-- dump date 20140619_233308 -- class Genbank::misc_feature -- table misc_feature_note -- id note 592029000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 592029000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 592029000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029000004 Walker A motif; other site 592029000005 ATP binding site [chemical binding]; other site 592029000006 Walker B motif; other site 592029000007 arginine finger; other site 592029000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 592029000009 DnaA box-binding interface [nucleotide binding]; other site 592029000010 Low molecular weight phosphatase family; Region: LMWPc; cd00115 592029000011 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 592029000012 active site 592029000013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592029000014 active site 592029000015 CoA binding site [chemical binding]; other site 592029000016 AMP binding site [chemical binding]; other site 592029000017 CAAX protease self-immunity; Region: Abi; pfam02517 592029000018 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 592029000019 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 592029000020 active site 592029000021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 592029000022 Predicted transcriptional regulators [Transcription]; Region: COG1695 592029000023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592029000024 putative Zn2+ binding site [ion binding]; other site 592029000025 putative DNA binding site [nucleotide binding]; other site 592029000026 PspC domain; Region: PspC; pfam04024 592029000027 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 592029000028 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 592029000029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029000030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029000031 Cupin domain; Region: Cupin_2; cl17218 592029000032 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 592029000033 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592029000034 Patatin-like phospholipase; Region: Patatin; pfam01734 592029000035 active site 592029000036 nucleophile elbow; other site 592029000037 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 592029000038 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000039 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029000040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029000041 active site 592029000042 phosphorylation site [posttranslational modification] 592029000043 intermolecular recognition site; other site 592029000044 dimerization interface [polypeptide binding]; other site 592029000045 LytTr DNA-binding domain; Region: LytTR; smart00850 592029000046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029000047 dimer interface [polypeptide binding]; other site 592029000048 phosphorylation site [posttranslational modification] 592029000049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029000050 ATP binding site [chemical binding]; other site 592029000051 Mg2+ binding site [ion binding]; other site 592029000052 G-X-G motif; other site 592029000053 Uncharacterized conserved protein [Function unknown]; Region: COG3287 592029000054 FIST N domain; Region: FIST; pfam08495 592029000055 FIST C domain; Region: FIST_C; pfam10442 592029000056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592029000057 PAS domain; Region: PAS_9; pfam13426 592029000058 putative active site [active] 592029000059 heme pocket [chemical binding]; other site 592029000060 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 592029000061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592029000062 putative active site [active] 592029000063 heme pocket [chemical binding]; other site 592029000064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029000065 dimer interface [polypeptide binding]; other site 592029000066 phosphorylation site [posttranslational modification] 592029000067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029000068 ATP binding site [chemical binding]; other site 592029000069 Mg2+ binding site [ion binding]; other site 592029000070 G-X-G motif; other site 592029000071 Heme NO binding; Region: HNOB; pfam07700 592029000072 Response regulator receiver domain; Region: Response_reg; pfam00072 592029000073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029000074 active site 592029000075 phosphorylation site [posttranslational modification] 592029000076 intermolecular recognition site; other site 592029000077 dimerization interface [polypeptide binding]; other site 592029000078 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 592029000079 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 592029000080 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 592029000081 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 592029000082 FMN binding site [chemical binding]; other site 592029000083 substrate binding site [chemical binding]; other site 592029000084 putative catalytic residue [active] 592029000085 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 592029000086 active site 592029000087 catalytic triad [active] 592029000088 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000089 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 592029000090 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 592029000091 Fasciclin domain; Region: Fasciclin; pfam02469 592029000092 Fasciclin domain; Region: Fasciclin; pfam02469 592029000093 Fasciclin domain; Region: Fasciclin; pfam02469 592029000094 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 592029000095 Fasciclin domain; Region: Fasciclin; cl02663 592029000096 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592029000097 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 592029000098 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 592029000099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592029000100 RNA binding surface [nucleotide binding]; other site 592029000101 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 592029000102 probable active site [active] 592029000103 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029000104 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029000105 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 592029000106 DinB superfamily; Region: DinB_2; pfam12867 592029000107 Outer membrane efflux protein; Region: OEP; pfam02321 592029000108 Outer membrane efflux protein; Region: OEP; pfam02321 592029000109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592029000110 HlyD family secretion protein; Region: HlyD; pfam00529 592029000111 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029000112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592029000113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029000114 Walker A/P-loop; other site 592029000115 ATP binding site [chemical binding]; other site 592029000116 Q-loop/lid; other site 592029000117 ABC transporter signature motif; other site 592029000118 Walker B; other site 592029000119 D-loop; other site 592029000120 H-loop/switch region; other site 592029000121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592029000122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592029000123 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000124 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 592029000125 active site 592029000126 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 592029000127 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 592029000128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029000129 S-adenosylmethionine binding site [chemical binding]; other site 592029000130 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 592029000131 triosephosphate isomerase; Provisional; Region: PRK14567 592029000132 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 592029000133 substrate binding site [chemical binding]; other site 592029000134 dimer interface [polypeptide binding]; other site 592029000135 catalytic triad [active] 592029000136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592029000137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592029000138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592029000139 putative PBP binding loops; other site 592029000140 dimer interface [polypeptide binding]; other site 592029000141 ABC-ATPase subunit interface; other site 592029000142 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 592029000143 active site 592029000144 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 592029000145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592029000146 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 592029000147 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 592029000148 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 592029000149 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 592029000150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029000151 nucleotide binding region [chemical binding]; other site 592029000152 ATP-binding site [chemical binding]; other site 592029000153 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 592029000154 membrane ATPase/protein kinase; Provisional; Region: PRK09435 592029000155 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 592029000156 Walker A; other site 592029000157 Helix-turn-helix domain; Region: HTH_18; pfam12833 592029000158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029000159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029000160 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029000161 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 592029000162 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 592029000163 active site 592029000164 Zn binding site [ion binding]; other site 592029000165 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 592029000166 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 592029000167 putative active site [active] 592029000168 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 592029000169 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 592029000170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592029000171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592029000172 active site 592029000173 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 592029000174 OsmC-like protein; Region: OsmC; cl00767 592029000175 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592029000176 active site 592029000177 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592029000178 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 592029000179 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 592029000180 Walker A/P-loop; other site 592029000181 ATP binding site [chemical binding]; other site 592029000182 Q-loop/lid; other site 592029000183 ABC transporter signature motif; other site 592029000184 Walker B; other site 592029000185 D-loop; other site 592029000186 H-loop/switch region; other site 592029000187 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 592029000188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029000189 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029000190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029000191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029000192 DNA binding residues [nucleotide binding] 592029000193 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 592029000194 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 592029000195 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 592029000196 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 592029000197 putative active site [active] 592029000198 catalytic triad [active] 592029000199 putative dimer interface [polypeptide binding]; other site 592029000200 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 592029000201 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592029000202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029000203 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592029000204 O-Antigen ligase; Region: Wzy_C; pfam04932 592029000205 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592029000206 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592029000207 DNA binding residues [nucleotide binding] 592029000208 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592029000209 Peptidase family M23; Region: Peptidase_M23; pfam01551 592029000210 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 592029000211 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 592029000212 motif 1; other site 592029000213 active site 592029000214 motif 2; other site 592029000215 motif 3; other site 592029000216 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 592029000217 Fic family protein [Function unknown]; Region: COG3177 592029000218 Fic/DOC family; Region: Fic; pfam02661 592029000219 anthranilate synthase; Provisional; Region: PRK13566 592029000220 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 592029000221 GSCFA family; Region: GSCFA; pfam08885 592029000222 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 592029000223 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 592029000224 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029000225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029000226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029000227 DNA binding residues [nucleotide binding] 592029000228 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 592029000229 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 592029000230 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 592029000231 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 592029000232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029000233 Walker A/P-loop; other site 592029000234 ATP binding site [chemical binding]; other site 592029000235 Q-loop/lid; other site 592029000236 ABC transporter signature motif; other site 592029000237 Walker B; other site 592029000238 D-loop; other site 592029000239 H-loop/switch region; other site 592029000240 ABC transporter; Region: ABC_tran_2; pfam12848 592029000241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029000242 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029000243 Repair protein; Region: Repair_PSII; pfam04536 592029000244 Repair protein; Region: Repair_PSII; pfam04536 592029000245 LemA family; Region: LemA; cl00742 592029000246 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592029000247 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592029000248 intersubunit interface [polypeptide binding]; other site 592029000249 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 592029000250 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 592029000251 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 592029000252 Penicillinase repressor; Region: Pencillinase_R; pfam03965 592029000253 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 592029000254 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000255 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 592029000256 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 592029000257 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 592029000258 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 592029000259 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592029000260 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 592029000261 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 592029000262 putative active site [active] 592029000263 putative metal binding site [ion binding]; other site 592029000264 imidazolonepropionase; Validated; Region: PRK09356 592029000265 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 592029000266 active site 592029000267 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 592029000268 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592029000269 homodimer interface [polypeptide binding]; other site 592029000270 substrate-cofactor binding pocket; other site 592029000271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029000272 catalytic residue [active] 592029000273 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 592029000274 phosphate acetyltransferase; Reviewed; Region: PRK05632 592029000275 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592029000276 DRTGG domain; Region: DRTGG; pfam07085 592029000277 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 592029000278 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 592029000279 propionate/acetate kinase; Provisional; Region: PRK12379 592029000280 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 592029000281 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_4; cd08976 592029000282 putative DNA binding site [nucleotide binding]; other site 592029000283 catalytic residue [active] 592029000284 putative H2TH interface [polypeptide binding]; other site 592029000285 putative catalytic residues [active] 592029000286 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 592029000287 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 592029000288 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 592029000289 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 592029000290 Thioesterase domain; Region: Thioesterase; pfam00975 592029000291 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 592029000292 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 592029000293 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 592029000294 active site 592029000295 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 592029000296 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 592029000297 Walker A/P-loop; other site 592029000298 ATP binding site [chemical binding]; other site 592029000299 Q-loop/lid; other site 592029000300 ABC transporter signature motif; other site 592029000301 Walker B; other site 592029000302 D-loop; other site 592029000303 H-loop/switch region; other site 592029000304 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029000305 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029000306 FtsX-like permease family; Region: FtsX; pfam02687 592029000307 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029000308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029000309 FtsX-like permease family; Region: FtsX; pfam02687 592029000310 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592029000311 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029000312 Walker A/P-loop; other site 592029000313 ATP binding site [chemical binding]; other site 592029000314 Q-loop/lid; other site 592029000315 ABC transporter signature motif; other site 592029000316 Walker B; other site 592029000317 D-loop; other site 592029000318 H-loop/switch region; other site 592029000319 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 592029000320 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592029000321 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029000322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 592029000323 Transposase; Region: DDE_Tnp_ISL3; pfam01610 592029000324 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592029000325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 592029000326 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 592029000327 Condensation domain; Region: Condensation; pfam00668 592029000328 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000329 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000330 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000331 acyl-activating enzyme (AAE) consensus motif; other site 592029000332 AMP binding site [chemical binding]; other site 592029000333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000334 Condensation domain; Region: Condensation; pfam00668 592029000335 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 592029000336 Condensation domain; Region: Condensation; pfam00668 592029000337 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000338 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000339 acyl-activating enzyme (AAE) consensus motif; other site 592029000340 AMP binding site [chemical binding]; other site 592029000341 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 592029000342 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592029000343 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000344 Condensation domain; Region: Condensation; pfam00668 592029000345 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000346 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000347 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000348 acyl-activating enzyme (AAE) consensus motif; other site 592029000349 AMP binding site [chemical binding]; other site 592029000350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000351 Condensation domain; Region: Condensation; pfam00668 592029000352 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 592029000353 Condensation domain; Region: Condensation; pfam00668 592029000354 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000355 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 592029000356 acyl-activating enzyme (AAE) consensus motif; other site 592029000357 AMP binding site [chemical binding]; other site 592029000358 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000359 Condensation domain; Region: Condensation; pfam00668 592029000360 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 592029000361 Condensation domain; Region: Condensation; pfam00668 592029000362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000364 acyl-activating enzyme (AAE) consensus motif; other site 592029000365 AMP binding site [chemical binding]; other site 592029000366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000367 Condensation domain; Region: Condensation; pfam00668 592029000368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000369 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000370 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000371 acyl-activating enzyme (AAE) consensus motif; other site 592029000372 AMP binding site [chemical binding]; other site 592029000373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000374 Condensation domain; Region: Condensation; pfam00668 592029000375 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000376 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000377 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592029000378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592029000379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000380 Condensation domain; Region: Condensation; pfam00668 592029000381 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 592029000382 Condensation domain; Region: Condensation; pfam00668 592029000383 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000384 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 592029000385 acyl-activating enzyme (AAE) consensus motif; other site 592029000386 AMP binding site [chemical binding]; other site 592029000387 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000388 Condensation domain; Region: Condensation; pfam00668 592029000389 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 592029000390 Condensation domain; Region: Condensation; pfam00668 592029000391 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000392 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000393 acyl-activating enzyme (AAE) consensus motif; other site 592029000394 AMP binding site [chemical binding]; other site 592029000395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000396 Condensation domain; Region: Condensation; pfam00668 592029000397 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000398 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000399 acyl-activating enzyme (AAE) consensus motif; other site 592029000400 AMP binding site [chemical binding]; other site 592029000401 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 592029000402 Condensation domain; Region: Condensation; pfam00668 592029000403 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000404 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000405 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000406 acyl-activating enzyme (AAE) consensus motif; other site 592029000407 AMP binding site [chemical binding]; other site 592029000408 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000409 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 592029000410 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 592029000411 active site 592029000412 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592029000413 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 592029000414 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 592029000415 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 592029000416 putative NADP binding site [chemical binding]; other site 592029000417 active site 592029000418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000419 Condensation domain; Region: Condensation; pfam00668 592029000420 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000421 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000422 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592029000423 acyl-activating enzyme (AAE) consensus motif; other site 592029000424 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 592029000425 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592029000426 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 592029000427 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000428 AMP binding site [chemical binding]; other site 592029000429 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000430 Condensation domain; Region: Condensation; pfam00668 592029000431 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000432 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000433 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 592029000434 acyl-activating enzyme (AAE) consensus motif; other site 592029000435 AMP binding site [chemical binding]; other site 592029000436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000437 Condensation domain; Region: Condensation; pfam00668 592029000438 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000439 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000440 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000441 acyl-activating enzyme (AAE) consensus motif; other site 592029000442 AMP binding site [chemical binding]; other site 592029000443 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000444 Condensation domain; Region: Condensation; pfam00668 592029000445 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000446 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000447 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000448 acyl-activating enzyme (AAE) consensus motif; other site 592029000449 AMP binding site [chemical binding]; other site 592029000450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000451 Condensation domain; Region: Condensation; pfam00668 592029000452 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000453 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000454 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000455 acyl-activating enzyme (AAE) consensus motif; other site 592029000456 AMP binding site [chemical binding]; other site 592029000457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000458 Condensation domain; Region: Condensation; pfam00668 592029000459 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000460 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000461 acyl-activating enzyme (AAE) consensus motif; other site 592029000462 AMP binding site [chemical binding]; other site 592029000463 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000464 Condensation domain; Region: Condensation; pfam00668 592029000465 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592029000466 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 592029000467 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592029000468 acyl-activating enzyme (AAE) consensus motif; other site 592029000469 AMP binding site [chemical binding]; other site 592029000470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592029000471 transcriptional activator RfaH; Region: RfaH; TIGR01955 592029000472 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 592029000473 Helix-turn-helix domain; Region: HTH_36; pfam13730 592029000474 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 592029000475 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 592029000476 catalytic residues [active] 592029000477 catalytic nucleophile [active] 592029000478 Recombinase; Region: Recombinase; pfam07508 592029000479 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 592029000480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029000481 active site 592029000482 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 592029000483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029000484 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 592029000485 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 592029000486 FMN binding site [chemical binding]; other site 592029000487 substrate binding site [chemical binding]; other site 592029000488 putative catalytic residue [active] 592029000489 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029000490 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029000491 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029000492 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 592029000493 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029000494 catalytic residues [active] 592029000495 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 592029000496 dimer interface [polypeptide binding]; other site 592029000497 FMN binding site [chemical binding]; other site 592029000498 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592029000499 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 592029000500 putative active site [active] 592029000501 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 592029000502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029000503 Ligand Binding Site [chemical binding]; other site 592029000504 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029000505 Ligand Binding Site [chemical binding]; other site 592029000506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592029000507 putative active site [active] 592029000508 heme pocket [chemical binding]; other site 592029000509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029000510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029000511 ATP binding site [chemical binding]; other site 592029000512 Mg2+ binding site [ion binding]; other site 592029000513 G-X-G motif; other site 592029000514 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592029000515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592029000516 ligand binding site [chemical binding]; other site 592029000517 flexible hinge region; other site 592029000518 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592029000519 putative switch regulator; other site 592029000520 non-specific DNA interactions [nucleotide binding]; other site 592029000521 DNA binding site [nucleotide binding] 592029000522 sequence specific DNA binding site [nucleotide binding]; other site 592029000523 putative cAMP binding site [chemical binding]; other site 592029000524 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 592029000525 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592029000526 Heavy-metal-associated domain; Region: HMA; pfam00403 592029000527 metal-binding site [ion binding] 592029000528 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592029000529 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592029000530 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 592029000531 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 592029000532 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 592029000533 Low-spin heme binding site [chemical binding]; other site 592029000534 Putative water exit pathway; other site 592029000535 Binuclear center (active site) [active] 592029000536 Putative proton exit pathway; other site 592029000537 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 592029000538 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 592029000539 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592029000540 4Fe-4S binding domain; Region: Fer4_5; pfam12801 592029000541 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 592029000542 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592029000543 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 592029000544 FixH; Region: FixH; pfam05751 592029000545 Family description; Region: DsbD_2; pfam13386 592029000546 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 592029000547 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 592029000548 active site 592029000549 Zn binding site [ion binding]; other site 592029000550 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 592029000551 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000552 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 592029000553 intersubunit interface [polypeptide binding]; other site 592029000554 active site 592029000555 catalytic residue [active] 592029000556 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 592029000557 putative active site [active] 592029000558 GIY-YIG motif/motif A; other site 592029000559 putative metal binding site [ion binding]; other site 592029000560 replicative DNA helicase; Region: DnaB; TIGR00665 592029000561 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 592029000562 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 592029000563 Walker A motif; other site 592029000564 ATP binding site [chemical binding]; other site 592029000565 Walker B motif; other site 592029000566 DNA binding loops [nucleotide binding] 592029000567 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 592029000568 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 592029000569 EamA-like transporter family; Region: EamA; pfam00892 592029000570 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592029000571 EamA-like transporter family; Region: EamA; pfam00892 592029000572 Predicted permeases [General function prediction only]; Region: COG0795 592029000573 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 592029000574 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 592029000575 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 592029000576 transketolase; Reviewed; Region: PRK05899 592029000577 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592029000578 TPP-binding site [chemical binding]; other site 592029000579 dimer interface [polypeptide binding]; other site 592029000580 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 592029000581 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592029000582 PYR/PP interface [polypeptide binding]; other site 592029000583 dimer interface [polypeptide binding]; other site 592029000584 TPP binding site [chemical binding]; other site 592029000585 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592029000586 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029000587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029000588 S-adenosylmethionine binding site [chemical binding]; other site 592029000589 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 592029000590 von Willebrand factor; Region: vWF_A; pfam12450 592029000591 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 592029000592 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 592029000593 metal ion-dependent adhesion site (MIDAS); other site 592029000594 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 592029000595 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 592029000596 23S rRNA binding site [nucleotide binding]; other site 592029000597 L21 binding site [polypeptide binding]; other site 592029000598 L13 binding site [polypeptide binding]; other site 592029000599 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 592029000600 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 592029000601 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 592029000602 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 592029000603 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 592029000604 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 592029000605 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 592029000606 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 592029000607 active site 592029000608 dimer interface [polypeptide binding]; other site 592029000609 motif 1; other site 592029000610 motif 2; other site 592029000611 motif 3; other site 592029000612 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 592029000613 anticodon binding site; other site 592029000614 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 592029000615 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592029000616 ATP binding site [chemical binding]; other site 592029000617 Mg++ binding site [ion binding]; other site 592029000618 motif III; other site 592029000619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029000620 nucleotide binding region [chemical binding]; other site 592029000621 ATP-binding site [chemical binding]; other site 592029000622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592029000623 Coenzyme A binding pocket [chemical binding]; other site 592029000624 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029000625 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029000626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592029000627 TPR motif; other site 592029000628 binding surface 592029000629 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 592029000630 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 592029000631 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 592029000632 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 592029000633 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 592029000634 CHAP domain; Region: CHAP; pfam05257 592029000635 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 592029000636 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 592029000637 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592029000638 dimer interface [polypeptide binding]; other site 592029000639 ssDNA binding site [nucleotide binding]; other site 592029000640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592029000641 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 592029000642 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 592029000643 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 592029000644 generic binding surface II; other site 592029000645 ssDNA binding site; other site 592029000646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029000647 ATP binding site [chemical binding]; other site 592029000648 putative Mg++ binding site [ion binding]; other site 592029000649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029000650 nucleotide binding region [chemical binding]; other site 592029000651 ATP-binding site [chemical binding]; other site 592029000652 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 592029000653 Part of AAA domain; Region: AAA_19; pfam13245 592029000654 Family description; Region: UvrD_C_2; pfam13538 592029000655 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029000656 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 592029000657 DNA binding residues [nucleotide binding] 592029000658 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000659 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 592029000660 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 592029000661 active site 592029000662 FMN binding site [chemical binding]; other site 592029000663 substrate binding site [chemical binding]; other site 592029000664 3Fe-4S cluster binding site [ion binding]; other site 592029000665 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 592029000666 Zn binding site [ion binding]; other site 592029000667 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029000668 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592029000669 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029000670 active site 592029000671 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029000672 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 592029000673 Sulfatase; Region: Sulfatase; cl17466 592029000674 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 592029000675 Permease; Region: Permease; pfam02405 592029000676 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 592029000677 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 592029000678 Walker A/P-loop; other site 592029000679 ATP binding site [chemical binding]; other site 592029000680 Q-loop/lid; other site 592029000681 ABC transporter signature motif; other site 592029000682 Walker B; other site 592029000683 D-loop; other site 592029000684 H-loop/switch region; other site 592029000685 voltage-gated potassium channel; Provisional; Region: PRK10537 592029000686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592029000687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029000688 salt bridge; other site 592029000689 non-specific DNA binding site [nucleotide binding]; other site 592029000690 sequence-specific DNA binding site [nucleotide binding]; other site 592029000691 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 592029000692 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592029000693 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592029000694 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 592029000695 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029000696 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029000697 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 592029000698 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 592029000699 G1 box; other site 592029000700 putative GEF interaction site [polypeptide binding]; other site 592029000701 GTP/Mg2+ binding site [chemical binding]; other site 592029000702 Switch I region; other site 592029000703 G2 box; other site 592029000704 G3 box; other site 592029000705 Switch II region; other site 592029000706 G4 box; other site 592029000707 G5 box; other site 592029000708 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 592029000709 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 592029000710 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 592029000711 Active_site [active] 592029000712 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 592029000713 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 592029000714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592029000715 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 592029000716 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 592029000717 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 592029000718 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029000719 Ligand Binding Site [chemical binding]; other site 592029000720 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029000721 Ligand Binding Site [chemical binding]; other site 592029000722 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029000723 Ligand Binding Site [chemical binding]; other site 592029000724 signal recognition particle protein; Provisional; Region: PRK10867 592029000725 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 592029000726 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592029000727 P loop; other site 592029000728 GTP binding site [chemical binding]; other site 592029000729 Signal peptide binding domain; Region: SRP_SPB; pfam02978 592029000730 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 592029000731 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 592029000732 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 592029000733 homodimer interface [polypeptide binding]; other site 592029000734 NADP binding site [chemical binding]; other site 592029000735 substrate binding site [chemical binding]; other site 592029000736 Flagellin N-methylase; Region: FliB; pfam03692 592029000737 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029000738 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029000739 catalytic residues [active] 592029000740 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 592029000741 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029000742 putative catalytic residue [active] 592029000743 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592029000744 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029000745 active site residue [active] 592029000746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029000747 active site residue [active] 592029000748 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029000749 active site residue [active] 592029000750 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029000751 active site residue [active] 592029000752 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 592029000753 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 592029000754 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 592029000755 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 592029000756 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 592029000757 active site 592029000758 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 592029000759 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 592029000760 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029000761 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 592029000762 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592029000763 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 592029000764 protein binding site [polypeptide binding]; other site 592029000765 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 592029000766 Domain interface; other site 592029000767 Peptide binding site; other site 592029000768 Active site tetrad [active] 592029000769 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 592029000770 Transcriptional regulators [Transcription]; Region: MarR; COG1846 592029000771 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 592029000772 Inner membrane protein CreD; Region: CreD; pfam06123 592029000773 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 592029000774 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 592029000775 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 592029000776 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 592029000777 legume lectins; Region: lectin_L-type; cd01951 592029000778 homotetramer interaction site [polypeptide binding]; other site 592029000779 carbohydrate binding site [chemical binding]; other site 592029000780 metal binding site [ion binding]; metal-binding site 592029000781 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029000782 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 592029000783 active site 592029000784 ligand binding site [chemical binding]; other site 592029000785 NAD(P) binding site [chemical binding]; other site 592029000786 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592029000787 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592029000788 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592029000789 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 592029000790 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 592029000791 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592029000792 classical (c) SDRs; Region: SDR_c; cd05233 592029000793 NAD(P) binding site [chemical binding]; other site 592029000794 active site 592029000795 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 592029000796 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 592029000797 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 592029000798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592029000799 EamA-like transporter family; Region: EamA; pfam00892 592029000800 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 592029000801 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 592029000802 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 592029000803 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 592029000804 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 592029000805 starch binding outer membrane protein SusD; Region: SusD; cd08977 592029000806 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029000807 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029000808 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029000809 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 592029000810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029000811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029000812 dimer interface [polypeptide binding]; other site 592029000813 phosphorylation site [posttranslational modification] 592029000814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029000815 ATP binding site [chemical binding]; other site 592029000816 Mg2+ binding site [ion binding]; other site 592029000817 G-X-G motif; other site 592029000818 Response regulator receiver domain; Region: Response_reg; pfam00072 592029000819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029000820 active site 592029000821 phosphorylation site [posttranslational modification] 592029000822 intermolecular recognition site; other site 592029000823 dimerization interface [polypeptide binding]; other site 592029000824 Helix-turn-helix domain; Region: HTH_18; pfam12833 592029000825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029000826 D-mannonate oxidoreductase; Provisional; Region: PRK08277 592029000827 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 592029000828 putative NAD(P) binding site [chemical binding]; other site 592029000829 active site 592029000830 mannonate dehydratase; Region: uxuA; TIGR00695 592029000831 mannonate dehydratase; Provisional; Region: PRK03906 592029000832 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 592029000833 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 592029000834 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 592029000835 NADP binding site [chemical binding]; other site 592029000836 homodimer interface [polypeptide binding]; other site 592029000837 active site 592029000838 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 592029000839 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 592029000840 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 592029000841 DctM-like transporters; Region: DctM; pfam06808 592029000842 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 592029000843 Glucuronate isomerase; Region: UxaC; pfam02614 592029000844 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 592029000845 Alginate lyase; Region: Alginate_lyase2; pfam08787 592029000846 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 592029000847 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 592029000848 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 592029000849 Lamin Tail Domain; Region: LTD; pfam00932 592029000850 Lamin Tail Domain; Region: LTD; pfam00932 592029000851 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000852 Lamin Tail Domain; Region: LTD; pfam00932 592029000853 Lamin Tail Domain; Region: LTD; pfam00932 592029000854 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000855 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 592029000856 Right handed beta helix region; Region: Beta_helix; pfam13229 592029000857 starch binding outer membrane protein SusD; Region: SusD; cd08977 592029000858 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029000859 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029000860 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592029000861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592029000862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592029000863 DNA-binding site [nucleotide binding]; DNA binding site 592029000864 FCD domain; Region: FCD; pfam07729 592029000865 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 592029000866 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 592029000867 active site 592029000868 intersubunit interface [polypeptide binding]; other site 592029000869 catalytic residue [active] 592029000870 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592029000871 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592029000872 substrate binding site [chemical binding]; other site 592029000873 ATP binding site [chemical binding]; other site 592029000874 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 592029000875 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592029000876 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 592029000877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029000878 catalytic residue [active] 592029000879 Smr domain; Region: Smr; cl02619 592029000880 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000881 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 592029000882 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 592029000883 Interferon-induced transmembrane protein; Region: CD225; pfam04505 592029000884 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 592029000885 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592029000886 inhibitor-cofactor binding pocket; inhibition site 592029000887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029000888 catalytic residue [active] 592029000889 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 592029000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029000891 S-adenosylmethionine binding site [chemical binding]; other site 592029000892 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029000893 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029000894 catalytic residues [active] 592029000895 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 592029000896 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 592029000897 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000898 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 592029000899 active site 592029000900 catalytic residues [active] 592029000901 metal binding site [ion binding]; metal-binding site 592029000902 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 592029000903 four helix bundle protein; Region: TIGR02436 592029000904 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 592029000905 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 592029000906 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 592029000907 trimer interface [polypeptide binding]; other site 592029000908 active site 592029000909 substrate binding site [chemical binding]; other site 592029000910 CoA binding site [chemical binding]; other site 592029000911 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592029000912 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029000913 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029000914 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 592029000915 Substrate binding site; other site 592029000916 metal-binding site 592029000917 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029000918 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 592029000919 putative metal binding site; other site 592029000920 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 592029000921 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 592029000922 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 592029000923 Probable Catalytic site; other site 592029000924 metal-binding site 592029000925 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029000926 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592029000927 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 592029000928 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 592029000929 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 592029000930 active site 592029000931 NTP binding site [chemical binding]; other site 592029000932 metal binding triad [ion binding]; metal-binding site 592029000933 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 592029000934 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029000935 Zn2+ binding site [ion binding]; other site 592029000936 Mg2+ binding site [ion binding]; other site 592029000937 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 592029000938 Histidine kinase; Region: His_kinase; pfam06580 592029000939 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029000940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029000941 active site 592029000942 phosphorylation site [posttranslational modification] 592029000943 intermolecular recognition site; other site 592029000944 dimerization interface [polypeptide binding]; other site 592029000945 LytTr DNA-binding domain; Region: LytTR; smart00850 592029000946 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029000947 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029000948 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000949 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 592029000950 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 592029000951 Histidine kinase; Region: His_kinase; pfam06580 592029000952 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029000953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029000954 active site 592029000955 phosphorylation site [posttranslational modification] 592029000956 intermolecular recognition site; other site 592029000957 dimerization interface [polypeptide binding]; other site 592029000958 LytTr DNA-binding domain; Region: LytTR; smart00850 592029000959 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029000960 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029000961 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 592029000962 peptidase T; Region: peptidase-T; TIGR01882 592029000963 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 592029000964 metal binding site [ion binding]; metal-binding site 592029000965 dimer interface [polypeptide binding]; other site 592029000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 592029000967 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 592029000968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 592029000969 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 592029000970 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 592029000971 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 592029000972 putative hydrophobic ligand binding site [chemical binding]; other site 592029000973 Preprotein translocase subunit; Region: YajC; pfam02699 592029000974 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 592029000975 transcription antitermination factor NusB; Region: nusB; TIGR01951 592029000976 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592029000977 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 592029000978 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 592029000979 NAD binding site [chemical binding]; other site 592029000980 Phe binding site; other site 592029000981 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592029000982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592029000983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029000984 Walker A/P-loop; other site 592029000985 ATP binding site [chemical binding]; other site 592029000986 Q-loop/lid; other site 592029000987 ABC transporter signature motif; other site 592029000988 Walker B; other site 592029000989 D-loop; other site 592029000990 H-loop/switch region; other site 592029000991 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 592029000992 putative active site [active] 592029000993 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 592029000994 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 592029000995 putative active site [active] 592029000996 Zn binding site [ion binding]; other site 592029000997 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 592029000998 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 592029000999 dimer interface [polypeptide binding]; other site 592029001000 putative tRNA-binding site [nucleotide binding]; other site 592029001001 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 592029001002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029001003 putative catalytic residue [active] 592029001004 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 592029001005 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 592029001006 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 592029001007 heterodimerization interface [polypeptide binding]; other site 592029001008 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 592029001009 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 592029001010 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 592029001011 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 592029001012 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 592029001013 Protein export membrane protein; Region: SecD_SecF; pfam02355 592029001014 malate dehydrogenase; Reviewed; Region: PRK06223 592029001015 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 592029001016 dimer interface [polypeptide binding]; other site 592029001017 NAD(P) binding site [chemical binding]; other site 592029001018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592029001019 substrate binding site [chemical binding]; other site 592029001020 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 592029001021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001022 ATP binding site [chemical binding]; other site 592029001023 Mg2+ binding site [ion binding]; other site 592029001024 G-X-G motif; other site 592029001025 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 592029001026 anchoring element; other site 592029001027 dimer interface [polypeptide binding]; other site 592029001028 ATP binding site [chemical binding]; other site 592029001029 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 592029001030 active site 592029001031 putative metal-binding site [ion binding]; other site 592029001032 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592029001033 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 592029001034 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 592029001035 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 592029001036 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 592029001037 Zonular occludens toxin (Zot); Region: Zot; cl17485 592029001038 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 592029001039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029001040 nucleophilic elbow; other site 592029001041 catalytic triad; other site 592029001042 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 592029001043 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592029001044 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592029001045 Clp protease; Region: CLP_protease; pfam00574 592029001046 oligomer interface [polypeptide binding]; other site 592029001047 active site residues [active] 592029001048 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 592029001049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592029001050 putative metal binding site [ion binding]; other site 592029001051 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029001052 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 592029001053 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029001054 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592029001055 Uncharacterized conserved protein [Function unknown]; Region: COG3339 592029001056 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 592029001057 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 592029001058 active site 592029001059 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029001060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029001061 binding surface 592029001062 TPR motif; other site 592029001063 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 592029001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029001065 TPR motif; other site 592029001066 binding surface 592029001067 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 592029001068 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 592029001069 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 592029001070 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 592029001071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029001072 binding surface 592029001073 TPR motif; other site 592029001074 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 592029001075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029001076 Walker A/P-loop; other site 592029001077 ATP binding site [chemical binding]; other site 592029001078 Q-loop/lid; other site 592029001079 ABC transporter signature motif; other site 592029001080 Walker B; other site 592029001081 D-loop; other site 592029001082 H-loop/switch region; other site 592029001083 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 592029001084 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029001085 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 592029001086 active site 592029001087 WxcM-like, C-terminal; Region: FdtA; pfam05523 592029001088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029001089 active site 592029001090 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029001091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029001092 Fic family protein [Function unknown]; Region: COG3177 592029001093 Fic/DOC family; Region: Fic; pfam02661 592029001094 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 592029001095 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592029001096 E3 interaction surface; other site 592029001097 lipoyl attachment site [posttranslational modification]; other site 592029001098 e3 binding domain; Region: E3_binding; pfam02817 592029001099 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592029001100 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592029001101 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 592029001102 Probable Catalytic site; other site 592029001103 metal-binding site 592029001104 recombination protein RecR; Reviewed; Region: recR; PRK00076 592029001105 RecR protein; Region: RecR; pfam02132 592029001106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 592029001107 putative active site [active] 592029001108 putative metal-binding site [ion binding]; other site 592029001109 tetramer interface [polypeptide binding]; other site 592029001110 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 592029001111 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 592029001112 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 592029001113 dihydropteroate synthase; Region: DHPS; TIGR01496 592029001114 substrate binding pocket [chemical binding]; other site 592029001115 dimer interface [polypeptide binding]; other site 592029001116 inhibitor binding site; inhibition site 592029001117 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 592029001118 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 592029001119 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 592029001120 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 592029001121 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 592029001122 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592029001123 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592029001124 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 592029001125 Walker A/P-loop; other site 592029001126 ATP binding site [chemical binding]; other site 592029001127 Q-loop/lid; other site 592029001128 ABC transporter signature motif; other site 592029001129 Walker B; other site 592029001130 D-loop; other site 592029001131 H-loop/switch region; other site 592029001132 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 592029001133 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 592029001134 dimerization interface 3.5A [polypeptide binding]; other site 592029001135 active site 592029001136 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 592029001137 active site 592029001138 metal binding site [ion binding]; metal-binding site 592029001139 homotetramer interface [polypeptide binding]; other site 592029001140 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 592029001141 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 592029001142 transcription termination factor Rho; Provisional; Region: PRK12608 592029001143 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 592029001144 RNA binding site [nucleotide binding]; other site 592029001145 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 592029001146 multimer interface [polypeptide binding]; other site 592029001147 Walker A motif; other site 592029001148 ATP binding site [chemical binding]; other site 592029001149 Walker B motif; other site 592029001150 AAA domain; Region: AAA_13; pfam13166 592029001151 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 592029001152 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592029001153 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592029001154 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592029001155 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592029001156 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592029001157 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592029001158 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 592029001159 Fasciclin domain; Region: Fasciclin; pfam02469 592029001160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 592029001161 Homeodomain-like domain; Region: HTH_23; pfam13384 592029001162 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 592029001163 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 592029001164 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 592029001165 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 592029001166 Na binding site [ion binding]; other site 592029001167 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 592029001168 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592029001169 Na binding site [ion binding]; other site 592029001170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029001171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029001172 dimer interface [polypeptide binding]; other site 592029001173 phosphorylation site [posttranslational modification] 592029001174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001175 ATP binding site [chemical binding]; other site 592029001176 Mg2+ binding site [ion binding]; other site 592029001177 G-X-G motif; other site 592029001178 Response regulator receiver domain; Region: Response_reg; pfam00072 592029001179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029001180 active site 592029001181 phosphorylation site [posttranslational modification] 592029001182 intermolecular recognition site; other site 592029001183 dimerization interface [polypeptide binding]; other site 592029001184 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 592029001185 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 592029001186 acyl-activating enzyme (AAE) consensus motif; other site 592029001187 putative AMP binding site [chemical binding]; other site 592029001188 putative active site [active] 592029001189 putative CoA binding site [chemical binding]; other site 592029001190 acetyl-CoA synthetase; Provisional; Region: PRK00174 592029001191 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 592029001192 active site 592029001193 CoA binding site [chemical binding]; other site 592029001194 acyl-activating enzyme (AAE) consensus motif; other site 592029001195 AMP binding site [chemical binding]; other site 592029001196 acetate binding site [chemical binding]; other site 592029001197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592029001198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592029001199 short chain dehydrogenase; Provisional; Region: PRK12744 592029001200 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 592029001201 NADP binding site [chemical binding]; other site 592029001202 homodimer interface [polypeptide binding]; other site 592029001203 active site 592029001204 substrate binding site [chemical binding]; other site 592029001205 SnoaL-like domain; Region: SnoaL_2; pfam12680 592029001206 Ion channel; Region: Ion_trans_2; pfam07885 592029001207 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 592029001208 Predicted acetyltransferase [General function prediction only]; Region: COG2388 592029001209 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592029001210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029001211 non-specific DNA binding site [nucleotide binding]; other site 592029001212 salt bridge; other site 592029001213 sequence-specific DNA binding site [nucleotide binding]; other site 592029001214 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029001215 Conserved TM helix; Region: TM_helix; pfam05552 592029001216 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029001217 GldM N-terminal domain; Region: GldM_N; pfam12081 592029001218 GTPase Era; Reviewed; Region: era; PRK00089 592029001219 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 592029001220 G1 box; other site 592029001221 GTP/Mg2+ binding site [chemical binding]; other site 592029001222 Switch I region; other site 592029001223 G2 box; other site 592029001224 Switch II region; other site 592029001225 G3 box; other site 592029001226 G4 box; other site 592029001227 G5 box; other site 592029001228 KH domain; Region: KH_2; pfam07650 592029001229 Anti-sigma-K factor rskA; Region: RskA; pfam10099 592029001230 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 592029001231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029001232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029001233 DNA binding residues [nucleotide binding] 592029001234 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 592029001235 Fasciclin domain; Region: Fasciclin; pfam02469 592029001236 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592029001237 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 592029001238 Walker A/P-loop; other site 592029001239 ATP binding site [chemical binding]; other site 592029001240 Q-loop/lid; other site 592029001241 ABC transporter signature motif; other site 592029001242 Walker B; other site 592029001243 D-loop; other site 592029001244 H-loop/switch region; other site 592029001245 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 592029001246 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592029001247 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592029001248 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 592029001249 Zn binding site [ion binding]; other site 592029001250 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 592029001251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029001252 NAD(P) binding site [chemical binding]; other site 592029001253 active site 592029001254 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 592029001255 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 592029001256 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 592029001257 Amidinotransferase; Region: Amidinotransf; pfam02274 592029001258 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 592029001259 Amidinotransferase; Region: Amidinotransf; cl12043 592029001260 PrcB C-terminal; Region: PrcB_C; pfam14343 592029001261 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 592029001262 dimer interface [polypeptide binding]; other site 592029001263 Citrate synthase; Region: Citrate_synt; pfam00285 592029001264 active site 592029001265 citrylCoA binding site [chemical binding]; other site 592029001266 NADH binding [chemical binding]; other site 592029001267 cationic pore residues; other site 592029001268 oxalacetate/citrate binding site [chemical binding]; other site 592029001269 coenzyme A binding site [chemical binding]; other site 592029001270 catalytic triad [active] 592029001271 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 592029001272 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 592029001273 POT family; Region: PTR2; cl17359 592029001274 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029001275 enolase; Provisional; Region: eno; PRK00077 592029001276 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 592029001277 dimer interface [polypeptide binding]; other site 592029001278 metal binding site [ion binding]; metal-binding site 592029001279 substrate binding pocket [chemical binding]; other site 592029001280 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 592029001281 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 592029001282 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 592029001283 catalytic site [active] 592029001284 subunit interface [polypeptide binding]; other site 592029001285 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 592029001286 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 592029001287 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 592029001288 alphaNTD homodimer interface [polypeptide binding]; other site 592029001289 alphaNTD - beta interaction site [polypeptide binding]; other site 592029001290 alphaNTD - beta' interaction site [polypeptide binding]; other site 592029001291 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 592029001292 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 592029001293 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 592029001294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592029001295 RNA binding surface [nucleotide binding]; other site 592029001296 30S ribosomal protein S11; Validated; Region: PRK05309 592029001297 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 592029001298 30S ribosomal protein S13; Region: bact_S13; TIGR03631 592029001299 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 592029001300 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 592029001301 rRNA binding site [nucleotide binding]; other site 592029001302 predicted 30S ribosome binding site; other site 592029001303 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 592029001304 SecY translocase; Region: SecY; pfam00344 592029001305 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 592029001306 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 592029001307 23S rRNA binding site [nucleotide binding]; other site 592029001308 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 592029001309 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 592029001310 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 592029001311 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 592029001312 5S rRNA interface [nucleotide binding]; other site 592029001313 23S rRNA interface [nucleotide binding]; other site 592029001314 L5 interface [polypeptide binding]; other site 592029001315 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 592029001316 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592029001317 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592029001318 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 592029001319 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 592029001320 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 592029001321 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 592029001322 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 592029001323 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 592029001324 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 592029001325 RNA binding site [nucleotide binding]; other site 592029001326 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 592029001327 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 592029001328 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 592029001329 23S rRNA interface [nucleotide binding]; other site 592029001330 putative translocon interaction site; other site 592029001331 signal recognition particle (SRP54) interaction site; other site 592029001332 L23 interface [polypeptide binding]; other site 592029001333 trigger factor interaction site; other site 592029001334 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 592029001335 23S rRNA interface [nucleotide binding]; other site 592029001336 5S rRNA interface [nucleotide binding]; other site 592029001337 putative antibiotic binding site [chemical binding]; other site 592029001338 L25 interface [polypeptide binding]; other site 592029001339 L27 interface [polypeptide binding]; other site 592029001340 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 592029001341 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 592029001342 G-X-X-G motif; other site 592029001343 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 592029001344 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 592029001345 putative translocon binding site; other site 592029001346 protein-rRNA interface [nucleotide binding]; other site 592029001347 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 592029001348 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 592029001349 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 592029001350 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 592029001351 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 592029001352 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 592029001353 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 592029001354 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 592029001355 elongation factor G; Reviewed; Region: PRK12739 592029001356 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 592029001357 G1 box; other site 592029001358 putative GEF interaction site [polypeptide binding]; other site 592029001359 GTP/Mg2+ binding site [chemical binding]; other site 592029001360 Switch I region; other site 592029001361 G2 box; other site 592029001362 G3 box; other site 592029001363 Switch II region; other site 592029001364 G4 box; other site 592029001365 G5 box; other site 592029001366 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 592029001367 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 592029001368 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 592029001369 30S ribosomal protein S7; Validated; Region: PRK05302 592029001370 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 592029001371 S17 interaction site [polypeptide binding]; other site 592029001372 S8 interaction site; other site 592029001373 16S rRNA interaction site [nucleotide binding]; other site 592029001374 streptomycin interaction site [chemical binding]; other site 592029001375 23S rRNA interaction site [nucleotide binding]; other site 592029001376 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 592029001377 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029001378 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029001379 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029001380 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 592029001381 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029001382 starch binding outer membrane protein SusD; Region: SusD; cd08977 592029001383 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 592029001384 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 592029001385 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 592029001386 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592029001387 Rhomboid family; Region: Rhomboid; cl11446 592029001388 recombination factor protein RarA; Reviewed; Region: PRK13342 592029001389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029001390 Walker A motif; other site 592029001391 ATP binding site [chemical binding]; other site 592029001392 Walker B motif; other site 592029001393 arginine finger; other site 592029001394 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 592029001395 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 592029001396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029001397 motif II; other site 592029001398 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 592029001399 hypothetical protein; Reviewed; Region: PRK00024 592029001400 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 592029001401 MPN+ (JAMM) motif; other site 592029001402 Zinc-binding site [ion binding]; other site 592029001403 hypothetical protein; Validated; Region: PRK02101 592029001404 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592029001405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592029001406 RNA binding surface [nucleotide binding]; other site 592029001407 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592029001408 active site 592029001409 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 592029001410 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 592029001411 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 592029001412 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 592029001413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592029001414 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 592029001415 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 592029001416 active site 592029001417 (T/H)XGH motif; other site 592029001418 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 592029001419 putative active site [active] 592029001420 Zn binding site [ion binding]; other site 592029001421 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 592029001422 active site 592029001423 Ap6A binding site [chemical binding]; other site 592029001424 nudix motif; other site 592029001425 metal binding site [ion binding]; metal-binding site 592029001426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029001427 active site 592029001428 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 592029001429 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 592029001430 Oligomerisation domain; Region: Oligomerisation; pfam02410 592029001431 FtsH Extracellular; Region: FtsH_ext; pfam06480 592029001432 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 592029001433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029001434 Walker A motif; other site 592029001435 ATP binding site [chemical binding]; other site 592029001436 Walker B motif; other site 592029001437 arginine finger; other site 592029001438 Peptidase family M41; Region: Peptidase_M41; pfam01434 592029001439 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 592029001440 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 592029001441 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 592029001442 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 592029001443 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 592029001444 acyl-CoA binding pocket [chemical binding]; other site 592029001445 CoA binding site [chemical binding]; other site 592029001446 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 592029001447 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029001448 active site 592029001449 HIGH motif; other site 592029001450 nucleotide binding site [chemical binding]; other site 592029001451 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592029001452 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 592029001453 active site 592029001454 KMSKS motif; other site 592029001455 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 592029001456 tRNA binding surface [nucleotide binding]; other site 592029001457 anticodon binding site; other site 592029001458 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 592029001459 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 592029001460 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 592029001461 catalytic motif [active] 592029001462 Catalytic residue [active] 592029001463 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 592029001464 aspartate aminotransferase; Provisional; Region: PRK07568 592029001465 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592029001466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029001467 homodimer interface [polypeptide binding]; other site 592029001468 catalytic residue [active] 592029001469 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 592029001470 FAD binding domain; Region: FAD_binding_4; pfam01565 592029001471 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 592029001472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029001473 active site 592029001474 lipoyl synthase; Provisional; Region: PRK05481 592029001475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592029001476 FeS/SAM binding site; other site 592029001477 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 592029001478 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 592029001479 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592029001480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029001481 dimer interface [polypeptide binding]; other site 592029001482 phosphorylation site [posttranslational modification] 592029001483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001484 ATP binding site [chemical binding]; other site 592029001485 Mg2+ binding site [ion binding]; other site 592029001486 G-X-G motif; other site 592029001487 Response regulator receiver domain; Region: Response_reg; pfam00072 592029001488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029001489 active site 592029001490 phosphorylation site [posttranslational modification] 592029001491 intermolecular recognition site; other site 592029001492 dimerization interface [polypeptide binding]; other site 592029001493 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 592029001494 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 592029001495 Uncharacterized conserved protein [Function unknown]; Region: COG0327 592029001496 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 592029001497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 592029001498 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 592029001499 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 592029001500 Putative zinc ribbon domain; Region: DUF164; pfam02591 592029001501 methionine sulfoxide reductase A; Provisional; Region: PRK14054 592029001502 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 592029001503 asparagine synthetase B; Provisional; Region: asnB; PRK09431 592029001504 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 592029001505 active site 592029001506 dimer interface [polypeptide binding]; other site 592029001507 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 592029001508 Ligand Binding Site [chemical binding]; other site 592029001509 Molecular Tunnel; other site 592029001510 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 592029001511 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592029001512 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592029001513 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 592029001514 Glutamine amidotransferase class-I; Region: GATase; pfam00117 592029001515 glutamine binding [chemical binding]; other site 592029001516 catalytic triad [active] 592029001517 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 592029001518 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592029001519 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592029001520 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 592029001521 active site 592029001522 ribulose/triose binding site [chemical binding]; other site 592029001523 phosphate binding site [ion binding]; other site 592029001524 substrate (anthranilate) binding pocket [chemical binding]; other site 592029001525 product (indole) binding pocket [chemical binding]; other site 592029001526 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 592029001527 active site 592029001528 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 592029001529 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 592029001530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029001531 catalytic residue [active] 592029001532 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 592029001533 substrate binding site [chemical binding]; other site 592029001534 active site 592029001535 catalytic residues [active] 592029001536 heterodimer interface [polypeptide binding]; other site 592029001537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029001538 AAA domain; Region: AAA_22; pfam13401 592029001539 Walker A motif; other site 592029001540 ATP binding site [chemical binding]; other site 592029001541 Walker B motif; other site 592029001542 arginine finger; other site 592029001543 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 592029001544 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 592029001545 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 592029001546 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 592029001547 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 592029001548 histidinol dehydrogenase; Region: hisD; TIGR00069 592029001549 NAD binding site [chemical binding]; other site 592029001550 dimerization interface [polypeptide binding]; other site 592029001551 product binding site; other site 592029001552 substrate binding site [chemical binding]; other site 592029001553 zinc binding site [ion binding]; other site 592029001554 catalytic residues [active] 592029001555 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 592029001556 putative active site [active] 592029001557 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 592029001558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592029001559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029001560 homodimer interface [polypeptide binding]; other site 592029001561 catalytic residue [active] 592029001562 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 592029001563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029001564 active site 592029001565 motif I; other site 592029001566 motif II; other site 592029001567 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 592029001568 putative active site pocket [active] 592029001569 4-fold oligomerization interface [polypeptide binding]; other site 592029001570 metal binding residues [ion binding]; metal-binding site 592029001571 3-fold/trimer interface [polypeptide binding]; other site 592029001572 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 592029001573 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 592029001574 putative active site [active] 592029001575 oxyanion strand; other site 592029001576 catalytic triad [active] 592029001577 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 592029001578 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 592029001579 catalytic residues [active] 592029001580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592029001581 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592029001582 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 592029001583 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 592029001584 substrate binding site [chemical binding]; other site 592029001585 glutamase interaction surface [polypeptide binding]; other site 592029001586 PIN domain; Region: PIN_3; pfam13470 592029001587 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 592029001588 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 592029001589 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 592029001590 metal binding site [ion binding]; metal-binding site 592029001591 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 592029001592 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592029001593 FMN binding site [chemical binding]; other site 592029001594 active site 592029001595 substrate binding site [chemical binding]; other site 592029001596 catalytic residue [active] 592029001597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592029001598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592029001599 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 592029001600 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 592029001601 cofactor binding site; other site 592029001602 metal binding site [ion binding]; metal-binding site 592029001603 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 592029001604 ATP binding site [chemical binding]; other site 592029001605 Mg2+ binding site [ion binding]; other site 592029001606 G-X-G motif; other site 592029001607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001608 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029001611 Histidine kinase; Region: HisKA_3; pfam07730 592029001612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001613 ATP binding site [chemical binding]; other site 592029001614 Mg2+ binding site [ion binding]; other site 592029001615 G-X-G motif; other site 592029001616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029001617 TPR motif; other site 592029001618 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001619 binding surface 592029001620 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029001623 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 592029001624 Histidine kinase; Region: HisKA_3; pfam07730 592029001625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001626 ATP binding site [chemical binding]; other site 592029001627 Mg2+ binding site [ion binding]; other site 592029001628 G-X-G motif; other site 592029001629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029001631 active site 592029001632 phosphorylation site [posttranslational modification] 592029001633 intermolecular recognition site; other site 592029001634 dimerization interface [polypeptide binding]; other site 592029001635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029001636 DNA binding residues [nucleotide binding] 592029001637 dimerization interface [polypeptide binding]; other site 592029001638 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 592029001639 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 592029001640 active site 592029001641 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 592029001642 active site 592029001643 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029001644 active site residue [active] 592029001645 Helix-turn-helix domain; Region: HTH_18; pfam12833 592029001646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029001647 Uncharacterized conserved protein [Function unknown]; Region: COG2128 592029001648 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592029001649 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 592029001650 nudix motif; other site 592029001651 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 592029001652 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 592029001653 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 592029001654 active site 592029001655 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 592029001656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029001657 active site 592029001658 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 592029001659 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 592029001660 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592029001661 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 592029001662 active site 592029001663 metal binding site [ion binding]; metal-binding site 592029001664 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 592029001665 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 592029001666 putative ADP-ribose binding site [chemical binding]; other site 592029001667 putative active site [active] 592029001668 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 592029001669 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 592029001670 Asp-box motif; other site 592029001671 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 592029001672 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 592029001673 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 592029001674 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 592029001675 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 592029001676 G1 box; other site 592029001677 GTP/Mg2+ binding site [chemical binding]; other site 592029001678 G2 box; other site 592029001679 Switch I region; other site 592029001680 G3 box; other site 592029001681 Switch II region; other site 592029001682 TIR domain; Region: TIR_2; pfam13676 592029001683 Tellurite resistance protein TerB; Region: TerB; cl17311 592029001684 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029001685 Ligand Binding Site [chemical binding]; other site 592029001686 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029001687 Ligand Binding Site [chemical binding]; other site 592029001688 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 592029001689 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 592029001690 catalytic residues [active] 592029001691 catalytic nucleophile [active] 592029001692 Recombinase; Region: Recombinase; pfam07508 592029001693 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592029001694 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 592029001695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029001696 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029001697 Methyltransferase domain; Region: Methyltransf_26; pfam13659 592029001698 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 592029001699 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 592029001700 Helicase_C-like; Region: Helicase_C_4; pfam13871 592029001701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029001702 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592029001703 Walker A motif; other site 592029001704 ATP binding site [chemical binding]; other site 592029001705 Walker B motif; other site 592029001706 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 592029001707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029001708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029001709 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592029001710 MerT mercuric transport protein; Region: MerT; cl03578 592029001711 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592029001712 metal-binding site [ion binding] 592029001713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592029001714 dimerization interface [polypeptide binding]; other site 592029001715 putative DNA binding site [nucleotide binding]; other site 592029001716 putative Zn2+ binding site [ion binding]; other site 592029001717 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 592029001718 active site 592029001719 NTP binding site [chemical binding]; other site 592029001720 metal binding triad [ion binding]; metal-binding site 592029001721 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 592029001722 Predicted ATPase [General function prediction only]; Region: COG4637 592029001723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029001724 Walker A/P-loop; other site 592029001725 ATP binding site [chemical binding]; other site 592029001726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 592029001727 ABC transporter signature motif; other site 592029001728 Walker B; other site 592029001729 D-loop; other site 592029001730 H-loop/switch region; other site 592029001731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029001732 non-specific DNA binding site [nucleotide binding]; other site 592029001733 salt bridge; other site 592029001734 sequence-specific DNA binding site [nucleotide binding]; other site 592029001735 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 592029001736 DnaA box-binding interface [nucleotide binding]; other site 592029001737 Zonular occludens toxin (Zot); Region: Zot; cl17485 592029001738 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 592029001739 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 592029001740 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 592029001741 TIGR02594 family protein; Region: TIGR02594 592029001742 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 592029001743 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592029001744 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592029001745 Peptidase M15; Region: Peptidase_M15_3; cl01194 592029001746 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 592029001747 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 592029001748 Outer membrane efflux protein; Region: OEP; pfam02321 592029001749 Outer membrane efflux protein; Region: OEP; pfam02321 592029001750 Helix-turn-helix domain; Region: HTH_18; pfam12833 592029001751 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 592029001752 Multicopper oxidase; Region: Cu-oxidase; pfam00394 592029001753 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 592029001754 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 592029001755 Haem-binding domain; Region: Haem_bd; pfam14376 592029001756 Ion channel; Region: Ion_trans_2; pfam07885 592029001757 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592029001758 metal-binding site [ion binding] 592029001759 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592029001760 metal-binding site [ion binding] 592029001761 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 592029001762 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592029001763 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592029001764 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 592029001765 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 592029001766 Domain of unknown function (DUF305); Region: DUF305; cl17794 592029001767 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592029001768 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029001769 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592029001770 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 592029001771 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 592029001772 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 592029001773 HlyD family secretion protein; Region: HlyD_2; pfam12700 592029001774 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029001775 putative membrane fusion protein; Region: TIGR02828 592029001776 Cation efflux family; Region: Cation_efflux; cl00316 592029001777 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 592029001778 metal binding site 2 [ion binding]; metal-binding site 592029001779 putative DNA binding helix; other site 592029001780 metal binding site 1 [ion binding]; metal-binding site 592029001781 dimer interface [polypeptide binding]; other site 592029001782 structural Zn2+ binding site [ion binding]; other site 592029001783 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 592029001784 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 592029001785 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592029001786 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592029001787 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029001788 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029001789 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 592029001790 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 592029001791 30S subunit binding site; other site 592029001792 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 592029001793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029001794 dimer interface [polypeptide binding]; other site 592029001795 phosphorylation site [posttranslational modification] 592029001796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001797 ATP binding site [chemical binding]; other site 592029001798 Mg2+ binding site [ion binding]; other site 592029001799 G-X-G motif; other site 592029001800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029001801 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 592029001802 active site 592029001803 phosphorylation site [posttranslational modification] 592029001804 intermolecular recognition site; other site 592029001805 dimerization interface [polypeptide binding]; other site 592029001806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029001807 Walker A motif; other site 592029001808 ATP binding site [chemical binding]; other site 592029001809 Walker B motif; other site 592029001810 arginine finger; other site 592029001811 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592029001812 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 592029001813 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592029001814 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 592029001815 NAD(P) binding site [chemical binding]; other site 592029001816 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592029001817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029001818 YHYH protein; Region: YHYH; pfam14240 592029001819 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315 592029001820 YHYH protein; Region: YHYH; pfam14240 592029001821 YHYH protein; Region: YHYH; pfam14240 592029001822 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 592029001823 pseudo EF-hand loop; other site 592029001824 peptide binding pocket; other site 592029001825 Ca2+ binding site [ion binding]; other site 592029001826 YHYH protein; Region: YHYH; pfam14240 592029001827 Histidine kinase; Region: His_kinase; pfam06580 592029001828 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 592029001829 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029001830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029001831 active site 592029001832 phosphorylation site [posttranslational modification] 592029001833 intermolecular recognition site; other site 592029001834 dimerization interface [polypeptide binding]; other site 592029001835 LytTr DNA-binding domain; Region: LytTR; smart00850 592029001836 Sulphur transport; Region: Sulf_transp; pfam04143 592029001837 Sulphur transport; Region: Sulf_transp; pfam04143 592029001838 Predicted transporter component [General function prediction only]; Region: COG2391 592029001839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592029001840 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029001841 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 592029001842 active site residue [active] 592029001843 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592029001844 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592029001845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592029001846 ligand binding site [chemical binding]; other site 592029001847 flexible hinge region; other site 592029001848 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592029001849 putative switch regulator; other site 592029001850 non-specific DNA interactions [nucleotide binding]; other site 592029001851 DNA binding site [nucleotide binding] 592029001852 sequence specific DNA binding site [nucleotide binding]; other site 592029001853 putative cAMP binding site [chemical binding]; other site 592029001854 Domain of unknown function (DUF897); Region: DUF897; pfam05982 592029001855 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592029001856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592029001857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592029001858 dimerization interface [polypeptide binding]; other site 592029001859 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029001860 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029001861 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029001862 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 592029001863 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 592029001864 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 592029001865 trimer interface [polypeptide binding]; other site 592029001866 active site 592029001867 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 592029001868 catalytic site [active] 592029001869 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 592029001870 glycogen branching enzyme; Provisional; Region: PRK12313 592029001871 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 592029001872 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 592029001873 active site 592029001874 catalytic site [active] 592029001875 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 592029001876 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 592029001877 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 592029001878 ligand binding site; other site 592029001879 oligomer interface; other site 592029001880 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 592029001881 dimer interface [polypeptide binding]; other site 592029001882 N-terminal domain interface [polypeptide binding]; other site 592029001883 sulfate 1 binding site; other site 592029001884 glycogen synthase; Provisional; Region: glgA; PRK00654 592029001885 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 592029001886 ADP-binding pocket [chemical binding]; other site 592029001887 homodimer interface [polypeptide binding]; other site 592029001888 Yqey-like protein; Region: YqeY; pfam09424 592029001889 cell division protein FtsZ; Validated; Region: PRK09330 592029001890 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 592029001891 nucleotide binding site [chemical binding]; other site 592029001892 SulA interaction site; other site 592029001893 cell division protein FtsA; Region: ftsA; TIGR01174 592029001894 Cell division protein FtsA; Region: FtsA; smart00842 592029001895 Cell division protein FtsA; Region: FtsA; pfam14450 592029001896 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 592029001897 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592029001898 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029001899 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592029001900 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 592029001901 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 592029001902 homodimer interface [polypeptide binding]; other site 592029001903 active site 592029001904 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 592029001905 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 592029001906 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029001907 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592029001908 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 592029001909 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 592029001910 Mg++ binding site [ion binding]; other site 592029001911 putative catalytic motif [active] 592029001912 putative substrate binding site [chemical binding]; other site 592029001913 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 592029001914 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592029001915 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029001916 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592029001917 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 592029001918 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592029001919 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592029001920 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 592029001921 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 592029001922 MraW methylase family; Region: Methyltransf_5; cl17771 592029001923 cell division protein MraZ; Reviewed; Region: PRK00326 592029001924 MraZ protein; Region: MraZ; pfam02381 592029001925 MraZ protein; Region: MraZ; pfam02381 592029001926 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029001927 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 592029001928 G1 box; other site 592029001929 GTP/Mg2+ binding site [chemical binding]; other site 592029001930 Switch I region; other site 592029001931 G2 box; other site 592029001932 G3 box; other site 592029001933 Switch II region; other site 592029001934 G4 box; other site 592029001935 G5 box; other site 592029001936 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 592029001937 gliding motility-associated protein GldC; Region: GldC; TIGR03515 592029001938 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 592029001939 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 592029001940 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 592029001941 homodimer interface [polypeptide binding]; other site 592029001942 NAD binding pocket [chemical binding]; other site 592029001943 ATP binding pocket [chemical binding]; other site 592029001944 Mg binding site [ion binding]; other site 592029001945 active-site loop [active] 592029001946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029001948 active site 592029001949 phosphorylation site [posttranslational modification] 592029001950 intermolecular recognition site; other site 592029001951 dimerization interface [polypeptide binding]; other site 592029001952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029001953 DNA binding residues [nucleotide binding] 592029001954 dimerization interface [polypeptide binding]; other site 592029001955 DNA primase, catalytic core; Region: dnaG; TIGR01391 592029001956 CHC2 zinc finger; Region: zf-CHC2; cl17510 592029001957 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 592029001958 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 592029001959 active site 592029001960 metal binding site [ion binding]; metal-binding site 592029001961 interdomain interaction site; other site 592029001962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029001963 binding surface 592029001964 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029001965 TPR motif; other site 592029001966 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029001967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029001968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029001969 ATP binding site [chemical binding]; other site 592029001970 Mg2+ binding site [ion binding]; other site 592029001971 G-X-G motif; other site 592029001972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029001973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 592029001974 active site 592029001975 phosphorylation site [posttranslational modification] 592029001976 intermolecular recognition site; other site 592029001977 dimerization interface [polypeptide binding]; other site 592029001978 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 592029001979 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 592029001980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 592029001981 ATP binding site [chemical binding]; other site 592029001982 putative Mg++ binding site [ion binding]; other site 592029001983 Protein of unknown function DUF262; Region: DUF262; pfam03235 592029001984 Uncharacterized conserved protein [Function unknown]; Region: COG1479 592029001985 Protein of unknown function DUF262; Region: DUF262; pfam03235 592029001986 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 592029001987 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 592029001988 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592029001989 Virulence protein [General function prediction only]; Region: COG3943 592029001990 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 592029001991 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 592029001992 HsdM N-terminal domain; Region: HsdM_N; pfam12161 592029001993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029001994 S-adenosylmethionine binding site [chemical binding]; other site 592029001995 hypothetical protein; Provisional; Region: yieM; PRK10997 592029001996 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 592029001997 metal ion-dependent adhesion site (MIDAS); other site 592029001998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029001999 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592029002000 Walker A motif; other site 592029002001 ATP binding site [chemical binding]; other site 592029002002 Walker B motif; other site 592029002003 arginine finger; other site 592029002004 EcsC protein family; Region: EcsC; pfam12787 592029002005 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592029002006 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 592029002007 putative active site [active] 592029002008 putative catalytic site [active] 592029002009 putative Mg binding site IVb [ion binding]; other site 592029002010 putative phosphate binding site [ion binding]; other site 592029002011 putative DNA binding site [nucleotide binding]; other site 592029002012 putative Mg binding site IVa [ion binding]; other site 592029002013 Protein of unknown function, DUF488; Region: DUF488; pfam04343 592029002014 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 592029002015 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 592029002016 catalytic residues [active] 592029002017 catalytic nucleophile [active] 592029002018 Presynaptic Site I dimer interface [polypeptide binding]; other site 592029002019 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 592029002020 Synaptic Flat tetramer interface [polypeptide binding]; other site 592029002021 Synaptic Site I dimer interface [polypeptide binding]; other site 592029002022 DNA binding site [nucleotide binding] 592029002023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029002024 AAA domain; Region: AAA_23; pfam13476 592029002025 Walker A/P-loop; other site 592029002026 ATP binding site [chemical binding]; other site 592029002027 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 592029002028 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 592029002029 catalytic residues [active] 592029002030 catalytic nucleophile [active] 592029002031 Recombinase; Region: Recombinase; pfam07508 592029002032 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 592029002033 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 592029002034 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 592029002035 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592029002036 Protein export membrane protein; Region: SecD_SecF; cl14618 592029002037 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592029002038 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029002039 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592029002040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029002041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029002042 ABC transporter; Region: ABC_tran_2; pfam12848 592029002043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029002044 CpXC protein; Region: CpXC; pfam14353 592029002045 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592029002046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592029002047 gliding motility associated protien GldN; Region: GldN; TIGR03523 592029002048 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 592029002049 GldM N-terminal domain; Region: GldM_N; pfam12081 592029002050 GldM C-terminal domain; Region: GldM_C; pfam12080 592029002051 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 592029002052 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 592029002053 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 592029002054 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 592029002055 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 592029002056 putative active site [active] 592029002057 putative metal binding site [ion binding]; other site 592029002058 DNA topoisomerase I; Validated; Region: PRK06599 592029002059 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 592029002060 active site 592029002061 interdomain interaction site; other site 592029002062 putative metal-binding site [ion binding]; other site 592029002063 nucleotide binding site [chemical binding]; other site 592029002064 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592029002065 domain I; other site 592029002066 DNA binding groove [nucleotide binding] 592029002067 phosphate binding site [ion binding]; other site 592029002068 domain II; other site 592029002069 domain III; other site 592029002070 nucleotide binding site [chemical binding]; other site 592029002071 catalytic site [active] 592029002072 domain IV; other site 592029002073 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 592029002074 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 592029002075 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592029002076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592029002077 FeS/SAM binding site; other site 592029002078 TRAM domain; Region: TRAM; pfam01938 592029002079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029002080 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592029002081 Walker A motif; other site 592029002082 ATP binding site [chemical binding]; other site 592029002083 Walker B motif; other site 592029002084 arginine finger; other site 592029002085 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592029002086 Lipopolysaccharide-assembly; Region: LptE; cl01125 592029002087 tetratricopeptide repeat protein; Provisional; Region: PRK11788 592029002088 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 592029002089 oligomerisation interface [polypeptide binding]; other site 592029002090 mobile loop; other site 592029002091 roof hairpin; other site 592029002092 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 592029002093 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 592029002094 ring oligomerisation interface [polypeptide binding]; other site 592029002095 ATP/Mg binding site [chemical binding]; other site 592029002096 stacking interactions; other site 592029002097 hinge regions; other site 592029002098 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 592029002099 active site 592029002100 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 592029002101 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 592029002102 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 592029002103 GAF domain; Region: GAF_2; pfam13185 592029002104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029002105 S-adenosylmethionine binding site [chemical binding]; other site 592029002106 Sulfatase; Region: Sulfatase; cl17466 592029002107 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002108 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 592029002109 Phage Tail Collar Domain; Region: Collar; pfam07484 592029002110 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 592029002111 Phage Tail Collar Domain; Region: Collar; pfam07484 592029002112 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002113 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 592029002114 Phage Tail Collar Domain; Region: Collar; pfam07484 592029002115 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 592029002116 Phage Tail Collar Domain; Region: Collar; pfam07484 592029002117 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 592029002118 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 592029002119 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 592029002120 RimM N-terminal domain; Region: RimM; pfam01782 592029002121 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 592029002122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029002123 S-adenosylmethionine binding site [chemical binding]; other site 592029002124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592029002125 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592029002126 active site 592029002127 NifU-like domain; Region: NifU; cl00484 592029002128 Domain of unknown function DUF59; Region: DUF59; cl00941 592029002129 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 592029002130 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 592029002131 Walker A motif; other site 592029002132 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 592029002133 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592029002134 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 592029002135 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029002136 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029002137 catalytic residues [active] 592029002138 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 592029002139 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cd12213 592029002140 ligand binding site [chemical binding]; other site 592029002141 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 592029002142 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 592029002143 GIY-YIG motif/motif A; other site 592029002144 active site 592029002145 catalytic site [active] 592029002146 putative DNA binding site [nucleotide binding]; other site 592029002147 metal binding site [ion binding]; metal-binding site 592029002148 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 592029002149 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 592029002150 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 592029002151 active site 592029002152 nucleophile elbow; other site 592029002153 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 592029002154 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029002155 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 592029002156 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 592029002157 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 592029002158 dimer interface [polypeptide binding]; other site 592029002159 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 592029002160 active site 592029002161 Fe binding site [ion binding]; other site 592029002162 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 592029002163 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 592029002164 putative peptidase; Provisional; Region: PRK11649 592029002165 Peptidase family M23; Region: Peptidase_M23; pfam01551 592029002166 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 592029002167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 592029002168 active site 592029002169 dimer interface [polypeptide binding]; other site 592029002170 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 592029002171 dimer interface [polypeptide binding]; other site 592029002172 active site 592029002173 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 592029002174 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029002175 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592029002176 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 592029002177 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002178 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 592029002179 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 592029002180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029002181 ATP binding site [chemical binding]; other site 592029002182 putative Mg++ binding site [ion binding]; other site 592029002183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029002184 nucleotide binding region [chemical binding]; other site 592029002185 ATP-binding site [chemical binding]; other site 592029002186 TRCF domain; Region: TRCF; pfam03461 592029002187 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 592029002188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029002189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029002190 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592029002191 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592029002192 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 592029002193 putative active site [active] 592029002194 putative metal binding site [ion binding]; other site 592029002195 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029002196 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 592029002197 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592029002198 N-terminal plug; other site 592029002199 ligand-binding site [chemical binding]; other site 592029002200 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 592029002201 Recombination protein O N terminal; Region: RecO_N; pfam11967 592029002202 Recombination protein O C terminal; Region: RecO_C; pfam02565 592029002203 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 592029002204 glutamate dehydrogenase; Provisional; Region: PRK09414 592029002205 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592029002206 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 592029002207 NAD(P) binding site [chemical binding]; other site 592029002208 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592029002209 active site residue [active] 592029002210 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 592029002211 active site 592029002212 putative DNA-binding cleft [nucleotide binding]; other site 592029002213 dimer interface [polypeptide binding]; other site 592029002214 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592029002215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029002216 active site 592029002217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002218 binding surface 592029002219 TPR motif; other site 592029002220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002221 TPR motif; other site 592029002222 binding surface 592029002223 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 592029002224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592029002225 binding surface 592029002226 TPR motif; other site 592029002227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029002228 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592029002229 active site 592029002230 motif I; other site 592029002231 motif II; other site 592029002232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029002233 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 592029002234 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592029002235 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 592029002236 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 592029002237 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029002238 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029002239 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 592029002240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029002241 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 592029002242 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029002243 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029002244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029002245 Histidine kinase; Region: His_kinase; pfam06580 592029002246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029002247 ATP binding site [chemical binding]; other site 592029002248 Mg2+ binding site [ion binding]; other site 592029002249 G-X-G motif; other site 592029002250 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 592029002251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029002252 active site 592029002253 phosphorylation site [posttranslational modification] 592029002254 intermolecular recognition site; other site 592029002255 dimerization interface [polypeptide binding]; other site 592029002256 LytTr DNA-binding domain; Region: LytTR; smart00850 592029002257 Predicted transcriptional regulators [Transcription]; Region: COG1733 592029002258 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592029002259 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 592029002260 NmrA-like family; Region: NmrA; pfam05368 592029002261 NADP binding site [chemical binding]; other site 592029002262 active site 592029002263 regulatory binding site [polypeptide binding]; other site 592029002264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592029002265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592029002266 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 592029002267 Walker A/P-loop; other site 592029002268 ATP binding site [chemical binding]; other site 592029002269 Q-loop/lid; other site 592029002270 ABC transporter signature motif; other site 592029002271 Walker B; other site 592029002272 D-loop; other site 592029002273 H-loop/switch region; other site 592029002274 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592029002275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002276 TPR repeat; Region: TPR_11; pfam13414 592029002277 binding surface 592029002278 TPR motif; other site 592029002279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029002280 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 592029002281 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 592029002282 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 592029002283 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 592029002284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592029002285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029002286 Predicted integral membrane protein [Function unknown]; Region: COG5616 592029002287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002288 TPR motif; other site 592029002289 binding surface 592029002290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002291 binding surface 592029002292 TPR motif; other site 592029002293 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 592029002294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002295 TPR motif; other site 592029002296 TPR repeat; Region: TPR_11; pfam13414 592029002297 binding surface 592029002298 hypothetical protein; Provisional; Region: PRK08201 592029002299 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 592029002300 metal binding site [ion binding]; metal-binding site 592029002301 putative dimer interface [polypeptide binding]; other site 592029002302 Penicillinase repressor; Region: Pencillinase_R; pfam03965 592029002303 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 592029002304 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 592029002305 Uncharacterized conserved protein [Function unknown]; Region: COG4850 592029002306 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 592029002307 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 592029002308 active site 592029002309 metal binding site [ion binding]; metal-binding site 592029002310 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 592029002311 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 592029002312 Na binding site [ion binding]; other site 592029002313 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 592029002314 starch binding outer membrane protein SusD; Region: SusD; cd08977 592029002315 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029002316 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029002317 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592029002318 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029002319 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 592029002320 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 592029002321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592029002322 FeS/SAM binding site; other site 592029002323 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 592029002324 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 592029002325 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 592029002326 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 592029002327 active site 592029002328 catalytic site [active] 592029002329 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 592029002330 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 592029002331 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 592029002332 active site 592029002333 catalytic site [active] 592029002334 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 592029002335 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 592029002336 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 592029002337 Ca binding site [ion binding]; other site 592029002338 active site 592029002339 homodimer interface [polypeptide binding]; other site 592029002340 catalytic site [active] 592029002341 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 592029002342 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 592029002343 maltose phosphorylase; Provisional; Region: PRK13807 592029002344 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 592029002345 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 592029002346 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 592029002347 beta-phosphoglucomutase; Region: bPGM; TIGR01990 592029002348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029002349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592029002350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029002351 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592029002352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592029002353 DNA binding site [nucleotide binding] 592029002354 domain linker motif; other site 592029002355 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592029002356 ligand binding site [chemical binding]; other site 592029002357 dimerization interface [polypeptide binding]; other site 592029002358 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029002359 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029002360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029002361 starch binding outer membrane protein SusD; Region: SusD; cd08977 592029002362 SusE outer membrane protein; Region: SusE; pfam14292 592029002363 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 592029002364 starch binding site [chemical binding]; other site 592029002365 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 592029002366 starch binding site [chemical binding]; other site 592029002367 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 592029002368 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 592029002369 active site 592029002370 catalytic site [active] 592029002371 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002372 Protein of unknown function DUF58; Region: DUF58; pfam01882 592029002373 von Willebrand factor type A domain; Region: VWA_2; pfam13519 592029002374 metal ion-dependent adhesion site (MIDAS); other site 592029002375 Prostaglandin dehydrogenases; Region: PGDH; cd05288 592029002376 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 592029002377 NAD(P) binding site [chemical binding]; other site 592029002378 substrate binding site [chemical binding]; other site 592029002379 dimer interface [polypeptide binding]; other site 592029002380 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029002381 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029002382 catalytic residues [active] 592029002383 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 592029002384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029002385 S-adenosylmethionine binding site [chemical binding]; other site 592029002386 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 592029002387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002388 TPR motif; other site 592029002389 binding surface 592029002390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592029002391 binding surface 592029002392 TPR motif; other site 592029002393 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 592029002394 seryl-tRNA synthetase; Provisional; Region: PRK05431 592029002395 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 592029002396 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 592029002397 dimer interface [polypeptide binding]; other site 592029002398 active site 592029002399 motif 1; other site 592029002400 motif 2; other site 592029002401 motif 3; other site 592029002402 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 592029002403 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 592029002404 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 592029002405 active site 592029002406 Riboflavin kinase; Region: Flavokinase; pfam01687 592029002407 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 592029002408 putative active site [active] 592029002409 catalytic residue [active] 592029002410 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 592029002411 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 592029002412 5S rRNA interface [nucleotide binding]; other site 592029002413 CTC domain interface [polypeptide binding]; other site 592029002414 L16 interface [polypeptide binding]; other site 592029002415 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 592029002416 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 592029002417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029002418 active site 592029002419 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 592029002420 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 592029002421 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 592029002422 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029002423 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 592029002424 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 592029002425 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 592029002426 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 592029002427 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 592029002428 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 592029002429 putative dimer interface [polypeptide binding]; other site 592029002430 putative anticodon binding site; other site 592029002431 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 592029002432 homodimer interface [polypeptide binding]; other site 592029002433 motif 1; other site 592029002434 motif 2; other site 592029002435 active site 592029002436 motif 3; other site 592029002437 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 592029002438 ribosome recycling factor; Reviewed; Region: frr; PRK00083 592029002439 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 592029002440 hinge region; other site 592029002441 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 592029002442 putative nucleotide binding site [chemical binding]; other site 592029002443 uridine monophosphate binding site [chemical binding]; other site 592029002444 homohexameric interface [polypeptide binding]; other site 592029002445 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 592029002446 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 592029002447 dimer interface [polypeptide binding]; other site 592029002448 putative radical transfer pathway; other site 592029002449 diiron center [ion binding]; other site 592029002450 tyrosyl radical; other site 592029002451 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 592029002452 ATP cone domain; Region: ATP-cone; pfam03477 592029002453 Class I ribonucleotide reductase; Region: RNR_I; cd01679 592029002454 active site 592029002455 dimer interface [polypeptide binding]; other site 592029002456 catalytic residues [active] 592029002457 effector binding site; other site 592029002458 R2 peptide binding site; other site 592029002459 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 592029002460 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 592029002461 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 592029002462 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 592029002463 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 592029002464 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002465 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002466 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002467 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002468 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002469 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002470 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 592029002471 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002472 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029002473 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592029002474 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 592029002475 alpha subunit interface [polypeptide binding]; other site 592029002476 TPP binding site [chemical binding]; other site 592029002477 heterodimer interface [polypeptide binding]; other site 592029002478 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592029002479 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 592029002480 Electron transfer flavoprotein domain; Region: ETF; pfam01012 592029002481 Ligand binding site [chemical binding]; other site 592029002482 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 592029002483 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 592029002484 Ligand Binding Site [chemical binding]; other site 592029002485 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 592029002486 Bifunctional nuclease; Region: DNase-RNase; pfam02577 592029002487 UvrB/uvrC motif; Region: UVR; pfam02151 592029002488 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 592029002489 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592029002490 Nucleoside recognition; Region: Gate; pfam07670 592029002491 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592029002492 thymidylate synthase; Reviewed; Region: thyA; PRK01827 592029002493 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 592029002494 dimerization interface [polypeptide binding]; other site 592029002495 active site 592029002496 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 592029002497 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 592029002498 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 592029002499 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 592029002500 Domain of unknown function (DUF427); Region: DUF427; pfam04248 592029002501 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 592029002502 23S rRNA interface [nucleotide binding]; other site 592029002503 L3 interface [polypeptide binding]; other site 592029002504 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 592029002505 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 592029002506 rRNA interaction site [nucleotide binding]; other site 592029002507 S8 interaction site; other site 592029002508 putative laminin-1 binding site; other site 592029002509 elongation factor Ts; Provisional; Region: tsf; PRK09377 592029002510 UBA/TS-N domain; Region: UBA; pfam00627 592029002511 Elongation factor TS; Region: EF_TS; pfam00889 592029002512 Elongation factor TS; Region: EF_TS; pfam00889 592029002513 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592029002514 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 592029002515 active site 592029002516 DNA binding site [nucleotide binding] 592029002517 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592029002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029002519 S-adenosylmethionine binding site [chemical binding]; other site 592029002520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029002521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029002522 dimer interface [polypeptide binding]; other site 592029002523 phosphorylation site [posttranslational modification] 592029002524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029002525 ATP binding site [chemical binding]; other site 592029002526 Mg2+ binding site [ion binding]; other site 592029002527 G-X-G motif; other site 592029002528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592029002529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029002530 active site 592029002531 phosphorylation site [posttranslational modification] 592029002532 intermolecular recognition site; other site 592029002533 dimerization interface [polypeptide binding]; other site 592029002534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592029002535 DNA binding site [nucleotide binding] 592029002536 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002537 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 592029002538 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 592029002539 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 592029002540 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 592029002541 active site 592029002542 HIGH motif; other site 592029002543 dimer interface [polypeptide binding]; other site 592029002544 KMSKS motif; other site 592029002545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029002546 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 592029002547 NAD(P) binding site [chemical binding]; other site 592029002548 active site 592029002549 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 592029002550 dihydroorotase; Reviewed; Region: PRK09236 592029002551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592029002552 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 592029002553 active site 592029002554 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 592029002555 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 592029002556 Ligand binding site; other site 592029002557 Putative Catalytic site; other site 592029002558 DXD motif; other site 592029002559 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 592029002560 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 592029002561 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 592029002562 active site 592029002563 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 592029002564 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 592029002565 active site 592029002566 substrate-binding site [chemical binding]; other site 592029002567 metal-binding site [ion binding] 592029002568 ATP binding site [chemical binding]; other site 592029002569 Protein of unknown function (DUF423); Region: DUF423; pfam04241 592029002570 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 592029002571 TrkA-N domain; Region: TrkA_N; pfam02254 592029002572 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 592029002573 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 592029002574 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 592029002575 heme-binding site [chemical binding]; other site 592029002576 Gram-negative bacterial tonB protein; Region: TonB; cl10048 592029002577 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 592029002578 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 592029002579 lipoyl attachment site [posttranslational modification]; other site 592029002580 cell surface protein SprA; Region: surface_SprA; TIGR04189 592029002581 Motility related/secretion protein; Region: SprA_N; pfam14349 592029002582 Motility related/secretion protein; Region: SprA_N; pfam14349 592029002583 Motility related/secretion protein; Region: SprA_N; pfam14349 592029002584 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 592029002585 RuvA N terminal domain; Region: RuvA_N; pfam01330 592029002586 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 592029002587 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 592029002588 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592029002589 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 592029002590 putative NAD(P) binding site [chemical binding]; other site 592029002591 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 592029002592 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592029002594 Cytochrome P450; Region: p450; cl12078 592029002595 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 592029002596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029002597 Walker A motif; other site 592029002598 ATP binding site [chemical binding]; other site 592029002599 Walker B motif; other site 592029002600 arginine finger; other site 592029002601 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 592029002602 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 592029002603 putative catalytic residues [active] 592029002604 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 592029002605 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 592029002606 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 592029002607 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 592029002608 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592029002609 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592029002610 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 592029002611 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 592029002612 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 592029002613 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 592029002614 molybdopterin cofactor binding site; other site 592029002615 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 592029002616 4Fe-4S binding domain; Region: Fer4; cl02805 592029002617 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 592029002618 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592029002619 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592029002620 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 592029002621 heme-binding residues [chemical binding]; other site 592029002622 Sporulation related domain; Region: SPOR; cl10051 592029002623 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 592029002624 putative catalytic site [active] 592029002625 putative metal binding site [ion binding]; other site 592029002626 putative phosphate binding site [ion binding]; other site 592029002627 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029002628 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029002629 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029002630 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029002631 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029002632 ligand binding site [chemical binding]; other site 592029002633 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592029002634 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 592029002635 substrate-cofactor binding pocket; other site 592029002636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029002637 catalytic residue [active] 592029002638 putative recombination protein RecB; Provisional; Region: PRK13909 592029002639 Family description; Region: UvrD_C_2; pfam13538 592029002640 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 592029002641 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 592029002642 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 592029002643 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 592029002644 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002645 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 592029002646 active site 592029002647 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 592029002648 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592029002649 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 592029002650 substrate binding site [chemical binding]; other site 592029002651 ATP binding site [chemical binding]; other site 592029002652 GH3 auxin-responsive promoter; Region: GH3; pfam03321 592029002653 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 592029002654 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029002655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002656 TPR motif; other site 592029002657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029002658 binding surface 592029002659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029002660 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 592029002661 ATP binding site [chemical binding]; other site 592029002662 Mg2+ binding site [ion binding]; other site 592029002663 G-X-G motif; other site 592029002664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 592029002665 Histidine kinase; Region: HisKA_2; pfam07568 592029002666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029002667 ATP binding site [chemical binding]; other site 592029002668 Mg2+ binding site [ion binding]; other site 592029002669 G-X-G motif; other site 592029002670 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592029002671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029002672 active site 592029002673 phosphorylation site [posttranslational modification] 592029002674 intermolecular recognition site; other site 592029002675 dimerization interface [polypeptide binding]; other site 592029002676 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 592029002677 amidase catalytic site [active] 592029002678 Zn binding residues [ion binding]; other site 592029002679 substrate binding site [chemical binding]; other site 592029002680 CARDB; Region: CARDB; pfam07705 592029002681 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002682 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 592029002683 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029002684 active site 592029002685 HIGH motif; other site 592029002686 nucleotide binding site [chemical binding]; other site 592029002687 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029002688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029002689 active site 592029002690 KMSKS motif; other site 592029002691 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 592029002692 tRNA binding surface [nucleotide binding]; other site 592029002693 anticodon binding site; other site 592029002694 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 592029002695 lipoprotein signal peptidase; Provisional; Region: PRK14788 592029002696 lipoprotein signal peptidase; Provisional; Region: PRK14787 592029002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029002698 Response regulator receiver domain; Region: Response_reg; pfam00072 592029002699 active site 592029002700 phosphorylation site [posttranslational modification] 592029002701 intermolecular recognition site; other site 592029002702 dimerization interface [polypeptide binding]; other site 592029002703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029002704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029002705 ATP binding site [chemical binding]; other site 592029002706 G-X-G motif; other site 592029002707 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 592029002708 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 592029002709 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 592029002710 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 592029002711 putative active site [active] 592029002712 Zn binding site [ion binding]; other site 592029002713 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 592029002714 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592029002715 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 592029002716 TIGR02594 family protein; Region: TIGR02594 592029002717 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592029002718 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 592029002719 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592029002720 homodimer interface [polypeptide binding]; other site 592029002721 substrate-cofactor binding pocket; other site 592029002722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029002723 catalytic residue [active] 592029002724 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 592029002725 SPFH domain / Band 7 family; Region: Band_7; pfam01145 592029002726 ArsC family; Region: ArsC; pfam03960 592029002727 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592029002728 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592029002729 EamA-like transporter family; Region: EamA; pfam00892 592029002730 EamA-like transporter family; Region: EamA; pfam00892 592029002731 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592029002732 active site 592029002733 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 592029002734 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 592029002735 Ferrochelatase; Region: Ferrochelatase; pfam00762 592029002736 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 592029002737 C-terminal domain interface [polypeptide binding]; other site 592029002738 active site 592029002739 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 592029002740 active site 592029002741 N-terminal domain interface [polypeptide binding]; other site 592029002742 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 592029002743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029002744 NAD(P) binding site [chemical binding]; other site 592029002745 active site 592029002746 MoxR-like ATPases [General function prediction only]; Region: COG0714 592029002747 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 592029002748 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 592029002749 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 592029002750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 592029002751 metal ion-dependent adhesion site (MIDAS); other site 592029002752 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 592029002753 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 592029002754 metal ion-dependent adhesion site (MIDAS); other site 592029002755 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 592029002756 metal ion-dependent adhesion site (MIDAS); other site 592029002757 TPR repeat; Region: TPR_11; pfam13414 592029002758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002759 binding surface 592029002760 TPR motif; other site 592029002761 TPR repeat; Region: TPR_11; pfam13414 592029002762 Oxygen tolerance; Region: BatD; pfam13584 592029002763 Oxygen tolerance; Region: BatD; pfam13584 592029002764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029002765 TPR motif; other site 592029002766 TPR repeat; Region: TPR_11; pfam13414 592029002767 binding surface 592029002768 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 592029002769 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 592029002770 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 592029002771 aldehyde dehydrogenase family 7 member; Region: PLN02315 592029002772 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 592029002773 tetrameric interface [polypeptide binding]; other site 592029002774 NAD binding site [chemical binding]; other site 592029002775 catalytic residues [active] 592029002776 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002777 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 592029002778 catalytic center binding site [active] 592029002779 ATP binding site [chemical binding]; other site 592029002780 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 592029002781 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 592029002782 Substrate-binding site [chemical binding]; other site 592029002783 Substrate specificity [chemical binding]; other site 592029002784 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 592029002785 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 592029002786 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 592029002787 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 592029002788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592029002789 FeS/SAM binding site; other site 592029002790 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 592029002791 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 592029002792 active site 592029002793 PHP Thumb interface [polypeptide binding]; other site 592029002794 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 592029002795 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 592029002796 generic binding surface II; other site 592029002797 generic binding surface I; other site 592029002798 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 592029002799 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 592029002800 active site 592029002801 DNA binding site [nucleotide binding] 592029002802 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 592029002803 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 592029002804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029002805 non-specific DNA binding site [nucleotide binding]; other site 592029002806 salt bridge; other site 592029002807 sequence-specific DNA binding site [nucleotide binding]; other site 592029002808 Predicted transcriptional regulator [Transcription]; Region: COG2932 592029002809 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592029002810 Catalytic site [active] 592029002811 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 592029002812 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029002813 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 592029002814 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 592029002815 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 592029002816 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592029002817 inhibitor-cofactor binding pocket; inhibition site 592029002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029002819 catalytic residue [active] 592029002820 Bacterial SH3 domain; Region: SH3_3; cl17532 592029002821 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 592029002822 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 592029002823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592029002824 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 592029002825 active site 592029002826 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 592029002827 putative active site [active] 592029002828 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002829 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 592029002830 ABC1 family; Region: ABC1; cl17513 592029002831 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 592029002832 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029002833 Methyltransferase domain; Region: Methyltransf_12; pfam08242 592029002834 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 592029002835 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 592029002836 trimer interface [polypeptide binding]; other site 592029002837 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 592029002838 trimer interface [polypeptide binding]; other site 592029002839 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 592029002841 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 592029002842 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 592029002843 dimer interface [polypeptide binding]; other site 592029002844 anticodon binding site; other site 592029002845 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 592029002846 homodimer interface [polypeptide binding]; other site 592029002847 motif 1; other site 592029002848 active site 592029002849 motif 2; other site 592029002850 GAD domain; Region: GAD; pfam02938 592029002851 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592029002852 active site 592029002853 motif 3; other site 592029002854 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 592029002855 dimer interface [polypeptide binding]; other site 592029002856 allosteric magnesium binding site [ion binding]; other site 592029002857 active site 592029002858 aspartate-rich active site metal binding site; other site 592029002859 Schiff base residues; other site 592029002860 RecX family; Region: RecX; pfam02631 592029002861 Cupin-like domain; Region: Cupin_8; pfam13621 592029002862 biotin synthase; Region: bioB; TIGR00433 592029002863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592029002864 FeS/SAM binding site; other site 592029002865 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 592029002866 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 592029002867 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 592029002868 active site 592029002869 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029002870 Interdomain contacts; other site 592029002871 Cytokine receptor motif; other site 592029002872 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002873 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592029002874 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 592029002875 inhibitor-cofactor binding pocket; inhibition site 592029002876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029002877 catalytic residue [active] 592029002878 AAA domain; Region: AAA_26; pfam13500 592029002879 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 592029002880 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 592029002881 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592029002882 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 592029002883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029002884 catalytic residue [active] 592029002885 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 592029002886 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 592029002887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029002888 non-specific DNA binding site [nucleotide binding]; other site 592029002889 salt bridge; other site 592029002890 sequence-specific DNA binding site [nucleotide binding]; other site 592029002891 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 592029002892 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 592029002893 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 592029002894 gamma subunit interface [polypeptide binding]; other site 592029002895 LBP interface [polypeptide binding]; other site 592029002896 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 592029002897 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 592029002898 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 592029002899 alpha subunit interaction interface [polypeptide binding]; other site 592029002900 Walker A motif; other site 592029002901 ATP binding site [chemical binding]; other site 592029002902 Walker B motif; other site 592029002903 inhibitor binding site; inhibition site 592029002904 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592029002905 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 592029002906 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 592029002907 glutaminase active site [active] 592029002908 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 592029002909 dimer interface [polypeptide binding]; other site 592029002910 active site 592029002911 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 592029002912 dimer interface [polypeptide binding]; other site 592029002913 active site 592029002914 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 592029002915 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 592029002916 pantoate--beta-alanine ligase; Region: panC; TIGR00018 592029002917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029002918 active site 592029002919 nucleotide binding site [chemical binding]; other site 592029002920 HIGH motif; other site 592029002921 KMSKS motif; other site 592029002922 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 592029002923 tetramerization interface [polypeptide binding]; other site 592029002924 active site 592029002925 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 592029002926 Putative esterase; Region: Esterase; pfam00756 592029002927 DNA repair protein RadA; Provisional; Region: PRK11823 592029002928 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 592029002929 Walker A motif/ATP binding site; other site 592029002930 ATP binding site [chemical binding]; other site 592029002931 Walker B motif; other site 592029002932 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 592029002933 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029002934 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029002935 catalytic residues [active] 592029002936 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 592029002937 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592029002938 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592029002939 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592029002940 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 592029002941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592029002942 carboxyltransferase (CT) interaction site; other site 592029002943 biotinylation site [posttranslational modification]; other site 592029002944 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 592029002945 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592029002946 dimer interface [polypeptide binding]; other site 592029002947 active site 592029002948 CoA binding pocket [chemical binding]; other site 592029002949 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 592029002950 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 592029002951 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 592029002952 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 592029002953 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 592029002954 Lumazine binding domain; Region: Lum_binding; pfam00677 592029002955 Lumazine binding domain; Region: Lum_binding; pfam00677 592029002956 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 592029002957 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 592029002958 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 592029002959 active site 592029002960 catalytic residues [active] 592029002961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592029002962 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 592029002963 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 592029002964 TrkA-N domain; Region: TrkA_N; pfam02254 592029002965 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 592029002966 putative efflux protein, MATE family; Region: matE; TIGR00797 592029002967 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 592029002968 active site 592029002969 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029002970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029002971 catalytic residues [active] 592029002972 Predicted acyl esterases [General function prediction only]; Region: COG2936 592029002973 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 592029002974 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 592029002975 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 592029002976 active site 592029002977 Zn binding site [ion binding]; other site 592029002978 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029002979 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 592029002980 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029002981 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 592029002982 SnoaL-like domain; Region: SnoaL_3; pfam13474 592029002983 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 592029002984 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 592029002985 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 592029002986 PSP1 C-terminal conserved region; Region: PSP1; cl00770 592029002987 GldH lipoprotein; Region: GldH_lipo; pfam14109 592029002988 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 592029002989 Transglycosylase; Region: Transgly; pfam00912 592029002990 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 592029002991 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 592029002992 active site 592029002993 catalytic site [active] 592029002994 substrate binding site [chemical binding]; other site 592029002995 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592029002996 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592029002997 Walker A/P-loop; other site 592029002998 ATP binding site [chemical binding]; other site 592029002999 Q-loop/lid; other site 592029003000 ABC transporter signature motif; other site 592029003001 Walker B; other site 592029003002 D-loop; other site 592029003003 H-loop/switch region; other site 592029003004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592029003005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592029003006 Walker A/P-loop; other site 592029003007 ATP binding site [chemical binding]; other site 592029003008 Q-loop/lid; other site 592029003009 ABC transporter signature motif; other site 592029003010 Walker B; other site 592029003011 D-loop; other site 592029003012 H-loop/switch region; other site 592029003013 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592029003014 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 592029003015 MutS domain I; Region: MutS_I; pfam01624 592029003016 MutS domain II; Region: MutS_II; pfam05188 592029003017 MutS domain III; Region: MutS_III; pfam05192 592029003018 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 592029003019 Walker A/P-loop; other site 592029003020 ATP binding site [chemical binding]; other site 592029003021 Q-loop/lid; other site 592029003022 ABC transporter signature motif; other site 592029003023 Walker B; other site 592029003024 D-loop; other site 592029003025 H-loop/switch region; other site 592029003026 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 592029003027 metal ion-dependent adhesion site (MIDAS); other site 592029003028 Protein of unknown function (DUF541); Region: SIMPL; cl01077 592029003029 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029003030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029003031 binding surface 592029003032 TPR motif; other site 592029003033 Histidine kinase; Region: His_kinase; pfam06580 592029003034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029003035 ATP binding site [chemical binding]; other site 592029003036 Mg2+ binding site [ion binding]; other site 592029003037 G-X-G motif; other site 592029003038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029003039 Response regulator receiver domain; Region: Response_reg; pfam00072 592029003040 active site 592029003041 phosphorylation site [posttranslational modification] 592029003042 intermolecular recognition site; other site 592029003043 dimerization interface [polypeptide binding]; other site 592029003044 LytTr DNA-binding domain; Region: LytTR; smart00850 592029003045 glutamate racemase; Provisional; Region: PRK00865 592029003046 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 592029003047 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 592029003048 G1 box; other site 592029003049 GTP/Mg2+ binding site [chemical binding]; other site 592029003050 Switch I region; other site 592029003051 G2 box; other site 592029003052 G3 box; other site 592029003053 Switch II region; other site 592029003054 G4 box; other site 592029003055 G5 box; other site 592029003056 Nucleoside recognition; Region: Gate; pfam07670 592029003057 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 592029003058 Nucleoside recognition; Region: Gate; pfam07670 592029003059 FeoA domain; Region: FeoA; pfam04023 592029003060 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 592029003061 RNA/DNA hybrid binding site [nucleotide binding]; other site 592029003062 active site 592029003063 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 592029003064 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 592029003065 active site 592029003066 substrate binding site [chemical binding]; other site 592029003067 cosubstrate binding site; other site 592029003068 catalytic site [active] 592029003069 acyl carrier protein; Provisional; Region: acpP; PRK00982 592029003070 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 592029003071 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592029003072 dimer interface [polypeptide binding]; other site 592029003073 active site 592029003074 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 592029003075 dimerization interface [polypeptide binding]; other site 592029003076 active site 592029003077 metal binding site [ion binding]; metal-binding site 592029003078 Double-stranded RNA binding motif; Region: dsrm; pfam00035 592029003079 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 592029003080 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 592029003081 domain interfaces; other site 592029003082 active site 592029003083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592029003084 PAS domain; Region: PAS_9; pfam13426 592029003085 putative active site [active] 592029003086 heme pocket [chemical binding]; other site 592029003087 DNA polymerase IV; Validated; Region: PRK02406 592029003088 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 592029003089 active site 592029003090 DNA binding site [nucleotide binding] 592029003091 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 592029003092 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 592029003093 NAD binding site [chemical binding]; other site 592029003094 active site 592029003095 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 592029003096 putative active site [active] 592029003097 putative metal binding residues [ion binding]; other site 592029003098 signature motif; other site 592029003099 putative dimer interface [polypeptide binding]; other site 592029003100 putative phosphate binding site [ion binding]; other site 592029003101 YCII-related domain; Region: YCII; cl00999 592029003102 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029003103 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029003104 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 592029003105 Transglycosylase; Region: Transgly; pfam00912 592029003106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 592029003107 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 592029003108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029003109 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592029003110 NAD(P) binding site [chemical binding]; other site 592029003111 active site 592029003112 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 592029003113 Peptidase family M28; Region: Peptidase_M28; pfam04389 592029003114 metal binding site [ion binding]; metal-binding site 592029003115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029003116 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 592029003117 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 592029003118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592029003119 Coenzyme A binding pocket [chemical binding]; other site 592029003120 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 592029003121 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592029003122 active site 592029003123 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 592029003124 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592029003125 putative substrate binding region [chemical binding]; other site 592029003126 Peptidase family M1; Region: Peptidase_M1; pfam01433 592029003127 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 592029003128 Zn binding site [ion binding]; other site 592029003129 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003130 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 592029003131 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 592029003132 Cu(I) binding site [ion binding]; other site 592029003133 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 592029003134 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029003135 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029003136 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029003137 GTP-binding protein LepA; Provisional; Region: PRK05433 592029003138 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 592029003139 G1 box; other site 592029003140 putative GEF interaction site [polypeptide binding]; other site 592029003141 GTP/Mg2+ binding site [chemical binding]; other site 592029003142 Switch I region; other site 592029003143 G2 box; other site 592029003144 G3 box; other site 592029003145 Switch II region; other site 592029003146 G4 box; other site 592029003147 G5 box; other site 592029003148 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 592029003149 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 592029003150 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 592029003151 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029003152 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 592029003153 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029003154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029003155 TPR motif; other site 592029003156 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029003157 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029003158 ligand binding site [chemical binding]; other site 592029003159 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 592029003160 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 592029003161 putative catalytic site [active] 592029003162 putative metal binding site [ion binding]; other site 592029003163 putative phosphate binding site [ion binding]; other site 592029003164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029003165 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 592029003166 Acyl transferase domain; Region: Acyl_transf_1; cl08282 592029003167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592029003168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592029003169 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 592029003170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029003171 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029003172 thiamine-monophosphate kinase; Region: thiL; TIGR01379 592029003173 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 592029003174 ATP binding site [chemical binding]; other site 592029003175 dimerization interface [polypeptide binding]; other site 592029003176 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 592029003177 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 592029003178 putative ABC transporter; Region: ycf24; CHL00085 592029003179 FeS assembly ATPase SufC; Region: sufC; TIGR01978 592029003180 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 592029003181 Walker A/P-loop; other site 592029003182 ATP binding site [chemical binding]; other site 592029003183 Q-loop/lid; other site 592029003184 ABC transporter signature motif; other site 592029003185 Walker B; other site 592029003186 D-loop; other site 592029003187 H-loop/switch region; other site 592029003188 FeS assembly protein SufD; Region: sufD; TIGR01981 592029003189 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 592029003190 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 592029003191 O-Antigen ligase; Region: Wzy_C; pfam04932 592029003192 TPR repeat; Region: TPR_11; pfam13414 592029003193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029003194 binding surface 592029003195 TPR motif; other site 592029003196 TPR repeat; Region: TPR_11; pfam13414 592029003197 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 592029003198 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 592029003199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029003200 catalytic residue [active] 592029003201 META domain; Region: META; pfam03724 592029003202 Fe-S metabolism associated domain; Region: SufE; cl00951 592029003203 Domain of unknown function DUF59; Region: DUF59; cl00941 592029003204 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 592029003205 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 592029003206 putative metal binding site [ion binding]; other site 592029003207 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592029003208 HSP70 interaction site [polypeptide binding]; other site 592029003209 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 592029003210 active site 592029003211 NTP binding site [chemical binding]; other site 592029003212 metal binding triad [ion binding]; metal-binding site 592029003213 antibiotic binding site [chemical binding]; other site 592029003214 Protein of unknown function DUF86; Region: DUF86; cl01031 592029003215 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 592029003216 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 592029003217 RNA binding site [nucleotide binding]; other site 592029003218 active site 592029003219 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 592029003220 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592029003221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029003222 Walker A/P-loop; other site 592029003223 ATP binding site [chemical binding]; other site 592029003224 Q-loop/lid; other site 592029003225 ABC transporter signature motif; other site 592029003226 Walker B; other site 592029003227 D-loop; other site 592029003228 H-loop/switch region; other site 592029003229 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 592029003230 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029003231 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 592029003232 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003233 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 592029003234 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592029003235 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 592029003236 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 592029003237 alanine racemase; Reviewed; Region: alr; PRK00053 592029003238 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 592029003239 active site 592029003240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592029003241 dimer interface [polypeptide binding]; other site 592029003242 substrate binding site [chemical binding]; other site 592029003243 catalytic residues [active] 592029003244 thymidine kinase; Provisional; Region: PRK04296 592029003245 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 592029003246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029003247 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029003248 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 592029003249 nucleophilic elbow; other site 592029003250 catalytic triad; other site 592029003251 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003252 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 592029003253 core domain interface [polypeptide binding]; other site 592029003254 delta subunit interface [polypeptide binding]; other site 592029003255 epsilon subunit interface [polypeptide binding]; other site 592029003256 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 592029003257 four helix bundle protein; Region: TIGR02436 592029003258 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 592029003259 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 592029003260 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 592029003261 beta subunit interaction interface [polypeptide binding]; other site 592029003262 Walker A motif; other site 592029003263 ATP binding site [chemical binding]; other site 592029003264 Walker B motif; other site 592029003265 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592029003266 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 592029003267 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 592029003268 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 592029003269 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 592029003270 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 592029003271 ATP synthase A chain; Region: ATP-synt_A; cl00413 592029003272 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 592029003273 TraB family; Region: TraB; pfam01963 592029003274 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 592029003275 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592029003276 Walker A/P-loop; other site 592029003277 ATP binding site [chemical binding]; other site 592029003278 Q-loop/lid; other site 592029003279 ABC transporter signature motif; other site 592029003280 Walker B; other site 592029003281 D-loop; other site 592029003282 H-loop/switch region; other site 592029003283 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 592029003284 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 592029003285 FAD binding pocket [chemical binding]; other site 592029003286 FAD binding motif [chemical binding]; other site 592029003287 phosphate binding motif [ion binding]; other site 592029003288 beta-alpha-beta structure motif; other site 592029003289 NAD(p) ribose binding residues [chemical binding]; other site 592029003290 NAD binding pocket [chemical binding]; other site 592029003291 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 592029003292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592029003293 catalytic loop [active] 592029003294 iron binding site [ion binding]; other site 592029003295 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 592029003296 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 592029003297 four helix bundle protein; Region: TIGR02436 592029003298 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 592029003299 Peptidase family M23; Region: Peptidase_M23; pfam01551 592029003300 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592029003301 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 592029003302 NAD binding site [chemical binding]; other site 592029003303 putative substrate binding site 2 [chemical binding]; other site 592029003304 putative substrate binding site 1 [chemical binding]; other site 592029003305 active site 592029003306 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 592029003307 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592029003308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029003309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029003310 active site 592029003311 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 592029003312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592029003313 AMP binding site [chemical binding]; other site 592029003314 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 592029003315 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 592029003316 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 592029003317 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 592029003318 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 592029003319 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592029003320 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592029003321 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029003322 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 592029003323 GIY-YIG motif/motif A; other site 592029003324 putative active site [active] 592029003325 putative metal binding site [ion binding]; other site 592029003326 MG2 domain; Region: A2M_N; pfam01835 592029003327 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 592029003328 Alpha-2-macroglobulin family; Region: A2M; pfam00207 592029003329 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 592029003330 surface patch; other site 592029003331 thioester region; other site 592029003332 specificity defining residues; other site 592029003333 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029003334 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 592029003335 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029003336 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 592029003337 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 592029003338 Zn binding site [ion binding]; other site 592029003339 ribonuclease P; Reviewed; Region: rnpA; PRK01903 592029003340 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 592029003341 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592029003342 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592029003343 protein binding site [polypeptide binding]; other site 592029003344 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 592029003345 Catalytic dyad [active] 592029003346 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029003347 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029003348 ligand binding site [chemical binding]; other site 592029003349 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029003350 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029003351 ligand binding site [chemical binding]; other site 592029003352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592029003353 dimerization interface [polypeptide binding]; other site 592029003354 putative DNA binding site [nucleotide binding]; other site 592029003355 putative Zn2+ binding site [ion binding]; other site 592029003356 Low molecular weight phosphatase family; Region: LMWPc; cl00105 592029003357 active site 592029003358 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 592029003359 arsenical-resistance protein; Region: acr3; TIGR00832 592029003360 Uncharacterized conserved protein [Function unknown]; Region: COG2442 592029003361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 592029003362 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 592029003363 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 592029003364 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 592029003365 active site 592029003366 catalytic site [active] 592029003367 hypothetical protein; Provisional; Region: PRK13688 592029003368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592029003369 Coenzyme A binding pocket [chemical binding]; other site 592029003370 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 592029003371 ribonuclease R; Region: RNase_R; TIGR02063 592029003372 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 592029003373 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592029003374 RNB domain; Region: RNB; pfam00773 592029003375 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 592029003376 RNA binding site [nucleotide binding]; other site 592029003377 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 592029003378 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592029003379 Dihydroneopterin aldolase; Region: FolB; pfam02152 592029003380 active site 592029003381 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 592029003382 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003383 active site 592029003384 HIGH motif; other site 592029003385 nucleotide binding site [chemical binding]; other site 592029003386 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003387 active site 592029003388 KMSKS motif; other site 592029003389 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 592029003390 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 592029003391 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 592029003392 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029003393 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 592029003394 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592029003395 HIGH motif; other site 592029003396 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592029003397 active site 592029003398 KMSKS motif; other site 592029003399 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 592029003400 Fatty acid desaturase; Region: FA_desaturase; pfam00487 592029003401 Di-iron ligands [ion binding]; other site 592029003402 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 592029003403 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 592029003404 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 592029003405 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 592029003406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029003407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029003408 S-adenosylmethionine binding site [chemical binding]; other site 592029003409 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 592029003410 DNA polymerase III subunit delta'; Validated; Region: PRK08485 592029003411 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 592029003412 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 592029003413 putative active site [active] 592029003414 Phosphoglycerate kinase; Region: PGK; pfam00162 592029003415 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 592029003416 substrate binding site [chemical binding]; other site 592029003417 hinge regions; other site 592029003418 ADP binding site [chemical binding]; other site 592029003419 catalytic site [active] 592029003420 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592029003421 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592029003422 catalytic residue [active] 592029003423 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029003424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029003425 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 592029003426 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592029003427 Peptidase family M23; Region: Peptidase_M23; pfam01551 592029003428 GH3 auxin-responsive promoter; Region: GH3; pfam03321 592029003429 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 592029003430 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 592029003431 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 592029003432 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 592029003433 NADP binding site [chemical binding]; other site 592029003434 active site 592029003435 putative substrate binding site [chemical binding]; other site 592029003436 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003437 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 592029003438 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 592029003439 NADP-binding site; other site 592029003440 homotetramer interface [polypeptide binding]; other site 592029003441 substrate binding site [chemical binding]; other site 592029003442 homodimer interface [polypeptide binding]; other site 592029003443 active site 592029003444 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 592029003445 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 592029003446 NADP binding site [chemical binding]; other site 592029003447 active site 592029003448 putative substrate binding site [chemical binding]; other site 592029003449 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592029003450 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 592029003451 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 592029003452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029003453 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029003454 active site 592029003455 catalytic triad [active] 592029003456 oxyanion hole [active] 592029003457 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 592029003458 putative acyl transferase; Provisional; Region: PRK10502 592029003459 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 592029003460 putative trimer interface [polypeptide binding]; other site 592029003461 putative active site [active] 592029003462 putative substrate binding site [chemical binding]; other site 592029003463 putative CoA binding site [chemical binding]; other site 592029003464 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592029003465 oxyanion hole [active] 592029003466 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592029003467 catalytic triad [active] 592029003468 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 592029003469 putative glycosyl transferase; Provisional; Region: PRK10307 592029003470 DNA protecting protein DprA; Region: dprA; TIGR00732 592029003471 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 592029003472 MepB protein; Region: MepB; cl01985 592029003473 Predicted membrane protein [Function unknown]; Region: COG4682 592029003474 yiaA/B two helix domain; Region: YiaAB; pfam05360 592029003475 yiaA/B two helix domain; Region: YiaAB; pfam05360 592029003476 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 592029003477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029003478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592029003479 non-specific DNA binding site [nucleotide binding]; other site 592029003480 salt bridge; other site 592029003481 sequence-specific DNA binding site [nucleotide binding]; other site 592029003482 AhpC/TSA family; Region: AhpC-TSA; pfam00578 592029003483 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029003484 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 592029003485 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 592029003486 putative active site [active] 592029003487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592029003488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029003489 Walker A/P-loop; other site 592029003490 ATP binding site [chemical binding]; other site 592029003491 Q-loop/lid; other site 592029003492 ABC transporter signature motif; other site 592029003493 Walker B; other site 592029003494 D-loop; other site 592029003495 H-loop/switch region; other site 592029003496 ATPase involved in DNA repair; Region: DUF3686; pfam12458 592029003497 AAA domain; Region: AAA_22; pfam13401 592029003498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029003499 Walker A motif; other site 592029003500 ATP binding site [chemical binding]; other site 592029003501 Walker B motif; other site 592029003502 arginine finger; other site 592029003503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 592029003504 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 592029003505 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 592029003506 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 592029003507 PspA/IM30 family; Region: PspA_IM30; pfam04012 592029003508 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592029003509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029003510 non-specific DNA binding site [nucleotide binding]; other site 592029003511 salt bridge; other site 592029003512 sequence-specific DNA binding site [nucleotide binding]; other site 592029003513 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592029003514 Catalytic site [active] 592029003515 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 592029003516 HNH endonuclease; Region: HNH_2; pfam13391 592029003517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592029003518 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 592029003519 dimer interface [polypeptide binding]; other site 592029003520 substrate binding site [chemical binding]; other site 592029003521 metal binding site [ion binding]; metal-binding site 592029003522 Ribosome-binding factor A; Region: RBFA; pfam02033 592029003523 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 592029003524 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029003525 FtsX-like permease family; Region: FtsX; pfam02687 592029003526 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 592029003527 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592029003528 FMN binding site [chemical binding]; other site 592029003529 active site 592029003530 catalytic residues [active] 592029003531 substrate binding site [chemical binding]; other site 592029003532 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 592029003533 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 592029003534 active site residue [active] 592029003535 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029003536 Interdomain contacts; other site 592029003537 Cytokine receptor motif; other site 592029003538 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 592029003539 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 592029003540 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 592029003541 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029003542 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003543 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029003544 Interdomain contacts; other site 592029003545 Cytokine receptor motif; other site 592029003546 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029003547 Interdomain contacts; other site 592029003548 Cytokine receptor motif; other site 592029003549 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 592029003550 heterodimerization interface [polypeptide binding]; other site 592029003551 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003552 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 592029003553 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 592029003554 hexamer interface [polypeptide binding]; other site 592029003555 Walker A motif; other site 592029003556 ATP binding site [chemical binding]; other site 592029003557 Walker B motif; other site 592029003558 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029003559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029003560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029003561 DNA binding residues [nucleotide binding] 592029003562 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029003563 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 592029003564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592029003565 putative acyl-acceptor binding pocket; other site 592029003566 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 592029003567 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 592029003568 active site 592029003569 HIGH motif; other site 592029003570 dimer interface [polypeptide binding]; other site 592029003571 KMSKS motif; other site 592029003572 PEGA domain; Region: PEGA; pfam08308 592029003573 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 592029003574 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 592029003575 Substrate-binding site [chemical binding]; other site 592029003576 Substrate specificity [chemical binding]; other site 592029003577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592029003578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029003579 active site 592029003580 phosphorylation site [posttranslational modification] 592029003581 intermolecular recognition site; other site 592029003582 dimerization interface [polypeptide binding]; other site 592029003583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592029003584 DNA binding site [nucleotide binding] 592029003585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029003586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029003587 dimer interface [polypeptide binding]; other site 592029003588 phosphorylation site [posttranslational modification] 592029003589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029003590 ATP binding site [chemical binding]; other site 592029003591 Mg2+ binding site [ion binding]; other site 592029003592 G-X-G motif; other site 592029003593 GLPGLI family protein; Region: GLPGLI; TIGR01200 592029003594 GLPGLI family protein; Region: GLPGLI; TIGR01200 592029003595 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 592029003596 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 592029003597 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 592029003598 TLC ATP/ADP transporter; Region: TLC; cl03940 592029003599 HEAT repeats; Region: HEAT_2; pfam13646 592029003600 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592029003601 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 592029003602 HemN C-terminal domain; Region: HemN_C; pfam06969 592029003603 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 592029003604 proline aminopeptidase P II; Provisional; Region: PRK10879 592029003605 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 592029003606 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 592029003607 active site 592029003608 C-N hydrolase family amidase; Provisional; Region: PRK10438 592029003609 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 592029003610 putative active site [active] 592029003611 catalytic triad [active] 592029003612 dimer interface [polypeptide binding]; other site 592029003613 multimer interface [polypeptide binding]; other site 592029003614 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592029003615 active site 592029003616 metal binding site [ion binding]; metal-binding site 592029003617 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 592029003618 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 592029003619 homotetramer interface [polypeptide binding]; other site 592029003620 ligand binding site [chemical binding]; other site 592029003621 catalytic site [active] 592029003622 NAD binding site [chemical binding]; other site 592029003623 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 592029003624 phosphate binding site [ion binding]; other site 592029003625 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 592029003626 AAA domain; Region: AAA_28; pfam13521 592029003627 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 592029003628 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 592029003629 hypothetical protein; Provisional; Region: PRK09256 592029003630 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 592029003631 catalytic nucleophile [active] 592029003632 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 592029003633 putative catalytic site [active] 592029003634 putative metal binding site [ion binding]; other site 592029003635 putative phosphate binding site [ion binding]; other site 592029003636 Predicted methyltransferases [General function prediction only]; Region: COG0313 592029003637 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 592029003638 putative SAM binding site [chemical binding]; other site 592029003639 putative homodimer interface [polypeptide binding]; other site 592029003640 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 592029003641 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029003642 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592029003643 active site 592029003644 oxyanion hole [active] 592029003645 catalytic triad [active] 592029003646 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592029003647 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592029003648 active site 592029003649 oxyanion hole [active] 592029003650 catalytic triad [active] 592029003651 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029003652 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029003653 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592029003654 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 592029003655 starch binding outer membrane protein SusD; Region: SusD; cd08977 592029003656 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 592029003657 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 592029003658 putative Iron-sulfur protein interface [polypeptide binding]; other site 592029003659 proximal heme binding site [chemical binding]; other site 592029003660 distal heme binding site [chemical binding]; other site 592029003661 putative dimer interface [polypeptide binding]; other site 592029003662 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 592029003663 L-aspartate oxidase; Provisional; Region: PRK06175 592029003664 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592029003665 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 592029003666 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 592029003667 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592029003668 methionine aminotransferase; Validated; Region: PRK09082 592029003669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592029003670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029003671 homodimer interface [polypeptide binding]; other site 592029003672 catalytic residue [active] 592029003673 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592029003674 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 592029003675 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 592029003676 trimer interface [polypeptide binding]; other site 592029003677 active site 592029003678 TPR repeat; Region: TPR_11; pfam13414 592029003679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029003680 binding surface 592029003681 TPR motif; other site 592029003682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029003683 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 592029003684 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 592029003685 active site 592029003686 Substrate binding site; other site 592029003687 Mg++ binding site; other site 592029003688 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 592029003689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029003690 TPR motif; other site 592029003691 binding surface 592029003692 TPR repeat; Region: TPR_11; pfam13414 592029003693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029003694 binding surface 592029003695 TPR motif; other site 592029003696 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 592029003697 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 592029003698 Peptidase family M23; Region: Peptidase_M23; pfam01551 592029003699 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 592029003700 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029003701 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 592029003702 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029003703 CHAT domain; Region: CHAT; pfam12770 592029003704 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592029003705 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 592029003706 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 592029003707 homodimer interface [polypeptide binding]; other site 592029003708 oligonucleotide binding site [chemical binding]; other site 592029003709 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592029003710 IHF - DNA interface [nucleotide binding]; other site 592029003711 IHF dimer interface [polypeptide binding]; other site 592029003712 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592029003713 helix-hairpin-helix signature motif; other site 592029003714 substrate binding pocket [chemical binding]; other site 592029003715 active site 592029003716 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 592029003717 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 592029003718 DNA binding and oxoG recognition site [nucleotide binding] 592029003719 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 592029003720 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592029003721 dimer interface [polypeptide binding]; other site 592029003722 ssDNA binding site [nucleotide binding]; other site 592029003723 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592029003724 Domain of unknown function DUF21; Region: DUF21; pfam01595 592029003725 gliding motility-associated protein GldE; Region: GldE; TIGR03520 592029003726 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592029003727 Transporter associated domain; Region: CorC_HlyC; smart01091 592029003728 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 592029003729 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592029003730 EamA-like transporter family; Region: EamA; pfam00892 592029003731 EamA-like transporter family; Region: EamA; pfam00892 592029003732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592029003733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592029003734 short chain dehydrogenase; Provisional; Region: PRK06500 592029003735 classical (c) SDRs; Region: SDR_c; cd05233 592029003736 NAD(P) binding site [chemical binding]; other site 592029003737 active site 592029003738 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 592029003739 VPS10 domain; Region: VPS10; smart00602 592029003740 VPS10 domain; Region: VPS10; smart00602 592029003741 Putative cyclase; Region: Cyclase; pfam04199 592029003742 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 592029003743 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 592029003744 Protein of unknown function (DUF419); Region: DUF419; pfam04237 592029003745 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 592029003746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029003747 Walker A/P-loop; other site 592029003748 ATP binding site [chemical binding]; other site 592029003749 Q-loop/lid; other site 592029003750 ABC transporter signature motif; other site 592029003751 Walker B; other site 592029003752 D-loop; other site 592029003753 H-loop/switch region; other site 592029003754 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029003755 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592029003756 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 592029003757 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 592029003758 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 592029003759 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 592029003760 Dodecin; Region: Dodecin; pfam07311 592029003761 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 592029003762 Glycoprotease family; Region: Peptidase_M22; pfam00814 592029003763 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592029003764 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592029003765 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 592029003766 dimer interface [polypeptide binding]; other site 592029003767 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029003768 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 592029003769 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592029003770 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592029003771 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029003772 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029003773 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029003774 FtsX-like permease family; Region: FtsX; pfam02687 592029003775 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029003776 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029003777 FtsX-like permease family; Region: FtsX; pfam02687 592029003778 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592029003779 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029003780 Walker A/P-loop; other site 592029003781 ATP binding site [chemical binding]; other site 592029003782 Q-loop/lid; other site 592029003783 ABC transporter signature motif; other site 592029003784 Walker B; other site 592029003785 D-loop; other site 592029003786 H-loop/switch region; other site 592029003787 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 592029003788 Protein of unknown function (DUF420); Region: DUF420; pfam04238 592029003789 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 592029003790 Cu(I) binding site [ion binding]; other site 592029003791 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 592029003792 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 592029003793 Subunit I/III interface [polypeptide binding]; other site 592029003794 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 592029003795 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 592029003796 Subunit I/III interface [polypeptide binding]; other site 592029003797 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 592029003798 UbiA prenyltransferase family; Region: UbiA; pfam01040 592029003799 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003800 active site 592029003801 HIGH motif; other site 592029003802 nucleotide binding site [chemical binding]; other site 592029003803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003804 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592029003805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003806 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003807 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029003808 active site 592029003809 KMSKS motif; other site 592029003810 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 592029003811 tRNA binding surface [nucleotide binding]; other site 592029003812 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 592029003813 FtsX-like permease family; Region: FtsX; pfam02687 592029003814 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 592029003815 Bacitracin resistance protein BacA; Region: BacA; pfam02673 592029003816 DinB family; Region: DinB; cl17821 592029003817 DinB superfamily; Region: DinB_2; pfam12867 592029003818 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592029003819 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592029003820 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592029003821 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592029003822 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592029003823 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029003824 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029003825 ligand binding site [chemical binding]; other site 592029003826 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 592029003827 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 592029003828 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 592029003829 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 592029003830 Bacterial Ig-like domain; Region: Big_5; pfam13205 592029003831 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 592029003832 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 592029003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029003834 Walker A motif; other site 592029003835 ATP binding site [chemical binding]; other site 592029003836 Walker B motif; other site 592029003837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592029003838 Clp protease; Region: CLP_protease; pfam00574 592029003839 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592029003840 oligomer interface [polypeptide binding]; other site 592029003841 active site residues [active] 592029003842 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 592029003843 Membrane protein of unknown function; Region: DUF360; pfam04020 592029003844 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 592029003845 catalytic triad [active] 592029003846 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 592029003847 PGAP1-like protein; Region: PGAP1; pfam07819 592029003848 acyl-CoA esterase; Provisional; Region: PRK10673 592029003849 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 592029003850 active site 592029003851 hydrophilic channel; other site 592029003852 dimerization interface [polypeptide binding]; other site 592029003853 catalytic residues [active] 592029003854 active site lid [active] 592029003855 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 592029003856 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 592029003857 ATP-NAD kinase; Region: NAD_kinase; pfam01513 592029003858 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029003859 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 592029003860 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 592029003861 catalytic residue [active] 592029003862 putative FPP diphosphate binding site; other site 592029003863 putative FPP binding hydrophobic cleft; other site 592029003864 dimer interface [polypeptide binding]; other site 592029003865 putative IPP diphosphate binding site; other site 592029003866 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 592029003867 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592029003868 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592029003869 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592029003870 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029003871 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 592029003872 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 592029003873 Selenoprotein S (SelS); Region: Selenoprotein_S; pfam06936 592029003874 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 592029003875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029003876 HAMP domain; Region: HAMP; pfam00672 592029003877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029003878 dimer interface [polypeptide binding]; other site 592029003879 phosphorylation site [posttranslational modification] 592029003880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029003881 ATP binding site [chemical binding]; other site 592029003882 Mg2+ binding site [ion binding]; other site 592029003883 G-X-G motif; other site 592029003884 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 592029003885 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 592029003886 phosphorylation site [posttranslational modification] 592029003887 dimer interface [polypeptide binding]; other site 592029003888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029003889 ATP binding site [chemical binding]; other site 592029003890 Mg2+ binding site [ion binding]; other site 592029003891 G-X-G motif; other site 592029003892 Disulphide isomerase; Region: Disulph_isomer; pfam06491 592029003893 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 592029003894 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592029003895 putative acyl-acceptor binding pocket; other site 592029003896 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 592029003897 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 592029003898 homodimer interface [polypeptide binding]; other site 592029003899 putative substrate binding pocket [chemical binding]; other site 592029003900 diiron center [ion binding]; other site 592029003901 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 592029003902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029003903 ATP binding site [chemical binding]; other site 592029003904 putative Mg++ binding site [ion binding]; other site 592029003905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029003906 nucleotide binding region [chemical binding]; other site 592029003907 ATP-binding site [chemical binding]; other site 592029003908 RQC domain; Region: RQC; pfam09382 592029003909 HRDC domain; Region: HRDC; pfam00570 592029003910 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 592029003911 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592029003912 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 592029003913 DHH family; Region: DHH; pfam01368 592029003914 DHHA1 domain; Region: DHHA1; pfam02272 592029003915 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592029003916 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 592029003917 putative active site [active] 592029003918 putative metal binding site [ion binding]; other site 592029003919 Divergent AAA domain; Region: AAA_4; pfam04326 592029003920 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 592029003921 active site 592029003922 metal binding site [ion binding]; metal-binding site 592029003923 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029003924 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 592029003925 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 592029003926 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 592029003927 ADP-ribose binding site [chemical binding]; other site 592029003928 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 592029003929 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 592029003930 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 592029003931 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 592029003932 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 592029003933 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 592029003934 substrate binding site [chemical binding]; other site 592029003935 active site 592029003936 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 592029003937 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 592029003938 active site 592029003939 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592029003940 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592029003941 ligand binding site [chemical binding]; other site 592029003942 hypothetical protein; Provisional; Region: PRK11820 592029003943 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 592029003944 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 592029003945 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 592029003946 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 592029003947 catalytic site [active] 592029003948 G-X2-G-X-G-K; other site 592029003949 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 592029003950 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 592029003951 active site 592029003952 (T/H)XGH motif; other site 592029003953 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 592029003954 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 592029003955 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 592029003956 FeoA domain; Region: FeoA; pfam04023 592029003957 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 592029003958 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592029003959 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 592029003960 intersubunit interface [polypeptide binding]; other site 592029003961 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 592029003962 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 592029003963 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592029003964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592029003965 ABC-ATPase subunit interface; other site 592029003966 dimer interface [polypeptide binding]; other site 592029003967 putative PBP binding regions; other site 592029003968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592029003969 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592029003970 ABC-ATPase subunit interface; other site 592029003971 dimer interface [polypeptide binding]; other site 592029003972 putative PBP binding regions; other site 592029003973 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 592029003974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592029003975 substrate binding site [chemical binding]; other site 592029003976 oxyanion hole (OAH) forming residues; other site 592029003977 trimer interface [polypeptide binding]; other site 592029003978 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 592029003979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029003980 active site 592029003981 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 592029003982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029003983 S-adenosylmethionine binding site [chemical binding]; other site 592029003984 glycyl-tRNA synthetase; Provisional; Region: PRK04173 592029003985 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592029003986 motif 1; other site 592029003987 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 592029003988 active site 592029003989 motif 2; other site 592029003990 motif 3; other site 592029003991 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 592029003992 anticodon binding site; other site 592029003993 Colicin V production protein; Region: Colicin_V; pfam02674 592029003994 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 592029003995 active site 592029003996 catalytic site [active] 592029003997 substrate binding site [chemical binding]; other site 592029003998 Protein of unknown function (DUF458); Region: DUF458; cl00861 592029003999 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 592029004000 AAA domain; Region: AAA_11; pfam13086 592029004001 Part of AAA domain; Region: AAA_19; pfam13245 592029004002 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 592029004003 AAA domain; Region: AAA_12; pfam13087 592029004004 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 592029004005 Peptidase family M48; Region: Peptidase_M48; cl12018 592029004006 Peptidase family M48; Region: Peptidase_M48; cl12018 592029004007 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 592029004008 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 592029004009 HflX GTPase family; Region: HflX; cd01878 592029004010 G1 box; other site 592029004011 GTP/Mg2+ binding site [chemical binding]; other site 592029004012 Switch I region; other site 592029004013 G2 box; other site 592029004014 G3 box; other site 592029004015 Switch II region; other site 592029004016 G4 box; other site 592029004017 G5 box; other site 592029004018 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 592029004019 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 592029004020 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 592029004021 putative active site [active] 592029004022 Zn binding site [ion binding]; other site 592029004023 methionine gamma-lyase; Validated; Region: PRK07049 592029004024 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592029004025 homodimer interface [polypeptide binding]; other site 592029004026 substrate-cofactor binding pocket; other site 592029004027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029004028 catalytic residue [active] 592029004029 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 592029004030 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592029004031 Domain of unknown function DUF21; Region: DUF21; pfam01595 592029004032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592029004033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592029004034 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592029004035 Sporulation related domain; Region: SPOR; pfam05036 592029004036 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 592029004037 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 592029004038 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 592029004039 dimer interface [polypeptide binding]; other site 592029004040 motif 1; other site 592029004041 active site 592029004042 motif 2; other site 592029004043 motif 3; other site 592029004044 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 592029004045 Fasciclin domain; Region: Fasciclin; pfam02469 592029004046 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 592029004047 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 592029004048 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 592029004049 domain interfaces; other site 592029004050 active site 592029004051 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 592029004052 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 592029004053 tRNA; other site 592029004054 putative tRNA binding site [nucleotide binding]; other site 592029004055 putative NADP binding site [chemical binding]; other site 592029004056 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 592029004057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592029004058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029004059 Helix-turn-helix domain; Region: HTH_18; pfam12833 592029004060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029004061 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029004062 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029004063 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 592029004064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029004065 ATP binding site [chemical binding]; other site 592029004066 putative Mg++ binding site [ion binding]; other site 592029004067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029004068 nucleotide binding region [chemical binding]; other site 592029004069 ATP-binding site [chemical binding]; other site 592029004070 DEAD/H associated; Region: DEAD_assoc; pfam08494 592029004071 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 592029004072 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 592029004073 TPP-binding site [chemical binding]; other site 592029004074 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 592029004075 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 592029004076 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592029004077 E3 interaction surface; other site 592029004078 lipoyl attachment site [posttranslational modification]; other site 592029004079 e3 binding domain; Region: E3_binding; pfam02817 592029004080 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592029004081 Acyl transferase domain; Region: Acyl_transf_1; cl08282 592029004082 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 592029004083 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 592029004084 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592029004085 2TM domain; Region: 2TM; pfam13239 592029004086 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 592029004087 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 592029004088 folate binding site [chemical binding]; other site 592029004089 NADP+ binding site [chemical binding]; other site 592029004090 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 592029004091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592029004092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029004093 catalytic residue [active] 592029004094 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029004095 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 592029004096 active site 592029004097 catalytic residues [active] 592029004098 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004099 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029004100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029004101 S-adenosylmethionine binding site [chemical binding]; other site 592029004102 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 592029004103 DNA polymerase I; Provisional; Region: PRK05755 592029004104 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 592029004105 active site 592029004106 metal binding site 1 [ion binding]; metal-binding site 592029004107 putative 5' ssDNA interaction site; other site 592029004108 metal binding site 3; metal-binding site 592029004109 metal binding site 2 [ion binding]; metal-binding site 592029004110 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 592029004111 putative DNA binding site [nucleotide binding]; other site 592029004112 putative metal binding site [ion binding]; other site 592029004113 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 592029004114 active site 592029004115 catalytic site [active] 592029004116 substrate binding site [chemical binding]; other site 592029004117 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 592029004118 active site 592029004119 DNA binding site [nucleotide binding] 592029004120 catalytic site [active] 592029004121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029004122 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 592029004123 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029004124 H+ Antiporter protein; Region: 2A0121; TIGR00900 592029004125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029004126 putative substrate translocation pore; other site 592029004127 phosphodiesterase YaeI; Provisional; Region: PRK11340 592029004128 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 592029004129 putative active site [active] 592029004130 putative metal binding site [ion binding]; other site 592029004131 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029004132 catalytic residues [active] 592029004133 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592029004134 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 592029004135 NodB motif; other site 592029004136 active site 592029004137 catalytic site [active] 592029004138 metal binding site [ion binding]; metal-binding site 592029004139 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 592029004140 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 592029004141 Helix-turn-helix domain; Region: HTH_17; pfam12728 592029004142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592029004143 active site 592029004144 DNA binding site [nucleotide binding] 592029004145 Int/Topo IB signature motif; other site 592029004146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029004147 Ligand Binding Site [chemical binding]; other site 592029004148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592029004149 Ligand Binding Site [chemical binding]; other site 592029004150 ribosome maturation protein RimP; Reviewed; Region: PRK00092 592029004151 Sm and related proteins; Region: Sm_like; cl00259 592029004152 heptamer interface [polypeptide binding]; other site 592029004153 Sm1 motif; other site 592029004154 hexamer interface [polypeptide binding]; other site 592029004155 RNA binding site [nucleotide binding]; other site 592029004156 Sm2 motif; other site 592029004157 transcription termination factor NusA; Region: NusA; TIGR01953 592029004158 NusA N-terminal domain; Region: NusA_N; pfam08529 592029004159 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 592029004160 RNA binding site [nucleotide binding]; other site 592029004161 homodimer interface [polypeptide binding]; other site 592029004162 NusA-like KH domain; Region: KH_5; pfam13184 592029004163 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 592029004164 G-X-X-G motif; other site 592029004165 translation initiation factor IF-2; Region: IF-2; TIGR00487 592029004166 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 592029004167 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 592029004168 G1 box; other site 592029004169 putative GEF interaction site [polypeptide binding]; other site 592029004170 GTP/Mg2+ binding site [chemical binding]; other site 592029004171 Switch I region; other site 592029004172 G2 box; other site 592029004173 G3 box; other site 592029004174 Switch II region; other site 592029004175 G4 box; other site 592029004176 G5 box; other site 592029004177 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 592029004178 Translation-initiation factor 2; Region: IF-2; pfam11987 592029004179 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 592029004180 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 592029004181 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 592029004182 dimer interface [polypeptide binding]; other site 592029004183 catalytic triad [active] 592029004184 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 592029004185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 592029004186 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004187 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 592029004188 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 592029004189 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 592029004190 active site 592029004191 HIGH motif; other site 592029004192 KMSKS motif; other site 592029004193 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 592029004194 tRNA binding surface [nucleotide binding]; other site 592029004195 anticodon binding site; other site 592029004196 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 592029004197 dimer interface [polypeptide binding]; other site 592029004198 putative tRNA-binding site [nucleotide binding]; other site 592029004199 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029004200 Bacterial SH3 domain; Region: SH3_3; pfam08239 592029004201 Pirin-related protein [General function prediction only]; Region: COG1741 592029004202 Pirin; Region: Pirin; pfam02678 592029004203 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 592029004204 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029004205 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029004206 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029004207 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029004208 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 592029004209 Peptidase family M28; Region: Peptidase_M28; pfam04389 592029004210 metal binding site [ion binding]; metal-binding site 592029004211 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592029004212 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 592029004213 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 592029004214 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029004215 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029004216 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029004217 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 592029004218 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 592029004219 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 592029004220 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592029004221 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 592029004222 nucleotide binding site/active site [active] 592029004223 HIT family signature motif; other site 592029004224 catalytic residue [active] 592029004225 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 592029004226 nucleoside/Zn binding site; other site 592029004227 dimer interface [polypeptide binding]; other site 592029004228 catalytic motif [active] 592029004229 Gram-negative bacterial tonB protein; Region: TonB; cl10048 592029004230 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 592029004231 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 592029004232 TPP-binding site; other site 592029004233 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592029004234 PYR/PP interface [polypeptide binding]; other site 592029004235 dimer interface [polypeptide binding]; other site 592029004236 TPP binding site [chemical binding]; other site 592029004237 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592029004238 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004239 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 592029004240 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029004241 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 592029004242 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029004243 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029004244 Phosphate transporter family; Region: PHO4; cl00396 592029004245 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592029004246 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592029004247 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592029004248 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029004249 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 592029004250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592029004251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592029004252 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592029004253 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592029004254 substrate binding pocket [chemical binding]; other site 592029004255 chain length determination region; other site 592029004256 substrate-Mg2+ binding site; other site 592029004257 catalytic residues [active] 592029004258 aspartate-rich region 1; other site 592029004259 active site lid residues [active] 592029004260 aspartate-rich region 2; other site 592029004261 ATP-dependent DNA ligase; Validated; Region: PRK09247 592029004262 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 592029004263 active site 592029004264 DNA binding site [nucleotide binding] 592029004265 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 592029004266 DNA binding site [nucleotide binding] 592029004267 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 592029004268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592029004269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592029004270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029004271 NAD(P) binding site [chemical binding]; other site 592029004272 active site 592029004273 Tellurite resistance protein TerB; Region: TerB; cl17311 592029004274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029004275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029004276 dimer interface [polypeptide binding]; other site 592029004277 phosphorylation site [posttranslational modification] 592029004278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029004279 ATP binding site [chemical binding]; other site 592029004280 Mg2+ binding site [ion binding]; other site 592029004281 G-X-G motif; other site 592029004282 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592029004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029004284 active site 592029004285 phosphorylation site [posttranslational modification] 592029004286 intermolecular recognition site; other site 592029004287 dimerization interface [polypeptide binding]; other site 592029004288 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 592029004289 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 592029004290 Rab subfamily motif 1 (RabSF1); other site 592029004291 G1 box; other site 592029004292 GTP/Mg2+ binding site [chemical binding]; other site 592029004293 Rab subfamily motif 2 (RabSF2); other site 592029004294 Switch I region; other site 592029004295 G2 box; other site 592029004296 effector interaction site; other site 592029004297 GDI interaction site; other site 592029004298 Rab family motif 1 (RabF1); other site 592029004299 GEF interaction site [polypeptide binding]; other site 592029004300 Rab family motif 2 (RabF2); other site 592029004301 G3 box; other site 592029004302 Switch II region; other site 592029004303 Rab family motif 3 (RabF3); other site 592029004304 Rab family motif 4 (RabF4); other site 592029004305 Rab family motif 5 (RabF5); other site 592029004306 Rab subfamily motif 3 (RabSF3); other site 592029004307 G4 box; other site 592029004308 G5 box; other site 592029004309 Rab subfamily motif 4 (RabSF4); other site 592029004310 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 592029004311 AMP binding site [chemical binding]; other site 592029004312 metal binding site [ion binding]; metal-binding site 592029004313 active site 592029004314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592029004315 Coenzyme A binding pocket [chemical binding]; other site 592029004316 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 592029004317 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 592029004318 nucleotide binding site [chemical binding]; other site 592029004319 substrate binding site [chemical binding]; other site 592029004320 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 592029004321 putative acyl-acceptor binding pocket; other site 592029004322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 592029004323 Low molecular weight phosphatase family; Region: LMWPc; cl00105 592029004324 active site 592029004325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592029004326 active site 592029004327 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592029004328 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 592029004329 putative ligand binding site [chemical binding]; other site 592029004330 putative NAD binding site [chemical binding]; other site 592029004331 catalytic site [active] 592029004332 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 592029004333 MgtE intracellular N domain; Region: MgtE_N; smart00924 592029004334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 592029004335 Divalent cation transporter; Region: MgtE; pfam01769 592029004336 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 592029004337 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592029004338 active site 592029004339 catalytic site [active] 592029004340 substrate binding site [chemical binding]; other site 592029004341 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 592029004342 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 592029004343 active site 592029004344 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 592029004345 generic binding surface II; other site 592029004346 generic binding surface I; other site 592029004347 S-adenosylmethionine synthetase; Validated; Region: PRK05250 592029004348 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 592029004349 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 592029004350 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 592029004351 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 592029004352 Rrf2 family protein; Region: rrf2_super; TIGR00738 592029004353 Transcriptional regulator; Region: Rrf2; pfam02082 592029004354 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592029004355 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029004356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029004357 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 592029004358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592029004359 catalytic loop [active] 592029004360 iron binding site [ion binding]; other site 592029004361 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 592029004362 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 592029004363 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 592029004364 substrate binding pocket [chemical binding]; other site 592029004365 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 592029004366 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 592029004367 putative active site [active] 592029004368 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 592029004369 B12 binding site [chemical binding]; other site 592029004370 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 592029004371 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 592029004372 FAD binding site [chemical binding]; other site 592029004373 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 592029004374 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 592029004375 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 592029004376 putative active site [active] 592029004377 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 592029004378 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 592029004379 active site 592029004380 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 592029004381 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029004382 Zn2+ binding site [ion binding]; other site 592029004383 Mg2+ binding site [ion binding]; other site 592029004384 Predicted transcriptional regulators [Transcription]; Region: COG1510 592029004385 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 592029004386 TIGR01777 family protein; Region: yfcH 592029004387 putative NAD(P) binding site [chemical binding]; other site 592029004388 putative active site [active] 592029004389 RDD family; Region: RDD; pfam06271 592029004390 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 592029004391 Peptidase family M1; Region: Peptidase_M1; pfam01433 592029004392 Zn binding site [ion binding]; other site 592029004393 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 592029004394 Fic/DOC family; Region: Fic; cl00960 592029004395 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 592029004396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029004397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029004398 4Fe-4S binding domain; Region: Fer4_5; pfam12801 592029004399 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 592029004400 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592029004401 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 592029004402 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 592029004403 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 592029004404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 592029004405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029004406 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 592029004407 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 592029004408 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 592029004409 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 592029004410 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 592029004411 active site 592029004412 intersubunit interface [polypeptide binding]; other site 592029004413 zinc binding site [ion binding]; other site 592029004414 Na+ binding site [ion binding]; other site 592029004415 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029004416 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 592029004417 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592029004418 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029004419 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 592029004420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029004421 S-adenosylmethionine binding site [chemical binding]; other site 592029004422 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 592029004423 TrkA-N domain; Region: TrkA_N; pfam02254 592029004424 TrkA-C domain; Region: TrkA_C; pfam02080 592029004425 TrkA-N domain; Region: TrkA_N; pfam02254 592029004426 TrkA-C domain; Region: TrkA_C; pfam02080 592029004427 Cation transport protein; Region: TrkH; cl17365 592029004428 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 592029004429 aspartate aminotransferase; Provisional; Region: PRK05764 592029004430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592029004431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029004432 homodimer interface [polypeptide binding]; other site 592029004433 catalytic residue [active] 592029004434 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 592029004435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029004436 S-adenosylmethionine binding site [chemical binding]; other site 592029004437 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029004438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029004439 catalytic residues [active] 592029004440 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 592029004441 Outer membrane protein Omp28; Region: Omp28; pfam11551 592029004442 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 592029004443 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 592029004444 Glutamate binding site [chemical binding]; other site 592029004445 NAD binding site [chemical binding]; other site 592029004446 catalytic residues [active] 592029004447 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 592029004448 Double zinc ribbon; Region: DZR; pfam12773 592029004449 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 592029004450 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 592029004451 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 592029004452 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 592029004453 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 592029004454 FMN-binding domain; Region: FMN_bind; cl01081 592029004455 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 592029004456 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 592029004457 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 592029004458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592029004459 catalytic loop [active] 592029004460 iron binding site [ion binding]; other site 592029004461 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 592029004462 FAD binding pocket [chemical binding]; other site 592029004463 FAD binding motif [chemical binding]; other site 592029004464 phosphate binding motif [ion binding]; other site 592029004465 beta-alpha-beta structure motif; other site 592029004466 NAD binding pocket [chemical binding]; other site 592029004467 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 592029004468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 592029004469 Histidine kinase; Region: HisKA_3; pfam07730 592029004470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029004471 ATP binding site [chemical binding]; other site 592029004472 Mg2+ binding site [ion binding]; other site 592029004473 G-X-G motif; other site 592029004474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029004475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029004476 active site 592029004477 phosphorylation site [posttranslational modification] 592029004478 intermolecular recognition site; other site 592029004479 dimerization interface [polypeptide binding]; other site 592029004480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029004481 DNA binding residues [nucleotide binding] 592029004482 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029004483 intermolecular salt bridges; other site 592029004484 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029004485 Family description; Region: VCBS; pfam13517 592029004486 Family description; Region: VCBS; pfam13517 592029004487 Family description; Region: VCBS; pfam13517 592029004488 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004489 Helix-turn-helix domain; Region: HTH_18; pfam12833 592029004490 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 592029004491 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029004492 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029004493 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 592029004494 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 592029004495 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 592029004496 ligand binding surface [chemical binding]; other site 592029004497 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 592029004498 ligand binding surface [chemical binding]; other site 592029004499 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029004500 intermolecular salt bridges; other site 592029004501 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004502 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 592029004503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029004504 putative substrate translocation pore; other site 592029004505 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 592029004506 active site 592029004507 dimer interface [polypeptide binding]; other site 592029004508 catalytic nucleophile [active] 592029004509 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592029004510 homotrimer interaction site [polypeptide binding]; other site 592029004511 putative active site [active] 592029004512 Transposase IS200 like; Region: Y1_Tnp; cl00848 592029004513 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592029004514 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 592029004515 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 592029004516 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592029004517 kynureninase; Region: kynureninase; TIGR01814 592029004518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029004519 catalytic residue [active] 592029004520 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 592029004521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029004522 putative substrate translocation pore; other site 592029004523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592029004524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029004525 active site 592029004526 phosphorylation site [posttranslational modification] 592029004527 intermolecular recognition site; other site 592029004528 dimerization interface [polypeptide binding]; other site 592029004529 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592029004530 DNA binding site [nucleotide binding] 592029004531 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 592029004532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592029004533 dimerization interface [polypeptide binding]; other site 592029004534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029004535 dimer interface [polypeptide binding]; other site 592029004536 phosphorylation site [posttranslational modification] 592029004537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029004538 ATP binding site [chemical binding]; other site 592029004539 Mg2+ binding site [ion binding]; other site 592029004540 G-X-G motif; other site 592029004541 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 592029004542 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 592029004543 oligomer interface [polypeptide binding]; other site 592029004544 RNA binding site [nucleotide binding]; other site 592029004545 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 592029004546 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 592029004547 RNase E interface [polypeptide binding]; other site 592029004548 trimer interface [polypeptide binding]; other site 592029004549 active site 592029004550 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 592029004551 putative nucleic acid binding region [nucleotide binding]; other site 592029004552 G-X-X-G motif; other site 592029004553 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 592029004554 RNA binding site [nucleotide binding]; other site 592029004555 domain interface; other site 592029004556 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 592029004557 16S/18S rRNA binding site [nucleotide binding]; other site 592029004558 S13e-L30e interaction site [polypeptide binding]; other site 592029004559 25S rRNA binding site [nucleotide binding]; other site 592029004560 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 592029004561 purine nucleoside phosphorylase; Provisional; Region: PRK08202 592029004562 Protein of unknown function, DUF547; Region: DUF547; pfam04784 592029004563 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 592029004564 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 592029004565 Probable Catalytic site; other site 592029004566 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 592029004567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592029004568 Walker A/P-loop; other site 592029004569 ATP binding site [chemical binding]; other site 592029004570 Q-loop/lid; other site 592029004571 ABC transporter signature motif; other site 592029004572 Walker B; other site 592029004573 D-loop; other site 592029004574 H-loop/switch region; other site 592029004575 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 592029004576 Prephenate dehydratase; Region: PDT; pfam00800 592029004577 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 592029004578 putative L-Phe binding site [chemical binding]; other site 592029004579 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 592029004580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592029004581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029004582 homodimer interface [polypeptide binding]; other site 592029004583 catalytic residue [active] 592029004584 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 592029004585 prephenate dehydrogenase; Validated; Region: PRK08507 592029004586 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 592029004587 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 592029004588 Chorismate mutase type II; Region: CM_2; smart00830 592029004589 GTPase RsgA; Reviewed; Region: PRK00098 592029004590 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 592029004591 RNA binding site [nucleotide binding]; other site 592029004592 homodimer interface [polypeptide binding]; other site 592029004593 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 592029004594 GTPase/Zn-binding domain interface [polypeptide binding]; other site 592029004595 GTP/Mg2+ binding site [chemical binding]; other site 592029004596 G4 box; other site 592029004597 G5 box; other site 592029004598 G1 box; other site 592029004599 Switch I region; other site 592029004600 G2 box; other site 592029004601 G3 box; other site 592029004602 Switch II region; other site 592029004603 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 592029004604 putative active site [active] 592029004605 dimerization interface [polypeptide binding]; other site 592029004606 putative tRNAtyr binding site [nucleotide binding]; other site 592029004607 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 592029004608 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 592029004609 homodimer interface [polypeptide binding]; other site 592029004610 metal binding site [ion binding]; metal-binding site 592029004611 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 592029004612 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 592029004613 putative active site [active] 592029004614 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 592029004615 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 592029004616 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 592029004617 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 592029004618 substrate binding site [chemical binding]; other site 592029004619 hexamer interface [polypeptide binding]; other site 592029004620 metal binding site [ion binding]; metal-binding site 592029004621 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 592029004622 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592029004623 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 592029004624 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592029004625 protein binding site [polypeptide binding]; other site 592029004626 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 592029004627 Catalytic dyad [active] 592029004628 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 592029004629 catalytic motif [active] 592029004630 Zn binding site [ion binding]; other site 592029004631 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 592029004632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029004633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029004634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029004635 dimer interface [polypeptide binding]; other site 592029004636 phosphorylation site [posttranslational modification] 592029004637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029004638 ATP binding site [chemical binding]; other site 592029004639 Mg2+ binding site [ion binding]; other site 592029004640 G-X-G motif; other site 592029004641 Response regulator receiver domain; Region: Response_reg; pfam00072 592029004642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029004643 active site 592029004644 phosphorylation site [posttranslational modification] 592029004645 intermolecular recognition site; other site 592029004646 dimerization interface [polypeptide binding]; other site 592029004647 FOG: CBS domain [General function prediction only]; Region: COG0517 592029004648 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 592029004649 Sensors of blue-light using FAD; Region: BLUF; pfam04940 592029004650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592029004651 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592029004652 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 592029004653 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 592029004654 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 592029004655 active site 592029004656 homodimer interface [polypeptide binding]; other site 592029004657 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 592029004658 putative acyl-acceptor binding pocket; other site 592029004659 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592029004660 active site 592029004661 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 592029004662 catalytic motif [active] 592029004663 Catalytic residue [active] 592029004664 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 592029004665 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029004666 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592029004667 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 592029004668 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 592029004669 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 592029004670 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 592029004671 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592029004672 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 592029004673 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 592029004674 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 592029004675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592029004676 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 592029004677 FAD binding site [chemical binding]; other site 592029004678 homotetramer interface [polypeptide binding]; other site 592029004679 substrate binding pocket [chemical binding]; other site 592029004680 catalytic base [active] 592029004681 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 592029004682 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 592029004683 NAD binding site [chemical binding]; other site 592029004684 homodimer interface [polypeptide binding]; other site 592029004685 active site 592029004686 substrate binding site [chemical binding]; other site 592029004687 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004688 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 592029004689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592029004690 FeS/SAM binding site; other site 592029004691 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 592029004692 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029004693 Interdomain contacts; other site 592029004694 Cytokine receptor motif; other site 592029004695 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004696 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592029004698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592029004699 substrate binding pocket [chemical binding]; other site 592029004700 chain length determination region; other site 592029004701 substrate-Mg2+ binding site; other site 592029004702 catalytic residues [active] 592029004703 aspartate-rich region 1; other site 592029004704 active site lid residues [active] 592029004705 aspartate-rich region 2; other site 592029004706 GTP-binding protein Der; Reviewed; Region: PRK00093 592029004707 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 592029004708 G1 box; other site 592029004709 GTP/Mg2+ binding site [chemical binding]; other site 592029004710 Switch I region; other site 592029004711 G2 box; other site 592029004712 Switch II region; other site 592029004713 G3 box; other site 592029004714 G4 box; other site 592029004715 G5 box; other site 592029004716 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 592029004717 G1 box; other site 592029004718 GTP/Mg2+ binding site [chemical binding]; other site 592029004719 Switch I region; other site 592029004720 G2 box; other site 592029004721 G3 box; other site 592029004722 Switch II region; other site 592029004723 G4 box; other site 592029004724 G5 box; other site 592029004725 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029004726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029004727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 592029004728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029004729 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 592029004730 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592029004731 DXD motif; other site 592029004732 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 592029004733 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592029004734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592029004735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029004736 non-specific DNA binding site [nucleotide binding]; other site 592029004737 salt bridge; other site 592029004738 sequence-specific DNA binding site [nucleotide binding]; other site 592029004739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 592029004740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592029004741 Coenzyme A binding pocket [chemical binding]; other site 592029004742 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592029004743 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 592029004744 putative active site [active] 592029004745 catalytic triad [active] 592029004746 putative dimer interface [polypeptide binding]; other site 592029004747 Deoxyhypusine synthase; Region: DS; cl00826 592029004748 Deoxyhypusine synthase; Region: DS; cl00826 592029004749 agmatinase; Region: agmatinase; TIGR01230 592029004750 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 592029004751 putative active site [active] 592029004752 Mn binding site [ion binding]; other site 592029004753 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 592029004754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 592029004755 dimer interface [polypeptide binding]; other site 592029004756 active site 592029004757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592029004758 catalytic residues [active] 592029004759 substrate binding site [chemical binding]; other site 592029004760 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 592029004761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592029004762 RNA binding surface [nucleotide binding]; other site 592029004763 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 592029004764 active site 592029004765 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029004766 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029004767 FtsX-like permease family; Region: FtsX; pfam02687 592029004768 diphosphomevalonate decarboxylase; Region: PLN02407 592029004769 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 592029004770 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 592029004771 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 592029004772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 592029004773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592029004774 Predicted acetyltransferase [General function prediction only]; Region: COG2388 592029004775 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 592029004776 active site pocket [active] 592029004777 oxyanion hole [active] 592029004778 catalytic triad [active] 592029004779 active site nucleophile [active] 592029004780 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029004781 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 592029004782 Zn binding site [ion binding]; other site 592029004783 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 592029004784 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592029004785 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592029004786 active site 592029004787 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 592029004788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029004789 S-adenosylmethionine binding site [chemical binding]; other site 592029004790 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 592029004791 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 592029004792 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592029004793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592029004794 rod shape-determining protein MreC; Provisional; Region: PRK13922 592029004795 rod shape-determining protein MreC; Region: MreC; pfam04085 592029004796 rod shape-determining protein MreB; Provisional; Region: PRK13927 592029004797 MreB and similar proteins; Region: MreB_like; cd10225 592029004798 nucleotide binding site [chemical binding]; other site 592029004799 Mg binding site [ion binding]; other site 592029004800 putative protofilament interaction site [polypeptide binding]; other site 592029004801 RodZ interaction site [polypeptide binding]; other site 592029004802 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 592029004803 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 592029004804 purine monophosphate binding site [chemical binding]; other site 592029004805 dimer interface [polypeptide binding]; other site 592029004806 putative catalytic residues [active] 592029004807 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 592029004808 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 592029004809 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 592029004810 active site 592029004811 catalytic triad [active] 592029004812 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 592029004813 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004814 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 592029004815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592029004816 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029004817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029004818 binding surface 592029004819 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029004820 TPR motif; other site 592029004821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029004822 binding surface 592029004823 TPR motif; other site 592029004824 Nnf1; Region: Nnf1; pfam03980 592029004825 MG2 domain; Region: A2M_N; pfam01835 592029004826 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029004827 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592029004828 Alpha-2-macroglobulin family; Region: A2M; pfam00207 592029004829 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 592029004830 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 592029004831 putative active site [active] 592029004832 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 592029004833 UbiA prenyltransferase family; Region: UbiA; pfam01040 592029004834 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 592029004835 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592029004836 putative active site [active] 592029004837 catalytic triad [active] 592029004838 putative dimer interface [polypeptide binding]; other site 592029004839 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 592029004840 SurA N-terminal domain; Region: SurA_N_3; cl07813 592029004841 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 592029004842 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592029004843 Domain of unknown function DUF21; Region: DUF21; pfam01595 592029004844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592029004845 Transporter associated domain; Region: CorC_HlyC; smart01091 592029004846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592029004847 TPR motif; other site 592029004848 binding surface 592029004849 Type III pantothenate kinase; Region: Pan_kinase; cl17198 592029004850 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592029004851 active site 592029004852 Int/Topo IB signature motif; other site 592029004853 DNA binding site [nucleotide binding] 592029004854 Helix-turn-helix domain; Region: HTH_17; pfam12728 592029004855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029004856 non-specific DNA binding site [nucleotide binding]; other site 592029004857 salt bridge; other site 592029004858 sequence-specific DNA binding site [nucleotide binding]; other site 592029004859 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592029004860 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 592029004861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029004862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592029004863 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 592029004864 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 592029004865 active site 592029004866 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004867 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 592029004868 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 592029004869 active site 592029004870 catalytic motif [active] 592029004871 Zn binding site [ion binding]; other site 592029004872 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 592029004873 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592029004874 tetramer interface [polypeptide binding]; other site 592029004875 TPP-binding site [chemical binding]; other site 592029004876 heterodimer interface [polypeptide binding]; other site 592029004877 phosphorylation loop region [posttranslational modification] 592029004878 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592029004879 E3 interaction surface; other site 592029004880 lipoyl attachment site [posttranslational modification]; other site 592029004881 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592029004882 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 592029004883 E3 interaction surface; other site 592029004884 lipoyl attachment site [posttranslational modification]; other site 592029004885 e3 binding domain; Region: E3_binding; pfam02817 592029004886 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592029004887 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 592029004888 Peptidase family M28; Region: Peptidase_M28; pfam04389 592029004889 metal binding site [ion binding]; metal-binding site 592029004890 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 592029004891 classical (c) SDRs; Region: SDR_c; cd05233 592029004892 NAD(P) binding site [chemical binding]; other site 592029004893 active site 592029004894 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 592029004895 ATP-grasp domain; Region: ATP-grasp; pfam02222 592029004896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029004897 active site 592029004898 adenylate kinase; Reviewed; Region: adk; PRK00279 592029004899 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 592029004900 AMP-binding site [chemical binding]; other site 592029004901 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 592029004902 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 592029004903 starch binding site [chemical binding]; other site 592029004904 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 592029004905 starch binding site [chemical binding]; other site 592029004906 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004907 GTPase CgtA; Reviewed; Region: obgE; PRK12299 592029004908 GTP1/OBG; Region: GTP1_OBG; pfam01018 592029004909 Obg GTPase; Region: Obg; cd01898 592029004910 G1 box; other site 592029004911 GTP/Mg2+ binding site [chemical binding]; other site 592029004912 Switch I region; other site 592029004913 G2 box; other site 592029004914 G3 box; other site 592029004915 Switch II region; other site 592029004916 G4 box; other site 592029004917 G5 box; other site 592029004918 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 592029004919 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 592029004920 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 592029004921 FtsX-like permease family; Region: FtsX; pfam02687 592029004922 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 592029004923 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 592029004924 active site 592029004925 substrate binding site [chemical binding]; other site 592029004926 Mg2+ binding site [ion binding]; other site 592029004927 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592029004928 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 592029004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592029004930 dimer interface [polypeptide binding]; other site 592029004931 conserved gate region; other site 592029004932 putative PBP binding loops; other site 592029004933 ABC-ATPase subunit interface; other site 592029004934 C-terminal peptidase (prc); Region: prc; TIGR00225 592029004935 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592029004936 protein binding site [polypeptide binding]; other site 592029004937 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 592029004938 Catalytic dyad [active] 592029004939 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 592029004940 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 592029004941 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 592029004942 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 592029004943 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592029004944 NlpC/P60 family; Region: NLPC_P60; pfam00877 592029004945 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 592029004946 Competence protein; Region: Competence; pfam03772 592029004947 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 592029004948 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 592029004949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029004950 POT family; Region: PTR2; cl17359 592029004951 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 592029004952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029004953 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029004954 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 592029004955 homodimer interface [polypeptide binding]; other site 592029004956 catalytic residues [active] 592029004957 NAD binding site [chemical binding]; other site 592029004958 substrate binding pocket [chemical binding]; other site 592029004959 flexible flap; other site 592029004960 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 592029004961 Predicted membrane protein [Function unknown]; Region: COG2259 592029004962 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029004963 catalytic residues [active] 592029004964 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 592029004965 phosphoglyceromutase; Provisional; Region: PRK05434 592029004966 flavoprotein, HI0933 family; Region: TIGR00275 592029004967 Transposase IS200 like; Region: Y1_Tnp; cl00848 592029004968 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 592029004969 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 592029004970 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592029004971 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 592029004972 NAD binding site [chemical binding]; other site 592029004973 catalytic residues [active] 592029004974 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 592029004975 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 592029004976 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 592029004977 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029004978 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 592029004979 ApbE family; Region: ApbE; pfam02424 592029004980 Transposase IS200 like; Region: Y1_Tnp; pfam01797 592029004981 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029004982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029004983 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592029004984 active site 592029004985 short chain dehydrogenase; Provisional; Region: PRK08339 592029004986 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 592029004987 putative NAD(P) binding site [chemical binding]; other site 592029004988 putative active site [active] 592029004989 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592029004990 Leucine rich repeat; Region: LRR_8; pfam13855 592029004991 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592029004992 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592029004993 dimer interface [polypeptide binding]; other site 592029004994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029004995 catalytic residue [active] 592029004996 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 592029004997 PspC domain; Region: PspC; cl00864 592029004998 Ion channel; Region: Ion_trans_2; pfam07885 592029004999 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 592029005000 TrkA-N domain; Region: TrkA_N; pfam02254 592029005001 TrkA-C domain; Region: TrkA_C; pfam02080 592029005002 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 592029005003 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 592029005004 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 592029005005 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 592029005006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592029005007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592029005008 active site 592029005009 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 592029005010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592029005011 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 592029005012 active site 592029005013 DNA binding site [nucleotide binding] 592029005014 Int/Topo IB signature motif; other site 592029005015 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 592029005016 30S subunit binding site; other site 592029005017 elongation factor Tu; Reviewed; Region: PRK12735 592029005018 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 592029005019 G1 box; other site 592029005020 GEF interaction site [polypeptide binding]; other site 592029005021 GTP/Mg2+ binding site [chemical binding]; other site 592029005022 Switch I region; other site 592029005023 G2 box; other site 592029005024 G3 box; other site 592029005025 Switch II region; other site 592029005026 G4 box; other site 592029005027 G5 box; other site 592029005028 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 592029005029 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 592029005030 Antibiotic Binding Site [chemical binding]; other site 592029005031 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 592029005032 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 592029005033 putative homodimer interface [polypeptide binding]; other site 592029005034 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 592029005035 heterodimer interface [polypeptide binding]; other site 592029005036 homodimer interface [polypeptide binding]; other site 592029005037 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 592029005038 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 592029005039 23S rRNA interface [nucleotide binding]; other site 592029005040 L7/L12 interface [polypeptide binding]; other site 592029005041 putative thiostrepton binding site; other site 592029005042 L25 interface [polypeptide binding]; other site 592029005043 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 592029005044 mRNA/rRNA interface [nucleotide binding]; other site 592029005045 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 592029005046 23S rRNA interface [nucleotide binding]; other site 592029005047 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 592029005048 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 592029005049 core dimer interface [polypeptide binding]; other site 592029005050 peripheral dimer interface [polypeptide binding]; other site 592029005051 L10 interface [polypeptide binding]; other site 592029005052 L11 interface [polypeptide binding]; other site 592029005053 putative EF-Tu interaction site [polypeptide binding]; other site 592029005054 putative EF-G interaction site [polypeptide binding]; other site 592029005055 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 592029005056 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 592029005057 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 592029005058 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592029005059 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 592029005060 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592029005061 RPB3 interaction site [polypeptide binding]; other site 592029005062 RPB1 interaction site [polypeptide binding]; other site 592029005063 RPB11 interaction site [polypeptide binding]; other site 592029005064 RPB10 interaction site [polypeptide binding]; other site 592029005065 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 592029005066 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 592029005067 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 592029005068 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 592029005069 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 592029005070 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 592029005071 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 592029005072 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 592029005073 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 592029005074 DNA binding site [nucleotide binding] 592029005075 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 592029005076 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 592029005077 Calx-beta domain; Region: Calx-beta; cl02522 592029005078 Calx-beta domain; Region: Calx-beta; cl02522 592029005079 Calx-beta domain; Region: Calx-beta; cl02522 592029005080 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 592029005081 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 592029005082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029005083 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029005084 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 592029005085 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029005086 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029005087 ligand binding site [chemical binding]; other site 592029005088 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 592029005089 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 592029005090 G1 box; other site 592029005091 putative GEF interaction site [polypeptide binding]; other site 592029005092 GTP/Mg2+ binding site [chemical binding]; other site 592029005093 Switch I region; other site 592029005094 G2 box; other site 592029005095 G3 box; other site 592029005096 Switch II region; other site 592029005097 G4 box; other site 592029005098 G5 box; other site 592029005099 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 592029005100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592029005101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592029005102 DNA binding site [nucleotide binding] 592029005103 domain linker motif; other site 592029005104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592029005105 dimerization interface [polypeptide binding]; other site 592029005106 ligand binding site [chemical binding]; other site 592029005107 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 592029005108 active site 592029005109 metal binding site [ion binding]; metal-binding site 592029005110 nudix motif; other site 592029005111 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592029005112 active site 592029005113 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 592029005114 Protein of unknown function (DUF819); Region: DUF819; cl02317 592029005115 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029005116 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 592029005117 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 592029005118 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 592029005119 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592029005120 dimer interface [polypeptide binding]; other site 592029005121 active site 592029005122 CoA binding pocket [chemical binding]; other site 592029005123 Transposase IS200 like; Region: Y1_Tnp; pfam01797 592029005124 CoA binding domain; Region: CoA_binding_2; pfam13380 592029005125 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 592029005126 Na binding site [ion binding]; other site 592029005127 Haemolytic domain; Region: Haemolytic; pfam01809 592029005128 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 592029005129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029005130 active site 592029005131 HIGH motif; other site 592029005132 nucleotide binding site [chemical binding]; other site 592029005133 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592029005134 KMSKS motif; other site 592029005135 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 592029005136 tRNA binding surface [nucleotide binding]; other site 592029005137 anticodon binding site; other site 592029005138 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 592029005139 GTP cyclohydrolase I; Provisional; Region: PLN03044 592029005140 active site 592029005141 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 592029005142 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 592029005143 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 592029005144 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029005145 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 592029005146 prolyl-tRNA synthetase; Provisional; Region: PRK08661 592029005147 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 592029005148 dimer interface [polypeptide binding]; other site 592029005149 motif 1; other site 592029005150 active site 592029005151 motif 2; other site 592029005152 motif 3; other site 592029005153 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 592029005154 anticodon binding site; other site 592029005155 zinc-binding site [ion binding]; other site 592029005156 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 592029005157 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 592029005158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029005159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029005160 DNA binding residues [nucleotide binding] 592029005161 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 592029005162 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 592029005163 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 592029005164 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592029005165 active site 592029005166 HIGH motif; other site 592029005167 nucleotide binding site [chemical binding]; other site 592029005168 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 592029005169 KMSK motif region; other site 592029005170 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 592029005171 tRNA binding surface [nucleotide binding]; other site 592029005172 anticodon binding site; other site 592029005173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029005174 binding surface 592029005175 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029005176 TPR motif; other site 592029005177 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029005178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029005179 TPR motif; other site 592029005180 binding surface 592029005181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029005182 binding surface 592029005183 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029005184 TPR motif; other site 592029005185 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592029005186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029005187 ATP binding site [chemical binding]; other site 592029005188 Walker A motif; other site 592029005189 Walker B motif; other site 592029005190 arginine finger; other site 592029005191 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 592029005192 active site pocket [active] 592029005193 oxyanion hole [active] 592029005194 catalytic triad [active] 592029005195 active site nucleophile [active] 592029005196 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 592029005197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029005198 S-adenosylmethionine binding site [chemical binding]; other site 592029005199 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 592029005200 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592029005201 ATP binding site [chemical binding]; other site 592029005202 Mg++ binding site [ion binding]; other site 592029005203 motif III; other site 592029005204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029005205 nucleotide binding region [chemical binding]; other site 592029005206 ATP-binding site [chemical binding]; other site 592029005207 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029005208 periplasmic chaperone; Provisional; Region: PRK10780 592029005209 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 592029005210 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592029005211 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592029005212 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592029005213 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 592029005214 active site clefts [active] 592029005215 zinc binding site [ion binding]; other site 592029005216 dimer interface [polypeptide binding]; other site 592029005217 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 592029005218 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 592029005219 active site 592029005220 nucleophile elbow; other site 592029005221 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 592029005222 TraB family; Region: TraB; pfam01963 592029005223 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592029005224 metal-binding site [ion binding] 592029005225 Predicted permease; Region: DUF318; cl17795 592029005226 Heavy-metal-associated domain; Region: HMA; pfam00403 592029005227 metal-binding site [ion binding] 592029005228 Heavy-metal-associated domain; Region: HMA; pfam00403 592029005229 metal-binding site [ion binding] 592029005230 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 592029005231 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029005232 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029005233 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 592029005234 Peptidase family M23; Region: Peptidase_M23; pfam01551 592029005235 Cell division protein ZapA; Region: ZapA; pfam05164 592029005236 phosphodiesterase; Provisional; Region: PRK12704 592029005237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029005238 Zn2+ binding site [ion binding]; other site 592029005239 Mg2+ binding site [ion binding]; other site 592029005240 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592029005242 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592029005243 active site 592029005244 catalytic tetrad [active] 592029005245 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 592029005246 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 592029005247 active site 592029005248 Int/Topo IB signature motif; other site 592029005249 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029005250 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029005251 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 592029005252 Dehydroquinase class II; Region: DHquinase_II; pfam01220 592029005253 active site 592029005254 trimer interface [polypeptide binding]; other site 592029005255 dimer interface [polypeptide binding]; other site 592029005256 TM2 domain; Region: TM2; pfam05154 592029005257 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029005258 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029005259 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 592029005260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029005261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029005262 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592029005263 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 592029005264 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 592029005265 quinone interaction residues [chemical binding]; other site 592029005266 active site 592029005267 catalytic residues [active] 592029005268 FMN binding site [chemical binding]; other site 592029005269 substrate binding site [chemical binding]; other site 592029005270 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592029005271 PemK-like protein; Region: PemK; pfam02452 592029005272 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 592029005273 active site 592029005274 catalytic residues [active] 592029005275 metal binding site [ion binding]; metal-binding site 592029005276 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 592029005277 catalytic site [active] 592029005278 metal binding site [ion binding]; metal-binding site 592029005279 GH3 auxin-responsive promoter; Region: GH3; pfam03321 592029005280 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 592029005281 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 592029005282 FAD binding pocket [chemical binding]; other site 592029005283 FAD binding motif [chemical binding]; other site 592029005284 phosphate binding motif [ion binding]; other site 592029005285 beta-alpha-beta structure motif; other site 592029005286 NAD(p) ribose binding residues [chemical binding]; other site 592029005287 NAD binding pocket [chemical binding]; other site 592029005288 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 592029005289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592029005290 catalytic loop [active] 592029005291 iron binding site [ion binding]; other site 592029005292 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 592029005293 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 592029005294 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 592029005295 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 592029005296 four helix bundle protein; Region: TIGR02436 592029005297 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 592029005298 four helix bundle protein; Region: TIGR02436 592029005299 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 592029005300 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 592029005301 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 592029005302 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005303 enoyl-CoA hydratase; Provisional; Region: PRK08140 592029005304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592029005305 substrate binding site [chemical binding]; other site 592029005306 oxyanion hole (OAH) forming residues; other site 592029005307 trimer interface [polypeptide binding]; other site 592029005308 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592029005309 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592029005310 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 592029005311 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 592029005312 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592029005313 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592029005314 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592029005315 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 592029005316 four helix bundle protein; Region: TIGR02436 592029005317 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 592029005318 CoenzymeA binding site [chemical binding]; other site 592029005319 subunit interaction site [polypeptide binding]; other site 592029005320 PHB binding site; other site 592029005321 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005322 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 592029005323 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592029005324 dimer interface [polypeptide binding]; other site 592029005325 active site 592029005326 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005327 Immunoglobulin domain; Region: Ig; cl11960 592029005328 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 592029005329 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 592029005330 substrate binding site [chemical binding]; other site 592029005331 dimer interface [polypeptide binding]; other site 592029005332 NADP binding site [chemical binding]; other site 592029005333 catalytic residues [active] 592029005334 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 592029005335 active site 2 [active] 592029005336 active site 1 [active] 592029005337 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 592029005338 GIY-YIG motif/motif A; other site 592029005339 putative active site [active] 592029005340 putative metal binding site [ion binding]; other site 592029005341 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 592029005342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592029005343 substrate binding site [chemical binding]; other site 592029005344 oxyanion hole (OAH) forming residues; other site 592029005345 trimer interface [polypeptide binding]; other site 592029005346 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 592029005347 active site 592029005348 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 592029005349 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 592029005350 putative trimer interface [polypeptide binding]; other site 592029005351 putative metal binding site [ion binding]; other site 592029005352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592029005353 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 592029005354 E3 interaction surface; other site 592029005355 lipoyl attachment site [posttranslational modification]; other site 592029005356 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592029005357 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 592029005358 GIY-YIG motif/motif A; other site 592029005359 putative active site [active] 592029005360 putative metal binding site [ion binding]; other site 592029005361 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 592029005362 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592029005363 tetramer interface [polypeptide binding]; other site 592029005364 TPP-binding site [chemical binding]; other site 592029005365 heterodimer interface [polypeptide binding]; other site 592029005366 phosphorylation loop region [posttranslational modification] 592029005367 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 592029005368 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592029005369 alpha subunit interface [polypeptide binding]; other site 592029005370 TPP binding site [chemical binding]; other site 592029005371 heterodimer interface [polypeptide binding]; other site 592029005372 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592029005373 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 592029005374 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 592029005375 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 592029005376 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 592029005377 urocanate hydratase; Provisional; Region: PRK05414 592029005378 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 592029005379 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 592029005380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029005381 catalytic residue [active] 592029005382 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 592029005383 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592029005384 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029005385 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 592029005386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592029005387 inhibitor-cofactor binding pocket; inhibition site 592029005388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029005389 catalytic residue [active] 592029005390 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029005391 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029005392 catalytic residues [active] 592029005393 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 592029005394 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 592029005395 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 592029005396 dimer interface [polypeptide binding]; other site 592029005397 putative anticodon binding site; other site 592029005398 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 592029005399 motif 1; other site 592029005400 active site 592029005401 motif 2; other site 592029005402 motif 3; other site 592029005403 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 592029005404 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 592029005405 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 592029005406 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029005407 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 592029005408 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 592029005409 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592029005410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029005411 S-adenosylmethionine binding site [chemical binding]; other site 592029005412 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 592029005413 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 592029005414 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 592029005415 DNA photolyase; Region: DNA_photolyase; pfam00875 592029005416 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 592029005417 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 592029005418 Putative coat protein; Region: YlbD_coat; pfam14071 592029005419 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592029005420 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592029005421 ligand binding site [chemical binding]; other site 592029005422 flexible hinge region; other site 592029005423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029005424 ATP binding site [chemical binding]; other site 592029005425 Mg2+ binding site [ion binding]; other site 592029005426 G-X-G motif; other site 592029005427 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592029005428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029005429 active site 592029005430 phosphorylation site [posttranslational modification] 592029005431 intermolecular recognition site; other site 592029005432 dimerization interface [polypeptide binding]; other site 592029005433 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 592029005434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592029005435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029005436 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029005437 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 592029005438 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029005439 Coatomer WD associated region; Region: Coatomer_WDAD; pfam04053 592029005440 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 592029005441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029005442 TPR motif; other site 592029005443 binding surface 592029005444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029005445 binding surface 592029005446 TPR repeat; Region: TPR_11; pfam13414 592029005447 TPR motif; other site 592029005448 TPR repeat; Region: TPR_11; pfam13414 592029005449 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 592029005450 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 592029005451 RNA/DNA hybrid binding site [nucleotide binding]; other site 592029005452 active site 592029005453 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 592029005454 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 592029005455 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 592029005456 active site 592029005457 DNA binding site [nucleotide binding] 592029005458 Int/Topo IB signature motif; other site 592029005459 catalytic residues [active] 592029005460 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 592029005461 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592029005462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 592029005463 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 592029005464 active site 592029005465 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592029005466 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592029005467 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 592029005468 competence damage-inducible protein A; Provisional; Region: PRK00549 592029005469 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 592029005470 putative MPT binding site; other site 592029005471 Competence-damaged protein; Region: CinA; pfam02464 592029005472 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 592029005473 ribosomal protein L33; Region: rpl33; CHL00104 592029005474 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 592029005475 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 592029005476 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 592029005477 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592029005478 amidase; Provisional; Region: PRK06828 592029005479 Amidase; Region: Amidase; cl11426 592029005480 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 592029005481 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029005482 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029005483 VanW like protein; Region: VanW; pfam04294 592029005484 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592029005485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029005486 S-adenosylmethionine binding site [chemical binding]; other site 592029005487 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 592029005488 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592029005489 TRAM domain; Region: TRAM; cl01282 592029005490 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592029005491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029005492 Walker A/P-loop; other site 592029005493 ATP binding site [chemical binding]; other site 592029005494 Q-loop/lid; other site 592029005495 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029005496 ABC transporter signature motif; other site 592029005497 Walker B; other site 592029005498 D-loop; other site 592029005499 ABC transporter; Region: ABC_tran_2; pfam12848 592029005500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029005501 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 592029005502 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 592029005503 active site 592029005504 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 592029005505 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 592029005506 ligand-binding site [chemical binding]; other site 592029005507 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 592029005508 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 592029005509 Active Sites [active] 592029005510 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 592029005511 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 592029005512 CysD dimerization site [polypeptide binding]; other site 592029005513 G1 box; other site 592029005514 putative GEF interaction site [polypeptide binding]; other site 592029005515 GTP/Mg2+ binding site [chemical binding]; other site 592029005516 Switch I region; other site 592029005517 G2 box; other site 592029005518 G3 box; other site 592029005519 Switch II region; other site 592029005520 G4 box; other site 592029005521 G5 box; other site 592029005522 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 592029005523 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 592029005524 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 592029005525 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 592029005526 Chain length determinant protein; Region: Wzz; cl15801 592029005527 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 592029005528 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592029005529 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 592029005530 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 592029005531 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 592029005532 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 592029005533 Walker A/P-loop; other site 592029005534 ATP binding site [chemical binding]; other site 592029005535 Q-loop/lid; other site 592029005536 ABC transporter signature motif; other site 592029005537 Walker B; other site 592029005538 D-loop; other site 592029005539 H-loop/switch region; other site 592029005540 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 592029005541 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 592029005542 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005543 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 592029005544 active site 592029005545 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 592029005546 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029005548 active site 592029005549 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 592029005550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005551 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 592029005552 metal-binding site 592029005553 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 592029005554 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005555 metal-binding site 592029005556 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 592029005557 metal-binding site 592029005558 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029005560 active site 592029005561 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029005563 active site 592029005564 putative glycosyl transferase; Provisional; Region: PRK10073 592029005565 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029005566 active site 592029005567 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 592029005568 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 592029005569 active site 592029005570 homodimer interface [polypeptide binding]; other site 592029005571 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029005573 active site 592029005574 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592029005575 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029005576 active site 592029005577 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029005578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029005579 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 592029005580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029005581 active site 592029005582 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 592029005583 ligand binding site; other site 592029005584 tetramer interface; other site 592029005585 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592029005586 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 592029005587 NeuB family; Region: NeuB; pfam03102 592029005588 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 592029005589 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 592029005590 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592029005591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029005592 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 592029005593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029005594 active site 592029005595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592029005596 active site 592029005597 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 592029005598 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029005599 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 592029005600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029005601 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 592029005602 putative ADP-binding pocket [chemical binding]; other site 592029005603 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592029005604 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 592029005605 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 592029005606 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 592029005607 putative active site [active] 592029005608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 592029005609 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 592029005610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029005611 ATP binding site [chemical binding]; other site 592029005612 putative Mg++ binding site [ion binding]; other site 592029005613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029005614 nucleotide binding region [chemical binding]; other site 592029005615 ATP-binding site [chemical binding]; other site 592029005616 RQC domain; Region: RQC; pfam09382 592029005617 HRDC domain; Region: HRDC; pfam00570 592029005618 YceI-like domain; Region: YceI; smart00867 592029005619 MarR family; Region: MarR; pfam01047 592029005620 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029005621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 592029005622 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 592029005623 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592029005624 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 592029005625 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592029005626 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592029005627 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592029005628 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 592029005629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029005630 TIGR01777 family protein; Region: yfcH 592029005631 NAD(P) binding site [chemical binding]; other site 592029005632 active site 592029005633 KWG Leptospira; Region: KWG; pfam07656 592029005634 YceI-like domain; Region: YceI; pfam04264 592029005635 GrpE; Region: GrpE; pfam01025 592029005636 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 592029005637 dimer interface [polypeptide binding]; other site 592029005638 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 592029005639 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 592029005640 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592029005641 HSP70 interaction site [polypeptide binding]; other site 592029005642 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 592029005643 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 592029005644 dimer interface [polypeptide binding]; other site 592029005645 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 592029005646 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 592029005647 Walker A/P-loop; other site 592029005648 ATP binding site [chemical binding]; other site 592029005649 Q-loop/lid; other site 592029005650 ABC transporter signature motif; other site 592029005651 Walker B; other site 592029005652 D-loop; other site 592029005653 H-loop/switch region; other site 592029005654 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 592029005655 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 592029005656 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029005657 Response regulator receiver domain; Region: Response_reg; pfam00072 592029005658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029005659 active site 592029005660 phosphorylation site [posttranslational modification] 592029005661 intermolecular recognition site; other site 592029005662 dimerization interface [polypeptide binding]; other site 592029005663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029005664 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592029005665 Walker A motif; other site 592029005666 ATP binding site [chemical binding]; other site 592029005667 Walker B motif; other site 592029005668 arginine finger; other site 592029005669 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 592029005670 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592029005671 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 592029005672 PA/protease or protease-like domain interface [polypeptide binding]; other site 592029005673 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 592029005674 Peptidase family M28; Region: Peptidase_M28; pfam04389 592029005675 metal binding site [ion binding]; metal-binding site 592029005676 multidrug efflux protein; Reviewed; Region: PRK01766 592029005677 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 592029005678 cation binding site [ion binding]; other site 592029005679 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 592029005680 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 592029005681 dimer interface [polypeptide binding]; other site 592029005682 active site 592029005683 glycine-pyridoxal phosphate binding site [chemical binding]; other site 592029005684 folate binding site [chemical binding]; other site 592029005685 fumarylacetoacetase; Region: PLN02856 592029005686 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 592029005687 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592029005688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 592029005689 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 592029005690 GMP synthase; Reviewed; Region: guaA; PRK00074 592029005691 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 592029005692 AMP/PPi binding site [chemical binding]; other site 592029005693 candidate oxyanion hole; other site 592029005694 catalytic triad [active] 592029005695 potential glutamine specificity residues [chemical binding]; other site 592029005696 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 592029005697 ATP Binding subdomain [chemical binding]; other site 592029005698 Ligand Binding sites [chemical binding]; other site 592029005699 Dimerization subdomain; other site 592029005700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029005701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029005702 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592029005703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029005704 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 592029005705 ligand binding site [chemical binding]; other site 592029005706 OsmC-like protein; Region: OsmC; pfam02566 592029005707 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 592029005708 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 592029005709 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 592029005710 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005711 CTP synthetase; Validated; Region: pyrG; PRK05380 592029005712 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 592029005713 Catalytic site [active] 592029005714 active site 592029005715 UTP binding site [chemical binding]; other site 592029005716 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 592029005717 active site 592029005718 putative oxyanion hole; other site 592029005719 catalytic triad [active] 592029005720 membrane protein insertase; Provisional; Region: PRK01318 592029005721 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 592029005722 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 592029005723 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 592029005724 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592029005725 inhibitor-cofactor binding pocket; inhibition site 592029005726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029005727 catalytic residue [active] 592029005728 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592029005729 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 592029005730 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 592029005731 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592029005732 active site 592029005733 catalytic site [active] 592029005734 substrate binding site [chemical binding]; other site 592029005735 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 592029005736 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 592029005737 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 592029005738 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 592029005739 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 592029005740 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 592029005741 active site 592029005742 catalytic residues [active] 592029005743 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 592029005744 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 592029005745 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 592029005746 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 592029005747 MFS/sugar transport protein; Region: MFS_2; pfam13347 592029005748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029005749 putative substrate translocation pore; other site 592029005750 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 592029005751 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 592029005752 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 592029005753 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 592029005754 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 592029005755 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 592029005756 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005757 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592029005758 FAD binding domain; Region: FAD_binding_4; pfam01565 592029005759 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592029005760 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592029005761 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 592029005762 Terminase-like family; Region: Terminase_6; pfam03237 592029005763 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 592029005764 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592029005765 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592029005766 MoxR-like ATPases [General function prediction only]; Region: COG0714 592029005767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029005768 Walker A motif; other site 592029005769 ATP binding site [chemical binding]; other site 592029005770 Walker B motif; other site 592029005771 arginine finger; other site 592029005772 aconitate hydratase; Validated; Region: PRK07229 592029005773 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 592029005774 substrate binding site [chemical binding]; other site 592029005775 ligand binding site [chemical binding]; other site 592029005776 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 592029005777 substrate binding site [chemical binding]; other site 592029005778 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 592029005779 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 592029005780 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005781 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 592029005782 Inward rectifier potassium channel; Region: IRK; pfam01007 592029005783 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 592029005784 lycopene cyclase; Region: lycopene_cycl; TIGR01789 592029005785 Protein of unknown function (DUF422); Region: DUF422; cl00991 592029005786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592029005787 phytoene desaturase; Region: crtI_fam; TIGR02734 592029005788 beta-carotene hydroxylase; Region: PLN02601 592029005789 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 592029005790 active site lid residues [active] 592029005791 substrate binding pocket [chemical binding]; other site 592029005792 catalytic residues [active] 592029005793 substrate-Mg2+ binding site; other site 592029005794 aspartate-rich region 1; other site 592029005795 aspartate-rich region 2; other site 592029005796 phytoene desaturase; Region: crtI_fam; TIGR02734 592029005797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592029005798 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592029005799 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 592029005800 DNA binding residues [nucleotide binding] 592029005801 B12 binding domain; Region: B12-binding_2; pfam02607 592029005802 shikimate kinase; Reviewed; Region: aroK; PRK00131 592029005803 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 592029005804 ADP binding site [chemical binding]; other site 592029005805 magnesium binding site [ion binding]; other site 592029005806 putative shikimate binding site; other site 592029005807 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 592029005808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029005809 active site 592029005810 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 592029005811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029005812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592029005813 RNA binding surface [nucleotide binding]; other site 592029005814 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 592029005815 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592029005816 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592029005817 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592029005818 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 592029005819 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 592029005820 FG-GAP repeat; Region: FG-GAP_2; pfam14312 592029005821 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029005823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029005824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029005825 active site 592029005826 phosphorylation site [posttranslational modification] 592029005827 intermolecular recognition site; other site 592029005828 dimerization interface [polypeptide binding]; other site 592029005829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029005830 DNA binding residues [nucleotide binding] 592029005831 dimerization interface [polypeptide binding]; other site 592029005832 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592029005833 PGAP1-like protein; Region: PGAP1; pfam07819 592029005834 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 592029005835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 592029005836 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592029005837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029005838 Walker A/P-loop; other site 592029005839 ATP binding site [chemical binding]; other site 592029005840 Q-loop/lid; other site 592029005841 ABC transporter signature motif; other site 592029005842 Walker B; other site 592029005843 D-loop; other site 592029005844 H-loop/switch region; other site 592029005845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029005846 S-adenosylmethionine binding site [chemical binding]; other site 592029005847 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029005848 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029005849 catalytic residues [active] 592029005850 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 592029005851 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 592029005852 homodimer interface [polypeptide binding]; other site 592029005853 metal binding site [ion binding]; metal-binding site 592029005854 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 592029005855 homodimer interface [polypeptide binding]; other site 592029005856 active site 592029005857 putative chemical substrate binding site [chemical binding]; other site 592029005858 metal binding site [ion binding]; metal-binding site 592029005859 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 592029005860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029005861 S-adenosylmethionine binding site [chemical binding]; other site 592029005862 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 592029005863 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 592029005864 adenylosuccinate lyase; Provisional; Region: PRK09285 592029005865 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 592029005866 tetramer interface [polypeptide binding]; other site 592029005867 active site 592029005868 NAD-dependent deacetylase; Provisional; Region: PRK00481 592029005869 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 592029005870 NAD+ binding site [chemical binding]; other site 592029005871 substrate binding site [chemical binding]; other site 592029005872 Zn binding site [ion binding]; other site 592029005873 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 592029005874 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 592029005875 putative tRNA-binding site [nucleotide binding]; other site 592029005876 B3/4 domain; Region: B3_4; pfam03483 592029005877 tRNA synthetase B5 domain; Region: B5; pfam03484 592029005878 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 592029005879 dimer interface [polypeptide binding]; other site 592029005880 motif 1; other site 592029005881 motif 3; other site 592029005882 motif 2; other site 592029005883 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 592029005884 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 592029005885 homopentamer interface [polypeptide binding]; other site 592029005886 active site 592029005887 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 592029005888 recombination protein F; Reviewed; Region: recF; PRK00064 592029005889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029005890 Walker A/P-loop; other site 592029005891 ATP binding site [chemical binding]; other site 592029005892 Q-loop/lid; other site 592029005893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029005894 ABC transporter signature motif; other site 592029005895 Walker B; other site 592029005896 D-loop; other site 592029005897 H-loop/switch region; other site 592029005898 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 592029005899 Protein of unknown function (DUF721); Region: DUF721; pfam05258 592029005900 Family of unknown function (DUF490); Region: DUF490; pfam04357 592029005901 Family of unknown function (DUF490); Region: DUF490; pfam04357 592029005902 UGMP family protein; Validated; Region: PRK09604 592029005903 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 592029005904 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 592029005905 RNA methyltransferase, RsmE family; Region: TIGR00046 592029005906 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 592029005907 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 592029005908 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592029005909 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 592029005910 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592029005911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029005912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029005913 ABC transporter; Region: ABC_tran_2; pfam12848 592029005914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029005915 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 592029005916 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592029005917 putative acyl-acceptor binding pocket; other site 592029005918 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 592029005919 putative active site [active] 592029005920 putative CoA binding site [chemical binding]; other site 592029005921 nudix motif; other site 592029005922 metal binding site [ion binding]; metal-binding site 592029005923 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 592029005924 active site 592029005925 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 592029005926 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592029005927 dimer interface [polypeptide binding]; other site 592029005928 active site 592029005929 CoA binding pocket [chemical binding]; other site 592029005930 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 592029005931 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 592029005932 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 592029005933 active site 592029005934 catalytic triad [active] 592029005935 oxyanion hole [active] 592029005936 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 592029005937 Protein export membrane protein; Region: SecD_SecF; cl14618 592029005938 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 592029005939 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 592029005940 DXD motif; other site 592029005941 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 592029005942 Asp-box motif; other site 592029005943 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029005944 glycine dehydrogenase; Provisional; Region: PRK05367 592029005945 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 592029005946 tetramer interface [polypeptide binding]; other site 592029005947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029005948 catalytic residue [active] 592029005949 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 592029005950 tetramer interface [polypeptide binding]; other site 592029005951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029005952 catalytic residue [active] 592029005953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029005954 RNA polymerase sigma factor; Provisional; Region: PRK12520 592029005955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029005956 DNA binding residues [nucleotide binding] 592029005957 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 592029005958 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 592029005959 active site 592029005960 Zn binding site [ion binding]; other site 592029005961 AIR carboxylase; Region: AIRC; pfam00731 592029005962 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 592029005963 SelR domain; Region: SelR; pfam01641 592029005964 methionine sulfoxide reductase B; Provisional; Region: PRK00222 592029005965 SelR domain; Region: SelR; pfam01641 592029005966 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592029005967 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592029005968 ATP binding site [chemical binding]; other site 592029005969 Mg++ binding site [ion binding]; other site 592029005970 motif III; other site 592029005971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029005972 nucleotide binding region [chemical binding]; other site 592029005973 ATP-binding site [chemical binding]; other site 592029005974 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029005975 ligand binding site [chemical binding]; other site 592029005976 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029005977 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029005978 ligand binding site [chemical binding]; other site 592029005979 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 592029005980 active site 592029005981 DNA binding site [nucleotide binding] 592029005982 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 592029005983 classical (c) SDRs; Region: SDR_c; cd05233 592029005984 NAD(P) binding site [chemical binding]; other site 592029005985 active site 592029005986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029005987 S-adenosylmethionine binding site [chemical binding]; other site 592029005988 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029005989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029005990 active site 592029005991 phosphorylation site [posttranslational modification] 592029005992 intermolecular recognition site; other site 592029005993 dimerization interface [polypeptide binding]; other site 592029005994 LytTr DNA-binding domain; Region: LytTR; pfam04397 592029005995 Histidine kinase; Region: His_kinase; pfam06580 592029005996 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 592029005997 Mg2+ binding site [ion binding]; other site 592029005998 G-X-G motif; other site 592029005999 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 592029006000 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 592029006001 heat shock protein 90; Provisional; Region: PRK05218 592029006002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006003 ATP binding site [chemical binding]; other site 592029006004 Mg2+ binding site [ion binding]; other site 592029006005 G-X-G motif; other site 592029006006 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592029006007 active site 592029006008 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 592029006009 short chain dehydrogenase; Provisional; Region: PRK06179 592029006010 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592029006011 NADP binding site [chemical binding]; other site 592029006012 active site 592029006013 steroid binding site; other site 592029006014 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 592029006015 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 592029006016 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 592029006017 active site 592029006018 catalytic site [active] 592029006019 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 592029006020 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 592029006021 BRO family, N-terminal domain; Region: Bro-N; smart01040 592029006022 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 592029006023 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 592029006024 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 592029006025 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 592029006026 putative active site [active] 592029006027 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 592029006028 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 592029006029 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 592029006030 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 592029006031 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 592029006032 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 592029006033 Hemerythrin-like domain; Region: Hr-like; cd12108 592029006034 Domain of unknown function (DUF1083); Region: DUF1083; pfam06452 592029006035 putative ligand binding site [chemical binding]; other site 592029006036 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592029006037 active site 592029006038 catalytic site [active] 592029006039 substrate binding site [chemical binding]; other site 592029006040 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 592029006041 GIY-YIG motif/motif A; other site 592029006042 active site 592029006043 catalytic site [active] 592029006044 putative DNA binding site [nucleotide binding]; other site 592029006045 metal binding site [ion binding]; metal-binding site 592029006046 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592029006047 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029006048 Walker A/P-loop; other site 592029006049 ATP binding site [chemical binding]; other site 592029006050 Q-loop/lid; other site 592029006051 ABC transporter signature motif; other site 592029006052 Walker B; other site 592029006053 D-loop; other site 592029006054 H-loop/switch region; other site 592029006055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006056 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 592029006057 FtsX-like permease family; Region: FtsX; pfam02687 592029006058 FtsX-like permease family; Region: FtsX; pfam02687 592029006059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006060 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029006061 FtsX-like permease family; Region: FtsX; pfam02687 592029006062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006063 FtsX-like permease family; Region: FtsX; pfam02687 592029006064 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006065 FtsX-like permease family; Region: FtsX; pfam02687 592029006066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006067 FtsX-like permease family; Region: FtsX; pfam02687 592029006068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006069 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 592029006070 FtsX-like permease family; Region: FtsX; pfam02687 592029006071 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 592029006072 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006073 FtsX-like permease family; Region: FtsX; pfam02687 592029006074 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006075 FtsX-like permease family; Region: FtsX; pfam02687 592029006076 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006077 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 592029006078 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006079 FtsX-like permease family; Region: FtsX; pfam02687 592029006080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592029006081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029006082 Walker A/P-loop; other site 592029006083 ATP binding site [chemical binding]; other site 592029006084 Q-loop/lid; other site 592029006085 ABC transporter signature motif; other site 592029006086 Walker B; other site 592029006087 D-loop; other site 592029006088 H-loop/switch region; other site 592029006089 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592029006090 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592029006091 HlyD family secretion protein; Region: HlyD_3; pfam13437 592029006092 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 592029006093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029006094 active site 592029006095 phosphorylation site [posttranslational modification] 592029006096 intermolecular recognition site; other site 592029006097 dimerization interface [polypeptide binding]; other site 592029006098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029006099 Walker A motif; other site 592029006100 ATP binding site [chemical binding]; other site 592029006101 Walker B motif; other site 592029006102 arginine finger; other site 592029006103 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592029006104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029006105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006106 ATP binding site [chemical binding]; other site 592029006107 G-X-G motif; other site 592029006108 hypothetical protein; Validated; Region: PRK00029 592029006109 Uncharacterized conserved protein [Function unknown]; Region: COG0397 592029006110 Domain of unknown function (DUF373); Region: DUF373; cl12079 592029006111 Methyltransferase domain; Region: Methyltransf_26; pfam13659 592029006112 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 592029006113 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 592029006114 GIY-YIG motif/motif A; other site 592029006115 putative active site [active] 592029006116 putative metal binding site [ion binding]; other site 592029006117 Domain of unknown function (DUF427); Region: DUF427; pfam04248 592029006118 hypothetical protein; Provisional; Region: PRK04233 592029006119 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 592029006120 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029006121 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592029006122 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 592029006123 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592029006124 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592029006125 protein binding site [polypeptide binding]; other site 592029006126 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 592029006127 Domain interface; other site 592029006128 Peptide binding site; other site 592029006129 Active site tetrad [active] 592029006130 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 592029006131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029006132 dimer interface [polypeptide binding]; other site 592029006133 phosphorylation site [posttranslational modification] 592029006134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006135 ATP binding site [chemical binding]; other site 592029006136 Mg2+ binding site [ion binding]; other site 592029006137 G-X-G motif; other site 592029006138 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592029006139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029006140 active site 592029006141 phosphorylation site [posttranslational modification] 592029006142 intermolecular recognition site; other site 592029006143 dimerization interface [polypeptide binding]; other site 592029006144 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 592029006145 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 592029006146 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 592029006147 GTP/Mg2+ binding site [chemical binding]; other site 592029006148 G4 box; other site 592029006149 G5 box; other site 592029006150 trmE is a tRNA modification GTPase; Region: trmE; cd04164 592029006151 G1 box; other site 592029006152 G1 box; other site 592029006153 GTP/Mg2+ binding site [chemical binding]; other site 592029006154 Switch I region; other site 592029006155 Switch I region; other site 592029006156 G2 box; other site 592029006157 G2 box; other site 592029006158 Switch II region; other site 592029006159 G3 box; other site 592029006160 G4 box; other site 592029006161 G5 box; other site 592029006162 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 592029006163 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 592029006164 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 592029006165 putative binding surface; other site 592029006166 active site 592029006167 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 592029006168 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 592029006169 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 592029006170 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 592029006171 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029006172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029006173 active site 592029006174 phosphorylation site [posttranslational modification] 592029006175 intermolecular recognition site; other site 592029006176 dimerization interface [polypeptide binding]; other site 592029006177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029006178 DNA binding residues [nucleotide binding] 592029006179 dimerization interface [polypeptide binding]; other site 592029006180 Histidine kinase; Region: HisKA_3; pfam07730 592029006181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006182 ATP binding site [chemical binding]; other site 592029006183 Mg2+ binding site [ion binding]; other site 592029006184 G-X-G motif; other site 592029006185 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 592029006186 FMN binding site [chemical binding]; other site 592029006187 dimer interface [polypeptide binding]; other site 592029006188 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 592029006189 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592029006190 ATP binding site [chemical binding]; other site 592029006191 Mg++ binding site [ion binding]; other site 592029006192 motif III; other site 592029006193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029006194 nucleotide binding region [chemical binding]; other site 592029006195 ATP-binding site [chemical binding]; other site 592029006196 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 592029006197 RNA binding site [nucleotide binding]; other site 592029006198 Calx-beta domain; Region: Calx-beta; cl02522 592029006199 Endonuclease I; Region: Endonuclease_1; pfam04231 592029006200 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006201 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 592029006202 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 592029006203 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 592029006204 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592029006205 NAD(P) binding site [chemical binding]; other site 592029006206 putative active site [active] 592029006207 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 592029006208 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 592029006209 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592029006210 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592029006211 Predicted transcriptional regulators [Transcription]; Region: COG1695 592029006212 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 592029006213 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592029006214 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592029006215 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 592029006216 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592029006217 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592029006218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592029006219 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592029006220 YceG-like family; Region: YceG; pfam02618 592029006221 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 592029006222 dimerization interface [polypeptide binding]; other site 592029006223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 592029006224 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592029006225 catalytic residue [active] 592029006226 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 592029006227 Uncharacterized conserved protein [Function unknown]; Region: COG4198 592029006228 Fic family protein [Function unknown]; Region: COG3177 592029006229 Fic/DOC family; Region: Fic; pfam02661 592029006230 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 592029006231 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592029006232 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592029006233 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029006234 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029006235 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592029006236 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592029006237 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 592029006238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029006239 S-adenosylmethionine binding site [chemical binding]; other site 592029006240 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 592029006241 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006242 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 592029006243 proposed catalytic triad [active] 592029006244 active site nucleophile [active] 592029006245 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 592029006246 active sites [active] 592029006247 tetramer interface [polypeptide binding]; other site 592029006248 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 592029006249 Clp amino terminal domain; Region: Clp_N; pfam02861 592029006250 Clp amino terminal domain; Region: Clp_N; pfam02861 592029006251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029006252 Walker A motif; other site 592029006253 ATP binding site [chemical binding]; other site 592029006254 Walker B motif; other site 592029006255 arginine finger; other site 592029006256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029006257 Walker A motif; other site 592029006258 ATP binding site [chemical binding]; other site 592029006259 Walker B motif; other site 592029006260 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 592029006261 DNA gyrase subunit A; Validated; Region: PRK05560 592029006262 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 592029006263 CAP-like domain; other site 592029006264 active site 592029006265 primary dimer interface [polypeptide binding]; other site 592029006266 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592029006267 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592029006268 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592029006269 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592029006270 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592029006271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592029006272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006273 binding surface 592029006274 TPR motif; other site 592029006275 TPR repeat; Region: TPR_11; pfam13414 592029006276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006277 binding surface 592029006278 TPR motif; other site 592029006279 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029006280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006281 binding surface 592029006282 TPR motif; other site 592029006283 TPR repeat; Region: TPR_11; pfam13414 592029006284 Bacterial SH3 domain; Region: SH3_3; cl17532 592029006285 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592029006286 NlpC/P60 family; Region: NLPC_P60; pfam00877 592029006287 acetyl-CoA C-acetyltransferase; Region: PLN02644 592029006288 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592029006289 dimer interface [polypeptide binding]; other site 592029006290 active site 592029006291 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 592029006292 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 592029006293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029006294 Zn2+ binding site [ion binding]; other site 592029006295 Mg2+ binding site [ion binding]; other site 592029006296 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 592029006297 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 592029006298 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 592029006299 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 592029006300 catalytic core [active] 592029006301 polyphosphate kinase; Provisional; Region: PRK05443 592029006302 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 592029006303 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 592029006304 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 592029006305 domain interface [polypeptide binding]; other site 592029006306 active site 592029006307 catalytic site [active] 592029006308 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 592029006309 domain interface [polypeptide binding]; other site 592029006310 active site 592029006311 catalytic site [active] 592029006312 exopolyphosphatase; Region: exo_poly_only; TIGR03706 592029006313 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 592029006314 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029006315 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 592029006316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029006317 Walker A motif; other site 592029006318 ATP binding site [chemical binding]; other site 592029006319 Walker B motif; other site 592029006320 arginine finger; other site 592029006321 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 592029006322 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592029006323 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592029006324 metal binding site [ion binding]; metal-binding site 592029006325 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 592029006326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029006327 S-adenosylmethionine binding site [chemical binding]; other site 592029006328 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 592029006329 AAA domain; Region: AAA_30; pfam13604 592029006330 Family description; Region: UvrD_C_2; pfam13538 592029006331 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 592029006332 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 592029006333 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 592029006334 active site 592029006335 catalytic site [active] 592029006336 substrate binding site [chemical binding]; other site 592029006337 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 592029006338 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 592029006339 Ligand binding site; other site 592029006340 oligomer interface; other site 592029006341 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029006342 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592029006343 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592029006344 catalytic residue [active] 592029006345 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 592029006346 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 592029006347 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 592029006348 putative active site [active] 592029006349 catalytic site [active] 592029006350 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 592029006351 putative active site [active] 592029006352 catalytic site [active] 592029006353 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592029006354 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 592029006355 TPR repeat; Region: TPR_11; pfam13414 592029006356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592029006357 binding surface 592029006358 TPR motif; other site 592029006359 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029006360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029006361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029006362 DNA binding residues [nucleotide binding] 592029006363 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029006364 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 592029006365 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 592029006366 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 592029006367 Na binding site [ion binding]; other site 592029006368 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 592029006369 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 592029006370 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 592029006371 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029006372 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029006373 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 592029006374 B12 binding site [chemical binding]; other site 592029006375 cobalt ligand [ion binding]; other site 592029006376 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 592029006377 Walker A; other site 592029006378 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 592029006379 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 592029006380 Leucine rich repeat; Region: LRR_8; pfam13855 592029006381 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006382 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006383 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006384 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 592029006385 putative catalytic site [active] 592029006386 putative metal binding site [ion binding]; other site 592029006387 putative phosphate binding site [ion binding]; other site 592029006388 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 592029006389 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 592029006390 putative hydrophobic ligand binding site [chemical binding]; other site 592029006391 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 592029006392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029006393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029006394 active site 592029006395 phosphorylation site [posttranslational modification] 592029006396 intermolecular recognition site; other site 592029006397 dimerization interface [polypeptide binding]; other site 592029006398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029006399 DNA binding residues [nucleotide binding] 592029006400 dimerization interface [polypeptide binding]; other site 592029006401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006402 binding surface 592029006403 TPR repeat; Region: TPR_11; pfam13414 592029006404 TPR motif; other site 592029006405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029006406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029006407 Histidine kinase; Region: HisKA_3; pfam07730 592029006408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006409 ATP binding site [chemical binding]; other site 592029006410 Mg2+ binding site [ion binding]; other site 592029006411 G-X-G motif; other site 592029006412 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 592029006413 Peptidase family M28; Region: Peptidase_M28; pfam04389 592029006414 putative metal binding site [ion binding]; other site 592029006415 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029006416 Interdomain contacts; other site 592029006417 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029006418 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029006419 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029006420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592029006421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 592029006422 active site 592029006423 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 592029006424 four helix bundle protein; Region: TIGR02436 592029006425 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 592029006426 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592029006427 dimer interface [polypeptide binding]; other site 592029006428 active site 592029006429 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 592029006430 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592029006431 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592029006432 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592029006433 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 592029006434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592029006435 substrate binding site [chemical binding]; other site 592029006436 oxyanion hole (OAH) forming residues; other site 592029006437 trimer interface [polypeptide binding]; other site 592029006438 MarR family; Region: MarR; pfam01047 592029006439 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 592029006440 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 592029006441 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 592029006442 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 592029006443 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029006444 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 592029006445 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 592029006446 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592029006447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029006448 Walker A/P-loop; other site 592029006449 ATP binding site [chemical binding]; other site 592029006450 Q-loop/lid; other site 592029006451 ABC transporter signature motif; other site 592029006452 Walker B; other site 592029006453 D-loop; other site 592029006454 H-loop/switch region; other site 592029006455 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 592029006456 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 592029006457 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 592029006458 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 592029006459 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 592029006460 active site 592029006461 dinuclear metal binding site [ion binding]; other site 592029006462 dimerization interface [polypeptide binding]; other site 592029006463 SnoaL-like domain; Region: SnoaL_2; pfam12680 592029006464 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029006465 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 592029006466 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592029006467 cytidylate kinase; Provisional; Region: cmk; PRK00023 592029006468 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 592029006469 CMP-binding site; other site 592029006470 The sites determining sugar specificity; other site 592029006471 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 592029006472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029006473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592029006474 putative substrate translocation pore; other site 592029006475 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 592029006476 Cytochrome c; Region: Cytochrom_C; cl11414 592029006477 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592029006478 Cytochrome c; Region: Cytochrom_C; pfam00034 592029006479 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029006480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029006481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029006482 DNA binding residues [nucleotide binding] 592029006483 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 592029006484 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 592029006485 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 592029006486 GTP-binding protein YchF; Reviewed; Region: PRK09601 592029006487 YchF GTPase; Region: YchF; cd01900 592029006488 G1 box; other site 592029006489 GTP/Mg2+ binding site [chemical binding]; other site 592029006490 Switch I region; other site 592029006491 G2 box; other site 592029006492 Switch II region; other site 592029006493 G3 box; other site 592029006494 G4 box; other site 592029006495 G5 box; other site 592029006496 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 592029006497 Putative addiction module component; Region: Unstab_antitox; cl09921 592029006498 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 592029006499 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 592029006500 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 592029006501 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 592029006502 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 592029006503 PhoH-like protein; Region: PhoH; pfam02562 592029006504 GLPGLI family protein; Region: GLPGLI; TIGR01200 592029006505 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029006506 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 592029006507 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 592029006508 DNA photolyase; Region: DNA_photolyase; pfam00875 592029006509 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 592029006510 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 592029006511 DNA photolyase; Region: DNA_photolyase; pfam00875 592029006512 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 592029006513 classical (c) SDRs; Region: SDR_c; cd05233 592029006514 NAD(P) binding site [chemical binding]; other site 592029006515 active site 592029006516 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 592029006517 putative hydrophobic ligand binding site [chemical binding]; other site 592029006518 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 592029006519 ligand binding site [chemical binding]; other site 592029006520 active site 592029006521 UGI interface [polypeptide binding]; other site 592029006522 catalytic site [active] 592029006523 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592029006524 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 592029006525 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592029006527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592029006528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029006529 Walker A/P-loop; other site 592029006530 ATP binding site [chemical binding]; other site 592029006531 Q-loop/lid; other site 592029006532 ABC transporter signature motif; other site 592029006533 Walker B; other site 592029006534 D-loop; other site 592029006535 H-loop/switch region; other site 592029006536 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592029006537 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592029006538 active site 592029006539 catalytic tetrad [active] 592029006540 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 592029006541 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 592029006542 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 592029006543 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 592029006544 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 592029006545 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 592029006546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029006547 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006548 PAAR motif; Region: PAAR_motif; pfam05488 592029006549 Phage protein D [General function prediction only]; Region: COG3500 592029006550 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 592029006551 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 592029006552 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 592029006553 active site 592029006554 metal binding site [ion binding]; metal-binding site 592029006555 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592029006556 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 592029006557 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 592029006558 nucleotide binding site [chemical binding]; other site 592029006559 NEF interaction site [polypeptide binding]; other site 592029006560 SBD interface [polypeptide binding]; other site 592029006561 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 592029006562 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 592029006563 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 592029006564 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029006565 Bacterial PH domain; Region: DUF304; cl01348 592029006566 Bacterial PH domain; Region: DUF304; pfam03703 592029006567 Bacterial PH domain; Region: DUF304; pfam03703 592029006568 Bacterial PH domain; Region: DUF304; pfam03703 592029006569 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 592029006570 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 592029006571 hexamer interface [polypeptide binding]; other site 592029006572 ligand binding site [chemical binding]; other site 592029006573 putative active site [active] 592029006574 NAD(P) binding site [chemical binding]; other site 592029006575 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 592029006576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029006577 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029006578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006579 TPR motif; other site 592029006580 binding surface 592029006581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006582 binding surface 592029006583 TPR motif; other site 592029006584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006585 binding surface 592029006586 TPR motif; other site 592029006587 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 592029006588 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592029006589 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 592029006590 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 592029006591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029006592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029006593 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 592029006594 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 592029006595 Predicted integral membrane protein [Function unknown]; Region: COG5617 592029006596 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 592029006597 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 592029006598 Ligand binding site; other site 592029006599 Ligand binding site; other site 592029006600 Ligand binding site; other site 592029006601 Putative Catalytic site; other site 592029006602 DXD motif; other site 592029006603 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 592029006604 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 592029006605 ZIP Zinc transporter; Region: Zip; pfam02535 592029006606 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 592029006607 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 592029006608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029006609 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029006610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029006611 S-adenosylmethionine binding site [chemical binding]; other site 592029006612 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 592029006613 active site 592029006614 dimer interface [polypeptide binding]; other site 592029006615 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 592029006616 peptide chain release factor 1; Validated; Region: prfA; PRK00591 592029006617 PCRF domain; Region: PCRF; pfam03462 592029006618 RF-1 domain; Region: RF-1; pfam00472 592029006619 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 592029006620 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 592029006621 putative active site [active] 592029006622 GIY-YIG motif/motif A; other site 592029006623 putative metal binding site [ion binding]; other site 592029006624 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 592029006625 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 592029006626 dimerization interface [polypeptide binding]; other site 592029006627 ATP binding site [chemical binding]; other site 592029006628 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 592029006629 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 592029006630 SusD family; Region: SusD; pfam07980 592029006631 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029006632 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 592029006633 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592029006634 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 592029006635 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006636 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 592029006637 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 592029006638 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592029006639 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 592029006640 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592029006641 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592029006642 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 592029006643 active site clefts [active] 592029006644 zinc binding site [ion binding]; other site 592029006645 dimer interface [polypeptide binding]; other site 592029006646 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 592029006647 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 592029006648 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 592029006649 active site 592029006650 intersubunit interactions; other site 592029006651 catalytic residue [active] 592029006652 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592029006653 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 592029006654 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029006655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029006656 ABC transporter; Region: ABC_tran_2; pfam12848 592029006657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592029006658 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 592029006659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006660 ATP binding site [chemical binding]; other site 592029006661 Mg2+ binding site [ion binding]; other site 592029006662 G-X-G motif; other site 592029006663 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 592029006664 ATP binding site [chemical binding]; other site 592029006665 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 592029006666 Rhomboid family; Region: Rhomboid; pfam01694 592029006667 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 592029006668 Predicted membrane protein [Function unknown]; Region: COG2860 592029006669 UPF0126 domain; Region: UPF0126; pfam03458 592029006670 UPF0126 domain; Region: UPF0126; pfam03458 592029006671 RDD family; Region: RDD; pfam06271 592029006672 Integral membrane protein DUF95; Region: DUF95; pfam01944 592029006673 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 592029006674 MoxR-like ATPases [General function prediction only]; Region: COG0714 592029006675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029006676 Walker A motif; other site 592029006677 ATP binding site [chemical binding]; other site 592029006678 Walker B motif; other site 592029006679 arginine finger; other site 592029006680 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 592029006681 Protein of unknown function DUF58; Region: DUF58; pfam01882 592029006682 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 592029006683 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029006684 catalytic residues [active] 592029006685 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592029006686 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 592029006687 dimer interface [polypeptide binding]; other site 592029006688 decamer (pentamer of dimers) interface [polypeptide binding]; other site 592029006689 catalytic triad [active] 592029006690 peroxidatic and resolving cysteines [active] 592029006691 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 592029006692 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592029006693 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592029006694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029006695 binding surface 592029006696 TPR repeat; Region: TPR_11; pfam13414 592029006697 TPR motif; other site 592029006698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 592029006699 Transposase; Region: DEDD_Tnp_IS110; pfam01548 592029006700 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 592029006701 Dot/Icm substrate protein; Region: SidE; pfam12252 592029006702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029006703 non-specific DNA binding site [nucleotide binding]; other site 592029006704 salt bridge; other site 592029006705 sequence-specific DNA binding site [nucleotide binding]; other site 592029006706 Domain of unknown function (DUF955); Region: DUF955; cl01076 592029006707 Transposase domain (DUF772); Region: DUF772; pfam05598 592029006708 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029006709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029006710 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029006711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029006712 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029006713 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 592029006714 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 592029006715 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 592029006716 active site 592029006717 integron integrase; Region: integrase_gron; TIGR02249 592029006718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592029006719 active site 592029006720 DNA binding site [nucleotide binding] 592029006721 Int/Topo IB signature motif; other site 592029006722 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029006723 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 592029006724 SmpB-tmRNA interface; other site 592029006725 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029006726 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006727 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592029006728 hydrophobic ligand binding site; other site 592029006729 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592029006730 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 592029006731 homodimer interface [polypeptide binding]; other site 592029006732 substrate-cofactor binding pocket; other site 592029006733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029006734 catalytic residue [active] 592029006735 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 592029006736 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 592029006737 IHF - DNA interface [nucleotide binding]; other site 592029006738 IHF dimer interface [polypeptide binding]; other site 592029006739 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 592029006740 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 592029006741 putative active site [active] 592029006742 substrate binding site [chemical binding]; other site 592029006743 putative cosubstrate binding site; other site 592029006744 catalytic site [active] 592029006745 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 592029006746 substrate binding site [chemical binding]; other site 592029006747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029006748 ATP binding site [chemical binding]; other site 592029006749 putative Mg++ binding site [ion binding]; other site 592029006750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029006751 nucleotide binding region [chemical binding]; other site 592029006752 ATP-binding site [chemical binding]; other site 592029006753 Predicted ATPase [General function prediction only]; Region: COG3911 592029006754 AAA domain; Region: AAA_28; pfam13521 592029006755 Protein of unknown function (DUF493); Region: DUF493; pfam04359 592029006756 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 592029006757 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 592029006758 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 592029006759 dimerization interface [polypeptide binding]; other site 592029006760 DPS ferroxidase diiron center [ion binding]; other site 592029006761 ion pore; other site 592029006762 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 592029006763 WbqC-like protein family; Region: WbqC; pfam08889 592029006764 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 592029006765 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592029006766 Catalytic site [active] 592029006767 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592029006768 dihydrodipicolinate reductase; Provisional; Region: PRK00048 592029006769 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 592029006770 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 592029006771 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 592029006772 ParB-like nuclease domain; Region: ParBc; pfam02195 592029006773 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592029006774 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592029006775 P-loop; other site 592029006776 Magnesium ion binding site [ion binding]; other site 592029006777 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592029006778 Magnesium ion binding site [ion binding]; other site 592029006779 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 592029006780 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029006781 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006782 Protein of unknown function (DUF808); Region: DUF808; cl01002 592029006783 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 592029006784 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 592029006785 catalytic residues [active] 592029006786 diaminopimelate decarboxylase; Region: lysA; TIGR01048 592029006787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 592029006788 active site 592029006789 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592029006790 substrate binding site [chemical binding]; other site 592029006791 catalytic residues [active] 592029006792 dimer interface [polypeptide binding]; other site 592029006793 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 592029006794 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 592029006795 CoA-ligase; Region: Ligase_CoA; pfam00549 592029006796 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 592029006797 active site 592029006798 dimer interface [polypeptide binding]; other site 592029006799 metal binding site [ion binding]; metal-binding site 592029006800 Proline dehydrogenase; Region: Pro_dh; cl03282 592029006801 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 592029006802 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 592029006803 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 592029006804 hexamer interface [polypeptide binding]; other site 592029006805 ligand binding site [chemical binding]; other site 592029006806 putative active site [active] 592029006807 NAD(P) binding site [chemical binding]; other site 592029006808 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 592029006809 Response regulator receiver domain; Region: Response_reg; pfam00072 592029006810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029006811 active site 592029006812 phosphorylation site [posttranslational modification] 592029006813 intermolecular recognition site; other site 592029006814 dimerization interface [polypeptide binding]; other site 592029006815 PglZ domain; Region: PglZ; pfam08665 592029006816 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 592029006817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029006818 Zn2+ binding site [ion binding]; other site 592029006819 Mg2+ binding site [ion binding]; other site 592029006820 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 592029006821 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 592029006822 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 592029006823 trimer interface [polypeptide binding]; other site 592029006824 active site 592029006825 UDP-GlcNAc binding site [chemical binding]; other site 592029006826 lipid binding site [chemical binding]; lipid-binding site 592029006827 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 592029006828 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 592029006829 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 592029006830 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 592029006831 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 592029006832 active site 592029006833 elongation factor P; Validated; Region: PRK00529 592029006834 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 592029006835 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 592029006836 RNA binding site [nucleotide binding]; other site 592029006837 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 592029006838 RNA binding site [nucleotide binding]; other site 592029006839 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 592029006840 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 592029006841 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 592029006842 trimer interface [polypeptide binding]; other site 592029006843 active site 592029006844 UDP-GlcNAc binding site [chemical binding]; other site 592029006845 lipid binding site [chemical binding]; lipid-binding site 592029006846 SnoaL-like domain; Region: SnoaL_2; pfam12680 592029006847 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 592029006848 CoA binding domain; Region: CoA_binding; smart00881 592029006849 CoA-ligase; Region: Ligase_CoA; pfam00549 592029006850 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 592029006851 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 592029006852 NAD(P) binding site [chemical binding]; other site 592029006853 homotetramer interface [polypeptide binding]; other site 592029006854 homodimer interface [polypeptide binding]; other site 592029006855 active site 592029006856 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 592029006857 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 592029006858 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029006859 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006860 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 592029006861 oligomerization interface [polypeptide binding]; other site 592029006862 active site 592029006863 metal binding site [ion binding]; metal-binding site 592029006864 mobile mystery protein B; Region: mob_myst_B; TIGR02613 592029006865 Fic/DOC family; Region: Fic; pfam02661 592029006866 mobile mystery protein A; Region: mob_myst_A; TIGR02612 592029006867 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 592029006868 sugar binding site [chemical binding]; other site 592029006869 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006870 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 592029006871 pentamer interface [polypeptide binding]; other site 592029006872 dodecaamer interface [polypeptide binding]; other site 592029006873 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592029006874 active site 592029006875 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 592029006876 putative active site [active] 592029006877 catalytic site [active] 592029006878 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 592029006879 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 592029006880 hinge; other site 592029006881 active site 592029006882 Repair protein; Region: Repair_PSII; pfam04536 592029006883 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 592029006884 pseudouridine synthase; Region: TIGR00093 592029006885 active site 592029006886 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592029006887 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592029006888 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029006889 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 592029006890 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 592029006891 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 592029006892 NAD(P) binding site [chemical binding]; other site 592029006893 catalytic residues [active] 592029006894 NMT1/THI5 like; Region: NMT1; pfam09084 592029006895 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592029006896 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592029006897 active site 592029006898 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 592029006899 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 592029006900 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 592029006901 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 592029006902 oligomer interface [polypeptide binding]; other site 592029006903 active site 592029006904 metal binding site [ion binding]; metal-binding site 592029006905 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 592029006906 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 592029006907 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 592029006908 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 592029006909 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592029006910 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592029006911 ligand binding site [chemical binding]; other site 592029006912 flexible hinge region; other site 592029006913 Pirin; Region: Pirin; pfam02678 592029006914 Pirin-related protein [General function prediction only]; Region: COG1741 592029006915 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 592029006916 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 592029006917 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592029006918 DNA binding site [nucleotide binding] 592029006919 active site 592029006920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029006921 FtsX-like permease family; Region: FtsX; pfam02687 592029006922 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 592029006923 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 592029006924 dimer interface [polypeptide binding]; other site 592029006925 motif 1; other site 592029006926 active site 592029006927 motif 2; other site 592029006928 motif 3; other site 592029006929 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 592029006930 anticodon binding site; other site 592029006931 DinB family; Region: DinB; cl17821 592029006932 DinB superfamily; Region: DinB_2; pfam12867 592029006933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 592029006934 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 592029006935 ligand binding site [chemical binding]; other site 592029006936 flexible hinge region; other site 592029006937 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 592029006938 putative catalytic residues [active] 592029006939 short chain dehydrogenase; Provisional; Region: PRK06180 592029006940 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592029006941 NADP binding site [chemical binding]; other site 592029006942 active site 592029006943 steroid binding site; other site 592029006944 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592029006945 homotrimer interaction site [polypeptide binding]; other site 592029006946 putative active site [active] 592029006947 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 592029006948 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592029006949 Walker A/P-loop; other site 592029006950 ATP binding site [chemical binding]; other site 592029006951 Q-loop/lid; other site 592029006952 ABC transporter signature motif; other site 592029006953 Walker B; other site 592029006954 D-loop; other site 592029006955 H-loop/switch region; other site 592029006956 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 592029006957 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592029006958 ABC-ATPase subunit interface; other site 592029006959 dimer interface [polypeptide binding]; other site 592029006960 putative PBP binding regions; other site 592029006961 Fic family protein [Function unknown]; Region: COG3177 592029006962 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 592029006963 Fic/DOC family; Region: Fic; pfam02661 592029006964 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 592029006965 Protein of unknown function, DUF481; Region: DUF481; cl01213 592029006966 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 592029006967 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 592029006968 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592029006969 Methyltransferase domain; Region: Methyltransf_26; pfam13659 592029006970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029006971 sequence-specific DNA binding site [nucleotide binding]; other site 592029006972 salt bridge; other site 592029006973 PIN domain; Region: PIN_3; cl17397 592029006974 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 592029006975 dimer interface [polypeptide binding]; other site 592029006976 putative active site [active] 592029006977 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 592029006978 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 592029006979 ATP binding site [chemical binding]; other site 592029006980 active site 592029006981 substrate binding site [chemical binding]; other site 592029006982 Family of unknown function (DUF490); Region: DUF490; pfam04357 592029006983 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029006984 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 592029006985 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 592029006986 NAD(P) binding site [chemical binding]; other site 592029006987 catalytic residues [active] 592029006988 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006989 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 592029006990 active site 592029006991 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 592029006992 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 592029006993 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029006994 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 592029006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029006996 ATP binding site [chemical binding]; other site 592029006997 Mg2+ binding site [ion binding]; other site 592029006998 G-X-G motif; other site 592029006999 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 592029007000 ATP binding site [chemical binding]; other site 592029007001 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 592029007002 active site 592029007003 putative metal-binding site [ion binding]; other site 592029007004 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592029007005 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 592029007006 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 592029007007 CAP-like domain; other site 592029007008 active site 592029007009 primary dimer interface [polypeptide binding]; other site 592029007010 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 592029007011 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 592029007012 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 592029007013 putative active site [active] 592029007014 Zn binding site [ion binding]; other site 592029007015 Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300 592029007016 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 592029007017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592029007018 putative DNA binding site [nucleotide binding]; other site 592029007019 putative Zn2+ binding site [ion binding]; other site 592029007020 AsnC family; Region: AsnC_trans_reg; pfam01037 592029007021 DinB superfamily; Region: DinB_2; pfam12867 592029007022 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 592029007023 intracellular protease, PfpI family; Region: PfpI; TIGR01382 592029007024 proposed catalytic triad [active] 592029007025 conserved cys residue [active] 592029007026 DNA polymerase III subunit beta; Validated; Region: PRK05643 592029007027 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 592029007028 putative DNA binding surface [nucleotide binding]; other site 592029007029 dimer interface [polypeptide binding]; other site 592029007030 beta-clamp/clamp loader binding surface; other site 592029007031 beta-clamp/translesion DNA polymerase binding surface; other site 592029007032 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 592029007033 active site 592029007034 catalytic triad [active] 592029007035 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007036 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 592029007037 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592029007038 catalytic residues [active] 592029007039 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 592029007040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029007041 ATP binding site [chemical binding]; other site 592029007042 putative Mg++ binding site [ion binding]; other site 592029007043 helicase superfamily c-terminal domain; Region: HELICc; smart00490 592029007044 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029007045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029007046 active site 592029007047 phosphorylation site [posttranslational modification] 592029007048 intermolecular recognition site; other site 592029007049 dimerization interface [polypeptide binding]; other site 592029007050 LytTr DNA-binding domain; Region: LytTR; smart00850 592029007051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 592029007052 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 592029007053 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 592029007054 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 592029007055 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 592029007056 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029007057 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029007058 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029007059 peptide chain release factor 2; Validated; Region: prfB; PRK00578 592029007060 PCRF domain; Region: PCRF; pfam03462 592029007061 RF-1 domain; Region: RF-1; pfam00472 592029007062 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 592029007063 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 592029007064 tetramer interface [polypeptide binding]; other site 592029007065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029007066 catalytic residue [active] 592029007067 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029007068 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029007069 ligand binding site [chemical binding]; other site 592029007070 Protein of unknown function, DUF479; Region: DUF479; cl01203 592029007071 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 592029007072 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 592029007073 active site 592029007074 substrate binding site [chemical binding]; other site 592029007075 metal binding site [ion binding]; metal-binding site 592029007076 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 592029007077 putative acyl-acceptor binding pocket; other site 592029007078 Rhomboid family; Region: Rhomboid; pfam01694 592029007079 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 592029007080 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029007081 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029007082 catalytic residues [active] 592029007083 GAF domain; Region: GAF_2; pfam13185 592029007084 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029007085 Zn2+ binding site [ion binding]; other site 592029007086 Mg2+ binding site [ion binding]; other site 592029007087 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 592029007088 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592029007089 active site 592029007090 metal binding site [ion binding]; metal-binding site 592029007091 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029007092 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592029007093 Putative esterase; Region: Esterase; pfam00756 592029007094 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592029007095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029007096 active site 592029007097 phosphorylation site [posttranslational modification] 592029007098 intermolecular recognition site; other site 592029007099 dimerization interface [polypeptide binding]; other site 592029007100 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592029007101 DNA binding residues [nucleotide binding] 592029007102 dimerization interface [polypeptide binding]; other site 592029007103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 592029007104 Histidine kinase; Region: HisKA_3; pfam07730 592029007105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029007106 ATP binding site [chemical binding]; other site 592029007107 Mg2+ binding site [ion binding]; other site 592029007108 G-X-G motif; other site 592029007109 Peptidase family M49; Region: Peptidase_M49; pfam03571 592029007110 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 592029007111 metal binding site [ion binding]; metal-binding site 592029007112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007113 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 592029007114 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029007115 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 592029007116 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029007117 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 592029007118 putative SAM binding site [chemical binding]; other site 592029007119 homodimer interface [polypeptide binding]; other site 592029007120 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592029007121 active site 592029007122 catalytic site [active] 592029007123 substrate binding site [chemical binding]; other site 592029007124 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 592029007125 GIY-YIG motif/motif A; other site 592029007126 active site 592029007127 catalytic site [active] 592029007128 metal binding site [ion binding]; metal-binding site 592029007129 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 592029007130 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 592029007131 acyl-activating enzyme (AAE) consensus motif; other site 592029007132 putative AMP binding site [chemical binding]; other site 592029007133 putative active site [active] 592029007134 putative CoA binding site [chemical binding]; other site 592029007135 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007136 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 592029007137 Clp amino terminal domain; Region: Clp_N; pfam02861 592029007138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029007139 Walker A motif; other site 592029007140 ATP binding site [chemical binding]; other site 592029007141 Walker B motif; other site 592029007142 arginine finger; other site 592029007143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029007144 Walker A motif; other site 592029007145 ATP binding site [chemical binding]; other site 592029007146 Walker B motif; other site 592029007147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592029007148 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 592029007149 Peptidase family M48; Region: Peptidase_M48; pfam01435 592029007150 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 592029007151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029007152 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 592029007153 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 592029007154 dimer interface [polypeptide binding]; other site 592029007155 active site 592029007156 heme binding site [chemical binding]; other site 592029007157 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 592029007158 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 592029007159 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029007160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029007161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029007162 DNA binding residues [nucleotide binding] 592029007163 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 592029007164 Found in ATP-dependent protease La (LON); Region: LON; smart00464 592029007165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592029007166 Walker A motif; other site 592029007167 ATP binding site [chemical binding]; other site 592029007168 Walker B motif; other site 592029007169 arginine finger; other site 592029007170 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 592029007171 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592029007172 endonuclease III; Region: ENDO3c; smart00478 592029007173 minor groove reading motif; other site 592029007174 helix-hairpin-helix signature motif; other site 592029007175 substrate binding pocket [chemical binding]; other site 592029007176 active site 592029007177 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592029007178 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 592029007179 catalytic triad [active] 592029007180 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 592029007181 putative hydrolase; Provisional; Region: PRK02113 592029007182 Protein of unknown function DUF86; Region: DUF86; cl01031 592029007183 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 592029007184 active site 592029007185 NTP binding site [chemical binding]; other site 592029007186 metal binding triad [ion binding]; metal-binding site 592029007187 antibiotic binding site [chemical binding]; other site 592029007188 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 592029007189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 592029007190 ATP binding site [chemical binding]; other site 592029007191 putative Mg++ binding site [ion binding]; other site 592029007192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029007193 nucleotide binding region [chemical binding]; other site 592029007194 ATP-binding site [chemical binding]; other site 592029007195 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 592029007196 RNA binding site [nucleotide binding]; other site 592029007197 Predicted esterase [General function prediction only]; Region: COG0400 592029007198 putative hydrolase; Provisional; Region: PRK11460 592029007199 dihydroorotase; Validated; Region: pyrC; PRK09357 592029007200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592029007201 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 592029007202 active site 592029007203 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 592029007204 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592029007205 GAF domain; Region: GAF; pfam01590 592029007206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029007207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029007208 ATP binding site [chemical binding]; other site 592029007209 Mg2+ binding site [ion binding]; other site 592029007210 G-X-G motif; other site 592029007211 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 592029007212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592029007213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029007214 Walker A/P-loop; other site 592029007215 ATP binding site [chemical binding]; other site 592029007216 Q-loop/lid; other site 592029007217 ABC transporter signature motif; other site 592029007218 Walker B; other site 592029007219 D-loop; other site 592029007220 H-loop/switch region; other site 592029007221 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 592029007222 putative ligand binding site [chemical binding]; other site 592029007223 methionine sulfoxide reductase A; Provisional; Region: PRK14054 592029007224 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 592029007225 homodecamer interface [polypeptide binding]; other site 592029007226 GTP cyclohydrolase I; Provisional; Region: PLN03044 592029007227 active site 592029007228 putative catalytic site residues [active] 592029007229 zinc binding site [ion binding]; other site 592029007230 GTP-CH-I/GFRP interaction surface; other site 592029007231 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592029007232 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592029007233 active site 592029007234 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029007235 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 592029007236 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 592029007237 Tetramer interface [polypeptide binding]; other site 592029007238 active site 592029007239 FMN-binding site [chemical binding]; other site 592029007240 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592029007241 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 592029007242 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 592029007243 glutathione synthetase; Provisional; Region: PRK12458 592029007244 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 592029007245 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 592029007246 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 592029007247 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007248 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 592029007249 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 592029007250 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592029007251 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592029007252 active site 592029007253 metal binding site [ion binding]; metal-binding site 592029007254 Sporulation related domain; Region: SPOR; cl10051 592029007255 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 592029007256 mce related protein; Region: MCE; pfam02470 592029007257 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 592029007258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029007259 active site 592029007260 motif I; other site 592029007261 motif II; other site 592029007262 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592029007263 Cysteine-rich domain; Region: CCG; pfam02754 592029007264 Cysteine-rich domain; Region: CCG; pfam02754 592029007265 Tim44-like domain; Region: Tim44; cl09208 592029007266 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 592029007267 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 592029007268 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029007269 Beta-lactamase; Region: Beta-lactamase; cl17358 592029007270 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 592029007271 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 592029007272 PrcB C-terminal; Region: PrcB_C; pfam14343 592029007273 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 592029007274 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592029007275 dimer interface [polypeptide binding]; other site 592029007276 ADP-ribose binding site [chemical binding]; other site 592029007277 active site 592029007278 nudix motif; other site 592029007279 metal binding site [ion binding]; metal-binding site 592029007280 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592029007282 Amidohydrolase; Region: Amidohydro_4; pfam13147 592029007283 active site 592029007284 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592029007285 Amidohydrolase; Region: Amidohydro_4; pfam13147 592029007286 active site 592029007287 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 592029007288 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 592029007289 active site 592029007290 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 592029007291 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 592029007292 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 592029007293 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 592029007294 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 592029007295 active site 592029007296 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592029007297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029007298 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029007299 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 592029007300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029007301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029007302 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592029007303 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 592029007304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592029007305 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 592029007306 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 592029007307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029007308 motif II; other site 592029007309 TIR domain; Region: TIR_2; pfam13676 592029007310 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592029007311 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592029007312 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 592029007313 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592029007314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 592029007315 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 592029007316 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 592029007317 active site 592029007318 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 592029007319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029007320 binding surface 592029007321 TPR motif; other site 592029007322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029007323 binding surface 592029007324 TPR motif; other site 592029007325 TPR repeat; Region: TPR_11; pfam13414 592029007326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029007327 binding surface 592029007328 TPR motif; other site 592029007329 TPR repeat; Region: TPR_11; pfam13414 592029007330 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 592029007331 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029007332 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 592029007333 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 592029007334 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592029007335 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029007336 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029007337 ligand binding site [chemical binding]; other site 592029007338 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 592029007339 30S subunit binding site; other site 592029007340 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 592029007341 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 592029007342 oligomeric interface; other site 592029007343 homodimer interface [polypeptide binding]; other site 592029007344 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 592029007345 putative FMN binding site [chemical binding]; other site 592029007346 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 592029007347 Phosphopantetheine attachment site; Region: PP-binding; cl09936 592029007348 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 592029007349 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592029007350 dimer interface [polypeptide binding]; other site 592029007351 active site 592029007352 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592029007353 Surface antigen; Region: Bac_surface_Ag; pfam01103 592029007354 Protein of unknown function, DUF547; Region: DUF547; pfam04784 592029007355 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 592029007356 active site 2 [active] 592029007357 active site 1 [active] 592029007358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029007359 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 592029007360 NAD(P) binding site [chemical binding]; other site 592029007361 active site 592029007362 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 592029007363 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 592029007364 malonyl-CoA binding site [chemical binding]; other site 592029007365 dimer interface [polypeptide binding]; other site 592029007366 active site 592029007367 product binding site; other site 592029007368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592029007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029007370 S-adenosylmethionine binding site [chemical binding]; other site 592029007371 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 592029007372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029007373 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 592029007374 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592029007375 tetramer interface [polypeptide binding]; other site 592029007376 TPP-binding site [chemical binding]; other site 592029007377 heterodimer interface [polypeptide binding]; other site 592029007378 phosphorylation loop region [posttranslational modification] 592029007379 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592029007380 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 592029007381 alpha subunit interface [polypeptide binding]; other site 592029007382 TPP binding site [chemical binding]; other site 592029007383 heterodimer interface [polypeptide binding]; other site 592029007384 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592029007385 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 592029007386 active site 592029007387 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592029007388 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 592029007389 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 592029007390 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 592029007391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 592029007392 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 592029007393 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592029007394 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592029007395 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 592029007396 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592029007397 NAD(P) binding site [chemical binding]; other site 592029007398 catalytic residues [active] 592029007399 Protein of unknown function (DUF779); Region: DUF779; pfam05610 592029007400 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 592029007401 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592029007402 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592029007403 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 592029007404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592029007405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592029007406 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 592029007407 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 592029007408 Predicted membrane protein [Function unknown]; Region: COG4270 592029007409 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 592029007410 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 592029007411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029007412 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592029007413 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029007414 DNA binding residues [nucleotide binding] 592029007415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592029007416 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 592029007417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029007418 non-specific DNA binding site [nucleotide binding]; other site 592029007419 salt bridge; other site 592029007420 sequence-specific DNA binding site [nucleotide binding]; other site 592029007421 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 592029007422 thiamine phosphate binding site [chemical binding]; other site 592029007423 active site 592029007424 pyrophosphate binding site [ion binding]; other site 592029007425 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 592029007426 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592029007427 cofactor binding site; other site 592029007428 DNA binding site [nucleotide binding] 592029007429 substrate interaction site [chemical binding]; other site 592029007430 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 592029007431 ParB-like nuclease domain; Region: ParBc; pfam02195 592029007432 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029007433 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029007434 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 592029007435 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 592029007436 PhnA protein; Region: PhnA; pfam03831 592029007437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592029007438 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 592029007439 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029007440 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029007441 integral membrane protein; Region: integ_memb_HG; TIGR03954 592029007442 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 592029007443 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592029007444 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 592029007445 Peptidase family M48; Region: Peptidase_M48; pfam01435 592029007446 DoxX-like family; Region: DoxX_2; pfam13564 592029007447 GAF domain; Region: GAF; pfam01590 592029007448 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592029007449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029007450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029007451 dimer interface [polypeptide binding]; other site 592029007452 phosphorylation site [posttranslational modification] 592029007453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029007454 ATP binding site [chemical binding]; other site 592029007455 Mg2+ binding site [ion binding]; other site 592029007456 G-X-G motif; other site 592029007457 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 592029007458 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 592029007459 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 592029007460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029007461 NAD(P) binding site [chemical binding]; other site 592029007462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029007463 active site 592029007464 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 592029007465 EamA-like transporter family; Region: EamA; pfam00892 592029007466 EamA-like transporter family; Region: EamA; pfam00892 592029007467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 592029007469 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029007470 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592029007471 DNA-binding site [nucleotide binding]; DNA binding site 592029007472 RNA-binding motif; other site 592029007473 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592029007474 HSP70 interaction site [polypeptide binding]; other site 592029007475 KTSC domain; Region: KTSC; pfam13619 592029007476 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 592029007477 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 592029007478 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 592029007479 trimer interface [polypeptide binding]; other site 592029007480 active site 592029007481 UDP-GlcNAc binding site [chemical binding]; other site 592029007482 lipid binding site [chemical binding]; lipid-binding site 592029007483 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592029007484 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592029007485 putative NAD(P) binding site [chemical binding]; other site 592029007486 putative substrate binding site [chemical binding]; other site 592029007487 catalytic Zn binding site [ion binding]; other site 592029007488 structural Zn binding site [ion binding]; other site 592029007489 dimer interface [polypeptide binding]; other site 592029007490 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 592029007491 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592029007492 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 592029007493 putative dimer interface [polypeptide binding]; other site 592029007494 tellurium resistance terB-like protein; Region: terB_like; cd07177 592029007495 metal binding site [ion binding]; metal-binding site 592029007496 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 592029007497 Predicted membrane protein [Function unknown]; Region: COG4325 592029007498 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 592029007499 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 592029007500 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 592029007501 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 592029007502 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 592029007503 dimerization interface [polypeptide binding]; other site 592029007504 active site 592029007505 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 592029007506 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 592029007507 MutS domain III; Region: MutS_III; pfam05192 592029007508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029007509 Walker A/P-loop; other site 592029007510 ATP binding site [chemical binding]; other site 592029007511 Q-loop/lid; other site 592029007512 ABC transporter signature motif; other site 592029007513 Walker B; other site 592029007514 D-loop; other site 592029007515 H-loop/switch region; other site 592029007516 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 592029007517 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 592029007518 Uncharacterized conserved protein [Function unknown]; Region: COG3743 592029007519 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 592029007520 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592029007521 N-terminal plug; other site 592029007522 ligand-binding site [chemical binding]; other site 592029007523 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 592029007524 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592029007525 putative ligand binding site [chemical binding]; other site 592029007526 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 592029007527 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 592029007528 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 592029007529 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 592029007530 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 592029007531 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 592029007532 Ligand binding site; other site 592029007533 Putative Catalytic site; other site 592029007534 DXD motif; other site 592029007535 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 592029007536 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 592029007537 active site 592029007538 substrate binding site [chemical binding]; other site 592029007539 metal binding site [ion binding]; metal-binding site 592029007540 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 592029007541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592029007542 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 592029007543 Walker A/P-loop; other site 592029007544 ATP binding site [chemical binding]; other site 592029007545 Q-loop/lid; other site 592029007546 ABC transporter signature motif; other site 592029007547 Walker B; other site 592029007548 D-loop; other site 592029007549 H-loop/switch region; other site 592029007550 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 592029007551 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592029007552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592029007553 substrate binding pocket [chemical binding]; other site 592029007554 membrane-bound complex binding site; other site 592029007555 hinge residues; other site 592029007556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029007557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029007558 dimer interface [polypeptide binding]; other site 592029007559 phosphorylation site [posttranslational modification] 592029007560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029007561 ATP binding site [chemical binding]; other site 592029007562 Mg2+ binding site [ion binding]; other site 592029007563 G-X-G motif; other site 592029007564 Response regulator receiver domain; Region: Response_reg; pfam00072 592029007565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029007566 active site 592029007567 phosphorylation site [posttranslational modification] 592029007568 intermolecular recognition site; other site 592029007569 dimerization interface [polypeptide binding]; other site 592029007570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592029007571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592029007572 active site 592029007573 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 592029007574 RmuC family; Region: RmuC; pfam02646 592029007575 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 592029007576 metal binding site [ion binding]; metal-binding site 592029007577 nucleotidyl binding site; other site 592029007578 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 592029007579 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592029007580 aspartate kinase III; Validated; Region: PRK09084 592029007581 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 592029007582 nucleotide binding site [chemical binding]; other site 592029007583 substrate binding site [chemical binding]; other site 592029007584 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 592029007585 dimer interface [polypeptide binding]; other site 592029007586 allosteric regulatory binding pocket; other site 592029007587 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 592029007588 Family description; Region: ACT_7; pfam13840 592029007589 Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; Region: Reeler; cd08544 592029007590 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007591 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 592029007592 YceI-like domain; Region: YceI; pfam04264 592029007593 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029007594 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029007595 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 592029007596 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029007597 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592029007598 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 592029007599 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592029007600 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 592029007601 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 592029007602 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592029007603 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 592029007604 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592029007605 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 592029007606 active site 592029007607 multimer interface [polypeptide binding]; other site 592029007608 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 592029007609 DHH family; Region: DHH; pfam01368 592029007610 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 592029007611 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592029007612 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 592029007613 active site 592029007614 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592029007615 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592029007616 homotrimer interaction site [polypeptide binding]; other site 592029007617 putative active site [active] 592029007618 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 592029007619 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 592029007620 polyphosphate kinase; Provisional; Region: PRK05443 592029007621 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 592029007622 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 592029007623 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 592029007624 domain interface [polypeptide binding]; other site 592029007625 active site 592029007626 catalytic site [active] 592029007627 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 592029007628 domain interface [polypeptide binding]; other site 592029007629 active site 592029007630 catalytic site [active] 592029007631 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 592029007632 YARHG domain; Region: YARHG; pfam13308 592029007633 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 592029007634 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592029007635 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 592029007636 FMN binding site [chemical binding]; other site 592029007637 active site 592029007638 catalytic residues [active] 592029007639 substrate binding site [chemical binding]; other site 592029007640 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 592029007641 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 592029007642 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 592029007643 nucleotide binding site [chemical binding]; other site 592029007644 substrate binding site [chemical binding]; other site 592029007645 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 592029007646 dimer interface [polypeptide binding]; other site 592029007647 putative threonine allosteric regulatory site; other site 592029007648 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 592029007649 putative threonine allosteric regulatory site; other site 592029007650 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 592029007651 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 592029007652 homoserine kinase; Provisional; Region: PRK01212 592029007653 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592029007654 threonine synthase; Validated; Region: PRK09225 592029007655 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 592029007656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029007657 catalytic residue [active] 592029007658 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 592029007659 16S rRNA methyltransferase B; Provisional; Region: PRK14902 592029007660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029007661 Endonuclease I; Region: Endonuclease_1; pfam04231 592029007662 Lamin Tail Domain; Region: LTD; pfam00932 592029007663 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007664 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592029007665 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 592029007666 putative NAD(P) binding site [chemical binding]; other site 592029007667 putative substrate binding site [chemical binding]; other site 592029007668 catalytic Zn binding site [ion binding]; other site 592029007669 structural Zn binding site [ion binding]; other site 592029007670 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 592029007671 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 592029007672 dimerization interface [polypeptide binding]; other site 592029007673 ATP binding site [chemical binding]; other site 592029007674 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 592029007675 dimerization interface [polypeptide binding]; other site 592029007676 ATP binding site [chemical binding]; other site 592029007677 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 592029007678 putative active site [active] 592029007679 catalytic triad [active] 592029007680 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 592029007681 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592029007682 cofactor binding site; other site 592029007683 DNA binding site [nucleotide binding] 592029007684 substrate interaction site [chemical binding]; other site 592029007685 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592029007686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 592029007687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029007688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029007689 ATP binding site [chemical binding]; other site 592029007690 Mg2+ binding site [ion binding]; other site 592029007691 G-X-G motif; other site 592029007692 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592029007693 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 592029007694 NAD(P) binding site [chemical binding]; other site 592029007695 catalytic residues [active] 592029007696 ribonuclease Z; Reviewed; Region: PRK00055 592029007697 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 592029007698 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592029007699 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592029007700 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592029007701 active site 592029007702 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 592029007703 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 592029007704 RNA binding site [nucleotide binding]; other site 592029007705 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 592029007706 RNA binding site [nucleotide binding]; other site 592029007707 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592029007708 RNA binding site [nucleotide binding]; other site 592029007709 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592029007710 RNA binding site [nucleotide binding]; other site 592029007711 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592029007712 RNA binding site [nucleotide binding]; other site 592029007713 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592029007714 RNA binding site [nucleotide binding]; other site 592029007715 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 592029007716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592029007717 catalytic core [active] 592029007718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592029007719 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 592029007720 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 592029007721 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 592029007722 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 592029007723 E-class dimer interface [polypeptide binding]; other site 592029007724 P-class dimer interface [polypeptide binding]; other site 592029007725 active site 592029007726 Cu2+ binding site [ion binding]; other site 592029007727 Zn2+ binding site [ion binding]; other site 592029007728 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 592029007729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029007730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 592029007731 DNA binding residues [nucleotide binding] 592029007732 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 592029007733 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 592029007734 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 592029007735 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 592029007736 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592029007737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029007738 active site 592029007739 phosphorylation site [posttranslational modification] 592029007740 intermolecular recognition site; other site 592029007741 dimerization interface [polypeptide binding]; other site 592029007742 LytTr DNA-binding domain; Region: LytTR; smart00850 592029007743 2TM domain; Region: 2TM; pfam13239 592029007744 2TM domain; Region: 2TM; pfam13239 592029007745 Histidine kinase; Region: His_kinase; pfam06580 592029007746 2TM domain; Region: 2TM; pfam13239 592029007747 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 592029007748 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 592029007749 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 592029007750 active site 592029007751 Zn binding site [ion binding]; other site 592029007752 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 592029007753 active site 592029007754 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 592029007755 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007756 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 592029007757 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 592029007758 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 592029007759 WYL domain; Region: WYL; pfam13280 592029007760 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 592029007761 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 592029007762 metal binding site [ion binding]; metal-binding site 592029007763 dimer interface [polypeptide binding]; other site 592029007764 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 592029007765 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 592029007766 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 592029007767 homodimer interface [polypeptide binding]; other site 592029007768 substrate-cofactor binding pocket; other site 592029007769 catalytic residue [active] 592029007770 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029007771 excinuclease ABC subunit B; Provisional; Region: PRK05298 592029007772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029007773 ATP binding site [chemical binding]; other site 592029007774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029007775 nucleotide binding region [chemical binding]; other site 592029007776 ATP-binding site [chemical binding]; other site 592029007777 Ultra-violet resistance protein B; Region: UvrB; pfam12344 592029007778 UvrB/uvrC motif; Region: UVR; pfam02151 592029007779 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592029007780 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592029007781 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 592029007782 putative rRNA binding site [nucleotide binding]; other site 592029007783 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 592029007784 aromatic arch; other site 592029007785 DCoH dimer interaction site [polypeptide binding]; other site 592029007786 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 592029007787 DCoH tetramer interaction site [polypeptide binding]; other site 592029007788 substrate binding site [chemical binding]; other site 592029007789 CsbD-like; Region: CsbD; pfam05532 592029007790 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029007791 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 592029007792 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 592029007793 ATP-binding site [chemical binding]; other site 592029007794 Sugar specificity; other site 592029007795 Pyrimidine base specificity; other site 592029007796 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 592029007797 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 592029007798 heterodimer interface [polypeptide binding]; other site 592029007799 substrate interaction site [chemical binding]; other site 592029007800 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 592029007801 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 592029007802 active site 592029007803 substrate binding site [chemical binding]; other site 592029007804 coenzyme B12 binding site [chemical binding]; other site 592029007805 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 592029007806 B12 binding site [chemical binding]; other site 592029007807 cobalt ligand [ion binding]; other site 592029007808 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029007809 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 592029007810 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029007811 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 592029007812 4Fe-4S binding domain; Region: Fer4; cl02805 592029007813 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 592029007814 NAD(P) binding site [chemical binding]; other site 592029007815 catalytic residues [active] 592029007816 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 592029007817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029007818 catalytic residue [active] 592029007819 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592029007820 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 592029007821 putative ligand binding site [chemical binding]; other site 592029007822 NAD binding site [chemical binding]; other site 592029007823 dimerization interface [polypeptide binding]; other site 592029007824 catalytic site [active] 592029007825 Pirin; Region: Pirin; pfam02678 592029007826 Pirin-related protein [General function prediction only]; Region: COG1741 592029007827 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592029007828 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 592029007829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 592029007830 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 592029007831 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 592029007832 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 592029007833 Rossmann-like domain; Region: Rossmann-like; pfam10727 592029007834 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 592029007835 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 592029007836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592029007837 active site 592029007838 motif I; other site 592029007839 motif II; other site 592029007840 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 592029007841 UbiA prenyltransferase family; Region: UbiA; pfam01040 592029007842 Maf-like protein; Reviewed; Region: PRK00078 592029007843 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 592029007844 active site 592029007845 dimer interface [polypeptide binding]; other site 592029007846 BetR domain; Region: BetR; pfam08667 592029007847 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 592029007848 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 592029007849 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 592029007850 dimer interface [polypeptide binding]; other site 592029007851 tetramer interface [polypeptide binding]; other site 592029007852 PYR/PP interface [polypeptide binding]; other site 592029007853 TPP binding site [chemical binding]; other site 592029007854 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 592029007855 TPP-binding site; other site 592029007856 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592029007857 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 592029007858 CoenzymeA binding site [chemical binding]; other site 592029007859 subunit interaction site [polypeptide binding]; other site 592029007860 PHB binding site; other site 592029007861 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 592029007862 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 592029007863 active site 592029007864 dimerization interface [polypeptide binding]; other site 592029007865 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029007866 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 592029007867 Peptidase family M28; Region: Peptidase_M28; pfam04389 592029007868 metal binding site [ion binding]; metal-binding site 592029007869 DEAD-like helicases superfamily; Region: DEXDc; smart00487 592029007870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592029007871 ATP binding site [chemical binding]; other site 592029007872 putative Mg++ binding site [ion binding]; other site 592029007873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592029007874 nucleotide binding region [chemical binding]; other site 592029007875 ATP-binding site [chemical binding]; other site 592029007876 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 592029007877 fumarate hydratase; Reviewed; Region: fumC; PRK00485 592029007878 Class II fumarases; Region: Fumarase_classII; cd01362 592029007879 active site 592029007880 tetramer interface [polypeptide binding]; other site 592029007881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592029007882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592029007883 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 592029007884 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 592029007885 active site 592029007886 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 592029007887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592029007888 Zn2+ binding site [ion binding]; other site 592029007889 Mg2+ binding site [ion binding]; other site 592029007890 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 592029007891 synthetase active site [active] 592029007892 NTP binding site [chemical binding]; other site 592029007893 metal binding site [ion binding]; metal-binding site 592029007894 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 592029007895 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 592029007896 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592029007897 metal binding site 2 [ion binding]; metal-binding site 592029007898 putative DNA binding helix; other site 592029007899 metal binding site 1 [ion binding]; metal-binding site 592029007900 dimer interface [polypeptide binding]; other site 592029007901 structural Zn2+ binding site [ion binding]; other site 592029007902 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 592029007903 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 592029007904 GDP-binding site [chemical binding]; other site 592029007905 ACT binding site; other site 592029007906 IMP binding site; other site 592029007907 Domain of unknown function (DUF368); Region: DUF368; pfam04018 592029007908 Domain of unknown function (DUF368); Region: DUF368; pfam04018 592029007909 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 592029007910 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592029007911 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592029007912 shikimate binding site; other site 592029007913 NAD(P) binding site [chemical binding]; other site 592029007914 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 592029007915 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 592029007916 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 592029007917 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 592029007918 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 592029007919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592029007920 nucleotide binding site [chemical binding]; other site 592029007921 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 592029007922 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 592029007923 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592029007924 6-phosphofructokinase; Provisional; Region: PRK03202 592029007925 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 592029007926 active site 592029007927 ADP/pyrophosphate binding site [chemical binding]; other site 592029007928 dimerization interface [polypeptide binding]; other site 592029007929 allosteric effector site; other site 592029007930 fructose-1,6-bisphosphate binding site; other site 592029007931 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 592029007932 Na binding site [ion binding]; other site 592029007933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007934 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029007935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007936 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029007937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007939 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029007940 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 592029007941 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 592029007942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029007943 sequence-specific DNA binding site [nucleotide binding]; other site 592029007944 salt bridge; other site 592029007945 Transposase; Region: DEDD_Tnp_IS110; pfam01548 592029007946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 592029007947 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 592029007948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 592029007949 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 592029007950 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 592029007951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 592029007952 Transposase; Region: DEDD_Tnp_IS110; pfam01548 592029007953 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 592029007954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592029007955 dimerization interface [polypeptide binding]; other site 592029007956 putative DNA binding site [nucleotide binding]; other site 592029007957 putative Zn2+ binding site [ion binding]; other site 592029007958 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 592029007959 SdpI/YhfL protein family; Region: SdpI; pfam13630 592029007960 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592029007961 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029007962 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592029007963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592029007964 non-specific DNA binding site [nucleotide binding]; other site 592029007965 salt bridge; other site 592029007966 sequence-specific DNA binding site [nucleotide binding]; other site 592029007967 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592029007968 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 592029007969 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 592029007970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592029007971 catalytic residues [active] 592029007972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592029007973 Beta-lactamase; Region: Beta-lactamase; pfam00144 592029007974 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 592029007975 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592029007976 conserved cys residue [active] 592029007977 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 592029007978 Protein of unknown function (DUF421); Region: DUF421; pfam04239 592029007979 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 592029007980 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 592029007981 catalytic nucleophile [active] 592029007982 cyanophycin synthetase; Provisional; Region: PRK14016 592029007983 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592029007984 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592029007985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592029007986 putative carbohydrate kinase; Provisional; Region: PRK10565 592029007987 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 592029007988 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 592029007989 putative substrate binding site [chemical binding]; other site 592029007990 putative ATP binding site [chemical binding]; other site 592029007991 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 592029007992 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 592029007993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029007994 NAD(P) binding site [chemical binding]; other site 592029007995 active site 592029007996 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 592029007997 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 592029007998 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592029007999 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 592029008000 substrate binding site [chemical binding]; other site 592029008001 oxyanion hole (OAH) forming residues; other site 592029008002 trimer interface [polypeptide binding]; other site 592029008003 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 592029008004 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 592029008005 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 592029008006 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 592029008007 Penicillinase repressor; Region: Pencillinase_R; pfam03965 592029008008 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 592029008009 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 592029008010 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 592029008011 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 592029008012 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 592029008013 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 592029008014 Catalytic dyad [active] 592029008015 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592029008016 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592029008017 active site 592029008018 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 592029008019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592029008020 FtsX-like permease family; Region: FtsX; pfam02687 592029008021 FtsX-like permease family; Region: FtsX; pfam02687 592029008022 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592029008023 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 592029008024 Walker A/P-loop; other site 592029008025 ATP binding site [chemical binding]; other site 592029008026 Q-loop/lid; other site 592029008027 ABC transporter signature motif; other site 592029008028 Walker B; other site 592029008029 D-loop; other site 592029008030 H-loop/switch region; other site 592029008031 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 592029008032 active site 592029008033 catalytic triad [active] 592029008034 oxyanion hole [active] 592029008035 switch loop; other site 592029008036 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 592029008037 Asp-box motif; other site 592029008038 PLC-beta C terminal; Region: PLC-beta_C; pfam08703 592029008039 isocitrate dehydrogenase; Validated; Region: PRK09222 592029008040 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 592029008041 RNA polymerase sigma factor; Provisional; Region: PRK12513 592029008042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592029008043 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592029008044 DNA binding residues [nucleotide binding] 592029008045 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 592029008046 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592029008047 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592029008048 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 592029008049 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 592029008050 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 592029008051 oligomer interface [polypeptide binding]; other site 592029008052 metal binding site [ion binding]; metal-binding site 592029008053 metal binding site [ion binding]; metal-binding site 592029008054 Cl binding site [ion binding]; other site 592029008055 aspartate ring; other site 592029008056 basic sphincter; other site 592029008057 putative hydrophobic gate; other site 592029008058 periplasmic entrance; other site 592029008059 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 592029008060 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 592029008061 FOG: PKD repeat [General function prediction only]; Region: COG3291 592029008062 PKD domain; Region: PKD; pfam00801 592029008063 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 592029008064 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 592029008065 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 592029008066 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 592029008067 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 592029008068 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592029008069 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592029008070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592029008071 catalytic residue [active] 592029008072 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592029008073 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592029008074 dimer interface [polypeptide binding]; other site 592029008075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029008076 catalytic residue [active] 592029008077 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 592029008078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592029008079 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 592029008080 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 592029008081 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 592029008082 Lamin Tail Domain; Region: LTD; pfam00932 592029008083 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029008084 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 592029008085 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029008086 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 592029008087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592029008088 hypothetical protein; Provisional; Region: PRK12378 592029008089 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029008090 ligand binding site [chemical binding]; other site 592029008091 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 592029008092 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 592029008093 Probable Catalytic site; other site 592029008094 metal-binding site 592029008095 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 592029008096 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 592029008097 DNA polymerase III, delta subunit; Region: holA; TIGR01128 592029008098 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 592029008099 UbiA prenyltransferase family; Region: UbiA; pfam01040 592029008100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592029008101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592029008102 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 592029008103 dimerization interface [polypeptide binding]; other site 592029008104 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592029008105 Cytochrome c; Region: Cytochrom_C; pfam00034 592029008106 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 592029008107 dimer interface [polypeptide binding]; other site 592029008108 catalytic triad [active] 592029008109 peroxidatic and resolving cysteines [active] 592029008110 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 592029008111 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 592029008112 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 592029008113 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 592029008114 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 592029008115 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 592029008116 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 592029008117 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 592029008118 Predicted permeases [General function prediction only]; Region: COG0795 592029008119 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 592029008120 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 592029008121 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 592029008122 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 592029008123 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 592029008124 dimerization interface [polypeptide binding]; other site 592029008125 active site 592029008126 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 592029008127 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 592029008128 putative active site [active] 592029008129 OstA-like protein; Region: OstA_2; pfam13100 592029008130 OstA-like protein; Region: OstA; cl00844 592029008131 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 592029008132 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592029008133 inhibitor-cofactor binding pocket; inhibition site 592029008134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029008135 catalytic residue [active] 592029008136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029008137 binding surface 592029008138 TPR motif; other site 592029008139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 592029008140 TPR repeat; Region: TPR_11; pfam13414 592029008141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029008142 binding surface 592029008143 TPR motif; other site 592029008144 TPR repeat; Region: TPR_11; pfam13414 592029008145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029008146 binding surface 592029008147 TPR motif; other site 592029008148 TPR repeat; Region: TPR_11; pfam13414 592029008149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029008150 binding surface 592029008151 TPR repeat; Region: TPR_11; pfam13414 592029008152 TPR motif; other site 592029008153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592029008154 binding surface 592029008155 TPR motif; other site 592029008156 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 592029008157 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 592029008158 Chain length determinant protein; Region: Wzz; pfam02706 592029008159 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 592029008160 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592029008161 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 592029008162 SLBB domain; Region: SLBB; pfam10531 592029008163 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 592029008164 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 592029008165 NAD(P) binding site [chemical binding]; other site 592029008166 homodimer interface [polypeptide binding]; other site 592029008167 substrate binding site [chemical binding]; other site 592029008168 active site 592029008169 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029008170 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 592029008171 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592029008172 inhibitor-cofactor binding pocket; inhibition site 592029008173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029008174 catalytic residue [active] 592029008175 Bacterial sugar transferase; Region: Bac_transf; cl00939 592029008176 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 592029008177 active site 592029008178 cosubstrate binding site; other site 592029008179 substrate binding site [chemical binding]; other site 592029008180 catalytic site [active] 592029008181 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 592029008182 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592029008183 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 592029008184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029008185 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 592029008186 NAD(P) binding site [chemical binding]; other site 592029008187 active site 592029008188 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 592029008189 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 592029008190 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 592029008191 active site 592029008192 homodimer interface [polypeptide binding]; other site 592029008193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029008194 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 592029008195 NAD(P) binding site [chemical binding]; other site 592029008196 active site 592029008197 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 592029008198 WxcM-like, C-terminal; Region: FdtA; pfam05523 592029008199 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 592029008200 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 592029008201 NAD(P) binding site [chemical binding]; other site 592029008202 homodimer interface [polypeptide binding]; other site 592029008203 substrate binding site [chemical binding]; other site 592029008204 active site 592029008205 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 592029008206 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 592029008207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 592029008208 motif II; other site 592029008209 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 592029008210 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 592029008211 Ligand binding site; other site 592029008212 oligomer interface; other site 592029008213 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 592029008214 active site 592029008215 catalytic residues [active] 592029008216 metal binding site [ion binding]; metal-binding site 592029008217 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 592029008218 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 592029008219 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 592029008220 ligand binding site; other site 592029008221 tetramer interface; other site 592029008222 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 592029008223 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 592029008224 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 592029008225 Substrate binding site; other site 592029008226 metal-binding site 592029008227 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 592029008228 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 592029008229 active site 592029008230 homodimer interface [polypeptide binding]; other site 592029008231 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 592029008232 NeuB family; Region: NeuB; pfam03102 592029008233 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 592029008234 NeuB binding interface [polypeptide binding]; other site 592029008235 putative substrate binding site [chemical binding]; other site 592029008236 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 592029008237 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 592029008238 putative trimer interface [polypeptide binding]; other site 592029008239 putative CoA binding site [chemical binding]; other site 592029008240 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 592029008241 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592029008242 inhibitor-cofactor binding pocket; inhibition site 592029008243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592029008244 catalytic residue [active] 592029008245 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 592029008246 NAD(P) binding site [chemical binding]; other site 592029008247 homodimer interface [polypeptide binding]; other site 592029008248 substrate binding site [chemical binding]; other site 592029008249 active site 592029008250 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 592029008251 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592029008252 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 592029008253 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 592029008254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592029008255 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592029008256 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 592029008257 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 592029008258 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 592029008259 NAD binding site [chemical binding]; other site 592029008260 substrate binding site [chemical binding]; other site 592029008261 homodimer interface [polypeptide binding]; other site 592029008262 active site 592029008263 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 592029008264 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 592029008265 substrate binding site; other site 592029008266 tetramer interface; other site 592029008267 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 592029008268 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 592029008269 NAD binding site [chemical binding]; other site 592029008270 substrate binding site [chemical binding]; other site 592029008271 homodimer interface [polypeptide binding]; other site 592029008272 active site 592029008273 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 592029008274 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592029008275 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592029008276 ligand binding site [chemical binding]; other site 592029008277 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 592029008278 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 592029008279 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 592029008280 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 592029008281 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 592029008282 Ligand Binding Site [chemical binding]; other site 592029008283 TilS substrate C-terminal domain; Region: TilS_C; smart00977 592029008284 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 592029008285 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592029008286 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592029008287 Cna protein B-type domain; Region: Cna_B_2; pfam13715 592029008288 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592029008289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592029008290 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 592029008291 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 592029008292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029008293 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592029008294 PKD domain; Region: PKD; pfam00801 592029008295 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 592029008296 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 592029008297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592029008298 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 592029008299 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 592029008300 DNA binding residues [nucleotide binding] 592029008301 Gemmata obscuriglobus paralogous family TIGR03066; Region: Gem_osc_para_1 592029008302 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 592029008303 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 592029008304 metal ion-dependent adhesion site (MIDAS); other site 592029008305 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 592029008306 dimer interface [polypeptide binding]; other site 592029008307 substrate binding site [chemical binding]; other site 592029008308 metal binding sites [ion binding]; metal-binding site 592029008309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592029008310 Domain of unknown function (DUF389); Region: DUF389; pfam04087 592029008311 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 592029008312 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 592029008313 Substrate binding site; other site 592029008314 Domain of unknown function (DUF955); Region: DUF955; cl01076 592029008315 SprT-like family; Region: SprT-like; pfam10263 592029008316 SprT homologues; Region: SprT; cl01182 592029008317 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 592029008318 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 592029008319 Zn binding site [ion binding]; other site 592029008320 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 592029008321 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 592029008322 tetramer interface [polypeptide binding]; other site 592029008323 TPP-binding site [chemical binding]; other site 592029008324 heterodimer interface [polypeptide binding]; other site 592029008325 phosphorylation loop region [posttranslational modification] 592029008326 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 592029008327 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 592029008328 PYR/PP interface [polypeptide binding]; other site 592029008329 dimer interface [polypeptide binding]; other site 592029008330 TPP binding site [chemical binding]; other site 592029008331 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592029008332 Ion transport protein; Region: Ion_trans; pfam00520 592029008333 Ion channel; Region: Ion_trans_2; pfam07885 592029008334 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 592029008335 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 592029008336 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 592029008337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592029008338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592029008339 active site 592029008340 phosphorylation site [posttranslational modification] 592029008341 intermolecular recognition site; other site 592029008342 dimerization interface [polypeptide binding]; other site 592029008343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592029008344 DNA binding site [nucleotide binding] 592029008345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592029008346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592029008347 dimer interface [polypeptide binding]; other site 592029008348 phosphorylation site [posttranslational modification] 592029008349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592029008350 ATP binding site [chemical binding]; other site 592029008351 Mg2+ binding site [ion binding]; other site 592029008352 G-X-G motif; other site 592029008353 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 592029008354 dephospho-CoA kinase; Region: TIGR00152 592029008355 CoA-binding site [chemical binding]; other site 592029008356 ATP-binding [chemical binding]; other site 592029008357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592029008358 active site 592029008359 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008360 Interdomain contacts; other site 592029008361 Cytokine receptor motif; other site 592029008362 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008363 Interdomain contacts; other site 592029008364 Cytokine receptor motif; other site 592029008365 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 592029008366 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008367 Interdomain contacts; other site 592029008368 Cytokine receptor motif; other site 592029008369 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008370 Interdomain contacts; other site 592029008371 Cytokine receptor motif; other site 592029008372 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008373 Interdomain contacts; other site 592029008374 Cytokine receptor motif; other site 592029008375 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029008376 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008377 Interdomain contacts; other site 592029008378 Cytokine receptor motif; other site 592029008379 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 592029008380 heterodimerization interface [polypeptide binding]; other site 592029008381 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008382 Interdomain contacts; other site 592029008383 Cytokine receptor motif; other site 592029008384 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 592029008385 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 592029008386 Interdomain contacts; other site 592029008387 Cytokine receptor motif; other site 592029008388 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 592029008389 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 592029008390 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 592029008391 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 592029008392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592029008393 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 592029008394 NAD(P) binding site [chemical binding]; other site 592029008395 active site 592029008396 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 592029008397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592029008398 Walker A/P-loop; other site 592029008399 ATP binding site [chemical binding]; other site 592029008400 Q-loop/lid; other site 592029008401 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 592029008402 Q-loop/lid; other site 592029008403 ABC transporter signature motif; other site 592029008404 Walker B; other site 592029008405 D-loop; other site 592029008406 H-loop/switch region; other site 592029008407 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 592029008408 Flavoprotein; Region: Flavoprotein; pfam02441 592029008409 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 592029008410 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 592029008411 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 592029008412 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 592029008413 dihydrodipicolinate synthase; Region: dapA; TIGR00674 592029008414 dimer interface [polypeptide binding]; other site 592029008415 active site 592029008416 catalytic residue [active] 592029008417 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 592029008418 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 592029008419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592029008420 active site 592029008421 metal binding site [ion binding]; metal-binding site 592029008422 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 592029008423 GIY-YIG motif/motif A; other site 592029008424 putative active site [active] 592029008425 putative metal binding site [ion binding]; other site 592029008426 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 592029008427 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 592029008428 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 592029008429 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 592029008430 nucleotide binding pocket [chemical binding]; other site 592029008431 K-X-D-G motif; other site 592029008432 catalytic site [active] 592029008433 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 592029008434 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 592029008435 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 592029008436 Dimer interface [polypeptide binding]; other site 592029008437 BRCT sequence motif; other site 592029008438 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 592029008439 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 592029008440 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 592029008441 active site 592029008442 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 592029008443 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 592029008444 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 592029008445 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 592029008446 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 592029008447 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 592029008448 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 592029008449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592029008450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592029008451 Coenzyme A binding pocket [chemical binding]; other site 592029008452 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592029008453 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 592029008454 catalytic motif [active] 592029008455 Zn binding site [ion binding]; other site 592029008456 RibD C-terminal domain; Region: RibD_C; pfam01872 592029008457 Sugar transport protein; Region: Sugar_transport; pfam06800 592029008458 Uncharacterized conserved protein [Function unknown]; Region: COG1739 592029008459 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 592029008460 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 592029008461 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 592029008462 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 592029008463 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592029008464 active site