site [posttranslational modification]
365044012748	intermolecular recognition site; other site
365044012749	dimerization interface [polypeptide binding]; other site
365044012750	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
365044012751	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
365044012752	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044012753	dimerization interface [polypeptide binding]; other site
365044012754	PAS domain; Region: PAS; smart00091
365044012755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012756	dimer interface [polypeptide binding]; other site
365044012757	phosphorylation site [posttranslational modification]
365044012758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012759	ATP binding site [chemical binding]; other site
365044012760	Mg2+ binding site [ion binding]; other site
365044012761	G-X-G motif; other site
365044012762	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
365044012763	16S rRNA methyltransferase B; Provisional; Region: PRK10901
365044012764	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
365044012765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012766	S-adenosylmethionine binding site [chemical binding]; other site
365044012767	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
365044012768	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
365044012769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044012770	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044012771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044012772	Peptidase family M48; Region: Peptidase_M48; cl12018
365044012773	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
365044012774	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
365044012775	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
365044012776	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
365044012777	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
365044012778	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
365044012779	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
365044012780	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
365044012781	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
365044012782	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
365044012783	DNA binding site [nucleotide binding]
365044012784	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
365044012785	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
365044012786	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
365044012787	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
365044012788	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
365044012789	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
365044012790	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
365044012791	RPB3 interaction site [polypeptide binding]; other site
365044012792	RPB1 interaction site [polypeptide binding]; other site
365044012793	RPB11 interaction site [polypeptide binding]; other site
365044012794	RPB10 interaction site [polypeptide binding]; other site
365044012795	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
365044012796	peripheral dimer interface [polypeptide binding]; other site
365044012797	core dimer interface [polypeptide binding]; other site
365044012798	L10 interface [polypeptide binding]; other site
365044012799	L11 interface [polypeptide binding]; other site
365044012800	putative EF-Tu interaction site [polypeptide binding]; other site
365044012801	putative EF-G interaction site [polypeptide binding]; other site
365044012802	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
365044012803	23S rRNA interface [nucleotide binding]; other site
365044012804	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
365044012805	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
365044012806	mRNA/rRNA interface [nucleotide binding]; other site
365044012807	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
365044012808	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
365044012809	23S rRNA interface [nucleotide binding]; other site
365044012810	L7/L12 interface [polypeptide binding]; other site
365044012811	putative thiostrepton binding site; other site
365044012812	L25 interface [polypeptide binding]; other site
365044012813	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
365044012814	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
365044012815	putative homodimer interface [polypeptide binding]; other site
365044012816	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
365044012817	heterodimer interface [polypeptide binding]; other site
365044012818	homodimer interface [polypeptide binding]; other site
365044012819	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
365044012820	elongation factor Tu; Reviewed; Region: PRK00049
365044012821	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
365044012822	G1 box; other site
365044012823	GEF interaction site [polypeptide binding]; other site
365044012824	GTP/Mg2+ binding site [chemical binding]; other site
365044012825	Switch I region; other site
365044012826	G2 box; other site
365044012827	G3 box; other site
365044012828	Switch II region; other site
365044012829	G4 box; other site
365044012830	G5 box; other site
365044012831	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
365044012832	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
365044012833	Antibiotic Binding Site [chemical binding]; other site
365044012834	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
365044012835	ligand binding site [chemical binding]; other site
365044012836	active site
365044012837	UGI interface [polypeptide binding]; other site
365044012838	catalytic site [active]
365044012839	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
365044012840	active site
365044012841	ribulose/triose binding site [chemical binding]; other site
365044012842	phosphate binding site [ion binding]; other site
365044012843	substrate (anthranilate) binding pocket [chemical binding]; other site
365044012844	product (indole) binding pocket [chemical binding]; other site
365044012845	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
365044012846	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
365044012847	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
365044012848	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044012849	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
365044012850	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044012851	catalytic residue [active]
365044012852	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
365044012853	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
365044012854	glutamine binding [chemical binding]; other site
365044012855	catalytic triad [active]
365044012856	Chorismate mutase type II; Region: CM_2; smart00830
365044012857	anthranilate synthase component I; Provisional; Region: PRK13565
365044012858	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
365044012859	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
365044012860	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
365044012861	phosphoglycolate phosphatase; Provisional; Region: PRK13222
365044012862	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044012863	motif II; other site
365044012864	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044012865	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044012866	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044012867	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
365044012868	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
365044012869	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
365044012870	substrate binding site [chemical binding]; other site
365044012871	hexamer interface [polypeptide binding]; other site
365044012872	metal binding site [ion binding]; metal-binding site
365044012873	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
365044012874	Site-specific recombinase; Region: SpecificRecomb; pfam10136
365044012875	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
365044012876	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
365044012877	thiamine monophosphate kinase; Provisional; Region: PRK05731
365044012878	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
365044012879	ATP binding site [chemical binding]; other site
365044012880	dimerization interface [polypeptide binding]; other site
365044012881	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
365044012882	tetramer interfaces [polypeptide binding]; other site
365044012883	binuclear metal-binding site [ion binding]; other site
365044012884	Competence-damaged protein; Region: CinA; pfam02464
365044012885	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
365044012886	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012887	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012888	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044012889	putative switch regulator; other site
365044012890	non-specific DNA interactions [nucleotide binding]; other site
365044012891	DNA binding site [nucleotide binding]
365044012892	sequence specific DNA binding site [nucleotide binding]; other site
365044012893	putative cAMP binding site [chemical binding]; other site
365044012894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012895	S-adenosylmethionine binding site [chemical binding]; other site
365044012896	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
365044012897	nucleotide binding site [chemical binding]; other site
365044012898	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365044012899	SBD interface [polypeptide binding]; other site
365044012900	DNA-K related protein; Region: DUF3731; pfam12531
365044012901	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
365044012902	nucleotide binding site [chemical binding]; other site
365044012903	putative NEF/HSP70 interaction site [polypeptide binding]; other site
365044012904	SBD interface [polypeptide binding]; other site
365044012905	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
365044012906	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012907	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
365044012908	ligand binding site [chemical binding]; other site
365044012909	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
365044012910	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
365044012911	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
365044012912	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044012913	oligomeric interface; other site
365044012914	putative active site [active]
365044012915	homodimer interface [polypeptide binding]; other site
365044012916	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
365044012917	active site
365044012918	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
365044012919	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044012920	motif II; other site
365044012921	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044012922	active site
365044012923	catalytic residues [active]
365044012924	metal binding site [ion binding]; metal-binding site
365044012925	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044012926	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044012927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012928	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044012929	active site
365044012930	phosphorylation site [posttranslational modification]
365044012931	intermolecular recognition site; other site
365044012932	dimerization interface [polypeptide binding]; other site
365044012933	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044012934	DNA binding site [nucleotide binding]
365044012935	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
365044012936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012937	dimer interface [polypeptide binding]; other site
365044012938	phosphorylation site [posttranslational modification]
365044012939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012940	ATP binding site [chemical binding]; other site
365044012941	Mg2+ binding site [ion binding]; other site
365044012942	G-X-G motif; other site
365044012943	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365044012944	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
365044012945	active site
365044012946	catalytic tetrad [active]
365044012947	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044012948	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
365044012949	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
365044012950	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
365044012951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012952	dimer interface [polypeptide binding]; other site
365044012953	conserved gate region; other site
365044012954	putative PBP binding loops; other site
365044012955	ABC-ATPase subunit interface; other site
365044012956	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
365044012957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012958	dimer interface [polypeptide binding]; other site
365044012959	conserved gate region; other site
365044012960	putative PBP binding loops; other site
365044012961	ABC-ATPase subunit interface; other site
365044012962	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
365044012963	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
365044012964	Walker A/P-loop; other site
365044012965	ATP binding site [chemical binding]; other site
365044012966	Q-loop/lid; other site
365044012967	ABC transporter signature motif; other site
365044012968	Walker B; other site
365044012969	D-loop; other site
365044012970	H-loop/switch region; other site
365044012971	TOBE domain; Region: TOBE_2; pfam08402
365044012972	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
365044012973	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
365044012974	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
365044012975	glucokinase; Provisional; Region: glk; PRK00292
365044012976	glucokinase, proteobacterial type; Region: glk; TIGR00749
365044012977	Uncharacterized conserved protein [Function unknown]; Region: COG4095
365044012978	LysR family transcriptional regulator; Provisional; Region: PRK14997
365044012979	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044012980	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044012981	putative effector binding pocket; other site
365044012982	dimerization interface [polypeptide binding]; other site
365044012983	LysE type translocator; Region: LysE; cl00565
365044012984	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
365044012985	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044012986	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044012987	dimerization interface [polypeptide binding]; other site
365044012988	psiF repeat; Region: PsiF_repeat; pfam07769
365044012989	psiF repeat; Region: PsiF_repeat; pfam07769
365044012990	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
365044012991	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
365044012992	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
365044012993	active site
365044012994	HIGH motif; other site
365044012995	KMSK motif region; other site
365044012996	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
365044012997	tRNA binding surface [nucleotide binding]; other site
365044012998	anticodon binding site; other site
365044012999	Sporulation related domain; Region: SPOR; pfam05036
365044013000	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
365044013001	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
365044013002	catalytic residues [active]
365044013003	hinge region; other site
365044013004	alpha helical domain; other site
365044013005	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
365044013006	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
365044013007	Surface antigen; Region: Bac_surface_Ag; pfam01103
365044013008	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
365044013009	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
365044013010	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
365044013011	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
365044013012	active site
365044013013	Tetratricopeptide repeat; Region: TPR_12; pfam13424
365044013014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044013015	binding surface
365044013016	TPR motif; other site
365044013017	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
365044013018	OstA-like protein; Region: OstA; pfam03968
365044013019	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
365044013020	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
365044013021	Walker A/P-loop; other site
365044013022	ATP binding site [chemical binding]; other site
365044013023	Q-loop/lid; other site
365044013024	ABC transporter signature motif; other site
365044013025	Walker B; other site
365044013026	D-loop; other site
365044013027	H-loop/switch region; other site
365044013028	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
365044013029	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
365044013030	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
365044013031	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
365044013032	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
365044013033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
365044013034	PIN domain; Region: PIN_3; pfam13470
365044013035	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
365044013036	putative active site [active]
365044013037	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
365044013038	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
365044013039	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044013040	active site
365044013041	nucleotide binding site [chemical binding]; other site
365044013042	HIGH motif; other site
365044013043	KMSKS motif; other site
365044013044	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
365044013045	nudix motif; other site
365044013046	NAD synthetase; Provisional; Region: PRK13981
365044013047	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
365044013048	multimer interface [polypeptide binding]; other site
365044013049	active site
365044013050	catalytic triad [active]
365044013051	protein interface 1 [polypeptide binding]; other site
365044013052	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
365044013053	homodimer interface [polypeptide binding]; other site
365044013054	NAD binding pocket [chemical binding]; other site
365044013055	ATP binding pocket [chemical binding]; other site
365044013056	Mg binding site [ion binding]; other site
365044013057	active-site loop [active]
365044013058	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
365044013059	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
365044013060	active site
365044013061	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
365044013062	catalytic triad [active]
365044013063	conserved cis-peptide bond; other site
365044013064	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
365044013065	nudix motif; other site
365044013066	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
365044013067	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
365044013068	Winged helix-turn helix; Region: HTH_29; pfam13551
365044013069	Winged helix-turn helix; Region: HTH_33; pfam13592
365044013070	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044013071	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
365044013072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044013073	S-adenosylmethionine binding site [chemical binding]; other site
365044013074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013075	dimer interface [polypeptide binding]; other site
365044013076	phosphorylation site [posttranslational modification]
365044013077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013078	ATP binding site [chemical binding]; other site
365044013079	G-X-G motif; other site
365044013080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013081	active site
365044013082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044013083	phosphorylation site [posttranslational modification]
365044013084	intermolecular recognition site; other site
365044013085	dimerization interface [polypeptide binding]; other site
365044013086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013087	dimer interface [polypeptide binding]; other site
365044013088	phosphorylation site [posttranslational modification]
365044013089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013090	ATP binding site [chemical binding]; other site
365044013091	G-X-G motif; other site
365044013092	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044013093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013094	active site
365044013095	phosphorylation site [posttranslational modification]
365044013096	intermolecular recognition site; other site
365044013097	dimerization interface [polypeptide binding]; other site
365044013098	SnoaL-like domain; Region: SnoaL_2; pfam12680
365044013099	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
365044013100	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044013101	DTAP/Switch II; other site
365044013102	Switch I; other site
365044013103	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044013104	P loop; other site
365044013105	Nucleotide binding site [chemical binding]; other site
365044013106	DTAP/Switch II; other site
365044013107	Switch I; other site
365044013108	Restriction endonuclease; Region: Mrr_cat; pfam04471
365044013109	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365044013110	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
365044013111	active site 1 [active]
365044013112	dimer interface [polypeptide binding]; other site
365044013113	hexamer interface [polypeptide binding]; other site
365044013114	active site 2 [active]
365044013115	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
365044013116	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
365044013117	putative active site [active]
365044013118	putative dimer interface [polypeptide binding]; other site
365044013119	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
365044013120	glutathione synthetase; Provisional; Region: PRK05246
365044013121	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
365044013122	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
365044013123	MoxR-like ATPases [General function prediction only]; Region: COG0714
365044013124	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
365044013125	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
365044013126	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
365044013127	metal ion-dependent adhesion site (MIDAS); other site
365044013128	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
365044013129	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
365044013130	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
365044013131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013132	active site
365044013133	phosphorylation site [posttranslational modification]
365044013134	intermolecular recognition site; other site
365044013135	dimerization interface [polypeptide binding]; other site
365044013136	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044013137	DNA binding residues [nucleotide binding]
365044013138	dimerization interface [polypeptide binding]; other site
365044013139	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
365044013140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044013141	putative active site [active]
365044013142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044013143	heme pocket [chemical binding]; other site
365044013144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013145	dimer interface [polypeptide binding]; other site
365044013146	phosphorylation site [posttranslational modification]
365044013147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013148	ATP binding site [chemical binding]; other site
365044013149	G-X-G motif; other site
365044013150	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044013151	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044013152	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
365044013153	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
365044013154	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
365044013155	potassium uptake protein; Region: kup; TIGR00794
365044013156	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
365044013157	Glutamate-cysteine ligase; Region: GshA; pfam08886
365044013158	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
365044013159	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
365044013160	putative catalytic cysteine [active]
365044013161	Hemerythrin-like domain; Region: Hr-like; cd12108
365044013162	Fe binding site [ion binding]; other site
365044013163	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
365044013164	putative FMN binding site [chemical binding]; other site
365044013165	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
365044013166	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
365044013167	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
365044013168	protein-splicing catalytic site; other site
365044013169	thioester formation/cholesterol transfer; other site
365044013170	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
365044013171	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942
365044013172	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
365044013173	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
365044013174	active site clefts [active]
365044013175	zinc binding site [ion binding]; other site
365044013176	dimer interface [polypeptide binding]; other site
365044013177	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
365044013178	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
365044013179	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
365044013180	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
365044013181	4Fe-4S binding domain; Region: Fer4; cl02805
365044013182	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
365044013183	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
365044013184	[4Fe-4S] binding site [ion binding]; other site
365044013185	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044013186	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044013187	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044013188	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
365044013189	molybdopterin cofactor binding site; other site
365044013190	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
365044013191	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
365044013192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044013193	putative substrate translocation pore; other site
365044013194	transcriptional regulator NarL; Provisional; Region: PRK10651
365044013195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013196	active site
365044013197	phosphorylation site [posttranslational modification]
365044013198	intermolecular recognition site; other site
365044013199	dimerization interface [polypeptide binding]; other site
365044013200	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044013201	DNA binding residues [nucleotide binding]
365044013202	dimerization interface [polypeptide binding]; other site
365044013203	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
365044013204	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044013205	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044013206	dimerization interface [polypeptide binding]; other site
365044013207	GAF domain; Region: GAF; pfam01590
365044013208	Histidine kinase; Region: HisKA_3; pfam07730
365044013209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013210	ATP binding site [chemical binding]; other site
365044013211	Mg2+ binding site [ion binding]; other site
365044013212	G-X-G motif; other site
365044013213	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
365044013214	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
365044013215	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
365044013216	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
365044013217	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044013218	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
365044013219	putative DNA binding site [nucleotide binding]; other site
365044013220	putative Zn2+ binding site [ion binding]; other site
365044013221	AsnC family; Region: AsnC_trans_reg; pfam01037
365044013222	ornithine cyclodeaminase; Validated; Region: PRK07589
365044013223	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
365044013224	Arginase family; Region: Arginase; cd09989
365044013225	agmatinase; Region: agmatinase; TIGR01230
365044013226	active site
365044013227	Mn binding site [ion binding]; other site
365044013228	oligomer interface [polypeptide binding]; other site
365044013229	Family description; Region: DsbD_2; pfam13386
365044013230	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
365044013231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044013232	FeS/SAM binding site; other site
365044013233	HemN C-terminal domain; Region: HemN_C; pfam06969
365044013234	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
365044013235	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044013236	ligand binding site [chemical binding]; other site
365044013237	flexible hinge region; other site
365044013238	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044013239	putative switch regulator; other site
365044013240	non-specific DNA interactions [nucleotide binding]; other site
365044013241	DNA binding site [nucleotide binding]
365044013242	sequence specific DNA binding site [nucleotide binding]; other site
365044013243	putative cAMP binding site [chemical binding]; other site
365044013244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
365044013245	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
365044013246	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044013247	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044013248	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
365044013249	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
365044013250	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
365044013251	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
365044013252	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
365044013253	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
365044013254	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
365044013255	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
365044013256	Low-spin heme binding site [chemical binding]; other site
365044013257	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
365044013258	Putative water exit pathway; other site
365044013259	Binuclear center (active site) [active]
365044013260	Putative proton exit pathway; other site
365044013261	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
365044013262	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044013263	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044013264	metal-binding site [ion binding]
365044013265	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044013266	Soluble P-type ATPase [General function prediction only]; Region: COG4087
365044013267	Lipopolysaccharide-assembly; Region: LptE; cl01125
365044013268	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
365044013269	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
365044013270	HIGH motif; other site
365044013271	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
365044013272	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044013273	active site
365044013274	KMSKS motif; other site
365044013275	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
365044013276	tRNA binding surface [nucleotide binding]; other site
365044013277	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
365044013278	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
365044013279	TolR protein; Region: tolR; TIGR02801
365044013280	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
365044013281	dihydrodipicolinate reductase; Provisional; Region: PRK00048
365044013282	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
365044013283	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
365044013284	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
365044013285	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
365044013286	ferric uptake regulator; Provisional; Region: fur; PRK09462
365044013287	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
365044013288	metal binding site 2 [ion binding]; metal-binding site
365044013289	putative DNA binding helix; other site
365044013290	metal binding site 1 [ion binding]; metal-binding site
365044013291	dimer interface [polypeptide binding]; other site
365044013292	structural Zn2+ binding site [ion binding]; other site
365044013293	HPr kinase/phosphorylase; Provisional; Region: PRK05428
365044013294	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
365044013295	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
365044013296	Hpr binding site; other site
365044013297	active site
365044013298	homohexamer subunit interaction site [polypeptide binding]; other site
365044013299	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
365044013300	active site
365044013301	phosphorylation site [posttranslational modification]
365044013302	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
365044013303	30S subunit binding site; other site
365044013304	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
365044013305	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
365044013306	Cl binding site [ion binding]; other site
365044013307	oligomer interface [polypeptide binding]; other site
365044013308	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
365044013309	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
365044013310	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
365044013311	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
365044013312	acyl-activating enzyme (AAE) consensus motif; other site
365044013313	putative AMP binding site [chemical binding]; other site
365044013314	putative active site [active]
365044013315	putative CoA binding site [chemical binding]; other site
365044013316	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
365044013317	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
365044013318	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
365044013319	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
365044013320	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
365044013321	ligand binding site [chemical binding]; other site
365044013322	homodimer interface [polypeptide binding]; other site
365044013323	NAD(P) binding site [chemical binding]; other site
365044013324	trimer interface B [polypeptide binding]; other site
365044013325	trimer interface A [polypeptide binding]; other site
365044013326	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
365044013327	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
365044013328	tetrameric interface [polypeptide binding]; other site
365044013329	NAD binding site [chemical binding]; other site
365044013330	catalytic residues [active]
365044013331	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013333	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044013334	putative effector binding pocket; other site
365044013335	dimerization interface [polypeptide binding]; other site
365044013336	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
365044013337	nudix motif; other site
365044013338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
365044013339	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044013340	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013341	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013342	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
365044013343	putative dimerization interface [polypeptide binding]; other site
365044013344	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044013345	Uncharacterized conserved protein [Function unknown]; Region: COG3777
365044013346	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
365044013347	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
365044013348	active site 2 [active]
365044013349	active site 1 [active]
365044013350	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044013351	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044013352	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
365044013353	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
365044013354	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
365044013355	tetramer interface [polypeptide binding]; other site
365044013356	active site
365044013357	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
365044013358	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044013359	trimer interface [polypeptide binding]; other site
365044013360	eyelet of channel; other site
365044013361	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044013362	tricarballylate utilization protein B; Provisional; Region: PRK15033
365044013363	tricarballylate dehydrogenase; Validated; Region: PRK08274
365044013364	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
365044013365	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
365044013366	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013367	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
365044013368	putative dimerization interface [polypeptide binding]; other site
365044013369	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
365044013370	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
365044013371	Ligand Binding Site [chemical binding]; other site
365044013372	MltA-interacting protein MipA; Region: MipA; cl01504
365044013373	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
365044013374	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044013375	dimer interface [polypeptide binding]; other site
365044013376	ssDNA binding site [nucleotide binding]; other site
365044013377	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044013378	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
365044013379	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
365044013380	putative ion selectivity filter; other site
365044013381	putative pore gating glutamate residue; other site
365044013382	putative H+/Cl- coupling transport residue; other site
365044013383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044013384	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044013385	putative substrate translocation pore; other site
365044013386	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
365044013387	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
365044013388	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
365044013389	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044013390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013391	active site
365044013392	phosphorylation site [posttranslational modification]
365044013393	intermolecular recognition site; other site
365044013394	dimerization interface [polypeptide binding]; other site
365044013395	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044013396	DNA binding site [nucleotide binding]
365044013397	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044013398	HAMP domain; Region: HAMP; pfam00672
365044013399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013400	dimer interface [polypeptide binding]; other site
365044013401	phosphorylation site [posttranslational modification]
365044013402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013403	ATP binding site [chemical binding]; other site
365044013404	Mg2+ binding site [ion binding]; other site
365044013405	G-X-G motif; other site
365044013406	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
365044013407	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365044013408	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
365044013409	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
365044013410	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
365044013411	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
365044013412	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
365044013413	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
365044013414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044013415	dimer interface [polypeptide binding]; other site
365044013416	conserved gate region; other site
365044013417	putative PBP binding loops; other site
365044013418	ABC-ATPase subunit interface; other site
365044013419	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
365044013420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044013421	dimer interface [polypeptide binding]; other site
365044013422	conserved gate region; other site
365044013423	putative PBP binding loops; other site
365044013424	ABC-ATPase subunit interface; other site
365044013425	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044013426	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365044013427	Walker A/P-loop; other site
365044013428	ATP binding site [chemical binding]; other site
365044013429	Q-loop/lid; other site
365044013430	ABC transporter signature motif; other site
365044013431	Walker B; other site
365044013432	D-loop; other site
365044013433	H-loop/switch region; other site
365044013434	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044013435	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
365044013436	Walker A/P-loop; other site
365044013437	ATP binding site [chemical binding]; other site
365044013438	Q-loop/lid; other site
365044013439	ABC transporter signature motif; other site
365044013440	Walker B; other site
365044013441	D-loop; other site
365044013442	H-loop/switch region; other site
365044013443	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
365044013444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044013445	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044013446	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
365044013447	NAD(P) binding site [chemical binding]; other site
365044013448	catalytic residues [active]
365044013449	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044013450	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
365044013451	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
365044013452	FAD binding domain; Region: FAD_binding_4; pfam01565
365044013453	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
365044013454	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
365044013455	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044013456	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
365044013457	active site
365044013458	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
365044013459	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
365044013460	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
365044013461	active site
365044013462	dimer interface [polypeptide binding]; other site
365044013463	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
365044013464	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
365044013465	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
365044013466	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
365044013467	Glycoprotease family; Region: Peptidase_M22; pfam00814
365044013468	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
365044013469	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044013470	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044013471	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
365044013472	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
365044013473	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
365044013474	PhnA protein; Region: PhnA; pfam03831
365044013475	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
365044013476	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
365044013477	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
365044013478	tetramer interface [polypeptide binding]; other site
365044013479	catalytic Zn binding site [ion binding]; other site
365044013480	NADP binding site [chemical binding]; other site
365044013481	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
365044013482	Iron permease FTR1 family; Region: FTR1; cl00475
365044013483	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
365044013484	Sel1-like repeats; Region: SEL1; smart00671
365044013485	Sel1-like repeats; Region: SEL1; smart00671
365044013486	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
365044013487	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
365044013488	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
365044013489	SlyX; Region: SlyX; pfam04102
365044013490	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044013491	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
365044013492	dimerization interface [polypeptide binding]; other site
365044013493	ligand binding site [chemical binding]; other site
365044013494	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
365044013495	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
365044013496	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
365044013497	ATP-grasp domain; Region: ATP-grasp; pfam02222
365044013498	AIR carboxylase; Region: AIRC; pfam00731
365044013499	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
365044013500	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044013501	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
365044013502	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
365044013503	conserved cys residue [active]
365044013504	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
365044013505	ATP binding site [chemical binding]; other site
365044013506	active site
365044013507	substrate binding site [chemical binding]; other site
365044013508	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
365044013509	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
365044013510	intersubunit interface [polypeptide binding]; other site
365044013511	active site
365044013512	zinc binding site [ion binding]; other site
365044013513	Na+ binding site [ion binding]; other site
365044013514	sensor protein QseC; Provisional; Region: PRK10337
365044013515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013516	dimer interface [polypeptide binding]; other site
365044013517	phosphorylation site [posttranslational modification]
365044013518	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
365044013519	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
365044013520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013521	active site
365044013522	phosphorylation site [posttranslational modification]
365044013523	intermolecular recognition site; other site
365044013524	dimerization interface [polypeptide binding]; other site
365044013525	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044013526	DNA binding site [nucleotide binding]
365044013527	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
365044013528	active site
365044013529	pyruvate kinase; Provisional; Region: PRK05826
365044013530	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
365044013531	domain interfaces; other site
365044013532	active site
365044013533	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
365044013534	Phosphoglycerate kinase; Region: PGK; pfam00162
365044013535	substrate binding site [chemical binding]; other site
365044013536	hinge regions; other site
365044013537	ADP binding site [chemical binding]; other site
365044013538	catalytic site [active]
365044013539	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
365044013540	AzlC protein; Region: AzlC; pfam03591
365044013541	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
365044013542	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
365044013543	putative active site [active]
365044013544	substrate binding site [chemical binding]; other site
365044013545	putative cosubstrate binding site; other site
365044013546	catalytic site [active]
365044013547	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
365044013548	substrate binding site [chemical binding]; other site
365044013549	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
365044013550	active site
365044013551	catalytic residues [active]
365044013552	metal binding site [ion binding]; metal-binding site
365044013553	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044013554	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044013555	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044013556	Probable transposase; Region: OrfB_IS605; pfam01385
365044013557	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044013558	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
365044013559	DNA protecting protein DprA; Region: dprA; TIGR00732
365044013560	Protein of unknown function (DUF494); Region: DUF494; pfam04361
365044013561	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
365044013562	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
365044013563	Protein export membrane protein; Region: SecD_SecF; pfam02355
365044013564	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
365044013565	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
365044013566	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
365044013567	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
365044013568	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
365044013569	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
365044013570	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
365044013571	dimer interface [polypeptide binding]; other site
365044013572	PYR/PP interface [polypeptide binding]; other site
365044013573	TPP binding site [chemical binding]; other site
365044013574	substrate binding site [chemical binding]; other site
365044013575	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
365044013576	TPP-binding site [chemical binding]; other site
365044013577	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
365044013578	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044013579	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044013580	putative DNA binding site [nucleotide binding]; other site
365044013581	putative Zn2+ binding site [ion binding]; other site
365044013582	AsnC family; Region: AsnC_trans_reg; pfam01037
365044013583	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
365044013584	MltA specific insert domain; Region: MltA; smart00925
365044013585	3D domain; Region: 3D; pfam06725
365044013586	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
365044013587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013588	active site
365044013589	phosphorylation site [posttranslational modification]
365044013590	intermolecular recognition site; other site
365044013591	dimerization interface [polypeptide binding]; other site
365044013592	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044013593	DNA binding residues [nucleotide binding]
365044013594	dimerization interface [polypeptide binding]; other site
365044013595	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
365044013596	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044013597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044013598	putative active site [active]
365044013599	heme pocket [chemical binding]; other site
365044013600	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013601	dimer interface [polypeptide binding]; other site
365044013602	phosphorylation site [posttranslational modification]
365044013603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013604	ATP binding site [chemical binding]; other site
365044013605	Mg2+ binding site [ion binding]; other site
365044013606	G-X-G motif; other site
365044013607	nitrilase; Region: PLN02798
365044013608	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
365044013609	putative active site [active]
365044013610	catalytic triad [active]
365044013611	dimer interface [polypeptide binding]; other site
365044013612	TIGR02099 family protein; Region: TIGR02099
365044013613	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
365044013614	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044013615	metal binding triad; other site
365044013616	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
365044013617	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044013618	metal binding triad; other site
365044013619	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
365044013620	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044013621	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
365044013622	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044013623	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044013624	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
365044013625	HlyD family secretion protein; Region: HlyD_3; pfam13437
365044013626	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044013627	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
365044013628	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
365044013629	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013630	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013631	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044013632	putative effector binding pocket; other site
365044013633	dimerization interface [polypeptide binding]; other site
365044013634	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044013635	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
365044013636	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
365044013637	active site
365044013638	dimer interface [polypeptide binding]; other site
365044013639	metal binding site [ion binding]; metal-binding site
365044013640	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
365044013641	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
365044013642	NAD(P) binding site [chemical binding]; other site
365044013643	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
365044013644	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
365044013645	active site
365044013646	nucleotide binding site [chemical binding]; other site
365044013647	HIGH motif; other site
365044013648	KMSKS motif; other site
365044013649	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
365044013650	dinuclear metal binding motif [ion binding]; other site
365044013651	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
365044013652	catalytic residues [active]
365044013653	dimer interface [polypeptide binding]; other site
365044013654	putative glutathione S-transferase; Provisional; Region: PRK10357
365044013655	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
365044013656	putative C-terminal domain interface [polypeptide binding]; other site
365044013657	putative GSH binding site (G-site) [chemical binding]; other site
365044013658	putative dimer interface [polypeptide binding]; other site
365044013659	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
365044013660	dimer interface [polypeptide binding]; other site
365044013661	N-terminal domain interface [polypeptide binding]; other site
365044013662	putative substrate binding pocket (H-site) [chemical binding]; other site
365044013663	adenylosuccinate lyase; Provisional; Region: PRK09285
365044013664	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
365044013665	tetramer interface [polypeptide binding]; other site
365044013666	active site
365044013667	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
365044013668	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
365044013669	yybP-ykoY element as predicted by Rfam (RF00080), score 45.62
365044013670	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
365044013671	Membrane protein of unknown function; Region: DUF360; pfam04020
365044013672	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
365044013673	Peptidase family M48; Region: Peptidase_M48; pfam01435
365044013674	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
365044013675	trimer interface [polypeptide binding]; other site
365044013676	dimer interface [polypeptide binding]; other site
365044013677	putative active site [active]
365044013678	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044013679	active site
365044013680	DNA binding site [nucleotide binding]
365044013681	Int/Topo IB signature motif; other site
365044013682	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044013683	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044013684	active site
365044013685	substrate binding site [chemical binding]; other site
365044013686	Mg2+ binding site [ion binding]; other site
365044013687	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365044013688	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044013689	putative active site [active]
365044013690	putative NTP binding site [chemical binding]; other site
365044013691	putative nucleic acid binding site [nucleotide binding]; other site
365044013692	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
365044013693	active site
365044013694	DNA binding site [nucleotide binding]
365044013695	catalytic site [active]
365044013696	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044013697	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365044013698	catalytic residues [active]
365044013699	catalytic nucleophile [active]
365044013700	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044013701	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044013702	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044013703	Synaptic Site I dimer interface [polypeptide binding]; other site
365044013704	DNA binding site [nucleotide binding]
365044013705	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365044013706	DNA-binding interface [nucleotide binding]; DNA binding site
365044013707	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
365044013708	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
365044013709	H-NS histone family; Region: Histone_HNS; pfam00816
365044013710	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
365044013711	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
365044013712	O-Antigen ligase; Region: Wzy_C; pfam04932
365044013713	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
365044013714	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
365044013715	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
365044013716	Pilin (bacterial filament); Region: Pilin; pfam00114
365044013717	Pilin (bacterial filament); Region: Pilin; pfam00114
365044013718	Pilin (bacterial filament); Region: Pilin; pfam00114
365044013719	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365044013720	active site
365044013721	NTP binding site [chemical binding]; other site
365044013722	metal binding triad [ion binding]; metal-binding site
365044013723	antibiotic binding site [chemical binding]; other site
365044013724	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
365044013725	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
365044013726	phosphopeptide binding site; other site
365044013727	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044013728	Protein phosphatase 2C; Region: PP2C; pfam00481
365044013729	active site
365044013730	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
365044013731	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
365044013732	CoA binding domain; Region: CoA_binding; smart00881
365044013733	CoA-ligase; Region: Ligase_CoA; pfam00549
365044013734	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
365044013735	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
365044013736	CoA-ligase; Region: Ligase_CoA; pfam00549
365044013737	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
365044013738	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
365044013739	recombination regulator RecX; Reviewed; Region: recX; PRK00117
365044013740	recombinase A; Provisional; Region: recA; PRK09354
365044013741	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
365044013742	hexamer interface [polypeptide binding]; other site
365044013743	Walker A motif; other site
365044013744	ATP binding site [chemical binding]; other site
365044013745	Walker B motif; other site
365044013746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044013747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013748	active site
365044013749	phosphorylation site [posttranslational modification]
365044013750	intermolecular recognition site; other site
365044013751	dimerization interface [polypeptide binding]; other site
365044013752	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044013753	DNA binding site [nucleotide binding]
365044013754	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
365044013755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013756	dimer interface [polypeptide binding]; other site
365044013757	phosphorylation site [posttranslational modification]
365044013758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013759	ATP binding site [chemical binding]; other site
365044013760	Mg2+ binding site [ion binding]; other site
365044013761	G-X-G motif; other site
365044013762	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
365044013763	Peptidase C26; Region: Peptidase_C26; pfam07722
365044013764	catalytic triad [active]
365044013765	FMN-binding domain; Region: FMN_bind; cl01081
365044013766	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
365044013767	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044013768	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044013769	ApbE family; Region: ApbE; pfam02424
365044013770	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
365044013771	DNA topoisomerase III; Provisional; Region: PRK14724
365044013772	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
365044013773	active site
365044013774	putative interdomain interaction site [polypeptide binding]; other site
365044013775	putative metal-binding site [ion binding]; other site
365044013776	putative nucleotide binding site [chemical binding]; other site
365044013777	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
365044013778	domain I; other site
365044013779	DNA binding groove [nucleotide binding]
365044013780	phosphate binding site [ion binding]; other site
365044013781	domain II; other site
365044013782	domain III; other site
365044013783	nucleotide binding site [chemical binding]; other site
365044013784	catalytic site [active]
365044013785	domain IV; other site
365044013786	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
365044013787	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
365044013788	SWI complex, BAF60b domains; Region: SWIB; smart00151
365044013789	Proteins containing SET domain [General function prediction only]; Region: COG2940
365044013790	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
365044013791	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
365044013792	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
365044013793	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
365044013794	putative hydrolase; Provisional; Region: PRK11460
365044013795	Predicted esterase [General function prediction only]; Region: COG0400
365044013796	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
365044013797	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
365044013798	NnrS protein; Region: NnrS; pfam05940
365044013799	Nuclease-related domain; Region: NERD; pfam08378
365044013800	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044013801	Family description; Region: UvrD_C_2; pfam13538
365044013802	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365044013803	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
365044013804	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044013805	putative active site [active]
365044013806	putative NTP binding site [chemical binding]; other site
365044013807	putative nucleic acid binding site [nucleotide binding]; other site
365044013808	PIN domain; Region: PIN_3; pfam13470
365044013809	Helix-turn-helix domain; Region: HTH_17; cl17695
365044013810	Fic family protein [Function unknown]; Region: COG3177
365044013811	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
365044013812	Fic/DOC family; Region: Fic; pfam02661
365044013813	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
365044013814	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044013815	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044013816	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
365044013817	C-terminal domain interface [polypeptide binding]; other site
365044013818	GSH binding site (G-site) [chemical binding]; other site
365044013819	dimer interface [polypeptide binding]; other site
365044013820	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044013821	N-terminal domain interface [polypeptide binding]; other site
365044013822	dimer interface [polypeptide binding]; other site
365044013823	substrate binding pocket (H-site) [chemical binding]; other site
365044013824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044013825	S-adenosylmethionine binding site [chemical binding]; other site
365044013826	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044013827	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044013828	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
365044013829	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
365044013830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013831	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
365044013832	NAD(P) binding site [chemical binding]; other site
365044013833	active site
365044013834	short chain dehydrogenase; Provisional; Region: PRK12937
365044013835	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
365044013836	NADP binding site [chemical binding]; other site
365044013837	homodimer interface [polypeptide binding]; other site
365044013838	active site
365044013839	substrate binding site [chemical binding]; other site
365044013840	transcriptional regulator; Provisional; Region: PRK10632
365044013841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013842	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
365044013843	putative effector binding pocket; other site
365044013844	putative dimerization interface [polypeptide binding]; other site
365044013845	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
365044013846	dimer interface [polypeptide binding]; other site
365044013847	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044013848	Pirin; Region: Pirin; pfam02678
365044013849	Pirin-related protein [General function prediction only]; Region: COG1741
365044013850	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
365044013851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013852	Response regulator receiver domain; Region: Response_reg; pfam00072
365044013853	active site
365044013854	phosphorylation site [posttranslational modification]
365044013855	intermolecular recognition site; other site
365044013856	dimerization interface [polypeptide binding]; other site
365044013857	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044013858	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
365044013859	Dehydroquinase class II; Region: DHquinase_II; pfam01220
365044013860	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
365044013861	trimer interface [polypeptide binding]; other site
365044013862	active site
365044013863	dimer interface [polypeptide binding]; other site
365044013864	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
365044013865	Heavy-metal-associated domain; Region: HMA; pfam00403
365044013866	metal-binding site [ion binding]
365044013867	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
365044013868	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044013869	Soluble P-type ATPase [General function prediction only]; Region: COG4087
365044013870	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
365044013871	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
365044013872	DNA binding residues [nucleotide binding]
365044013873	dimer interface [polypeptide binding]; other site
365044013874	putative metal binding site [ion binding]; other site
365044013875	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
365044013876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044013877	putative substrate translocation pore; other site
365044013878	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013879	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013880	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044013881	dimerization interface [polypeptide binding]; other site
365044013882	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
365044013883	cytosine deaminase; Validated; Region: PRK07572
365044013884	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
365044013885	active site
365044013886	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044013887	Winged helix-turn helix; Region: HTH_29; pfam13551
365044013888	Homeodomain-like domain; Region: HTH_32; pfam13565
365044013889	Abortive infection C-terminus; Region: Abi_C; pfam14355
365044013890	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
365044013891	RNB domain; Region: RNB; pfam00773
365044013892	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
365044013893	RNA binding site [nucleotide binding]; other site
365044013894	Uncharacterized conserved protein [Function unknown]; Region: COG3339
365044013895	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
365044013896	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
365044013897	Surface antigen; Region: Bac_surface_Ag; pfam01103
365044013898	haemagglutination activity domain; Region: Haemagg_act; smart00912
365044013899	FecR protein; Region: FecR; pfam04773
365044013900	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044013901	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
365044013902	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044013903	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
365044013904	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
365044013905	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
365044013906	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
365044013907	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
365044013908	homodimer interface [polypeptide binding]; other site
365044013909	active site
365044013910	FMN binding site [chemical binding]; other site
365044013911	substrate binding site [chemical binding]; other site
365044013912	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044013913	phenylhydantoinase; Validated; Region: PRK08323
365044013914	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
365044013915	tetramer interface [polypeptide binding]; other site
365044013916	active site
365044013917	allantoate amidohydrolase; Reviewed; Region: PRK12893
365044013918	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
365044013919	active site
365044013920	metal binding site [ion binding]; metal-binding site
365044013921	dimer interface [polypeptide binding]; other site
365044013922	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
365044013923	heme-binding site [chemical binding]; other site
365044013924	Protein of unknown function DUF86; Region: DUF86; cl01031
365044013925	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
365044013926	SnoaL-like domain; Region: SnoaL_3; pfam13474
365044013927	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
365044013928	dimer interface [polypeptide binding]; other site
365044013929	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
365044013930	Cytochrome P450; Region: p450; cl12078
365044013931	biotin synthase; Region: bioB; TIGR00433
365044013932	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044013933	FeS/SAM binding site; other site
365044013934	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
365044013935	AAA domain; Region: AAA_26; pfam13500
365044013936	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
365044013937	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
365044013938	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
365044013939	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044013940	catalytic residue [active]
365044013941	DDE superfamily endonuclease; Region: DDE_3; pfam13358
365044013942	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044013943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044013944	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
365044013945	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013946	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
365044013947	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044013948	dimerization interface [polypeptide binding]; other site
365044013949	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
365044013950	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044013951	inhibitor-cofactor binding pocket; inhibition site
365044013952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044013953	catalytic residue [active]
365044013954	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
365044013955	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044013956	ligand binding site [chemical binding]; other site
365044013957	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044013958	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044013959	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044013960	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044013961	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044013962	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
365044013963	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044013964	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044013965	dimerization interface [polypeptide binding]; other site
365044013966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013967	ATP binding site [chemical binding]; other site
365044013968	Mg2+ binding site [ion binding]; other site
365044013969	G-X-G motif; other site
365044013970	Uncharacterized conserved protein [Function unknown]; Region: COG3287
365044013971	FIST N domain; Region: FIST; pfam08495
365044013972	FIST C domain; Region: FIST_C; pfam10442
365044013973	PAS fold; Region: PAS_4; pfam08448
365044013974	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
365044013975	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044013976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013977	ATP binding site [chemical binding]; other site
365044013978	Mg2+ binding site [ion binding]; other site
365044013979	G-X-G motif; other site
365044013980	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044013981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013982	active site
365044013983	phosphorylation site [posttranslational modification]
365044013984	intermolecular recognition site; other site
365044013985	dimerization interface [polypeptide binding]; other site
365044013986	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013987	dimer interface [polypeptide binding]; other site
365044013988	phosphorylation site [posttranslational modification]
365044013989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013990	ATP binding site [chemical binding]; other site
365044013991	Mg2+ binding site [ion binding]; other site
365044013992	G-X-G motif; other site
365044013993	Response regulator receiver domain; Region: Response_reg; pfam00072
365044013994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013995	active site
365044013996	phosphorylation site [posttranslational modification]
365044013997	intermolecular recognition site; other site
365044013998	dimerization interface [polypeptide binding]; other site
365044013999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044014000	dimer interface [polypeptide binding]; other site
365044014001	phosphorylation site [posttranslational modification]
365044014002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044014003	ATP binding site [chemical binding]; other site
365044014004	Mg2+ binding site [ion binding]; other site
365044014005	G-X-G motif; other site
365044014006	Response regulator receiver domain; Region: Response_reg; pfam00072
365044014007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044014008	active site
365044014009	phosphorylation site [posttranslational modification]
365044014010	intermolecular recognition site; other site
365044014011	dimerization interface [polypeptide binding]; other site
365044014012	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044014013	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044014014	putative active site [active]
365044014015	heme pocket [chemical binding]; other site
365044014016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044014017	dimer interface [polypeptide binding]; other site
365044014018	phosphorylation site [posttranslational modification]
365044014019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044014020	ATP binding site [chemical binding]; other site
365044014021	Mg2+ binding site [ion binding]; other site
365044014022	G-X-G motif; other site
365044014023	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
365044014024	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044014025	putative ligand binding site [chemical binding]; other site
365044014026	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
365044014027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
365044014028	Walker A/P-loop; other site
365044014029	ATP binding site [chemical binding]; other site
365044014030	Q-loop/lid; other site
365044014031	ABC transporter signature motif; other site
365044014032	Walker B; other site
365044014033	D-loop; other site
365044014034	H-loop/switch region; other site
365044014035	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
365044014036	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044014037	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
365044014038	TM-ABC transporter signature motif; other site
365044014039	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
365044014040	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
365044014041	TM-ABC transporter signature motif; other site
365044014042	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
365044014043	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044014044	substrate binding site [chemical binding]; other site
365044014045	activation loop (A-loop); other site
365044014046	AAA ATPase domain; Region: AAA_16; pfam13191
365044014047	Predicted ATPase [General function prediction only]; Region: COG3899
365044014048	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044014049	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
365044014050	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044014051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044014052	ATP binding site [chemical binding]; other site
365044014053	Mg2+ binding site [ion binding]; other site
365044014054	G-X-G motif; other site
365044014055	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
365044014056	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
365044014057	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
365044014058	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
365044014059	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365044014060	TPP-binding site [chemical binding]; other site
365044014061	dimer interface [polypeptide binding]; other site
365044014062	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044014063	PYR/PP interface [polypeptide binding]; other site
365044014064	dimer interface [polypeptide binding]; other site
365044014065	TPP binding site [chemical binding]; other site
365044014066	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044014067	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
365044014068	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
365044014069	Substrate binding site; other site
365044014070	metal-binding site
365044014071	proline aminopeptidase P II; Provisional; Region: PRK10879
365044014072	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
365044014073	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
365044014074	active site
365044014075	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
365044014076	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044014077	FOG: CBS domain [General function prediction only]; Region: COG0517
365044014078	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
365044014079	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044014080	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
365044014081	Walker A/P-loop; other site
365044014082	ATP binding site [chemical binding]; other site
365044014083	Q-loop/lid; other site
365044014084	ABC transporter signature motif; other site
365044014085	Walker B; other site
365044014086	D-loop; other site
365044014087	H-loop/switch region; other site
365044014088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044014089	dimer interface [polypeptide binding]; other site
365044014090	conserved gate region; other site
365044014091	putative PBP binding loops; other site
365044014092	ABC-ATPase subunit interface; other site
365044014093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044014094	dimer interface [polypeptide binding]; other site
365044014095	conserved gate region; other site
365044014096	putative PBP binding loops; other site
365044014097	ABC-ATPase subunit interface; other site
365044014098	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044014099	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044014100	substrate binding pocket [chemical binding]; other site
365044014101	membrane-bound complex binding site; other site
365044014102	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
365044014103	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
365044014104	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
365044014105	putative active site [active]
365044014106	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
365044014107	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044014108	allantoate amidohydrolase; Reviewed; Region: PRK12893
365044014109	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
365044014110	active site
365044014111	metal binding site [ion binding]; metal-binding site
365044014112	dimer interface [polypeptide binding]; other site
365044014113	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
365044014114	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044014115	tetramer interface [polypeptide binding]; other site
365044014116	active site
365044014117	catalytic triad [active]
365044014118	dimer interface [polypeptide binding]; other site
365044014119	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
365044014120	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
365044014121	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
365044014122	Glutamate binding site [chemical binding]; other site
365044014123	NAD binding site [chemical binding]; other site
365044014124	catalytic residues [active]
365044014125	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044014126	Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434
365044014127	malic enzyme; Reviewed; Region: PRK12862
365044014128	Malic enzyme, N-terminal domain; Region: malic; pfam00390
365044014129	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
365044014130	putative NAD(P) binding site [chemical binding]; other site
365044014131	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
365044014132	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
365044014133	putative RNAase interaction site [polypeptide binding]; other site
365044014134	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
365044014135	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
365044014136	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
365044014137	SurA N-terminal domain; Region: SurA_N; pfam09312
365044014138	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
365044014139	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
365044014140	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
365044014141	Organic solvent tolerance protein; Region: OstA_C; pfam04453
365044014142	Phosphotransferase enzyme family; Region: APH; pfam01636
365044014143	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
365044014144	substrate binding site [chemical binding]; other site
365044014145	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
365044014146	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
365044014147	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044014148	active site
365044014149	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
365044014150	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044014151	DNA-binding site [nucleotide binding]; DNA binding site
365044014152	UTRA domain; Region: UTRA; pfam07702
365044014153	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044014154	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
365044014155	hypothetical protein; Provisional; Region: PRK07907
365044014156	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
365044014157	metal binding site [ion binding]; metal-binding site
365044014158	putative dimer interface [polypeptide binding]; other site
365044014159	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044014160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044014161	active site
365044014162	phosphorylation site [posttranslational modification]
365044014163	intermolecular recognition site; other site
365044014164	dimerization interface [polypeptide binding]; other site
365044014165	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044014166	DNA binding residues [nucleotide binding]
365044014167	dimerization interface [polypeptide binding]; other site
365044014168	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
365044014169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365044014170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044014171	ATP binding site [chemical binding]; other site
365044014172	Mg2+ binding site [ion binding]; other site
365044014173	G-X-G motif; other site
365044014174	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044014175	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
365044014176	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044014177	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044014178	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044014179	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
365044014180	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044014181	metal-binding site [ion binding]
365044014182	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044014183	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044014184	metal-binding site [ion binding]
365044014185	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044014186	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044014187	metal-binding site [ion binding]
365044014188	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044014189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044014190	motif II; other site
365044014191	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
365044014192	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
365044014193	DNA binding residues [nucleotide binding]
365044014194	dimer interface [polypeptide binding]; other site
365044014195	copper binding site [ion binding]; other site
365044014196	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
365044014197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044014198	Probable transposase; Region: OrfB_IS605; pfam01385
365044014199	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044014200	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
365044014201	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044014202	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
365044014203	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
365044014204	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
365044014205	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
365044014206	Sulfate transporter family; Region: Sulfate_transp; pfam00916
365044014207	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
365044014208	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
365044014209	Chromate transporter; Region: Chromate_transp; pfam02417
365044014210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044014211	S-adenosylmethionine binding site [chemical binding]; other site
365044014212	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
365044014213	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
365044014214	Predicted membrane protein [Function unknown]; Region: COG2119
365044014215	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
365044014216	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
365044014217	yybP-ykoY element as predicted by Rfam (RF00080), score 54.16
365044014218	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
365044014219	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
365044014220	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
365044014221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
365044014222	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
365044014223	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044014224	active site
365044014225	motif I; other site
365044014226	motif II; other site
365044014227	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
365044014228	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
365044014229	putative active site [active]
365044014230	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
365044014231	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
365044014232	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
365044014233	TrkA-N domain; Region: TrkA_N; pfam02254
365044014234	TrkA-C domain; Region: TrkA_C; pfam02080
365044014235	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044014236	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044014237	ligand binding site [chemical binding]; other site
365044014238	flexible hinge region; other site
365044014239	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
365044014240	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
365044014241	trmE is a tRNA modification GTPase; Region: trmE; cd04164
365044014242	G1 box; other site
365044014243	GTP/Mg2+ binding site [chemical binding]; other site
365044014244	Switch I region; other site
365044014245	G2 box; other site
365044014246	Switch II region; other site
365044014247	G3 box; other site
365044014248	G4 box; other site
365044014249	G5 box; other site
365044014250	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
365044014251	membrane protein insertase; Provisional; Region: PRK01318
365044014252	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
365044014253	Haemolytic domain; Region: Haemolytic; cl00506
365044014254	Ribonuclease P; Region: Ribonuclease_P; cl00457
365044014255	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
365044014256	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
365044014257	DnaA N-terminal domain; Region: DnaA_N; pfam11638
365044014258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044014259	Walker A motif; other site
365044014260	ATP binding site [chemical binding]; other site
365044014261	Walker B motif; other site
365044014262	arginine finger; other site
365044014263	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
365044014264	DnaA box-binding interface [nucleotide binding]; other site
365044014265	DNA polymerase III subunit beta; Validated; Region: PRK05643
365044014266	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
365044014267	putative DNA binding surface [nucleotide binding]; other site
365044014268	dimer interface [polypeptide binding]; other site
365044014269	beta-clamp/clamp loader binding surface; other site
365044014270	beta-clamp/translesion DNA polymerase binding surface; other site
365044014271	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
365044014272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044014273	ATP binding site [chemical binding]; other site
365044014274	Mg2+ binding site [ion binding]; other site
365044014275	G-X-G motif; other site
365044014276	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
365044014277	anchoring element; other site
365044014278	dimer interface [polypeptide binding]; other site
365044014279	ATP binding site [chemical binding]; other site
365044014280	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
365044014281	active site
365044014282	putative metal-binding site [ion binding]; other site
365044014283	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
365044014284	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365044014285	active site
365044014286	catalytic site [active]
365044014287	substrate binding site [chemical binding]; other site
365044014288	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
365044014289	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793