-- dump date 20140619_232001 -- class Genbank::misc_feature -- table misc_feature_note -- id note 218491000001 FMN-binding protein MioC; Provisional; Region: PRK09004 218491000002 HMMPfam hit to PF00258, DE Flavodoxin, score 4.4e-31 218491000003 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 218491000004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491000005 putative DNA binding site [nucleotide binding]; other site 218491000006 putative Zn2+ binding site [ion binding]; other site 218491000007 AsnC family; Region: AsnC_trans_reg; pfam01037 218491000008 HMMPfam hit to PF01037, DE AsnC family, score 2e-16 218491000009 Predicted helix-turn-helix motif with score 1710.000, SD 5.01 at aa 24-45, sequence TPYAELAKQFSVSPGTIHVRVE 218491000010 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 218491000011 motif 1; other site 218491000012 dimer interface [polypeptide binding]; other site 218491000013 active site 218491000014 motif 2; other site 218491000015 motif 3; other site 218491000016 HMMPfam hit to PF03590, DE Aspartate-ammonia ligase, score 2.8e-173 218491000017 hypothetical protein; Provisional; Region: yieM; PRK10997 218491000018 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 218491000019 metal ion-dependent adhesion site (MIDAS); other site 218491000020 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 215-236, sequence PALQKLAERLGRSRETKSILTQ 218491000021 regulatory ATPase RavA; Provisional; Region: PRK13531 218491000022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491000023 Walker A motif; other site 218491000024 ATP binding site [chemical binding]; other site 218491000025 Walker B motif; other site 218491000026 arginine finger; other site 218491000027 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 218491000028 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 218491000029 Signal peptide predicted for ECA0006 by SignalP 2.0 HMM (Signal peptide probabilty 0.892) with cleavage site probability 0.891 between residues 22 and 23; signal peptide 218491000030 potassium uptake protein; Region: kup; TIGR00794 218491000031 12 probable transmembrane helices predicted for ECA0006 by TMHMM2.0 at aa 7-29, 49-71, 102-124, 134-156, 168-190, 210-232, 245-267, 287-309, 334-356, 366-388, 395-417 and 422-440 218491000032 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02705, DE K+ potassium transporter, score 1e-291 218491000033 sensor protein QseC; Provisional; Region: PRK10337 218491000034 Signal peptide predicted for ECA0007 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.423 between residues 28 and 29; signal peptide 218491000035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218491000036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491000037 dimer interface [polypeptide binding]; other site 218491000038 phosphorylation site [posttranslational modification] 218491000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491000040 ATP binding site [chemical binding]; other site 218491000041 Mg2+ binding site [ion binding]; other site 218491000042 G-X-G motif; other site 218491000043 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 7.4e-23 218491000044 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 1.3e-14 218491000045 HMMPfam hit to PF00672, DE HAMP domain, score 2.5e-07 218491000046 2 probable transmembrane helices predicted for ECA0007 by TMHMM2.0 at aa 10-32 and 164-183 218491000047 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 218491000048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491000049 active site 218491000050 phosphorylation site [posttranslational modification] 218491000051 intermolecular recognition site; other site 218491000052 dimerization interface [polypeptide binding]; other site 218491000053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491000054 DNA binding site [nucleotide binding] 218491000055 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 8.1e-26 218491000056 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.6e-34 218491000057 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 218491000058 Signal peptide predicted for ECA0009 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21; signal peptide 218491000059 D-ribose pyranase; Provisional; Region: PRK11797 218491000060 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 218491000061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491000062 Walker A/P-loop; other site 218491000063 ATP binding site [chemical binding]; other site 218491000064 Q-loop/lid; other site 218491000065 ABC transporter signature motif; other site 218491000066 Walker B; other site 218491000067 D-loop; other site 218491000068 H-loop/switch region; other site 218491000069 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491000070 HMMPfam hit to PF00005, DE ABC transporter, score 3.7e-50 218491000071 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000072 HMMPfam hit to PF00005, DE ABC transporter, score 2.5e-35 218491000073 PS00211 ABC transporters family signature. 218491000074 Signal peptide predicted for ECA0012 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.303 between residues 35 and 36; signal peptide 218491000075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491000076 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491000077 TM-ABC transporter signature motif; other site 218491000078 7 probable transmembrane helices predicted for ECA0012 by TMHMM2.0 at aa 22-44, 65-87, 97-119, 126-148, 168-190, 221-243 and 275-297 218491000079 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 3.6e-05 218491000080 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 218491000081 Signal peptide predicted for ECA0013 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.931 between residues 25 and 26; signal peptide 218491000082 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 218491000083 ligand binding site [chemical binding]; other site 218491000084 dimerization interface [polypeptide binding]; other site 218491000085 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 2.4e-14 218491000086 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000087 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218491000088 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 218491000089 substrate binding site [chemical binding]; other site 218491000090 dimer interface [polypeptide binding]; other site 218491000091 ATP binding site [chemical binding]; other site 218491000092 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 3.2e-83 218491000093 PS00583 pfkB family of carbohydrate kinases signature 1. 218491000094 PS00584 pfkB family of carbohydrate kinases signature 2. 218491000095 transcriptional repressor RbsR; Provisional; Region: PRK10423 218491000096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491000097 DNA binding site [nucleotide binding] 218491000098 domain linker motif; other site 218491000099 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 218491000100 dimerization interface [polypeptide binding]; other site 218491000101 ligand binding site [chemical binding]; other site 218491000102 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 1.8e-12 218491000103 Predicted helix-turn-helix motif with score 2156.000, SD 6.53 at aa 2-23, sequence ATMKDVARLAGVSTSTVSHVIN 218491000104 PS00356 Bacterial regulatory proteins, lacI family signature. 218491000105 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 9.5e-24 218491000106 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 218491000107 Walker A motif; other site 218491000108 HMMPfam hit to PF03205, DE Molybdopterin guanine dinucleotide synthesis protein B, score 1.1e-53 218491000109 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000110 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 218491000111 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 218491000112 GTP binding site; other site 218491000113 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 218491000114 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 218491000115 serine/threonine protein kinase; Provisional; Region: PRK11768 218491000116 Signal peptide predicted for ECA0020 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 19 and 20; signal peptide 218491000117 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 218491000118 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 218491000119 catalytic residues [active] 218491000120 hinge region; other site 218491000121 alpha helical domain; other site 218491000122 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01323, DE DSBA-like thioredoxin domain, score 1.8e-146 218491000123 PS00194 Thioredoxin family active site. 218491000124 DNA polymerase I; Provisional; Region: PRK05755 218491000125 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218491000126 active site 218491000127 metal binding site 1 [ion binding]; metal-binding site 218491000128 putative 5' ssDNA interaction site; other site 218491000129 metal binding site 3; metal-binding site 218491000130 metal binding site 2 [ion binding]; metal-binding site 218491000131 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218491000132 putative DNA binding site [nucleotide binding]; other site 218491000133 putative metal binding site [ion binding]; other site 218491000134 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 218491000135 active site 218491000136 catalytic site [active] 218491000137 substrate binding site [chemical binding]; other site 218491000138 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 218491000139 active site 218491000140 DNA binding site [nucleotide binding] 218491000141 catalytic site [active] 218491000142 HMMPfam hit to PF02739, DE 5'-3' exonuclease, N-terminal resolvase-like domain, score 9.6e-89 218491000143 HMMPfam hit to PF01367, DE 5'-3' exonuclease, C-terminal SAM fold, score 1.3e-53 218491000144 HMMPfam hit to PF01612, DE 3'-5' exonuclease, score 1.7e-62 218491000145 HMMPfam hit to PF00476, DE DNA polymerase family A, score 1.2e-211 218491000146 PS00447 DNA polymerase family A signature. 218491000147 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 218491000148 G1 box; other site 218491000149 GTP/Mg2+ binding site [chemical binding]; other site 218491000150 Switch I region; other site 218491000151 G2 box; other site 218491000152 G3 box; other site 218491000153 Switch II region; other site 218491000154 G4 box; other site 218491000155 G5 box; other site 218491000156 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000157 Der GTPase activator; Provisional; Region: PRK05244 218491000158 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 218491000159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491000160 FeS/SAM binding site; other site 218491000161 HemN C-terminal domain; Region: HemN_C; pfam06969 218491000162 HMMPfam hit to PF02473, , score 7.7e-160 218491000163 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 218491000164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491000165 active site 218491000166 phosphorylation site [posttranslational modification] 218491000167 intermolecular recognition site; other site 218491000168 dimerization interface [polypeptide binding]; other site 218491000169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491000170 Walker A motif; other site 218491000171 ATP binding site [chemical binding]; other site 218491000172 Walker B motif; other site 218491000173 arginine finger; other site 218491000174 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218491000175 HMMPfam hit to PF02954, DE Bacterial regulatory protein, Fis family, score 3e-15 218491000176 Predicted helix-turn-helix motif with score 1763.000, SD 5.19 at aa 444-465, sequence GHKQEAARLLGWGRNTLTRKLK 218491000177 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491000178 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 5.6e-144 218491000179 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491000180 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491000181 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 6e-38 218491000182 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 218491000183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491000184 dimer interface [polypeptide binding]; other site 218491000185 phosphorylation site [posttranslational modification] 218491000186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491000187 ATP binding site [chemical binding]; other site 218491000188 Mg2+ binding site [ion binding]; other site 218491000189 G-X-G motif; other site 218491000190 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.4e-28 218491000191 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 2.5e-14 218491000192 glutamine synthetase; Provisional; Region: glnA; PRK09469 218491000193 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 218491000194 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 218491000195 PS00182 Glutamine synthetase class-I adenylation site. 218491000196 HMMPfam hit to PF00120, DE Glutamine synthetase, catalytic domain, score 1.2e-166 218491000197 PS00181 Glutamine synthetase ATP-binding region signature. 218491000198 HMMPfam hit to PF03951, DE Glutamine synthetase, beta-Grasp domain, score 7.9e-47 218491000199 PS00180 Glutamine synthetase signature 1. 218491000200 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 218491000201 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 218491000202 G1 box; other site 218491000203 putative GEF interaction site [polypeptide binding]; other site 218491000204 GTP/Mg2+ binding site [chemical binding]; other site 218491000205 Switch I region; other site 218491000206 G2 box; other site 218491000207 G3 box; other site 218491000208 Switch II region; other site 218491000209 G4 box; other site 218491000210 G5 box; other site 218491000211 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 218491000212 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 218491000213 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 2.5e-73 218491000214 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000215 PS00301 GTP-binding elongation factors signature. 218491000216 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 5.9e-16 218491000217 HMMPfam hit to PF00679, DE Elongation factor G C-terminus, score 1.6e-28 218491000218 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 218491000219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491000220 motif II; other site 218491000221 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 2.8e-14 218491000222 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 218491000223 putative active site [active] 218491000224 dimerization interface [polypeptide binding]; other site 218491000225 putative tRNAtyr binding site [nucleotide binding]; other site 218491000226 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02580, DE D-Tyr-tRNA(Tyr) deacylase, score 2.5e-71 218491000227 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218491000228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491000229 Coenzyme A binding pocket [chemical binding]; other site 218491000230 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 218491000231 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 3.4e-16 218491000232 AsmA family; Region: AsmA; pfam05170 218491000233 Signal peptide predicted for ECA0034 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.912 between residues 31 and 32; signal peptide 218491000234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 218491000235 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 218491000236 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 218491000237 11 probable transmembrane helices predicted for ECA0035 by TMHMM2.0 at aa 42-64, 94-116, 126-148, 155-177, 192-211, 218-240, 260-282, 345-367, 377-399, 406-428 and 438-457 218491000238 HMMPfam hit to PF00860, DE Permease family, score 1.6e-151 218491000239 PS01116 Xanthine/uracil permeases family signature. 218491000240 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491000241 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 218491000242 Y-family of DNA polymerases; Region: PolY; cl12025 218491000243 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 218491000244 generic binding surface II; other site 218491000245 ssDNA binding site; other site 218491000246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491000247 ATP binding site [chemical binding]; other site 218491000248 putative Mg++ binding site [ion binding]; other site 218491000249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491000250 nucleotide binding region [chemical binding]; other site 218491000251 ATP-binding site [chemical binding]; other site 218491000252 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 8.3e-22 218491000253 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 1.4e-31 218491000254 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000255 HMMPfam hit to PF01336, DE OB-fold nucleic acid binding domain, score 2e-07 218491000256 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 218491000257 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218491000258 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 218491000259 HMMPfam hit to PF00588, DE SpoU rRNA Methylase family, score 6.2e-56 218491000260 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 218491000261 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218491000262 Zn2+ binding site [ion binding]; other site 218491000263 Mg2+ binding site [ion binding]; other site 218491000264 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218491000265 synthetase active site [active] 218491000266 NTP binding site [chemical binding]; other site 218491000267 metal binding site [ion binding]; metal-binding site 218491000268 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 218491000269 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 218491000270 HMMPfam hit to PF01842, DE ACT domain, score 0.046 218491000271 HMMPfam hit to PF02824, DE TGS domain, score 1.4e-26 218491000272 HMMPfam hit to PF01966, DE HD domain, score 2.6e-18 218491000273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491000274 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 218491000275 HMMPfam hit to PF01192, DE RNA polymerase Rpb6, score 1.8e-21 218491000276 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 218491000277 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 218491000278 catalytic site [active] 218491000279 G-X2-G-X-G-K; other site 218491000280 HMMPfam hit to PF00625, DE Guanylate kinase, score 7.2e-56 218491000281 PS00856 Guanylate kinase signature. 218491000282 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000283 2 probable transmembrane helices predicted for ECA0041 by TMHMM2.0 at aa 15-37 and 50-67 218491000284 Signal peptide predicted for ECA0043 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.981 between residues 24 and 25; signal peptide 218491000285 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 218491000286 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 218491000287 nucleotide binding pocket [chemical binding]; other site 218491000288 K-X-D-G motif; other site 218491000289 catalytic site [active] 218491000290 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218491000291 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218491000292 HMMPfam hit to PF01653, DE NAD-dependent DNA ligase adenylation domain, score 3.3e-53 218491000293 PS01055 NAD-dependent DNA ligase signature 1. 218491000294 HMMPfam hit to PF03120, DE NAD-dependent DNA ligase OB-fold domain, score 3.1e-19 218491000295 phosphoethanolamine transferase; Provisional; Region: PRK11560 218491000296 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 218491000297 Sulfatase; Region: Sulfatase; pfam00884 218491000298 HMMPfam hit to PF02418, , score 3.9e-145 218491000299 5 probable transmembrane helices predicted for ECA0044 by TMHMM2.0 at aa 12-33, 48-70, 83-105, 120-139 and 160-177 218491000300 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000301 Signal peptide predicted for ECA0045 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.576 between residues 23 and 24; signal peptide 218491000302 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 218491000303 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00695 Enterobacterial virulence outer membrane protein signature 2. 218491000304 Signal peptide predicted for ECA0046 by SignalP 2.0 HMM (Signal peptide probabilty 0.811) with cleavage site probability 0.480 between residues 33 and 34; signal peptide 218491000305 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 218491000306 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218491000307 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491000308 HMMPfam hit to PF00563, DE EAL domain, score 1.3e-86 218491000309 2 probable transmembrane helices predicted for ECA0046 by TMHMM2.0 at aa 11-33 and 240-262 218491000310 Predicted flavoproteins [General function prediction only]; Region: COG2081 218491000311 Signal peptide predicted for ECA0047 by SignalP 2.0 HMM (Signal peptide probabilty 0.842) with cleavage site probability 0.721 between residues 22 and 23; signal peptide 218491000312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491000313 HMMPfam hit to PF03486, DE HI0933-like protein, score 3e-186 218491000314 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 218491000315 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 218491000316 10 probable transmembrane helices predicted for ECA0048 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-145, 155-177, 207-224, 234-256, 383-404, 419-441 and 476-498 218491000317 HMMPfam hit to PF01384, DE Phosphate transporter family, score 3.9e-93 218491000318 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000319 universal stress protein UspB; Provisional; Region: PRK04960 218491000320 2 probable transmembrane helices predicted for ECA0049 by TMHMM2.0 at aa 5-24 and 88-110 218491000321 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218491000322 Ligand Binding Site [chemical binding]; other site 218491000323 HMMPfam hit to PF00582, DE Universal stress protein family, score 6.6e-56 218491000324 glutamate dehydrogenase; Provisional; Region: PRK09414 218491000325 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 218491000326 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 218491000327 NAD(P) binding site [chemical binding]; other site 218491000328 HMMPfam hit to PF02812, DE Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 1.9e-78 218491000329 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 218491000330 HMMPfam hit to PF00208, DE Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 2.3e-121 218491000331 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 218491000332 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 218491000333 Signal peptide predicted for ECA0053 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 18 and 19; signal peptide 218491000334 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 218491000335 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 218491000336 active site 218491000337 metal binding site [ion binding]; metal-binding site 218491000338 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218491000339 HMMPfam hit to PF02872, DE 5'-nucleotidase, C-terminal domain, score 6.5e-32 218491000340 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 1.1e-15 218491000341 PS00786 5'-nucleotidase signature 2. 218491000342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491000343 S-adenosylmethionine binding site [chemical binding]; other site 218491000344 oligopeptidase A; Provisional; Region: PRK10911 218491000345 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 218491000346 active site 218491000347 Zn binding site [ion binding]; other site 218491000348 HMMPfam hit to PF01432, DE Peptidase family M3, score 2.9e-231 218491000349 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491000350 Signal peptide predicted for ECA0056 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.928 between residues 43 and 44; signal peptide 218491000351 Secretin and TonB N terminus short domain; Region: STN; smart00965 218491000352 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 218491000353 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491000354 N-terminal plug; other site 218491000355 ligand-binding site [chemical binding]; other site 218491000356 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 2e-17 218491000357 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491000358 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 218491000359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491000360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491000361 DNA binding residues [nucleotide binding] 218491000362 HMMPfam hit to PF00776, , score 0.00043 218491000363 PS01063 Sigma-70 factors ECF subfamily signature. 218491000364 Predicted helix-turn-helix motif with score 1671.000, SD 4.88 at aa 137-158, sequence MRYSDIAERLRVSSSSVKQYLQ 218491000365 fec operon regulator FecR; Reviewed; Region: PRK09774 218491000366 FecR protein; Region: FecR; pfam04773 218491000367 PS00904 Protein prenyltransferases alpha subunit repeat signature. 218491000368 Signal peptide predicted for ECA0059 by SignalP 2.0 HMM (Signal peptide probabilty 0.633) with cleavage site probability 0.479 between residues 31 and 32; signal peptide 218491000369 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 218491000370 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 218491000371 1 probable transmembrane helix predicted for ECA0059 by TMHMM2.0 at aa 20-42 218491000372 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 218491000373 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 218491000374 PS00092 N-6 Adenine-specific DNA methylases signature. 218491000375 PS00092 N-6 Adenine-specific DNA methylases signature. 218491000376 glutathione reductase; Validated; Region: PRK06116 218491000377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491000378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491000379 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218491000380 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 4.5e-83 218491000381 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218491000382 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02852, DE Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 1e-52 218491000383 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 218491000384 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 218491000385 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 218491000386 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 218491000387 FAD binding pocket [chemical binding]; other site 218491000388 FAD binding motif [chemical binding]; other site 218491000389 phosphate binding motif [ion binding]; other site 218491000390 NAD binding pocket [chemical binding]; other site 218491000391 Signal peptide predicted for ECA0066 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 20 and 21; signal peptide 218491000392 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 218491000393 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 218491000394 dimerization domain [polypeptide binding]; other site 218491000395 dimer interface [polypeptide binding]; other site 218491000396 catalytic residues [active] 218491000397 Signal peptide predicted for ECA0067 by SignalP 2.0 HMM (Signal peptide probabilty 0.622) with cleavage site probability 0.477 between residues 26 and 27; signal peptide 218491000398 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 218491000399 6 probable transmembrane helices predicted for ECA0067 by TMHMM2.0 at aa 7-29, 44-66, 71-93, 113-135, 144-166 and 186-205 218491000400 HMMPfam hit to PF01810, DE LysE type translocator, score 8.3e-10 218491000401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491000402 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 218491000403 LysR substrate binding domain; Region: LysR_substrate; pfam03466 218491000404 dimerization interface [polypeptide binding]; other site 218491000405 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.9e-15 218491000406 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 6.4e-17 218491000407 Predicted helix-turn-helix motif with score 1394.000, SD 3.93 at aa 14-35, sequence GGYTQAANVLHRSQSSVSYQLS 218491000408 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 218491000409 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 218491000410 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 218491000411 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 218491000412 PS00019 Actinin-type actin-binding domain signature 1. 218491000413 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 218491000414 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 218491000415 HMMPfam hit to PF00296, DE Luciferase-like monooxygenase, score 1.5e-23 218491000416 Signal peptide predicted for ECA0072 by SignalP 2.0 HMM (Signal peptide probabilty 0.621) with cleavage site probability 0.582 between residues 17 and 18; signal peptide 218491000417 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218491000418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491000419 Walker A/P-loop; other site 218491000420 ATP binding site [chemical binding]; other site 218491000421 Q-loop/lid; other site 218491000422 ABC transporter signature motif; other site 218491000423 Walker B; other site 218491000424 D-loop; other site 218491000425 H-loop/switch region; other site 218491000426 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491000427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491000428 Walker A/P-loop; other site 218491000429 ATP binding site [chemical binding]; other site 218491000430 Q-loop/lid; other site 218491000431 ABC transporter signature motif; other site 218491000432 Walker B; other site 218491000433 D-loop; other site 218491000434 H-loop/switch region; other site 218491000435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491000436 HMMPfam hit to PF00005, DE ABC transporter, score 1.9e-59 218491000437 PS00211 ABC transporters family signature. 218491000438 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000439 HMMPfam hit to PF00005, DE ABC transporter, score 5.4e-59 218491000440 PS00211 ABC transporters family signature. 218491000441 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000442 Signal peptide predicted for ECA0073 by SignalP 2.0 HMM (Signal peptide probabilty 0.802) with cleavage site probability 0.626 between residues 43 and 44; signal peptide 218491000443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218491000444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491000445 putative PBP binding loops; other site 218491000446 dimer interface [polypeptide binding]; other site 218491000447 ABC-ATPase subunit interface; other site 218491000448 6 probable transmembrane helices predicted for ECA0073 by TMHMM2.0 at aa 23-45, 96-118, 131-153, 186-203, 210-232 and 252-274 218491000449 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 6.5e-11 218491000450 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491000451 Signal peptide predicted for ECA0074 by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.603 between residues 29 and 30; signal peptide 218491000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491000453 dimer interface [polypeptide binding]; other site 218491000454 conserved gate region; other site 218491000455 putative PBP binding loops; other site 218491000456 ABC-ATPase subunit interface; other site 218491000457 6 probable transmembrane helices predicted for ECA0074 by TMHMM2.0 at aa 13-32, 103-125, 138-160, 175-195, 234-256 and 276-298 218491000458 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0023 218491000459 Signal peptide predicted for ECA0075 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 28 and 29; signal peptide 218491000460 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491000461 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 218491000462 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 6.4e-20 218491000463 Signal peptide predicted for ECA0077 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.565 between residues 24 and 25; signal peptide 218491000464 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 218491000465 Beta-lactamase; Region: Beta-lactamase; pfam00144 218491000466 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491000467 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 218491000468 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 218491000469 dimerization interface [polypeptide binding]; other site 218491000470 ligand binding site [chemical binding]; other site 218491000471 NADP binding site [chemical binding]; other site 218491000472 catalytic site [active] 218491000473 HMMPfam hit to PF02826, DE D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 4.4e-81 218491000474 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 218491000475 HMMPfam hit to PF00389, DE D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 6.7e-17 218491000476 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491000477 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491000478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491000479 dimerization interface [polypeptide binding]; other site 218491000480 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491000481 dimer interface [polypeptide binding]; other site 218491000482 putative CheW interface [polypeptide binding]; other site 218491000483 2 probable transmembrane helices predicted for ECA0080 by TMHMM2.0 at aa 28-50 and 292-314 218491000484 HMMPfam hit to PF00672, DE HAMP domain, score 3.6e-08 218491000485 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 5.6e-105 218491000486 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218491000487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491000488 Coenzyme A binding pocket [chemical binding]; other site 218491000489 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 8.2e-13 218491000490 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 218491000491 HMMPfam hit to PF03352, DE Methyladenine glycosylase, score 1.4e-121 218491000492 Signal peptide predicted for ECA0083 by SignalP 2.0 HMM (Signal peptide probabilty 0.849) with cleavage site probability 0.474 between residues 38 and 39; signal peptide 218491000493 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 218491000494 7 probable transmembrane helices predicted for ECA0083 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 107-126, 139-161, 176-198 and 210-232 218491000495 HMMPfam hit to PF01925, DE Domain of unknown function DUF81, score 3e-06 218491000496 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 218491000497 dimer interface [polypeptide binding]; other site 218491000498 motif 1; other site 218491000499 active site 218491000500 motif 2; other site 218491000501 motif 3; other site 218491000502 HMMPfam hit to PF02091, DE Glycyl-tRNA synthetase alpha subunit, score 1.3e-247 218491000503 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491000504 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 218491000505 DALR anticodon binding domain; Region: DALR_1; pfam05746 218491000506 HMMPfam hit to PF02092, DE Glycyl-tRNA synthetase beta subunit, score 0 218491000507 Signal peptide predicted for ECA0086 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.747 between residues 22 and 23; signal peptide 218491000508 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 218491000509 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 218491000510 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 218491000511 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 218491000512 active site 218491000513 P-loop; other site 218491000514 phosphorylation site [posttranslational modification] 218491000515 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218491000516 active site 218491000517 phosphorylation site [posttranslational modification] 218491000518 8 probable transmembrane helices predicted for ECA0087 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 137-159, 214-236, 246-265, 270-292 and 312-334 218491000519 HMMPfam hit to PF00359, DE Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 2.4e-79 218491000520 PS00372 PTS EIIA domains phosphorylation site signature 2. 218491000521 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 218491000522 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218491000523 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218491000524 HMMPfam hit to PF01232, DE Mannitol dehydrogenase, score 1.4e-152 218491000525 PS00974 Mannitol dehydrogenases signature. 218491000526 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 218491000527 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 218491000528 hypothetical protein; Provisional; Region: PRK11020 218491000529 Signal peptide predicted for ECA0091 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.748 between residues 29 and 30; signal peptide 218491000530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491000531 dimerization interface [polypeptide binding]; other site 218491000532 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491000533 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491000534 dimer interface [polypeptide binding]; other site 218491000535 putative CheW interface [polypeptide binding]; other site 218491000536 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 7.8e-111 218491000537 PS00538 Bacterial chemotaxis sensory transducers signature. 218491000538 HMMPfam hit to PF00672, DE HAMP domain, score 1.9e-09 218491000539 2 probable transmembrane helices predicted for ECA0091 by TMHMM2.0 at aa 15-37 and 280-302 218491000540 superoxide dismutase; Provisional; Region: PRK10925 218491000541 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 218491000542 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 218491000543 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02777, DE Iron/manganese superoxide dismutases, C-terminal domain, score 1.5e-65 218491000544 PS00088 Manganese and iron superoxide dismutases signature. 218491000545 HMMPfam hit to PF00081, DE Iron/manganese superoxide dismutases, alpha-hairpin domain, score 3.3e-22 218491000546 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 218491000547 HMMPfam hit to PF02634, DE FdhD/NarQ family, score 2e-123 218491000548 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 218491000549 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 218491000550 NAD(P) binding site [chemical binding]; other site 218491000551 catalytic residues [active] 218491000552 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 5.3e-229 218491000553 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491000554 PS00070 Aldehyde dehydrogenases cysteine active site. 218491000555 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 218491000556 Acyltransferase family; Region: Acyl_transf_3; pfam01757 218491000557 10 probable transmembrane helices predicted for ECA0095 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 114-136, 143-160, 170-189, 202-221, 231-253, 262-284 and 299-321 218491000558 xylulokinase; Provisional; Region: PRK15027 218491000559 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 218491000560 N- and C-terminal domain interface [polypeptide binding]; other site 218491000561 active site 218491000562 MgATP binding site [chemical binding]; other site 218491000563 catalytic site [active] 218491000564 metal binding site [ion binding]; metal-binding site 218491000565 xylulose binding site [chemical binding]; other site 218491000566 homodimer interface [polypeptide binding]; other site 218491000567 HMMPfam hit to PF02782, DE FGGY family of carbohydrate kinases, C-terminal domain, score 2.7e-82 218491000568 PS00445 FGGY family of carbohydrate kinases signature 2. 218491000569 HMMPfam hit to PF00370, DE FGGY family of carbohydrate kinases, N-terminal domain, score 2.4e-118 218491000570 PS00933 FGGY family of carbohydrate kinases signature 1. 218491000571 xylose isomerase; Provisional; Region: PRK05474 218491000572 xylose isomerase; Region: xylose_isom_A; TIGR02630 218491000573 HMMPfam hit to PF00259, DE Xylose isomerase, score 3.6e-259 218491000574 PS00172 Xylose isomerase signature 1. 218491000575 PS00173 Xylose isomerase signature 2. 218491000576 Signal peptide predicted for ECA0098 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 24 and 25; signal peptide 218491000577 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 218491000578 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 218491000579 putative ligand binding site [chemical binding]; other site 218491000580 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491000581 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 2.8e-05 218491000582 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 218491000583 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491000584 Walker A/P-loop; other site 218491000585 ATP binding site [chemical binding]; other site 218491000586 Q-loop/lid; other site 218491000587 ABC transporter signature motif; other site 218491000588 Walker B; other site 218491000589 D-loop; other site 218491000590 H-loop/switch region; other site 218491000591 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491000592 HMMPfam hit to PF00005, DE ABC transporter, score 6.3e-44 218491000593 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000594 HMMPfam hit to PF00005, DE ABC transporter, score 6.6e-24 218491000595 PS00211 ABC transporters family signature. 218491000596 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491000597 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491000598 TM-ABC transporter signature motif; other site 218491000599 10 probable transmembrane helices predicted for ECA0100 by TMHMM2.0 at aa 24-46, 61-80, 85-107, 111-133, 140-162, 177-196, 243-265, 291-313, 326-348 and 368-385 218491000600 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 0.00031 218491000601 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 218491000602 putative dimerization interface [polypeptide binding]; other site 218491000603 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491000604 putative ligand binding site [chemical binding]; other site 218491000605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491000606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491000607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491000608 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.41 218491000609 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.5e-05 218491000610 Predicted helix-turn-helix motif with score 1108.000, SD 2.96 at aa 303-324, sequence IKVEQVLDAVGISRSNLEKRFK 218491000611 PS00041 Bacterial regulatory proteins, araC family signature. 218491000612 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 4.1e-11 218491000613 DJ-1 family protein; Region: not_thiJ; TIGR01383 218491000614 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 218491000615 conserved cys residue [active] 218491000616 HMMPfam hit to PF01965, DE DJ-1/PfpI family, score 1.1e-23 218491000617 argininosuccinate synthase; Validated; Region: PRK05370 218491000618 HMMPfam hit to PF00764, DE Arginosuccinate synthase, score 8.6e-209 218491000619 PS00564 Argininosuccinate synthase signature 1. 218491000620 PS00565 Argininosuccinate synthase signature 2. 218491000621 Autoinducer synthetase; Region: Autoind_synth; pfam00765 218491000622 HMMPfam hit to PF00765, DE Autoinducer synthetase, score 1.7e-132 218491000623 PS00949 Autoinducers synthetases family signature. 218491000624 Autoinducer binding domain; Region: Autoind_bind; pfam03472 218491000625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491000626 DNA binding residues [nucleotide binding] 218491000627 dimerization interface [polypeptide binding]; other site 218491000628 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 1.7e-08 218491000629 PS00622 Bacterial regulatory proteins, luxR family signature. 218491000630 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 150-171, sequence KTYLEVAIILGIKTSTVKFHIG 218491000631 HMMPfam hit to PF03472, DE Autoinducer binding domain, score 4.2e-30 218491000632 acyl-CoA thioesterase; Provisional; Region: PRK10531 218491000633 putative pectinesterase; Region: PLN02432; cl01911 218491000634 HMMPfam hit to PF01095, DE Pectinesterase, score 8.8e-11 218491000635 PS00503 Pectinesterase signature 2. 218491000636 GlpM protein; Region: GlpM; pfam06942 218491000637 5 probable transmembrane helices predicted for ECA0108 by TMHMM2.0 at aa 7-24, 34-56, 61-83, 93-115 and 124-146 218491000638 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 218491000639 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 218491000640 dimer interface [polypeptide binding]; other site 218491000641 active site 218491000642 CoA binding pocket [chemical binding]; other site 218491000643 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218491000644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491000645 NAD(P) binding site [chemical binding]; other site 218491000646 active site 218491000647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218491000648 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 218491000649 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 218491000650 Signal peptide predicted for ECA0113 by SignalP 2.0 HMM (Signal peptide probabilty 0.679) with cleavage site probability 0.393 between residues 30 and 31; signal peptide 218491000651 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 218491000652 active site 218491000653 6 probable transmembrane helices predicted for ECA0113 by TMHMM2.0 at aa 13-35, 55-74, 87-109, 124-146, 155-172 and 176-195 218491000654 HMMPfam hit to PF01569, DE PAP2 superfamily, score 0.017 218491000655 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 218491000656 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 218491000657 8 probable transmembrane helices predicted for ECA0114 by TMHMM2.0 at aa 7-26, 46-68, 75-92, 134-156, 260-282, 292-311, 318-337 and 341-363 218491000658 Fatty acid desaturase; Region: FA_desaturase; pfam00487 218491000659 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 218491000660 putative di-iron ligands [ion binding]; other site 218491000661 5 probable transmembrane helices predicted for ECA0115 by TMHMM2.0 at aa 46-65, 69-91, 168-185, 209-231 and 238-260 218491000662 HMMPfam hit to PF00487, DE Fatty acid desaturase, score 1.1e-05 218491000663 Fatty acid desaturase; Region: FA_desaturase; pfam00487 218491000664 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 218491000665 putative di-iron ligands [ion binding]; other site 218491000666 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 218491000667 5 probable transmembrane helices predicted for ECA0116 by TMHMM2.0 at aa 38-60, 67-89, 166-185, 206-228 and 238-260 218491000668 HMMPfam hit to PF00487, DE Fatty acid desaturase, score 1.2e-06 218491000669 Signal peptide predicted for ECA0117 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 21 and 22; signal peptide 218491000670 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 218491000671 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 218491000672 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 218491000673 NAD binding site [chemical binding]; other site 218491000674 catalytic residues [active] 218491000675 substrate binding site [chemical binding]; other site 218491000676 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 6.4e-214 218491000677 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491000678 PS00070 Aldehyde dehydrogenases cysteine active site. 218491000679 HMMPfam hit to PF01468, DE GA module, score 1.2 218491000680 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 218491000681 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 218491000682 active site 218491000683 substrate binding site [chemical binding]; other site 218491000684 FMN binding site [chemical binding]; other site 218491000685 putative catalytic residues [active] 218491000686 HMMPfam hit to PF01070, DE FMN-dependent dehydrogenase, score 2.1e-220 218491000687 PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 218491000688 Domain of unknown function DUF20; Region: UPF0118; pfam01594 218491000689 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 218491000690 8 probable transmembrane helices predicted for ECA0120 by TMHMM2.0 at aa 7-29, 49-82, 102-124, 191-213, 254-276, 286-308, 315-337 and 359-381 218491000691 HMMPfam hit to PF01594, DE Domain of unknown function DUF20, score 5.4e-53 218491000692 Protein of unknown function, DUF596; Region: DUF596; pfam04591 218491000693 Signal peptide predicted for ECA0123 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.427 between residues 23 and 24; signal peptide 218491000694 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491000695 Signal peptide predicted for ECA0124 by SignalP 2.0 HMM (Signal peptide probabilty 0.900) with cleavage site probability 0.815 between residues 18 and 19; signal peptide 218491000696 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491000697 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 218491000698 HipA N-terminal domain; Region: Couple_hipA; cl11853 218491000699 HipA-like N-terminal domain; Region: HipA_N; pfam07805 218491000700 HipA-like C-terminal domain; Region: HipA_C; pfam07804 218491000701 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 218491000702 active site 218491000703 Zn binding site [ion binding]; other site 218491000704 HMMPfam hit to PF00383, DE Cytidine and deoxycytidylate deaminase zinc-binding region, score 6.4e-16 218491000705 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218491000706 hypothetical protein; Provisional; Region: PRK11820 218491000707 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 218491000708 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 218491000709 HMMPfam hit to PF03755, DE YicC-like family, N-terminal region, score 3.6e-79 218491000710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491000711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491000712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491000713 dimerization interface [polypeptide binding]; other site 218491000714 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 8.7e-32 218491000715 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 4e-15 218491000716 Predicted helix-turn-helix motif with score 1984.000, SD 5.94 at aa 16-37, sequence GTISGAARLLNVSQPNVSRVLN 218491000717 Signal peptide predicted for ECA0132 by SignalP 2.0 HMM (Signal peptide probabilty 0.796) with cleavage site probability 0.786 between residues 21 and 22; signal peptide 218491000718 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 218491000719 catalytic nucleophile [active] 218491000720 HMMPfam hit to PF01112, DE Asparaginase, score 1.6e-125 218491000721 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 218491000722 SxDxEG motif; other site 218491000723 active site 218491000724 metal binding site [ion binding]; metal-binding site 218491000725 homopentamer interface [polypeptide binding]; other site 218491000726 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 218491000727 homodimer interface [polypeptide binding]; other site 218491000728 homotetramer interface [polypeptide binding]; other site 218491000729 active site pocket [active] 218491000730 cleavage site 218491000731 HMMPfam hit to PF03576, DE Peptidase family T4, score 1.6e-74 218491000732 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 218491000733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491000734 dimer interface [polypeptide binding]; other site 218491000735 conserved gate region; other site 218491000736 putative PBP binding loops; other site 218491000737 ABC-ATPase subunit interface; other site 218491000738 5 probable transmembrane helices predicted for ECA0135 by TMHMM2.0 at aa 35-57, 98-120, 147-169, 217-239 and 264-286 218491000739 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.066 218491000740 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 218491000741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491000742 dimer interface [polypeptide binding]; other site 218491000743 conserved gate region; other site 218491000744 putative PBP binding loops; other site 218491000745 ABC-ATPase subunit interface; other site 218491000746 6 probable transmembrane helices predicted for ECA0136 by TMHMM2.0 at aa 5-27, 100-122, 135-157, 172-191, 227-249 and 277-299 218491000747 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.00033 218491000748 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491000749 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 218491000750 Signal peptide predicted for ECA0137 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.922 between residues 24 and 25; signal peptide 218491000751 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 218491000752 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 1.3e-81 218491000753 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 218491000754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491000755 Walker A/P-loop; other site 218491000756 ATP binding site [chemical binding]; other site 218491000757 Q-loop/lid; other site 218491000758 ABC transporter signature motif; other site 218491000759 Walker B; other site 218491000760 D-loop; other site 218491000761 H-loop/switch region; other site 218491000762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218491000763 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491000764 Walker A/P-loop; other site 218491000765 ATP binding site [chemical binding]; other site 218491000766 Q-loop/lid; other site 218491000767 ABC transporter signature motif; other site 218491000768 Walker B; other site 218491000769 D-loop; other site 218491000770 H-loop/switch region; other site 218491000771 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218491000772 HMMPfam hit to PF00005, DE ABC transporter, score 1.1e-57 218491000773 PS00211 ABC transporters family signature. 218491000774 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000775 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-55 218491000776 PS00211 ABC transporters family signature. 218491000777 PS00017 ATP/GTP-binding site motif A (P-loop). 218491000778 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 218491000779 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 218491000780 active site 218491000781 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 3.7e-18 218491000782 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 9.3e-05 218491000783 ribonuclease PH; Reviewed; Region: rph; PRK00173 218491000784 Ribonuclease PH; Region: RNase_PH_bact; cd11362 218491000785 hexamer interface [polypeptide binding]; other site 218491000786 active site 218491000787 HMMPfam hit to PF01138, DE 3' exoribonuclease family, domain 1, score 1.3e-53 218491000788 PS01277 Ribonuclease PH signature. 218491000789 HMMPfam hit to PF03725, DE 3' exoribonuclease family, domain 2, score 3.6e-21 218491000790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491000791 active site 218491000792 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 6.1e-30 218491000793 PS00136 Serine proteases, subtilase family, aspartic acid active site. 218491000794 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491000795 division inhibitor protein; Provisional; Region: slmA; PRK09480 218491000796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491000797 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 2.7e-08 218491000798 PS01081 Bacterial regulatory proteins, tetR family signature. 218491000799 Predicted helix-turn-helix motif with score 1905.000, SD 5.68 at aa 32-53, sequence ITTAKLAANVGVSEAALYRHFP 218491000800 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218491000801 trimer interface [polypeptide binding]; other site 218491000802 active site 218491000803 HMMPfam hit to PF00692, DE dUTPase, score 4.7e-51 218491000804 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 218491000805 Flavoprotein; Region: Flavoprotein; pfam02441 218491000806 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 218491000807 HMMPfam hit to PF02441, DE Flavoprotein, score 3.5e-47 218491000808 hypothetical protein; Reviewed; Region: PRK00024 218491000809 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 218491000810 MPN+ (JAMM) motif; other site 218491000811 Zinc-binding site [ion binding]; other site 218491000812 PS01302 DNA repair protein radC family signature. 218491000813 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 218491000814 HMMPfam hit to PF00830, DE Ribosomal L28 family, score 4.6e-35 218491000815 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 218491000816 HMMPfam hit to PF00471, DE Ribosomal protein L33, score 5.3e-24 218491000817 PS00582 Ribosomal protein L33 signature. 218491000818 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 218491000819 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 218491000820 DNA binding site [nucleotide binding] 218491000821 catalytic residue [active] 218491000822 H2TH interface [polypeptide binding]; other site 218491000823 putative catalytic residues [active] 218491000824 turnover-facilitating residue; other site 218491000825 intercalation triad [nucleotide binding]; other site 218491000826 8OG recognition residue [nucleotide binding]; other site 218491000827 putative reading head residues; other site 218491000828 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 218491000829 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218491000830 HMMPfam hit to PF01149, DE Formamidopyrimidine-DNA glycosylase, score 7.8e-140 218491000831 PS01242 Formamidopyrimidine-DNA glycosylase signature. 218491000832 lipopolysaccharide biosynthetic cluster 218491000833 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 218491000834 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218491000835 putative active site [active] 218491000836 HMMPfam hit to PF01075, DE Glycosyltransferase family 9 (heptosyltransferase), score 0.0015 218491000837 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 218491000838 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 218491000839 active site 218491000840 (T/H)XGH motif; other site 218491000841 HMMPfam hit to PF01467, DE Cytidylyltransferase, score 6.8e-43 218491000842 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 218491000843 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 218491000844 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 218491000845 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 3.5e-08 218491000846 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 218491000847 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218491000848 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 218491000849 putative metal binding site; other site 218491000850 HMMPfam hit to PF00535, DE Glycosyl transferase, score 5e-23 218491000851 HMMPfam hit to PF01755, DE Glycosyltransferase family 25 (LPS biosynthesis protein), score 1e-36 218491000852 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 218491000853 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 218491000854 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 218491000855 Ligand binding site; other site 218491000856 metal-binding site 218491000857 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 218491000858 HMMPfam hit to PF01501, DE Glycosyl transferase family 8, score 2.2e-77 218491000859 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 218491000860 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 218491000861 Ligand binding site; other site 218491000862 metal-binding site 218491000863 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 218491000864 HMMPfam hit to PF01501, DE Glycosyl transferase family 8, score 2.9e-74 218491000865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218491000866 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218491000867 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 4.5e-37 218491000868 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491000869 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 218491000870 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218491000871 putative active site [active] 218491000872 HMMPfam hit to PF01075, DE Glycosyltransferase family 9 (heptosyltransferase), score 1e-36 218491000873 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 218491000874 O-Antigen ligase; Region: Wzy_C; pfam04932 218491000875 10 probable transmembrane helices predicted for ECA0161 by TMHMM2.0 at aa 12-30, 34-53, 60-82, 92-114, 126-143, 158-177, 186-208, 228-247, 337-359 and 379-401 218491000876 Signal peptide predicted for ECA0162 by SignalP 2.0 HMM (Signal peptide probabilty 0.753) with cleavage site probability 0.673 between residues 52 and 53; signal peptide 218491000877 O-Antigen ligase; Region: Wzy_C; pfam04932 218491000878 12 probable transmembrane helices predicted for ECA0162 by TMHMM2.0 at aa 25-47, 51-68, 80-102, 117-135, 142-160, 170-192, 204-221, 225-242, 249-271, 357-379, 384-401 and 406-425 218491000879 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 218491000880 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218491000881 putative active site [active] 218491000882 HMMPfam hit to PF01075, DE Glycosyltransferase family 9 (heptosyltransferase), score 8e-96 218491000883 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 218491000884 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 218491000885 putative active site [active] 218491000886 HMMPfam hit to PF01075, DE Glycosyltransferase family 9 (heptosyltransferase), score 2.5e-103 218491000887 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 218491000888 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 218491000889 NADP binding site [chemical binding]; other site 218491000890 homopentamer interface [polypeptide binding]; other site 218491000891 substrate binding site [chemical binding]; other site 218491000892 active site 218491000893 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 218491000894 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 218491000895 substrate-cofactor binding pocket; other site 218491000896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491000897 catalytic residue [active] 218491000898 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 6.7e-69 218491000899 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 218491000900 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 218491000901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 218491000902 NAD(P) binding site [chemical binding]; other site 218491000903 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 1.5e-101 218491000904 PS00059 Zinc-containing alcohol dehydrogenases signature. 218491000905 Signal peptide predicted for ECA0169 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 23 and 24; signal peptide 218491000906 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 218491000907 NodB motif; other site 218491000908 putative active site [active] 218491000909 putative catalytic site [active] 218491000910 Zn binding site [ion binding]; other site 218491000911 AmiB activator; Provisional; Region: PRK11637 218491000912 Signal peptide predicted for ECA0170 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.932 between residues 47 and 48; signal peptide 218491000913 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 218491000914 Peptidase family M23; Region: Peptidase_M23; pfam01551 218491000915 HMMPfam hit to PF01551, DE Peptidase family M23/M37, score 3.6e-30 218491000916 Predicted helix-turn-helix motif with score 1163.000, SD 3.15 at aa 87-108, sequence QSISQASRQLHETRNTLSTLNK 218491000917 Signal peptide predicted for ECA0171 by SignalP 2.0 HMM (Signal peptide probabilty 0.650) with cleavage site probability 0.292 between residues 29 and 30; signal peptide 218491000918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 218491000919 active site residue [active] 218491000920 HMMPfam hit to PF00581, DE Rhodanese-like domain, score 9.8e-17 218491000921 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 218491000922 SecA binding site; other site 218491000923 Preprotein binding site; other site 218491000924 HMMPfam hit to PF02556, DE Preprotein translocase subunit SecB, score 1.4e-94 218491000925 Signal peptide predicted for ECA0173 by SignalP 2.0 HMM (Signal peptide probabilty 0.623) with cleavage site probability 0.613 between residues 21 and 22; signal peptide 218491000926 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 218491000927 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 218491000928 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 218491000929 HMMPfam hit to PF01210, DE NAD-dependent glycerol-3-phosphate dehydrogenase, score 2.1e-163 218491000930 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 218491000931 serine acetyltransferase; Provisional; Region: cysE; PRK11132 218491000932 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 218491000933 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 218491000934 trimer interface [polypeptide binding]; other site 218491000935 active site 218491000936 substrate binding site [chemical binding]; other site 218491000937 CoA binding site [chemical binding]; other site 218491000938 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 7.5e+02 218491000939 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 37 218491000940 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 51 218491000941 PS00101 Hexapeptide-repeat containing-transferases signature. 218491000942 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 36 218491000943 Signal peptide predicted for ECA0175 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.960 between residues 24 and 25; signal peptide 218491000944 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 218491000945 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491000946 3 probable transmembrane helices predicted for ECA0178 by TMHMM2.0 at aa 13-30, 55-74 and 87-109 218491000947 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218491000948 10 probable transmembrane helices predicted for ECA0179 by TMHMM2.0 at aa 7-26, 36-53, 60-82, 87-109, 116-135, 140-162, 174-196, 206-228, 235-257 and 263-285 218491000949 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 0.023 218491000950 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 4.4e-06 218491000951 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 218491000952 Signal peptide predicted for ECA0180 by SignalP 2.0 HMM (Signal peptide probabilty 0.952) with cleavage site probability 0.609 between residues 34 and 35; signal peptide 218491000953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491000954 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 218491000955 putative dimerization interface [polypeptide binding]; other site 218491000956 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.7e-43 218491000957 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.1e-22 218491000958 PS00044 Bacterial regulatory proteins, lysR family signature. 218491000959 Predicted helix-turn-helix motif with score 1707.000, SD 5.00 at aa 17-38, sequence GSLAAAAAALHQTQSALSHQFS 218491000960 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 218491000961 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 218491000962 THF binding site; other site 218491000963 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 218491000964 substrate binding site [chemical binding]; other site 218491000965 THF binding site; other site 218491000966 zinc-binding site [ion binding]; other site 218491000967 HMMPfam hit to PF01717, DE Methionine synthase, vitamin-B12 independent, score 3.9e-229 218491000968 Signal peptide predicted for ECA0182 by SignalP 2.0 HMM (Signal peptide probabilty 0.935) with cleavage site probability 0.534 between residues 30 and 31; signal peptide 218491000969 CHASE3 domain; Region: CHASE3; cl05000 218491000970 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491000971 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491000972 dimerization interface [polypeptide binding]; other site 218491000973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491000974 dimer interface [polypeptide binding]; other site 218491000975 putative CheW interface [polypeptide binding]; other site 218491000976 2 probable transmembrane helices predicted for ECA0182 by TMHMM2.0 at aa 10-32 and 191-210 218491000977 HMMPfam hit to PF00672, DE HAMP domain, score 1.8e-09 218491000978 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 7.5e-93 218491000979 Signal peptide predicted for ECA0183 by SignalP 2.0 HMM (Signal peptide probabilty 0.879) with cleavage site probability 0.270 between residues 30 and 31; signal peptide 218491000980 CHASE3 domain; Region: CHASE3; cl05000 218491000981 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491000982 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491000983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491000984 dimerization interface [polypeptide binding]; other site 218491000985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491000986 dimer interface [polypeptide binding]; other site 218491000987 putative CheW interface [polypeptide binding]; other site 218491000988 2 probable transmembrane helices predicted for ECA0183 by TMHMM2.0 at aa 10-32 and 191-210 218491000989 HMMPfam hit to PF00672, DE HAMP domain, score 4e-11 218491000990 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.1e-92 218491000991 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 218491000992 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218491000993 HMMPfam hit to PF01738, DE Dienelactone hydrolase family, score 3.8e-98 218491000994 uridine phosphorylase; Provisional; Region: PRK11178 218491000995 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218491000996 HMMPfam hit to PF01048, DE Phosphorylase family, score 2.3e-100 218491000997 PS01232 Purine and other phosphorylases family 1 signature. 218491000998 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 218491000999 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 218491001000 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 218491001001 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 218491001002 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00311, DE Phosphoenolpyruvate carboxylase, score 4e-232 218491001003 PS00393 Phosphoenolpyruvate carboxylase active site 2. 218491001004 PS00781 Phosphoenolpyruvate carboxylase active site 1. 218491001005 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 218491001006 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491001007 active site turn [active] 218491001008 phosphorylation site [posttranslational modification] 218491001009 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491001010 10 probable transmembrane helices predicted for ECA0188 by TMHMM2.0 at aa 105-127, 142-164, 173-195, 210-232, 253-275, 285-307, 328-350, 360-382, 387-409 and 429-451 218491001011 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 7.6e-22 218491001012 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 7.5e-13 218491001013 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491001014 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 218491001015 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 218491001016 putative active site pocket [active] 218491001017 putative metal binding site [ion binding]; other site 218491001018 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 1.3e-25 218491001019 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 218491001020 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 1.5e-38 218491001021 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218491001022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491001023 DNA-binding site [nucleotide binding]; DNA binding site 218491001024 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 218491001025 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 8.9e-14 218491001026 PS00043 Bacterial regulatory proteins, gntR family signature. 218491001027 Predicted helix-turn-helix motif with score 1671.000, SD 4.88 at aa 31-52, sequence PPERQLAEEYGVSRFTIRQALE 218491001028 acetylornithine deacetylase; Provisional; Region: PRK05111 218491001029 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 218491001030 metal binding site [ion binding]; metal-binding site 218491001031 putative dimer interface [polypeptide binding]; other site 218491001032 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 1.9e-70 218491001033 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 218491001034 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218491001035 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 218491001036 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218491001037 HMMPfam hit to PF01118, DE Semialdehyde dehydrogenase, NAD binding domain, score 2.2e-48 218491001038 PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 218491001039 HMMPfam hit to PF02774, DE Semialdehyde dehydrogenase, dimerisation domain, score 3e-33 218491001040 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 218491001041 nucleotide binding site [chemical binding]; other site 218491001042 N-acetyl-L-glutamate binding site [chemical binding]; other site 218491001043 HMMPfam hit to PF00696, DE Amino acid kinase family, score 2.5e-39 218491001044 argininosuccinate lyase; Provisional; Region: PRK04833 218491001045 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 218491001046 active sites [active] 218491001047 tetramer interface [polypeptide binding]; other site 218491001048 HMMPfam hit to PF00206, DE Lyase, score 2.1e-176 218491001049 PS00163 Fumarate lyases signature. 218491001050 RmuC family; Region: RmuC; pfam02646 218491001051 1 probable transmembrane helix predicted for ECA0195 by TMHMM2.0 at aa 5-27 218491001052 HMMPfam hit to PF02646, DE RmuC family, score 1.5e-183 218491001053 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 218491001054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491001055 S-adenosylmethionine binding site [chemical binding]; other site 218491001056 HMMPfam hit to PF01209, DE ubiE/COQ5 methyltransferase family, score 1.1e-150 218491001057 PS01183 ubiE/COQ5 methyltransferase family signature 1. 218491001058 PS01184 ubiE/COQ5 methyltransferase family signature 2. 218491001059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 218491001060 SCP-2 sterol transfer family; Region: SCP2; pfam02036 218491001061 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 218491001062 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 218491001063 HMMPfam hit to PF03109, DE ABC1 family, score 6.5e-52 218491001064 2 probable transmembrane helices predicted for ECA0198 by TMHMM2.0 at aa 499-521 and 525-542 218491001065 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 218491001066 HMMPfam hit to PF02416, DE mttA/Hcf106 family, score 6.8e-09 218491001067 1 probable transmembrane helix predicted for ECA0199 by TMHMM2.0 at aa 4-21 218491001068 sec-independent translocase; Provisional; Region: PRK01770 218491001069 HMMPfam hit to PF02416, DE mttA/Hcf106 family, score 0.00081 218491001070 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 218491001071 HMMPfam hit to PF00902, DE Sec-independent protein translocase protein (TatC), score 3.9e-94 218491001072 6 probable transmembrane helices predicted for ECA0201 by TMHMM2.0 at aa 20-42, 74-96, 116-138, 158-180, 193-212 and 216-238 218491001073 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218491001074 active site 218491001075 HMMPfam hit to PF01026, DE TatD related DNase, score 5e-99 218491001076 PS01091 Uncharacterized protein family UPF0006 signature 3. 218491001077 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 218491001078 dimer interface [polypeptide binding]; other site 218491001079 allosteric magnesium binding site [ion binding]; other site 218491001080 active site 218491001081 aspartate-rich active site metal binding site; other site 218491001082 Schiff base residues; other site 218491001083 HMMPfam hit to PF00490, DE Delta-aminolevulinic acid dehydratase, score 2.1e-198 218491001084 PS00169 Delta-aminolevulinic acid dehydratase active site. 218491001085 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 218491001086 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 218491001087 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 218491001088 HMMPfam hit to PF01977, DE 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 1e-240 218491001089 FMN reductase; Validated; Region: fre; PRK08051 218491001090 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 218491001091 FAD binding pocket [chemical binding]; other site 218491001092 FAD binding motif [chemical binding]; other site 218491001093 phosphate binding motif [ion binding]; other site 218491001094 beta-alpha-beta structure motif; other site 218491001095 NAD binding pocket [chemical binding]; other site 218491001096 HMMPfam hit to PF00175, DE Oxidoreductase NAD-binding domain, score 5.6e-37 218491001097 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 218491001098 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218491001099 dimer interface [polypeptide binding]; other site 218491001100 active site 218491001101 HMMPfam hit to PF02803, DE Thiolase, C-terminal domain, score 4e-76 218491001102 PS00099 Thiolases active site. 218491001103 PS00737 Thiolases signature 2. 218491001104 HMMPfam hit to PF00108, DE Thiolase, N-terminal domain, score 2.6e-134 218491001105 Predicted helix-turn-helix motif with score 1151.000, SD 3.11 at aa 138-159, sequence RTIAKAAGMMGLTAEMLARMHN 218491001106 PS00098 Thiolases acyl-enzyme intermediate signature. 218491001107 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 218491001108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218491001109 substrate binding site [chemical binding]; other site 218491001110 oxyanion hole (OAH) forming residues; other site 218491001111 trimer interface [polypeptide binding]; other site 218491001112 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 218491001113 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218491001114 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218491001115 HMMPfam hit to PF00725, DE 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, score 1.6e-37 218491001116 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 218491001117 HMMPfam hit to PF02737, DE 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, score 1.4e-101 218491001118 HMMPfam hit to PF00378, DE Enoyl-CoA hydratase/isomerase family, score 1.1e-75 218491001119 proline dipeptidase; Provisional; Region: PRK13607 218491001120 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 218491001121 active site 218491001122 HMMPfam hit to PF00557, DE metallopeptidase family M24, score 3.2e-76 218491001123 PS00491 Aminopeptidase P and proline dipeptidase signature. 218491001124 hypothetical protein; Provisional; Region: PRK11568 218491001125 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 218491001126 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 218491001127 HMMPfam hit to PF01205, DE Uncharacterized protein family UPF0029, score 6.9e-52 218491001128 PS00910 Uncharacterized protein family UPF0029 signature. 218491001129 potassium transporter; Provisional; Region: PRK10750 218491001130 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 218491001131 11 probable transmembrane helices predicted for ECA0211 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-207, 238-260, 273-295, 326-348, 397-419, 424-443 and 456-478 218491001132 HMMPfam hit to PF00115, DE Cytochrome C and Quinol oxidase polypeptide I, score 0.46 218491001133 HMMPfam hit to PF02386, DE Cation transport protein, score 4.1e-159 218491001134 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 218491001135 PS00201 Flavodoxin signature. 218491001136 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 218491001137 FAD binding domain; Region: FAD_binding_4; pfam01565 218491001138 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 218491001139 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001140 HMMPfam hit to PF01565, DE FAD binding domain, score 0.0013 218491001141 HMMPfam hit to PF02873, DE UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain, score 2.7e-58 218491001142 Biotin operon repressor [Transcription]; Region: BirA; COG1654 218491001143 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 218491001144 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 218491001145 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 218491001146 Predicted helix-turn-helix motif with score 1475.000, SD 4.21 at aa 20-41, sequence YSGEVLGEMMGMSRAAINKHIQ 218491001147 HMMPfam hit to PF03099, DE Biotin/lipoate A/B protein ligase family, score 8.2e-37 218491001148 HMMPfam hit to PF02237, DE Biotin protein ligase C terminal domain, score 2.7e-08 218491001149 pantothenate kinase; Provisional; Region: PRK05439 218491001150 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 218491001151 ATP-binding site [chemical binding]; other site 218491001152 CoA-binding site [chemical binding]; other site 218491001153 Mg2+-binding site [ion binding]; other site 218491001154 HMMPfam hit to PF00485, DE Phosphoribulokinase / Uridine kinase family, score 3.9e-05 218491001155 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001156 elongation factor Tu; Reviewed; Region: PRK00049 218491001157 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 218491001158 G1 box; other site 218491001159 GEF interaction site [polypeptide binding]; other site 218491001160 GTP/Mg2+ binding site [chemical binding]; other site 218491001161 Switch I region; other site 218491001162 G2 box; other site 218491001163 G3 box; other site 218491001164 Switch II region; other site 218491001165 G4 box; other site 218491001166 G5 box; other site 218491001167 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218491001168 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 218491001169 Antibiotic Binding Site [chemical binding]; other site 218491001170 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 6.5e-95 218491001171 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001172 PS00301 GTP-binding elongation factors signature. 218491001173 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 3.5e-28 218491001174 HMMPfam hit to PF03143, DE Elongation factor Tu C-terminal domain, score 6.5e-60 218491001175 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 218491001176 3 probable transmembrane helices predicted for ECA0217 by TMHMM2.0 at aa 15-34, 41-63 and 94-116 218491001177 HMMPfam hit to PF00584, DE SecE/Sec61-gamma subunits of protein translocation complex, score 3.2e-25 218491001178 PS01067 Protein secE/sec61-gamma signature. 218491001179 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 218491001180 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 218491001181 putative homodimer interface [polypeptide binding]; other site 218491001182 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 218491001183 heterodimer interface [polypeptide binding]; other site 218491001184 homodimer interface [polypeptide binding]; other site 218491001185 HMMPfam hit to PF02357, DE Transcription termination factor nusG, score 8.5e-21 218491001186 HMMPfam hit to PF00467, DE KOW motif, score 1.6e-10 218491001187 PS01014 Transcription termination factor nusG signature. 218491001188 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 218491001189 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 218491001190 23S rRNA interface [nucleotide binding]; other site 218491001191 L7/L12 interface [polypeptide binding]; other site 218491001192 putative thiostrepton binding site; other site 218491001193 L25 interface [polypeptide binding]; other site 218491001194 HMMPfam hit to PF03946, DE Ribosomal protein L11, N-terminal domain, score 1.8e-36 218491001195 HMMPfam hit to PF00298, DE Ribosomal protein L11, RNA binding domain, score 1.7e-35 218491001196 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00359 Ribosomal protein L11 signature. 218491001197 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 218491001198 mRNA/rRNA interface [nucleotide binding]; other site 218491001199 HMMPfam hit to PF00687, DE Ribosomal protein L1p/L10e family, score 1.1e-125 218491001200 PS01199 Ribosomal protein L1 signature. 218491001201 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 218491001202 23S rRNA interface [nucleotide binding]; other site 218491001203 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 218491001204 HMMPfam hit to PF00466, DE Ribosomal protein L10, score 2.1e-36 218491001205 PS01109 Ribosomal protein L10 signature. 218491001206 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 218491001207 core dimer interface [polypeptide binding]; other site 218491001208 peripheral dimer interface [polypeptide binding]; other site 218491001209 L10 interface [polypeptide binding]; other site 218491001210 L11 interface [polypeptide binding]; other site 218491001211 putative EF-Tu interaction site [polypeptide binding]; other site 218491001212 putative EF-G interaction site [polypeptide binding]; other site 218491001213 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00542, DE Ribosomal protein L7/L12 C-terminal domain, score 3.2e-37 218491001214 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 218491001215 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 218491001216 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 218491001217 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218491001218 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 218491001219 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218491001220 RPB3 interaction site [polypeptide binding]; other site 218491001221 RPB1 interaction site [polypeptide binding]; other site 218491001222 RPB11 interaction site [polypeptide binding]; other site 218491001223 RPB10 interaction site [polypeptide binding]; other site 218491001224 HMMPfam hit to PF00562, DE RNA polymerase Rpb2, domain 6, score 0 218491001225 PS01166 RNA polymerases beta chain signature. 218491001226 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 218491001227 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 218491001228 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 218491001229 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 218491001230 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 218491001231 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 218491001232 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 218491001233 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 218491001234 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 218491001235 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 218491001236 DNA binding site [nucleotide binding] 218491001237 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 218491001238 HMMPfam hit to PF00623, DE RNA polymerase Rpb1, domain 2, score 1.2e-291 218491001239 shikimate transporter; Provisional; Region: PRK09952 218491001240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491001241 putative substrate translocation pore; other site 218491001242 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 2.1e-27 218491001243 12 probable transmembrane helices predicted for ECA0225 by TMHMM2.0 at aa 46-68, 83-105, 118-135, 150-172, 185-207, 217-236, 275-297, 310-332, 341-360, 365-384, 405-427 and 432-454 218491001244 PS00217 Sugar transport proteins signature 2. 218491001245 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 218491001246 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491001247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491001248 DNA-binding site [nucleotide binding]; DNA binding site 218491001249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491001250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491001251 homodimer interface [polypeptide binding]; other site 218491001252 catalytic residue [active] 218491001253 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 6.3e-14 218491001254 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 1.4e-06 218491001255 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 218491001256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491001257 FeS/SAM binding site; other site 218491001258 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 218491001259 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 218491001260 ThiS interaction site; other site 218491001261 putative active site [active] 218491001262 tetramer interface [polypeptide binding]; other site 218491001263 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 218491001264 thiS-thiF/thiG interaction site; other site 218491001265 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 218491001266 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 218491001267 ATP binding site [chemical binding]; other site 218491001268 substrate interface [chemical binding]; other site 218491001269 HMMPfam hit to PF00899, DE ThiF family, score 1.1e-48 218491001270 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 218491001271 thiamine phosphate binding site [chemical binding]; other site 218491001272 active site 218491001273 pyrophosphate binding site [ion binding]; other site 218491001274 HMMPfam hit to PF02581, DE Thiamine monophosphate synthase/TENI, score 6.9e-70 218491001275 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491001276 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 218491001277 ThiC-associated domain; Region: ThiC-associated; pfam13667 218491001278 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 218491001279 HMMPfam hit to PF01964, DE ThiC family, score 0 218491001280 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001281 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 218491001282 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 218491001283 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 218491001284 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 218491001285 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 218491001286 putative NADH binding site [chemical binding]; other site 218491001287 putative active site [active] 218491001288 nudix motif; other site 218491001289 putative metal binding site [ion binding]; other site 218491001290 Predicted helix-turn-helix motif with score 1187.000, SD 3.23 at aa 107-128, sequence RSKTELACLCHHCKERYYPQIA 218491001291 HMMPfam hit to PF00293, DE NUDIX domain, score 4.8e-24 218491001292 PS00893 mutT domain signature. 218491001293 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 218491001294 substrate binding site [chemical binding]; other site 218491001295 active site 218491001296 HMMPfam hit to PF01208, DE Uroporphyrinogen decarboxylase (URO-D), score 1.2e-207 218491001297 PS00906 Uroporphyrinogen decarboxylase signature 1. 218491001298 PS00907 Uroporphyrinogen decarboxylase signature 2. 218491001299 Pseudogene. This CDS appears to have a frameshift mutation following codon 95. The frameshift occurs within a polymeric tract of (A)7. Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 endonuclease V Nfi or b3998 or c4955 or z5574 or ecs4921 SWALL:NFI_ECOLI (SWALL:P32679) (223 aa) fasta scores: E(): 1.4e-68, 74.32% id in 222 aa;endonuclease V (pseudogene) 218491001300 1 probable transmembrane helix predicted for ECA0236 by TMHMM2.0 at aa 102-124 218491001301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 218491001302 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001303 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218491001304 IHF dimer interface [polypeptide binding]; other site 218491001305 IHF - DNA interface [nucleotide binding]; other site 218491001306 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00216, DE Bacterial DNA-binding protein, score 5.8e-50 218491001307 PS00045 Bacterial histone-like DNA-binding proteins signature. 218491001308 Signal peptide predicted for ECA0239 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.582 between residues 37 and 38; signal peptide 218491001309 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 218491001310 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001311 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 218491001312 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 218491001313 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 218491001314 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 218491001315 HMMPfam hit to PF02843, DE Phosphoribosylglycinamide synthetase, C domain, score 4.6e-48 218491001316 HMMPfam hit to PF01071, DE Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain, score 3.4e-96 218491001317 PS00184 Phosphoribosylglycinamide synthetase signature. 218491001318 HMMPfam hit to PF02842, DE Phosphoribosylglycinamide synthetase, B domain, score 6.3e-48 218491001319 HMMPfam hit to PF02844, DE Phosphoribosylglycinamide synthetase, N domain, score 2.7e-64 218491001320 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 218491001321 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 218491001322 purine monophosphate binding site [chemical binding]; other site 218491001323 dimer interface [polypeptide binding]; other site 218491001324 putative catalytic residues [active] 218491001325 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 218491001326 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 218491001327 HMMPfam hit to PF01808, DE AICARFT/IMPCHase bienzyme, score 1.1e-210 218491001328 HMMPfam hit to PF02142, DE MGS-like domain, score 8.9e-55 218491001329 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491001330 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491001331 Walker A/P-loop; other site 218491001332 ATP binding site [chemical binding]; other site 218491001333 Q-loop/lid; other site 218491001334 ABC transporter signature motif; other site 218491001335 Walker B; other site 218491001336 D-loop; other site 218491001337 H-loop/switch region; other site 218491001338 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-64 218491001339 PS00211 ABC transporters family signature. 218491001340 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491001342 dimer interface [polypeptide binding]; other site 218491001343 conserved gate region; other site 218491001344 putative PBP binding loops; other site 218491001345 ABC-ATPase subunit interface; other site 218491001346 8 probable transmembrane helices predicted for ECA0243 by TMHMM2.0 at aa 25-47, 94-116, 123-145, 155-177, 198-220, 275-297, 302-320 and 324-346 218491001347 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.1e-21 218491001348 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 218491001349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491001350 conserved gate region; other site 218491001351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491001352 dimer interface [polypeptide binding]; other site 218491001353 ABC-ATPase subunit interface; other site 218491001354 putative PBP binding loops; other site 218491001355 7 probable transmembrane helices predicted for ECA0244 by TMHMM2.0 at aa 28-50, 93-115, 188-210, 231-253, 263-285, 344-363 and 373-395 218491001356 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.5e-19 218491001357 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491001358 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 218491001359 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491001360 substrate binding pocket [chemical binding]; other site 218491001361 membrane-bound complex binding site; other site 218491001362 hinge residues; other site 218491001363 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 1.1e-38 218491001364 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491001365 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491001366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491001367 dimer interface [polypeptide binding]; other site 218491001368 conserved gate region; other site 218491001369 putative PBP binding loops; other site 218491001370 ABC-ATPase subunit interface; other site 218491001371 5 probable transmembrane helices predicted for ECA0246 by TMHMM2.0 at aa 26-48, 61-83, 93-115, 136-158 and 182-204 218491001372 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.6e-14 218491001373 Signal peptide predicted for ECA0247 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 22 and 23; signal peptide 218491001374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491001375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491001376 substrate binding pocket [chemical binding]; other site 218491001377 membrane-bound complex binding site; other site 218491001378 hinge residues; other site 218491001379 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 6.3e-76 218491001380 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491001381 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491001382 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491001383 HMMPfam hit to PF01638, DE Transcriptional regulator, score 4.3e-30 218491001384 Signal peptide predicted for ECA0249 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23 218491001385 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 218491001386 Signal peptide predicted for ECA0250 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25 218491001387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491001388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491001389 active site 218491001390 catalytic tetrad [active] 218491001391 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 2.1e-11 218491001392 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 218491001393 putative catalytic site [active] 218491001394 putative metal binding site [ion binding]; other site 218491001395 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 218491001396 putative catalytic site [active] 218491001397 putative phosphate binding site [ion binding]; other site 218491001398 putative phosphate binding site [ion binding]; other site 218491001399 putative metal binding site [ion binding]; other site 218491001400 HMMPfam hit to PF03372, DE Endonuclease/Exonuclease/phosphatase family, score 1.1e-09 218491001401 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 218491001402 Fic/DOC family; Region: Fic; cl00960 218491001403 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 218491001404 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 218491001405 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 218491001406 HMMPfam hit to PF02954, DE Bacterial regulatory protein, Fis family, score 2.8e-14 218491001407 Predicted helix-turn-helix motif with score 1824.000, SD 5.40 at aa 72-93, sequence GNQTRAALMMGINRGTLRKKLK 218491001408 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 218491001409 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218491001410 FMN binding site [chemical binding]; other site 218491001411 active site 218491001412 catalytic residues [active] 218491001413 substrate binding site [chemical binding]; other site 218491001414 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01207, DE Dihydrouridine synthase (Dus), score 3e-153 218491001415 PS01136 Uncharacterized protein family UPF0034 signature. 218491001416 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 218491001417 Signal peptide predicted for ECA0257 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 19 and 20; signal peptide 218491001418 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 218491001419 active site 218491001420 zinc binding site [ion binding]; other site 218491001421 HMMPfam hit to PF00194, DE Eukaryotic-type carbonic anhydrase, score 1.5e-22 218491001422 PS00162 Eukaryotic-type carbonic anhydrases signature. 218491001423 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 218491001424 Methyltransferase domain; Region: Methyltransf_18; pfam12847 218491001425 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001426 Signal peptide predicted for ECA0259 by SignalP 2.0 HMM (Signal peptide probabilty 0.664) with cleavage site probability 0.645 between residues 23 and 24; signal peptide 218491001427 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 218491001428 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 218491001429 Na binding site [ion binding]; other site 218491001430 13 probable transmembrane helices predicted for ECA0259 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 189-211, 231-253, 273-295, 310-332, 368-386, 391-413, 420-442 and 447-469 218491001431 HMMPfam hit to PF00474, DE Sodium:solute symporter family, score 6.2e-166 218491001432 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 218491001433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218491001434 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 218491001435 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 218491001436 HMMPfam hit to PF02785, DE Biotin carboxylase C-terminal domain, score 8.3e-65 218491001437 HMMPfam hit to PF02786, DE Carbamoyl-phosphate synthase L chain, ATP binding domain, score 5.3e-120 218491001438 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218491001439 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218491001440 HMMPfam hit to PF00289, DE Carbamoyl-phosphate synthase L chain, N-terminal domain, score 3.2e-56 218491001441 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 218491001442 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 218491001443 carboxyltransferase (CT) interaction site; other site 218491001444 biotinylation site [posttranslational modification]; other site 218491001445 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 1.4e-36 218491001446 PS00188 Biotin-requiring enzymes attachment site. 218491001447 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 218491001448 Dehydroquinase class II; Region: DHquinase_II; pfam01220 218491001449 active site 218491001450 trimer interface [polypeptide binding]; other site 218491001451 dimer interface [polypeptide binding]; other site 218491001452 HMMPfam hit to PF01220, DE Dehydroquinase class II, score 4.8e-89 218491001453 PS01029 Dehydroquinase class II signature. 218491001454 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 218491001455 6 probable transmembrane helices predicted for ECA0263 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 116-138, 150-167 and 172-189 218491001456 TMAO/DMSO reductase; Reviewed; Region: PRK05363 218491001457 Signal peptide predicted for ECA0264 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.849 between residues 43 and 44; signal peptide 218491001458 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 218491001459 Moco binding site; other site 218491001460 metal coordination site [ion binding]; other site 218491001461 HMMPfam hit to PF00174, DE Oxidoreductase molybdopterin binding domain, score 0.015 218491001462 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001463 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 218491001464 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 218491001465 NADP binding site [chemical binding]; other site 218491001466 dimer interface [polypeptide binding]; other site 218491001467 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 4.3e-37 218491001468 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491001469 regulatory protein CsrD; Provisional; Region: PRK11059 218491001470 Signal peptide predicted for ECA0266 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.595 between residues 34 and 35; signal peptide 218491001471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491001472 metal binding site [ion binding]; metal-binding site 218491001473 active site 218491001474 I-site; other site 218491001475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491001476 2 probable transmembrane helices predicted for ECA0266 by TMHMM2.0 at aa 10-32 and 131-153 218491001477 HMMPfam hit to PF00990, DE GGDEF domain, score 6.2e-14 218491001478 HMMPfam hit to PF00563, DE EAL domain, score 2.1e-37 218491001479 rod shape-determining protein MreB; Provisional; Region: PRK13927 218491001480 MreB and similar proteins; Region: MreB_like; cd10225 218491001481 nucleotide binding site [chemical binding]; other site 218491001482 Mg binding site [ion binding]; other site 218491001483 putative protofilament interaction site [polypeptide binding]; other site 218491001484 RodZ interaction site [polypeptide binding]; other site 218491001485 rod shape-determining protein MreC; Region: mreC; TIGR00219 218491001486 rod shape-determining protein MreC; Region: MreC; pfam04085 218491001487 1 probable transmembrane helix predicted for ECA0268 by TMHMM2.0 at aa 13-35 218491001488 rod shape-determining protein MreD; Provisional; Region: PRK11060 218491001489 4 probable transmembrane helices predicted for ECA0269 by TMHMM2.0 at aa 7-26, 41-63, 68-90 and 105-127 218491001490 Maf-like protein; Region: Maf; pfam02545 218491001491 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 218491001492 active site 218491001493 dimer interface [polypeptide binding]; other site 218491001494 HMMPfam hit to PF02545, DE Maf-like protein, score 3.1e-77 218491001495 ribonuclease G; Provisional; Region: PRK11712 218491001496 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 218491001497 homodimer interface [polypeptide binding]; other site 218491001498 oligonucleotide binding site [chemical binding]; other site 218491001499 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 3.5e-19 218491001500 Signal peptide predicted for ECA0272 by SignalP 2.0 HMM (Signal peptide probabilty 0.905) with cleavage site probability 0.442 between residues 29 and 30; signal peptide 218491001501 hypothetical protein; Provisional; Region: PRK10899 218491001502 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 218491001503 protease TldD; Provisional; Region: tldD; PRK10735 218491001504 HMMPfam hit to PF01523, DE modulator of DNA gyrase, score 4.4e-108 218491001505 transcriptional regulator; Provisional; Region: PRK10632 218491001506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491001507 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491001508 putative effector binding pocket; other site 218491001509 dimerization interface [polypeptide binding]; other site 218491001510 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.4e-40 218491001511 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 5.9e-24 218491001512 PS00044 Bacterial regulatory proteins, lysR family signature. 218491001513 Predicted helix-turn-helix motif with score 1487.000, SD 4.25 at aa 17-38, sequence GSFTAAARQLQMSVSAVSQTVS 218491001514 efflux system membrane protein; Provisional; Region: PRK11594 218491001515 2 probable transmembrane helices predicted for ECA0277 by TMHMM2.0 at aa 7-29 and 44-63 218491001516 Signal peptide predicted for ECA0278 by SignalP 2.0 HMM (Signal peptide probabilty 0.869) with cleavage site probability 0.694 between residues 41 and 42; signal peptide 218491001517 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 218491001518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491001519 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491001520 1 probable transmembrane helix predicted for ECA0278 by TMHMM2.0 at aa 20-42 218491001521 HMMPfam hit to emacsPF00529, DE HlyD family secretion protein, score 1.2e-22 218491001522 Signal peptide predicted for ECA0279 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.985 between residues 62 and 63; signal peptide 218491001523 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 218491001524 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218491001525 10 probable transmembrane helices predicted for ECA0279 by TMHMM2.0 at aa 20-42, 47-69, 76-98, 102-121, 128-150, 380-402, 415-434, 438-457, 464-479 and 494-511 218491001526 succinic semialdehyde dehydrogenase; Region: PLN02278 218491001527 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 218491001528 tetramerization interface [polypeptide binding]; other site 218491001529 NAD(P) binding site [chemical binding]; other site 218491001530 catalytic residues [active] 218491001531 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 2.8e-192 218491001532 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001533 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491001534 hypothetical protein; Provisional; Region: PRK05255 218491001535 peptidase PmbA; Provisional; Region: PRK11040 218491001536 HMMPfam hit to PF01523, DE modulator of DNA gyrase, score 7e-93 218491001537 PS00310 Lysosome-associated membrane glycoproteins duplicated domain signature. 218491001538 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 218491001539 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218491001540 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218491001541 dimerization domain swap beta strand [polypeptide binding]; other site 218491001542 regulatory protein interface [polypeptide binding]; other site 218491001543 active site 218491001544 regulatory phosphorylation site [posttranslational modification]; other site 218491001545 HMMPfam hit to PF00381, DE PTS HPr component phosphorylation site, score 1.2e-31 218491001546 PS00369 PTS HPR component histidine phosphorylation site signature. 218491001547 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 218491001548 HMMPfam hit to PF03668, DE P-loop ATPase protein family, score 2.2e-211 218491001549 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001550 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218491001551 active site 218491001552 phosphorylation site [posttranslational modification] 218491001553 HMMPfam hit to PF00359, DE Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 3.6e-50 218491001554 PS00372 PTS EIIA domains phosphorylation site signature 2. 218491001555 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 218491001556 30S subunit binding site; other site 218491001557 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02482, DE Sigma 54 modulation protein / S30EA ribosomal protein, score 1.2e-51 218491001558 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 218491001559 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 218491001560 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 218491001561 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 218491001562 HMMPfam hit to PF00309, DE Sigma-54 factor, Activator interacting domain (AID), score 7.4e-252 218491001563 PS00718 Sigma-54 factors family signature 2. 218491001564 Predicted helix-turn-helix motif with score 1825.000, SD 5.40 at aa 361-382, sequence MVLADIAQAVDMHESTISRVTT 218491001565 PS00717 Sigma-54 factors family signature 1. 218491001566 PS00041 Bacterial regulatory proteins, araC family signature. 218491001567 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 218491001568 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 218491001569 Walker A/P-loop; other site 218491001570 ATP binding site [chemical binding]; other site 218491001571 Q-loop/lid; other site 218491001572 ABC transporter signature motif; other site 218491001573 Walker B; other site 218491001574 D-loop; other site 218491001575 H-loop/switch region; other site 218491001576 HMMPfam hit to PF00005, DE ABC transporter, score 2.9e-61 218491001577 PS00211 ABC transporters family signature. 218491001578 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001579 Signal peptide predicted for ECA0290 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.621 between residues 27 and 28; signal peptide 218491001580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 218491001581 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 218491001582 HMMPfam hit to PF03968, DE OstA-like protein, score 7.2e-54 218491001583 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 218491001584 Signal peptide predicted for ECA0291 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.756 between residues 25 and 26; signal peptide 218491001585 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 218491001586 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 218491001587 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 218491001588 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 218491001589 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 218491001590 putative active site [active] 218491001591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 218491001592 HMMPfam hit to PF00571, DE CBS domain, score 6.3e-10 218491001593 HMMPfam hit to PF00571, DE CBS domain, score 3.1e-06 218491001594 HMMPfam hit to PF01380, DE SIS domain, score 6.7e-38 218491001595 Signal peptide predicted for ECA0294 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.924 between residues 18 and 19; signal peptide 218491001596 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 218491001597 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 218491001598 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 218491001599 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01699, DE Sodium/calcium exchanger protein, score 8.7e-41 218491001600 9 probable transmembrane helices predicted for ECA0294 by TMHMM2.0 at aa 2-24, 39-61, 74-96, 127-144, 176-195, 210-232, 245-267, 277-294 and 301-320 218491001601 HMMPfam hit to PF01699, DE Sodium/calcium exchanger protein, score 1.7e-44 218491001602 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 218491001603 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 218491001604 Walker A/P-loop; other site 218491001605 ATP binding site [chemical binding]; other site 218491001606 Q-loop/lid; other site 218491001607 ABC transporter signature motif; other site 218491001608 Walker B; other site 218491001609 D-loop; other site 218491001610 H-loop/switch region; other site 218491001611 HMMPfam hit to PF00005, DE ABC transporter, score 7.5e-52 218491001612 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001613 PS00211 ABC transporters family signature. 218491001614 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 218491001615 conserved hypothetical integral membrane protein; Region: TIGR00056 218491001616 HMMPfam hit to PF02405, DE Domain of unknown function DUF140, score 6.3e-126 218491001617 5 probable transmembrane helices predicted for ECA0296 by TMHMM2.0 at aa 55-77, 87-109, 148-170, 197-219 and 239-258 218491001618 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 218491001619 Signal peptide predicted for ECA0297 by SignalP 2.0 HMM (Signal peptide probabilty 0.812) with cleavage site probability 0.333 between residues 19 and 20; signal peptide 218491001620 mce related protein; Region: MCE; pfam02470 218491001621 1 probable transmembrane helix predicted for ECA0297 by TMHMM2.0 at aa 7-26 218491001622 HMMPfam hit to PF02470, DE mce related protein, score 3.1e-41 218491001623 Signal peptide predicted for ECA0298 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 19 and 20; signal peptide 218491001624 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 218491001625 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 218491001626 anti sigma factor interaction site; other site 218491001627 regulatory phosphorylation site [posttranslational modification]; other site 218491001628 HMMPfam hit to PF01740, DE STAS domain, score 7e-07 218491001629 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 218491001630 HMMPfam hit to PF01722, DE BolA-like protein, score 6.3e-35 218491001631 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 218491001632 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 218491001633 hinge; other site 218491001634 active site 218491001635 HMMPfam hit to PF00275, DE EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 2.2e-179 218491001636 serine endoprotease; Provisional; Region: PRK10898 218491001637 Signal peptide predicted for ECA0302 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.471 between residues 33 and 34; signal peptide 218491001638 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218491001639 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218491001640 protein binding site [polypeptide binding]; other site 218491001641 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 8.7e-14 218491001642 HMMPfam hit to PF00089, DE Trypsin, score 1.2e-17 218491001643 serine endoprotease; Provisional; Region: PRK10139 218491001644 Signal peptide predicted for ECA0303 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.799 between residues 27 and 28; signal peptide 218491001645 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218491001646 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218491001647 protein binding site [polypeptide binding]; other site 218491001648 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218491001649 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 5.3e-13 218491001650 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 4e-18 218491001651 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001652 HMMPfam hit to PF00089, DE Trypsin, score 2.3e-21 218491001653 hypothetical protein; Provisional; Region: PRK11677 218491001654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 218491001655 1 probable transmembrane helix predicted for ECA0304 by TMHMM2.0 at aa 5-24 218491001656 Predicted ATPase [General function prediction only]; Region: COG1485 218491001657 HMMPfam hit to PF03969, DE AFG1-like ATPase, score 7.6e-136 218491001658 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001659 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 218491001660 23S rRNA interface [nucleotide binding]; other site 218491001661 L3 interface [polypeptide binding]; other site 218491001662 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00572, DE Ribosomal protein L13, score 7e-86 218491001663 PS00783 Ribosomal protein L13 signature. 218491001664 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 218491001665 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00380, DE Ribosomal protein S9/S16, score 5.4e-70 218491001666 PS00360 Ribosomal protein S9 signature. 218491001667 stringent starvation protein A; Provisional; Region: sspA; PRK09481 218491001668 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 218491001669 C-terminal domain interface [polypeptide binding]; other site 218491001670 putative GSH binding site (G-site) [chemical binding]; other site 218491001671 dimer interface [polypeptide binding]; other site 218491001672 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 218491001673 dimer interface [polypeptide binding]; other site 218491001674 N-terminal domain interface [polypeptide binding]; other site 218491001675 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 1.9e-23 218491001676 HMMPfam hit to PF00043, DE Glutathione S-transferase, C-terminal domain, score 2.1e-14 218491001677 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 218491001678 acetoin reductase; Validated; Region: PRK08643 218491001679 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 218491001680 NAD binding site [chemical binding]; other site 218491001681 homotetramer interface [polypeptide binding]; other site 218491001682 homodimer interface [polypeptide binding]; other site 218491001683 active site 218491001684 substrate binding site [chemical binding]; other site 218491001685 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2.1e-93 218491001686 PS00061 Short-chain dehydrogenases/reductases family signature. 218491001687 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 218491001688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491001689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491001690 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 1.9e-30 218491001691 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 218491001692 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 218491001693 active site 218491001694 dimer interface [polypeptide binding]; other site 218491001695 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 218491001696 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 218491001697 active site 218491001698 FMN binding site [chemical binding]; other site 218491001699 substrate binding site [chemical binding]; other site 218491001700 3Fe-4S cluster binding site [ion binding]; other site 218491001701 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 218491001702 domain interface; other site 218491001703 HMMPfam hit to PF01493, DE Domain of unknown function DUF14, score 2.1e-102 218491001704 HMMPfam hit to PF01645, DE Conserved region in glutamate synthase, score 1.4e-234 218491001705 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001706 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001707 radical SAM protein, TIGR01212 family; Region: TIGR01212 218491001708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491001709 FeS/SAM binding site; other site 218491001710 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 218491001711 Signal peptide predicted for ECA0314 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.530 between residues 41 and 42; signal peptide 218491001712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491001713 putative active site [active] 218491001714 heme pocket [chemical binding]; other site 218491001715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491001716 dimer interface [polypeptide binding]; other site 218491001717 phosphorylation site [posttranslational modification] 218491001718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491001719 ATP binding site [chemical binding]; other site 218491001720 Mg2+ binding site [ion binding]; other site 218491001721 G-X-G motif; other site 218491001722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491001723 active site 218491001724 phosphorylation site [posttranslational modification] 218491001725 intermolecular recognition site; other site 218491001726 dimerization interface [polypeptide binding]; other site 218491001727 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218491001728 putative binding surface; other site 218491001729 active site 218491001730 2 probable transmembrane helices predicted for ECA0314 by TMHMM2.0 at aa 20-42 and 55-77 218491001731 HMMPfam hit to PF00989, DE PAS domain, score 1.4e-07 218491001732 HMMPfam hit to PF00785, DE PAC motif, score 0.096 218491001733 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 6.3e-18 218491001734 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.3e-39 218491001735 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 3.2e-30 218491001736 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001737 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 218491001738 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 218491001739 conserved cys residue [active] 218491001740 HMMPfam hit to PF01965, DE DJ-1/PfpI family, score 2.2e-17 218491001741 Signal peptide predicted for ECA0317 by SignalP 2.0 HMM (Signal peptide probabilty 0.874) with cleavage site probability 0.389 between residues 46 and 47; signal peptide 218491001742 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 218491001743 Transglycosylase; Region: Transgly; cl17702 218491001744 1 probable transmembrane helix predicted for ECA0317 by TMHMM2.0 at aa 20-42 218491001745 HMMPfam hit to PF00912, DE Transglycosylase, score 3.9e-71 218491001746 Signal peptide predicted for ECA0318 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.973 between residues 22 and 23; signal peptide 218491001747 Alginate lyase; Region: Alginate_lyase; pfam05426 218491001748 outer membrane lipoprotein; Provisional; Region: PRK11023 218491001749 Signal peptide predicted for ECA0319 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.546 between residues 30 and 31; signal peptide 218491001750 BON domain; Region: BON; pfam04972 218491001751 BON domain; Region: BON; pfam04972 218491001752 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001753 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 218491001754 dimer interface [polypeptide binding]; other site 218491001755 active site 218491001756 HMMPfam hit to PF01380, DE SIS domain, score 4.6e-42 218491001757 hypothetical protein; Reviewed; Region: PRK12497 218491001758 HMMPfam hit to PF02021, DE Uncharacterised protein family UPF0102, score 2.1e-07 218491001759 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 218491001760 Signal peptide predicted for ECA0322 by SignalP 2.0 HMM (Signal peptide probabilty 0.850) with cleavage site probability 0.688 between residues 31 and 32; signal peptide 218491001761 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 218491001762 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 218491001763 putative ligand binding site [chemical binding]; other site 218491001764 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491001765 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 218491001766 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 218491001767 putative SAM binding site [chemical binding]; other site 218491001768 putative homodimer interface [polypeptide binding]; other site 218491001769 HMMPfam hit to PF00590, DE Tetrapyrrole (Corrin/Porphyrin) Methylases, score 1.1e-62 218491001770 PS01296 Uncharacterized protein family UPF0011 signature. 218491001771 primosomal protein DnaI; Provisional; Region: PRK02854 218491001772 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 218491001773 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 218491001774 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 218491001775 putative active site [active] 218491001776 metal binding site [ion binding]; metal-binding site 218491001777 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 218491001778 HMMPfam hit to PF03738, DE Glutathionylspermidine synthase, score 1.1e-167 218491001779 hypothetical protein; Provisional; Region: PRK11653 218491001780 Signal peptide predicted for ECA0329 by SignalP 2.0 HMM (Signal peptide probabilty 0.663) with cleavage site probability 0.344 between residues 36 and 37; signal peptide 218491001781 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 218491001782 Signal peptide predicted for ECA0330 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.914 between residues 24 and 25; signal peptide 218491001783 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 1.7e-49 218491001784 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 1.2e-36 218491001785 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 218491001786 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218491001787 dimer interface [polypeptide binding]; other site 218491001788 ADP-ribose binding site [chemical binding]; other site 218491001789 active site 218491001790 nudix motif; other site 218491001791 metal binding site [ion binding]; metal-binding site 218491001792 HMMPfam hit to PF00293, DE NUDIX domain, score 8.2e-17 218491001793 putative dehydrogenase; Provisional; Region: PRK11039 218491001794 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 218491001795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218491001796 active site 218491001797 metal binding site [ion binding]; metal-binding site 218491001798 hexamer interface [polypeptide binding]; other site 218491001799 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 1.4e-18 218491001800 esterase YqiA; Provisional; Region: PRK11071 218491001801 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 218491001802 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 218491001803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491001804 ATP binding site [chemical binding]; other site 218491001805 Mg2+ binding site [ion binding]; other site 218491001806 G-X-G motif; other site 218491001807 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218491001808 anchoring element; other site 218491001809 dimer interface [polypeptide binding]; other site 218491001810 ATP binding site [chemical binding]; other site 218491001811 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 218491001812 active site 218491001813 metal binding site [ion binding]; metal-binding site 218491001814 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218491001815 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2e-24 218491001816 HMMPfam hit to PF00204, DE DNA gyrase B, score 1.6e-55 218491001817 PS00177 DNA topoisomerase II signature. 218491001818 HMMPfam hit to PF00986, DE DNA gyrase B subunit, carboxyl terminus, score 2.5e-28 218491001819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491001820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491001821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491001822 dimerization interface [polypeptide binding]; other site 218491001823 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 4.9e-21 218491001824 Predicted helix-turn-helix motif with score 1816.000, SD 5.37 at aa 18-39, sequence GSITAAAEQLGQTTSGISRALR 218491001825 PS00044 Bacterial regulatory proteins, lysR family signature. 218491001826 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.6e-44 218491001827 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 218491001828 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02525, DE Flavodoxin-like fold, score 7.8e-68 218491001829 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 218491001830 intersubunit interface [polypeptide binding]; other site 218491001831 active site 218491001832 zinc binding site [ion binding]; other site 218491001833 Na+ binding site [ion binding]; other site 218491001834 HMMPfam hit to PF01116, DE Fructose-bisphosphate aldolase class-II, score 1.3e-69 218491001835 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 218491001836 intersubunit interface [polypeptide binding]; other site 218491001837 active site 218491001838 zinc binding site [ion binding]; other site 218491001839 Na+ binding site [ion binding]; other site 218491001840 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01116, DE Fructose-bisphosphate aldolase class-II, score 3e-45 218491001841 PS00017 ATP/GTP-binding site motif A (P-loop). 218491001842 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 218491001843 8 probable transmembrane helices predicted for ECA0340 by TMHMM2.0 at aa 21-43, 58-80, 101-123, 133-155, 175-197, 217-236, 272-294 and 309-331 218491001844 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 1.3e-13 218491001845 Signal peptide predicted for ECA0341 by SignalP 2.0 HMM (Signal peptide probabilty 0.736) with cleavage site probability 0.445 between residues 19 and 20; signal peptide 218491001846 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218491001847 active site 218491001848 P-loop; other site 218491001849 phosphorylation site [posttranslational modification] 218491001850 HMMPfam hit to PF02379, DE PTS system, Fructose specific IIB subunit, score 6.8e-35 218491001851 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218491001852 active site 218491001853 phosphorylation site [posttranslational modification] 218491001854 HMMPfam hit to PF00359, DE Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 1.1e-11 218491001855 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 218491001856 HTH domain; Region: HTH_11; pfam08279 218491001857 Mga helix-turn-helix domain; Region: Mga; pfam05043 218491001858 PRD domain; Region: PRD; pfam00874 218491001859 PRD domain; Region: PRD; pfam00874 218491001860 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 218491001861 active site 218491001862 P-loop; other site 218491001863 phosphorylation site [posttranslational modification] 218491001864 HMMPfam hit to PF00874, DE PRD domain, score 1.3e-08 218491001865 Predicted helix-turn-helix motif with score 1495.000, SD 4.28 at aa 23-44, sequence VTVKDIAHYLDVSEKTVYRDMQ 218491001866 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 218491001867 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 218491001868 CAP-like domain; other site 218491001869 active site 218491001870 primary dimer interface [polypeptide binding]; other site 218491001871 HMMPfam hit to PF00521, DE DNA gyrase/topoisomerase IV, subunit A, score 1.3e-255 218491001872 PS00215 Mitochondrial energy transfer proteins signature. 218491001873 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 218491001874 Signal peptide predicted for ECA0346 by SignalP 2.0 HMM (Signal peptide probabilty 0.787) with cleavage site probability 0.777 between residues 35 and 36; signal peptide 218491001875 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218491001876 putative acyl-acceptor binding pocket; other site 218491001877 HMMPfam hit to PF01553, DE Acyltransferase, score 9.9e-56 218491001878 FtsI repressor; Provisional; Region: PRK10883 218491001879 Signal peptide predicted for ECA0347 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.551 between residues 27 and 28; signal peptide 218491001880 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 218491001881 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 218491001882 HMMPfam hit to PF00394, DE Multicopper oxidase, score 0.17 218491001883 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218491001884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491001885 DNA-binding site [nucleotide binding]; DNA binding site 218491001886 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 218491001887 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 8.9e-13 218491001888 PS00043 Bacterial regulatory proteins, gntR family signature. 218491001889 Predicted helix-turn-helix motif with score 1042.000, SD 2.74 at aa 44-65, sequence PAERLIAQQLGLSRVTVSRSLS 218491001890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491001891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491001892 active site 218491001893 catalytic tetrad [active] 218491001894 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 1.3e-117 218491001895 PS00063 Aldo/keto reductase family active site signature. 218491001896 PS00062 Aldo/keto reductase family signature 2. 218491001897 PS00798 Aldo/keto reductase family signature 1. 218491001898 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 218491001899 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 218491001900 dimer interface [polypeptide binding]; other site 218491001901 active site 218491001902 metal binding site [ion binding]; metal-binding site 218491001903 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 8e-39 218491001904 PS00060 Iron-containing alcohol dehydrogenases signature 2. 218491001905 PS00913 Iron-containing alcohol dehydrogenases signature 1. 218491001906 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 218491001907 dimer interface [polypeptide binding]; other site 218491001908 FMN binding site [chemical binding]; other site 218491001909 NADPH bind site [chemical binding]; other site 218491001910 HMMPfam hit to PF00881, DE Nitroreductase family, score 9.6e-26 218491001911 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 218491001912 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218491001913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491001914 PS00041 Bacterial regulatory proteins, araC family signature. 218491001915 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 3.3e-11 218491001916 Predicted helix-turn-helix motif with score 1308.000, SD 3.64 at aa 226-247, sequence LNVEQLAAEVNMSVSAFHHNFK 218491001917 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 6.6e-05 218491001918 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218491001919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218491001920 4 probable transmembrane helices predicted for ECA0353 by TMHMM2.0 at aa 24-46, 66-88, 158-180 and 190-212 218491001921 HMMPfam hit to PF00597, DE DedA family, score 4.3e-53 218491001922 cystathionine beta-lyase; Provisional; Region: PRK08114 218491001923 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218491001924 homodimer interface [polypeptide binding]; other site 218491001925 substrate-cofactor binding pocket; other site 218491001926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491001927 catalytic residue [active] 218491001928 HMMPfam hit to PF01053, DE Cys/Met metabolism PLP-dependent enzyme, score 4.6e-153 218491001929 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 218491001930 Signal peptide predicted for ECA0355 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.987 between residues 23 and 24; signal peptide 218491001931 DctM-like transporters; Region: DctM; pfam06808 218491001932 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 218491001933 11 probable transmembrane helices predicted for ECA0355 by TMHMM2.0 at aa 13-35, 55-74, 81-103, 171-193, 214-236, 240-257, 277-299, 314-331, 336-353, 363-385 and 398-420 218491001934 HMMPfam hit to PF00597, DE DedA family, score 0.0021 218491001935 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 218491001936 4 probable transmembrane helices predicted for ECA0356 by TMHMM2.0 at aa 13-35, 50-69, 90-112 and 127-149 218491001937 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 218491001938 Signal peptide predicted for ECA0357 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.921 between residues 25 and 26; signal peptide 218491001939 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 218491001940 HMMPfam hit to PF03480, DE Bacterial extracellular solute-binding protein, family 7, score 1.1e-82 218491001941 biopolymer transport protein ExbB; Provisional; Region: PRK10414 218491001942 4 probable transmembrane helices predicted for ECA0358 by TMHMM2.0 at aa 25-47, 110-132, 220-242 and 266-288 218491001943 HMMPfam hit to PF01618, DE MotA/TolQ/ExbB proton channel family, score 1.2e-50 218491001944 biopolymer transport protein ExbD; Provisional; Region: PRK11267 218491001945 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218491001946 HMMPfam hit to PF02472, DE Biopolymer transport protein ExbD/TolR, score 1.8e-20 218491001947 1 probable transmembrane helix predicted for ECA0359 by TMHMM2.0 at aa 20-42 218491001948 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 218491001949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491001950 DNA binding site [nucleotide binding] 218491001951 domain linker motif; other site 218491001952 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 218491001953 dimerization interface [polypeptide binding]; other site 218491001954 ligand binding site [chemical binding]; other site 218491001955 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 4.4e-05 218491001956 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 2.3e-10 218491001957 Predicted helix-turn-helix motif with score 1816.000, SD 5.37 at aa 7-28, sequence ITISDIAALAGVSKSTASLVLN 218491001958 PS00356 Bacterial regulatory proteins, lacI family signature. 218491001959 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 218491001960 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 218491001961 substrate binding [chemical binding]; other site 218491001962 active site 218491001963 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 218491001964 HMMPfam hit to PF00251, DE Glycosyl hydrolases family 32, score 3.2e-162 218491001965 PS00609 Glycosyl hydrolases family 32 active site. 218491001966 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 218491001967 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491001968 active site turn [active] 218491001969 phosphorylation site [posttranslational modification] 218491001970 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491001971 10 probable transmembrane helices predicted for ECA0362 by TMHMM2.0 at aa 108-130, 145-167, 174-196, 211-233, 245-267, 282-304, 317-339, 359-381, 388-407 and 427-449 218491001972 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 2.6e-86 218491001973 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491001974 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 2.1e-17 218491001975 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491001976 Signal peptide predicted for ECA0363 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 22 and 23; signal peptide 218491001977 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 218491001978 trimer interface; other site 218491001979 sugar binding site [chemical binding]; other site 218491001980 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02264, DE LamB porin, score 1.4e-146 218491001981 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218491001982 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 218491001983 putative substrate binding site [chemical binding]; other site 218491001984 putative ATP binding site [chemical binding]; other site 218491001985 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 9.5e-98 218491001986 PS00584 pfkB family of carbohydrate kinases signature 2. 218491001987 PS00583 pfkB family of carbohydrate kinases signature 1. 218491001988 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 218491001989 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 218491001990 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 218491001991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491001992 non-specific DNA binding site [nucleotide binding]; other site 218491001993 salt bridge; other site 218491001994 sequence-specific DNA binding site [nucleotide binding]; other site 218491001995 HMMPfam hit to PF01381, DE Helix-turn-helix, score 1.9e-05 218491001996 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491001997 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 218491001998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491001999 catalytic residue [active] 218491002000 HMMPfam hit to PF00282, DE Pyridoxal-dependent decarboxylase conserved domain, score 5.5e-14 218491002001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491002002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491002003 putative substrate translocation pore; other site 218491002004 12 probable transmembrane helices predicted for ECA0370 by TMHMM2.0 at aa 32-54, 69-91, 104-126, 131-153, 160-182, 192-211, 243-265, 269-291, 304-323, 327-346, 363-385 and 390-409 218491002005 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491002006 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491002007 HMMPfam hit to PF01638, DE Transcriptional regulator, score 4.2e-20 218491002008 hypothetical protein; Provisional; Region: PRK03467 218491002009 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 218491002010 NADH(P)-binding; Region: NAD_binding_10; pfam13460 218491002011 NAD binding site [chemical binding]; other site 218491002012 active site 218491002013 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 218491002014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491002015 FeS/SAM binding site; other site 218491002016 PS01087 Radical activating enzymes signature. 218491002017 HMMPfam hit to PF02143, , score 2e-10 218491002018 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 218491002019 ATP cone domain; Region: ATP-cone; pfam03477 218491002020 Class III ribonucleotide reductase; Region: RNR_III; cd01675 218491002021 effector binding site; other site 218491002022 active site 218491002023 Zn binding site [ion binding]; other site 218491002024 glycine loop; other site 218491002025 HMMPfam hit to PF01228, DE Glycine radical, score 5.5e-53 218491002026 PS00850 Glycine radical signature. 218491002027 HMMPfam hit to PF03477, DE ATP cone domain, score 2.9e-25 218491002028 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 218491002029 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 218491002030 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 218491002031 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 218491002032 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 218491002033 HMMPfam hit to PF01841, DE Transglutaminase-like superfamily, score 1.1e-16 218491002034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 218491002035 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 218491002036 Uncharacterized conserved protein [Function unknown]; Region: COG2308 218491002037 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 218491002038 homotrimer interaction site [polypeptide binding]; other site 218491002039 putative active site [active] 218491002040 HMMPfam hit to PF01042, DE Endoribonuclease L-PSP, score 1.2e-58 218491002041 PS01094 Uncharacterized protein family UPF0076 signature. 218491002042 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 218491002043 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 218491002044 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 218491002045 HMMPfam hit to PF02748, DE Aspartate carbamoyltransferase regulatory chain, metal binding domain, score 2.1e-26 218491002046 HMMPfam hit to PF01948, DE Aspartate carbamoyltransferase regulatory chain, allosteric domain, score 1e-55 218491002047 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 218491002048 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218491002049 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 218491002050 HMMPfam hit to PF00185, DE Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 3.1e-56 218491002051 HMMPfam hit to PF02729, DE Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 1.7e-71 218491002052 PS00097 Aspartate and ornithine carbamoyltransferases signature. 218491002053 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 218491002054 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 218491002055 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218491002056 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 218491002057 HMMPfam hit to PF00185, DE Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 9.2e-99 218491002058 HMMPfam hit to PF02729, DE Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 2.7e-80 218491002059 PS00097 Aspartate and ornithine carbamoyltransferases signature. 218491002060 RNase E inhibitor protein; Provisional; Region: PRK11191 218491002061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 218491002062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491002063 Coenzyme A binding pocket [chemical binding]; other site 218491002064 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 3.1e-18 218491002065 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 218491002066 8 probable transmembrane helices predicted for ECA0387 by TMHMM2.0 at aa 23-45, 73-92, 97-119, 140-162, 172-194, 227-249, 274-296 and 322-344 218491002067 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 218491002068 1 probable transmembrane helix predicted for ECA0388 by TMHMM2.0 at aa 97-119 218491002069 HMMPfam hit to PF01435, DE Peptidase family M48, score 9e-06 218491002070 Signal peptide predicted for ECA0389 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 23 and 24; signal peptide 218491002071 hypothetical protein; Provisional; Region: PRK06489 218491002072 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 218491002073 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 4.8e-11 218491002074 Signal peptide predicted for ECA0390 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.480 between residues 32 and 33; signal peptide 218491002075 Tar ligand binding domain homologue; Region: TarH; pfam02203 218491002076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491002077 dimerization interface [polypeptide binding]; other site 218491002078 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491002079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491002080 dimer interface [polypeptide binding]; other site 218491002081 putative CheW interface [polypeptide binding]; other site 218491002082 2 probable transmembrane helices predicted for ECA0390 by TMHMM2.0 at aa 10-32 and 193-212 218491002083 HMMPfam hit to PF00672, DE HAMP domain, score 8.9e-14 218491002084 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 9.6e-85 218491002085 Signal peptide predicted for ECA0391 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.897 between residues 55 and 56; signal peptide 218491002086 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 218491002087 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 218491002088 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 218491002089 2 probable transmembrane helices predicted for ECA0391 by TMHMM2.0 at aa 4-21 and 28-50 218491002090 HMMPfam hit to PF03865, DE Hemolysin activator HlyB, score 2.3e-09 218491002091 Pseudogene. This CDS appears to have a frameshift mutation around codon 1688. Similar to Yersinia pestis hemolysin ypo2490 SWALL:Q8ZDR6 (EMBL:AJ414152) (2535 aa) fasta scores: E(): 7.4e-93, 41.25% id in 2390 aa, and to Ralstonia solanacearum probable hemagglutinin-related protein rsp1073 or rs02477 SWALL:Q8XQZ5 (EMBL:AL646082) (3322 aa) fasta scores: E(): 1.5e-92, 30.39% id in 3145 aa, and to Erwinia chrysanthemi hemolysin/hemagglutinin-like protein HecA precursor hecA SWALL:AAN38708 (EMBL:AF501263) (3848 aa) fasta scores: E(): 2.6e-91, 31.08% id in 2474 aa; haemolysin/hemagglutinin-like protein (pseudogene) 218491002092 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 218491002093 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 218491002094 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 218491002095 HMMPfam hit to PF01885, DE RNA 2'-phosphotransferase, Tpt1 / KptA family, score 2.7e-65 218491002096 PS00012 Phosphopantetheine attachment site. 218491002097 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 218491002098 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 218491002099 ParB-like nuclease domain; Region: ParB; smart00470 218491002100 HMMPfam hit to PF02195, DE ParB-like nuclease domain, score 6.2e-09 218491002101 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491002102 Predicted membrane protein [Function unknown]; Region: COG2323 218491002103 3 probable transmembrane helices predicted for ECA0401 by TMHMM2.0 at aa 4-26, 38-53 and 57-79 218491002104 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 218491002105 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218491002106 HIGH motif; other site 218491002107 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 218491002108 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218491002109 active site 218491002110 KMSKS motif; other site 218491002111 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 218491002112 tRNA binding surface [nucleotide binding]; other site 218491002113 anticodon binding site; other site 218491002114 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 218491002115 HMMPfam hit to PF00133, DE tRNA synthetases class I (I, L, M and V), score 0 218491002116 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491002117 DNA polymerase III subunit chi; Validated; Region: PRK05728 218491002118 multifunctional aminopeptidase A; Provisional; Region: PRK00913 218491002119 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 218491002120 interface (dimer of trimers) [polypeptide binding]; other site 218491002121 Substrate-binding/catalytic site; other site 218491002122 Zn-binding sites [ion binding]; other site 218491002123 HMMPfam hit to PF00883, DE Cytosol aminopeptidase family, catalytic domain, score 6e-203 218491002124 PS00631 Cytosol aminopeptidase signature. 218491002125 HMMPfam hit to PF02789, DE Cytosol aminopeptidase family, N-terminal domain, score 5.3e-49 218491002126 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 218491002127 Signal peptide predicted for ECA0405 by SignalP 2.0 HMM (Signal peptide probabilty 0.658) with cleavage site probability 0.354 between residues 37 and 38; signal peptide 218491002128 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 218491002129 HMMPfam hit to PF03739, DE Predicted permease YjgP/YjgQ family, score 7.6e-75 218491002130 6 probable transmembrane helices predicted for ECA0405 by TMHMM2.0 at aa 17-39, 59-81, 101-123, 267-289, 296-313 and 328-347 218491002131 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 218491002132 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 218491002133 HMMPfam hit to PF03739, DE Predicted permease YjgP/YjgQ family, score 4e-92 218491002134 6 probable transmembrane helices predicted for ECA0406 by TMHMM2.0 at aa 12-31, 62-79, 100-122, 277-296, 303-320 and 333-355 218491002135 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 218491002136 Predicted transcriptional regulator [Transcription]; Region: COG3905 218491002137 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 218491002138 Predicted kinase [General function prediction only]; Region: COG0645 218491002139 AAA domain; Region: AAA_17; pfam13207 218491002140 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002141 Similar to Bacteriophage P4 integrase inT SWALL:VINT_BPP4 (SWALL:P08320) (439 aa) fasta scores: E(): 5.8e-149, 90.04% id in 412 aa, and to Salmonella typhi integrase sty4821 SWALL:Q8Z112 (EMBL:AL627283) (421 aa) fasta scores: E(): 2.9e-152, 90.9% id in 418 aa. Probable pseudogene arising from frame shift mutations at amino acid resisdues 70, 316 and 341.; intergrase (pseudogene) 218491002142 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00589, DE Phage integrase family, score 0.0058 218491002143 SIR2-like domain; Region: SIR2_2; pfam13289 218491002144 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218491002145 Pseudogene. This CDS contains an in-frame TGA stop codon. Similar to bacteriophage P4 glycoprotein 3 siD SWALL:VSID_BPP4 (SWALL:P05461) (244 aa) fasta scores: E(): 2.8e-19, 35.74% id in 221 aa, and to Salmonella typhi phage capsid protein sty4827 SWALL:Q8Z106 (EMBL:AL627283) (286 aa) fasta scores: E(): 1.4e-15, 33.33% id in 219 aa. Probable pseudogene arising from nonsense mutation after amino acid resisdue 105.; bacteriophage capsid protein (pseudogene) 218491002146 Similar to Xanthomonas axonopodis pv. dieffenbachiae transposase SWALL:Q9F822 (EMBL:AF263433) (363 aa) fasta scores: E(): 1.1e-104, 66.57% id in 359 aa. Probable pseudogene arising from frame shift mutations at amino acid resisdues 88 and 288.; transposase (pseudogene) 218491002147 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01527, DE Transposase, score 7.4e-25 218491002148 Uncharacterized conserved protein [Function unknown]; Region: COG2850 218491002149 Signal peptide predicted for ECA0421 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.913 between residues 29 and 30; signal peptide 218491002150 Secretory lipase; Region: LIP; pfam03583 218491002151 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002152 HMMPfam hit to PF03583, DE Secretory lipase, score 4.7e-07 218491002153 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218491002154 ABC-2 type transporter; Region: ABC2_membrane; cl17235 218491002155 7 probable transmembrane helices predicted for ECA0422 by TMHMM2.0 at aa 15-37, 123-145, 188-210, 231-253, 266-288, 301-323 and 356-378 218491002156 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 218491002157 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 218491002158 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 218491002159 6 probable transmembrane helices predicted for ECA0423 by TMHMM2.0 at aa 13-35, 176-198, 219-241, 256-278, 285-307 and 339-361 218491002160 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 218491002161 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491002162 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491002163 1 probable transmembrane helix predicted for ECA0424 by TMHMM2.0 at aa 13-35 218491002164 Signal peptide predicted for ECA0425 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.947 between residues 31 and 32; signal peptide 218491002165 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 218491002166 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 5.9e-18 218491002167 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 7.8e-15 218491002168 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 218491002169 Aspartase; Region: Aspartase; cd01357 218491002170 active sites [active] 218491002171 tetramer interface [polypeptide binding]; other site 218491002172 HMMPfam hit to PF00206, DE Lyase, score 4.2e-208 218491002173 PS00163 Fumarate lyases signature. 218491002174 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 218491002175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491002176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491002177 dimerization interface [polypeptide binding]; other site 218491002178 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.2e-15 218491002179 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 4e-20 218491002180 PS00044 Bacterial regulatory proteins, lysR family signature. 218491002181 Predicted helix-turn-helix motif with score 1862.000, SD 5.53 at aa 34-55, sequence GSMTAAATRLGLTPSAISQTIR 218491002182 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 218491002183 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218491002184 ligand binding site [chemical binding]; other site 218491002185 HMMPfam hit to PF00691, DE OmpA family, score 2.6e-26 218491002186 5 probable transmembrane helices predicted for ECA0429 by TMHMM2.0 at aa 13-35, 118-140, 153-175, 241-263 and 322-344 218491002187 Signal peptide predicted for ECA0430 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.879 between residues 18 and 19; signal peptide 218491002188 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 218491002189 HNH endonuclease; Region: HNH_2; pfam13391 218491002190 Signal peptide predicted for ECA0433 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.573 between residues 28 and 29; signal peptide 218491002191 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 218491002192 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491002193 Signal peptide predicted for ECA0434 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.261 between residues 30 and 31; signal peptide 218491002194 Nitrate and nitrite sensing; Region: NIT; pfam08376 218491002195 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491002196 HAMP domain; Region: HAMP; pfam00672 218491002197 dimerization interface [polypeptide binding]; other site 218491002198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491002199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491002200 dimer interface [polypeptide binding]; other site 218491002201 putative CheW interface [polypeptide binding]; other site 218491002202 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.5e-64 218491002203 HMMPfam hit to PF00672, DE HAMP domain, score 2.7e-08 218491002204 2 probable transmembrane helices predicted for ECA0434 by TMHMM2.0 at aa 13-32 and 310-332 218491002205 magnesium-transporting ATPase; Provisional; Region: PRK15122 218491002206 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 218491002207 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218491002208 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 218491002209 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 218491002210 Soluble P-type ATPase [General function prediction only]; Region: COG4087 218491002211 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 218491002212 8 probable transmembrane helices predicted for ECA0435 by TMHMM2.0 at aa 70-92, 107-129, 290-312, 322-344, 714-736, 774-796, 832-854 and 869-891 218491002213 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 8.1e-17 218491002214 PS00154 E1-E2 ATPases phosphorylation site. 218491002215 HMMPfam hit to PF00122, DE E1-E2 ATPase, score 3.1e-75 218491002216 HMMPfam hit to PF00690, DE Cation transporter/ATPase, N-terminus, score 3.5e-16 218491002217 Signal peptide predicted for ECA0436 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.468 between residues 35 and 36; signal peptide 218491002218 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491002219 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491002220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491002221 dimer interface [polypeptide binding]; other site 218491002222 putative CheW interface [polypeptide binding]; other site 218491002223 HMMPfam hit to PF03915, DE Actin interacting protein 3, score 18 218491002224 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 5.4e-95 218491002225 2 probable transmembrane helices predicted for ECA0436 by TMHMM2.0 at aa 10-32 and 191-210 218491002226 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 218491002227 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 218491002228 intersubunit interface [polypeptide binding]; other site 218491002229 active site 218491002230 Zn2+ binding site [ion binding]; other site 218491002231 HMMPfam hit to PF00596, DE Class II Aldolase and Adducin N-terminal domain, score 1.6e-18 218491002232 L-rhamnose isomerase; Provisional; Region: PRK01076 218491002233 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 218491002234 N- and C-terminal domain interface [polypeptide binding]; other site 218491002235 active site 218491002236 putative catalytic site [active] 218491002237 metal binding site [ion binding]; metal-binding site 218491002238 ATP binding site [chemical binding]; other site 218491002239 rhamnulokinase; Provisional; Region: rhaB; PRK10640 218491002240 carbohydrate binding site [chemical binding]; other site 218491002241 HMMPfam hit to PF00370, DE FGGY family of carbohydrate kinases, N-terminal domain, score 2e-18 218491002242 transcriptional activator RhaS; Provisional; Region: PRK13503 218491002243 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491002244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491002245 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 2.5e-05 218491002246 Predicted helix-turn-helix motif with score 1068.000, SD 2.82 at aa 189-210, sequence VNWGGLADQFSLPLRTLHRQLK 218491002247 PS00041 Bacterial regulatory proteins, araC family signature. 218491002248 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 7e-11 218491002249 transcriptional activator RhaR; Provisional; Region: PRK13501 218491002250 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491002251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491002252 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.34 218491002253 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.5e-10 218491002254 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 218491002255 antitoxin YefM; Provisional; Region: PRK11409 218491002256 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02604, DE Uncharacterized ACR, COG2161, score 1.4e-41 218491002257 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218491002258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491002259 Walker A/P-loop; other site 218491002260 ATP binding site [chemical binding]; other site 218491002261 Q-loop/lid; other site 218491002262 ABC transporter signature motif; other site 218491002263 Walker B; other site 218491002264 D-loop; other site 218491002265 H-loop/switch region; other site 218491002266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491002267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491002268 Walker A/P-loop; other site 218491002269 ATP binding site [chemical binding]; other site 218491002270 Q-loop/lid; other site 218491002271 ABC transporter signature motif; other site 218491002272 Walker B; other site 218491002273 D-loop; other site 218491002274 H-loop/switch region; other site 218491002275 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491002276 HMMPfam hit to PF00005, DE ABC transporter, score 2.2e-59 218491002277 PS00211 ABC transporters family signature. 218491002278 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002279 HMMPfam hit to PF00005, DE ABC transporter, score 1e-42 218491002280 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002281 Signal peptide predicted for ECA0446 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.645 between residues 51 and 52; signal peptide 218491002282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218491002283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491002284 dimer interface [polypeptide binding]; other site 218491002285 conserved gate region; other site 218491002286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218491002287 ABC-ATPase subunit interface; other site 218491002288 6 probable transmembrane helices predicted for ECA0446 by TMHMM2.0 at aa 21-43, 92-114, 121-143, 153-170, 207-229 and 252-274 218491002289 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.3e-05 218491002290 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491002291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491002292 dimer interface [polypeptide binding]; other site 218491002293 conserved gate region; other site 218491002294 putative PBP binding loops; other site 218491002295 ABC-ATPase subunit interface; other site 218491002296 6 probable transmembrane helices predicted for ECA0447 by TMHMM2.0 at aa 12-34, 107-129, 141-163, 178-200, 235-257 and 285-307 218491002297 Signal peptide predicted for ECA0448 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.971 between residues 28 and 29; signal peptide 218491002298 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491002299 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 218491002300 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 8.2e-48 218491002301 Signal peptide predicted for ECA0449 by SignalP 2.0 HMM (Signal peptide probabilty 0.848) with cleavage site probability 0.730 between residues 34 and 35; signal peptide 218491002302 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 218491002303 3 probable transmembrane helices predicted for ECA0449 by TMHMM2.0 at aa 13-35, 98-120 and 132-154 218491002304 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 218491002305 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 218491002306 10 probable transmembrane helices predicted for ECA0450 by TMHMM2.0 at aa 4-26, 39-58, 68-90, 97-119, 134-156, 169-191, 211-233, 254-273, 288-310 and 323-342 218491002307 hypothetical protein; Provisional; Region: PRK05208 218491002308 Signal peptide predicted for ECA0451 by SignalP 2.0 HMM (Signal peptide probabilty 0.878) with cleavage site probability 0.543 between residues 21 and 22; signal peptide 218491002309 HMMPfam hit to PF03350, DE Uncharacterized protein family, UPF0114, score 1.4e-101 218491002310 3 probable transmembrane helices predicted for ECA0451 by TMHMM2.0 at aa 5-24, 45-67 and 128-148 218491002311 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 218491002312 Prostaglandin dehydrogenases; Region: PGDH; cd05288 218491002313 NAD(P) binding site [chemical binding]; other site 218491002314 substrate binding site [chemical binding]; other site 218491002315 dimer interface [polypeptide binding]; other site 218491002316 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 8.5e-28 218491002317 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 218491002318 1 probable transmembrane helix predicted for ECA0453 by TMHMM2.0 at aa 7-29 218491002319 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 218491002320 2 probable transmembrane helices predicted for ECA0454 by TMHMM2.0 at aa 7-29 and 74-93 218491002321 Predicted helix-turn-helix motif with score 1473.000, SD 4.20 at aa 123-144, sequence MQIRVVAEIFGKNPSALRNAEA 218491002322 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491002323 oxidoreductase; Provisional; Region: PRK08013 218491002324 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 218491002325 HMMPfam hit to PF01360, DE Monooxygenase, score 5.1e-39 218491002326 PS01304 ubiH/COQ6 monooxygenase family signature. 218491002327 Signal peptide predicted for ECA0458 by SignalP 2.0 HMM (Signal peptide probabilty 0.802) with cleavage site probability 0.321 between residues 25 and 26; signal peptide 218491002328 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 218491002329 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 218491002330 HMMPfam hit to PF01360, DE Monooxygenase, score 7.8e-29 218491002331 PS01304 ubiH/COQ6 monooxygenase family signature. 218491002332 proline aminopeptidase P II; Provisional; Region: PRK10879 218491002333 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 218491002334 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 218491002335 active site 218491002336 HMMPfam hit to PF00557, DE metallopeptidase family M24, score 2.3e-101 218491002337 PS00491 Aminopeptidase P and proline dipeptidase signature. 218491002338 hypothetical protein; Reviewed; Region: PRK01736 218491002339 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03695, DE Uncharacterised protein family (UPF0149), score 3.2e-91 218491002340 Z-ring-associated protein; Provisional; Region: PRK10972 218491002341 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 218491002342 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 218491002343 HMMPfam hit to PF01812, DE 5-formyltetrahydrofolate cyclo-ligase family, score 5.1e-62 218491002344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491002345 non-specific DNA binding site [nucleotide binding]; other site 218491002346 salt bridge; other site 218491002347 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 218491002348 sequence-specific DNA binding site [nucleotide binding]; other site 218491002349 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 218491002350 active site 218491002351 (T/H)XGH motif; other site 218491002352 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 218491002353 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491002354 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002355 HMMPfam hit to PF01381, DE Helix-turn-helix, score 8e-06 218491002356 Predicted helix-turn-helix motif with score 1756.000, SD 5.17 at aa 16-37, sequence CTLQQVADATDMTKGYLSQLLN 218491002357 DNA repair protein RadA; Region: sms; TIGR00416 218491002358 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 218491002359 Walker A motif/ATP binding site; other site 218491002360 ATP binding site [chemical binding]; other site 218491002361 Walker B motif; other site 218491002362 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 218491002363 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002364 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 218491002365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491002366 motif I; other site 218491002367 motif II; other site 218491002368 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 2.6e-20 218491002369 hypothetical protein; Provisional; Region: PRK11246 218491002370 Signal peptide predicted for ECA0466 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.259 between residues 40 and 41; signal peptide 218491002371 2 probable transmembrane helices predicted for ECA0466 by TMHMM2.0 at aa 13-35 and 162-184 218491002372 PS00136 Serine proteases, subtilase family, aspartic acid active site. 218491002373 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 218491002374 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 218491002375 G1 box; other site 218491002376 putative GEF interaction site [polypeptide binding]; other site 218491002377 GTP/Mg2+ binding site [chemical binding]; other site 218491002378 Switch I region; other site 218491002379 G2 box; other site 218491002380 G3 box; other site 218491002381 Switch II region; other site 218491002382 G4 box; other site 218491002383 G5 box; other site 218491002384 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 218491002385 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 3.9e-57 218491002386 PS00301 GTP-binding elongation factors signature. 218491002387 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 7e-16 218491002388 periplasmic protein; Provisional; Region: PRK10568 218491002389 Signal peptide predicted for ECA0469 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 25 and 26; signal peptide 218491002390 BON domain; Region: BON; pfam04972 218491002391 BON domain; Region: BON; pfam04972 218491002392 Signal peptide predicted for ECA0470 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.379 between residues 29 and 30; signal peptide 218491002393 2 probable transmembrane helices predicted for ECA0470 by TMHMM2.0 at aa 5-23 and 27-49 218491002394 CsbD-like; Region: CsbD; cl17424 218491002395 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218491002396 active site 218491002397 PS01137 Uncharacterized protein family UPF0006 signature 1. 218491002398 HMMPfam hit to PF01026, DE TatD related DNase, score 3.4e-93 218491002399 PS01091 Uncharacterized protein family UPF0006 signature 3. 218491002400 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 218491002401 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 218491002402 Nucleoside recognition; Region: Gate; pfam07670 218491002403 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 218491002404 HMMPfam hit to PF01773, DE Na+ dependent nucleoside transporter, score 1.1e-225 218491002405 10 probable transmembrane helices predicted for ECA0473 by TMHMM2.0 at aa 4-22, 29-51, 61-83, 96-118, 173-192, 199-221, 267-289, 294-316, 365-387 and 400-422 218491002406 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 218491002407 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 218491002408 Signal peptide predicted for ECA0475 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.604 between residues 37 and 38; signal peptide 218491002409 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 218491002410 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491002411 N-terminal plug; other site 218491002412 ligand-binding site [chemical binding]; other site 218491002413 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 6e-10 218491002414 Signal peptide predicted for ECA0476 by SignalP 2.0 HMM (Signal peptide probabilty 0.815) with cleavage site probability 0.478 between residues 39 and 40; signal peptide 218491002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491002416 putative substrate translocation pore; other site 218491002417 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491002418 10 probable transmembrane helices predicted for ECA0476 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 100-122, 134-153, 163-185, 209-231, 251-273, 286-308 and 373-395 218491002419 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 218491002420 chorismate binding enzyme; Region: Chorismate_bind; cl10555 218491002421 HMMPfam hit to PF00425, DE chorismate binding enzyme, score 7.7e-102 218491002422 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 218491002423 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 218491002424 acyl-activating enzyme (AAE) consensus motif; other site 218491002425 active site 218491002426 AMP binding site [chemical binding]; other site 218491002427 substrate binding site [chemical binding]; other site 218491002428 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 5.3e-104 218491002429 PS00455 AMP-binding domain signature. 218491002430 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 218491002431 hydrophobic substrate binding pocket; other site 218491002432 Isochorismatase family; Region: Isochorismatase; pfam00857 218491002433 active site 218491002434 conserved cis-peptide bond; other site 218491002435 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 218491002436 HMMPfam hit to PF00857, DE Isochorismatase family, score 1.5e-86 218491002437 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 1.3e-11 218491002438 Condensation domain; Region: Condensation; pfam00668 218491002439 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491002440 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491002441 acyl-activating enzyme (AAE) consensus motif; other site 218491002442 AMP binding site [chemical binding]; other site 218491002443 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491002444 HMMPfam hit to PF00668, DE Condensation domain, score 7.1e-18 218491002445 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.4e-115 218491002446 PS00455 AMP-binding domain signature. 218491002447 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 4.5e-17 218491002448 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 218491002449 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 218491002450 putative NAD(P) binding site [chemical binding]; other site 218491002451 active site 218491002452 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 9.4e-64 218491002453 PS00061 Short-chain dehydrogenases/reductases family signature. 218491002454 Condensation domain; Region: Condensation; pfam00668 218491002455 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491002456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 218491002457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491002458 acyl-activating enzyme (AAE) consensus motif; other site 218491002459 AMP binding site [chemical binding]; other site 218491002460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491002461 Condensation domain; Region: Condensation; pfam00668 218491002462 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 218491002463 Condensation domain; Region: Condensation; pfam00668 218491002464 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491002465 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 218491002466 HMMPfam hit to PF00668, DE Condensation domain, score 3.9e-61 218491002467 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.2e-130 218491002468 PS00455 AMP-binding domain signature. 218491002469 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 1.2e-12 218491002470 PS00012 Phosphopantetheine attachment site. 218491002471 HMMPfam hit to PF00668, DE Condensation domain, score 1.1e-53 218491002472 HMMPfam hit to PF00668, DE Condensation domain, score 2.1e-26 218491002473 Predicted helix-turn-helix motif with score 1284.000, SD 3.56 at aa 1804-1825, sequence ATLTAFAREVGITPSIIAQYAW 218491002474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491002475 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491002476 acyl-activating enzyme (AAE) consensus motif; other site 218491002477 AMP binding site [chemical binding]; other site 218491002478 active site 218491002479 CoA binding site [chemical binding]; other site 218491002480 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 3.6e-106 218491002481 PS00455 AMP-binding domain signature. 218491002482 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 218491002483 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 218491002484 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 218491002485 tetramer interface [polypeptide binding]; other site 218491002486 active site 218491002487 Mg2+/Mn2+ binding site [ion binding]; other site 218491002488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491002489 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 218491002490 PYR/PP interface [polypeptide binding]; other site 218491002491 dimer interface [polypeptide binding]; other site 218491002492 TPP binding site [chemical binding]; other site 218491002493 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 218491002494 TPP-binding site; other site 218491002495 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 0.00026 218491002496 PS00187 Thiamine pyrophosphate enzymes signature. 218491002497 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002498 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 218491002499 HMMPfam hit to PF03446, DE NAD binding domain of 6-phosphogluconate dehydrogenase, score 0.00082 218491002500 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 218491002501 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 218491002502 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 218491002503 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 218491002504 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 218491002505 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491002506 Walker A/P-loop; other site 218491002507 ATP binding site [chemical binding]; other site 218491002508 Q-loop/lid; other site 218491002509 ABC transporter signature motif; other site 218491002510 Walker B; other site 218491002511 D-loop; other site 218491002512 H-loop/switch region; other site 218491002513 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491002514 HMMPfam hit to PF00005, DE ABC transporter, score 1.8e-53 218491002515 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002516 PS00211 ABC transporters family signature. 218491002517 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 218491002518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491002519 Walker A/P-loop; other site 218491002520 ATP binding site [chemical binding]; other site 218491002521 Q-loop/lid; other site 218491002522 ABC transporter signature motif; other site 218491002523 Walker B; other site 218491002524 D-loop; other site 218491002525 H-loop/switch region; other site 218491002526 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-51 218491002527 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002528 PS00211 ABC transporters family signature. 218491002529 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 218491002530 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218491002531 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 218491002532 active site 218491002533 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 218491002534 Guanylate kinase; Region: Guanylate_kin; pfam00625 218491002535 active site 218491002536 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 218491002537 putative hydrolase; Provisional; Region: PRK02113 218491002538 capsular polysaccharide locus 218491002539 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 218491002540 Bacterial sugar transferase; Region: Bac_transf; pfam02397 218491002541 4 probable transmembrane helices predicted for ECA0499 by TMHMM2.0 at aa 10-32, 44-63, 78-100 and 247-268 218491002542 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02397, DE Bacterial sugar transferase, score 7.3e-40 218491002543 Signal peptide predicted for ECA0500 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 19 and 20; signal peptide 218491002544 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 218491002545 Signal peptide predicted for ECA0501 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.508 between residues 25 and 26; signal peptide 218491002546 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 218491002547 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 218491002548 SLBB domain; Region: SLBB; pfam10531 218491002549 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 218491002550 Chain length determinant protein; Region: Wzz; pfam02706 218491002551 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 218491002552 HMMPfam hit to PF02706, DE Chain length determinant protein, score 5.9e-19 218491002553 2 probable transmembrane helices predicted for ECA0502 by TMHMM2.0 at aa 29-51 and 427-449 218491002554 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 218491002555 11 probable transmembrane helices predicted for ECA0503 by TMHMM2.0 at aa 10-29, 41-63, 73-95, 100-119, 129-146, 153-175, 219-241, 278-300, 315-337, 350-367 and 371-390 218491002556 12 probable transmembrane helices predicted for ECA0504 by TMHMM2.0 at aa 7-26, 30-49, 62-84, 89-111, 124-146, 166-188, 201-233, 248-270, 324-346, 361-383, 403-422 and 426-448 218491002557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218491002558 active site 218491002559 HMMPfam hit to PF00535, DE Glycosyl transferase, score 6.8e-17 218491002560 1 probable transmembrane helix predicted for ECA0505 by TMHMM2.0 at aa 260-282 218491002561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218491002562 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218491002563 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 3.8e-28 218491002564 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218491002565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218491002566 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 3.1e-21 218491002567 1 probable transmembrane helix predicted for ECA0508 by TMHMM2.0 at aa 82-104 218491002568 Signal peptide predicted for ECA0509 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.459 between residues 21 and 22; signal peptide 218491002569 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 218491002570 putative acyl transferase; Provisional; Region: PRK10191 218491002571 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 218491002572 trimer interface [polypeptide binding]; other site 218491002573 active site 218491002574 substrate binding site [chemical binding]; other site 218491002575 CoA binding site [chemical binding]; other site 218491002576 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 6.3e+02 218491002577 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.011 218491002578 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 4.9e+02 218491002579 PS00101 Hexapeptide-repeat containing-transferases signature. 218491002580 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 5.8 218491002581 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 218491002582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491002583 non-specific DNA binding site [nucleotide binding]; other site 218491002584 salt bridge; other site 218491002585 sequence-specific DNA binding site [nucleotide binding]; other site 218491002586 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 218491002587 Predicted helix-turn-helix motif with score 1058.000, SD 2.79 at aa 20-41, sequence TTLAAVSRASGLASSTLANALT 218491002588 1 probable transmembrane helix predicted for ECA0514 by TMHMM2.0 at aa 13-35 218491002589 Fic family protein [Function unknown]; Region: COG3177 218491002590 Fic/DOC family; Region: Fic; pfam02661 218491002591 This region shows conservation in both sequence and gene order with a large part of SPI-7 from S. typhi 218491002592 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 218491002593 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 218491002594 P-loop; other site 218491002595 Magnesium ion binding site [ion binding]; other site 218491002596 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218491002597 1 probable transmembrane helix predicted for ECA0517 by TMHMM2.0 at aa 135-157 218491002598 replicative DNA helicase; Region: DnaB; TIGR00665 218491002599 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 218491002600 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 218491002601 Walker A motif; other site 218491002602 ATP binding site [chemical binding]; other site 218491002603 Walker B motif; other site 218491002604 DNA binding loops [nucleotide binding] 218491002605 HMMPfam hit to PF00772, DE DnaB-like helicase N terminal domain, score 4.5e-44 218491002606 HMMPfam hit to PF03796, DE DnaB-like helicase C terminal domain, score 7.3e-92 218491002607 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002608 Predicted helix-turn-helix motif with score 1208.000, SD 3.30 at aa 359-380, sequence RSLKAIAKHFNVPLLALSQLNR 218491002609 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 218491002610 ParB-like nuclease domain; Region: ParBc; cl02129 218491002611 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 218491002612 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 218491002613 DNA topoisomerase III; Provisional; Region: PRK07726 218491002614 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 218491002615 active site 218491002616 putative interdomain interaction site [polypeptide binding]; other site 218491002617 putative metal-binding site [ion binding]; other site 218491002618 putative nucleotide binding site [chemical binding]; other site 218491002619 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218491002620 domain I; other site 218491002621 DNA binding groove [nucleotide binding] 218491002622 phosphate binding site [ion binding]; other site 218491002623 domain II; other site 218491002624 domain III; other site 218491002625 nucleotide binding site [chemical binding]; other site 218491002626 catalytic site [active] 218491002627 domain IV; other site 218491002628 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218491002629 HMMPfam hit to PF01751, DE Toprim domain, score 4.2e-18 218491002630 HMMPfam hit to PF01131, DE DNA topoisomerase, score 1.1e-99 218491002631 HMMPfam hit to PF01396, DE Topoisomerase DNA binding C4 zinc finger, score 0.0015 218491002632 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 218491002633 Pseudogene. This CDS appears to have a frameshift mutation following codon 94. Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri single-strand binding protein Ssb or ExrB or LexC or b4059 or c5049 or z5658 or ecs5041 or sf4145 SWALL:SSB_ECOLI (SWALL:P02339) (177 aa) fasta scores: E(): 1.2e-35, 70.62% id in 177 aa, and to Proteus mirabilis single-strand binding protein Ssb SWALL:SSB_PROMI (SWALL:P28046) (173 aa) fasta scores: E(): 3.3e-41, 72.41% id in 174 aa. Also similar to ECA3690 (92.553% id. in 94 aa overlap);single-strand binding protein 2 (pseudogene) 218491002634 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00436, DE Single-strand binding protein family, score 7.1e-45 218491002635 PS00735 Single-strand binding protein family signature 1. 218491002636 PS00736 Single-strand binding protein family signature 2. 218491002637 Domain of unknown function DUF29; Region: DUF29; pfam01724 218491002638 HMMPfam hit to PF01724, DE Domain of unknown function DUF29, score 5.2e-44 218491002639 Signal peptide predicted for ECA0532 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.622 between residues 30 and 31; signal peptide 218491002640 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 218491002641 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 218491002642 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491002643 Signal peptide predicted for ECA0533 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.810 between residues 23 and 24; signal peptide 218491002644 PilM; Region: PilM; pfam07419 218491002645 Signal peptide predicted for ECA0534 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.588 between residues 25 and 26; signal peptide 218491002646 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 218491002647 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218491002648 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00263, DE Bacterial type II and III secretion system protein, score 1e-08 218491002649 Pseudogene. This CDS appears to have a frameshift mutation following codon 172. Similar to Escherichia coli PilO protein PilO SWALL:Q9F534 (EMBL:AP002527) (440 aa) fasta scores: E(): 1.1e-13, 22.22% id in 441 aa, and to Salmonella dublin, and Salmonella typhi PilO SWALL:Q9K2P9 (EMBL:AF247502) (428 aa) fasta scores: E(): 3.8e-27, 31.14% id in 427 aa; Type IV pilus protein (pseudogene) 218491002650 1 probable transmembrane helix predicted for ECA0536 by TMHMM2.0 at aa 5-27 218491002651 Signal peptide predicted for ECA0537 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 18 and 19 218491002652 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 218491002653 Type II/IV secretion system protein; Region: T2SE; pfam00437 218491002654 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 218491002655 Walker A motif; other site 218491002656 ATP binding site [chemical binding]; other site 218491002657 Walker B motif; other site 218491002658 HMMPfam hit to PF00437, DE Type II/IV secretion system protein, score 3e-22 218491002659 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002660 1 probable transmembrane helix predicted for ECA0539 by TMHMM2.0 at aa 15-33 218491002661 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 218491002662 3 probable transmembrane helices predicted for ECA0540 by TMHMM2.0 at aa 109-131, 165-184 and 316-338 218491002663 PilS N terminal; Region: PilS; pfam08805 218491002664 1 probable transmembrane helix predicted for ECA0541 by TMHMM2.0 at aa 33-55 218491002665 Signal peptide predicted for ECA0542 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.920 between residues 22 and 23; signal peptide 218491002666 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 218491002667 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491002668 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491002669 catalytic residue [active] 218491002670 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 4.8e-36 218491002671 Signal peptide predicted for ECA0543 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.775 between residues 20 and 21; signal peptide 218491002672 6 probable transmembrane helices predicted for ECA0543 by TMHMM2.0 at aa 5-24, 34-56, 63-85, 112-134, 151-173 and 188-210 218491002673 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 218491002674 1 probable transmembrane helix predicted for ECA0544 by TMHMM2.0 at aa 29-51 218491002675 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002676 Phage Tail Collar Domain; Region: Collar; pfam07484 218491002677 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 218491002678 catalytic residues [active] 218491002679 Int/Topo IB signature motif; other site 218491002680 HMMPfam hit to PF00589, DE Phage integrase family, score 1.4e-41 218491002681 1 probable transmembrane helix predicted for ECA0547 by TMHMM2.0 at aa 15-37 218491002682 Predicted helix-turn-helix motif with score 1219.000, SD 3.34 at aa 98-119, sequence LQQAQLLAPFGISQGALSSAER 218491002683 Signal peptide predicted for ECA0549 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.979 between residues 24 and 25; signal peptide 218491002684 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 218491002685 3 probable transmembrane helices predicted for ECA0551 by TMHMM2.0 at aa 4-18, 38-57 and 72-94 218491002686 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 218491002687 Signal peptide predicted for ECA0553 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.995 between residues 21 and 22; signal peptide 218491002688 1 probable transmembrane helix predicted for ECA0554 by TMHMM2.0 at aa 66-88 218491002689 Signal peptide predicted for ECA0555 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 18 and 19; signal peptide 218491002690 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 218491002691 Signal peptide predicted for ECA0556 by SignalP 2.0 HMM (Signal peptide probabilty 0.790) with cleavage site probability 0.539 between residues 18 and 19; signal peptide 218491002692 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491002693 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491002694 Signal peptide predicted for ECA0557 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21; signal peptide 218491002695 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 218491002696 Restriction endonuclease; Region: Mrr_cat; pfam04471 218491002697 1 probable transmembrane helix predicted for ECA0558 by TMHMM2.0 at aa 15-37 218491002698 2 probable transmembrane helices predicted for ECA0559 by TMHMM2.0 at aa 26-48 and 113-135 218491002699 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 218491002700 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 218491002701 1 probable transmembrane helix predicted for ECA0560 by TMHMM2.0 at aa 35-57 218491002702 HMMPfam hit to PF02534, DE TraG/TraD family, score 0.032 218491002703 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002704 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 218491002705 3 probable transmembrane helices predicted for ECA0561 by TMHMM2.0 at aa 32-54, 155-177 and 221-243 218491002706 PS00216 Sugar transport proteins signature 1. 218491002707 Signal peptide predicted for ECA0563 by SignalP 2.0 HMM (Signal peptide probabilty 0.750) with cleavage site probability 0.688 between residues 21 and 22; signal peptide 218491002708 2 probable transmembrane helices predicted for ECA0563 by TMHMM2.0 at aa 10-31 and 161-178 218491002709 Signal peptide predicted for ECA0564 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 24 and 25; signal peptide 218491002710 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 218491002711 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 218491002712 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 218491002713 2 probable transmembrane helices predicted for ECA0565 by TMHMM2.0 at aa 32-54 and 69-88 218491002714 Signal peptide predicted for ECA0566 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24; signal peptide 218491002715 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 218491002716 3 probable transmembrane helices predicted for ECA0566 by TMHMM2.0 at aa 7-29, 49-71 and 84-106 218491002717 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 218491002718 PS00409 Prokaryotic N-terminal methylation site. 218491002719 2 probable transmembrane helices predicted for ECA0567 by TMHMM2.0 at aa 26-45 and 50-72 218491002720 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 218491002721 1 probable transmembrane helix predicted for ECA0568 by TMHMM2.0 at aa 15-37 218491002722 Signal peptide predicted for ECA0569 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.998 between residues 29 and 30; signal peptide 218491002723 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 218491002724 Signal peptide predicted for ECA0570 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.788 between residues 34 and 35; signal peptide 218491002725 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 218491002726 Signal peptide predicted for ECA0572 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.607 between residues 22 and 23; signal peptide 218491002727 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 218491002728 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491002729 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 218491002730 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 218491002731 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002732 4 probable transmembrane helices predicted for ECA0575 by TMHMM2.0 at aa 20-39, 59-81, 86-108 and 123-140 218491002733 PS00589 PTS HPR component serine phosphorylation site signature. 218491002734 Signal peptide predicted for ECA0576 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.993 between residues 19 and 20; signal peptide 218491002735 integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757 218491002736 Signal peptide predicted for ECA0577 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.703 between residues 27 and 28; signal peptide 218491002737 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 218491002738 Signal peptide predicted for ECA0578 by SignalP 2.0 HMM (Signal peptide probabilty 0.912) with cleavage site probability 0.864 between residues 21 and 22; signal peptide 218491002739 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 218491002740 Signal peptide predicted for ECA0579 by SignalP 2.0 HMM (Signal peptide probabilty 0.894) with cleavage site probability 0.425 between residues 41 and 42; signal peptide 218491002741 3 probable transmembrane helices predicted for ECA0579 by TMHMM2.0 at aa 23-45, 65-87 and 100-117 218491002742 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 218491002743 6 probable transmembrane helices predicted for ECA0580 by TMHMM2.0 at aa 13-35, 67-89, 334-353, 363-385, 390-407 and 442-464 218491002744 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002745 1 probable transmembrane helix predicted for ECA0581 by TMHMM2.0 at aa 60-82 218491002746 PemK-like protein; Region: PemK; pfam02452 218491002747 HMMPfam hit to PF02452, DE PemK-like protein, score 6.3e-11 218491002748 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 218491002749 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 218491002750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491002751 S-adenosylmethionine binding site [chemical binding]; other site 218491002752 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218491002753 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 218491002754 Integrase; Region: Integrase_1; pfam12835 218491002755 1 probable transmembrane helix predicted for ECA0589 by TMHMM2.0 at aa 51-73 218491002756 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 218491002757 MPN+ (JAMM) motif; other site 218491002758 Zinc-binding site [ion binding]; other site 218491002759 1 probable transmembrane helix predicted for ECA0594 by TMHMM2.0 at aa 51-70 218491002760 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 218491002761 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 218491002762 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 218491002763 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 218491002764 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 218491002765 NAD(P) binding site [chemical binding]; other site 218491002766 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 6.7e-64 218491002767 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 218491002768 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218491002769 CoenzymeA binding site [chemical binding]; other site 218491002770 subunit interaction site [polypeptide binding]; other site 218491002771 PHB binding site; other site 218491002772 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 218491002773 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 218491002774 active site 218491002775 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 218491002776 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 218491002777 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 218491002778 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 218491002779 putative NADP binding site [chemical binding]; other site 218491002780 active site 218491002781 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 218491002782 Thioesterase; Region: PKS_TE; smart00824 218491002783 HMMPfam hit to PF00975, DE Thioesterase domain, score 1e-15 218491002784 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 1.9e-17 218491002785 PS00012 Phosphopantetheine attachment site. 218491002786 HMMPfam hit to PF00698, DE Acyl transferase domain, score 2e-74 218491002787 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 1.7e-99 218491002788 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 1.1e-118 218491002789 PS00606 Beta-ketoacyl synthases active site. 218491002790 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 218491002791 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 218491002792 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 218491002793 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 218491002794 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 218491002795 active site 218491002796 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 218491002797 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 218491002798 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 218491002799 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 218491002800 Enoylreductase; Region: PKS_ER; smart00829 218491002801 NAD(P) binding site [chemical binding]; other site 218491002802 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 218491002803 putative NADP binding site [chemical binding]; other site 218491002804 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 218491002805 active site 218491002806 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 218491002807 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 8.2e-12 218491002808 PS00012 Phosphopantetheine attachment site. 218491002809 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 7.2e-78 218491002810 HMMPfam hit to PF00698, DE Acyl transferase domain, score 9e-113 218491002811 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 3.7e-97 218491002812 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 2.5e-127 218491002813 PS00606 Beta-ketoacyl synthases active site. 218491002814 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 1.2e-08 218491002815 HMMPfam hit to PF00698, DE Acyl transferase domain, score 3e-62 218491002816 AMP-binding enzyme; Region: AMP-binding; pfam00501 218491002817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491002818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491002819 acyl-activating enzyme (AAE) consensus motif; other site 218491002820 acyl-activating enzyme (AAE) consensus motif; other site 218491002821 active site 218491002822 AMP binding site [chemical binding]; other site 218491002823 CoA binding site [chemical binding]; other site 218491002824 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 2.4e-38 218491002825 2 probable transmembrane helices predicted for ECA0604 by TMHMM2.0 at aa 60-82 and 188-210 218491002826 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218491002827 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 218491002828 dimer interface [polypeptide binding]; other site 218491002829 active site 218491002830 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 1.4e-38 218491002831 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 6.2e-17 218491002832 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 218491002833 active site 2 [active] 218491002834 active site 1 [active] 218491002835 HMMPfam hit to PF01377, , score 3.2e-52 218491002836 Phosphopantetheine attachment site; Region: PP-binding; cl09936 218491002837 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 218491002838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491002839 acyl-activating enzyme (AAE) consensus motif; other site 218491002840 AMP binding site [chemical binding]; other site 218491002841 active site 218491002842 CoA binding site [chemical binding]; other site 218491002843 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 2.3e-67 218491002844 Predicted helix-turn-helix motif with score 1046.000, SD 2.75 at aa 184-205, sequence YSQKTLTDAINLTKATINPKLH 218491002845 PS00455 AMP-binding domain signature. 218491002846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491002847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491002848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491002849 dimerization interface [polypeptide binding]; other site 218491002850 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 8.5e-19 218491002851 Predicted helix-turn-helix motif with score 1463.000, SD 4.17 at aa 22-43, sequence QSFTLAASELFISQSAISKHIN 218491002852 PS00044 Bacterial regulatory proteins, lysR family signature. 218491002853 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 218491002854 Family description; Region: UvrD_C_2; pfam13538 218491002855 PS00017 ATP/GTP-binding site motif A (P-loop). 218491002856 DinB family; Region: DinB; cl17821 218491002857 DinB superfamily; Region: DinB_2; pfam12867 218491002858 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 218491002859 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 218491002860 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 218491002861 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 218491002862 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 218491002863 active site 218491002864 catalytic residues [active] 218491002865 DNA binding site [nucleotide binding] 218491002866 Int/Topo IB signature motif; other site 218491002867 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 0.0016 218491002868 HMMPfam hit to PF00589, DE Phage integrase family, score 1.2e-11 218491002869 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491002870 Helix-turn-helix domain; Region: HTH_18; pfam12833 218491002871 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.00053 218491002872 Predicted helix-turn-helix motif with score 1553.000, SD 4.48 at aa 188-209, sequence IGLSDLARETGTDRFTLTRCFK 218491002873 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.29 218491002874 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 218491002875 5 probable transmembrane helices predicted for ECA0616 by TMHMM2.0 at aa 4-26, 39-61, 71-88, 108-130 and 140-162 218491002876 putative transcriptional regulator; Provisional; Region: PRK11640 218491002877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491002878 Signal peptide predicted for ECA0618 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.736 between residues 23 and 24; signal peptide 218491002879 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 218491002880 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 218491002881 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 218491002882 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 218491002883 DsbD alpha interface [polypeptide binding]; other site 218491002884 catalytic residues [active] 218491002885 PS00194 Thioredoxin family active site. 218491002886 8 probable transmembrane helices predicted for ECA0618 by TMHMM2.0 at aa 5-27, 181-203, 223-245, 257-279, 306-328, 335-357, 367-389 and 396-418 218491002887 HMMPfam hit to PF02683, DE Cytochrome C biogenesis protein transmembrane region, score 1.5e-06 218491002888 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 218491002889 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03091, DE CutA1 divalent ion tolerance protein, score 3.9e-48 218491002890 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 218491002891 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 218491002892 11 probable transmembrane helices predicted for ECA0620 by TMHMM2.0 at aa 15-37, 44-66, 88-110, 131-153, 163-185, 229-251, 261-279, 284-306, 326-345, 358-380 and 410-432 218491002893 HMMPfam hit to PF03605, DE Anaerobic c4-dicarboxylate membrane transporter, score 1.1e-232 218491002894 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 218491002895 Aspartase; Region: Aspartase; cd01357 218491002896 active sites [active] 218491002897 tetramer interface [polypeptide binding]; other site 218491002898 HMMPfam hit to PF00206, DE Lyase, score 3.8e-206 218491002899 PS00163 Fumarate lyases signature. 218491002900 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 218491002901 3 probable transmembrane helices predicted for ECA0623 by TMHMM2.0 at aa 7-24, 28-47 and 79-101 218491002902 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 218491002903 oligomerisation interface [polypeptide binding]; other site 218491002904 mobile loop; other site 218491002905 roof hairpin; other site 218491002906 HMMPfam hit to PF00166, DE Chaperonin 10 Kd subunit, score 8.2e-52 218491002907 PS00681 Chaperonins cpn10 signature. 218491002908 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 218491002909 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 218491002910 ring oligomerisation interface [polypeptide binding]; other site 218491002911 ATP/Mg binding site [chemical binding]; other site 218491002912 stacking interactions; other site 218491002913 hinge regions; other site 218491002914 HMMPfam hit to PF00118, DE TCP-1/cpn60 chaperonin family, score 2.1e-182 218491002915 PS00296 Chaperonins cpn60 signature. 218491002916 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 218491002917 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 218491002918 UbiA prenyltransferase family; Region: UbiA; pfam01040 218491002919 7 probable transmembrane helices predicted for ECA0627 by TMHMM2.0 at aa 23-40, 45-67, 102-124, 139-161, 168-190, 205-227 and 234-256 218491002920 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01040, DE UbiA prenyltransferase family, score 7.5e-75 218491002921 PS00943 UbiA prenyltransferase family signature. 218491002922 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 218491002923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 218491002924 putative acyl-acceptor binding pocket; other site 218491002925 HMMPfam hit to PF01553, DE Acyltransferase, score 2.7e-38 218491002926 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 218491002927 HMMPfam hit to PF01219, DE Prokaryotic diacylglycerol kinase, score 8.2e-48 218491002928 3 probable transmembrane helices predicted for ECA0629 by TMHMM2.0 at aa 36-53, 57-79 and 96-118 218491002929 LexA repressor; Validated; Region: PRK00215 218491002930 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 218491002931 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 218491002932 Catalytic site [active] 218491002933 HMMPfam hit to PF01726, DE LexA DNA binding domain, score 1.3e-35 218491002934 HMMPfam hit to PF00717, DE Peptidase family S24, score 6.6e-56 218491002935 hypothetical protein; Provisional; Region: PRK10428 218491002936 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 218491002937 metal binding site 2 [ion binding]; metal-binding site 218491002938 putative DNA binding helix; other site 218491002939 metal binding site 1 [ion binding]; metal-binding site 218491002940 dimer interface [polypeptide binding]; other site 218491002941 structural Zn2+ binding site [ion binding]; other site 218491002942 HMMPfam hit to PF01475, DE Ferric uptake regulator family, score 9e-06 218491002943 Pirin-related protein [General function prediction only]; Region: COG1741 218491002944 Pirin; Region: Pirin; pfam02678 218491002945 HMMPfam hit to PF02678, DE Pirin, score 6.8e-98 218491002946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491002947 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 218491002948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491002949 dimerization interface [polypeptide binding]; other site 218491002950 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 8.4e-21 218491002951 Predicted helix-turn-helix motif with score 1071.000, SD 2.83 at aa 22-43, sequence GSFAAAADELGRVPSALSYTMQ 218491002952 PS00044 Bacterial regulatory proteins, lysR family signature. 218491002953 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 2.5e-15 218491002954 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 218491002955 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 218491002956 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 218491002957 putative dimer interface [polypeptide binding]; other site 218491002958 N-terminal domain interface [polypeptide binding]; other site 218491002959 putative substrate binding pocket (H-site) [chemical binding]; other site 218491002960 Predicted membrane protein [Function unknown]; Region: COG2259 218491002961 4 probable transmembrane helices predicted for ECA0636 by TMHMM2.0 at aa 9-28, 43-65, 72-91 and 106-128 218491002962 YqjK-like protein; Region: YqjK; pfam13997 218491002963 Predicted membrane protein [Function unknown]; Region: COG5393 218491002964 2 probable transmembrane helices predicted for ECA0638 by TMHMM2.0 at aa 49-71 and 81-103 218491002965 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 218491002966 1 probable transmembrane helix predicted for ECA0639 by TMHMM2.0 at aa 81-98 218491002967 Signal peptide predicted for ECA0640 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.892 between residues 20 and 21; signal peptide 218491002968 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 218491002969 Signal peptide predicted for ECA0641 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.429 between residues 32 and 33; signal peptide 218491002970 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 218491002971 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218491002972 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218491002973 5 probable transmembrane helices predicted for ECA0642 by TMHMM2.0 at aa 24-46, 53-75, 126-148, 153-175 and 190-212 218491002974 HMMPfam hit to PF00597, DE DedA family, score 2.6e-54 218491002975 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 218491002976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491002977 DNA-binding site [nucleotide binding]; DNA binding site 218491002978 FCD domain; Region: FCD; pfam07729 218491002979 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 2.8e-27 218491002980 PS00043 Bacterial regulatory proteins, gntR family signature. 218491002981 Signal peptide predicted for ECA0644 by SignalP 2.0 HMM (Signal peptide probabilty 0.905) with cleavage site probability 0.656 between residues 32 and 33; signal peptide 218491002982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491002983 D-galactonate transporter; Region: 2A0114; TIGR00893 218491002984 putative substrate translocation pore; other site 218491002985 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0034 218491002986 12 probable transmembrane helices predicted for ECA0644 by TMHMM2.0 at aa 7-29, 47-69, 76-98, 102-124, 137-159, 163-185, 233-255, 265-287, 300-322, 327-349, 362-384 and 389-411 218491002987 Glucuronate isomerase; Region: UxaC; pfam02614 218491002988 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 218491002989 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02614, DE Glucuronate isomerase, score 0 218491002990 altronate oxidoreductase; Provisional; Region: PRK03643 218491002991 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218491002992 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218491002993 HMMPfam hit to PF01232, DE Mannitol dehydrogenase, score 7.5e-125 218491002994 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 218491002995 galactarate dehydratase; Region: galactar-dH20; TIGR03248 218491002996 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 218491002997 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 218491002998 5 probable transmembrane helices predicted for ECA0648 by TMHMM2.0 at aa 4-23, 36-58, 73-90, 97-119 and 134-156 218491002999 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 218491003000 Mg2+ binding site [ion binding]; other site 218491003001 G-X-G motif; other site 218491003002 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 218491003003 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 0.058 218491003004 2 probable transmembrane helices predicted for ECA0650 by TMHMM2.0 at aa 43-65 and 118-140 218491003005 serine/threonine transporter SstT; Provisional; Region: PRK13628 218491003006 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218491003007 HMMPfam hit to PF00375, DE Sodium:dicarboxylate symporter family, score 4.9e-143 218491003008 8 probable transmembrane helices predicted for ECA0651 by TMHMM2.0 at aa 35-57, 62-84, 97-119, 154-176, 196-218, 228-250, 301-323 and 343-365 218491003009 PS00435 Peroxidases proximal heme-ligand signature. 218491003010 Signal peptide predicted for ECA0651 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.795 between residues 55 and 56 218491003011 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 218491003012 9 probable transmembrane helices predicted for ECA0652 by TMHMM2.0 at aa 40-62, 75-97, 122-141, 148-170, 176-195, 232-254, 269-291, 298-320 and 324-346 218491003013 HMMPfam hit to PF03741, DE Integral membrane protein TerC family, score 3e-94 218491003014 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491003015 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491003016 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 1.1e-40 218491003017 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 218491003018 Methyltransferase small domain; Region: MTS; pfam05175 218491003019 S-adenosylmethionine binding site [chemical binding]; other site 218491003020 PS00092 N-6 Adenine-specific DNA methylases signature. 218491003021 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491003022 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 218491003023 active site 218491003024 FMN binding site [chemical binding]; other site 218491003025 2,4-decadienoyl-CoA binding site; other site 218491003026 catalytic residue [active] 218491003027 4Fe-4S cluster binding site [ion binding]; other site 218491003028 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 218491003029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491003030 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 1.9e-07 218491003031 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491003032 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 2.1e-130 218491003033 Signal peptide predicted for ECA0658 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 23 and 24; signal peptide 218491003034 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 218491003035 dimer interface [polypeptide binding]; other site 218491003036 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491003037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491003038 metal binding site [ion binding]; metal-binding site 218491003039 active site 218491003040 I-site; other site 218491003041 9 probable transmembrane helices predicted for ECA0659 by TMHMM2.0 at aa 13-32, 36-53, 66-85, 95-112, 133-155, 170-187, 208-230, 245-267 and 280-302 218491003042 HMMPfam hit to PF00990, DE GGDEF domain, score 1.9e-55 218491003043 Signal peptide predicted for ECA0660 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 21 and 22; signal peptide 218491003044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 218491003045 HMMPfam hit to PF03713, DE Domain of unknown function, score 2.6e-27 218491003046 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 218491003047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491003048 active site turn [active] 218491003049 phosphorylation site [posttranslational modification] 218491003050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491003051 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 218491003052 HPr interaction site; other site 218491003053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218491003054 active site 218491003055 phosphorylation site [posttranslational modification] 218491003056 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 5.9e-14 218491003057 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491003058 10 probable transmembrane helices predicted for ECA0661 by TMHMM2.0 at aa 125-147, 162-184, 191-210, 220-242, 262-284, 304-326, 339-361, 371-393, 398-420 and 440-462 218491003059 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 7.5e-17 218491003060 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491003061 HMMPfam hit to PF00358, DE phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 5e-58 218491003062 PS00371 PTS EIIA domains phosphorylation site signature 1. 218491003063 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218491003064 beta-galactosidase; Region: BGL; TIGR03356 218491003065 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 2.1e-191 218491003066 PS00572 Glycosyl hydrolases family 1 active site. 218491003067 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491003068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491003069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491003070 phage genes 218491003071 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491003072 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 218491003073 active site 218491003074 Int/Topo IB signature motif; other site 218491003075 DNA binding site [nucleotide binding] 218491003076 HMMPfam hit to PF00589, DE Phage integrase family, score 3.1e-07 218491003077 Helix-turn-helix domain; Region: HTH_17; pfam12728 218491003078 Predicted helix-turn-helix motif with score 1571.000, SD 4.54 at aa 7-28, sequence MTRKEAAAYIGVNPATMANWAS 218491003079 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 218491003080 active site 218491003081 metal binding site [ion binding]; metal-binding site 218491003082 interdomain interaction site; other site 218491003083 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 218491003084 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003085 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491003086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491003087 salt bridge; other site 218491003088 non-specific DNA binding site [nucleotide binding]; other site 218491003089 sequence-specific DNA binding site [nucleotide binding]; other site 218491003090 HMMPfam hit to PF01381, DE Helix-turn-helix, score 1.6e-11 218491003091 Predicted helix-turn-helix motif with score 2194.000, SD 6.66 at aa 77-98, sequence MTQKQVAEKLGIKQSTVSEFEK 218491003092 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 218491003093 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01919, DE Protein of unknown function DUF79, score 7.4e-05 218491003094 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218491003095 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218491003096 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 218491003097 active site 218491003098 SUMO-1 interface [polypeptide binding]; other site 218491003099 HMMPfam hit to PF03167, DE Uracil DNA glycosylase superfamily, score 1.5e-21 218491003100 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 218491003101 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 218491003102 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218491003103 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 218491003104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491003105 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218491003106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491003107 DNA binding residues [nucleotide binding] 218491003108 HMMPfam hit to PF00140, DE Sigma-70 factor, region 1.2, score 8.5e-135 218491003109 PS00716 Sigma-70 factors family signature 2. 218491003110 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 569-590, sequence HTLEEVGKQFDVTRERIRQIEA 218491003111 PS00715 Sigma-70 factors family signature 1. 218491003112 DNA primase; Validated; Region: dnaG; PRK05667 218491003113 CHC2 zinc finger; Region: zf-CHC2; pfam01807 218491003114 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491003115 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218491003116 active site 218491003117 metal binding site [ion binding]; metal-binding site 218491003118 interdomain interaction site; other site 218491003119 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 218491003120 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 218491003121 HMMPfam hit to PF01751, DE Toprim domain, score 3.6e-25 218491003122 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 1.7e-64 218491003123 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 218491003124 HMMPfam hit to PF01165, DE Ribosomal protein S21, score 1.9e-34 218491003125 PS01181 Ribosomal protein S21 signature. 218491003126 UGMP family protein; Validated; Region: PRK09604 218491003127 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 218491003128 HMMPfam hit to PF00814, DE Glycoprotease family, score 1.2e-186 218491003129 arginine repressor; Provisional; Region: PRK05066 218491003130 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 218491003131 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 218491003132 HMMPfam hit to PF02863, DE Arginine repressor, C-terminal domain, score 7.7e-35 218491003133 HMMPfam hit to PF01316, DE Arginine repressor, DNA binding domain, score 1.1e-32 218491003134 malate dehydrogenase; Provisional; Region: PRK05086 218491003135 Signal peptide predicted for ECA0685 by SignalP 2.0 HMM (Signal peptide probabilty 0.803) with cleavage site probability 0.736 between residues 17 and 18; signal peptide 218491003136 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 218491003137 NAD binding site [chemical binding]; other site 218491003138 dimerization interface [polypeptide binding]; other site 218491003139 Substrate binding site [chemical binding]; other site 218491003140 HMMPfam hit to PF00056, DE lactate/malate dehydrogenase, NAD binding domain, score 2.9e-65 218491003141 PS00068 Malate dehydrogenase active site signature. 218491003142 HMMPfam hit to PF02866, DE lactate/malate dehydrogenase, alpha/beta C-terminal domain, score 3.9e-62 218491003143 Signal peptide predicted for ECA0686 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.656 between residues 39 and 40; signal peptide 218491003144 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 218491003145 Predicted helix-turn-helix motif with score 1474.000, SD 4.21 at aa 22-43, sequence TTLAAVSRAAGLSSSTLANALS 218491003146 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 218491003147 HMMPfam hit to PF02316, DE Mu DNA-binding domain, score 0.0029 218491003148 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 218491003149 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218491003150 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218491003151 substrate binding pocket [chemical binding]; other site 218491003152 chain length determination region; other site 218491003153 substrate-Mg2+ binding site; other site 218491003154 catalytic residues [active] 218491003155 aspartate-rich region 1; other site 218491003156 active site lid residues [active] 218491003157 aspartate-rich region 2; other site 218491003158 HMMPfam hit to PF00348, DE Polyprenyl synthetase, score 1.2e-116 218491003159 PS00444 Polyprenyl synthetases signature 2. 218491003160 PS00723 Polyprenyl synthetases signature 1. 218491003161 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 218491003162 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 218491003163 HMMPfam hit to PF00829, DE Ribosomal prokaryotic L21 protein, score 4.8e-54 218491003164 PS01169 Ribosomal protein L21 signature. 218491003165 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 218491003166 HMMPfam hit to PF01016, DE Ribosomal L27 protein, score 1.3e-57 218491003167 PS00831 Ribosomal protein L27 signature. 218491003168 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218491003169 EamA-like transporter family; Region: EamA; pfam00892 218491003170 10 probable transmembrane helices predicted for ECA0692 by TMHMM2.0 at aa 7-25, 40-57, 73-95, 105-122, 131-153, 157-179, 192-207, 217-239, 251-273 and 283-302 218491003171 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 5.4e-27 218491003172 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 1.2e-11 218491003173 GTPase CgtA; Reviewed; Region: obgE; PRK12298 218491003174 GTP1/OBG; Region: GTP1_OBG; pfam01018 218491003175 Obg GTPase; Region: Obg; cd01898 218491003176 G1 box; other site 218491003177 GTP/Mg2+ binding site [chemical binding]; other site 218491003178 Switch I region; other site 218491003179 G2 box; other site 218491003180 G3 box; other site 218491003181 Switch II region; other site 218491003182 G4 box; other site 218491003183 G5 box; other site 218491003184 HMMPfam hit to PF01018, DE GTP1/OBG family, score 3.6e-132 218491003185 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003186 PS00905 GTP1/OBG family signature. 218491003187 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 218491003188 Signal peptide predicted for ECA0694 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.895 between residues 20 and 21; signal peptide 218491003189 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 218491003190 HMMPfam hit to PF02113, DE D-Ala-D-Ala carboxypeptidase 3 (S13) family, score 8.2e-190 218491003191 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 218491003192 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 218491003193 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218491003194 HMMPfam hit to PF03449, DE Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain, score 2.3e-46 218491003195 PS00829 Prokaryotic transcription elongation factors signature 1. 218491003196 HMMPfam hit to PF01272, DE Prokaryotic transcription elongation factor, GreA/GreB, C-terminal domain, score 4e-42 218491003197 PS00830 Prokaryotic transcription elongation factors signature 2. 218491003198 RNA-binding protein YhbY; Provisional; Region: PRK10343 218491003199 HMMPfam hit to PF01985, DE Uncharacterised protein family UPF0044, score 9.7e-05 218491003200 PS01301 Uncharacterized protein family UPF0044 signature. 218491003201 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 218491003202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491003203 S-adenosylmethionine binding site [chemical binding]; other site 218491003204 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01728, DE FtsJ-like methyltransferase, score 6.1e-76 218491003205 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 218491003206 Signal peptide predicted for ECA0698 by SignalP 2.0 HMM (Signal peptide probabilty 0.768) with cleavage site probability 0.534 between residues 26 and 27; signal peptide 218491003207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491003208 Walker A motif; other site 218491003209 ATP binding site [chemical binding]; other site 218491003210 Walker B motif; other site 218491003211 arginine finger; other site 218491003212 Peptidase family M41; Region: Peptidase_M41; pfam01434 218491003213 2 probable transmembrane helices predicted for ECA0698 by TMHMM2.0 at aa 7-26 and 100-122 218491003214 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003215 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 2.3e-96 218491003216 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003217 PS00674 AAA-protein family signature. 218491003218 HMMPfam hit to PF01434, DE Peptidase family M41, score 1e-124 218491003219 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 218491003220 dihydropteroate synthase; Region: DHPS; TIGR01496 218491003221 substrate binding pocket [chemical binding]; other site 218491003222 dimer interface [polypeptide binding]; other site 218491003223 inhibitor binding site; inhibition site 218491003224 PS00792 Dihydropteroate synthase signature 1. 218491003225 HMMPfam hit to PF00809, DE Pterin binding enzyme, score 1.9e-120 218491003226 PS00793 Dihydropteroate synthase signature 2. 218491003227 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 218491003228 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 218491003229 active site 218491003230 substrate binding site [chemical binding]; other site 218491003231 metal binding site [ion binding]; metal-binding site 218491003232 HMMPfam hit to PF02878, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 4.7e-60 218491003233 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218491003234 HMMPfam hit to PF02879, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 6.9e-47 218491003235 HMMPfam hit to PF02880, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 1.1e-37 218491003236 HMMPfam hit to PF00408, DE Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 1.1e-10 218491003237 Preprotein translocase SecG subunit; Region: SecG; pfam03840 218491003238 HMMPfam hit to PF03840, DE Preprotein translocase SecG subunit, score 5.9e-33 218491003239 2 probable transmembrane helices predicted for ECA0702 by TMHMM2.0 at aa 5-22 and 51-73 218491003240 Similar to Ralstonia solanacearum probable NADP-dependent oxidoreductase rsc1766 SWALL:Q8XYJ2 (EMBL:AL646066) (336 aa) fasta scores: E(): 1.3e-09, 33.1% id in 145 aa, and to Escherichia coli NADP-dependent oxidoreductase YncB SWALL:YNCB_ECOLI (SWALL:P76113) (353 aa) fasta scores: E(): 7.4e-08, 31.94% id in 144 aa. Probable pseudogene arising from frameshift mutation after amino acid residue 82.; oxidoreductase (pseudogene) 218491003241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491003242 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491003243 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 218491003244 Pseudogene. Similar to Pectobacterium carotovorum subsp. carotovorum probable lysozyme SWALL:Q8GCR0 (EMBL:AY167733) (86 aa) fasta scores: E(): 7.2e-15, 63.75% id in 80 aa, and to Bacteriophage APSE-1 probable lysozyme 13 SWALL:LYCV_BPAPS (SWALL:Q9T1T5) (146 aa) fasta scores: E(): 1.4e-11, 34.84% id in 132 aa; phage-related lysozyme (pseudogene) 218491003245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218491003246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491003247 DNA binding residues [nucleotide binding] 218491003248 dimerization interface [polypeptide binding]; other site 218491003249 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 3.3e-13 218491003250 PS00622 Bacterial regulatory proteins, luxR family signature. 218491003251 Predicted helix-turn-helix motif with score 1141.000, SD 3.07 at aa 71-92, sequence ASNKQISRTLNISAGTVKSHLE 218491003252 ribosome maturation protein RimP; Reviewed; Region: PRK00092 218491003253 Sm and related proteins; Region: Sm_like; cl00259 218491003254 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 218491003255 putative oligomer interface [polypeptide binding]; other site 218491003256 putative RNA binding site [nucleotide binding]; other site 218491003257 HMMPfam hit to PF02576, DE Uncharacterised BCR, YhbC family COG0779, score 4.4e-73 218491003258 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 218491003259 NusA N-terminal domain; Region: NusA_N; pfam08529 218491003260 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 218491003261 RNA binding site [nucleotide binding]; other site 218491003262 homodimer interface [polypeptide binding]; other site 218491003263 NusA-like KH domain; Region: KH_5; pfam13184 218491003264 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 218491003265 G-X-X-G motif; other site 218491003266 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 218491003267 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 218491003268 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218491003269 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 218491003270 translation initiation factor IF-2; Region: IF-2; TIGR00487 218491003271 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218491003272 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 218491003273 G1 box; other site 218491003274 putative GEF interaction site [polypeptide binding]; other site 218491003275 GTP/Mg2+ binding site [chemical binding]; other site 218491003276 Switch I region; other site 218491003277 G2 box; other site 218491003278 G3 box; other site 218491003279 Switch II region; other site 218491003280 G4 box; other site 218491003281 G5 box; other site 218491003282 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 218491003283 Translation-initiation factor 2; Region: IF-2; pfam11987 218491003284 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 218491003285 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 4.7e-53 218491003286 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003287 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 2.2e-13 218491003288 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 1.8e-12 218491003289 PS01176 Initiation factor 2 signature. 218491003290 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 218491003291 HMMPfam hit to PF02033, DE Ribosome-binding factor A, score 9.4e-54 218491003292 PS01319 Ribosome-binding factor A signature. 218491003293 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 218491003294 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 218491003295 RNA binding site [nucleotide binding]; other site 218491003296 active site 218491003297 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 218491003298 HMMPfam hit to PF01509, DE TruB family pseudouridylate synthase (N terminal domain), score 1.1e-85 218491003299 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 218491003300 16S/18S rRNA binding site [nucleotide binding]; other site 218491003301 S13e-L30e interaction site [polypeptide binding]; other site 218491003302 25S rRNA binding site [nucleotide binding]; other site 218491003303 HMMPfam hit to PF00312, DE Ribosomal protein S15, score 1.1e-44 218491003304 PS00362 Ribosomal protein S15 signature. 218491003305 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 218491003306 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 218491003307 RNase E interface [polypeptide binding]; other site 218491003308 trimer interface [polypeptide binding]; other site 218491003309 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 218491003310 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 218491003311 RNase E interface [polypeptide binding]; other site 218491003312 trimer interface [polypeptide binding]; other site 218491003313 active site 218491003314 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 218491003315 putative nucleic acid binding region [nucleotide binding]; other site 218491003316 G-X-X-G motif; other site 218491003317 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 218491003318 RNA binding site [nucleotide binding]; other site 218491003319 domain interface; other site 218491003320 HMMPfam hit to PF01138, DE 3' exoribonuclease family, domain 1, score 6.9e-42 218491003321 HMMPfam hit to PF03725, DE 3' exoribonuclease family, domain 2, score 1.1e-15 218491003322 HMMPfam hit to PF03726, DE Polyribonucleotide nucleotidyltransferase, RNA binding domain, score 3.9e-32 218491003323 HMMPfam hit to PF01138, DE 3' exoribonuclease family, domain 1, score 5.5e-53 218491003324 HMMPfam hit to PF03725, DE 3' exoribonuclease family, domain 2, score 6e-21 218491003325 HMMPfam hit to PF00013, DE KH domain, score 1.7e-09 218491003326 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 3.5e-27 218491003327 lipoprotein NlpI; Provisional; Region: PRK11189 218491003328 Signal peptide predicted for ECA0717 by SignalP 2.0 HMM (Signal peptide probabilty 0.824) with cleavage site probability 0.567 between residues 25 and 26; signal peptide 218491003329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491003330 binding surface 218491003331 TPR motif; other site 218491003332 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003333 HMMPfam hit to PF00515, DE TPR Domain, score 0.0015 218491003334 HMMPfam hit to PF00515, DE TPR Domain, score 0.00011 218491003335 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218491003336 DEAD-like helicases superfamily; Region: DEXDc; smart00487 218491003337 ATP binding site [chemical binding]; other site 218491003338 Mg++ binding site [ion binding]; other site 218491003339 motif III; other site 218491003340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491003341 nucleotide binding region [chemical binding]; other site 218491003342 ATP-binding site [chemical binding]; other site 218491003343 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 218491003344 putative RNA binding site [nucleotide binding]; other site 218491003345 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 2.3e-87 218491003346 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003347 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491003348 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 3.6e-32 218491003349 HMMPfam hit to PF03880, DE DbpA RNA binding domain, score 1.9e-38 218491003350 Pseudogene. This CDS appears to have a frameshift mutation following codon 177. Similar to Yersinia pestis hypothetical protein ypo3484 or y0700 SWALL:Q8ZBD2 (EMBL:AJ414157) (351 aa) fasta scores: E(): 8.3e-103, 80.67% id in 326 aa, and to Escherichia coli O157:H7 enzyme yhbw or z4521 or ecs4041 SWALL:Q8XA89 (EMBL:AE005544) (335 aa) fasta scores: E(): 3.2e-92, 70.6% id in 330 aa;conserved hypothetical protein (pseudogene) 218491003351 HMMPfam hit to PF00296, DE Luciferase-like monooxygenase, score 3.5e-06 218491003352 putative protease; Provisional; Region: PRK15447 218491003353 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 218491003354 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 218491003355 Peptidase family U32; Region: Peptidase_U32; pfam01136 218491003356 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01136, DE Peptidase family U32, score 2.2e-143 218491003357 PS01276 Peptidase family U32 signature. 218491003358 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 218491003359 HMMPfam hit to PF02036, DE SCP-2 sterol transfer family, score 1.3e-21 218491003360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491003361 Coenzyme A binding pocket [chemical binding]; other site 218491003362 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 4.1e-10 218491003363 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 218491003364 GIY-YIG motif/motif A; other site 218491003365 putative active site [active] 218491003366 putative metal binding site [ion binding]; other site 218491003367 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 218491003368 intersubunit interface [polypeptide binding]; other site 218491003369 active site 218491003370 catalytic residue [active] 218491003371 HMMPfam hit to PF01791, DE Deoxyribose-phosphate aldolase, score 3.5e-85 218491003372 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003373 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 218491003374 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218491003375 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 218491003376 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 218491003377 HMMPfam hit to PF02885, DE Glycosyl transferase family, helical bundle domain, score 7.9e-23 218491003378 HMMPfam hit to PF00591, DE Glycosyl transferase family, a/b domain, score 1.2e-71 218491003379 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003380 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 218491003381 phosphopentomutase; Provisional; Region: PRK05362 218491003382 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 218491003383 HMMPfam hit to PF01676, DE Metalloenzyme superfamily, score 1.4e-41 218491003384 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 218491003385 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 218491003386 HMMPfam hit to PF01048, DE Phosphorylase family, score 1e-112 218491003387 PS01232 Purine and other phosphorylases family 1 signature. 218491003388 Signal peptide predicted for ECA0731 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 34 and 35; signal peptide 218491003389 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491003390 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491003391 N-terminal plug; other site 218491003392 ligand-binding site [chemical binding]; other site 218491003393 PS00430 TonB-dependent receptor proteins signature 1. 218491003394 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 1.8e-27 218491003395 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491003396 Signal peptide predicted for ECA0732 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.971 between residues 21 and 22; signal peptide 218491003397 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 218491003398 sugar binding site [chemical binding]; other site 218491003399 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 218491003400 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 218491003401 Coenzyme A binding pocket [chemical binding]; other site 218491003402 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.8e-23 218491003403 DNA polymerase III subunit psi; Validated; Region: PRK06856 218491003404 HMMPfam hit to PF03603, DE DNA polymerase III psi subunit, score 1e-36 218491003405 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 218491003406 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 218491003407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491003408 S-adenosylmethionine binding site [chemical binding]; other site 218491003409 PS00092 N-6 Adenine-specific DNA methylases signature. 218491003410 Signal peptide predicted for ECA0736 by SignalP 2.0 HMM (Signal peptide probabilty 0.732) with cleavage site probability 0.727 between residues 30 and 31; signal peptide 218491003411 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491003412 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491003413 active site 218491003414 catalytic tetrad [active] 218491003415 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 1.7e-75 218491003416 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491003417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491003418 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 218491003419 putative effector binding pocket; other site 218491003420 putative dimerization interface [polypeptide binding]; other site 218491003421 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.4e-21 218491003422 Predicted helix-turn-helix motif with score 1387.000, SD 3.91 at aa 21-42, sequence GSFSRAAERLALPRATVSNTIK 218491003423 PS00044 Bacterial regulatory proteins, lysR family signature. 218491003424 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 3.3e-36 218491003425 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 218491003426 3 probable transmembrane helices predicted for ECA0738 by TMHMM2.0 at aa 21-40, 45-64 and 71-93 218491003427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491003428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491003429 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 218491003430 putative dimerization interface [polypeptide binding]; other site 218491003431 putative substrate binding pocket [chemical binding]; other site 218491003432 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.3e-42 218491003433 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 7.8e-30 218491003434 PS00044 Bacterial regulatory proteins, lysR family signature. 218491003435 Predicted helix-turn-helix motif with score 1765.000, SD 5.20 at aa 16-37, sequence RHFTRAAENLGMSQPPLSQQIK 218491003436 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 218491003437 HMMPfam hit to PF03306, DE Alpha-acetolactate decarboxylase, score 6.1e-120 218491003438 acetolactate synthase; Reviewed; Region: PRK08617 218491003439 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491003440 PYR/PP interface [polypeptide binding]; other site 218491003441 dimer interface [polypeptide binding]; other site 218491003442 TPP binding site [chemical binding]; other site 218491003443 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491003444 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 218491003445 TPP-binding site [chemical binding]; other site 218491003446 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 7.1e-72 218491003447 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 3.3e-34 218491003448 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 2.4e-63 218491003449 PS00187 Thiamine pyrophosphate enzymes signature. 218491003450 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 218491003451 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 218491003452 dimer interface [polypeptide binding]; other site 218491003453 active site 218491003454 metal binding site [ion binding]; metal-binding site 218491003455 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 2.2e-179 218491003456 PS00060 Iron-containing alcohol dehydrogenases signature 2. 218491003457 PS00913 Iron-containing alcohol dehydrogenases signature 1. 218491003458 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 218491003459 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 218491003460 HMMPfam hit to PF01571, DE Glycine cleavage T-protein (aminomethyl transferase), score 3.5e-148 218491003461 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 218491003462 lipoyl attachment site [posttranslational modification]; other site 218491003463 HMMPfam hit to PF01597, DE Glycine cleavage H-protein, score 9.5e-69 218491003464 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218491003465 glycine dehydrogenase; Provisional; Region: PRK05367 218491003466 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 218491003467 tetramer interface [polypeptide binding]; other site 218491003468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491003469 catalytic residue [active] 218491003470 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 218491003471 tetramer interface [polypeptide binding]; other site 218491003472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491003473 catalytic residue [active] 218491003474 HMMPfam hit to PF02347, DE Glycine cleavage system P-protein, score 1.3e-266 218491003475 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003476 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491003477 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491003478 HMMPfam hit to PF01638, DE Transcriptional regulator, score 3.9e-23 218491003479 1 probable transmembrane helix predicted for ECA0746 by TMHMM2.0 at aa 20-42 218491003480 short chain dehydrogenase; Provisional; Region: PRK06500 218491003481 classical (c) SDRs; Region: SDR_c; cd05233 218491003482 NAD(P) binding site [chemical binding]; other site 218491003483 active site 218491003484 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 9.4e-64 218491003485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491003486 dimer interface [polypeptide binding]; other site 218491003487 conserved gate region; other site 218491003488 putative PBP binding loops; other site 218491003489 ABC-ATPase subunit interface; other site 218491003490 6 probable transmembrane helices predicted for ECA0748 by TMHMM2.0 at aa 5-27, 69-91, 103-125, 154-176, 197-219 and 260-282 218491003491 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 8.4e-14 218491003492 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491003493 Signal peptide predicted for ECA0749 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.795 between residues 60 and 61; signal peptide 218491003494 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218491003495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491003496 dimer interface [polypeptide binding]; other site 218491003497 conserved gate region; other site 218491003498 putative PBP binding loops; other site 218491003499 ABC-ATPase subunit interface; other site 218491003500 6 probable transmembrane helices predicted for ECA0749 by TMHMM2.0 at aa 33-55, 99-121, 128-147, 162-184, 205-227 and 263-285 218491003501 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.8e-12 218491003502 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491003503 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 218491003504 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218491003505 active site 218491003506 metal binding site [ion binding]; metal-binding site 218491003507 hexamer interface [polypeptide binding]; other site 218491003508 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 2.5e-14 218491003509 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 218491003510 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218491003511 Walker A/P-loop; other site 218491003512 ATP binding site [chemical binding]; other site 218491003513 Q-loop/lid; other site 218491003514 ABC transporter signature motif; other site 218491003515 Walker B; other site 218491003516 D-loop; other site 218491003517 H-loop/switch region; other site 218491003518 TOBE domain; Region: TOBE_2; pfam08402 218491003519 HMMPfam hit to PF00005, DE ABC transporter, score 5.9e-62 218491003520 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003521 PS00211 ABC transporters family signature. 218491003522 Signal peptide predicted for ECA0752 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22; signal peptide 218491003523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 218491003524 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 218491003525 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 5.5e-41 218491003526 galactoside permease; Reviewed; Region: lacY; PRK09528 218491003527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491003528 putative substrate translocation pore; other site 218491003529 HMMPfam hit to PF01306, DE LacY proton/sugar symporter, score 1.1e-265 218491003530 11 probable transmembrane helices predicted for ECA0753 by TMHMM2.0 at aa 13-35, 50-72, 81-103, 108-130, 150-169, 173-192, 227-244, 286-308, 320-342, 352-374 and 387-406 218491003531 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 218491003532 Melibiase; Region: Melibiase; pfam02065 218491003533 PS00697 ATP-dependent DNA ligase AMP-binding site. 218491003534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491003535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491003536 DNA binding site [nucleotide binding] 218491003537 domain linker motif; other site 218491003538 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 218491003539 ligand binding site [chemical binding]; other site 218491003540 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 1.3e-38 218491003541 Predicted helix-turn-helix motif with score 1661.000, SD 4.84 at aa 1-22, sequence MSLKTIANNLGLSVTAVSRALN 218491003542 HD domain; Region: HD_3; pfam13023 218491003543 HMMPfam hit to PF01966, DE HD domain, score 0.00094 218491003544 hemolysin; Provisional; Region: PRK15087 218491003545 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 218491003546 HMMPfam hit to PF03006, DE Uncharacterised protein family (Hly-III / UPF0073), score 0.0019 218491003547 7 probable transmembrane helices predicted for ECA0757 by TMHMM2.0 at aa 35-57, 72-94, 107-125, 130-152, 157-179, 183-205 and 212-233 218491003548 putative global regulator; Reviewed; Region: PRK09559 218491003549 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 218491003550 hypothetical protein; Provisional; Region: PRK10878 218491003551 HMMPfam hit to PF03937, DE TPR repeat region, score 5.2e-29 218491003552 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 218491003553 2 probable transmembrane helices predicted for ECA0760 by TMHMM2.0 at aa 12-34 and 38-55 218491003554 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 218491003555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491003556 S-adenosylmethionine binding site [chemical binding]; other site 218491003557 Signal peptide predicted for ECA0762 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.905 between residues 19 and 20; signal peptide 218491003558 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003559 flavodoxin FldB; Provisional; Region: PRK12359 218491003560 HMMPfam hit to PF00258, DE Flavodoxin, score 8.6e-38 218491003561 PS00201 Flavodoxin signature. 218491003562 Signal peptide predicted for ECA0765 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 23 and 24; signal peptide 218491003563 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 218491003564 Signal peptide predicted for ECA0766 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.991 between residues 21 and 22; signal peptide 218491003565 Signal peptide predicted for ECA0767 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.950 between residues 22 and 23; signal peptide 218491003566 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 218491003567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491003568 metabolite-proton symporter; Region: 2A0106; TIGR00883 218491003569 putative substrate translocation pore; other site 218491003570 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 5.1e-79 218491003571 11 probable transmembrane helices predicted for ECA0769 by TMHMM2.0 at aa 25-47, 67-89, 110-132, 167-189, 196-218, 248-270, 290-312, 322-341, 348-370, 380-402 and 409-431 218491003572 PS00216 Sugar transport proteins signature 1. 218491003573 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 218491003574 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 218491003575 active site 218491003576 Int/Topo IB signature motif; other site 218491003577 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 3.7e-30 218491003578 HMMPfam hit to PF00589, DE Phage integrase family, score 1.7e-69 218491003579 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 218491003580 Signal peptide predicted for ECA0771 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 21 and 22; signal peptide 218491003581 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 218491003582 dimerization domain [polypeptide binding]; other site 218491003583 dimer interface [polypeptide binding]; other site 218491003584 catalytic residues [active] 218491003585 PS00194 Thioredoxin family active site. 218491003586 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 218491003587 DHH family; Region: DHH; pfam01368 218491003588 DHHA1 domain; Region: DHHA1; pfam02272 218491003589 HMMPfam hit to PF01368, DE DHH family, score 2e-49 218491003590 HMMPfam hit to PF02272, DE DHHA1 domain, score 1.2e-13 218491003591 peptide chain release factor 2; Validated; Region: prfB; PRK00578 218491003592 This domain is found in peptide chain release factors; Region: PCRF; smart00937 218491003593 RF-1 domain; Region: RF-1; pfam00472 218491003594 HMMPfam hit to PF03462, DE PCRF domain, score 1.5e-37 218491003595 HMMPfam hit to PF00472, DE Peptidyl-tRNA hydrolase domain, score 1.8e-68 218491003596 PS00745 Prokaryotic-type class I peptide chain release factors signature. 218491003597 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 218491003598 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 218491003599 dimer interface [polypeptide binding]; other site 218491003600 putative anticodon binding site; other site 218491003601 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 218491003602 motif 1; other site 218491003603 active site 218491003604 motif 2; other site 218491003605 motif 3; other site 218491003606 HMMPfam hit to PF01336, DE OB-fold nucleic acid binding domain, score 5.9e-11 218491003607 HMMPfam hit to PF00152, DE tRNA synthetases class II (D, K and N), score 1e-197 218491003608 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491003609 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491003610 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491003611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491003612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491003613 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.9 218491003614 PS00041 Bacterial regulatory proteins, araC family signature. 218491003615 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.3e-07 218491003616 Signal peptide predicted for ECA0776 by SignalP 2.0 HMM (Signal peptide probabilty 0.765) with cleavage site probability 0.721 between residues 24 and 25; signal peptide 218491003617 LysE type translocator; Region: LysE; cl00565 218491003618 6 probable transmembrane helices predicted for ECA0776 by TMHMM2.0 at aa 5-27, 39-61, 71-93, 127-149, 159-181 and 194-213 218491003619 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 218491003620 Signal peptide predicted for ECA0778 by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.930 between residues 37 and 38; signal peptide 218491003621 Tetratricopeptide repeat; Region: TPR_16; pfam13432 218491003622 2 probable transmembrane helices predicted for ECA0778 by TMHMM2.0 at aa 4-26 and 196-218 218491003623 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003624 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 218491003625 Signal peptide predicted for ECA0780 by SignalP 2.0 HMM (Signal peptide probabilty 0.906) with cleavage site probability 0.485 between residues 29 and 30; signal peptide 218491003626 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 218491003627 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003628 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 218491003629 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218491003630 putative acyl-acceptor binding pocket; other site 218491003631 HMMPfam hit to PF03279, DE Bacterial lipid A biosynthesis acyltransferase, score 2.4e-123 218491003632 1 probable transmembrane helix predicted for ECA0781 by TMHMM2.0 at aa 28-50 218491003633 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 218491003634 HMMPfam hit to PF00860, DE Permease family, score 1.1e-91 218491003635 11 probable transmembrane helices predicted for ECA0783 by TMHMM2.0 at aa 96-118, 123-145, 152-174, 179-201, 208-230, 240-262, 269-291, 311-333, 406-428, 462-484 and 497-514 218491003636 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003637 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003638 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 218491003639 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 218491003640 HMMPfam hit to PF00999, DE Sodium/hydrogen exchanger family, score 3.3e-105 218491003641 11 probable transmembrane helices predicted for ECA0784 by TMHMM2.0 at aa 4-26, 86-108, 113-135, 159-181, 185-207, 219-236, 241-260, 273-295, 315-337, 361-383 and 398-420 218491003642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218491003643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491003644 active site 218491003645 phosphorylation site [posttranslational modification] 218491003646 intermolecular recognition site; other site 218491003647 dimerization interface [polypeptide binding]; other site 218491003648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491003649 DNA binding site [nucleotide binding] 218491003650 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.5e-26 218491003651 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 8.6e-21 218491003652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218491003653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218491003654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491003655 dimer interface [polypeptide binding]; other site 218491003656 phosphorylation site [posttranslational modification] 218491003657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491003658 ATP binding site [chemical binding]; other site 218491003659 Mg2+ binding site [ion binding]; other site 218491003660 G-X-G motif; other site 218491003661 2 probable transmembrane helices predicted for ECA0786 by TMHMM2.0 at aa 45-67 and 203-225 218491003662 HMMPfam hit to PF00672, DE HAMP domain, score 0.0043 218491003663 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 2.3e-05 218491003664 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 3.7e-26 218491003665 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 218491003666 5 probable transmembrane helices predicted for ECA0787 by TMHMM2.0 at aa 10-27, 34-56, 66-88, 108-130 and 160-182 218491003667 Signal peptide predicted for ECA0788 by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.315 between residues 29 and 30; signal peptide 218491003668 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 218491003669 Signal peptide predicted for ECA0789 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.928 between residues 44 and 45; signal peptide 218491003670 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 218491003671 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 218491003672 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218491003673 HMMPfam hit to PF00263, DE Bacterial type II and III secretion system protein, score 4.5e-63 218491003674 Type IV pili component [Cell motility and secretion]; Region: COG5461 218491003675 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 218491003676 1 probable transmembrane helix predicted for ECA0790 by TMHMM2.0 at aa 15-32 218491003677 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003678 AAA domain; Region: AAA_31; pfam13614 218491003679 Type II/IV secretion system protein; Region: T2SE; pfam00437 218491003680 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 218491003681 ATP binding site [chemical binding]; other site 218491003682 Walker A motif; other site 218491003683 hexamer interface [polypeptide binding]; other site 218491003684 Walker B motif; other site 218491003685 HMMPfam hit to PF00437, DE Type II/IV secretion system protein, score 5.3e-07 218491003686 PS00227 Tubulin subunits alpha, beta, and gamma signature. 218491003687 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003688 Signal peptide predicted for ECA0793 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.584 between residues 28 and 29; signal peptide 218491003689 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 218491003690 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218491003691 5 probable transmembrane helices predicted for ECA0793 by TMHMM2.0 at aa 5-27, 95-114, 118-140, 267-285 and 300-322 218491003692 Signal peptide predicted for ECA0794 by SignalP 2.0 HMM (Signal peptide probabilty 0.714) with cleavage site probability 0.705 between residues 23 and 24; signal peptide 218491003693 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 218491003694 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218491003695 4 probable transmembrane helices predicted for ECA0794 by TMHMM2.0 at aa 4-23, 107-129, 139-161 and 289-311 218491003696 Signal peptide predicted for ECA0795 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.602 between residues 32 and 33; signal peptide 218491003697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491003698 binding surface 218491003699 TPR motif; other site 218491003700 Tetratricopeptide repeat; Region: TPR_12; pfam13424 218491003701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491003702 binding surface 218491003703 TPR motif; other site 218491003704 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003705 HMMPfam hit to PF00515, DE TPR Domain, score 3.6 218491003706 HMMPfam hit to PF00515, DE TPR Domain, score 0.0027 218491003707 HMMPfam hit to PF00515, DE TPR Domain, score 12 218491003708 1 probable transmembrane helix predicted for ECA0796 by TMHMM2.0 at aa 29-51 218491003709 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 218491003710 1 probable transmembrane helix predicted for ECA0797 by TMHMM2.0 at aa 36-58 218491003711 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 218491003712 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 218491003713 1 probable transmembrane helix predicted for ECA0798 by TMHMM2.0 at aa 38-60 218491003714 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 218491003715 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 218491003716 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 218491003717 Putative Ig domain; Region: He_PIG; pfam05345 218491003718 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 218491003719 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 218491003720 Putative Ig domain; Region: He_PIG; pfam05345 218491003721 Outer membrane efflux protein; Region: OEP; pfam02321 218491003722 Outer membrane efflux protein; Region: OEP; pfam02321 218491003723 Signal peptide predicted for ECA0801 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.439 between residues 21 and 22; signal peptide 218491003724 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491003725 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491003726 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 218491003727 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491003728 1 probable transmembrane helix predicted for ECA0802 by TMHMM2.0 at aa 185-207 218491003729 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 218491003730 active site 218491003731 putative substrate binding region [chemical binding]; other site 218491003732 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491003733 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491003734 8 probable transmembrane helices predicted for ECA0803 by TMHMM2.0 at aa 140-162, 175-194, 209-228, 245-267, 277-296, 349-371, 375-397 and 418-435 218491003735 Signal peptide predicted for ECA0804 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.831 between residues 19 and 20; signal peptide 218491003736 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 218491003737 active site 218491003738 catalytic site [active] 218491003739 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 218491003740 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 218491003741 Ca binding site [ion binding]; other site 218491003742 substrate binding site [chemical binding]; other site 218491003743 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 218491003744 hypothetical protein; Provisional; Region: PRK09956 218491003745 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 218491003746 Signal peptide predicted for ECA0806 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 20 and 21; signal peptide 218491003747 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 218491003748 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 218491003749 Na binding site [ion binding]; other site 218491003750 14 probable transmembrane helices predicted for ECA0806 by TMHMM2.0 at aa 7-25, 35-57, 78-100, 105-127, 148-170, 185-207, 214-236, 266-288, 301-323, 364-386, 407-426, 431-453, 465-487 and 497-519 218491003751 PS00457 Sodium:solute symporter family signature 2. 218491003752 HMMPfam hit to PF00474, DE Sodium:solute symporter family, score 1e-188 218491003753 PS00456 Sodium:solute symporter family signature 1. 218491003754 Predicted membrane protein [Function unknown]; Region: COG3162 218491003755 2 probable transmembrane helices predicted for ECA0807 by TMHMM2.0 at aa 25-47 and 62-84 218491003756 Pseudogene. This CDS appears to have a frameshift mutation around codon 20. Similar to Escherichia coli acetyl-coenzyme A synthetase Acs or b4069 SWALL:ACSA_ECOLI (SWALL:P27550) (652 aa) fasta scores: E(): 0, 83.12% id in 652 aa, and to Yersinia pestis acetyl-coenzyme a synthetase Acs or ypo0253 SWALL:Q8ZJ71 (EMBL:AJ414141) (652 aa) fasta scores: E(): 0, 85.42% id in 652 aa;acetyl-coenzyme A synthetase (pseudogene) 218491003757 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 7.3e-134 218491003758 PS00455 AMP-binding domain signature. 218491003759 Signal peptide predicted for ECA0811 by SignalP 2.0 HMM (Signal peptide probabilty 0.873) with cleavage site probability 0.752 between residues 19 and 20; signal peptide 218491003760 Secretin and TonB N terminus short domain; Region: STN; smart00965 218491003761 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 218491003762 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491003763 N-terminal plug; other site 218491003764 ligand-binding site [chemical binding]; other site 218491003765 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 1.7e-27 218491003766 RNA polymerase sigma factor; Provisional; Region: PRK12528 218491003767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491003768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491003769 DNA binding residues [nucleotide binding] 218491003770 HMMPfam hit to PF00776, , score 0.0021 218491003771 Predicted helix-turn-helix motif with score 1390.000, SD 3.92 at aa 141-162, sequence LTYRQVAEQLAVSERMVKKYMA 218491003772 fec operon regulator FecR; Reviewed; Region: PRK09774 218491003773 FecR protein; Region: FecR; pfam04773 218491003774 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 218491003775 7 probable transmembrane helices predicted for ECA0815 by TMHMM2.0 at aa 15-40, 61-83, 148-170, 207-229, 233-250, 255-277 and 304-326 218491003776 6 probable transmembrane helices predicted for ECA0816 by TMHMM2.0 at aa 12-34, 49-66, 73-90, 100-122, 134-156 and 182-199 218491003777 Signal peptide predicted for ECA0817 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.581 between residues 46 and 47; signal peptide 218491003778 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218491003779 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 218491003780 12 probable transmembrane helices predicted for ECA0817 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 107-129, 150-169, 179-201, 241-263, 278-300, 307-326, 330-352, 386-405 and 415-437 218491003781 4 probable transmembrane helices predicted for ECA0818 by TMHMM2.0 at aa 29-51, 66-88, 95-116 and 131-148 218491003782 D-mannonate oxidoreductase; Provisional; Region: PRK15037 218491003783 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218491003784 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218491003785 HMMPfam hit to PF01232, DE Mannitol dehydrogenase, score 1.4e-207 218491003786 PS00974 Mannitol dehydrogenases signature. 218491003787 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 218491003788 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218491003789 homodimer interface [polypeptide binding]; other site 218491003790 substrate-cofactor binding pocket; other site 218491003791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491003792 catalytic residue [active] 218491003793 HMMPfam hit to PF01053, DE Cys/Met metabolism PLP-dependent enzyme, score 1.4e-195 218491003794 L,D-transpeptidase; Provisional; Region: PRK10260 218491003795 Signal peptide predicted for ECA0821 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 24 and 25; signal peptide 218491003796 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218491003797 HMMPfam hit to PF03734, DE ErfK/YbiS/YcfS/YnhG, score 4.1e-65 218491003798 Predicted amidohydrolase [General function prediction only]; Region: COG0388 218491003799 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 218491003800 putative active site [active] 218491003801 catalytic triad [active] 218491003802 putative dimer interface [polypeptide binding]; other site 218491003803 HMMPfam hit to PF00795, DE Carbon-nitrogen hydrolase, score 3.7e-41 218491003804 PS01227 Uncharacterized protein family UPF0012 signature. 218491003805 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 218491003806 4 probable transmembrane helices predicted for ECA0823 by TMHMM2.0 at aa 5-27, 42-64, 84-106 and 141-163 218491003807 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 218491003808 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 218491003809 dimer interface [polypeptide binding]; other site 218491003810 PYR/PP interface [polypeptide binding]; other site 218491003811 TPP binding site [chemical binding]; other site 218491003812 substrate binding site [chemical binding]; other site 218491003813 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 218491003814 Domain of unknown function; Region: EKR; smart00890 218491003815 4Fe-4S binding domain; Region: Fer4_6; pfam12837 218491003816 4Fe-4S binding domain; Region: Fer4; pfam00037 218491003817 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 218491003818 TPP-binding site [chemical binding]; other site 218491003819 dimer interface [polypeptide binding]; other site 218491003820 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00066 218491003821 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491003822 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00022 218491003823 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491003824 HMMPfam hit to PF01558, DE Pyruvate ferredoxin/flavodoxin oxidoreductase, score 2.1e-76 218491003825 HMMPfam hit to PF01855, DE Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 4.9e-117 218491003826 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218491003827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491003828 Coenzyme A binding pocket [chemical binding]; other site 218491003829 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.2e-19 218491003830 LysE type translocator; Region: LysE; cl00565 218491003831 5 probable transmembrane helices predicted for ECA0827 by TMHMM2.0 at aa 5-27, 42-64, 71-89, 146-168 and 188-207 218491003832 HMMPfam hit to PF01810, DE LysE type translocator, score 1.8e-13 218491003833 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 218491003834 Signal peptide predicted for ECA0828 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.770 between residues 22 and 23; signal peptide 218491003835 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491003836 substrate binding pocket [chemical binding]; other site 218491003837 membrane-bound complex binding site; other site 218491003838 hinge residues; other site 218491003839 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 3.5e-51 218491003840 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491003841 3 probable transmembrane helices predicted for ECA0829 by TMHMM2.0 at aa 18-40, 53-73 and 88-110 218491003842 Signal peptide predicted for ECA0830 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 23 and 24; signal peptide 218491003843 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218491003844 AAA domain; Region: AAA_22; pfam13401 218491003845 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003846 integrase; Provisional; Region: PRK09692 218491003847 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491003848 active site 218491003849 Int/Topo IB signature motif; other site 218491003850 HMMPfam hit to PF00589, DE Phage integrase family, score 8.2e-32 218491003851 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 218491003852 SmpB-tmRNA interface; other site 218491003853 HMMPfam hit to PF01668, DE SmpB protein, score 4.3e-42 218491003854 PS01317 Protein smpB signature. 218491003855 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 218491003856 putative coenzyme Q binding site [chemical binding]; other site 218491003857 HMMPfam hit to PF03654, DE Aromatic-Rich Protein Family, score 7.4e-92 218491003858 hypothetical protein; Validated; Region: PRK01777 218491003859 HMMPfam hit to PF03658, DE Uncharacterised protein family (UPF0125), score 3.6e-49 218491003860 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 218491003861 Signal peptide predicted for ECA0839 by SignalP 2.0 HMM (Signal peptide probabilty 0.896) with cleavage site probability 0.407 between residues 22 and 23; signal peptide 218491003862 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 218491003863 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491003864 recombination and repair protein; Provisional; Region: PRK10869 218491003865 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 218491003866 Walker A/P-loop; other site 218491003867 ATP binding site [chemical binding]; other site 218491003868 Q-loop/lid; other site 218491003869 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 218491003870 ABC transporter signature motif; other site 218491003871 Walker B; other site 218491003872 D-loop; other site 218491003873 H-loop/switch region; other site 218491003874 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003875 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 218491003876 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 218491003877 HMMPfam hit to PF01513, DE ATP-NAD kinase, score 1.2e-111 218491003878 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 218491003879 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 218491003880 dimer interface [polypeptide binding]; other site 218491003881 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 218491003882 HMMPfam hit to PF01025, DE GrpE, score 4e-64 218491003883 PS01071 grpE protein signature. 218491003884 manganese transport protein MntH; Reviewed; Region: PRK00701 218491003885 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 218491003886 10 probable transmembrane helices predicted for ECA0843 by TMHMM2.0 at aa 15-37, 44-66, 121-143, 150-172, 194-216, 237-259, 286-308, 315-337, 347-369 and 390-409 218491003887 HMMPfam hit to PF01566, DE Natural resistance-associated macrophage protein, score 1.3e-185 218491003888 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 218491003889 active site 1 [active] 218491003890 dimer interface [polypeptide binding]; other site 218491003891 hexamer interface [polypeptide binding]; other site 218491003892 active site 2 [active] 218491003893 HMMPfam hit to PF01361, DE Tautomerase enzyme, score 3.1e-17 218491003894 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 218491003895 11 probable transmembrane helices predicted for ECA0845 by TMHMM2.0 at aa 22-44, 56-78, 83-105, 112-134, 144-163, 189-211, 221-240, 245-267, 272-294, 307-329 and 334-356 218491003896 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 218491003897 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 218491003898 dimer interface [polypeptide binding]; other site 218491003899 active site 218491003900 metal binding site [ion binding]; metal-binding site 218491003901 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 5.4e-76 218491003902 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 218491003903 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218491003904 dimer interface [polypeptide binding]; other site 218491003905 ADP-ribose binding site [chemical binding]; other site 218491003906 active site 218491003907 nudix motif; other site 218491003908 metal binding site [ion binding]; metal-binding site 218491003909 HMMPfam hit to PF00293, DE NUDIX domain, score 4.2e-16 218491003910 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218491003912 Signal peptide predicted for ECA0848 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 26 and 27; signal peptide 218491003913 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 8.1e-38 218491003914 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003915 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218491003916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491003917 dimer interface [polypeptide binding]; other site 218491003918 conserved gate region; other site 218491003919 putative PBP binding loops; other site 218491003920 ABC-ATPase subunit interface; other site 218491003921 6 probable transmembrane helices predicted for ECA0849 by TMHMM2.0 at aa 13-35, 71-93, 106-125, 161-183, 204-226 and 265-287 218491003922 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 7.9e-18 218491003923 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491003924 Signal peptide predicted for ECA0850 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.429 between residues 38 and 39; signal peptide 218491003925 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218491003926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491003927 dimer interface [polypeptide binding]; other site 218491003928 conserved gate region; other site 218491003929 putative PBP binding loops; other site 218491003930 ABC-ATPase subunit interface; other site 218491003931 6 probable transmembrane helices predicted for ECA0850 by TMHMM2.0 at aa 9-31, 75-97, 104-126, 136-153, 191-213 and 236-255 218491003932 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.00043 218491003933 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218491003934 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218491003935 Walker A/P-loop; other site 218491003936 ATP binding site [chemical binding]; other site 218491003937 Q-loop/lid; other site 218491003938 ABC transporter signature motif; other site 218491003939 Walker B; other site 218491003940 D-loop; other site 218491003941 H-loop/switch region; other site 218491003942 TOBE domain; Region: TOBE_2; pfam08402 218491003943 HMMPfam hit to PF00005, DE ABC transporter, score 7.8e-66 218491003944 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003945 PS00211 ABC transporters family signature. 218491003946 Signal peptide predicted for ECA0852 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.629 between residues 28 and 29; signal peptide 218491003947 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 218491003948 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 218491003949 putative sugar binding sites [chemical binding]; other site 218491003950 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 218491003951 Q-X-W motif; other site 218491003952 HMMPfam hit to PF00652, DE QXW lectin repeat, score 0.062 218491003953 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003954 HMMPfam hit to PF00652, DE QXW lectin repeat, score 0.98 218491003955 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00652, DE QXW lectin repeat, score 0.00043 218491003956 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 218491003957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491003958 DNA binding site [nucleotide binding] 218491003959 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 218491003960 putative dimerization interface [polypeptide binding]; other site 218491003961 putative ligand binding site [chemical binding]; other site 218491003962 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 5.8e-07 218491003963 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 5.8e-09 218491003964 Predicted helix-turn-helix motif with score 2142.000, SD 6.48 at aa 2-23, sequence TTIRDIAQKAGVAASTVSRVLN 218491003965 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491003966 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491003967 Walker A/P-loop; other site 218491003968 ATP binding site [chemical binding]; other site 218491003969 Q-loop/lid; other site 218491003970 ABC transporter signature motif; other site 218491003971 Walker B; other site 218491003972 D-loop; other site 218491003973 H-loop/switch region; other site 218491003974 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-64 218491003975 PS00211 ABC transporters family signature. 218491003976 PS00017 ATP/GTP-binding site motif A (P-loop). 218491003977 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491003978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491003979 dimer interface [polypeptide binding]; other site 218491003980 conserved gate region; other site 218491003981 putative PBP binding loops; other site 218491003982 ABC-ATPase subunit interface; other site 218491003983 5 probable transmembrane helices predicted for ECA0855 by TMHMM2.0 at aa 21-38, 58-80, 93-115, 135-157 and 249-271 218491003984 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.8e-14 218491003985 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491003986 Signal peptide predicted for ECA0856 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.904 between residues 21 and 22; signal peptide 218491003987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491003988 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491003989 substrate binding pocket [chemical binding]; other site 218491003990 membrane-bound complex binding site; other site 218491003991 hinge residues; other site 218491003992 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 1.9e-45 218491003993 transcriptional antiterminator BglG; Provisional; Region: PRK09772 218491003994 CAT RNA binding domain; Region: CAT_RBD; smart01061 218491003995 PRD domain; Region: PRD; pfam00874 218491003996 PRD domain; Region: PRD; pfam00874 218491003997 HMMPfam hit to PF00874, DE PRD domain, score 2.1e-07 218491003998 HMMPfam hit to PF00874, DE PRD domain, score 2.2e-31 218491003999 HMMPfam hit to PF03123, DE CAT RNA binding domain, score 1e-13 218491004000 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 218491004001 beta-galactosidase; Region: BGL; TIGR03356 218491004002 HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 1.1e-173 218491004003 PS00572 Glycosyl hydrolases family 1 active site. 218491004004 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004005 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491004006 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 218491004007 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491004008 active site turn [active] 218491004009 phosphorylation site [posttranslational modification] 218491004010 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491004011 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 218491004012 HPr interaction site; other site 218491004013 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218491004014 active site 218491004015 phosphorylation site [posttranslational modification] 218491004016 HMMPfam hit to PF00358, DE phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 3.3e-51 218491004017 PS00371 PTS EIIA domains phosphorylation site signature 1. 218491004018 9 probable transmembrane helices predicted for ECA0860 by TMHMM2.0 at aa 103-125, 161-183, 190-212, 217-234, 254-276, 291-313, 360-382, 388-410 and 431-453 218491004019 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 2.8e-18 218491004020 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 1.5e-08 218491004021 transketolase; Reviewed; Region: PRK12753 218491004022 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218491004023 TPP-binding site [chemical binding]; other site 218491004024 dimer interface [polypeptide binding]; other site 218491004025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218491004026 PYR/PP interface [polypeptide binding]; other site 218491004027 dimer interface [polypeptide binding]; other site 218491004028 TPP binding site [chemical binding]; other site 218491004029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218491004030 HMMPfam hit to PF02780, DE Transketolase, C-terminal domain, score 4.5e-13 218491004031 HMMPfam hit to PF02779, DE Transketolase, pyridine binding domain, score 8.2e-66 218491004032 PS00802 Transketolase signature 2. 218491004033 HMMPfam hit to PF00456, DE Transketolase, thiamine diphosphate binding domain, score 1.2e-238 218491004034 PS00801 Transketolase signature 1. 218491004035 transaldolase-like protein; Provisional; Region: PTZ00411 218491004036 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 218491004037 active site 218491004038 dimer interface [polypeptide binding]; other site 218491004039 catalytic residue [active] 218491004040 HMMPfam hit to PF00923, DE Transaldolase, score 4.2e-149 218491004041 PS00958 Transaldolase active site. 218491004042 PS01054 Transaldolase signature 1. 218491004043 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 218491004044 HMMPfam hit to PF02502, DE Ribose/Galactose Isomerase, score 2.4e-43 218491004045 PS00213 Lipocalin signature. 218491004046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491004047 D-galactonate transporter; Region: 2A0114; TIGR00893 218491004048 putative substrate translocation pore; other site 218491004049 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0098 218491004050 12 probable transmembrane helices predicted for ECA0865 by TMHMM2.0 at aa 37-59, 69-91, 104-123, 128-150, 163-185, 200-219, 264-286, 306-323, 335-354, 358-380, 385-407 and 422-444 218491004051 dihydroxyacetone kinase; Provisional; Region: PRK14479 218491004052 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 218491004053 DAK2 domain; Region: Dak2; pfam02734 218491004054 HMMPfam hit to PF02733, DE Dak1 domain, score 2.3e-129 218491004055 HMMPfam hit to PF02734, DE DAK2 domain, score 4.1e-47 218491004056 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 218491004057 substrate binding site [chemical binding]; other site 218491004058 dimer interface [polypeptide binding]; other site 218491004059 catalytic triad [active] 218491004060 HMMPfam hit to PF00121, DE Triosephosphate isomerase, score 8.6e-24 218491004061 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 218491004062 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 218491004063 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 218491004064 Homeodomain-like domain; Region: HTH_23; pfam13384 218491004065 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 218491004066 Predicted helix-turn-helix motif with score 1986.000, SD 5.95 at aa 25-46, sequence ITQEEIAKKFGISRIKVGRLLK 218491004067 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 218491004068 Malic enzyme, N-terminal domain; Region: malic; pfam00390 218491004069 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 218491004070 putative NAD(P) binding site [chemical binding]; other site 218491004071 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 218491004072 HMMPfam hit to PF00390, DE Malic enzyme, N-terminal domain, score 3.6e-78 218491004073 HMMPfam hit to PF03949, DE Malic enzyme, NAD binding domain, score 5e-131 218491004074 HMMPfam hit to PF01515, DE Phosphate acetyl/butaryl transferase, score 2.9e-115 218491004075 tryptophan permease; Provisional; Region: PRK10483 218491004076 aromatic amino acid transport protein; Region: araaP; TIGR00837 218491004077 HMMPfam hit to PF03222, DE Tryptophan/tyrosine permease family, score 1.4e-211 218491004078 11 probable transmembrane helices predicted for ECA0872 by TMHMM2.0 at aa 23-45, 55-77, 98-120, 135-157, 164-183, 203-225, 238-257, 294-316, 337-354, 358-380 and 393-415 218491004079 PS00594 Aromatic amino acids permeases signature. 218491004080 hypothetical protein; Validated; Region: PRK00124 218491004081 HMMPfam hit to PF02639, DE Uncharacterized BCR, YaiI/YqxD family COG1671, score 3.5e-77 218491004082 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 218491004083 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 218491004084 HMMPfam hit to PF01218, DE Coproporphyrinogen III oxidase, score 3.3e-204 218491004085 PS01021 Coproporphyrinogen III oxidase signature. 218491004086 putative acetyltransferase; Provisional; Region: PRK03624 218491004087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491004088 Coenzyme A binding pocket [chemical binding]; other site 218491004089 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 3e-21 218491004090 Signal peptide predicted for ECA0876 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.957 between residues 24 and 25; signal peptide 218491004091 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491004092 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491004093 N-terminal plug; other site 218491004094 ligand-binding site [chemical binding]; other site 218491004095 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491004096 HMMPfam hit to PF00593, DE TonB dependent receptor, score 2.4e-09 218491004097 Signal peptide predicted for ECA0877 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.500 between residues 21 and 22; signal peptide 218491004098 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 218491004099 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004100 HMMPfam hit to PF03544, DE Gram-negative bacterial tonB protein, score 6.4e-14 218491004101 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 218491004102 Signal peptide predicted for ECA0879 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.756 between residues 25 and 26; signal peptide 218491004103 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 218491004104 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218491004105 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218491004106 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 218491004107 HMMPfam hit to PF00675, DE Insulinase (Peptidase family M16), score 6.3e-12 218491004108 PS00143 Insulinase family, zinc-binding region signature. 218491004109 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 218491004110 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 218491004111 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 218491004112 5 probable transmembrane helices predicted for ECA0880 by TMHMM2.0 at aa 21-43, 58-80, 138-160, 180-199 and 267-289 218491004113 HMMPfam hit to PF00005, DE ABC transporter, score 3e-23 218491004114 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004115 PS00211 ABC transporters family signature. 218491004116 Signal peptide predicted for ECA0881 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.409 between residues 43 and 44; signal peptide 218491004117 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 218491004118 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 218491004119 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 218491004120 Signal peptide predicted for ECA0883 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.806 between residues 28 and 29; signal peptide 218491004121 thiosulfate transporter subunit; Provisional; Region: PRK10852 218491004122 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218491004123 HMMPfam hit to PF01100, , score 6.1e-202 218491004124 PS00757 Prokaryotic sulfate-binding proteins signature 2. 218491004125 Signal peptide predicted for ECA0884 by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.807 between residues 43 and 44; signal peptide 218491004126 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 218491004127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491004128 dimer interface [polypeptide binding]; other site 218491004129 conserved gate region; other site 218491004130 putative PBP binding loops; other site 218491004131 ABC-ATPase subunit interface; other site 218491004132 7 probable transmembrane helices predicted for ECA0884 by TMHMM2.0 at aa 20-42, 69-91, 111-133, 145-167, 195-212, 219-241 and 251-273 218491004133 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.7e-18 218491004134 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491004135 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 218491004136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491004137 dimer interface [polypeptide binding]; other site 218491004138 conserved gate region; other site 218491004139 putative PBP binding loops; other site 218491004140 ABC-ATPase subunit interface; other site 218491004141 6 probable transmembrane helices predicted for ECA0885 by TMHMM2.0 at aa 27-49, 73-95, 108-130, 145-167, 206-228 and 251-273 218491004142 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.4e-06 218491004143 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491004144 cysteine synthase B; Region: cysM; TIGR01138 218491004145 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 218491004146 dimer interface [polypeptide binding]; other site 218491004147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491004148 catalytic residue [active] 218491004149 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 3.4e-97 218491004150 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 218491004151 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 218491004152 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218491004153 Walker A/P-loop; other site 218491004154 ATP binding site [chemical binding]; other site 218491004155 Q-loop/lid; other site 218491004156 ABC transporter signature motif; other site 218491004157 Walker B; other site 218491004158 D-loop; other site 218491004159 H-loop/switch region; other site 218491004160 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218491004161 FtsX-like permease family; Region: FtsX; pfam02687 218491004162 HMMPfam hit to PF02687, DE Predicted permease, score 1.8e-40 218491004163 4 probable transmembrane helices predicted for ECA0887 by TMHMM2.0 at aa 275-294, 523-545, 579-601 and 616-635 218491004164 HMMPfam hit to PF00005, DE ABC transporter, score 4.7e-55 218491004165 PS00211 ABC transporters family signature. 218491004166 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004167 Signal peptide predicted for ECA0888 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.258 between residues 36 and 37; signal peptide 218491004168 macrolide transporter subunit MacA; Provisional; Region: PRK11578 218491004169 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491004170 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491004171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218491004172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491004173 active site 218491004174 phosphorylation site [posttranslational modification] 218491004175 intermolecular recognition site; other site 218491004176 dimerization interface [polypeptide binding]; other site 218491004177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491004178 DNA binding site [nucleotide binding] 218491004179 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.1e-29 218491004180 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 7.3e-22 218491004181 Signal peptide predicted for ECA0890 by SignalP 2.0 HMM (Signal peptide probabilty 0.875) with cleavage site probability 0.362 between residues 23 and 24 218491004182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218491004183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491004184 dimerization interface [polypeptide binding]; other site 218491004185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491004186 dimer interface [polypeptide binding]; other site 218491004187 phosphorylation site [posttranslational modification] 218491004188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491004189 ATP binding site [chemical binding]; other site 218491004190 Mg2+ binding site [ion binding]; other site 218491004191 G-X-G motif; other site 218491004192 2 probable transmembrane helices predicted for ECA0890 by TMHMM2.0 at aa 7-29 and 161-183 218491004193 HMMPfam hit to PF00672, DE HAMP domain, score 4.3e-11 218491004194 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 7.7e-12 218491004195 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.1e-26 218491004196 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218491004197 HPr interaction site; other site 218491004198 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218491004199 active site 218491004200 phosphorylation site [posttranslational modification] 218491004201 HMMPfam hit to PF00358, DE phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 2e-65 218491004202 PS00371 PTS EIIA domains phosphorylation site signature 1. 218491004203 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 218491004204 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218491004205 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218491004206 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218491004207 HMMPfam hit to PF02896, DE PEP-utilising enzyme, TIM barrel domain, score 1.9e-185 218491004208 PS00742 PEP-utilizing enzymes signature 2. 218491004209 HMMPfam hit to PF00391, DE PEP-utilising enzyme, mobile domain, score 9.7e-34 218491004210 PS00370 PEP-utilizing enzymes phosphorylation site signature. 218491004211 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218491004212 dimerization domain swap beta strand [polypeptide binding]; other site 218491004213 regulatory protein interface [polypeptide binding]; other site 218491004214 active site 218491004215 regulatory phosphorylation site [posttranslational modification]; other site 218491004216 HMMPfam hit to PF00381, DE PTS HPr component phosphorylation site, score 3.3e-46 218491004217 PS00589 PTS HPR component serine phosphorylation site signature. 218491004218 PS00369 PTS HPR component histidine phosphorylation site signature. 218491004219 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 218491004220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 218491004221 dimer interface [polypeptide binding]; other site 218491004222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491004223 catalytic residue [active] 218491004224 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 5.3e-128 218491004225 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 218491004226 putative sulfate transport protein CysZ; Validated; Region: PRK04949 218491004227 4 probable transmembrane helices predicted for ECA0895 by TMHMM2.0 at aa 7-29, 49-71, 130-152 and 194-216 218491004228 cell division protein ZipA; Provisional; Region: PRK03427 218491004229 Signal peptide predicted for ECA0896 by SignalP 2.0 HMM (Signal peptide probabilty 0.851) with cleavage site probability 0.786 between residues 20 and 21; signal peptide 218491004230 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 218491004231 FtsZ protein binding site [polypeptide binding]; other site 218491004232 1 probable transmembrane helix predicted for ECA0896 by TMHMM2.0 at aa 3-22 218491004233 putative transporter; Provisional; Region: PRK11021 218491004234 HMMPfam hit to PF00324, DE Amino acid permease, score 0.0092 218491004235 11 probable transmembrane helices predicted for ECA0897 by TMHMM2.0 at aa 12-34, 44-66, 92-114, 118-140, 147-169, 189-211, 223-245, 265-287, 317-339, 344-366 and 373-407 218491004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 218491004237 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 218491004238 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 218491004239 HMMPfam hit to PF00926, DE 3,4-dihydroxy-2-butanone 4-phosphate synthase, score 9.5e-126 218491004240 tellurite resistance protein TehB; Provisional; Region: PRK12335 218491004241 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 218491004242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491004243 S-adenosylmethionine binding site [chemical binding]; other site 218491004244 HMMPfam hit to PF03848, DE Tellurite resistance protein TehB, score 1.6e-141 218491004245 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 218491004246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491004247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491004248 hydroxyglutarate oxidase; Provisional; Region: PRK11728 218491004249 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 1.3e-59 218491004250 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 218491004251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218491004252 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 218491004253 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 218491004254 iron binding site [ion binding]; other site 218491004255 HMMPfam hit to PF00301, DE Rubredoxin, score 2.7e-20 218491004256 HMMPfam hit to PF00258, DE Flavodoxin, score 1.6e-22 218491004257 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 6.2e-23 218491004258 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 218491004259 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218491004260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491004261 Walker A motif; other site 218491004262 ATP binding site [chemical binding]; other site 218491004263 Walker B motif; other site 218491004264 arginine finger; other site 218491004265 HMMPfam hit to PF01590, DE GAF domain, score 2.7e-13 218491004266 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 1.2e-134 218491004267 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491004268 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491004269 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491004270 fumarate hydratase; Provisional; Region: PRK15389 218491004271 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 218491004272 Fumarase C-terminus; Region: Fumerase_C; pfam05683 218491004273 HMMPfam hit to PF00206, DE Lyase, score 8.4e-82 218491004274 PS00163 Fumarate lyases signature. 218491004275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491004276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491004277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491004278 dimerization interface [polypeptide binding]; other site 218491004279 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.4e-24 218491004280 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.6e-17 218491004281 Predicted helix-turn-helix motif with score 1881.000, SD 5.59 at aa 18-39, sequence GSFSAAARRLHKSQSTISAAIA 218491004282 Predicted membrane protein [Function unknown]; Region: COG4125 218491004283 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 218491004284 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 218491004285 4 probable transmembrane helices predicted for ECA0906 by TMHMM2.0 at aa 13-35, 45-64, 84-106 and 110-132 218491004286 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218491004287 endonuclease III; Region: ENDO3c; smart00478 218491004288 minor groove reading motif; other site 218491004289 helix-hairpin-helix signature motif; other site 218491004290 substrate binding pocket [chemical binding]; other site 218491004291 active site 218491004292 HMMPfam hit to PF00730, DE HhH-GPD superfamily base excision DNA repair protein, score 0.061 218491004293 PS00516 Alkylbase DNA glycosidases alkA family signature. 218491004294 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 218491004295 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 218491004296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491004297 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 218491004298 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218491004299 DNA binding site [nucleotide binding] 218491004300 active site 218491004301 HMMPfam hit to PF02805, DE Metal binding domain of Ada, score 2.7e-31 218491004302 PS00041 Bacterial regulatory proteins, araC family signature. 218491004303 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 2.3e-09 218491004304 Predicted helix-turn-helix motif with score 1234.000, SD 3.39 at aa 107-128, sequence PTLAVLAQAVGMSAFHFHRVFK 218491004305 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 22 218491004306 HMMPfam hit to PF02870, DE 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain, score 0.00058 218491004307 HMMPfam hit to PF01035, DE 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 2.8e-44 218491004308 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 218491004309 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 218491004310 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03171, DE 2OG-Fe(II) oxygenase superfamily, score 0.003 218491004311 Signal peptide predicted for ECA0910 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.943 between residues 24 and 25; signal peptide 218491004312 hypothetical protein; Validated; Region: PRK07121 218491004313 Predicted oxidoreductase [General function prediction only]; Region: COG3573 218491004314 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 218491004315 HMMPfam hit to PF00890, DE FAD binding domain, score 2.3e-05 218491004316 Signal peptide predicted for ECA0911 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.909 between residues 21 and 22; signal peptide 218491004317 FMN-binding domain; Region: FMN_bind; pfam04205 218491004318 putative transporter; Provisional; Region: PRK10504 218491004319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491004320 putative substrate translocation pore; other site 218491004321 14 probable transmembrane helices predicted for ECA0912 by TMHMM2.0 at aa 5-27, 42-64, 76-98, 102-120, 132-154, 159-181, 193-212, 217-239, 260-282, 297-314, 321-343, 353-375, 388-410 and 425-447 218491004322 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 218491004323 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 218491004324 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03916, DE Polysulphide reductase, NrfD, score 8.9e-92 218491004325 8 probable transmembrane helices predicted for ECA0913 by TMHMM2.0 at aa 15-37, 49-71, 91-113, 146-168, 183-205, 225-244, 259-281 and 293-315 218491004326 Signal peptide predicted for ECA0914 by SignalP 2.0 HMM (Signal peptide probabilty 0.923) with cleavage site probability 0.918 between residues 28 and 29; signal peptide 218491004327 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 218491004328 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491004329 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.15 218491004330 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00026 218491004331 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491004332 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.064 218491004333 Signal peptide predicted for ECA0915 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.608 between residues 24 and 25; signal peptide 218491004334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 218491004335 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 218491004336 substrate binding pocket [chemical binding]; other site 218491004337 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218491004338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491004339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491004340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491004341 dimerization interface [polypeptide binding]; other site 218491004342 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 4.7e-13 218491004343 Predicted helix-turn-helix motif with score 1663.000, SD 4.85 at aa 17-38, sequence GSFTKAAKALNISQAFLSQEIA 218491004344 PS00044 Bacterial regulatory proteins, lysR family signature. 218491004345 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6e-26 218491004346 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 218491004347 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 218491004348 putative active site pocket [active] 218491004349 putative metal binding site [ion binding]; other site 218491004350 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 2.5e-53 218491004351 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 218491004352 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 3.1e-154 218491004353 putative oxidoreductase; Provisional; Region: PRK10083 218491004354 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 218491004355 putative NAD(P) binding site [chemical binding]; other site 218491004356 catalytic Zn binding site [ion binding]; other site 218491004357 structural Zn binding site [ion binding]; other site 218491004358 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 1.1e-79 218491004359 PS00059 Zinc-containing alcohol dehydrogenases signature. 218491004360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491004361 metabolite-proton symporter; Region: 2A0106; TIGR00883 218491004362 putative substrate translocation pore; other site 218491004363 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 1.4e-18 218491004364 12 probable transmembrane helices predicted for ECA0919 by TMHMM2.0 at aa 25-47, 62-84, 96-118, 122-141, 161-183, 193-215, 264-286, 296-318, 325-347, 357-379, 392-414 and 419-441 218491004365 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 218491004366 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218491004367 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218491004368 HMMPfam hit to PF01232, DE Mannitol dehydrogenase, score 1.8e-207 218491004369 PS00974 Mannitol dehydrogenases signature. 218491004370 Transcriptional regulators [Transcription]; Region: GntR; COG1802 218491004371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491004372 DNA-binding site [nucleotide binding]; DNA binding site 218491004373 FCD domain; Region: FCD; pfam07729 218491004374 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 6.2e-13 218491004375 PS00043 Bacterial regulatory proteins, gntR family signature. 218491004376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491004377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491004378 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 218491004379 putative effector binding pocket; other site 218491004380 putative dimerization interface [polypeptide binding]; other site 218491004381 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 4.5e-33 218491004382 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 9.8e-16 218491004383 PS00044 Bacterial regulatory proteins, lysR family signature. 218491004384 Predicted helix-turn-helix motif with score 1529.000, SD 4.39 at aa 9-30, sequence GSFTAAAEKMNLTSSAVSKGIA 218491004385 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 218491004386 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 218491004387 NADP binding site [chemical binding]; other site 218491004388 PS00430 TonB-dependent receptor proteins signature 1. 218491004389 Signal peptide predicted for ECA0924 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 20 and 21; signal peptide 218491004390 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 218491004391 Signal peptide predicted for ECA0925 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.988 between residues 36 and 37; signal peptide 218491004392 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 218491004393 PLD-like domain; Region: PLDc_2; pfam13091 218491004394 putative active site [active] 218491004395 putative catalytic site [active] 218491004396 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 218491004397 PLD-like domain; Region: PLDc_2; pfam13091 218491004398 putative active site [active] 218491004399 putative catalytic site [active] 218491004400 HMMPfam hit to PF00614, DE Phospholipase D. Active site motif, score 0.23 218491004401 HMMPfam hit to PF00614, DE Phospholipase D. Active site motif, score 0.00084 218491004402 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 218491004403 PS00881 Protein splicing signature. 218491004404 HMMPfam hit to PF01618, DE MotA/TolQ/ExbB proton channel family, score 3.4e-16 218491004405 3 probable transmembrane helices predicted for ECA0926 by TMHMM2.0 at aa 10-32, 106-128 and 148-170 218491004406 PS00079 Multicopper oxidases signature 1. 218491004407 Signal peptide predicted for ECA0927 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25; signal peptide 218491004408 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491004409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491004410 N-terminal plug; other site 218491004411 ligand-binding site [chemical binding]; other site 218491004412 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 2.4e-16 218491004413 Signal peptide predicted for ECA0928 by SignalP 2.0 HMM (Signal peptide probabilty 0.727) with cleavage site probability 0.353 between residues 28 and 29; signal peptide 218491004414 Gram-negative bacterial tonB protein; Region: TonB; cl10048 218491004415 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218491004416 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 218491004417 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02472, DE Biopolymer transport protein ExbD/TolR, score 2e-28 218491004418 1 probable transmembrane helix predicted for ECA0929 by TMHMM2.0 at aa 16-38 218491004419 drug efflux system protein MdtG; Provisional; Region: PRK09874 218491004420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491004421 putative substrate translocation pore; other site 218491004422 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00037 218491004423 9 probable transmembrane helices predicted for ECA0930 by TMHMM2.0 at aa 26-48, 61-83, 113-135, 142-164, 184-206, 227-246, 256-278, 285-307 and 347-369 218491004424 Signal peptide predicted for ECA0931 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.954 between residues 28 and 29; signal peptide 218491004425 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 218491004426 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491004427 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 218491004428 Na binding site [ion binding]; other site 218491004429 12 probable transmembrane helices predicted for ECA0932 by TMHMM2.0 at aa 20-42, 52-74, 94-116, 131-153, 160-182, 192-214, 227-249, 259-281, 305-327, 333-355, 376-398 and 402-421 218491004430 HMMPfam hit to PF02133, DE Permease for cytosine/purines, uracil, thiamine, allantoin, score 4.4e-06 218491004431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218491004432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491004433 DNA binding residues [nucleotide binding] 218491004434 dimerization interface [polypeptide binding]; other site 218491004435 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 1.5e-08 218491004436 Predicted helix-turn-helix motif with score 1711.000, SD 5.01 at aa 169-190, sequence FSNKEIARKMNVSPKTIENRIY 218491004437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491004438 Coenzyme A binding pocket [chemical binding]; other site 218491004439 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.5e-13 218491004440 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 218491004441 Signal peptide predicted for ECA0935 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.956 between residues 44 and 45; signal peptide 218491004442 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491004443 N-terminal plug; other site 218491004444 ligand-binding site [chemical binding]; other site 218491004445 PS00430 TonB-dependent receptor proteins signature 1. 218491004446 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004447 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 2.7e-24 218491004448 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491004449 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 218491004450 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 218491004451 active site 218491004452 tetramer interface [polypeptide binding]; other site 218491004453 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 2.2e-05 218491004454 PS00200 Rieske iron-sulfur protein signature 2. 218491004455 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 218491004456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491004457 putative substrate translocation pore; other site 218491004458 12 probable transmembrane helices predicted for ECA0937 by TMHMM2.0 at aa 21-38, 58-80, 93-113, 118-140, 153-175, 188-210, 256-278, 288-310, 323-340, 344-366, 373-395 and 410-429 218491004459 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 218491004460 4 probable transmembrane helices predicted for ECA0938 by TMHMM2.0 at aa 30-52, 67-89, 102-124 and 134-153 218491004461 Signal peptide predicted for ECA0939 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.995 between residues 34 and 35; signal peptide 218491004462 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 218491004463 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00419, DE Fimbrial protein, score 8e-14 218491004464 Signal peptide predicted for ECA0940 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.731 between residues 29 and 30; signal peptide 218491004465 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 218491004466 Signal peptide predicted for ECA0941 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.793 between residues 25 and 26; signal peptide 218491004467 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218491004468 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 218491004469 HMMPfam hit to PF02753, DE Gram-negative pili assembly chaperone, C-terminal domain, score 5.6e-07 218491004470 HMMPfam hit to PF00345, DE Gram-negative pili assembly chaperone, N-terminal domain, score 1.9e-42 218491004471 PS00635 Gram-negative pili assembly chaperone signature. 218491004472 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 218491004473 PapC N-terminal domain; Region: PapC_N; pfam13954 218491004474 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218491004475 PapC C-terminal domain; Region: PapC_C; pfam13953 218491004476 HMMPfam hit to PF00577, DE Fimbrial Usher protein, score 2e-277 218491004477 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 218491004478 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 218491004479 Signal peptide predicted for ECA0943 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 22 and 23; signal peptide 218491004480 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00419, DE Fimbrial protein, score 3.5e-33 218491004481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 218491004482 1 probable transmembrane helix predicted for ECA0944 by TMHMM2.0 at aa 171-193 218491004483 Signal peptide predicted for ECA0945 by SignalP 2.0 HMM (Signal peptide probabilty 0.942) with cleavage site probability 0.637 between residues 24 and 25; signal peptide 218491004484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491004485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491004486 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 218491004487 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 4.8e-13 218491004488 Predicted helix-turn-helix motif with score 2218.000, SD 6.74 at aa 50-71, sequence VTTRELAEHVGISRSHLYHYFP 218491004489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218491004490 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 218491004491 5 probable transmembrane helices predicted for ECA0947 by TMHMM2.0 at aa 31-53, 63-82, 130-152, 157-174 and 227-249 218491004492 Signal peptide predicted for ECA0948 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 21 and 22; signal peptide 218491004493 Signal peptide predicted for ECA0949 by SignalP 2.0 HMM (Signal peptide probabilty 0.918) with cleavage site probability 0.862 between residues 20 and 21; signal peptide 218491004494 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 218491004495 hypothetical protein; Provisional; Region: PRK10621 218491004496 6 probable transmembrane helices predicted for ECA0949 by TMHMM2.0 at aa 5-27, 74-93, 100-118, 144-166, 193-215 and 230-249 218491004497 HMMPfam hit to PF01925, DE Domain of unknown function DUF81, score 8.5e-06 218491004498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491004499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491004500 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 1.2e-12 218491004501 Predicted helix-turn-helix motif with score 1678.000, SD 4.90 at aa 35-56, sequence LTLGHLAEQAGVTKPVVYDHFT 218491004502 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 218491004503 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218491004504 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02525, DE Flavodoxin-like fold, score 1.8e-38 218491004505 1 probable transmembrane helix predicted for ECA0953 by TMHMM2.0 at aa 10-27 218491004506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491004507 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218491004508 Coenzyme A binding pocket [chemical binding]; other site 218491004509 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 6.5e-11 218491004510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491004511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491004512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491004513 dimerization interface [polypeptide binding]; other site 218491004514 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5e-47 218491004515 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.3e-24 218491004516 PS00044 Bacterial regulatory proteins, lysR family signature. 218491004517 Predicted helix-turn-helix motif with score 1633.000, SD 4.75 at aa 19-40, sequence GSFSGAAEALGLSQPAVSLQIR 218491004518 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 218491004519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491004520 Coenzyme A binding pocket [chemical binding]; other site 218491004521 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.9e-17 218491004522 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491004523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491004524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491004525 putative substrate translocation pore; other site 218491004526 12 probable transmembrane helices predicted for ECA0957 by TMHMM2.0 at aa 19-38, 42-64, 77-99, 103-125, 138-160, 165-187, 212-234, 239-261, 274-296, 301-323, 336-358 and 363-385 218491004527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 218491004528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 218491004529 Coenzyme A binding pocket [chemical binding]; other site 218491004530 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 0.024 218491004531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491004532 ABC transporter signature motif; other site 218491004533 Walker B; other site 218491004534 D-loop; other site 218491004535 H-loop/switch region; other site 218491004536 Possible plasmid/phage related DNA 218491004537 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004538 Pseudogene. This CDS appears to have a frameshift mutation. Similar to Escherichia coli, and Escherichia coli O157:H7 cytotoxic protein CcdB or LetB or protein G SWALL:CCDB_ECOLI (SWALL:P05703) (101 aa) fasta scores: E(): 5.9e-06, 44.06% id in 59 aa, and to Shigella flexneri CcdB protein SWALL:Q9AJV2 (EMBL:AL391753) (108 aa) fasta scores: E(): 8.7e-06, 42.37% id in 59 aa;cytotoxic protein (pseudogene) 218491004539 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 218491004540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491004541 non-specific DNA binding site [nucleotide binding]; other site 218491004542 salt bridge; other site 218491004543 sequence-specific DNA binding site [nucleotide binding]; other site 218491004544 HMMPfam hit to PF01381, DE Helix-turn-helix, score 1.2e-05 218491004545 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491004546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491004547 non-specific DNA binding site [nucleotide binding]; other site 218491004548 salt bridge; other site 218491004549 sequence-specific DNA binding site [nucleotide binding]; other site 218491004550 HMMPfam hit to PF01381, DE Helix-turn-helix, score 7.2e-08 218491004551 Predicted helix-turn-helix motif with score 1388.000, SD 3.91 at aa 25-46, sequence MTQENLANALGRPQSFVAKIEN 218491004552 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 218491004553 Predicted helix-turn-helix motif with score 1058.000, SD 2.79 at aa 20-41, sequence TTLAAVSRASGLASSTLANALT 218491004554 ornithine decarboxylase; Provisional; Region: PRK13578 218491004555 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 218491004556 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 218491004557 homodimer interface [polypeptide binding]; other site 218491004558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491004559 catalytic residue [active] 218491004560 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 218491004561 HMMPfam hit to PF03709, DE Orn/Lys/Arg decarboxylase, N-terminal domain, score 0.00047 218491004562 HMMPfam hit to PF01276, DE Orn/Lys/Arg decarboxylase, major domain, score 6.4e-295 218491004563 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 218491004564 HMMPfam hit to PF03711, DE Orn/Lys/Arg decarboxylase, C-terminal domain, score 2.3e-73 218491004565 classical (c) SDRs; Region: SDR_c; cd05233 218491004566 NAD(P) binding site [chemical binding]; other site 218491004567 active site 218491004568 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 4.9e-07 218491004569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491004570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491004571 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 218491004572 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 2.3e-06 218491004573 Predicted helix-turn-helix motif with score 1600.000, SD 4.64 at aa 65-86, sequence PSITDIAAAAQLSRATAYRYFP 218491004574 hypothetical protein; Provisional; Region: PRK02399 218491004575 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 218491004576 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 218491004577 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 218491004578 Signal peptide predicted for ECA0972 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.971 between residues 21 and 22; signal peptide 218491004579 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 218491004580 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218491004581 Helix-turn-helix domain; Region: HTH_18; pfam12833 218491004582 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.1e-05 218491004583 Predicted helix-turn-helix motif with score 1188.000, SD 3.23 at aa 285-306, sequence MTLQRLSRRMGIPLRRLSETIN 218491004584 7 probable transmembrane helices predicted for ECA0973 by TMHMM2.0 at aa 24-46, 66-83, 93-115, 128-145, 149-171, 183-205 and 215-237 218491004585 murein transglycosylase C; Provisional; Region: mltC; PRK11671 218491004586 Signal peptide predicted for ECA0974 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.570 between residues 21 and 22; signal peptide 218491004587 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 218491004588 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491004589 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491004590 catalytic residue [active] 218491004591 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 3e-46 218491004592 PS00922 Prokaryotic transglycosylases signature. 218491004593 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491004594 oxidative damage protection protein; Provisional; Region: PRK05408 218491004595 adenine DNA glycosylase; Provisional; Region: PRK10880 218491004596 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218491004597 minor groove reading motif; other site 218491004598 helix-hairpin-helix signature motif; other site 218491004599 substrate binding pocket [chemical binding]; other site 218491004600 active site 218491004601 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 218491004602 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 218491004603 DNA binding and oxoG recognition site [nucleotide binding] 218491004604 PS00764 Endonuclease III iron-sulfur binding region signature. 218491004605 HMMPfam hit to PF00730, DE HhH-GPD superfamily base excision DNA repair protein, score 2.2e-64 218491004606 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 107-128, sequence TTFDEVAALPGIGRSTAGAVLS 218491004607 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 218491004608 HMMPfam hit to PF02390, DE methyltransferase, score 9.3e-92 218491004609 hypothetical protein; Provisional; Region: PRK11702 218491004610 Predicted helix-turn-helix motif with score 1029.000, SD 2.69 at aa 69-90, sequence VCLQKIGHCTEDHRQLVSRWLE 218491004611 hypothetical protein; Provisional; Region: PRK10626 218491004612 Signal peptide predicted for ECA0979 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.856 between residues 19 and 20; signal peptide 218491004613 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 218491004614 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 218491004615 catalytic triad [active] 218491004616 putative active site [active] 218491004617 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 218491004618 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 218491004619 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218491004620 HMMPfam hit to PF00082, DE Subtilase family, score 2.3e-12 218491004621 PS00138 Serine proteases, subtilase family, serine active site. 218491004622 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03797, DE Autotransporter beta-domain, score 3.5e-24 218491004623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491004624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491004625 active site 218491004626 catalytic tetrad [active] 218491004627 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 1.5e-51 218491004628 Signal peptide predicted for ECA0982 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.874 between residues 24 and 25; signal peptide 218491004629 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218491004630 1 probable transmembrane helix predicted for ECA0982 by TMHMM2.0 at aa 5-24 218491004631 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491004632 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 218491004633 7 probable transmembrane helices predicted for ECA0983 by TMHMM2.0 at aa 15-37, 50-69, 84-100, 121-138, 153-175, 182-201 and 211-229 218491004634 HMMPfam hit to PF03741, DE Integral membrane protein TerC family, score 8.3e-99 218491004635 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 218491004636 putative DNA-binding cleft [nucleotide binding]; other site 218491004637 putative DNA clevage site; other site 218491004638 molecular lever; other site 218491004639 HMMPfam hit to PF02976, DE DNA mismatch repair enzyme MutH, score 2.1e-53 218491004640 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 218491004641 putative active site [active] 218491004642 Ap4A binding site [chemical binding]; other site 218491004643 nudix motif; other site 218491004644 putative metal binding site [ion binding]; other site 218491004645 HMMPfam hit to PF00293, DE NUDIX domain, score 5.5e-27 218491004646 PS00893 mutT domain signature. 218491004647 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 218491004648 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218491004649 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218491004650 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218491004651 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218491004652 HMMPfam hit to PF01590, DE GAF domain, score 1.4e-28 218491004653 HMMPfam hit to PF00391, DE PEP-utilising enzyme, mobile domain, score 3.9e-18 218491004654 PS00370 PEP-utilizing enzymes phosphorylation site signature. 218491004655 HMMPfam hit to PF02896, DE PEP-utilising enzyme, TIM barrel domain, score 8.4e-130 218491004656 PS00962 Ribosomal protein S2 signature 1. 218491004657 PS00742 PEP-utilizing enzymes signature 2. 218491004658 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 218491004659 HMMPfam hit to PF01790, DE Prolipoprotein diacylglyceryl transferase, score 1.5e-130 218491004660 7 probable transmembrane helices predicted for ECA0987 by TMHMM2.0 at aa 15-37, 58-80, 100-117, 124-146, 201-219, 226-243 and 258-280 218491004661 PS01311 Prolipoprotein diacylglyceryl transferase signature. 218491004662 thymidylate synthase; Reviewed; Region: thyA; PRK01827 218491004663 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 218491004664 dimerization interface [polypeptide binding]; other site 218491004665 active site 218491004666 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00303, DE Thymidylate synthase, score 7e-181 218491004667 PS00091 Thymidylate synthase active site. 218491004668 hypothetical protein; Provisional; Region: PRK10506 218491004669 Signal peptide predicted for ECA0989 by SignalP 2.0 HMM (Signal peptide probabilty 0.753) with cleavage site probability 0.354 between residues 33 and 34; signal peptide 218491004670 PS00409 Prokaryotic N-terminal methylation site. 218491004671 1 probable transmembrane helix predicted for ECA0989 by TMHMM2.0 at aa 13-35 218491004672 hypothetical protein; Provisional; Region: PRK10557 218491004673 PS00409 Prokaryotic N-terminal methylation site. 218491004674 Signal peptide predicted for ECA0991 by SignalP 2.0 HMM (Signal peptide probabilty 0.884) with cleavage site probability 0.329 between residues 31 and 32; signal peptide 218491004675 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 218491004676 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 218491004677 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 218491004678 PS00409 Prokaryotic N-terminal methylation site. 218491004679 1 probable transmembrane helix predicted for ECA0992 by TMHMM2.0 at aa 19-41 218491004680 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 218491004681 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 218491004682 Signal peptide predicted for ECA0994 by SignalP 2.0 HMM (Signal peptide probabilty 0.614) with cleavage site probability 0.613 between residues 24 and 25; signal peptide 218491004683 protease3; Provisional; Region: PRK15101 218491004684 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218491004685 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218491004686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218491004687 1 probable transmembrane helix predicted for ECA0994 by TMHMM2.0 at aa 13-32 218491004688 HMMPfam hit to PF00675, DE Insulinase (Peptidase family M16), score 6.8e-47 218491004689 PS00143 Insulinase family, zinc-binding region signature. 218491004690 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 218491004691 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 218491004692 HMMPfam hit to PF00580, DE UvrD/REP helicase, score 1.5e-102 218491004693 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004694 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 218491004695 AAA domain; Region: AAA_30; pfam13604 218491004696 Family description; Region: UvrD_C_2; pfam13538 218491004697 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491004699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491004700 DNA binding site [nucleotide binding] 218491004701 domain linker motif; other site 218491004702 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 218491004703 putative dimerization interface [polypeptide binding]; other site 218491004704 putative ligand binding site [chemical binding]; other site 218491004705 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 4e-08 218491004706 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 2.4e-09 218491004707 Predicted helix-turn-helix motif with score 2254.000, SD 6.86 at aa 15-36, sequence PTLEDVARAAGISPMTVSRALN 218491004708 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 218491004709 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 218491004710 active site pocket [active] 218491004711 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 3.8e-07 218491004712 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 7.3e-33 218491004713 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 218491004714 N-acetylglutamate synthase; Validated; Region: PRK05279 218491004715 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 218491004716 putative feedback inhibition sensing region; other site 218491004717 putative nucleotide binding site [chemical binding]; other site 218491004718 putative substrate binding site [chemical binding]; other site 218491004719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491004720 Coenzyme A binding pocket [chemical binding]; other site 218491004721 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.1e-07 218491004722 HMMPfam hit to PF00696, DE Amino acid kinase family, score 6.5e-31 218491004723 Signal peptide predicted for ECA1000 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 31 and 32; signal peptide 218491004724 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 218491004725 AMIN domain; Region: AMIN; pfam11741 218491004726 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218491004727 active site 218491004728 metal binding site [ion binding]; metal-binding site 218491004729 1 probable transmembrane helix predicted for ECA1000 by TMHMM2.0 at aa 21-43 218491004730 HMMPfam hit to PF01520, DE N-acetylmuramoyl-L-alanine amidase, score 4.2e-68 218491004731 murein transglycosylase A; Provisional; Region: mltA; PRK11162 218491004732 MltA specific insert domain; Region: MltA; smart00925 218491004733 3D domain; Region: 3D; pfam06725 218491004734 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491004735 HMMPfam hit to PF03562, DE MltA family, score 3.2e-152 218491004736 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 218491004737 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 218491004738 dimer interface [polypeptide binding]; other site 218491004739 active site 218491004740 catalytic residue [active] 218491004741 HMMPfam hit to PF00701, DE Dihydrodipicolinate synthetase family, score 4.2e-36 218491004742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491004743 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 6.1e-12 218491004744 Predicted helix-turn-helix motif with score 1365.000, SD 3.84 at aa 38-59, sequence TTIREITEATNVNVASVNYYFG 218491004745 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 218491004746 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 218491004747 metal binding site [ion binding]; metal-binding site 218491004748 putative dimer interface [polypeptide binding]; other site 218491004749 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 9e-76 218491004750 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218491004751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491004752 Walker A/P-loop; other site 218491004753 ATP binding site [chemical binding]; other site 218491004754 Q-loop/lid; other site 218491004755 ABC transporter signature motif; other site 218491004756 Walker B; other site 218491004757 D-loop; other site 218491004758 H-loop/switch region; other site 218491004759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491004760 Walker A/P-loop; other site 218491004761 ATP binding site [chemical binding]; other site 218491004762 Q-loop/lid; other site 218491004763 ABC transporter signature motif; other site 218491004764 Walker B; other site 218491004765 D-loop; other site 218491004766 H-loop/switch region; other site 218491004767 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491004768 HMMPfam hit to PF00005, DE ABC transporter, score 3.2e-63 218491004769 PS00211 ABC transporters family signature. 218491004770 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004771 HMMPfam hit to PF00005, DE ABC transporter, score 1.3e-61 218491004772 PS00211 ABC transporters family signature. 218491004773 PS00017 ATP/GTP-binding site motif A (P-loop). 218491004774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218491004775 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218491004776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491004777 dimer interface [polypeptide binding]; other site 218491004778 conserved gate region; other site 218491004779 putative PBP binding loops; other site 218491004780 ABC-ATPase subunit interface; other site 218491004781 5 probable transmembrane helices predicted for ECA1006 by TMHMM2.0 at aa 46-68, 114-136, 157-179, 230-252 and 273-295 218491004782 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.2e-08 218491004783 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491004784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491004785 dimer interface [polypeptide binding]; other site 218491004786 conserved gate region; other site 218491004787 putative PBP binding loops; other site 218491004788 ABC-ATPase subunit interface; other site 218491004789 6 probable transmembrane helices predicted for ECA1007 by TMHMM2.0 at aa 13-35, 110-132, 139-161, 191-213, 249-271 and 295-317 218491004790 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9.5e-09 218491004791 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491004792 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491004793 Signal peptide predicted for ECA1008 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 23 and 24; signal peptide 218491004794 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 218491004795 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 7e-72 218491004796 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 218491004797 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 218491004798 molybdopterin cofactor binding site [chemical binding]; other site 218491004799 substrate binding site [chemical binding]; other site 218491004800 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 218491004801 molybdopterin cofactor binding site; other site 218491004802 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 4.4e-125 218491004803 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 218491004804 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 2.6e-29 218491004805 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 218491004806 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 218491004807 putative ATP binding site [chemical binding]; other site 218491004808 putative substrate interface [chemical binding]; other site 218491004809 HMMPfam hit to PF00899, DE ThiF family, score 4.8e-53 218491004810 1 probable transmembrane helix predicted for ECA1010 by TMHMM2.0 at aa 235-257 218491004811 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 218491004812 HMMPfam hit to PF02657, DE Fe-S metabolism associated domain, score 5.2e-51 218491004813 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 218491004814 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 218491004815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491004816 catalytic residue [active] 218491004817 HMMPfam hit to PF00266, DE Aminotransferase class-V, score 1e-07 218491004818 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218491004819 Signal peptide predicted for ECA1013 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.455 between residues 19 and 20; signal peptide 218491004820 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 218491004821 1 probable transmembrane helix predicted for ECA1013 by TMHMM2.0 at aa 5-27 218491004822 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491004823 Signal peptide predicted for ECA1014 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.871 between residues 26 and 27; signal peptide 218491004824 2 probable transmembrane helices predicted for ECA1014 by TMHMM2.0 at aa 9-31 and 46-63 218491004825 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 218491004826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491004827 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 218491004828 dimerization interface [polypeptide binding]; other site 218491004829 substrate binding pocket [chemical binding]; other site 218491004830 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 7.1e-28 218491004831 Predicted helix-turn-helix motif with score 1791.000, SD 5.29 at aa 21-42, sequence LSFTRAAEELFVTQAAVSHQIK 218491004832 PS00044 Bacterial regulatory proteins, lysR family signature. 218491004833 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.5e-42 218491004834 hypothetical protein; Provisional; Region: PRK10873 218491004835 Signal peptide predicted for ECA1016 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.747 between residues 27 and 28; signal peptide 218491004836 4 probable transmembrane helices predicted for ECA1016 by TMHMM2.0 at aa 5-27, 42-60, 67-89 and 99-121 218491004837 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491004838 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 218491004839 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 218491004840 flap endonuclease-like protein; Provisional; Region: PRK09482 218491004841 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218491004842 active site 218491004843 metal binding site 1 [ion binding]; metal-binding site 218491004844 putative 5' ssDNA interaction site; other site 218491004845 metal binding site 3; metal-binding site 218491004846 metal binding site 2 [ion binding]; metal-binding site 218491004847 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218491004848 putative DNA binding site [nucleotide binding]; other site 218491004849 putative metal binding site [ion binding]; other site 218491004850 HMMPfam hit to PF01367, DE 5'-3' exonuclease, C-terminal SAM fold, score 8.7e-25 218491004851 HMMPfam hit to PF02739, DE 5'-3' exonuclease, N-terminal resolvase-like domain, score 9.6e-12 218491004852 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 218491004853 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 218491004854 HMMPfam hit to PF03641, DE Lysine decarboxylase family, score 8.7e-52 218491004855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 218491004856 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 218491004857 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 218491004858 HMMPfam hit to PF01227, DE GTP cyclohydrolase I, score 1.6e-05 218491004859 SecY interacting protein Syd; Provisional; Region: PRK04968 218491004860 Signal peptide predicted for ECA1022 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 21 and 22; signal peptide 218491004861 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 218491004862 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 218491004863 active site 218491004864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218491004865 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218491004866 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 218491004867 HMMPfam hit to PF01047, DE MarR family, score 7.9e-05 218491004868 Predicted helix-turn-helix motif with score 1061.000, SD 2.80 at aa 46-67, sequence CTQKYICERWSLPKQTVFSICK 218491004869 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 218491004870 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 218491004871 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218491004872 probable active site [active] 218491004873 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 1.3e-53 218491004874 PS01129 Rlu family of pseudouridine synthase signature. 218491004875 flavodoxin; Provisional; Region: PRK08105 218491004876 HMMPfam hit to PF00258, DE Flavodoxin, score 1.6e-33 218491004877 hypothetical protein; Provisional; Region: PRK13677 218491004878 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 218491004879 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 218491004880 trimer interface [polypeptide binding]; other site 218491004881 active site 218491004882 substrate binding site [chemical binding]; other site 218491004883 CoA binding site [chemical binding]; other site 218491004884 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 77 218491004885 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 4 218491004886 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 5.9 218491004887 PS00101 Hexapeptide-repeat containing-transferases signature. 218491004888 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1.1e+02 218491004889 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 5e+02 218491004890 PII uridylyl-transferase; Provisional; Region: PRK05007 218491004891 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 218491004892 metal binding triad; other site 218491004893 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 218491004894 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 218491004895 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 218491004896 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 218491004897 HMMPfam hit to PF01842, DE ACT domain, score 1.7e-07 218491004898 HMMPfam hit to PF01842, DE ACT domain, score 1.6e-06 218491004899 HMMPfam hit to PF01966, DE HD domain, score 7e-20 218491004900 HMMPfam hit to PF01909, DE Nucleotidyltransferase domain, score 4.5e-07 218491004901 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 218491004902 active site 218491004903 HMMPfam hit to PF00557, DE metallopeptidase family M24, score 7.5e-95 218491004904 PS00680 Methionine aminopeptidase subfamily 1 signature. 218491004905 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 218491004906 rRNA interaction site [nucleotide binding]; other site 218491004907 S8 interaction site; other site 218491004908 putative laminin-1 binding site; other site 218491004909 PS00962 Ribosomal protein S2 signature 1. 218491004910 HMMPfam hit to PF00318, DE Ribosomal protein S2, score 4.2e-126 218491004911 PS00963 Ribosomal protein S2 signature 2. 218491004912 elongation factor Ts; Provisional; Region: tsf; PRK09377 218491004913 UBA/TS-N domain; Region: UBA; pfam00627 218491004914 Elongation factor TS; Region: EF_TS; pfam00889 218491004915 Elongation factor TS; Region: EF_TS; pfam00889 218491004916 HMMPfam hit to PF00627, DE UBA/TS-N domain, score 1.6e-06 218491004917 HMMPfam hit to PF00889, DE Elongation factor TS, score 1e-107 218491004918 PS01127 Elongation factor Ts signature 2. 218491004919 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 218491004920 putative nucleotide binding site [chemical binding]; other site 218491004921 uridine monophosphate binding site [chemical binding]; other site 218491004922 homohexameric interface [polypeptide binding]; other site 218491004923 HMMPfam hit to PF00696, DE Amino acid kinase family, score 4.7e-61 218491004924 ribosome recycling factor; Reviewed; Region: frr; PRK00083 218491004925 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 218491004926 hinge region; other site 218491004927 HMMPfam hit to PF01765, DE Ribosome recycling factor, score 4.8e-98 218491004928 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 218491004929 Signal peptide predicted for ECA1035 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.525 between residues 22 and 23; signal peptide 218491004930 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 218491004931 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 218491004932 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 218491004933 HMMPfam hit to PF02670, DE 1-deoxy-D-xylulose 5-phosphate reductoisomerase, score 7.5e-229 218491004934 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 218491004935 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 218491004936 catalytic residue [active] 218491004937 putative FPP diphosphate binding site; other site 218491004938 putative FPP binding hydrophobic cleft; other site 218491004939 dimer interface [polypeptide binding]; other site 218491004940 putative IPP diphosphate binding site; other site 218491004941 HMMPfam hit to PF01255, DE undecaprenyl diphosphate synthase, score 1.8e-133 218491004942 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 218491004943 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 218491004944 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 218491004945 Signal peptide predicted for ECA1037 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.221 between residues 29 and 30; signal peptide 218491004946 6 probable transmembrane helices predicted for ECA1037 by TMHMM2.0 at aa 7-41, 56-78, 85-106, 121-143, 150-172 and 211-233 218491004947 HMMPfam hit to PF01148, DE Cytidylyltransferase family, score 1.5e-71 218491004948 PS01315 Phosphatidate cytidylyltransferase signature. 218491004949 zinc metallopeptidase RseP; Provisional; Region: PRK10779 218491004950 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218491004951 active site 218491004952 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 218491004953 protein binding site [polypeptide binding]; other site 218491004954 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 218491004955 protein binding site [polypeptide binding]; other site 218491004956 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218491004957 putative substrate binding region [chemical binding]; other site 218491004958 4 probable transmembrane helices predicted for ECA1038 by TMHMM2.0 at aa 2-21, 98-120, 377-399 and 427-446 218491004959 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491004960 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 2.2e-12 218491004961 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 218491004962 Signal peptide predicted for ECA1039 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.961 between residues 20 and 21; signal peptide 218491004963 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218491004964 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218491004965 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218491004966 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218491004967 Surface antigen; Region: Bac_surface_Ag; pfam01103 218491004968 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01103, DE Surface antigen, score 0 218491004969 periplasmic chaperone; Provisional; Region: PRK10780 218491004970 Signal peptide predicted for ECA1040 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 22 and 23; signal peptide 218491004971 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 218491004972 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03938, DE Outer membrane protein (OmpH-like), score 8.3e-37 218491004973 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 218491004974 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 218491004975 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 218491004976 trimer interface [polypeptide binding]; other site 218491004977 active site 218491004978 UDP-GlcNAc binding site [chemical binding]; other site 218491004979 lipid binding site [chemical binding]; lipid-binding site 218491004980 PS00101 Hexapeptide-repeat containing-transferases signature. 218491004981 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 11 218491004982 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.071 218491004983 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.061 218491004984 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1.3 218491004985 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 4.1 218491004986 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.15 218491004987 PS00101 Hexapeptide-repeat containing-transferases signature. 218491004988 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 7.6 218491004989 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 84 218491004990 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 218491004991 HMMPfam hit to PF01377, , score 7.3e-80 218491004992 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 218491004993 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 218491004994 active site 218491004995 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.0047 218491004996 PS00101 Hexapeptide-repeat containing-transferases signature. 218491004997 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 11 218491004998 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 53 218491004999 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 41 218491005000 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 42 218491005001 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 6 218491005002 PS00101 Hexapeptide-repeat containing-transferases signature. 218491005003 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 55 218491005004 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005005 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 218491005006 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 218491005007 HMMPfam hit to PF02684, DE Lipid-A-disaccharide synthetase, score 9.6e-171 218491005008 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 218491005009 RNA/DNA hybrid binding site [nucleotide binding]; other site 218491005010 active site 218491005011 HMMPfam hit to PF01351, DE Ribonuclease HII, score 1.5e-91 218491005012 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 218491005013 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 218491005014 putative active site [active] 218491005015 putative PHP Thumb interface [polypeptide binding]; other site 218491005016 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 218491005017 generic binding surface II; other site 218491005018 generic binding surface I; other site 218491005019 HMMPfam hit to PF02231, DE PHP domain N-terminal region, score 1.2e-26 218491005020 HMMPfam hit to PF02811, DE PHP domain C-terminal region, score 1.3e-33 218491005021 HMMPfam hit to PF01336, DE OB-fold nucleic acid binding domain, score 3.8e-08 218491005022 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 218491005023 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 218491005024 HMMPfam hit to PF03255, DE Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit, score 3.4e-104 218491005025 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 218491005026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491005027 putative metal binding site [ion binding]; other site 218491005028 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00903, DE Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 4.7e-18 218491005029 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 218491005030 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 218491005031 Ligand Binding Site [chemical binding]; other site 218491005032 TilS substrate binding domain; Region: TilS; pfam09179 218491005033 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 218491005034 Rho-binding antiterminator; Provisional; Region: PRK11625 218491005035 YaeQ protein; Region: YaeQ; pfam07152 218491005036 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 218491005037 NlpE N-terminal domain; Region: NlpE; pfam04170 218491005038 1 probable transmembrane helix predicted for ECA1052 by TMHMM2.0 at aa 37-59 218491005039 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005040 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 218491005041 MutS domain I; Region: MutS_I; pfam01624 218491005042 MutS domain II; Region: MutS_II; pfam05188 218491005043 MutS domain III; Region: MutS_III; pfam05192 218491005044 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 218491005045 Walker A/P-loop; other site 218491005046 ATP binding site [chemical binding]; other site 218491005047 Q-loop/lid; other site 218491005048 ABC transporter signature motif; other site 218491005049 Walker B; other site 218491005050 D-loop; other site 218491005051 H-loop/switch region; other site 218491005052 HMMPfam hit to PF00488, DE MutS domain V, score 9.3e-171 218491005053 PS00486 DNA mismatch repair proteins mutS family signature. 218491005054 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005055 HMMPfam hit to PF01624, DE MutS domain I, score 4.3e-219 218491005056 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491005057 Low %GC region 218491005058 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 218491005059 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 218491005060 active site 218491005061 catalytic residues [active] 218491005062 DNA binding site [nucleotide binding] 218491005063 Int/Topo IB signature motif; other site 218491005064 HMMPfam hit to PF00589, DE Phage integrase family, score 0.00092 218491005065 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 218491005066 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 218491005067 putative active site [active] 218491005068 putative NTP binding site [chemical binding]; other site 218491005069 putative nucleic acid binding site [nucleotide binding]; other site 218491005070 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 218491005071 putative active site [active] 218491005072 putative NTP binding site [chemical binding]; other site 218491005073 putative nucleic acid binding site [nucleotide binding]; other site 218491005074 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 218491005075 active site 218491005076 catalytic residues [active] 218491005077 DNA binding site [nucleotide binding] 218491005078 Int/Topo IB signature motif; other site 218491005079 HMMPfam hit to PF00589, DE Phage integrase family, score 0.00018 218491005080 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491005081 active site 218491005082 Int/Topo IB signature motif; other site 218491005083 DNA binding site [nucleotide binding] 218491005084 HMMPfam hit to PF00589, DE Phage integrase family, score 0.021 218491005085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 218491005086 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 218491005087 DNA binding site [nucleotide binding] 218491005088 active site 218491005089 Int/Topo IB signature motif; other site 218491005090 catalytic residues [active] 218491005091 HMMPfam hit to PF00589, DE Phage integrase family, score 1.4 218491005092 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005093 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 218491005094 HNH endonuclease; Region: HNH_5; pfam14279 218491005095 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 218491005096 1 probable transmembrane helix predicted for ECA1068 by TMHMM2.0 at aa 131-153 218491005097 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491005098 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 218491005099 HMMPfam hit to PF01977, DE 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 1.5e-149 218491005100 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 218491005101 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218491005102 putative C-terminal domain interface [polypeptide binding]; other site 218491005103 putative GSH binding site (G-site) [chemical binding]; other site 218491005104 putative dimer interface [polypeptide binding]; other site 218491005105 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 218491005106 putative N-terminal domain interface [polypeptide binding]; other site 218491005107 putative dimer interface [polypeptide binding]; other site 218491005108 putative substrate binding pocket (H-site) [chemical binding]; other site 218491005109 HMMPfam hit to PF00043, DE Glutathione S-transferase, C-terminal domain, score 7.1e-07 218491005110 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 3.6e-14 218491005111 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005112 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 218491005113 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491005114 Walker A/P-loop; other site 218491005115 ATP binding site [chemical binding]; other site 218491005116 Q-loop/lid; other site 218491005117 ABC transporter signature motif; other site 218491005118 Walker B; other site 218491005119 D-loop; other site 218491005120 H-loop/switch region; other site 218491005121 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218491005122 HMMPfam hit to PF00005, DE ABC transporter, score 5.9e-65 218491005123 PS00211 ABC transporters family signature. 218491005124 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005125 Signal peptide predicted for ECA1074 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.710 between residues 21 and 22; signal peptide 218491005126 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491005127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491005128 ABC-ATPase subunit interface; other site 218491005129 dimer interface [polypeptide binding]; other site 218491005130 putative PBP binding regions; other site 218491005131 HMMPfam hit to PF01032, DE FecCD transport family, score 5.6e-122 218491005132 10 probable transmembrane helices predicted for ECA1074 by TMHMM2.0 at aa 5-27, 51-73, 86-105, 109-131, 138-160, 180-202, 215-237, 241-263, 268-287 and 297-316 218491005133 Signal peptide predicted for ECA1075 by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.347 between residues 30 and 31; signal peptide 218491005134 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491005135 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491005136 ABC-ATPase subunit interface; other site 218491005137 dimer interface [polypeptide binding]; other site 218491005138 putative PBP binding regions; other site 218491005139 HMMPfam hit to PF01032, DE FecCD transport family, score 1.2e-120 218491005140 9 probable transmembrane helices predicted for ECA1075 by TMHMM2.0 at aa 12-34, 59-81, 88-110, 120-142, 151-173, 193-215, 244-266, 281-303 and 310-327 218491005141 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005142 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005143 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 218491005144 Signal peptide predicted for ECA1076 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.913 between residues 23 and 24; signal peptide 218491005145 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 218491005146 siderophore binding site; other site 218491005147 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 9.1e-59 218491005148 Signal peptide predicted for ECA1077 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.990 between residues 34 and 35; signal peptide 218491005149 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 218491005150 Secretin and TonB N terminus short domain; Region: STN; smart00965 218491005151 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491005152 N-terminal plug; other site 218491005153 ligand-binding site [chemical binding]; other site 218491005154 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 5.4e-23 218491005155 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491005156 fec operon regulator FecR; Reviewed; Region: PRK09774 218491005157 FecR protein; Region: FecR; pfam04773 218491005158 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 218491005159 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491005160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491005161 DNA binding residues [nucleotide binding] 218491005162 Predicted helix-turn-helix motif with score 1421.000, SD 4.03 at aa 137-158, sequence MAYAEIATRLNVSISSVKKYVA 218491005163 HMMPfam hit to PF00776, , score 0.015 218491005164 PS01063 Sigma-70 factors ECF subfamily signature. 218491005165 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 218491005166 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218491005167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491005168 Predicted helix-turn-helix motif with score 1079.000, SD 2.86 at aa 24-45, sequence LTLEHAGEIMGQATSALDRLEE 218491005169 1 probable transmembrane helix predicted for ECA1081 by TMHMM2.0 at aa 218-240 218491005170 HMMPfam hit to PF00563, DE EAL domain, score 9.3e-82 218491005171 PS00043 Bacterial regulatory proteins, gntR family signature. 218491005172 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 218491005173 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 218491005174 PhnA protein; Region: PhnA; pfam03831 218491005175 HMMPfam hit to PF03831, DE PhnA protein, score 6.4e-36 218491005176 Signal peptide predicted for ECA1083 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.484 between residues 22 and 23; signal peptide 218491005177 Transglycosylase SLT domain; Region: SLT_2; pfam13406 218491005178 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491005179 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491005180 catalytic residue [active] 218491005181 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005182 Signal peptide predicted for ECA1084 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.925 between residues 38 and 39; signal peptide 218491005183 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 218491005184 8 probable transmembrane helices predicted for ECA1084 by TMHMM2.0 at aa 7-29, 39-61, 68-87, 92-111, 123-145, 160-177, 190-207 and 217-239 218491005185 Signal peptide predicted for ECA1085 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.991 between residues 33 and 34; signal peptide 218491005186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491005187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491005188 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 218491005189 putative dimerization interface [polypeptide binding]; other site 218491005190 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 4.7e-34 218491005191 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.4e-10 218491005192 PS00044 Bacterial regulatory proteins, lysR family signature. 218491005193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491005194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491005195 metal binding site [ion binding]; metal-binding site 218491005196 active site 218491005197 I-site; other site 218491005198 HMMPfam hit to PF00990, DE GGDEF domain, score 7.1e-43 218491005199 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 218491005200 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 218491005202 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 218491005203 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218491005204 Esterase/lipase [General function prediction only]; Region: COG1647 218491005205 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005206 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005207 1 probable transmembrane helix predicted for ECA1090 by TMHMM2.0 at aa 13-32 218491005208 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 218491005209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491005210 DNA-binding site [nucleotide binding]; DNA binding site 218491005211 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218491005212 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 1.6e-25 218491005213 PS00043 Bacterial regulatory proteins, gntR family signature. 218491005214 mannonate dehydratase; Region: uxuA; TIGR00695 218491005215 mannonate dehydratase; Provisional; Region: PRK03906 218491005216 HMMPfam hit to PF03786, DE D-mannonate dehydratase (UxuA), score 1.1e-245 218491005217 Signal peptide predicted for ECA1094 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 21 and 22; signal peptide 218491005218 Pectate lyase; Region: Pectate_lyase; pfam03211 218491005219 HMMPfam hit to PF03211, DE Pectate lyase, score 1.1e-116 218491005220 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005221 Signal peptide predicted for ECA1095 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 26 and 27; signal peptide 218491005222 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 218491005223 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 218491005224 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00295, DE Glycosyl hydrolases family 28, score 2.9e-130 218491005225 PS00502 Polygalacturonase active site. 218491005226 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218491005227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491005228 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491005229 PS00543 HlyD family secretion proteins signature. 218491005230 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 0.0023 218491005231 1 probable transmembrane helix predicted for ECA1096 by TMHMM2.0 at aa 13-35 218491005232 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 218491005233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491005234 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 218491005235 Walker A/P-loop; other site 218491005236 ATP binding site [chemical binding]; other site 218491005237 Q-loop/lid; other site 218491005238 ABC transporter signature motif; other site 218491005239 Walker B; other site 218491005240 D-loop; other site 218491005241 H-loop/switch region; other site 218491005242 HMMPfam hit to PF00005, DE ABC transporter, score 3.9e-50 218491005243 PS00211 ABC transporters family signature. 218491005244 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005245 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 7.8e-13 218491005246 3 probable transmembrane helices predicted for ECA1097 by TMHMM2.0 at aa 164-186, 196-218 and 285-307 218491005247 Signal peptide predicted for ECA1098 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.964 between residues 56 and 57; signal peptide 218491005248 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 218491005249 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 8.4e-16 218491005250 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 6.6e-25 218491005251 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005252 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005253 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005254 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005255 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005256 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005257 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005258 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005259 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005260 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005261 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005262 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005263 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005264 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005265 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005266 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005267 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005268 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005269 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005270 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005271 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005272 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005273 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005274 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005275 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491005276 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005277 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 218491005278 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 218491005279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491005280 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 218491005281 Walker A/P-loop; other site 218491005282 ATP binding site [chemical binding]; other site 218491005283 Q-loop/lid; other site 218491005284 ABC transporter signature motif; other site 218491005285 Walker B; other site 218491005286 D-loop; other site 218491005287 H-loop/switch region; other site 218491005288 5 probable transmembrane helices predicted for ECA1101 by TMHMM2.0 at aa 13-35, 50-72, 122-144, 149-171 and 231-253 218491005289 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 0.019 218491005290 HMMPfam hit to PF00005, DE ABC transporter, score 2.6e-35 218491005291 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005292 PS00211 ABC transporters family signature. 218491005293 Signal peptide predicted for ECA1102 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 19 and 20; signal peptide 218491005294 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 218491005295 active site 218491005296 homodimer interface [polypeptide binding]; other site 218491005297 homotetramer interface [polypeptide binding]; other site 218491005298 PS00144 Asparaginase / glutaminase active site signature 1. 218491005299 HMMPfam hit to PF00710, DE Asparaginase, score 2.6e-151 218491005300 PS00917 Asparaginase / glutaminase active site signature 2. 218491005301 PS00589 PTS HPR component serine phosphorylation site signature. 218491005302 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 218491005303 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 218491005304 ADP binding site [chemical binding]; other site 218491005305 magnesium binding site [ion binding]; other site 218491005306 putative shikimate binding site; other site 218491005307 HMMPfam hit to PF01202, DE Shikimate kinase, score 3.9e-69 218491005308 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005309 PS01128 Shikimate kinase signature. 218491005310 hypothetical protein; Provisional; Region: PRK10579 218491005311 Cache domain; Region: Cache_1; pfam02743 218491005312 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491005313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491005314 dimerization interface [polypeptide binding]; other site 218491005315 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491005316 dimer interface [polypeptide binding]; other site 218491005317 putative CheW interface [polypeptide binding]; other site 218491005318 2 probable transmembrane helices predicted for ECA1105 by TMHMM2.0 at aa 38-60 and 303-325 218491005319 HMMPfam hit to PF02743, DE Cache domain, score 1.7e-11 218491005320 HMMPfam hit to PF00672, DE HAMP domain, score 9.8e-15 218491005321 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 2.9e-88 218491005322 recombination associated protein; Reviewed; Region: rdgC; PRK00321 218491005323 fructokinase; Reviewed; Region: PRK09557 218491005324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218491005325 nucleotide binding site [chemical binding]; other site 218491005326 Acetokinase family; Region: Acetate_kinase; cl17229 218491005327 HMMPfam hit to PF00480, DE ROK family, score 2e-72 218491005328 PS01125 ROK family signature. 218491005329 exonuclease subunit SbcC; Provisional; Region: PRK10246 218491005330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491005331 Walker A/P-loop; other site 218491005332 ATP binding site [chemical binding]; other site 218491005333 Q-loop/lid; other site 218491005334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491005335 Q-loop/lid; other site 218491005336 ABC transporter signature motif; other site 218491005337 Walker B; other site 218491005338 D-loop; other site 218491005339 H-loop/switch region; other site 218491005340 HMMPfam hit to PF02463, DE RecF/RecN/SMC N terminal domain, score 0.00034 218491005341 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005342 exonuclease subunit SbcD; Provisional; Region: PRK10966 218491005343 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 218491005344 active site 218491005345 metal binding site [ion binding]; metal-binding site 218491005346 DNA binding site [nucleotide binding] 218491005347 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 218491005348 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 2.2e-13 218491005349 transcriptional regulator PhoB; Provisional; Region: PRK10161 218491005350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491005351 active site 218491005352 phosphorylation site [posttranslational modification] 218491005353 intermolecular recognition site; other site 218491005354 dimerization interface [polypeptide binding]; other site 218491005355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491005356 DNA binding site [nucleotide binding] 218491005357 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 6.3e-38 218491005358 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 4.2e-32 218491005359 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 218491005360 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 218491005361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491005362 putative active site [active] 218491005363 heme pocket [chemical binding]; other site 218491005364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491005365 dimer interface [polypeptide binding]; other site 218491005366 phosphorylation site [posttranslational modification] 218491005367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491005368 ATP binding site [chemical binding]; other site 218491005369 Mg2+ binding site [ion binding]; other site 218491005370 G-X-G motif; other site 218491005371 1 probable transmembrane helix predicted for ECA1111 by TMHMM2.0 at aa 21-43 218491005372 HMMPfam hit to PF00989, DE PAS domain, score 6.9e-05 218491005373 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 2.1e-24 218491005374 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.2e-37 218491005375 Signal peptide predicted for ECA1112 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.924 between residues 21 and 22; signal peptide 218491005376 PBP superfamily domain; Region: PBP_like_2; cl17296 218491005377 HMMPfam hit to PF01449, , score 1e-29 218491005378 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 218491005379 substrate binding site [chemical binding]; other site 218491005380 THF binding site; other site 218491005381 zinc-binding site [ion binding]; other site 218491005382 HMMPfam hit to PF01717, DE Methionine synthase, vitamin-B12 independent, score 8.3e-05 218491005383 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 218491005384 Signal peptide predicted for ECA1114 by SignalP 2.0 HMM (Signal peptide probabilty 0.901) with cleavage site probability 0.751 between residues 24 and 25; signal peptide 218491005385 12 probable transmembrane helices predicted for ECA1114 by TMHMM2.0 at aa 13-35, 46-68, 81-103, 118-140, 147-169, 189-211, 223-245, 283-305, 317-339, 343-365, 370-387 and 409-426 218491005386 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005387 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005388 Signal peptide predicted for ECA1115 by SignalP 2.0 HMM (Signal peptide probabilty 0.659) with cleavage site probability 0.434 between residues 37 and 38; signal peptide 218491005389 putative proline-specific permease; Provisional; Region: proY; PRK10580 218491005390 Spore germination protein; Region: Spore_permease; cl17796 218491005391 HMMPfam hit to PF00324, DE Amino acid permease, score 3.1e-156 218491005392 12 probable transmembrane helices predicted for ECA1115 by TMHMM2.0 at aa 36-58, 62-81, 101-123, 138-160, 172-194, 214-236, 257-279, 294-316, 347-369, 374-396, 418-440 and 445-463 218491005393 PS00218 Amino acid permeases signature. 218491005394 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 218491005395 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218491005396 HMMPfam hit to PF00924, DE Mechanosensitive ion channel, score 2.6e-43 218491005397 5 probable transmembrane helices predicted for ECA1116 by TMHMM2.0 at aa 45-67, 100-122, 137-159, 172-194 and 198-215 218491005398 peroxidase; Provisional; Region: PRK15000 218491005399 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 218491005400 dimer interface [polypeptide binding]; other site 218491005401 decamer (pentamer of dimers) interface [polypeptide binding]; other site 218491005402 catalytic triad [active] 218491005403 peroxidatic and resolving cysteines [active] 218491005404 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005405 HMMPfam hit to PF00578, DE AhpC/TSA family, score 1.3e-54 218491005406 Protein of unknown function, DUF479; Region: DUF479; cl01203 218491005407 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 218491005408 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 218491005409 HMMPfam hit to PF02547, DE Queuosine biosynthesis protein, score 1.2e-125 218491005410 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 218491005411 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 218491005412 HMMPfam hit to PF01702, DE Queuine tRNA-ribosyltransferase, score 8.4e-163 218491005413 Signal peptide predicted for ECA1121 by SignalP 2.0 HMM (Signal peptide probabilty 0.672) with cleavage site probability 0.413 between residues 16 and 17; signal peptide 218491005414 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 218491005415 HMMPfam hit to PF02699, DE Preprotein translocase subunit, score 3.3e-40 218491005416 1 probable transmembrane helix predicted for ECA1121 by TMHMM2.0 at aa 20-39 218491005417 Signal peptide predicted for ECA1122 by SignalP 2.0 HMM (Signal peptide probabilty 0.935) with cleavage site probability 0.597 between residues 24 and 25; signal peptide 218491005418 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 218491005419 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 218491005420 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 218491005421 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 218491005422 6 probable transmembrane helices predicted for ECA1122 by TMHMM2.0 at aa 7-29, 450-472, 475-497, 502-524, 548-570 and 580-602 218491005423 PS00761 Signal peptidases I signature 3. 218491005424 HMMPfam hit to PF02355, DE Protein export membrane protein, score 0.0012 218491005425 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 218491005426 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 218491005427 Protein export membrane protein; Region: SecD_SecF; pfam02355 218491005428 6 probable transmembrane helices predicted for ECA1123 by TMHMM2.0 at aa 24-46, 141-163, 170-192, 197-216, 247-269 and 274-296 218491005429 HMMPfam hit to PF02355, DE Protein export membrane protein, score 2.1e-120 218491005430 hypothetical protein; Provisional; Region: PRK11530 218491005431 Signal peptide predicted for ECA1124 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.455 between residues 21 and 22; signal peptide 218491005432 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005433 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 218491005434 ATP cone domain; Region: ATP-cone; pfam03477 218491005435 PS00190 Cytochrome c family heme-binding site signature. 218491005436 HMMPfam hit to PF03477, DE ATP cone domain, score 3.5e-30 218491005437 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 218491005438 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 218491005439 catalytic motif [active] 218491005440 Zn binding site [ion binding]; other site 218491005441 RibD C-terminal domain; Region: RibD_C; cl17279 218491005442 HMMPfam hit to PF00383, DE Cytidine and deoxycytidylate deaminase zinc-binding region, score 4.9e-46 218491005443 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218491005444 HMMPfam hit to PF01872, DE RibD C-terminal domain, score 3.3e-85 218491005445 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 218491005446 homopentamer interface [polypeptide binding]; other site 218491005447 active site 218491005448 HMMPfam hit to PF00885, DE 6,7-dimethyl-8-ribityllumazine synthase, score 1e-83 218491005449 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 218491005450 putative RNA binding site [nucleotide binding]; other site 218491005451 HMMPfam hit to PF01029, DE NusB family, score 1.5e-44 218491005452 thiamine monophosphate kinase; Provisional; Region: PRK05731 218491005453 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 218491005454 ATP binding site [chemical binding]; other site 218491005455 dimerization interface [polypeptide binding]; other site 218491005456 HMMPfam hit to PF02769, DE AIR synthase related protein, C-terminal domain, score 0.0037 218491005457 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 218491005458 tetramer interfaces [polypeptide binding]; other site 218491005459 binuclear metal-binding site [ion binding]; other site 218491005460 3 probable transmembrane helices predicted for ECA1130 by TMHMM2.0 at aa 26-48, 63-85 and 158-177 218491005461 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 218491005462 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 218491005463 TPP-binding site; other site 218491005464 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218491005465 PYR/PP interface [polypeptide binding]; other site 218491005466 dimer interface [polypeptide binding]; other site 218491005467 TPP binding site [chemical binding]; other site 218491005468 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218491005469 HMMPfam hit to PF02780, DE Transketolase, C-terminal domain, score 2.2e-37 218491005470 HMMPfam hit to PF02779, DE Transketolase, pyridine binding domain, score 7.3e-57 218491005471 PS00802 Transketolase signature 2. 218491005472 PS00801 Transketolase signature 1. 218491005473 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218491005474 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218491005475 substrate binding pocket [chemical binding]; other site 218491005476 chain length determination region; other site 218491005477 substrate-Mg2+ binding site; other site 218491005478 catalytic residues [active] 218491005479 aspartate-rich region 1; other site 218491005480 active site lid residues [active] 218491005481 aspartate-rich region 2; other site 218491005482 HMMPfam hit to PF00348, DE Polyprenyl synthetase, score 3.3e-112 218491005483 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005484 PS00444 Polyprenyl synthetases signature 2. 218491005485 PS00723 Polyprenyl synthetases signature 1. 218491005486 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 218491005487 HMMPfam hit to PF02609, DE Exonuclease VII small subunit, score 1.2e-29 218491005488 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 218491005489 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 218491005490 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 218491005491 Ligand Binding Site [chemical binding]; other site 218491005492 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 218491005493 active site residue [active] 218491005494 HMMPfam hit to PF02926, DE THUMP domain, score 6.1e-24 218491005495 HMMPfam hit to PF02568, DE Thiamine biosynthesis protein (ThiI), score 1.6e-103 218491005496 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 218491005497 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 218491005498 conserved cys residue [active] 218491005499 HMMPfam hit to PF01965, DE DJ-1/PfpI family, score 1e-42 218491005500 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 218491005501 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 218491005502 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 218491005503 HMMPfam hit to PF02558, DE Ketopantoate reductase PanE/ApbA, score 7.2e-67 218491005504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 218491005505 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 218491005506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491005507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491005508 putative substrate translocation pore; other site 218491005509 12 probable transmembrane helices predicted for ECA1138 by TMHMM2.0 at aa 13-35, 50-72, 79-97, 101-123, 136-158, 168-190, 214-236, 251-273, 280-297, 302-324, 337-359 and 364-386 218491005510 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00039 218491005511 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 218491005512 UbiA prenyltransferase family; Region: UbiA; pfam01040 218491005513 9 probable transmembrane helices predicted for ECA1139 by TMHMM2.0 at aa 13-32, 37-59, 79-101, 106-125, 132-154, 159-181, 208-230, 234-251 and 264-286 218491005514 HMMPfam hit to PF01040, DE UbiA prenyltransferase family, score 4.7e-77 218491005515 PS00943 UbiA prenyltransferase family signature. 218491005516 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 218491005517 3 probable transmembrane helices predicted for ECA1140 by TMHMM2.0 at aa 20-42, 47-66 and 79-101 218491005518 HMMPfam hit to PF03626, DE Prokaryotic Cytochrome C oxidase subunit IV, score 2.5e-47 218491005519 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005520 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 218491005521 Subunit I/III interface [polypeptide binding]; other site 218491005522 Subunit III/IV interface [polypeptide binding]; other site 218491005523 HMMPfam hit to PF00510, DE Cytochrome c oxidase subunit III, score 3.7e-06 218491005524 5 probable transmembrane helices predicted for ECA1141 by TMHMM2.0 at aa 29-51, 66-88, 101-123, 138-160 and 181-203 218491005525 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 218491005526 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 218491005527 D-pathway; other site 218491005528 Putative ubiquinol binding site [chemical binding]; other site 218491005529 Low-spin heme (heme b) binding site [chemical binding]; other site 218491005530 Putative water exit pathway; other site 218491005531 Binuclear center (heme o3/CuB) [ion binding]; other site 218491005532 K-pathway; other site 218491005533 Putative proton exit pathway; other site 218491005534 14 probable transmembrane helices predicted for ECA1142 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 457-479, 494-516 and 590-612 218491005535 HMMPfam hit to PF00115, DE Cytochrome C and Quinol oxidase polypeptide I, score 5.1e-257 218491005536 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 218491005537 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 218491005538 Signal peptide predicted for ECA1143 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.928 between residues 28 and 29; signal peptide 218491005539 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 218491005540 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 218491005541 3 probable transmembrane helices predicted for ECA1143 by TMHMM2.0 at aa 13-30, 45-67 and 88-108 218491005542 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005543 Signal peptide predicted for ECA1144 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.618 between residues 37 and 38; signal peptide 218491005544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491005545 muropeptide transporter; Reviewed; Region: ampG; PRK11902 218491005546 putative substrate translocation pore; other site 218491005547 14 probable transmembrane helices predicted for ECA1144 by TMHMM2.0 at aa 13-35, 50-69, 82-101, 106-128, 149-166, 176-198, 228-250, 260-282, 287-309, 319-341, 354-376, 380-402, 428-447 and 462-481 218491005548 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0097 218491005549 Signal peptide predicted for ECA1145 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.340 between residues 22 and 23; signal peptide 218491005550 hypothetical protein; Provisional; Region: PRK11627 218491005551 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 218491005552 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03923, DE Uncharacterized lipoprotein, score 1.9e-11 218491005553 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005554 transcriptional regulator BolA; Provisional; Region: PRK11628 218491005555 HMMPfam hit to PF01722, DE BolA-like protein, score 1.1e-33 218491005556 trigger factor; Provisional; Region: tig; PRK01490 218491005557 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218491005558 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 218491005559 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 218491005560 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218491005561 oligomer interface [polypeptide binding]; other site 218491005562 active site residues [active] 218491005563 HMMPfam hit to PF00574, DE Clp protease, score 4.7e-132 218491005564 PS00381 Endopeptidase Clp serine active site. 218491005565 PS00382 Endopeptidase Clp histidine active site. 218491005566 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 218491005567 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 218491005568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491005569 Walker A motif; other site 218491005570 ATP binding site [chemical binding]; other site 218491005571 Walker B motif; other site 218491005572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 218491005573 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 1.5e-23 218491005574 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005575 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 218491005576 Found in ATP-dependent protease La (LON); Region: LON; smart00464 218491005577 Found in ATP-dependent protease La (LON); Region: LON; smart00464 218491005578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491005579 Walker A motif; other site 218491005580 ATP binding site [chemical binding]; other site 218491005581 Walker B motif; other site 218491005582 arginine finger; other site 218491005583 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218491005584 HMMPfam hit to PF02190, DE ATP-dependent protease La (LON) domain, score 1.2e-73 218491005585 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 4.3e-42 218491005586 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005587 PS01046 ATP-dependent serine proteases, lon family, serine active site. 218491005588 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218491005589 IHF dimer interface [polypeptide binding]; other site 218491005590 IHF - DNA interface [nucleotide binding]; other site 218491005591 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00216, DE Bacterial DNA-binding protein, score 2e-50 218491005592 PS00045 Bacterial histone-like DNA-binding proteins signature. 218491005593 periplasmic folding chaperone; Provisional; Region: PRK10788 218491005594 SurA N-terminal domain; Region: SurA_N_3; cl07813 218491005595 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 218491005596 1 probable transmembrane helix predicted for ECA1152 by TMHMM2.0 at aa 31-53 218491005597 PS00018 EF-hand calcium-binding domain. 218491005598 HMMPfam hit to PF00639, DE PPIC-type PPIASE domain, score 8.9e-15 218491005599 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 218491005600 Signal peptide predicted for ECA1153 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.940 between residues 26 and 27; signal peptide 218491005601 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 218491005602 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 218491005603 active site 218491005604 HMMPfam hit to PF03061, DE Thioesterase superfamily, score 5.9e-34 218491005605 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 218491005606 Ligand Binding Site [chemical binding]; other site 218491005607 PS00190 Cytochrome c family heme-binding site signature. 218491005608 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 218491005609 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 218491005610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491005611 catalytic residue [active] 218491005612 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 2.7e-48 218491005613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491005614 dimerization interface [polypeptide binding]; other site 218491005615 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 218491005616 putative DNA binding site [nucleotide binding]; other site 218491005617 putative Zn2+ binding site [ion binding]; other site 218491005618 AsnC family; Region: AsnC_trans_reg; pfam01037 218491005619 HMMPfam hit to PF01037, DE AsnC family, score 1.3e-47 218491005620 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 218491005621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491005622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491005623 Walker A/P-loop; other site 218491005624 ATP binding site [chemical binding]; other site 218491005625 Q-loop/lid; other site 218491005626 ABC transporter signature motif; other site 218491005627 Walker B; other site 218491005628 D-loop; other site 218491005629 H-loop/switch region; other site 218491005630 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 4.3e-49 218491005631 6 probable transmembrane helices predicted for ECA1158 by TMHMM2.0 at aa 21-43, 58-77, 129-151, 156-175, 247-269 and 279-301 218491005632 HMMPfam hit to PF00005, DE ABC transporter, score 6.2e-48 218491005633 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005634 PS00211 ABC transporters family signature. 218491005635 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 218491005636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491005637 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 218491005638 Walker A/P-loop; other site 218491005639 ATP binding site [chemical binding]; other site 218491005640 Q-loop/lid; other site 218491005641 ABC transporter signature motif; other site 218491005642 Walker B; other site 218491005643 D-loop; other site 218491005644 H-loop/switch region; other site 218491005645 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 4.3e-32 218491005646 5 probable transmembrane helices predicted for ECA1159 by TMHMM2.0 at aa 29-51, 61-83, 138-160, 165-187 and 250-272 218491005647 HMMPfam hit to PF00005, DE ABC transporter, score 2e-48 218491005648 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005649 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 218491005650 Nitrogen regulatory protein P-II; Region: P-II; smart00938 218491005651 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00543, DE Nitrogen regulatory protein P-II, score 5.7e-47 218491005652 PS00496 P-II protein urydylation site. 218491005653 PS00638 P-II protein C-terminal region signature. 218491005654 Signal peptide predicted for ECA1161 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 24 and 25; signal peptide 218491005655 ammonium transporter; Provisional; Region: PRK10666 218491005656 12 probable transmembrane helices predicted for ECA1161 by TMHMM2.0 at aa 7-25, 35-57, 70-92, 122-144, 151-173, 188-207, 220-239, 249-271, 278-300, 304-326, 339-361 and 376-398 218491005657 HMMPfam hit to PF00909, DE Ammonium Transporter Family, score 1.5e-173 218491005658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005659 PS01219 Ammonium transporters signature. 218491005660 acyl-CoA thioesterase II; Provisional; Region: PRK10526 218491005661 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 218491005662 active site 218491005663 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 218491005664 catalytic triad [active] 218491005665 dimer interface [polypeptide binding]; other site 218491005666 HMMPfam hit to PF02551, DE Acyl-CoA thioesterase, score 8.4e-56 218491005667 HMMPfam hit to PF02551, DE Acyl-CoA thioesterase, score 2.3e-40 218491005668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 218491005669 Signal peptide predicted for ECA1163 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.679 between residues 20 and 21; signal peptide 218491005670 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005671 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218491005672 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 218491005673 DNA binding site [nucleotide binding] 218491005674 active site 218491005675 HMMPfam hit to PF01035, DE 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 1.8e-28 218491005676 gene expression modulator; Provisional; Region: PRK10945 218491005677 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 218491005678 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 218491005679 HMMPfam hit to PF00444, DE Ribosomal protein L36, score 0.0012 218491005680 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 218491005681 HMMPfam hit to PF01197, DE Ribosomal protein L31, score 3e-05 218491005682 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 218491005683 Protein export membrane protein; Region: SecD_SecF; cl14618 218491005684 Protein export membrane protein; Region: SecD_SecF; cl14618 218491005685 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 0 218491005686 11 probable transmembrane helices predicted for ECA1169 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 541-563, 872-891, 898-920, 925-947, 974-996 and 1006-1028 218491005687 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005688 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 218491005689 Signal peptide predicted for ECA1170 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.520 between residues 24 and 25; signal peptide 218491005690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491005691 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491005692 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 1.8e-82 218491005693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005694 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 218491005695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491005696 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 218491005697 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 2.4e-22 218491005698 PS01081 Bacterial regulatory proteins, tetR family signature. 218491005699 Predicted helix-turn-helix motif with score 2119.000, SD 6.40 at aa 32-53, sequence TSLSDIATAAGVTRGAIYWHFK 218491005700 hypothetical protein; Provisional; Region: PRK11038 218491005701 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 218491005702 Signal peptide predicted for ECA1174 by SignalP 2.0 HMM (Signal peptide probabilty 0.865) with cleavage site probability 0.360 between residues 19 and 20; signal peptide 218491005703 hypothetical protein; Provisional; Region: PRK10527 218491005704 3 probable transmembrane helices predicted for ECA1174 by TMHMM2.0 at aa 7-29, 77-94 and 101-120 218491005705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491005706 active site 218491005707 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 2.2e-48 218491005708 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491005709 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 218491005710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491005711 Walker A motif; other site 218491005712 ATP binding site [chemical binding]; other site 218491005713 Walker B motif; other site 218491005714 DNA polymerase III subunit delta'; Validated; Region: PRK08485 218491005715 arginine finger; other site 218491005716 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 218491005717 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 218491005718 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 218491005719 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 7.6e-09 218491005720 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005721 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491005722 hypothetical protein; Validated; Region: PRK00153 218491005723 HMMPfam hit to PF02575, DE Uncharacterised BCR, YbaB family COG0718, score 3.9e-49 218491005724 recombination protein RecR; Reviewed; Region: recR; PRK00076 218491005725 RecR protein; Region: RecR; pfam02132 218491005726 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 218491005727 putative active site [active] 218491005728 putative metal-binding site [ion binding]; other site 218491005729 tetramer interface [polypeptide binding]; other site 218491005730 HMMPfam hit to PF02132, DE RecR protein, score 4.3e-21 218491005731 PS01300 RecR protein signature. 218491005732 HMMPfam hit to PF01751, DE Toprim domain, score 1.7e-16 218491005733 heat shock protein 90; Provisional; Region: PRK05218 218491005734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491005735 ATP binding site [chemical binding]; other site 218491005736 Mg2+ binding site [ion binding]; other site 218491005737 G-X-G motif; other site 218491005738 PS00298 Heat shock hsp90 proteins family signature. 218491005739 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.9e-14 218491005740 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00183, DE Hsp90 protein, score 3.1e-226 218491005741 adenylate kinase; Reviewed; Region: adk; PRK00279 218491005742 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 218491005743 AMP-binding site [chemical binding]; other site 218491005744 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 218491005745 HMMPfam hit to PF00406, DE Adenylate kinase, score 9e-121 218491005746 PS00113 Adenylate kinase signature. 218491005747 ferrochelatase; Reviewed; Region: hemH; PRK00035 218491005748 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 218491005749 C-terminal domain interface [polypeptide binding]; other site 218491005750 active site 218491005751 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 218491005752 active site 218491005753 N-terminal domain interface [polypeptide binding]; other site 218491005754 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00762, DE Ferrochelatase, score 3.9e-144 218491005755 PS00534 Ferrochelatase signature. 218491005756 putative cation:proton antiport protein; Provisional; Region: PRK10669 218491005757 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 218491005758 TrkA-N domain; Region: TrkA_N; pfam02254 218491005759 PS00589 PTS HPR component serine phosphorylation site signature. 218491005760 HMMPfam hit to PF02254, DE TrkA-N domain, score 3.1e-31 218491005761 HMMPfam hit to PF00999, DE Sodium/hydrogen exchanger family, score 1.1e-09 218491005762 12 probable transmembrane helices predicted for ECA1182 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 186-208, 229-251, 281-300, 302-324, 339-361 and 368-387 218491005763 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005764 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 218491005765 Signal peptide predicted for ECA1184 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.776 between residues 25 and 26; signal peptide 218491005766 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 218491005767 active site 218491005768 metal binding site [ion binding]; metal-binding site 218491005769 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218491005770 1 probable transmembrane helix predicted for ECA1184 by TMHMM2.0 at aa 7-26 218491005771 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 2.7e-20 218491005772 PS00785 5'-nucleotidase signature 1. 218491005773 PS00786 5'-nucleotidase signature 2. 218491005774 HMMPfam hit to PF02872, DE 5'-nucleotidase, C-terminal domain, score 1.1e-45 218491005775 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 218491005776 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218491005777 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 218491005778 sugar binding site [chemical binding]; other site 218491005779 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218491005780 HMMPfam hit to PF00754, DE F5/8 type C domain, score 0.11 218491005781 Signal peptide predicted for ECA1187 by SignalP 2.0 HMM (Signal peptide probabilty 0.859) with cleavage site probability 0.569 between residues 27 and 28; signal peptide 218491005782 carbon starvation protein A; Provisional; Region: PRK15015 218491005783 Carbon starvation protein CstA; Region: CstA; pfam02554 218491005784 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 218491005785 16 probable transmembrane helices predicted for ECA1187 by TMHMM2.0 at aa 7-29, 34-56, 91-113, 118-140, 161-183, 193-215, 220-242, 257-279, 286-305, 325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 666-688 218491005786 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491005787 HMMPfam hit to PF02554, DE Carbon starvation protein CstA, score 1.2e-271 218491005788 Uncharacterized small protein [Function unknown]; Region: COG2879 218491005789 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 218491005790 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 218491005791 P-loop, Walker A motif; other site 218491005792 Base recognition motif; other site 218491005793 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 218491005794 HMMPfam hit to PF02492, DE Cobalamin synthesis protein/P47K, score 1.9e-115 218491005795 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005796 Signal peptide predicted for ECA1190 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 25 and 26; signal peptide 218491005797 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 218491005798 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 218491005799 HMMPfam hit to PF00295, DE Glycosyl hydrolases family 28, score 4.7e-31 218491005800 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 218491005801 putative deacylase active site [active] 218491005802 Predicted helix-turn-helix motif with score 1025.000, SD 2.68 at aa 28-49, sequence NFGEEAARKLGLNKEQVYKTLL 218491005803 Signal peptide predicted for ECA1192 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.986 between residues 21 and 22; signal peptide 218491005804 TraB family; Region: TraB; cl12050 218491005805 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218491005806 metal-binding site [ion binding] 218491005807 copper exporting ATPase; Provisional; Region: copA; PRK10671 218491005808 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218491005809 metal-binding site [ion binding] 218491005810 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218491005811 metal-binding site [ion binding] 218491005812 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218491005813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491005814 motif II; other site 218491005815 8 probable transmembrane helices predicted for ECA1193 by TMHMM2.0 at aa 259-281, 291-313, 326-345, 355-374, 508-530, 535-557, 850-869 and 874-896 218491005816 Predicted helix-turn-helix motif with score 1226.000, SD 3.36 at aa 827-848, sequence HSLHGVADALELSNATLRNMKQ 218491005817 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 3.9e-38 218491005818 PS01229 Hypothetical cof family signature 2. 218491005819 PS00154 E1-E2 ATPases phosphorylation site. 218491005820 HMMPfam hit to PF00122, DE E1-E2 ATPase, score 3e-84 218491005821 HMMPfam hit to PF00403, DE Heavy-metal-associated domain, score 6.3e-22 218491005822 PS01047 Heavy-metal-associated domain. 218491005823 HMMPfam hit to PF00403, DE Heavy-metal-associated domain, score 2.9e-13 218491005824 HMMPfam hit to PF00403, DE Heavy-metal-associated domain, score 4.8e-12 218491005825 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 218491005826 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 218491005827 DNA binding residues [nucleotide binding] 218491005828 dimer interface [polypeptide binding]; other site 218491005829 copper binding site [ion binding]; other site 218491005830 Predicted helix-turn-helix motif with score 1702.000, SD 4.98 at aa 1-22, sequence MNISDVAKKTGLSSKTIRFYEE 218491005831 HMMPfam hit to PF00376, DE MerR family regulatory protein, score 1.2e-11 218491005832 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 218491005833 2 probable transmembrane helices predicted for ECA1195 by TMHMM2.0 at aa 12-34 and 54-76 218491005834 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 218491005835 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 218491005836 HMMPfam hit to PF01145, DE SPFH domain / Band 7 family, score 3.8e-74 218491005837 PS01270 Band 7 protein family signature. 218491005838 1 probable transmembrane helix predicted for ECA1196 by TMHMM2.0 at aa 7-29 218491005839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218491005840 catalytic loop [active] 218491005841 iron binding site [ion binding]; other site 218491005842 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 4.2e-06 218491005843 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 218491005844 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218491005845 dimer interface [polypeptide binding]; other site 218491005846 putative radical transfer pathway; other site 218491005847 diiron center [ion binding]; other site 218491005848 tyrosyl radical; other site 218491005849 HMMPfam hit to PF00268, DE Ribonucleotide reductase, small chain, score 9.1e-142 218491005850 PS00368 Ribonucleotide reductase small subunit signature. 218491005851 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 218491005852 ATP cone domain; Region: ATP-cone; pfam03477 218491005853 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218491005854 active site 218491005855 dimer interface [polypeptide binding]; other site 218491005856 catalytic residues [active] 218491005857 effector binding site; other site 218491005858 R2 peptide binding site; other site 218491005859 HMMPfam hit to PF02867, DE Ribonucleotide reductase, barrel domain, score 1.8e-256 218491005860 PS00089 Ribonucleotide reductase large subunit signature. 218491005861 HMMPfam hit to PF00317, DE Ribonucleotide reductase, all-alpha domain, score 2.8e-23 218491005862 HMMPfam hit to PF03477, DE ATP cone domain, score 3.5e-22 218491005863 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 218491005864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491005865 S-adenosylmethionine binding site [chemical binding]; other site 218491005866 HMMPfam hit to PF01209, DE ubiE/COQ5 methyltransferase family, score 0.0013 218491005867 DNA gyrase subunit A; Validated; Region: PRK05560 218491005868 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 218491005869 CAP-like domain; other site 218491005870 active site 218491005871 primary dimer interface [polypeptide binding]; other site 218491005872 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218491005873 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218491005874 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218491005875 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218491005876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218491005877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218491005878 HMMPfam hit to PF00521, DE DNA gyrase/topoisomerase IV, subunit A, score 0 218491005879 Signal peptide predicted for ECA1202 by SignalP 2.0 HMM (Signal peptide probabilty 0.691) with cleavage site probability 0.282 between residues 38 and 39; signal peptide 218491005880 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 218491005881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491005882 dimer interface [polypeptide binding]; other site 218491005883 phosphorylation site [posttranslational modification] 218491005884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491005885 ATP binding site [chemical binding]; other site 218491005886 Mg2+ binding site [ion binding]; other site 218491005887 G-X-G motif; other site 218491005888 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 218491005889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491005890 active site 218491005891 phosphorylation site [posttranslational modification] 218491005892 intermolecular recognition site; other site 218491005893 dimerization interface [polypeptide binding]; other site 218491005894 2 probable transmembrane helices predicted for ECA1202 by TMHMM2.0 at aa 15-37 and 314-336 218491005895 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 3.2e-20 218491005896 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.9e-38 218491005897 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.9e-34 218491005898 transcriptional regulator RcsB; Provisional; Region: PRK10840 218491005899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491005900 active site 218491005901 phosphorylation site [posttranslational modification] 218491005902 intermolecular recognition site; other site 218491005903 dimerization interface [polypeptide binding]; other site 218491005904 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491005905 DNA binding residues [nucleotide binding] 218491005906 dimerization interface [polypeptide binding]; other site 218491005907 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 3.1e-19 218491005908 PS00622 Bacterial regulatory proteins, luxR family signature. 218491005909 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 166-187, sequence FLVTEIAKKLNRSIKTISSQKK 218491005910 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 6.2e-30 218491005911 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 218491005912 Signal peptide predicted for ECA1204 by SignalP 2.0 HMM (Signal peptide probabilty 0.721) with cleavage site probability 0.513 between residues 25 and 26; signal peptide 218491005913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491005914 ATP binding site [chemical binding]; other site 218491005915 G-X-G motif; other site 218491005916 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218491005917 putative binding surface; other site 218491005918 active site 218491005919 HMMPfam hit to PF01627, DE Hpt domain, score 0.0016 218491005920 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.4e-12 218491005921 2 probable transmembrane helices predicted for ECA1204 by TMHMM2.0 at aa 5-27 and 292-314 218491005922 Signal peptide predicted for ECA1205 by SignalP 2.0 HMM (Signal peptide probabilty 0.765) with cleavage site probability 0.717 between residues 37 and 38; signal peptide 218491005923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491005924 putative substrate translocation pore; other site 218491005925 12 probable transmembrane helices predicted for ECA1205 by TMHMM2.0 at aa 27-46, 56-78, 85-102, 112-134, 147-169, 174-196, 209-231, 246-268, 275-297, 302-324, 337-359 and 369-388 218491005926 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491005927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491005928 putative DNA binding site [nucleotide binding]; other site 218491005929 putative Zn2+ binding site [ion binding]; other site 218491005930 HMMPfam hit to PF01638, DE Transcriptional regulator, score 6.7e-25 218491005931 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 218491005932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491005933 NAD(P) binding site [chemical binding]; other site 218491005934 active site 218491005935 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.6e-38 218491005936 PS00061 Short-chain dehydrogenases/reductases family signature. 218491005937 Signal peptide predicted for ECA1208 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.668 between residues 45 and 46; signal peptide 218491005938 short chain dehydrogenase; Provisional; Region: PRK12937 218491005939 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 218491005940 NADP binding site [chemical binding]; other site 218491005941 homodimer interface [polypeptide binding]; other site 218491005942 active site 218491005943 substrate binding site [chemical binding]; other site 218491005944 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.1e-68 218491005945 PS00061 Short-chain dehydrogenases/reductases family signature. 218491005946 Signal peptide predicted for ECA1209 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.959 between residues 47 and 48; signal peptide 218491005947 short chain dehydrogenase; Provisional; Region: PRK12937 218491005948 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 218491005949 NADP binding site [chemical binding]; other site 218491005950 homodimer interface [polypeptide binding]; other site 218491005951 active site 218491005952 substrate binding site [chemical binding]; other site 218491005953 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 7.8e-74 218491005954 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 218491005955 chorismate binding enzyme; Region: Chorismate_bind; cl10555 218491005956 HMMPfam hit to PF00425, DE chorismate binding enzyme, score 2.1e-82 218491005957 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 218491005958 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 218491005959 dimer interface [polypeptide binding]; other site 218491005960 tetramer interface [polypeptide binding]; other site 218491005961 PYR/PP interface [polypeptide binding]; other site 218491005962 TPP binding site [chemical binding]; other site 218491005963 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 218491005964 TPP-binding site; other site 218491005965 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 0.00076 218491005966 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 218491005967 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 1.9e-06 218491005968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218491005969 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 218491005970 substrate binding site [chemical binding]; other site 218491005971 oxyanion hole (OAH) forming residues; other site 218491005972 trimer interface [polypeptide binding]; other site 218491005973 HMMPfam hit to PF00378, DE Enoyl-CoA hydratase/isomerase family, score 9.7e-71 218491005974 PS00166 Enoyl-CoA hydratase/isomerase signature. 218491005975 O-succinylbenzoate synthase; Provisional; Region: PRK05105 218491005976 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 218491005977 active site 218491005978 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 218491005979 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 218491005980 acyl-activating enzyme (AAE) consensus motif; other site 218491005981 putative AMP binding site [chemical binding]; other site 218491005982 putative active site [active] 218491005983 putative CoA binding site [chemical binding]; other site 218491005984 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.1e-63 218491005985 PS00455 AMP-binding domain signature. 218491005986 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 218491005987 PS00017 ATP/GTP-binding site motif A (P-loop). 218491005988 Signal peptide predicted for ECA1217 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 21 and 22; signal peptide 218491005989 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 218491005990 tyrosine transporter TyrP; Provisional; Region: PRK15132 218491005991 Signal peptide predicted for ECA1218 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.728 between residues 29 and 30; signal peptide 218491005992 aromatic amino acid transport protein; Region: araaP; TIGR00837 218491005993 11 probable transmembrane helices predicted for ECA1218 by TMHMM2.0 at aa 7-29, 33-55, 78-100, 120-142, 149-168, 183-205, 217-236, 273-295, 307-329, 333-355 and 376-398 218491005994 HMMPfam hit to PF03222, DE Tryptophan/tyrosine permease family, score 1.5e-184 218491005995 PS00594 Aromatic amino acids permeases signature. 218491005996 hypothetical protein; Provisional; Region: PRK03673 218491005997 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 218491005998 putative MPT binding site; other site 218491005999 Competence-damaged protein; Region: CinA; cl00666 218491006000 HMMPfam hit to PF00994, DE Probable molybdopterin binding domain, score 1.7e-06 218491006001 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 218491006002 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 218491006003 HMMPfam hit to PF00085, DE Thioredoxin, score 2.1e-15 218491006004 oxidoreductase; Provisional; Region: PRK08017 218491006005 Signal peptide predicted for ECA1221 by SignalP 2.0 HMM (Signal peptide probabilty 0.883) with cleavage site probability 0.829 between residues 19 and 20; signal peptide 218491006006 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 218491006007 NADP binding site [chemical binding]; other site 218491006008 active site 218491006009 steroid binding site; other site 218491006010 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2.6e-43 218491006011 PS00061 Short-chain dehydrogenases/reductases family signature. 218491006012 Signal peptide predicted for ECA1222 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 42 and 43; signal peptide 218491006013 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 218491006014 active site 218491006015 catalytic triad [active] 218491006016 oxyanion hole [active] 218491006017 switch loop; other site 218491006018 HMMPfam hit to PF00657, DE GDSL-like Lipase/Acylhydrolase, score 1.6e-20 218491006019 PS01098 Lipolytic enzymes G-D-S-L family, serine active site. 218491006020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218491006021 ABC transporter; Region: ABC_tran; pfam00005 218491006022 Q-loop/lid; other site 218491006023 ABC transporter signature motif; other site 218491006024 Walker B; other site 218491006025 D-loop; other site 218491006026 H-loop/switch region; other site 218491006027 HMMPfam hit to PF00005, DE ABC transporter, score 4e-33 218491006028 PS00211 ABC transporters family signature. 218491006029 Signal peptide predicted for ECA1224 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.475 between residues 31 and 32; signal peptide 218491006030 FtsX-like permease family; Region: FtsX; pfam02687 218491006031 10 probable transmembrane helices predicted for ECA1224 by TMHMM2.0 at aa 13-35, 243-265, 296-318, 338-360, 381-403, 407-429, 450-472, 681-703, 737-759 and 774-796 218491006032 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006033 HMMPfam hit to PF02687, DE Predicted permease, score 1e-17 218491006034 HMMPfam hit to PF02687, DE Predicted permease, score 1.6e-05 218491006035 hydrogenase 2 small subunit; Provisional; Region: PRK10468 218491006036 Signal peptide predicted for ECA1225 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.670 between residues 37 and 38; signal peptide 218491006037 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 218491006038 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 218491006039 HMMPfam hit to PF01058, DE NADH ubiquinone oxidoreductase, 20 Kd subunit, score 0.0054 218491006040 1 probable transmembrane helix predicted for ECA1225 by TMHMM2.0 at aa 334-356 218491006041 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 218491006042 Signal peptide predicted for ECA1226 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.922 between residues 25 and 26; signal peptide 218491006043 4Fe-4S binding domain; Region: Fer4_6; pfam12837 218491006044 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00017 218491006045 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006046 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 218491006047 10 probable transmembrane helices predicted for ECA1227 by TMHMM2.0 at aa 13-35, 55-77, 89-111, 131-153, 174-196, 211-233, 253-272, 287-304, 316-335 and 355-377 218491006048 HMMPfam hit to PF03916, DE Polysulphide reductase, NrfD, score 0.00016 218491006049 hydrogenase 2 large subunit; Provisional; Region: PRK10467 218491006050 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 218491006051 HMMPfam hit to PF00374, DE Nickel-dependent hydrogenase, score 1.2e-267 218491006052 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 218491006053 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 218491006054 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 218491006055 nickel binding site [ion binding]; other site 218491006056 putative substrate-binding site; other site 218491006057 HMMPfam hit to PF01750, DE Hydrogenase maturation protease, score 9.3e-45 218491006058 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 218491006059 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 218491006060 dimerization interface [polypeptide binding]; other site 218491006061 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 218491006062 ATP binding site [chemical binding]; other site 218491006063 HMMPfam hit to PF02769, DE AIR synthase related protein, C-terminal domain, score 1.6e-32 218491006064 HMMPfam hit to PF00586, DE AIR synthase related protein, N-terminal domain, score 2.3e-48 218491006065 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 218491006066 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 218491006067 HMMPfam hit to PF01924, DE Hydrogenase formation hypA family, score 4.7e-242 218491006068 hydrogenase assembly chaperone; Provisional; Region: PRK10409 218491006069 HMMPfam hit to PF01455, DE HupF/HypC family, score 9.9e-29 218491006070 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 218491006071 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 218491006072 HMMPfam hit to PF01495, DE HypB/UreG nucleotide-binding domain, score 2.3e-75 218491006073 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 218491006074 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 218491006075 HMMPfam hit to PF01155, DE Hydrogenase expression/synthesis hypA family, score 7e-63 218491006076 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 218491006077 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218491006078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491006079 Walker A motif; other site 218491006080 ATP binding site [chemical binding]; other site 218491006081 Walker B motif; other site 218491006082 arginine finger; other site 218491006083 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218491006084 HMMPfam hit to PF01590, DE GAF domain, score 1.9e-16 218491006085 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 5.6e-141 218491006086 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491006087 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491006088 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491006089 HMMPfam hit to PF02954, DE Bacterial regulatory protein, Fis family, score 7.8e-08 218491006090 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 218491006091 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 218491006092 nickel binding site [ion binding]; other site 218491006093 HMMPfam hit to PF01750, DE Hydrogenase maturation protease, score 7.8e-24 218491006094 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 218491006095 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 218491006096 HMMPfam hit to PF01058, DE NADH ubiquinone oxidoreductase, 20 Kd subunit, score 4.7e-45 218491006097 hydrogenase 4 subunit H; Validated; Region: PRK08222 218491006098 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491006099 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 2.6e-06 218491006100 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006101 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 1.1e-05 218491006102 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006103 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 218491006104 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 218491006105 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 218491006106 HMMPfam hit to PF00346, DE Respiratory-chain NADH dehydrogenase, 49 Kd subunit, score 1.1e-11 218491006107 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 218491006108 HMMPfam hit to PF00329, DE Respiratory-chain NADH dehydrogenase, 30 Kd subunit, score 1.1e-24 218491006109 hydrogenase 4 subunit F; Validated; Region: PRK06458 218491006110 Signal peptide predicted for ECA1242 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.366 between residues 26 and 27; signal peptide 218491006111 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218491006112 12 probable transmembrane helices predicted for ECA1242 by TMHMM2.0 at aa 4-26, 38-60, 75-97, 118-140, 164-186, 220-242, 252-274, 286-308, 323-345, 376-398, 418-437 and 457-479 218491006113 HMMPfam hit to PF00361, DE NADH-Ubiquinone/plastoquinone (complex I), various chains, score 3.7e-53 218491006114 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 218491006115 5 probable transmembrane helices predicted for ECA1243 by TMHMM2.0 at aa 5-24, 31-48, 58-80, 92-114 and 127-149 218491006116 Signal peptide predicted for ECA1244 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.426 between residues 34 and 35; signal peptide 218491006117 hydrogenase 4 subunit D; Validated; Region: PRK06525 218491006118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218491006119 12 probable transmembrane helices predicted for ECA1244 by TMHMM2.0 at aa 10-29, 36-58, 87-109, 122-144, 175-197, 204-226, 276-298, 305-327, 337-359, 379-401, 416-438 and 465-484 218491006120 HMMPfam hit to PF00361, DE NADH-Ubiquinone/plastoquinone (complex I), various chains, score 6.3e-54 218491006121 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491006122 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 218491006123 NADH dehydrogenase; Region: NADHdh; cl00469 218491006124 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00146, DE NADH dehydrogenase, score 1.4e-43 218491006125 8 probable transmembrane helices predicted for ECA1245 by TMHMM2.0 at aa 10-32, 71-93, 98-120, 140-162, 177-196, 225-247, 257-279 and 292-314 218491006126 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 218491006127 hydrogenase 4 subunit B; Validated; Region: PRK06521 218491006128 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218491006129 16 probable transmembrane helices predicted for ECA1246 by TMHMM2.0 at aa 6-25, 32-54, 79-101, 108-130, 134-153, 165-187, 209-231, 244-266, 271-293, 306-325, 340-362, 382-404, 424-446, 476-498, 528-550 and 653-670 218491006130 HMMPfam hit to PF00361, DE NADH-Ubiquinone/plastoquinone (complex I), various chains, score 2.6e-52 218491006131 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 218491006132 4Fe-4S binding domain; Region: Fer4; pfam00037 218491006133 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 1.2e-07 218491006134 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006135 1 probable transmembrane helix predicted for ECA1248 by TMHMM2.0 at aa 10-32 218491006136 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 218491006137 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.019 218491006138 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 2.8e-05 218491006139 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006140 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.02 218491006141 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 218491006142 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 218491006143 [4Fe-4S] binding site [ion binding]; other site 218491006144 molybdopterin cofactor binding site; other site 218491006145 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 218491006146 molybdopterin cofactor binding site; other site 218491006147 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 2.9e-193 218491006148 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 218491006149 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 5.8e-32 218491006150 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 218491006151 Acylphosphatase; Region: Acylphosphatase; pfam00708 218491006152 HypF finger; Region: zf-HYPF; pfam07503 218491006153 HypF finger; Region: zf-HYPF; pfam07503 218491006154 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 218491006155 HMMPfam hit to PF00708, DE Acylphosphatase, score 6.9e-05 218491006156 PS00150 Acylphosphatase signature 1. 218491006157 HMMPfam hit to PF01300, DE yrdC domain, score 4.9e-64 218491006158 Signal peptide predicted for ECA1252 by SignalP 2.0 HMM (Signal peptide probabilty 0.741) with cleavage site probability 0.485 between residues 22 and 23; signal peptide 218491006159 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 218491006160 7 probable transmembrane helices predicted for ECA1252 by TMHMM2.0 at aa 15-34, 80-102, 117-139, 185-207, 217-239, 260-282 and 307-329 218491006161 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006162 HMMPfam hit to PF03824, DE High-affinity nickel-transport protein, score 4.4e-162 218491006163 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 218491006164 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 218491006165 active site 218491006166 substrate binding site [chemical binding]; other site 218491006167 cosubstrate binding site; other site 218491006168 catalytic site [active] 218491006169 HMMPfam hit to PF00551, DE Formyl transferase, score 2.1e-79 218491006170 PS00373 Phosphoribosylglycinamide formyltransferase active site. 218491006171 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 218491006172 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 218491006173 dimerization interface [polypeptide binding]; other site 218491006174 putative ATP binding site [chemical binding]; other site 218491006175 HMMPfam hit to PF02769, DE AIR synthase related protein, C-terminal domain, score 5.5e-51 218491006176 HMMPfam hit to PF00586, DE AIR synthase related protein, N-terminal domain, score 6.9e-73 218491006177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491006178 active site 218491006179 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 9.4e-16 218491006180 uracil transporter; Provisional; Region: PRK10720 218491006181 HMMPfam hit to PF00860, DE Permease family, score 1.5e-134 218491006182 12 probable transmembrane helices predicted for ECA1256 by TMHMM2.0 at aa 20-39, 44-61, 68-85, 89-108, 115-137, 157-176, 183-205, 225-247, 304-326, 331-353, 365-387 and 392-411 218491006183 PS01116 Xanthine/uracil permeases family signature. 218491006184 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 218491006185 DNA replication initiation factor; Provisional; Region: PRK08084 218491006186 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 218491006187 ArsC family; Region: ArsC; pfam03960 218491006188 catalytic residues [active] 218491006189 HMMPfam hit to PF03960, DE ArsC family, score 7.4e-37 218491006190 Signal peptide predicted for ECA1259 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 27 and 28; signal peptide 218491006191 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 218491006192 Peptidase family M48; Region: Peptidase_M48; pfam01435 218491006193 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 218491006194 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 218491006195 catalytic triad [active] 218491006196 HMMPfam hit to PF00578, DE AhpC/TSA family, score 1e-59 218491006197 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 218491006198 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 218491006199 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 218491006200 HMMPfam hit to PF01842, DE ACT domain, score 1.8 218491006201 HMMPfam hit to PF01842, DE ACT domain, score 5.9 218491006202 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 218491006203 dihydrodipicolinate synthase; Region: dapA; TIGR00674 218491006204 dimer interface [polypeptide binding]; other site 218491006205 active site 218491006206 catalytic residue [active] 218491006207 HMMPfam hit to PF00701, DE Dihydrodipicolinate synthetase family, score 4.3e-157 218491006208 PS00665 Dihydrodipicolinate synthetase signature 1. 218491006209 PS00666 Dihydrodipicolinate synthetase signature 2. 218491006210 lipoprotein; Provisional; Region: PRK11679 218491006211 Signal peptide predicted for ECA1263 by SignalP 2.0 HMM (Signal peptide probabilty 0.799) with cleavage site probability 0.316 between residues 26 and 27; signal peptide 218491006212 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 218491006213 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006214 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 218491006215 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 218491006216 ATP binding site [chemical binding]; other site 218491006217 active site 218491006218 substrate binding site [chemical binding]; other site 218491006219 HMMPfam hit to PF01259, DE SAICAR synthetase, score 5.6e-116 218491006220 PS01057 SAICAR synthetase signature 1. 218491006221 PS01058 SAICAR synthetase signature 2. 218491006222 Predicted membrane protein [Function unknown]; Region: COG2707 218491006223 4 probable transmembrane helices predicted for ECA1265 by TMHMM2.0 at aa 7-36, 51-73, 80-102 and 126-148 218491006224 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 218491006225 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 218491006226 Helicase; Region: Helicase_RecD; pfam05127 218491006227 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 218491006228 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 218491006229 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006230 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 0.00081 218491006231 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218491006232 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218491006233 catalytic residues [active] 218491006234 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006235 HMMPfam hit to PF00085, DE Thioredoxin, score 2.6e-28 218491006236 protease TldD; Provisional; Region: tldD; PRK10735 218491006237 HMMPfam hit to PF01523, DE modulator of DNA gyrase, score 3.3e-74 218491006238 peptidase PmbA; Provisional; Region: PRK11040 218491006239 HMMPfam hit to PF01523, DE modulator of DNA gyrase, score 2.5e-41 218491006240 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218491006241 TolR protein; Region: tolR; TIGR02801 218491006242 HMMPfam hit to PF02472, DE Biopolymer transport protein ExbD/TolR, score 3.2e-11 218491006243 1 probable transmembrane helix predicted for ECA1270 by TMHMM2.0 at aa 20-42 218491006244 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 218491006245 HMMPfam hit to PF01618, DE MotA/TolQ/ExbB proton channel family, score 1.6e-35 218491006246 3 probable transmembrane helices predicted for ECA1271 by TMHMM2.0 at aa 15-37, 127-149 and 174-196 218491006247 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 218491006248 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 218491006249 HMMPfam hit to PF03544, DE Gram-negative bacterial tonB protein, score 5.4e-06 218491006250 1 probable transmembrane helix predicted for ECA1272 by TMHMM2.0 at aa 47-69 218491006251 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 218491006252 FecR protein; Region: FecR; pfam04773 218491006253 RNA polymerase sigma factor; Provisional; Region: PRK12525 218491006254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491006255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491006256 DNA binding residues [nucleotide binding] 218491006257 Predicted helix-turn-helix motif with score 1630.000, SD 4.74 at aa 136-157, sequence MTYADIAVQLDVSASMVRKYIA 218491006258 Signal peptide predicted for ECA1275 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 44 and 45; signal peptide 218491006259 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491006260 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491006261 N-terminal plug; other site 218491006262 ligand-binding site [chemical binding]; other site 218491006263 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 1.8e-09 218491006264 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 218491006265 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 218491006266 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 218491006267 4 probable transmembrane helices predicted for ECA1276 by TMHMM2.0 at aa 27-49, 69-91, 148-170 and 185-207 218491006268 HMMPfam hit to PF00005, DE ABC transporter, score 5.2e-30 218491006269 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006270 PS00211 ABC transporters family signature. 218491006271 Predicted ATPase [General function prediction only]; Region: COG3910 218491006272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 218491006273 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 218491006274 putative hydrolase; Provisional; Region: PRK11460 218491006275 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 218491006276 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02230, DE Phospholipase/Carboxylesterase, score 4.9e-33 218491006277 Signal peptide predicted for ECA1281 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.493 between residues 32 and 33; signal peptide 218491006278 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 218491006279 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218491006280 dimer interface [polypeptide binding]; other site 218491006281 ligand binding site [chemical binding]; other site 218491006282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491006283 dimerization interface [polypeptide binding]; other site 218491006284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491006285 dimer interface [polypeptide binding]; other site 218491006286 putative CheW interface [polypeptide binding]; other site 218491006287 3 probable transmembrane helices predicted for ECA1281 by TMHMM2.0 at aa 7-29, 49-71 and 191-213 218491006288 HMMPfam hit to PF00672, DE HAMP domain, score 3.4e-12 218491006289 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 3.7e-116 218491006290 putative acyltransferase; Provisional; Region: PRK05790 218491006291 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218491006292 dimer interface [polypeptide binding]; other site 218491006293 active site 218491006294 HMMPfam hit to PF02803, DE Thiolase, C-terminal domain, score 2.4e-74 218491006295 PS00099 Thiolases active site. 218491006296 PS00737 Thiolases signature 2. 218491006297 HMMPfam hit to PF00108, DE Thiolase, N-terminal domain, score 4.4e-130 218491006298 PS00098 Thiolases acyl-enzyme intermediate signature. 218491006299 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 218491006300 HMMPfam hit to PF01144, DE Coenzyme A transferase, score 2.6e-60 218491006301 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006302 PS01274 CoA transferases signature 2. 218491006303 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 218491006304 HMMPfam hit to PF01144, DE Coenzyme A transferase, score 3.8e-93 218491006305 PS01273 CoA transferases signature 1. 218491006306 1 probable transmembrane helix predicted for ECA1284 by TMHMM2.0 at aa 13-30 218491006307 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 218491006308 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 218491006309 Signal peptide predicted for ECA1287 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.767 between residues 38 and 39; signal peptide 218491006310 Citrate transporter; Region: CitMHS; pfam03600 218491006311 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03600, DE Citrate transporter, score 4.7e-166 218491006312 14 probable transmembrane helices predicted for ECA1287 by TMHMM2.0 at aa 4-18, 25-42, 57-79, 86-108, 112-129, 138-157, 172-194, 239-256, 261-279, 292-311, 331-350, 355-377, 387-409 and 416-438 218491006313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491006314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491006315 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 218491006316 putative dimerization interface [polypeptide binding]; other site 218491006317 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.8e-22 218491006318 Predicted helix-turn-helix motif with score 1246.000, SD 3.43 at aa 18-39, sequence DNFTRAAQKINLSQPAFSSLIA 218491006319 PS00044 Bacterial regulatory proteins, lysR family signature. 218491006320 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.1e-45 218491006321 1 probable transmembrane helix predicted for ECA1288 by TMHMM2.0 at aa 224-246 218491006322 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 218491006323 1 probable transmembrane helix predicted for ECA1289 by TMHMM2.0 at aa 4-23 218491006324 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 218491006325 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 218491006326 HMMPfam hit to PF02557, DE D-alanyl-D-alanine carboxypeptidase, score 1.2e-09 218491006327 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 218491006328 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 218491006329 metal binding site [ion binding]; metal-binding site 218491006330 dimer interface [polypeptide binding]; other site 218491006331 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 1.9e-85 218491006332 PS00256 Adipokinetic hormone family signature. 218491006333 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 218491006334 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218491006335 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006336 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 218491006337 ArsC family; Region: ArsC; pfam03960 218491006338 putative catalytic residues [active] 218491006339 HMMPfam hit to PF03960, DE ArsC family, score 1e-28 218491006340 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 218491006341 aspartate racemase; Region: asp_race; TIGR00035 218491006342 HMMPfam hit to PF01177, DE Asp/Glu/Hydantoin racemase, score 5.7e-37 218491006343 PS00924 Aspartate and glutamate racemases signature 2. 218491006344 PS00923 Aspartate and glutamate racemases signature 1. 218491006345 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218491006346 DNA-binding site [nucleotide binding]; DNA binding site 218491006347 RNA-binding motif; other site 218491006348 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00313, DE 'Cold-shock' DNA-binding domain, score 2.3e-43 218491006349 PS00352 'Cold-shock' DNA-binding domain signature. 218491006350 chromosome condensation membrane protein; Provisional; Region: PRK14196 218491006351 Signal peptide predicted for ECA1295 by SignalP 2.0 HMM (Signal peptide probabilty 0.617) with cleavage site probability 0.425 between residues 18 and 19; signal peptide 218491006352 4 probable transmembrane helices predicted for ECA1295 by TMHMM2.0 at aa 5-23, 33-55, 67-89 and 99-121 218491006353 HMMPfam hit to PF02537, DE CrcB-like protein, score 1.9e-37 218491006354 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 218491006355 HMMPfam hit to PF02416, DE mttA/Hcf106 family, score 1.7e-07 218491006356 1 probable transmembrane helix predicted for ECA1296 by TMHMM2.0 at aa 4-21 218491006357 lipoyl synthase; Provisional; Region: PRK05481 218491006358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491006359 FeS/SAM binding site; other site 218491006360 HMMPfam hit to PF02546, , score 1.9e-199 218491006361 lipoate-protein ligase B; Provisional; Region: PRK14342 218491006362 HMMPfam hit to PF03099, DE Biotin/lipoate A/B protein ligase family, score 2.7e-32 218491006363 PS01313 Lipoate-protein ligase B signature. 218491006364 hypothetical protein; Provisional; Region: PRK04998 218491006365 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 218491006366 Signal peptide predicted for ECA1300 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.927 between residues 29 and 30; signal peptide 218491006367 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 218491006368 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 218491006369 HMMPfam hit to PF00768, DE D-alanyl-D-alanine carboxypeptidase, score 5.3e-150 218491006370 rare lipoprotein A; Provisional; Region: PRK10672 218491006371 Signal peptide predicted for ECA1301 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.654 between residues 24 and 25; signal peptide 218491006372 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 218491006373 Sporulation related domain; Region: SPOR; pfam05036 218491006374 HMMPfam hit to PF03330, DE Rare lipoprotein A (RlpA) family, score 2.5e-48 218491006375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006376 cell wall shape-determining protein; Provisional; Region: PRK10794 218491006377 HMMPfam hit to PF01098, DE Cell cycle protein, score 5.5e-172 218491006378 9 probable transmembrane helices predicted for ECA1302 by TMHMM2.0 at aa 15-37, 50-68, 73-95, 136-155, 160-179, 181-203, 272-294, 306-328 and 338-360 218491006379 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 218491006380 penicillin-binding protein 2; Provisional; Region: PRK10795 218491006381 Signal peptide predicted for ECA1303 by SignalP 2.0 HMM (Signal peptide probabilty 0.653) with cleavage site probability 0.552 between residues 38 and 39; signal peptide 218491006382 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218491006383 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218491006384 HMMPfam hit to PF00905, DE Penicillin binding protein transpeptidase domain, score 4.9e-107 218491006385 HMMPfam hit to PF03717, DE Penicillin-binding Protein dimerisation domain, score 1.8e-60 218491006386 1 probable transmembrane helix predicted for ECA1303 by TMHMM2.0 at aa 21-43 218491006387 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 218491006388 HMMPfam hit to PF02590, DE Uncharacterized ACR, COG1576, score 2.8e-89 218491006389 ribosome-associated protein; Provisional; Region: PRK11538 218491006390 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02410, DE Domain of unknown function DUF143, score 6.6e-49 218491006391 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 218491006392 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 218491006393 active site 218491006394 (T/H)XGH motif; other site 218491006395 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 218491006396 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 218491006397 Signal peptide predicted for ECA1308 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.635 between residues 32 and 33; signal peptide 218491006398 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 218491006399 1 probable transmembrane helix predicted for ECA1308 by TMHMM2.0 at aa 5-27 218491006400 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006401 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 218491006402 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 218491006403 HIGH motif; other site 218491006404 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 218491006405 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218491006406 active site 218491006407 KMSKS motif; other site 218491006408 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 218491006409 tRNA binding surface [nucleotide binding]; other site 218491006410 HMMPfam hit to PF00133, DE tRNA synthetases class I (I, L, M and V), score 1.9e-275 218491006411 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491006412 hypothetical protein; Provisional; Region: PRK11032 218491006413 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491006414 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491006415 Walker A/P-loop; other site 218491006416 ATP binding site [chemical binding]; other site 218491006417 Q-loop/lid; other site 218491006418 ABC transporter signature motif; other site 218491006419 Walker B; other site 218491006420 D-loop; other site 218491006421 H-loop/switch region; other site 218491006422 HMMPfam hit to PF00005, DE ABC transporter, score 4e-65 218491006423 PS00211 ABC transporters family signature. 218491006424 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006425 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491006427 dimer interface [polypeptide binding]; other site 218491006428 conserved gate region; other site 218491006429 putative PBP binding loops; other site 218491006430 ABC-ATPase subunit interface; other site 218491006431 5 probable transmembrane helices predicted for ECA1312 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 218491006432 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9e-21 218491006433 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491006435 dimer interface [polypeptide binding]; other site 218491006436 conserved gate region; other site 218491006437 putative PBP binding loops; other site 218491006438 ABC-ATPase subunit interface; other site 218491006439 4 probable transmembrane helices predicted for ECA1313 by TMHMM2.0 at aa 31-53, 66-88, 108-127 and 211-233 218491006440 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.4e-17 218491006441 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 218491006442 Signal peptide predicted for ECA1314 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.964 between residues 22 and 23; signal peptide 218491006443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491006444 substrate binding pocket [chemical binding]; other site 218491006445 membrane-bound complex binding site; other site 218491006446 hinge residues; other site 218491006447 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 9.1e-56 218491006448 Signal peptide predicted for ECA1315 by SignalP 2.0 HMM (Signal peptide probabilty 0.898) with cleavage site probability 0.330 between residues 46 and 47; signal peptide 218491006449 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 218491006450 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 218491006451 putative active site [active] 218491006452 catalytic triad [active] 218491006453 putative dimer interface [polypeptide binding]; other site 218491006454 7 probable transmembrane helices predicted for ECA1315 by TMHMM2.0 at aa 15-37, 58-80, 90-112, 121-143, 163-185, 192-214 and 487-506 218491006455 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 218491006456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218491006457 Transporter associated domain; Region: CorC_HlyC; smart01091 218491006458 HMMPfam hit to PF03471, DE Transporter associated domain, score 6.8e-32 218491006459 HMMPfam hit to PF00571, DE CBS domain, score 6.8e-08 218491006460 HMMPfam hit to PF00571, DE CBS domain, score 2.7e-10 218491006461 metal-binding heat shock protein; Provisional; Region: PRK00016 218491006462 HMMPfam hit to PF02130, DE Uncharacterized protein family UPF0054, score 8.9e-51 218491006463 PS01306 Uncharacterized protein family UPF0054 signature. 218491006464 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 218491006465 PhoH-like protein; Region: PhoH; pfam02562 218491006466 HMMPfam hit to PF02562, DE PhoH-like protein, score 1.4e-217 218491006467 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006468 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 218491006469 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218491006470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491006471 FeS/SAM binding site; other site 218491006472 TRAM domain; Region: TRAM; pfam01938 218491006473 HMMPfam hit to PF01938, DE TRAM domain, score 1.6e-20 218491006474 PS01278 Uncharacterized protein family UPF0004 signature. 218491006475 HMMPfam hit to PF00919, DE Uncharacterized protein family UPF0004, score 1.4e-47 218491006476 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 218491006477 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 218491006478 HMMPfam hit to PF01360, DE Monooxygenase, score 1.2e-34 218491006479 1 probable transmembrane helix predicted for ECA1321 by TMHMM2.0 at aa 55-77 218491006480 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 218491006481 1 probable transmembrane helix predicted for ECA1322 by TMHMM2.0 at aa 28-50 218491006482 asparagine synthetase B; Provisional; Region: asnB; PRK09431 218491006483 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 218491006484 active site 218491006485 dimer interface [polypeptide binding]; other site 218491006486 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 218491006487 Ligand Binding Site [chemical binding]; other site 218491006488 Molecular Tunnel; other site 218491006489 HMMPfam hit to PF00733, DE Asparagine synthase, score 1.9e-198 218491006490 HMMPfam hit to PF00310, DE Glutamine amidotransferases class-II, score 7.2e-61 218491006491 PS00443 Glutamine amidotransferases class-II active site. 218491006492 MarR family; Region: MarR; pfam01047 218491006493 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218491006494 ROK family; Region: ROK; pfam00480 218491006495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 218491006496 HMMPfam hit to PF00480, DE ROK family, score 2.4e-58 218491006497 PS01125 ROK family signature. 218491006498 Predicted helix-turn-helix motif with score 1021.000, SD 2.66 at aa 49-70, sequence ISRIQIAEQSQLAPASVTKITR 218491006499 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 218491006500 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 218491006501 active site 218491006502 dimer interface [polypeptide binding]; other site 218491006503 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02612, , score 5.7e-94 218491006504 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 218491006505 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 218491006506 active site 218491006507 trimer interface [polypeptide binding]; other site 218491006508 allosteric site; other site 218491006509 active site lid [active] 218491006510 hexamer (dimer of trimers) interface [polypeptide binding]; other site 218491006511 HMMPfam hit to PF01182, DE Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase, score 6.5e-158 218491006512 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 218491006513 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491006514 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 218491006515 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491006516 active site turn [active] 218491006517 phosphorylation site [posttranslational modification] 218491006518 10 probable transmembrane helices predicted for ECA1327 by TMHMM2.0 at aa 30-52, 67-89, 101-123, 138-155, 176-198, 208-227, 275-294, 304-321, 334-356 and 376-398 218491006519 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 2.8e-111 218491006520 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 2.1e-15 218491006521 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491006522 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 218491006523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218491006524 active site 218491006525 HIGH motif; other site 218491006526 nucleotide binding site [chemical binding]; other site 218491006527 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 218491006528 KMSKS motif; other site 218491006529 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 218491006530 HMMPfam hit to PF00749, DE tRNA synthetases class I (E and Q), catalytic domain, score 2.9e-177 218491006531 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491006532 HMMPfam hit to PF03950, DE tRNA synthetases class I (E and Q), anti-codon binding domain, score 5.5e-107 218491006533 ferric uptake regulator; Provisional; Region: fur; PRK09462 218491006534 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 218491006535 metal binding site 2 [ion binding]; metal-binding site 218491006536 putative DNA binding helix; other site 218491006537 metal binding site 1 [ion binding]; metal-binding site 218491006538 dimer interface [polypeptide binding]; other site 218491006539 structural Zn2+ binding site [ion binding]; other site 218491006540 HMMPfam hit to PF01475, DE Ferric uptake regulator family, score 1.5e-70 218491006541 flavodoxin FldA; Validated; Region: PRK09267 218491006542 HMMPfam hit to PF00258, DE Flavodoxin, score 8.4e-44 218491006543 PS00201 Flavodoxin signature. 218491006544 Signal peptide predicted for ECA1332 by SignalP 2.0 HMM (Signal peptide probabilty 0.944) with cleavage site probability 0.663 between residues 39 and 40; signal peptide 218491006545 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 218491006546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491006547 dimer interface [polypeptide binding]; other site 218491006548 putative CheW interface [polypeptide binding]; other site 218491006549 1 probable transmembrane helix predicted for ECA1332 by TMHMM2.0 at aa 13-35 218491006550 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 3.1e-112 218491006551 PS00538 Bacterial chemotaxis sensory transducers signature. 218491006552 LexA regulated protein; Provisional; Region: PRK11675 218491006553 HMMPfam hit to PF01402, DE Ribbon-helix-helix protein, copG family, score 6.9e-05 218491006554 acyl-CoA esterase; Provisional; Region: PRK10673 218491006555 PGAP1-like protein; Region: PGAP1; pfam07819 218491006556 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 1.3e-18 218491006557 replication initiation regulator SeqA; Provisional; Region: PRK11187 218491006558 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03925, DE SeqA protein, score 3.6e-108 218491006559 phosphoglucomutase; Validated; Region: PRK07564 218491006560 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 218491006561 active site 218491006562 substrate binding site [chemical binding]; other site 218491006563 metal binding site [ion binding]; metal-binding site 218491006564 HMMPfam hit to PF02878, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 9.9e-40 218491006565 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218491006566 HMMPfam hit to PF02879, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 1.9e-18 218491006567 HMMPfam hit to PF02880, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 1.1e-28 218491006568 HMMPfam hit to PF00408, DE Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 1.8e-11 218491006569 Predicted membrane protein [Function unknown]; Region: COG2510 218491006570 Signal peptide predicted for ECA1337 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.376 between residues 22 and 23; signal peptide 218491006571 5 probable transmembrane helices predicted for ECA1337 by TMHMM2.0 at aa 5-27, 37-59, 68-90, 95-117 and 122-141 218491006572 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 2.7e-19 218491006573 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 218491006574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491006575 active site 218491006576 phosphorylation site [posttranslational modification] 218491006577 intermolecular recognition site; other site 218491006578 dimerization interface [polypeptide binding]; other site 218491006579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491006580 DNA binding site [nucleotide binding] 218491006581 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 1.2e-26 218491006582 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.1e-39 218491006583 sensor protein KdpD; Provisional; Region: PRK10490 218491006584 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 218491006585 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 218491006586 Ligand Binding Site [chemical binding]; other site 218491006587 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 218491006588 GAF domain; Region: GAF_3; pfam13492 218491006589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491006590 dimer interface [polypeptide binding]; other site 218491006591 phosphorylation site [posttranslational modification] 218491006592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491006593 ATP binding site [chemical binding]; other site 218491006594 Mg2+ binding site [ion binding]; other site 218491006595 G-X-G motif; other site 218491006596 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 3.5e-33 218491006597 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 2.7e-13 218491006598 4 probable transmembrane helices predicted for ECA1339 by TMHMM2.0 at aa 402-421, 425-447, 454-476 and 480-502 218491006599 HMMPfam hit to PF02702, DE Osmosensitive K+ channel His kinase sensor domain, score 1.7e-216 218491006600 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006601 Signal peptide predicted for ECA1340 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.607 between residues 30 and 31; signal peptide 218491006602 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 218491006603 HMMPfam hit to PF02669, DE K+-transporting ATPase, c chain, score 1.2e-80 218491006604 1 probable transmembrane helix predicted for ECA1340 by TMHMM2.0 at aa 7-29 218491006605 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 218491006606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218491006607 7 probable transmembrane helices predicted for ECA1341 by TMHMM2.0 at aa 59-81, 86-108, 245-267, 282-304, 609-631, 651-673 and 686-708 218491006608 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 5.8e-32 218491006609 PS00063 Aldo/keto reductase family active site signature. 218491006610 PS00154 E1-E2 ATPases phosphorylation site. 218491006611 HMMPfam hit to PF00122, DE E1-E2 ATPase, score 1.1e-55 218491006612 Signal peptide predicted for ECA1342 by SignalP 2.0 HMM (Signal peptide probabilty 0.855) with cleavage site probability 0.786 between residues 20 and 21; signal peptide 218491006613 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 218491006614 HMMPfam hit to PF03814, DE Potassium-transporting ATPase A subunit, score 0 218491006615 10 probable transmembrane helices predicted for ECA1342 by TMHMM2.0 at aa 5-27, 62-84, 130-152, 173-195, 253-275, 282-299, 373-395, 416-438, 483-505 and 526-548 218491006616 1 probable transmembrane helix predicted for ECA1343 by TMHMM2.0 at aa 43-65 218491006617 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 218491006618 1 probable transmembrane helix predicted for ECA1344 by TMHMM2.0 at aa 13-32 218491006619 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 218491006620 Signal peptide predicted for ECA1345 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.952 between residues 48 and 49; signal peptide 218491006621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491006622 dimer interface [polypeptide binding]; other site 218491006623 conserved gate region; other site 218491006624 putative PBP binding loops; other site 218491006625 ABC-ATPase subunit interface; other site 218491006626 12 probable transmembrane helices predicted for ECA1345 by TMHMM2.0 at aa 5-27, 66-88, 95-117, 137-159, 185-207, 246-268, 289-311, 354-376, 389-411, 421-443, 464-486 and 526-548 218491006627 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4e-06 218491006628 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.3e-07 218491006629 Signal peptide predicted for ECA1346 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 30 and 31; signal peptide 218491006630 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 218491006631 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 218491006632 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 8.3e-11 218491006633 PS00177 DNA topoisomerase II signature. 218491006634 1 probable transmembrane helix predicted for ECA1346 by TMHMM2.0 at aa 13-35 218491006635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491006636 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 218491006637 Walker A/P-loop; other site 218491006638 ATP binding site [chemical binding]; other site 218491006639 Q-loop/lid; other site 218491006640 ABC transporter signature motif; other site 218491006641 Walker B; other site 218491006642 D-loop; other site 218491006643 H-loop/switch region; other site 218491006644 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-60 218491006645 PS00211 ABC transporters family signature. 218491006646 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006647 Protein of unknown function (DUF523); Region: DUF523; pfam04463 218491006648 Uncharacterized conserved protein [Function unknown]; Region: COG3272 218491006649 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 218491006650 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491006651 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 218491006652 DNA photolyase; Region: DNA_photolyase; pfam00875 218491006653 HMMPfam hit to PF00875, DE DNA photolyase, score 9.2e-48 218491006654 HMMPfam hit to PF03441, DE FAD binding domain of DNA photolyase, score 8.3e-137 218491006655 PS00691 DNA photolyases class 1 signature 2. 218491006656 Uncharacterized conserved protein [Function unknown]; Region: COG0327 218491006657 metal-binding protein; Provisional; Region: PRK10799 218491006658 HMMPfam hit to PF01784, DE NIF3 (NGG1p interacting factor 3), score 4.9e-96 218491006659 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 218491006660 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 218491006661 HMMPfam hit to PF02682, DE Allophanate hydrolase subunit 1, score 2.2e-111 218491006662 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 218491006663 HMMPfam hit to PF02626, DE Allophanate hydrolase subunit 2, score 6.3e-131 218491006664 LamB/YcsF family protein; Provisional; Region: PRK05406 218491006665 HMMPfam hit to PF03746, DE LamB/YcsF family, score 1.6e-121 218491006666 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 218491006667 putative substrate binding pocket [chemical binding]; other site 218491006668 AC domain interface; other site 218491006669 catalytic triad [active] 218491006670 AB domain interface; other site 218491006671 interchain disulfide; other site 218491006672 HMMPfam hit to PF01470, DE Pyroglutamyl peptidase, score 3e-102 218491006673 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 218491006674 PS01334 Pyrrolidone-carboxylate peptidase cysteine active site. 218491006675 endonuclease VIII; Provisional; Region: PRK10445 218491006676 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 218491006677 DNA binding site [nucleotide binding] 218491006678 catalytic residue [active] 218491006679 H2TH interface [polypeptide binding]; other site 218491006680 putative catalytic residues [active] 218491006681 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 218491006682 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218491006683 HMMPfam hit to PF01149, DE Formamidopyrimidine-DNA glycosylase, score 1.4e-84 218491006684 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 218491006685 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 218491006686 dimer interface [polypeptide binding]; other site 218491006687 active site 218491006688 citrylCoA binding site [chemical binding]; other site 218491006689 NADH binding [chemical binding]; other site 218491006690 cationic pore residues; other site 218491006691 oxalacetate/citrate binding site [chemical binding]; other site 218491006692 coenzyme A binding site [chemical binding]; other site 218491006693 catalytic triad [active] 218491006694 HMMPfam hit to PF00285, DE Citrate synthase, score 6.5e-230 218491006695 PS00480 Citrate synthase signature. 218491006696 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 218491006697 Iron-sulfur protein interface; other site 218491006698 proximal quinone binding site [chemical binding]; other site 218491006699 SdhD (CybS) interface [polypeptide binding]; other site 218491006700 proximal heme binding site [chemical binding]; other site 218491006701 HMMPfam hit to PF01127, DE Succinate dehydrogenase cytochrome b subunit, score 1.7e-42 218491006702 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 218491006703 3 probable transmembrane helices predicted for ECA1357 by TMHMM2.0 at aa 27-49, 69-88 and 109-128 218491006704 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 218491006705 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 218491006706 SdhC subunit interface [polypeptide binding]; other site 218491006707 proximal heme binding site [chemical binding]; other site 218491006708 cardiolipin binding site; other site 218491006709 Iron-sulfur protein interface; other site 218491006710 proximal quinone binding site [chemical binding]; other site 218491006711 3 probable transmembrane helices predicted for ECA1358 by TMHMM2.0 at aa 16-38, 48-70 and 91-113 218491006712 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 218491006713 L-aspartate oxidase; Provisional; Region: PRK06175 218491006714 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218491006715 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006716 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 218491006717 HMMPfam hit to PF00890, DE FAD binding domain, score 1.6e-222 218491006718 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02910, DE Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain, score 6.6e-67 218491006719 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 218491006720 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 218491006721 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 0.015 218491006722 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006723 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 218491006724 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 218491006725 TPP-binding site [chemical binding]; other site 218491006726 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 218491006727 dimer interface [polypeptide binding]; other site 218491006728 PYR/PP interface [polypeptide binding]; other site 218491006729 TPP binding site [chemical binding]; other site 218491006730 HMMPfam hit to PF00676, DE Dehydrogenase E1 component, score 7e-26 218491006731 HMMPfam hit to PF02779, DE Transketolase, pyridine binding domain, score 2.9e-75 218491006732 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 218491006733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218491006734 E3 interaction surface; other site 218491006735 lipoyl attachment site [posttranslational modification]; other site 218491006736 e3 binding domain; Region: E3_binding; pfam02817 218491006737 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218491006738 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 3.4e-21 218491006739 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218491006740 HMMPfam hit to PF02817, DE e3 binding domain, score 4.7e-15 218491006741 HMMPfam hit to PF00198, DE 2-oxoacid dehydrogenases acyltransferase (catalytic domain), score 8.9e-140 218491006742 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 218491006743 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 218491006744 CoA-ligase; Region: Ligase_CoA; pfam00549 218491006745 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006746 HMMPfam hit to PF02222, DE ATP-grasp domain, score 2.8e-56 218491006747 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00549, DE CoA-ligase, score 1.2e-77 218491006748 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 218491006749 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 218491006750 CoA binding domain; Region: CoA_binding; smart00881 218491006751 CoA-ligase; Region: Ligase_CoA; pfam00549 218491006752 HMMPfam hit to PF02629, DE CoA binding domain, score 2.5e-69 218491006753 HMMPfam hit to PF00549, DE CoA-ligase, score 1.3e-66 218491006754 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 218491006755 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 218491006756 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 218491006757 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 218491006758 HMMPfam hit to PF01654, DE Bacterial Cytochrome Ubiquinol Oxidase, score 0 218491006759 9 probable transmembrane helices predicted for ECA1365 by TMHMM2.0 at aa 50-72, 84-106, 126-148, 160-182, 215-237, 249-268, 420-442, 455-474 and 496-518 218491006760 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218491006761 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 218491006762 HMMPfam hit to PF02322, DE Cytochrome oxidase subunit II, score 4.9e-208 218491006763 8 probable transmembrane helices predicted for ECA1366 by TMHMM2.0 at aa 7-24, 77-99, 123-145, 160-182, 203-225, 263-285, 292-314 and 334-356 218491006764 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 218491006765 Signal peptide predicted for ECA1367 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.955 between residues 23 and 24; signal peptide 218491006766 1 probable transmembrane helix predicted for ECA1367 by TMHMM2.0 at aa 2-24 218491006767 hypothetical protein; Provisional; Region: PRK10588 218491006768 3 probable transmembrane helices predicted for ECA1368 by TMHMM2.0 at aa 15-34, 46-68 and 73-95 218491006769 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006770 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 218491006771 active site 218491006772 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site. 218491006773 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03061, DE Thioesterase superfamily, score 1e-37 218491006774 colicin uptake protein TolQ; Provisional; Region: PRK10801 218491006775 3 probable transmembrane helices predicted for ECA1370 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 218491006776 HMMPfam hit to PF01618, DE MotA/TolQ/ExbB proton channel family, score 2.6e-62 218491006777 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218491006778 colicin uptake protein TolR; Provisional; Region: PRK11024 218491006779 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02472, DE Biopolymer transport protein ExbD/TolR, score 4.3e-15 218491006780 1 probable transmembrane helix predicted for ECA1371 by TMHMM2.0 at aa 17-39 218491006781 Signal peptide predicted for ECA1372 by SignalP 2.0 HMM (Signal peptide probabilty 0.841) with cleavage site probability 0.802 between residues 37 and 38; signal peptide 218491006782 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 218491006783 TolA C-terminal; Region: TolA; pfam06519 218491006784 1 probable transmembrane helix predicted for ECA1372 by TMHMM2.0 at aa 13-35 218491006785 Signal peptide predicted for ECA1373 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.994 between residues 21 and 22; signal peptide 218491006786 translocation protein TolB; Provisional; Region: tolB; PRK03629 218491006787 TolB amino-terminal domain; Region: TolB_N; pfam04052 218491006788 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218491006789 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218491006790 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 218491006791 Signal peptide predicted for ECA1374 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.753 between residues 28 and 29; signal peptide 218491006792 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218491006793 ligand binding site [chemical binding]; other site 218491006794 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006795 HMMPfam hit to PF00691, DE OmpA family, score 3.4e-48 218491006796 PS01068 OmpA-like domain. 218491006797 tol-pal system protein YbgF; Provisional; Region: PRK10803 218491006798 Signal peptide predicted for ECA1375 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.800 between residues 26 and 27; signal peptide 218491006799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491006800 binding surface 218491006801 TPR motif; other site 218491006802 Protein of unknown function (DUF554); Region: DUF554; pfam04474 218491006803 7 probable transmembrane helices predicted for ECA1376 by TMHMM2.0 at aa 5-22, 32-50, 57-74, 109-131, 143-165, 180-202 and 214-236 218491006804 hypothetical protein; Provisional; Region: PRK10039 218491006805 quinolinate synthetase; Provisional; Region: PRK09375 218491006806 HMMPfam hit to PF02445, DE Quinolinate synthetase A protein, score 4.5e-182 218491006807 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 218491006808 7 probable transmembrane helices predicted for ECA1379 by TMHMM2.0 at aa 20-39, 46-68, 72-89, 110-132, 158-177, 184-203 and 207-226 218491006809 zinc transporter ZitB; Provisional; Region: PRK03557 218491006810 Signal peptide predicted for ECA1380 by SignalP 2.0 HMM (Signal peptide probabilty 0.660) with cleavage site probability 0.457 between residues 44 and 45; signal peptide 218491006811 HMMPfam hit to PF01545, DE Cation efflux family, score 7.6e-110 218491006812 5 probable transmembrane helices predicted for ECA1380 by TMHMM2.0 at aa 16-38, 48-65, 78-100, 115-137 and 150-172 218491006813 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 218491006814 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218491006815 HMMPfam hit to PF00793, DE DAHP synthetase I family, score 2.3e-177 218491006816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218491006817 catalytic core [active] 218491006818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218491006819 HMMPfam hit to PF00300, DE Phosphoglycerate mutase family, score 1.1e-135 218491006820 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 218491006821 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 218491006822 Signal peptide predicted for ECA1383 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.722 between residues 32 and 33; signal peptide 218491006823 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 0 218491006824 12 probable transmembrane helices predicted for ECA1383 by TMHMM2.0 at aa 13-30, 341-358, 363-385, 389-411, 445-467, 482-504, 531-553, 873-890, 897-919, 923-945, 984-1003 and 1013-1035 218491006825 Signal peptide predicted for ECA1384 by SignalP 2.0 HMM (Signal peptide probabilty 0.886) with cleavage site probability 0.849 between residues 20 and 21; signal peptide 218491006826 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 218491006827 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491006828 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 218491006829 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491006830 Signal peptide predicted for ECA1385 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 25 and 26; signal peptide 218491006831 Outer membrane efflux protein; Region: OEP; pfam02321 218491006832 Outer membrane efflux protein; Region: OEP; pfam02321 218491006833 Signal peptide predicted for ECA1386 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 25 and 26; signal peptide 218491006834 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 218491006835 1 probable transmembrane helix predicted for ECA1387 by TMHMM2.0 at aa 20-39 218491006836 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 218491006837 active site 218491006838 catalytic residues [active] 218491006839 HMMPfam hit to PF01263, DE Aldose 1-epimerase, score 5.8e-106 218491006840 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 218491006841 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 218491006842 NAD binding site [chemical binding]; other site 218491006843 homodimer interface [polypeptide binding]; other site 218491006844 active site 218491006845 substrate binding site [chemical binding]; other site 218491006846 HMMPfam hit to PF01370, DE NAD dependent epimerase/dehydratase family, score 1.5e-164 218491006847 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 218491006848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 218491006849 Walker A/P-loop; other site 218491006850 ATP binding site [chemical binding]; other site 218491006851 Q-loop/lid; other site 218491006852 ABC transporter signature motif; other site 218491006853 Walker B; other site 218491006854 D-loop; other site 218491006855 H-loop/switch region; other site 218491006856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491006857 Walker A/P-loop; other site 218491006858 ATP binding site [chemical binding]; other site 218491006859 Q-loop/lid; other site 218491006860 ABC transporter signature motif; other site 218491006861 Walker B; other site 218491006862 D-loop; other site 218491006863 H-loop/switch region; other site 218491006864 HMMPfam hit to PF00005, DE ABC transporter, score 3.3e-42 218491006865 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006866 HMMPfam hit to PF00005, DE ABC transporter, score 6e-24 218491006867 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006868 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 218491006869 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 218491006870 molybdenum-pterin binding domain; Region: Mop; TIGR00638 218491006871 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 218491006872 HMMPfam hit to PF03459, DE TOBE domain, score 1.7e-12 218491006873 HMMPfam hit to PF02573, DE N-terminal HTH domain of molybdenum-binding protein, score 1.8e-51 218491006874 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 218491006875 Signal peptide predicted for ECA1393 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25; signal peptide 218491006876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 218491006877 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 218491006878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491006879 dimer interface [polypeptide binding]; other site 218491006880 conserved gate region; other site 218491006881 putative PBP binding loops; other site 218491006882 ABC-ATPase subunit interface; other site 218491006883 5 probable transmembrane helices predicted for ECA1394 by TMHMM2.0 at aa 15-37, 49-71, 91-113, 134-156 and 198-220 218491006884 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3e-19 218491006885 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491006886 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 218491006887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491006888 Walker A/P-loop; other site 218491006889 ATP binding site [chemical binding]; other site 218491006890 Q-loop/lid; other site 218491006891 ABC transporter signature motif; other site 218491006892 Walker B; other site 218491006893 D-loop; other site 218491006894 H-loop/switch region; other site 218491006895 molybdenum-pterin binding domain; Region: Mop; TIGR00638 218491006896 HMMPfam hit to PF00005, DE ABC transporter, score 2.2e-58 218491006897 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006898 PS00211 ABC transporters family signature. 218491006899 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03459, DE TOBE domain, score 1.4e-11 218491006900 Signal peptide predicted for ECA1396 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.983 between residues 26 and 27; signal peptide 218491006901 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 218491006902 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491006903 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491006904 DNA binding site [nucleotide binding] 218491006905 domain linker motif; other site 218491006906 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 218491006907 dimerization interface [polypeptide binding]; other site 218491006908 ligand binding site [chemical binding]; other site 218491006909 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 6.1e-23 218491006910 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 7.9e-06 218491006911 Predicted helix-turn-helix motif with score 2385.000, SD 7.31 at aa 1-22, sequence MSIQKIARIAGVSVATVSRVLN 218491006912 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491006913 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491006914 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218491006915 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 0.021 218491006916 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 6.6e-40 218491006917 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 218491006918 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 218491006919 Metal-binding active site; metal-binding site 218491006920 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 218491006921 nucleoside transporter; Region: 2A0110; TIGR00889 218491006922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491006923 putative substrate translocation pore; other site 218491006924 HMMPfam hit to PF03825, DE Nucleoside H+ symporter, score 1.1e-102 218491006925 11 probable transmembrane helices predicted for ECA1400 by TMHMM2.0 at aa 22-44, 56-75, 85-104, 111-133, 153-175, 222-244, 259-277, 284-301, 311-333, 346-368 and 383-405 218491006926 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491006927 glucokinase; Provisional; Region: glk; PRK00292 218491006928 glucokinase, proteobacterial type; Region: glk; TIGR00749 218491006929 HMMPfam hit to PF02685, DE Glucokinase, score 4.3e-187 218491006930 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 218491006931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491006932 active site 218491006933 motif I; other site 218491006934 motif II; other site 218491006935 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491006936 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 9.2e-07 218491006937 PS01229 Hypothetical cof family signature 2. 218491006938 PS01228 Hypothetical cof family signature 1. 218491006939 6-phosphogluconolactonase; Provisional; Region: PRK11028 218491006940 Uncharacterized conserved protein [Function unknown]; Region: COG5276 218491006941 Signal peptide predicted for ECA1405 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 21 and 22; signal peptide 218491006942 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 218491006943 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 218491006944 putative ligand binding site [chemical binding]; other site 218491006945 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 218491006946 Signal peptide predicted for ECA1406 by SignalP 2.0 HMM (Signal peptide probabilty 0.887) with cleavage site probability 0.387 between residues 41 and 42; signal peptide 218491006947 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 218491006948 4 probable transmembrane helices predicted for ECA1406 by TMHMM2.0 at aa 20-42, 55-77, 117-139 and 154-176 218491006949 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 218491006950 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 218491006951 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00028 218491006952 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491006953 Signal peptide predicted for ECA1408 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.780 between residues 33 and 34; signal peptide 218491006954 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 218491006955 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 218491006956 [4Fe-4S] binding site [ion binding]; other site 218491006957 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218491006958 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 218491006959 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 218491006960 molybdopterin cofactor binding site; other site 218491006961 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 4.3e-33 218491006962 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 2.1e-31 218491006963 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 218491006964 1 probable transmembrane helix predicted for ECA1408 by TMHMM2.0 at aa 7-29 218491006965 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 218491006966 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 218491006967 active site 218491006968 HIGH motif; other site 218491006969 KMSKS motif; other site 218491006970 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 218491006971 tRNA binding surface [nucleotide binding]; other site 218491006972 anticodon binding site; other site 218491006973 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 218491006974 dimer interface [polypeptide binding]; other site 218491006975 putative tRNA-binding site [nucleotide binding]; other site 218491006976 HMMPfam hit to PF01588, DE tRNA binding domain, score 1e-36 218491006977 HMMPfam hit to PF00133, DE tRNA synthetases class I (I, L, M and V), score 0.00011 218491006978 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491006979 antiporter inner membrane protein; Provisional; Region: PRK11670 218491006980 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 218491006981 Walker A motif; other site 218491006982 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006983 PS01215 Mrp family signature. 218491006984 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 218491006985 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 218491006986 Sugar specificity; other site 218491006987 Pyrimidine base specificity; other site 218491006988 ATP-binding site [chemical binding]; other site 218491006989 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00485, DE Phosphoribulokinase / Uridine kinase family, score 2.1e-28 218491006990 PS00017 ATP/GTP-binding site motif A (P-loop). 218491006991 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218491006992 trimer interface [polypeptide binding]; other site 218491006993 active site 218491006994 HMMPfam hit to PF00692, DE dUTPase, score 1.7e-31 218491006995 putative assembly protein; Provisional; Region: PRK10833 218491006996 Signal peptide predicted for ECA1413 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.778 between residues 26 and 27; signal peptide 218491006997 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 218491006998 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 218491006999 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 218491007000 9 probable transmembrane helices predicted for ECA1414 by TMHMM2.0 at aa 21-43, 78-100, 121-143, 158-180, 192-214, 265-287, 308-330, 345-367 and 429-448 218491007001 HMMPfam hit to PF03606, DE C4-dicarboxylate anaerobic carrier, score 4e-177 218491007002 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 218491007003 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 218491007004 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218491007005 Transporter associated domain; Region: CorC_HlyC; smart01091 218491007006 HMMPfam hit to PF03471, DE Transporter associated domain, score 1.1e-26 218491007007 HMMPfam hit to PF00571, DE CBS domain, score 1.8e-09 218491007008 HMMPfam hit to PF00571, DE CBS domain, score 2.1e-07 218491007009 PS00125 Serine/threonine specific protein phosphatases signature. 218491007010 HMMPfam hit to PF03741, DE Integral membrane protein TerC family, score 9.4e-80 218491007011 6 probable transmembrane helices predicted for ECA1415 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 155-172 and 185-207 218491007012 exopolysaccharide biosynthesis and O antigen biosynthesis clusters. Also a low %GC region 218491007013 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 218491007014 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 218491007015 Mg++ binding site [ion binding]; other site 218491007016 putative catalytic motif [active] 218491007017 substrate binding site [chemical binding]; other site 218491007018 11 probable transmembrane helices predicted for ECA1416 by TMHMM2.0 at aa 15-32, 53-75, 80-97, 104-126, 139-161, 168-187, 192-214, 221-243, 253-275, 302-319 and 329-351 218491007019 HMMPfam hit to PF00953, DE Glycosyl transferase, score 4e-06 218491007020 polysaccharide export protein Wza; Provisional; Region: PRK15078 218491007021 Signal peptide predicted for ECA1417 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.505 between residues 29 and 30; signal peptide 218491007022 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 218491007023 HMMPfam hit to PF02563, DE Polysaccharide biosynthesis/export protein, score 4.2e-172 218491007024 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007025 Low molecular weight phosphatase family; Region: LMWPc; cd00115 218491007026 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 218491007027 active site 218491007028 HMMPfam hit to PF01451, DE Low molecular weight phosphotyrosine protein phosphatase, score 1.4e-54 218491007029 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007030 tyrosine kinase; Provisional; Region: PRK11519 218491007031 Chain length determinant protein; Region: Wzz; pfam02706 218491007032 Chain length determinant protein; Region: Wzz; cl15801 218491007033 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 218491007034 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 218491007035 Nucleotide binding site [chemical binding]; other site 218491007036 DTAP/Switch II; other site 218491007037 Switch I; other site 218491007038 HMMPfam hit to PF02706, DE Chain length determinant protein, score 1.7e-72 218491007039 2 probable transmembrane helices predicted for ECA1419 by TMHMM2.0 at aa 31-53 and 424-443 218491007040 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491007041 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007042 Signal peptide predicted for ECA1420 by SignalP 2.0 HMM (Signal peptide probabilty 0.823) with cleavage site probability 0.602 between residues 45 and 46; signal peptide 218491007043 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 218491007044 Bacterial sugar transferase; Region: Bac_transf; pfam02397 218491007045 5 probable transmembrane helices predicted for ECA1420 by TMHMM2.0 at aa 22-44, 54-71, 90-107, 117-134 and 286-308 218491007046 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02397, DE Bacterial sugar transferase, score 6.4e-152 218491007047 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 218491007048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218491007049 catalytic loop [active] 218491007050 iron binding site [ion binding]; other site 218491007051 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 218491007052 FAD binding pocket [chemical binding]; other site 218491007053 FAD binding motif [chemical binding]; other site 218491007054 phosphate binding motif [ion binding]; other site 218491007055 beta-alpha-beta structure motif; other site 218491007056 NAD binding pocket [chemical binding]; other site 218491007057 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 0.065 218491007058 HMMPfam hit to PF00970, DE Oxidoreductase FAD-binding domain, score 2.1e-23 218491007059 HMMPfam hit to PF00175, DE Oxidoreductase NAD-binding domain, score 1.1e-24 218491007060 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 218491007061 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 218491007062 substrate binding site; other site 218491007063 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 1.2e-07 218491007064 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 218491007065 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 218491007066 NAD binding site [chemical binding]; other site 218491007067 homotetramer interface [polypeptide binding]; other site 218491007068 homodimer interface [polypeptide binding]; other site 218491007069 substrate binding site [chemical binding]; other site 218491007070 active site 218491007071 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 218491007072 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218491007073 inhibitor-cofactor binding pocket; inhibition site 218491007074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491007075 catalytic residue [active] 218491007076 HMMPfam hit to PF01041, DE DegT/DnrJ/EryC1/StrS aminotransferase family, score 1e-161 218491007077 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 218491007078 HMMPfam hit to PF03328, DE HpcH/HpaI aldolase family, score 5.9e-39 218491007079 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 218491007080 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 218491007081 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491007082 PYR/PP interface [polypeptide binding]; other site 218491007083 dimer interface [polypeptide binding]; other site 218491007084 TPP binding site [chemical binding]; other site 218491007085 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491007086 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 218491007087 TPP-binding site [chemical binding]; other site 218491007088 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 4.4e-44 218491007089 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 2.2e-18 218491007090 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 2e-29 218491007091 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218491007092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491007093 NAD(P) binding site [chemical binding]; other site 218491007094 active site 218491007095 Predicted helix-turn-helix motif with score 1046.000, SD 2.75 at aa 37-58, sequence QTQSWLAENGITSRCSVNQYEE 218491007096 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 218491007097 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218491007098 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 218491007099 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02396, DE Acetaldehyde dehydrogenase, score 2.2e-101 218491007100 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 218491007101 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 218491007102 active site 218491007103 catalytic residues [active] 218491007104 metal binding site [ion binding]; metal-binding site 218491007105 DmpG-like communication domain; Region: DmpG_comm; pfam07836 218491007106 HMMPfam hit to PF00682, DE HMGL-like, score 9.3e-51 218491007107 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218491007108 extended (e) SDRs; Region: SDR_e; cd08946 218491007109 NAD(P) binding site [chemical binding]; other site 218491007110 active site 218491007111 substrate binding site [chemical binding]; other site 218491007112 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 218491007113 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 218491007114 12 probable transmembrane helices predicted for ECA1431 by TMHMM2.0 at aa 7-29, 47-69, 89-111, 126-148, 153-175, 185-202, 223-242, 252-274, 295-317, 332-354, 366-388 and 392-414 218491007115 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218491007116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218491007117 active site 218491007118 HMMPfam hit to PF00535, DE Glycosyl transferase, score 5.1e-22 218491007119 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 218491007120 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 218491007121 trimer interface [polypeptide binding]; other site 218491007122 active site 218491007123 substrate binding site [chemical binding]; other site 218491007124 CoA binding site [chemical binding]; other site 218491007125 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 4.5e+02 218491007126 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1.5e+02 218491007127 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 50 218491007128 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 13 218491007129 PS00101 Hexapeptide-repeat containing-transferases signature. 218491007130 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 3.8 218491007131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218491007132 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218491007133 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 1.6e-22 218491007134 11 probable transmembrane helices predicted for ECA1435 by TMHMM2.0 at aa 4-21, 26-45, 60-82, 102-120, 140-162, 169-186, 190-207, 214-236, 321-343, 356-373 and 378-395 218491007135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218491007136 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 218491007137 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 2.1e-25 218491007138 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 218491007139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218491007140 active site 218491007141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218491007142 HMMPfam hit to PF00535, DE Glycosyl transferase, score 1.5e-22 218491007143 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 218491007144 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 218491007145 Substrate binding site; other site 218491007146 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 218491007147 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 6.4e-125 218491007148 HMMPfam hit to PF01050, DE Mannose-6-phosphate isomerase, score 6.1e-100 218491007149 phosphomannomutase CpsG; Provisional; Region: PRK15414 218491007150 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 218491007151 active site 218491007152 substrate binding site [chemical binding]; other site 218491007153 metal binding site [ion binding]; metal-binding site 218491007154 HMMPfam hit to PF02878, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 9.6e-42 218491007155 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218491007156 HMMPfam hit to PF02879, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 7.9e-53 218491007157 HMMPfam hit to PF02880, DE Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 1.2e-48 218491007158 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00408, DE Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 5.2e-26 218491007159 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 218491007160 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 218491007161 NADP binding site [chemical binding]; other site 218491007162 active site 218491007163 putative substrate binding site [chemical binding]; other site 218491007164 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 218491007165 HMMPfam hit to PF00908, DE dTDP-4-dehydrorhamnose 3,5-epimerase, score 1.5e-104 218491007166 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 218491007167 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 218491007168 substrate binding site; other site 218491007169 tetramer interface; other site 218491007170 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 5.1e-111 218491007171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218491007172 active site 218491007173 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 5.4e-06 218491007174 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218491007175 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 218491007176 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 218491007177 HMMPfam hit to PF03446, DE NAD binding domain of 6-phosphogluconate dehydrogenase, score 2.7e-120 218491007178 HMMPfam hit to PF00393, DE 6-phosphogluconate dehydrogenase, C-terminal domain, score 1.6e-232 218491007179 PS00461 6-phosphogluconate dehydrogenase signature. 218491007180 Signal peptide predicted for ECA1445 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.925 between residues 20 and 21; signal peptide 218491007181 2 probable transmembrane helices predicted for ECA1445 by TMHMM2.0 at aa 24-46 and 61-83 218491007182 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 218491007183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007184 Signal peptide predicted for ECA1447 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.961 between residues 20 and 21; signal peptide 218491007185 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 218491007186 Signal peptide predicted for ECA1448 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 26 and 27; signal peptide 218491007187 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 218491007188 chorismate mutase; Provisional; Region: PRK08055 218491007189 Signal peptide predicted for ECA1449 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24; signal peptide 218491007190 HMMPfam hit to PF01817, DE Chorismate mutase, score 2.4e-05 218491007191 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 218491007192 peptidase domain interface [polypeptide binding]; other site 218491007193 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 218491007194 active site 218491007195 catalytic triad [active] 218491007196 calcium binding site [ion binding]; other site 218491007197 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 218491007198 beta-galactosidase; Region: BGL; TIGR03356 218491007199 HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 1.3e-188 218491007200 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491007201 PS00572 Glycosyl hydrolases family 1 active site. 218491007202 transcriptional antiterminator BglG; Provisional; Region: PRK09772 218491007203 CAT RNA binding domain; Region: CAT_RBD; smart01061 218491007204 PRD domain; Region: PRD; pfam00874 218491007205 PRD domain; Region: PRD; pfam00874 218491007206 HMMPfam hit to PF03123, DE CAT RNA binding domain, score 1.1e-11 218491007207 HMMPfam hit to PF00874, DE PRD domain, score 4.4e-38 218491007208 PS00654 Transcriptional antiterminators bglG family signature. 218491007209 HMMPfam hit to PF00874, DE PRD domain, score 2.6e-06 218491007210 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 218491007211 MASE2 domain; Region: MASE2; pfam05230 218491007212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491007213 metal binding site [ion binding]; metal-binding site 218491007214 active site 218491007215 I-site; other site 218491007216 5 probable transmembrane helices predicted for ECA1453 by TMHMM2.0 at aa 24-45, 50-72, 92-114, 129-151 and 158-180 218491007217 HMMPfam hit to PF00990, DE GGDEF domain, score 1.9e-53 218491007218 Uncharacterized conserved protein [Function unknown]; Region: COG1359 218491007219 HMMPfam hit to PF02619, , score 5.9e-12 218491007220 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 218491007221 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218491007222 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218491007223 putative active site [active] 218491007224 HMMPfam hit to PF01380, DE SIS domain, score 0.019 218491007225 HMMPfam hit to PF01418, DE Helix-turn-helix domain, rpiR family, score 7.4e-06 218491007226 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 218491007227 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 218491007228 tetrameric interface [polypeptide binding]; other site 218491007229 NAD binding site [chemical binding]; other site 218491007230 catalytic residues [active] 218491007231 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 1e-171 218491007232 PS00070 Aldehyde dehydrogenases cysteine active site. 218491007233 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 218491007234 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491007235 PYR/PP interface [polypeptide binding]; other site 218491007236 dimer interface [polypeptide binding]; other site 218491007237 TPP binding site [chemical binding]; other site 218491007238 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491007239 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 218491007240 TPP-binding site; other site 218491007241 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 7.1e-25 218491007242 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 2.1e-29 218491007243 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 1.3e-35 218491007244 PS00187 Thiamine pyrophosphate enzymes signature. 218491007245 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491007246 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491007247 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218491007248 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 1e-24 218491007249 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 2.9e-08 218491007250 Signal peptide predicted for ECA1459 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 22 and 23; signal peptide 218491007251 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 218491007252 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 218491007253 ligand binding site [chemical binding]; other site 218491007254 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 6.6e-06 218491007255 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 218491007256 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491007257 Walker A/P-loop; other site 218491007258 ATP binding site [chemical binding]; other site 218491007259 Q-loop/lid; other site 218491007260 ABC transporter signature motif; other site 218491007261 Walker B; other site 218491007262 D-loop; other site 218491007263 H-loop/switch region; other site 218491007264 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491007265 HMMPfam hit to PF00005, DE ABC transporter, score 4.2e-53 218491007266 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007267 HMMPfam hit to PF00005, DE ABC transporter, score 9.5e-21 218491007268 PS00211 ABC transporters family signature. 218491007269 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491007270 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491007271 TM-ABC transporter signature motif; other site 218491007272 10 probable transmembrane helices predicted for ECA1461 by TMHMM2.0 at aa 21-43, 58-80, 82-99, 114-136, 143-165, 185-207, 235-254, 264-286, 291-310 and 315-332 218491007273 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 0.0011 218491007274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491007275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491007276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218491007277 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 1.1e-36 218491007278 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 1.2e-09 218491007279 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218491007280 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218491007281 substrate binding site [chemical binding]; other site 218491007282 ATP binding site [chemical binding]; other site 218491007283 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 218491007284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 218491007285 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 2.2e-48 218491007286 PS00584 pfkB family of carbohydrate kinases signature 2. 218491007287 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 218491007288 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 218491007289 Metal-binding active site; metal-binding site 218491007290 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 218491007291 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 218491007292 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 218491007293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218491007294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491007295 Walker A/P-loop; other site 218491007296 ATP binding site [chemical binding]; other site 218491007297 Q-loop/lid; other site 218491007298 ABC transporter signature motif; other site 218491007299 Walker B; other site 218491007300 D-loop; other site 218491007301 H-loop/switch region; other site 218491007302 HMMPfam hit to PF00005, DE ABC transporter, score 3e-59 218491007303 PS00211 ABC transporters family signature. 218491007304 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007305 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 218491007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007307 dimer interface [polypeptide binding]; other site 218491007308 conserved gate region; other site 218491007309 putative PBP binding loops; other site 218491007310 ABC-ATPase subunit interface; other site 218491007311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007312 dimer interface [polypeptide binding]; other site 218491007313 conserved gate region; other site 218491007314 putative PBP binding loops; other site 218491007315 ABC-ATPase subunit interface; other site 218491007316 11 probable transmembrane helices predicted for ECA1469 by TMHMM2.0 at aa 28-50, 73-95, 102-124, 159-181, 194-216, 256-278, 305-327, 350-372, 392-414, 429-451 and 535-554 218491007317 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4.8e-05 218491007318 PS00216 Sugar transport proteins signature 1. 218491007319 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 8.8e-13 218491007320 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491007321 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007322 Signal peptide predicted for ECA1470 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 31 and 32; signal peptide 218491007323 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 218491007324 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 218491007325 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 4.5e-05 218491007326 1 probable transmembrane helix predicted for ECA1470 by TMHMM2.0 at aa 13-32 218491007327 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491007328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491007329 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 218491007330 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 218491007331 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 218491007332 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 218491007333 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 218491007334 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 218491007335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491007336 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491007337 PS00041 Bacterial regulatory proteins, araC family signature. 218491007338 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 3.3e-06 218491007339 Predicted helix-turn-helix motif with score 1027.000, SD 2.68 at aa 204-225, sequence LRIDALCEVSGMSRASLHRHFL 218491007340 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.0056 218491007341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491007342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491007343 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491007344 putative effector binding pocket; other site 218491007345 dimerization interface [polypeptide binding]; other site 218491007346 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.9e-42 218491007347 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.8e-19 218491007348 PS00044 Bacterial regulatory proteins, lysR family signature. 218491007349 Predicted helix-turn-helix motif with score 1744.000, SD 5.13 at aa 23-44, sequence GSYTAAARSLSVSPSAISKSIQ 218491007350 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 218491007351 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 218491007352 putative NAD(P) binding site [chemical binding]; other site 218491007353 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 1.3e-58 218491007354 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 218491007355 TMP-binding site; other site 218491007356 ATP-binding site [chemical binding]; other site 218491007357 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491007359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491007360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491007361 dimerization interface [polypeptide binding]; other site 218491007362 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.2e-24 218491007363 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.5e-23 218491007364 PS00044 Bacterial regulatory proteins, lysR family signature. 218491007365 Predicted helix-turn-helix motif with score 1700.000, SD 4.98 at aa 19-40, sequence GSITAAARKLEITPPSVSKSLK 218491007366 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 218491007367 HMMPfam hit to PF02525, DE Flavodoxin-like fold, score 6.9e-27 218491007368 YCII-related domain; Region: YCII; cl00999 218491007369 HMMPfam hit to PF03795, DE YCII-related domain, score 1.2e-05 218491007370 Signal peptide predicted for ECA1485 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.902 between residues 19 and 20; signal peptide 218491007371 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 218491007372 Uncharacterized conserved protein [Function unknown]; Region: COG1359 218491007373 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491007375 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 218491007376 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 218491007377 Walker A/P-loop; other site 218491007378 ATP binding site [chemical binding]; other site 218491007379 Q-loop/lid; other site 218491007380 ABC transporter signature motif; other site 218491007381 Walker B; other site 218491007382 D-loop; other site 218491007383 H-loop/switch region; other site 218491007384 HMMPfam hit to PF00005, DE ABC transporter, score 5.7e-40 218491007385 PS00211 ABC transporters family signature. 218491007386 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007387 6 probable transmembrane helices predicted for ECA1486 by TMHMM2.0 at aa 24-46, 61-83, 128-150, 154-176, 239-261 and 276-298 218491007388 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 0.0042 218491007389 Condensation domain; Region: Condensation; pfam00668 218491007390 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491007391 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 218491007392 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007393 acyl-activating enzyme (AAE) consensus motif; other site 218491007394 AMP binding site [chemical binding]; other site 218491007395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007396 Condensation domain; Region: Condensation; pfam00668 218491007397 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007398 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007399 acyl-activating enzyme (AAE) consensus motif; other site 218491007400 AMP binding site [chemical binding]; other site 218491007401 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007402 Condensation domain; Region: Condensation; pfam00668 218491007403 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491007404 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007405 acyl-activating enzyme (AAE) consensus motif; other site 218491007406 AMP binding site [chemical binding]; other site 218491007407 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007408 Condensation domain; Region: Condensation; pfam00668 218491007409 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007410 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007411 acyl-activating enzyme (AAE) consensus motif; other site 218491007412 AMP binding site [chemical binding]; other site 218491007413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007414 Condensation domain; Region: Condensation; pfam00668 218491007415 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007416 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007417 acyl-activating enzyme (AAE) consensus motif; other site 218491007418 AMP binding site [chemical binding]; other site 218491007419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007420 Condensation domain; Region: Condensation; pfam00668 218491007421 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491007422 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007423 acyl-activating enzyme (AAE) consensus motif; other site 218491007424 AMP binding site [chemical binding]; other site 218491007425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007426 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 218491007427 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 218491007428 HMMPfam hit to PF00975, DE Thioesterase domain, score 1.5e-27 218491007429 HMMPfam hit to PF00975, DE Thioesterase domain, score 1.5e-22 218491007430 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2.4e-15 218491007431 PS00012 Phosphopantetheine attachment site. 218491007432 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 2.7e-187 218491007433 PS00455 AMP-binding domain signature. 218491007434 HMMPfam hit to PF00668, DE Condensation domain, score 8.3e-35 218491007435 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 8.2e-15 218491007436 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 8.1e-167 218491007437 PS00455 AMP-binding domain signature. 218491007438 HMMPfam hit to PF00668, DE Condensation domain, score 3e-37 218491007439 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2.8e-15 218491007440 PS00012 Phosphopantetheine attachment site. 218491007441 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 2.4e-169 218491007442 PS00455 AMP-binding domain signature. 218491007443 HMMPfam hit to PF00668, DE Condensation domain, score 9.3e-42 218491007444 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 4.6e-14 218491007445 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 3.4e-186 218491007446 PS00455 AMP-binding domain signature. 218491007447 HMMPfam hit to PF00668, DE Condensation domain, score 4.2e-48 218491007448 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 3.9e-11 218491007449 PS00012 Phosphopantetheine attachment site. 218491007450 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.4e-166 218491007451 PS00455 AMP-binding domain signature. 218491007452 HMMPfam hit to PF00668, DE Condensation domain, score 7e-46 218491007453 Predicted helix-turn-helix motif with score 1423.000, SD 4.03 at aa 789-1389, sequence LERTRLINMYGITEITVHATFRELSAADITAGRGSLIGRPLPDLRAYLLDPHGQPVP VGVAGELYIGGAGVARGYLNRPDLTAERFIVDPFSDSPATRLYKTGDLARWLPDGTL DYLGRNDFQVKVRGFRIELGEIESRLVQCPGVQEAVVLAREDVPGDTRLVAYIQPQP KAVLEPADLRQQLSTHLADYMIPAAFVTLEAFPLTPNGKLDRKALPAPERSAVVTRG YEEPVGDIETALAEIWQDLLGLERVGRYDHFFELGGHSLLIVSLIEKLRHLGLKLDV RSVFTAPTLIELADAIQHDRGESRFITPDNLIPNGAERITPEMLPLVALSQQEIDAI TDTVSGGAANIQDIYPLASLQEGILFHHRLHPDNDPYVVSSLLRVANETKLDAFIAA LQSVINRHDILRTSIHWTELTQPVQVVHRHATLNVHRLEPENSVDVVTTMRERVVSS HASMDLSQAPLMHLYVAPDSTSPALYILLQFHHIIDDNLSLRQLLAETTAFLMGKGE ALPPSFPYRNFVAYTRQEDKNHAAEAFFQDYLADIDEITAPFGVANVQASGENAAEA RQSLSPELSQTIRDAARRFGISPAALFHASW 218491007454 Predicted helix-turn-helix motif with score 1423.000, SD 4.03 at aa 1368-1389, sequence QTIRDAARRFGISPAALFHASW 218491007455 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2.2e-16 218491007456 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.7e-178 218491007457 Predicted helix-turn-helix motif with score 1040.000, SD 2.73 at aa 789-810, sequence LERTRLINMYGITEITVHATFR 218491007458 PS00455 AMP-binding domain signature. 218491007459 PS00850 Glycine radical signature. 218491007460 HMMPfam hit to PF00668, DE Condensation domain, score 4.6e-95 218491007461 Condensation domain; Region: Condensation; pfam00668 218491007462 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007463 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007464 acyl-activating enzyme (AAE) consensus motif; other site 218491007465 AMP binding site [chemical binding]; other site 218491007466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007467 Condensation domain; Region: Condensation; pfam00668 218491007468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007469 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007470 acyl-activating enzyme (AAE) consensus motif; other site 218491007471 AMP binding site [chemical binding]; other site 218491007472 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007473 Condensation domain; Region: Condensation; pfam00668 218491007474 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491007475 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 218491007476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007477 acyl-activating enzyme (AAE) consensus motif; other site 218491007478 AMP binding site [chemical binding]; other site 218491007479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007480 Condensation domain; Region: Condensation; pfam00668 218491007481 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007482 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007483 acyl-activating enzyme (AAE) consensus motif; other site 218491007484 AMP binding site [chemical binding]; other site 218491007485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007486 Condensation domain; Region: Condensation; pfam00668 218491007487 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007488 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007489 acyl-activating enzyme (AAE) consensus motif; other site 218491007490 AMP binding site [chemical binding]; other site 218491007491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007492 Condensation domain; Region: Condensation; pfam00668 218491007493 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 218491007494 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 218491007495 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007496 acyl-activating enzyme (AAE) consensus motif; other site 218491007497 AMP binding site [chemical binding]; other site 218491007498 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007499 Condensation domain; Region: Condensation; pfam00668 218491007500 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 218491007501 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491007502 acyl-activating enzyme (AAE) consensus motif; other site 218491007503 AMP binding site [chemical binding]; other site 218491007504 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491007505 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 4.5e-18 218491007506 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 4.6e-167 218491007507 PS00455 AMP-binding domain signature. 218491007508 HMMPfam hit to PF00668, DE Condensation domain, score 1.4e-37 218491007509 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 6.5e-13 218491007510 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 8e-187 218491007511 PS00455 AMP-binding domain signature. 218491007512 HMMPfam hit to PF00668, DE Condensation domain, score 9.5e-105 218491007513 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 3.3e-18 218491007514 PS00012 Phosphopantetheine attachment site. 218491007515 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.5e-164 218491007516 PS00455 AMP-binding domain signature. 218491007517 HMMPfam hit to PF00668, DE Condensation domain, score 4.5e-37 218491007518 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2.7e-12 218491007519 PS00012 Phosphopantetheine attachment site. 218491007520 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 2.8e-168 218491007521 PS00455 AMP-binding domain signature. 218491007522 HMMPfam hit to PF00668, DE Condensation domain, score 8e-33 218491007523 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2.4e-13 218491007524 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 8.5e-186 218491007525 PS00455 AMP-binding domain signature. 218491007526 HMMPfam hit to PF00668, DE Condensation domain, score 3.3e-104 218491007527 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2e-13 218491007528 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 2.2e-158 218491007529 PS00455 AMP-binding domain signature. 218491007530 HMMPfam hit to PF00668, DE Condensation domain, score 1.1e-29 218491007531 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 2e-09 218491007532 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 4.2e-160 218491007533 PS00455 AMP-binding domain signature. 218491007534 HMMPfam hit to PF00668, DE Condensation domain, score 1.6e-41 218491007535 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007536 galactoside permease; Reviewed; Region: lacY; PRK09528 218491007537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491007538 putative substrate translocation pore; other site 218491007539 HMMPfam hit to PF01306, DE LacY proton/sugar symporter, score 6.1e-283 218491007540 12 probable transmembrane helices predicted for ECA1489 by TMHMM2.0 at aa 13-35, 45-67, 76-98, 103-125, 145-164, 168-187, 222-239, 261-283, 290-309, 324-341, 348-370 and 380-402 218491007541 PS00897 LacY family proton/sugar symporters signature 2. 218491007542 PS00896 LacY family proton/sugar symporters signature 1. 218491007543 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 218491007544 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 218491007545 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 218491007546 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 218491007547 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 218491007548 HMMPfam hit to PF02930, DE Beta galactosidase small chain, C terminal domain, score 4.5e-37 218491007549 HMMPfam hit to PF02929, DE Beta galactosidase small chain, N terminal domain, score 5.1e-68 218491007550 HMMPfam hit to PF02836, DE Glycosyl hydrolases family 2, TIM barrel domain, score 2.9e-181 218491007551 PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 218491007552 PS00719 Glycosyl hydrolases family 2 signature 1. 218491007553 HMMPfam hit to PF00703, DE Glycosyl hydrolases family 2, immunoglobulin-like beta-sandwich domain, score 2.9e-32 218491007554 HMMPfam hit to PF02837, DE Glycosyl hydrolases family 2, sugar binding domain, score 1.3e-107 218491007555 lac repressor; Reviewed; Region: lacI; PRK09526 218491007556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491007557 DNA binding site [nucleotide binding] 218491007558 domain linker motif; other site 218491007559 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 218491007560 ligand binding site [chemical binding]; other site 218491007561 dimerization interface (open form) [polypeptide binding]; other site 218491007562 dimerization interface (closed form) [polypeptide binding]; other site 218491007563 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 4.4e-07 218491007564 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007565 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 5.4e-12 218491007566 Predicted helix-turn-helix motif with score 2202.000, SD 6.69 at aa 6-27, sequence ITLHDVAEYAGVSYQTVSRVLN 218491007567 PS00356 Bacterial regulatory proteins, lacI family signature. 218491007568 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 218491007569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491007570 Walker A/P-loop; other site 218491007571 ATP binding site [chemical binding]; other site 218491007572 Q-loop/lid; other site 218491007573 ABC transporter signature motif; other site 218491007574 Walker B; other site 218491007575 D-loop; other site 218491007576 H-loop/switch region; other site 218491007577 TOBE domain; Region: TOBE_2; pfam08402 218491007578 HMMPfam hit to PF00005, DE ABC transporter, score 1.5e-68 218491007579 PS00211 ABC transporters family signature. 218491007580 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007581 Signal peptide predicted for ECA1493 by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.927 between residues 34 and 35; signal peptide 218491007582 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 218491007583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007584 dimer interface [polypeptide binding]; other site 218491007585 conserved gate region; other site 218491007586 putative PBP binding loops; other site 218491007587 ABC-ATPase subunit interface; other site 218491007588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007589 dimer interface [polypeptide binding]; other site 218491007590 conserved gate region; other site 218491007591 putative PBP binding loops; other site 218491007592 ABC-ATPase subunit interface; other site 218491007593 16 probable transmembrane helices predicted for ECA1494 by TMHMM2.0 at aa 16-38, 53-75, 87-105, 110-132, 145-167, 196-218, 231-253, 273-295, 325-347, 381-403, 424-446, 488-510, 519-541, 546-568, 611-633 and 656-678 218491007594 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 5.7e-10 218491007595 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.3e-07 218491007596 Signal peptide predicted for ECA1494 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.634 between residues 26 and 27; signal peptide 218491007597 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218491007598 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 218491007599 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 1.3e-08 218491007600 regulatory protein UhpC; Provisional; Region: PRK11663 218491007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491007602 putative substrate translocation pore; other site 218491007603 10 probable transmembrane helices predicted for ECA1496 by TMHMM2.0 at aa 26-48, 63-85, 92-123, 177-199, 242-264, 284-306, 318-337, 342-364, 377-399 and 409-431 218491007604 Signal peptide predicted for ECA1496 by SignalP 2.0 HMM (Signal peptide probabilty 0.908) with cleavage site probability 0.469 between residues 37 and 38; signal peptide 218491007605 MASE1; Region: MASE1; pfam05231 218491007606 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 218491007607 Histidine kinase; Region: HisKA_3; pfam07730 218491007608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491007609 ATP binding site [chemical binding]; other site 218491007610 Mg2+ binding site [ion binding]; other site 218491007611 G-X-G motif; other site 218491007612 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.4e-17 218491007613 Predicted helix-turn-helix motif with score 1002.000, SD 2.60 at aa 354-375, sequence GQISELSRRIHHTTRQLLRQLR 218491007614 5 probable transmembrane helices predicted for ECA1497 by TMHMM2.0 at aa 7-29, 77-99, 112-134, 138-160 and 210-232 218491007615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218491007616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491007617 active site 218491007618 phosphorylation site [posttranslational modification] 218491007619 intermolecular recognition site; other site 218491007620 dimerization interface [polypeptide binding]; other site 218491007621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491007622 DNA binding residues [nucleotide binding] 218491007623 dimerization interface [polypeptide binding]; other site 218491007624 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 1.6e-24 218491007625 PS00622 Bacterial regulatory proteins, luxR family signature. 218491007626 Predicted helix-turn-helix motif with score 1139.000, SD 3.07 at aa 170-191, sequence ISVKSIAEQLELSHKTVHVHRA 218491007627 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.6e-29 218491007628 Signal peptide predicted for ECA1498 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.678 between residues 21 and 22; signal peptide 218491007629 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 218491007630 lipoprotein, YaeC family; Region: TIGR00363 218491007631 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007632 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03180, DE NLPA lipoprotein, score 2.2e-126 218491007633 Pectate lyase; Region: Pec_lyase_C; pfam00544 218491007634 HMMPfam hit to PF00544, DE Pectate lyase, score 1.7e-118 218491007635 aspartate racemase; Region: asp_race; TIGR00035 218491007636 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 218491007637 HMMPfam hit to PF01177, DE Asp/Glu/Hydantoin racemase, score 1.5e-09 218491007638 PS00924 Aspartate and glutamate racemases signature 2. 218491007639 PS00923 Aspartate and glutamate racemases signature 1. 218491007640 cell density-dependent motility repressor; Provisional; Region: PRK10082 218491007641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491007642 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491007643 dimerization interface [polypeptide binding]; other site 218491007644 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.2e-16 218491007645 Predicted helix-turn-helix motif with score 1421.000, SD 4.03 at aa 20-41, sequence RSFTLAAEKRNISQSSFSRRIQ 218491007646 PS00044 Bacterial regulatory proteins, lysR family signature. 218491007647 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 7.8e-08 218491007648 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 218491007649 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218491007650 HMMPfam hit to PF00375, DE Sodium:dicarboxylate symporter family, score 1.9e-115 218491007651 8 probable transmembrane helices predicted for ECA1504 by TMHMM2.0 at aa 36-53, 80-102, 114-136, 183-200, 227-249, 259-281, 346-368 and 388-410 218491007652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491007653 DNA-binding site [nucleotide binding]; DNA binding site 218491007654 Transcriptional regulators [Transcription]; Region: GntR; COG1802 218491007655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 218491007656 DNA-binding site [nucleotide binding]; DNA binding site 218491007657 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218491007658 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 218491007659 Signal peptide predicted for ECA1506 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.985 between residues 38 and 39; signal peptide 218491007660 Citrate transporter; Region: CitMHS; pfam03600 218491007661 HMMPfam hit to PF03600, DE Citrate transporter, score 1.5e-247 218491007662 11 probable transmembrane helices predicted for ECA1506 by TMHMM2.0 at aa 2-19, 23-45, 65-87, 107-129, 136-158, 173-195, 239-261, 289-311, 318-340, 350-369 and 410-432 218491007663 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 218491007664 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 218491007665 [4Fe-4S] binding site [ion binding]; other site 218491007666 molybdopterin cofactor binding site; other site 218491007667 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 218491007668 molybdopterin cofactor binding site; other site 218491007669 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 4.7e-32 218491007670 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 1.9e-198 218491007671 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 218491007672 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 218491007673 Signal peptide predicted for ECA1509 by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.554 between residues 29 and 30; signal peptide 218491007674 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 218491007675 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491007676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491007677 dimer interface [polypeptide binding]; other site 218491007678 putative CheW interface [polypeptide binding]; other site 218491007679 2 probable transmembrane helices predicted for ECA1509 by TMHMM2.0 at aa 13-35 and 193-212 218491007680 Predicted helix-turn-helix motif with score 1072.000, SD 2.84 at aa 102-123, sequence LEKFQASEHVGVNQATVDAVKN 218491007681 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 2.1e-93 218491007682 Signal peptide predicted for ECA1510 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.918 between residues 22 and 23; signal peptide 218491007683 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 218491007684 8 probable transmembrane helices predicted for ECA1510 by TMHMM2.0 at aa 13-35, 388-410, 423-442, 452-471, 491-508, 528-550, 563-585 and 615-632 218491007685 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007686 HMMPfam hit to PF03239, DE Iron permease FTR1 family, score 3.1e-104 218491007687 Signal peptide predicted for ECA1511 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.706 between residues 24 and 25; signal peptide 218491007688 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 218491007689 Predicted membrane protein [Function unknown]; Region: COG4393 218491007690 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 218491007691 Uncharacterized conserved protein [Function unknown]; Region: COG3350 218491007692 8 probable transmembrane helices predicted for ECA1512 by TMHMM2.0 at aa 4-23, 30-52, 57-79, 84-101, 121-143, 152-174, 198-220 and 244-266 218491007693 Signal peptide predicted for ECA1513 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.887 between residues 36 and 37; signal peptide 218491007694 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218491007695 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 218491007696 FtsX-like permease family; Region: FtsX; pfam02687 218491007697 4 probable transmembrane helices predicted for ECA1513 by TMHMM2.0 at aa 20-42, 302-324, 353-375 and 390-412 218491007698 HMMPfam hit to PF02687, DE Predicted permease, score 1e-36 218491007699 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491007700 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 218491007701 Signal peptide predicted for ECA1514 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.549 between residues 38 and 39; signal peptide 218491007702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218491007703 FtsX-like permease family; Region: FtsX; pfam02687 218491007704 4 probable transmembrane helices predicted for ECA1514 by TMHMM2.0 at aa 17-39, 249-271, 299-321 and 331-353 218491007705 HMMPfam hit to PF02687, DE Predicted permease, score 2e-28 218491007706 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218491007707 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218491007708 Walker A/P-loop; other site 218491007709 ATP binding site [chemical binding]; other site 218491007710 Q-loop/lid; other site 218491007711 ABC transporter signature motif; other site 218491007712 Walker B; other site 218491007713 D-loop; other site 218491007714 H-loop/switch region; other site 218491007715 HMMPfam hit to PF00005, DE ABC transporter, score 3.7e-62 218491007716 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007717 PS00211 ABC transporters family signature. 218491007718 Signal peptide predicted for ECA1516 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.279 between residues 22 and 23; signal peptide 218491007719 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 218491007720 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218491007721 catalytic residues [active] 218491007722 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007723 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218491007724 Signal peptide predicted for ECA1517 by SignalP 2.0 HMM (Signal peptide probabilty 0.827) with cleavage site probability 0.335 between residues 20 and 21; signal peptide 218491007725 EamA-like transporter family; Region: EamA; pfam00892 218491007726 10 probable transmembrane helices predicted for ECA1517 by TMHMM2.0 at aa 2-24, 34-51, 64-86, 91-113, 125-143, 153-175, 195-217, 232-252, 259-281 and 286-308 218491007727 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 0.041 218491007728 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 2.5e-05 218491007729 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491007730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491007731 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491007732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491007733 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.0025 218491007734 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 3.8e-08 218491007735 Predicted helix-turn-helix motif with score 1352.000, SD 3.79 at aa 188-209, sequence ITLKELAALVSLSPYHFLRQFK 218491007736 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 218491007737 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 218491007738 substrate binding site [chemical binding]; other site 218491007739 dimerization interface [polypeptide binding]; other site 218491007740 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.6e-15 218491007741 Predicted helix-turn-helix motif with score 1655.000, SD 4.82 at aa 17-38, sequence YNLTEVANTLFTSQSGVSRHIR 218491007742 PS00044 Bacterial regulatory proteins, lysR family signature. 218491007743 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 8e-45 218491007744 Signal peptide predicted for ECA1520 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.387 between residues 25 and 26; signal peptide 218491007745 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 218491007746 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218491007747 HMMPfam hit to PF00375, DE Sodium:dicarboxylate symporter family, score 1.2e-210 218491007748 7 probable transmembrane helices predicted for ECA1520 by TMHMM2.0 at aa 10-28, 49-71, 86-108, 208-230, 235-257, 328-350 and 365-387 218491007749 PS00713 Sodium:dicarboxylate symporter family signature 1. 218491007750 PS00714 Sodium:dicarboxylate symporter family signature 2. 218491007751 Chalcone and stilbene synthases, N-terminal domain; Region: Chal_sti_synt_N; pfam00195 218491007752 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007753 Signal peptide predicted for ECA1522 by SignalP 2.0 HMM (Signal peptide probabilty 0.808) with cleavage site probability 0.650 between residues 37 and 38; signal peptide 218491007754 2 probable transmembrane helices predicted for ECA1522 by TMHMM2.0 at aa 7-29 and 67-86 218491007755 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 218491007756 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 218491007757 putative active site [active] 218491007758 metal binding site [ion binding]; metal-binding site 218491007759 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 6.9e-11 218491007760 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491007761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007762 putative PBP binding loops; other site 218491007763 dimer interface [polypeptide binding]; other site 218491007764 ABC-ATPase subunit interface; other site 218491007765 7 probable transmembrane helices predicted for ECA1524 by TMHMM2.0 at aa 42-59, 93-115, 122-144, 154-176, 189-211, 221-243 and 254-276 218491007766 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0047 218491007767 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491007768 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491007769 Walker A/P-loop; other site 218491007770 ATP binding site [chemical binding]; other site 218491007771 Q-loop/lid; other site 218491007772 ABC transporter signature motif; other site 218491007773 Walker B; other site 218491007774 D-loop; other site 218491007775 H-loop/switch region; other site 218491007776 HMMPfam hit to PF00005, DE ABC transporter, score 2.6e-56 218491007777 PS00211 ABC transporters family signature. 218491007778 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007779 Signal peptide predicted for ECA1526 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 31 and 32; signal peptide 218491007780 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 218491007781 NMT1-like family; Region: NMT1_2; pfam13379 218491007782 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 218491007783 HMMPfam hit to PF02615, DE Malate/L-lactate dehydrogenase, score 6.1e-84 218491007784 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007785 Signal peptide predicted for ECA1528 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23; signal peptide 218491007786 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 218491007787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491007788 substrate binding pocket [chemical binding]; other site 218491007789 membrane-bound complex binding site; other site 218491007790 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491007791 Signal peptide predicted for ECA1529 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.550 between residues 26 and 27; signal peptide 218491007792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007793 dimer interface [polypeptide binding]; other site 218491007794 conserved gate region; other site 218491007795 putative PBP binding loops; other site 218491007796 ABC-ATPase subunit interface; other site 218491007797 6 probable transmembrane helices predicted for ECA1529 by TMHMM2.0 at aa 7-26, 67-89, 101-123, 128-147, 191-213 and 223-245 218491007798 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4e-09 218491007799 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491007800 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491007801 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491007802 Walker A/P-loop; other site 218491007803 ATP binding site [chemical binding]; other site 218491007804 Q-loop/lid; other site 218491007805 ABC transporter signature motif; other site 218491007806 Walker B; other site 218491007807 D-loop; other site 218491007808 H-loop/switch region; other site 218491007809 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-64 218491007810 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007811 PS00211 ABC transporters family signature. 218491007812 D-cysteine desulfhydrase; Validated; Region: PRK03910 218491007813 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 218491007814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491007815 catalytic residue [active] 218491007816 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 4.7e-06 218491007817 aspartate racemase; Region: asp_race; TIGR00035 218491007818 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 218491007819 HMMPfam hit to PF01177, DE Asp/Glu/Hydantoin racemase, score 7.4e-08 218491007820 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 218491007821 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 218491007822 11 probable transmembrane helices predicted for ECA1533 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 142-164, 171-193, 236-255, 267-289, 304-326, 333-355, 359-381 and 421-443 218491007823 HMMPfam hit to PF03605, DE Anaerobic c4-dicarboxylate membrane transporter, score 3.6e-249 218491007824 Signal peptide predicted for ECA1534 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.808 between residues 37 and 38; signal peptide 218491007825 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 218491007826 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 9.1e-41 218491007827 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 6.2e-41 218491007828 1 probable transmembrane helix predicted for ECA1534 by TMHMM2.0 at aa 12-34 218491007829 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218491007830 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491007831 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491007832 PS00543 HlyD family secretion proteins signature. 218491007833 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 3.2e-57 218491007834 1 probable transmembrane helix predicted for ECA1535 by TMHMM2.0 at aa 39-56 218491007835 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 218491007836 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 218491007837 Walker A/P-loop; other site 218491007838 ATP binding site [chemical binding]; other site 218491007839 Q-loop/lid; other site 218491007840 ABC transporter signature motif; other site 218491007841 Walker B; other site 218491007842 D-loop; other site 218491007843 H-loop/switch region; other site 218491007844 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-57 218491007845 PS00211 ABC transporters family signature. 218491007846 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007847 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 0.00026 218491007848 5 probable transmembrane helices predicted for ECA1536 by TMHMM2.0 at aa 34-56, 66-88, 143-165, 169-186 and 267-289 218491007849 Heme-binding protein A (HasA); Region: HasA; pfam06438 218491007850 Signal peptide predicted for ECA1538 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 37 and 38; signal peptide 218491007851 Secretin and TonB N terminus short domain; Region: STN; smart00965 218491007852 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 218491007853 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491007854 N-terminal plug; other site 218491007855 ligand-binding site [chemical binding]; other site 218491007856 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 8.1e-05 218491007857 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491007858 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 218491007859 FecR protein; Region: FecR; pfam04773 218491007860 1 probable transmembrane helix predicted for ECA1539 by TMHMM2.0 at aa 93-115 218491007861 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 218491007862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491007863 Predicted helix-turn-helix motif with score 1768.000, SD 5.21 at aa 136-157, sequence MTQAQIAQQLAISLSTVEKHLA 218491007864 HMMPfam hit to PF00776, , score 0.0012 218491007865 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 218491007866 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 218491007867 tetrameric interface [polypeptide binding]; other site 218491007868 NAD binding site [chemical binding]; other site 218491007869 catalytic residues [active] 218491007870 substrate binding site [chemical binding]; other site 218491007871 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 3.9e-177 218491007872 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491007873 putrescine aminotransferase; Region: putres_am_tran; TIGR03372 218491007874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491007875 inhibitor-cofactor binding pocket; inhibition site 218491007876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491007877 catalytic residue [active] 218491007878 HMMPfam hit to PF00202, DE Aminotransferase class-III, score 4.6e-174 218491007879 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491007880 Methyltransferase domain; Region: Methyltransf_23; pfam13489 218491007881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491007882 S-adenosylmethionine binding site [chemical binding]; other site 218491007883 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491007884 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.7e-05 218491007885 Predicted helix-turn-helix motif with score 1068.000, SD 2.82 at aa 227-248, sequence LTLACIAAQSGMSESKLKLGFH 218491007886 PS00041 Bacterial regulatory proteins, araC family signature. 218491007887 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.63 218491007888 proline/glycine betaine transporter; Provisional; Region: PRK10642 218491007889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491007890 putative substrate translocation pore; other site 218491007891 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 218491007892 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 2.3e-82 218491007893 12 probable transmembrane helices predicted for ECA1546 by TMHMM2.0 at aa 27-49, 64-86, 99-118, 122-144, 164-186, 201-218, 261-283, 298-320, 327-347, 352-374, 387-409 and 419-438 218491007894 PS00216 Sugar transport proteins signature 1. 218491007895 AMP nucleosidase; Provisional; Region: PRK08292 218491007896 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 218491007897 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 218491007898 HMMPfam hit to PF01048, DE Phosphorylase family, score 9e-80 218491007899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491007900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218491007901 11 probable transmembrane helices predicted for ECA1548 by TMHMM2.0 at aa 21-43, 117-139, 159-181, 191-213, 250-272, 301-323, 344-366, 409-431, 444-466, 519-541 and 562-584 218491007902 Signal peptide predicted for ECA1549 by SignalP 2.0 HMM (Signal peptide probabilty 0.934) with cleavage site probability 0.895 between residues 25 and 26; signal peptide 218491007903 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 218491007904 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 218491007905 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 1.7e-16 218491007906 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491007908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491007909 putative substrate translocation pore; other site 218491007910 12 probable transmembrane helices predicted for ECA1550 by TMHMM2.0 at aa 16-38, 48-70, 75-97, 101-123, 144-166, 171-193, 218-237, 252-271, 283-302, 312-334, 346-368 and 383-405 218491007911 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 218491007912 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491007913 Walker A/P-loop; other site 218491007914 ATP binding site [chemical binding]; other site 218491007915 Q-loop/lid; other site 218491007916 ABC transporter signature motif; other site 218491007917 Walker B; other site 218491007918 D-loop; other site 218491007919 H-loop/switch region; other site 218491007920 HMMPfam hit to PF00005, DE ABC transporter, score 2e-55 218491007921 PS00211 ABC transporters family signature. 218491007922 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007923 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 218491007924 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491007925 Walker A/P-loop; other site 218491007926 ATP binding site [chemical binding]; other site 218491007927 Q-loop/lid; other site 218491007928 ABC transporter signature motif; other site 218491007929 Walker B; other site 218491007930 D-loop; other site 218491007931 H-loop/switch region; other site 218491007932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491007933 HMMPfam hit to PF00005, DE ABC transporter, score 1.5e-41 218491007934 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007935 hypothetical protein; Provisional; Region: PRK09956 218491007936 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218491007937 catalytic residues [active] 218491007938 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491007939 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491007940 Walker A/P-loop; other site 218491007941 ATP binding site [chemical binding]; other site 218491007942 Q-loop/lid; other site 218491007943 ABC transporter signature motif; other site 218491007944 Walker B; other site 218491007945 D-loop; other site 218491007946 H-loop/switch region; other site 218491007947 HMMPfam hit to PF00005, DE ABC transporter, score 5e-65 218491007948 PS00211 ABC transporters family signature. 218491007949 PS00017 ATP/GTP-binding site motif A (P-loop). 218491007950 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491007951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491007952 dimer interface [polypeptide binding]; other site 218491007953 conserved gate region; other site 218491007954 putative PBP binding loops; other site 218491007955 ABC-ATPase subunit interface; other site 218491007956 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491007957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218491007958 10 probable transmembrane helices predicted for ECA1557 by TMHMM2.0 at aa 19-41, 77-99, 112-134, 205-227, 234-256, 336-358, 365-387, 397-416, 440-462 and 491-513 218491007959 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0061 218491007960 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.5e-07 218491007961 Signal peptide predicted for ECA1558 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.984 between residues 40 and 41; signal peptide 218491007962 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 218491007963 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 218491007964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491007965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491007966 LysR substrate binding domain; Region: LysR_substrate; pfam03466 218491007967 dimerization interface [polypeptide binding]; other site 218491007968 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.8e-24 218491007969 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 4.5e-20 218491007970 PS00044 Bacterial regulatory proteins, lysR family signature. 218491007971 Predicted helix-turn-helix motif with score 1529.000, SD 4.39 at aa 18-39, sequence GSFVQAAEAVCLSQSAFSRSIQ 218491007972 Signal peptide predicted for ECA1560 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.718 between residues 19 and 20; signal peptide 218491007973 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 218491007974 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02611, DE CDP-diacylglycerol pyrophosphatase, score 2.6e-70 218491007975 1 probable transmembrane helix predicted for ECA1560 by TMHMM2.0 at aa 7-25 218491007976 transcriptional regulator TraR; Provisional; Region: PRK13870 218491007977 Autoinducer binding domain; Region: Autoind_bind; pfam03472 218491007978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491007979 DNA binding residues [nucleotide binding] 218491007980 dimerization interface [polypeptide binding]; other site 218491007981 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 1.5e-09 218491007982 PS00622 Bacterial regulatory proteins, luxR family signature. 218491007983 Predicted helix-turn-helix motif with score 1095.000, SD 2.92 at aa 195-216, sequence KTYPEIALILDIKISTVKFHIG 218491007984 HMMPfam hit to PF03472, DE Autoinducer binding domain, score 3.9e-61 218491007985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491007986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491007987 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 218491007988 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 1.1e-15 218491007989 Predicted helix-turn-helix motif with score 1405.000, SD 3.97 at aa 28-49, sequence ATMNELAKRVGGSKATLYGYFS 218491007990 Signal peptide predicted for ECA1563 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.303 between residues 20 and 21; signal peptide 218491007991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 218491007992 Protein of unknown function (DUF330); Region: DUF330; pfam03886 218491007993 HMMPfam hit to PF03886, DE Protein of unknown function (DUF330), score 8e-05 218491007994 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491007995 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 218491007996 mce related protein; Region: MCE; pfam02470 218491007997 mce related protein; Region: MCE; pfam02470 218491007998 mce related protein; Region: MCE; pfam02470 218491007999 1 probable transmembrane helix predicted for ECA1564 by TMHMM2.0 at aa 20-42 218491008000 Paraquat-inducible protein A; Region: PqiA; pfam04403 218491008001 4 probable transmembrane helices predicted for ECA1565 by TMHMM2.0 at aa 50-72, 103-125, 146-168 and 178-196 218491008002 Paraquat-inducible protein A; Region: PqiA; pfam04403 218491008003 4 probable transmembrane helices predicted for ECA1566 by TMHMM2.0 at aa 45-67, 100-122, 142-164 and 169-191 218491008004 Signal peptide predicted for ECA1567 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.556 between residues 40 and 41; signal peptide 218491008005 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 218491008006 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008007 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 218491008008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491008009 Response regulator receiver domain; Region: Response_reg; pfam00072 218491008010 active site 218491008011 phosphorylation site [posttranslational modification] 218491008012 intermolecular recognition site; other site 218491008013 dimerization interface [polypeptide binding]; other site 218491008014 HMMPfam hit to PF01584, DE CheW-like domain, score 5.1e-24 218491008015 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.2e-12 218491008016 putative S-transferase; Provisional; Region: PRK11752 218491008017 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 218491008018 C-terminal domain interface [polypeptide binding]; other site 218491008019 GSH binding site (G-site) [chemical binding]; other site 218491008020 dimer interface [polypeptide binding]; other site 218491008021 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 218491008022 dimer interface [polypeptide binding]; other site 218491008023 N-terminal domain interface [polypeptide binding]; other site 218491008024 active site 218491008025 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491008026 hypothetical protein; Provisional; Region: PRK06815 218491008027 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218491008028 tetramer interface [polypeptide binding]; other site 218491008029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491008030 catalytic residue [active] 218491008031 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 7.8e-53 218491008032 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218491008033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491008034 dimerization interface [polypeptide binding]; other site 218491008035 putative DNA binding site [nucleotide binding]; other site 218491008036 putative Zn2+ binding site [ion binding]; other site 218491008037 HMMPfam hit to PF01022, DE Bacterial regulatory protein, arsR family, score 8.9e-09 218491008038 Signal peptide predicted for ECA1573 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.536 between residues 30 and 31; signal peptide 218491008039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491008040 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 218491008041 putative substrate translocation pore; other site 218491008042 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00027 218491008043 12 probable transmembrane helices predicted for ECA1573 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 104-126, 138-160, 165-187, 225-247, 252-269, 282-301, 305-327, 340-362 and 372-394 218491008044 Signal peptide predicted for ECA1574 by SignalP 2.0 HMM (Signal peptide probabilty 0.731) with cleavage site probability 0.164 between residues 42 and 43; signal peptide 218491008045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491008046 putative substrate translocation pore; other site 218491008047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491008048 12 probable transmembrane helices predicted for ECA1574 by TMHMM2.0 at aa 20-42, 47-69, 82-104, 109-128, 141-163, 173-195, 216-238, 248-267, 274-296, 300-319, 345-367 and 382-404 218491008049 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00026 218491008050 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 218491008051 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 218491008052 DNA binding residues [nucleotide binding] 218491008053 putative dimer interface [polypeptide binding]; other site 218491008054 putative metal binding residues [ion binding]; other site 218491008055 Predicted helix-turn-helix motif with score 1157.000, SD 3.13 at aa 8-29, sequence LDIGDVSEKSGIKPSALRYYED 218491008056 HMMPfam hit to PF00376, DE MerR family regulatory protein, score 1.1e-05 218491008057 PS00552 Bacterial regulatory proteins, merR family signature. 218491008058 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 218491008059 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491008060 1 probable transmembrane helix predicted for ECA1577 by TMHMM2.0 at aa 5-27 218491008061 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 218491008063 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 218491008064 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 218491008065 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 218491008066 HMMPfam hit to PF02558, DE Ketopantoate reductase PanE/ApbA, score 2.8e-44 218491008067 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218491008068 DNA-binding site [nucleotide binding]; DNA binding site 218491008069 RNA-binding motif; other site 218491008070 HMMPfam hit to PF00313, DE 'Cold-shock' DNA-binding domain, score 0.00014 218491008071 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 218491008072 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 218491008073 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 218491008074 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 218491008075 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 218491008076 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 218491008077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491008078 NAD(P) binding site [chemical binding]; other site 218491008079 active site 218491008080 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 5.2e-50 218491008081 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218491008082 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 218491008083 C-terminal domain interface [polypeptide binding]; other site 218491008084 GSH binding site (G-site) [chemical binding]; other site 218491008085 dimer interface [polypeptide binding]; other site 218491008086 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 218491008087 N-terminal domain interface [polypeptide binding]; other site 218491008088 dimer interface [polypeptide binding]; other site 218491008089 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 2e-10 218491008090 HMMPfam hit to PF00043, DE Glutathione S-transferase, C-terminal domain, score 3.2e-08 218491008091 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 218491008092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491008093 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 218491008094 ATP binding site [chemical binding]; other site 218491008095 putative Mg++ binding site [ion binding]; other site 218491008096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491008097 nucleotide binding region [chemical binding]; other site 218491008098 ATP-binding site [chemical binding]; other site 218491008099 DEAD/H associated; Region: DEAD_assoc; pfam08494 218491008100 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 6.7e-15 218491008101 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 1.8e-37 218491008102 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491008103 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008104 TfoX N-terminal domain; Region: TfoX_N; pfam04993 218491008105 Protein of unknown function (DUF419); Region: DUF419; pfam04237 218491008106 Protein of unknown function (DUF419); Region: DUF419; pfam04237 218491008107 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 218491008108 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 218491008109 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491008110 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218491008111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491008112 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.1e-06 218491008113 SnoaL-like domain; Region: SnoaL_3; pfam13474 218491008114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 218491008115 Domain of unknown function DUF87; Region: DUF87; pfam01935 218491008116 HerA helicase [Replication, recombination, and repair]; Region: COG0433 218491008117 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008118 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 218491008119 integrated plasmid 218491008120 SIR2-like domain; Region: SIR2_2; pfam13289 218491008121 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 218491008122 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 218491008123 Protein of unknown function, DUF462; Region: DUF462; cl01190 218491008124 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491008125 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 218491008126 Integrase core domain; Region: rve; pfam00665 218491008127 HMMPfam hit to PF00665, DE Integrase core domain, score 8.6e-27 218491008128 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 218491008129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491008130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491008131 dimerization interface [polypeptide binding]; other site 218491008132 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 7.2e-18 218491008133 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 5.3e-22 218491008134 PS00044 Bacterial regulatory proteins, lysR family signature. 218491008135 Predicted helix-turn-helix motif with score 1620.000, SD 4.70 at aa 21-42, sequence GNFARAAEELSLTEGAISRQIA 218491008136 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 218491008137 ArsC family; Region: ArsC; pfam03960 218491008138 catalytic residues [active] 218491008139 HMMPfam hit to PF03960, DE ArsC family, score 4.5e-31 218491008140 arsenical pump membrane protein; Provisional; Region: PRK15445 218491008141 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 218491008142 transmembrane helices; other site 218491008143 HMMPfam hit to PF02040, DE Arsenical pump membrane protein, score 0 218491008144 11 probable transmembrane helices predicted for ECA1604 by TMHMM2.0 at aa 7-28, 48-70, 91-110, 114-131, 138-160, 175-197, 224-241, 245-262, 274-296, 316-335 and 401-423 218491008145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491008146 dimerization interface [polypeptide binding]; other site 218491008147 putative DNA binding site [nucleotide binding]; other site 218491008148 putative Zn2+ binding site [ion binding]; other site 218491008149 HMMPfam hit to PF01022, DE Bacterial regulatory protein, arsR family, score 6.8e-31 218491008150 PS00846 Bacterial regulatory proteins, arsR family signature. 218491008151 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 218491008152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218491008153 HMMPfam hit to PF03358, DE NADPH-dependent FMN reductase, score 3.4e-65 218491008154 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 218491008155 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008156 3 probable transmembrane helices predicted for ECA1609 by TMHMM2.0 at aa 12-34, 69-91 and 103-125 218491008157 Signal peptide predicted for ECA1612 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.987 between residues 23 and 24; signal peptide 218491008158 TrbM; Region: TrbM; pfam07424 218491008159 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 218491008160 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 218491008161 Walker A motif; other site 218491008162 hexamer interface [polypeptide binding]; other site 218491008163 ATP binding site [chemical binding]; other site 218491008164 Walker B motif; other site 218491008165 HMMPfam hit to PF00437, DE Type II/IV secretion system protein, score 3.3e-06 218491008166 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491008167 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008168 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 218491008169 HMMPfam hit to PF03743, DE Bacterial conjugation TrbI-like protein, score 6.9e-63 218491008170 1 probable transmembrane helix predicted for ECA1614 by TMHMM2.0 at aa 57-74 218491008171 Signal peptide predicted for ECA1615 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21; signal peptide 218491008172 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 218491008173 VirB7 interaction site; other site 218491008174 1 probable transmembrane helix predicted for ECA1615 by TMHMM2.0 at aa 5-23 218491008175 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008176 Signal peptide predicted for ECA1616 by SignalP 2.0 HMM (Signal peptide probabilty 0.620) with cleavage site probability 0.609 between residues 45 and 46; signal peptide 218491008177 VirB8 protein; Region: VirB8; pfam04335 218491008178 1 probable transmembrane helix predicted for ECA1616 by TMHMM2.0 at aa 29-51 218491008179 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 218491008180 7 probable transmembrane helices predicted for ECA1617 by TMHMM2.0 at aa 27-49, 134-156, 161-183, 190-212, 232-251, 258-280 and 295-317 218491008181 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008182 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 218491008183 Signal peptide predicted for ECA1619 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.885 between residues 20 and 21; signal peptide 218491008184 Type IV secretion system proteins; Region: T4SS; pfam07996 218491008185 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 218491008186 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 218491008187 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 218491008188 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008189 HMMPfam hit to PF03135, DE CagE, TrbE, VirB family, component of type IV transporter system, score 8.4e-48 218491008190 1 probable transmembrane helix predicted for ECA1620 by TMHMM2.0 at aa 13-35 218491008191 TrbC/VIRB2 family; Region: TrbC; pfam04956 218491008192 Signal peptide predicted for ECA1621 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 22 and 23; signal peptide 218491008193 2 probable transmembrane helices predicted for ECA1621 by TMHMM2.0 at aa 39-58 and 73-90 218491008194 Signal peptide predicted for ECA1622 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 23 and 24; signal peptide 218491008195 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491008196 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491008197 catalytic residue [active] 218491008198 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 1.4e-06 218491008199 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 218491008200 HMMPfam hit to PF01258, DE Prokaryotic dksA/traR C4-type zinc finger, score 3.9e-18 218491008201 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 218491008202 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 218491008203 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 7-28, sequence LRLKQVEVKTGLKRSQVYLYMK 218491008204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491008205 Helix-turn-helix domain; Region: HTH_18; pfam12833 218491008206 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.0005 218491008207 Pseudogene. This CDS appears to have a frameshift mutation around codon 74. Similar to Escherichia coli integrase Int SWALL:Q9RM39 (EMBL:AJ245584) (420 aa) fasta scores: E(): 4.9e-138, 77.14% id in 420 aa, and to Yersinia pseudotuberculosis integrase Int SWALL:Q9ZEX4 (EMBL:AJ009592) (420 aa) fasta scores: E(): 5.7e-138, 77.14% id in 420 aa;integrase (pseudogene) 218491008208 HMMPfam hit to PF00589, DE Phage integrase family, score 1.7e-37 218491008209 Low %GC genomic island 218491008210 PS00018 EF-hand calcium-binding domain. 218491008211 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 218491008212 PLD-like domain; Region: PLDc_2; pfam13091 218491008213 homodimer interface [polypeptide binding]; other site 218491008214 putative active site [active] 218491008215 catalytic site [active] 218491008216 PS00037 Myb DNA-binding domain repeat signature 1. 218491008217 2 probable transmembrane helices predicted for ECA1642 by TMHMM2.0 at aa 32-51 and 58-80 218491008218 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218491008219 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 81-113, sequence LEYMEFGNLINLSQSSLCKALNIASGNMSNIFK 218491008220 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 92-113, sequence LSQSSLCKALNIASGNMSNIFK 218491008221 Predicted helix-turn-helix motif with score 1224.000, SD 3.36 at aa 81-102, sequence LEYMEFGNLINLSQSSLCKALN 218491008222 Signal peptide predicted for ECA1648 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.503 between residues 23 and 24; signal peptide 218491008223 Signal peptide predicted for ECA1649 by SignalP 2.0 HMM (Signal peptide probabilty 0.634) with cleavage site probability 0.616 between residues 27 and 28; signal peptide 218491008224 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 218491008225 Integrase core domain; Region: rve; pfam00665 218491008226 Integrase core domain; Region: rve_3; pfam13683 218491008227 HMMPfam hit to PF00665, DE Integrase core domain, score 3.2e-35 218491008228 Transposase; Region: HTH_Tnp_1; pfam01527 218491008229 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01527, DE Transposase, score 2e-35 218491008230 Predicted helix-turn-helix motif with score 1294.000, SD 3.59 at aa 22-43, sequence RHVKDVCRENGVSEASYYNWKS 218491008231 Signal peptide predicted for ECA1654 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.415 between residues 21 and 22; signal peptide 218491008232 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 218491008233 Signal peptide predicted for ECA1655 by SignalP 2.0 HMM (Signal peptide probabilty 0.843) with cleavage site probability 0.344 between residues 20 and 21; signal peptide 218491008234 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008235 2 probable transmembrane helices predicted for ECA1656 by TMHMM2.0 at aa 33-55 and 59-81 218491008236 MobA/MobL family; Region: MobA_MobL; pfam03389 218491008237 HMMPfam hit to PF03389, DE MobA/MobL family, score 2.1e-44 218491008238 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 218491008239 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 218491008240 Conjugal transfer protein TraD; Region: TraD; pfam06412 218491008241 Signal peptide predicted for ECA1664 by SignalP 2.0 HMM (Signal peptide probabilty 0.959) with cleavage site probability 0.860 between residues 21 and 22; signal peptide 218491008242 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008243 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 218491008244 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 218491008245 HMMPfam hit to PF00816, DE H-NS histone family, score 2.1e-63 218491008246 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008247 Signal peptide predicted for ECA1667 by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.580 between residues 41 and 42; signal peptide 218491008248 PilS N terminal; Region: PilS; pfam08805 218491008249 PS00409 Prokaryotic N-terminal methylation site. 218491008250 1 probable transmembrane helix predicted for ECA1667 by TMHMM2.0 at aa 20-42 218491008251 Signal peptide predicted for ECA1668 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.427 between residues 25 and 26; signal peptide 218491008252 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 218491008253 PS00409 Prokaryotic N-terminal methylation site. 218491008254 1 probable transmembrane helix predicted for ECA1668 by TMHMM2.0 at aa 9-26 218491008255 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491008256 PAAR motif; Region: PAAR_motif; pfam05488 218491008257 S-type Pyocin; Region: Pyocin_S; pfam06958 218491008258 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 218491008259 Signal peptide predicted for ECA1670 by SignalP 2.0 HMM (Signal peptide probabilty 0.912) with cleavage site probability 0.545 between residues 23 and 24; signal peptide 218491008260 4 probable transmembrane helices predicted for ECA1670 by TMHMM2.0 at aa 4-22, 34-51, 83-105 and 134-156 218491008261 1 probable transmembrane helix predicted for ECA1671 by TMHMM2.0 at aa 4-26 218491008262 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491008263 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491008264 1 probable transmembrane helix predicted for ECA1675 by TMHMM2.0 at aa 29-51 218491008265 toxin MazF; Provisional; Region: PRK09907 218491008266 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02452, DE PemK-like protein, score 5.3e-36 218491008267 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 218491008268 integrase; Provisional; Region: PRK09692 218491008269 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491008270 active site 218491008271 Int/Topo IB signature motif; other site 218491008272 HMMPfam hit to PF00589, DE Phage integrase family, score 6e-34 218491008273 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 218491008274 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491008275 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 218491008276 heme-binding site [chemical binding]; other site 218491008277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491008278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491008279 metal binding site [ion binding]; metal-binding site 218491008280 active site 218491008281 I-site; other site 218491008282 HMMPfam hit to PF00990, DE GGDEF domain, score 9.6e-58 218491008283 hypothetical protein; Provisional; Region: PRK10708 218491008284 Tar ligand binding domain homologue; Region: TarH; pfam02203 218491008285 ligand binding site [chemical binding]; other site 218491008286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491008287 dimerization interface [polypeptide binding]; other site 218491008288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491008289 dimer interface [polypeptide binding]; other site 218491008290 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 218491008291 putative CheW interface [polypeptide binding]; other site 218491008292 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.3e-113 218491008293 PS00538 Bacterial chemotaxis sensory transducers signature. 218491008294 HMMPfam hit to PF00672, DE HAMP domain, score 4.2e-13 218491008295 2 probable transmembrane helices predicted for ECA1683 by TMHMM2.0 at aa 27-49 and 204-226 218491008296 HMMPfam hit to PF02203, DE Tar ligand binding domain homologue, score 7.2e-06 218491008297 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218491008298 EamA-like transporter family; Region: EamA; pfam00892 218491008299 EamA-like transporter family; Region: EamA; pfam00892 218491008300 10 probable transmembrane helices predicted for ECA1684 by TMHMM2.0 at aa 23-42, 62-84, 97-119, 124-141, 148-166, 170-192, 212-234, 239-261, 266-288 and 298-315 218491008301 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 7.6e-13 218491008302 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 1.2e-18 218491008303 transcriptional activator FlhD; Provisional; Region: PRK02909 218491008304 transcriptional activator FlhC; Provisional; Region: PRK12722 218491008305 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 218491008306 flagellar motor protein MotA; Validated; Region: PRK09110 218491008307 Signal peptide predicted for ECA1687 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.586 between residues 26 and 27; signal peptide 218491008308 4 probable transmembrane helices predicted for ECA1687 by TMHMM2.0 at aa 7-29, 34-51, 171-190 and 205-227 218491008309 PS01307 Flagellar motor protein motA family signature. 218491008310 flagellar motor protein MotB; Validated; Region: motB; PRK09041 218491008311 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 218491008312 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218491008313 ligand binding site [chemical binding]; other site 218491008314 1 probable transmembrane helix predicted for ECA1688 by TMHMM2.0 at aa 21-43 218491008315 HMMPfam hit to PF00691, DE OmpA family, score 9.1e-23 218491008316 chemotaxis protein CheA; Provisional; Region: PRK10547 218491008317 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218491008318 putative binding surface; other site 218491008319 active site 218491008320 CheY binding; Region: CheY-binding; pfam09078 218491008321 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 218491008322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491008323 ATP binding site [chemical binding]; other site 218491008324 Mg2+ binding site [ion binding]; other site 218491008325 G-X-G motif; other site 218491008326 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 218491008327 HMMPfam hit to PF01627, DE Hpt domain, score 1.5e-41 218491008328 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491008329 HMMPfam hit to PF02895, DE Signal transducing histidine kinase, homodimeric domain, score 2.6e-26 218491008330 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.6e-25 218491008331 HMMPfam hit to PF01584, DE CheW-like domain, score 1.4e-32 218491008332 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 218491008333 putative CheA interaction surface; other site 218491008334 HMMPfam hit to PF01584, DE CheW-like domain, score 2.1e-51 218491008335 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 218491008336 Signal peptide predicted for ECA1691 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.617 between residues 34 and 35; signal peptide 218491008337 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218491008338 dimer interface [polypeptide binding]; other site 218491008339 ligand binding site [chemical binding]; other site 218491008340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491008341 dimerization interface [polypeptide binding]; other site 218491008342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491008343 dimer interface [polypeptide binding]; other site 218491008344 putative CheW interface [polypeptide binding]; other site 218491008345 2 probable transmembrane helices predicted for ECA1691 by TMHMM2.0 at aa 10-32 and 192-214 218491008346 HMMPfam hit to PF02203, DE Tar ligand binding domain homologue, score 2.9e-27 218491008347 HMMPfam hit to PF00672, DE HAMP domain, score 1.2e-06 218491008348 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 9.3e-120 218491008349 PS00538 Bacterial chemotaxis sensory transducers signature. 218491008350 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 218491008351 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 218491008352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491008353 HMMPfam hit to PF03705, DE CheR methyltransferase, all-alpha domain, score 1.6e-21 218491008354 HMMPfam hit to PF01739, DE CheR methyltransferase, SAM binding domain, score 3.4e-82 218491008355 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 218491008356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491008357 active site 218491008358 phosphorylation site [posttranslational modification] 218491008359 intermolecular recognition site; other site 218491008360 dimerization interface [polypeptide binding]; other site 218491008361 CheB methylesterase; Region: CheB_methylest; pfam01339 218491008362 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.9e-33 218491008363 HMMPfam hit to PF01339, DE CheB methylesterase, score 1.4e-123 218491008364 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 218491008365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491008366 active site 218491008367 phosphorylation site [posttranslational modification] 218491008368 intermolecular recognition site; other site 218491008369 dimerization interface [polypeptide binding]; other site 218491008370 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 3.2e-42 218491008371 chemotaxis regulator CheZ; Provisional; Region: PRK11166 218491008372 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 218491008373 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 218491008374 HMMPfam hit to PF01312, DE FlhB HrpN YscU SpaS Family, score 7.3e-167 218491008375 4 probable transmembrane helices predicted for ECA1696 by TMHMM2.0 at aa 33-55, 94-116, 143-165 and 189-211 218491008376 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 218491008377 FHIPEP family; Region: FHIPEP; pfam00771 218491008378 7 probable transmembrane helices predicted for ECA1697 by TMHMM2.0 at aa 21-38, 42-64, 76-98, 113-135, 209-231, 251-273 and 293-315 218491008379 HMMPfam hit to PF00771, DE FHIPEP family, score 0 218491008380 PS00994 Bacterial export FHIPEP family signature. 218491008381 Signal peptide predicted for ECA1698 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.782 between residues 21 and 22; signal peptide 218491008382 Flagellar protein FlhE; Region: FlhE; pfam06366 218491008383 1 probable transmembrane helix predicted for ECA1698 by TMHMM2.0 at aa 7-26 218491008384 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 218491008385 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 218491008386 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 218491008387 Signal peptide predicted for ECA1701 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25; signal peptide 218491008388 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 218491008389 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 218491008390 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03240, DE FlgA family, score 2e-57 218491008391 1 probable transmembrane helix predicted for ECA1701 by TMHMM2.0 at aa 7-29 218491008392 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008393 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 218491008394 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 218491008395 HMMPfam hit to PF00460, DE Flagella basal body rod protein, score 1.6e-11 218491008396 PS00588 Flagella basal body rod proteins signature. 218491008397 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 218491008398 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218491008399 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218491008400 HMMPfam hit to PF00460, DE Flagella basal body rod protein, score 1.1e-09 218491008401 PS00588 Flagella basal body rod proteins signature. 218491008402 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633 218491008403 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 218491008404 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 218491008405 HMMPfam hit to PF03963, DE Flagellar hook capping protein, score 1.1e-42 218491008406 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 218491008407 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218491008408 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 218491008409 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218491008410 HMMPfam hit to PF00460, DE Flagella basal body rod protein, score 1.2e-11 218491008411 PS00588 Flagella basal body rod proteins signature. 218491008412 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 218491008413 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218491008414 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218491008415 HMMPfam hit to PF00460, DE Flagella basal body rod protein, score 8.8e-10 218491008416 PS00588 Flagella basal body rod proteins signature. 218491008417 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 218491008418 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 218491008419 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218491008420 HMMPfam hit to PF00460, DE Flagella basal body rod protein, score 1.8e-14 218491008421 PS00588 Flagella basal body rod proteins signature. 218491008422 Signal peptide predicted for ECA1708 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.478 between residues 44 and 45; signal peptide 218491008423 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 218491008424 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 218491008425 HMMPfam hit to PF02107, DE Flagellar L-ring protein, score 2.8e-86 218491008426 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 218491008427 Signal peptide predicted for ECA1709 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.994 between residues 23 and 24; signal peptide 218491008428 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 218491008429 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02119, DE Flagellar P-ring protein, score 5.1e-211 218491008430 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 218491008431 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 218491008432 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 218491008433 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491008434 HMMPfam hit to PF01832, DE Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 6.4e-61 218491008435 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 218491008436 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 218491008437 HMMPfam hit to PF00460, DE Flagella basal body rod protein, score 1.2e-06 218491008438 PS00588 Flagella basal body rod proteins signature. 218491008439 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 218491008440 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 218491008441 HMMPfam hit to PF00669, DE Bacterial flagellin N-terminus, score 2e-07 218491008442 1 probable transmembrane helix predicted for ECA1713 by TMHMM2.0 at aa 15-37 218491008443 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 218491008444 HMMPfam hit to PF01311, DE Bacterial export proteins, family 1, score 5.6e-103 218491008445 6 probable transmembrane helices predicted for ECA1714 by TMHMM2.0 at aa 15-34, 46-68, 73-95, 128-150, 179-201 and 214-236 218491008446 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 218491008447 Signal peptide predicted for ECA1715 by SignalP 2.0 HMM (Signal peptide probabilty 0.821) with cleavage site probability 0.800 between residues 40 and 41; signal peptide 218491008448 HMMPfam hit to PF01313, DE Bacterial export proteins, family 3, score 1e-41 218491008449 2 probable transmembrane helices predicted for ECA1715 by TMHMM2.0 at aa 16-38 and 48-70 218491008450 Signal peptide predicted for ECA1716 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.999 between residues 34 and 35; signal peptide 218491008451 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 218491008452 HMMPfam hit to PF00813, DE FliP family, score 8.5e-126 218491008453 5 probable transmembrane helices predicted for ECA1716 by TMHMM2.0 at aa 21-43, 58-80, 101-118, 198-220 and 227-249 218491008454 PS01061 Flagella transport protein fliP family signature 2. 218491008455 PS01060 Flagella transport protein fliP family signature 1. 218491008456 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 218491008457 1 probable transmembrane helix predicted for ECA1717 by TMHMM2.0 at aa 30-52 218491008458 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 218491008459 flagellar motor switch protein; Validated; Region: fliN; PRK05698 218491008460 HMMPfam hit to PF01052, DE Surface presentation of antigens (SPOA) protein, score 2.5e-35 218491008461 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 218491008462 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 218491008463 HMMPfam hit to PF02154, DE Flagellar motor switch protein FliM, score 4.9e-114 218491008464 Signal peptide predicted for ECA1720 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.265 between residues 34 and 35; signal peptide 218491008465 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 218491008466 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03748, DE Flagellar basal body-associated protein FliL, score 4.3e-33 218491008467 1 probable transmembrane helix predicted for ECA1720 by TMHMM2.0 at aa 16-38 218491008468 Signal peptide predicted for ECA1721 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.875 between residues 20 and 21; signal peptide 218491008469 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 218491008470 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 218491008471 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 218491008472 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 218491008473 HMMPfam hit to PF02050, DE Flagellar FliJ protein, score 1.1e-58 218491008474 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 218491008475 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 218491008476 Walker A motif/ATP binding site; other site 218491008477 Walker B motif; other site 218491008478 HMMPfam hit to PF00006, DE ATP synthase alpha/beta family, nucleotide-binding domain, score 4e-136 218491008479 PS00152 ATP synthase alpha and beta subunits signature. 218491008480 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008481 flagellar assembly protein H; Validated; Region: fliH; PRK05687 218491008482 Flagellar assembly protein FliH; Region: FliH; pfam02108 218491008483 HMMPfam hit to PF02108, DE Flagellar assembly protein FliH, score 4.7e-72 218491008484 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 218491008485 FliG C-terminal domain; Region: FliG_C; pfam01706 218491008486 HMMPfam hit to PF01706, DE FliG C-terminal domain, score 2.2e-58 218491008487 Signal peptide predicted for ECA1726 by SignalP 2.0 HMM (Signal peptide probabilty 0.939) with cleavage site probability 0.884 between residues 48 and 49; signal peptide 218491008488 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 218491008489 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 218491008490 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 218491008491 HMMPfam hit to PF01514, DE Secretory protein of YscJ/FliF family, score 1.8e-80 218491008492 1 probable transmembrane helix predicted for ECA1726 by TMHMM2.0 at aa 28-47 218491008493 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 218491008494 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02049, DE Flagellar hook-basal body complex protein FliE, score 1.2e-27 218491008495 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 218491008496 flagellar protein FliS; Validated; Region: fliS; PRK05685 218491008497 HMMPfam hit to PF02561, DE Flagellar protein FliS, score 7e-43 218491008498 flagellar capping protein; Reviewed; Region: fliD; PRK08032 218491008499 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 218491008500 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 218491008501 HMMPfam hit to PF02465, DE Flagellar hook-associated protein 2, score 4.5e-97 218491008502 flagellin; Provisional; Region: PRK12802 218491008503 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 218491008504 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 218491008505 HMMPfam hit to PF00669, DE Bacterial flagellin N-terminus, score 1.7e-65 218491008506 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008507 HMMPfam hit to PF00700, DE Bacterial flagellin C-terminus, score 3.5e-35 218491008508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491008509 S-adenosylmethionine binding site [chemical binding]; other site 218491008510 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 218491008511 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 218491008512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491008513 TPR motif; other site 218491008514 binding surface 218491008515 HMMPfam hit to PF00515, DE TPR Domain, score 31 218491008516 HMMPfam hit to PF00515, DE TPR Domain, score 0.012 218491008517 HMMPfam hit to PF00515, DE TPR Domain, score 0.0011 218491008518 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 218491008519 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218491008520 inhibitor-cofactor binding pocket; inhibition site 218491008521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491008522 catalytic residue [active] 218491008523 HMMPfam hit to PF01041, DE DegT/DnrJ/EryC1/StrS aminotransferase family, score 1.8e-102 218491008524 WbqC-like protein family; Region: WbqC; pfam08889 218491008525 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 218491008526 active site 218491008527 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 218491008528 active site 218491008529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491008530 Coenzyme A binding pocket [chemical binding]; other site 218491008531 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 7.4e-13 218491008532 Methyltransferase domain; Region: Methyltransf_23; pfam13489 218491008533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491008534 S-adenosylmethionine binding site [chemical binding]; other site 218491008535 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 218491008536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491008537 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218491008538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491008539 DNA binding residues [nucleotide binding] 218491008540 HMMPfam hit to PF00140, DE Sigma-70 factor, region 1.2, score 4.6e-84 218491008541 PS00715 Sigma-70 factors family signature 1. 218491008542 Predicted helix-turn-helix motif with score 1242.000, SD 3.42 at aa 205-226, sequence LNLKEIGAVLEVGESRVSQLHS 218491008543 PS00716 Sigma-70 factors family signature 2. 218491008544 flagellar regulatory protein FliZ; Region: FliZ; TIGR03823 218491008545 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 0.15 218491008546 hypothetical protein; Provisional; Region: PRK10536 218491008547 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02562, DE PhoH-like protein, score 4.5e-144 218491008548 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008549 hypothetical protein; Provisional; Region: PRK09273 218491008550 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 218491008551 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 218491008552 choline transport protein BetT; Provisional; Region: PRK09928 218491008553 HMMPfam hit to PF02028, DE BCCT family transporter, score 2.4e-282 218491008554 12 probable transmembrane helices predicted for ECA1743 by TMHMM2.0 at aa 13-35, 50-72, 93-115, 143-165, 194-216, 231-253, 260-279, 315-337, 350-369, 410-432, 452-474 and 478-500 218491008555 PS01303 BCCT family of transporters signature. 218491008556 transcriptional regulator BetI; Validated; Region: PRK00767 218491008557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491008558 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 218491008559 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 1.2e-11 218491008560 PS01081 Bacterial regulatory proteins, tetR family signature. 218491008561 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 30-51, sequence ASIVQIARRAGVSNGIISHYFR 218491008562 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491008563 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 218491008564 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 218491008565 tetrameric interface [polypeptide binding]; other site 218491008566 NAD binding site [chemical binding]; other site 218491008567 catalytic residues [active] 218491008568 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 1e-237 218491008569 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008570 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491008571 PS00070 Aldehyde dehydrogenases cysteine active site. 218491008572 choline dehydrogenase; Validated; Region: PRK02106 218491008573 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 218491008574 HMMPfam hit to PF00732, DE GMC oxidoreductase, score 8.3e-280 218491008575 PS00623 GMC oxidoreductases signature 1. 218491008576 PS00624 GMC oxidoreductases signature 2. 218491008577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 218491008578 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 218491008579 putative metal binding site [ion binding]; other site 218491008580 1 probable transmembrane helix predicted for ECA1747 by TMHMM2.0 at aa 55-77 218491008581 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 218491008582 active site 1 [active] 218491008583 dimer interface [polypeptide binding]; other site 218491008584 active site 2 [active] 218491008585 HMMPfam hit to PF01377, , score 3.2e-74 218491008586 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 218491008587 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218491008588 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 218491008589 outer membrane protein A; Reviewed; Region: PRK10808 218491008590 Signal peptide predicted for ECA1751 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 21 and 22; signal peptide 218491008591 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 218491008592 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218491008593 ligand binding site [chemical binding]; other site 218491008594 HMMPfam hit to PF00691, DE OmpA family, score 3.9e-44 218491008595 PS01068 OmpA-like domain. 218491008596 HMMPfam hit to PF01389, DE OmpA-like transmembrane domain, score 5.9e-95 218491008597 SOS cell division inhibitor; Provisional; Region: PRK10595 218491008598 HMMPfam hit to PF03846, DE Cell division inhibitor SulA, score 5.2e-55 218491008599 TfoX N-terminal domain; Region: TfoX_N; pfam04993 218491008600 TfoX C-terminal domain; Region: TfoX_C; pfam04994 218491008601 TIGR01666 family membrane protein; Region: YCCS 218491008602 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 218491008603 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 218491008604 8 probable transmembrane helices predicted for ECA1754 by TMHMM2.0 at aa 15-37, 68-87, 91-110, 117-139, 143-165, 442-464, 484-503 and 510-532 218491008605 PS00217 Sugar transport proteins signature 2. 218491008606 Predicted membrane protein [Function unknown]; Region: COG3304 218491008607 Domain of unknown function (DUF307); Region: DUF307; pfam03733 218491008608 Domain of unknown function (DUF307); Region: DUF307; pfam03733 218491008609 HMMPfam hit to PF03733, DE Domain of unknown function (DUF307), score 1.7e-30 218491008610 4 probable transmembrane helices predicted for ECA1755 by TMHMM2.0 at aa 2-21, 36-58, 103-125 and 129-151 218491008611 HMMPfam hit to PF03733, DE Domain of unknown function (DUF307), score 2.3e-17 218491008612 DNA helicase IV; Provisional; Region: helD; PRK11054 218491008613 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 218491008614 Part of AAA domain; Region: AAA_19; pfam13245 218491008615 Family description; Region: UvrD_C_2; pfam13538 218491008616 HMMPfam hit to PF00580, DE UvrD/REP helicase, score 6.6e-16 218491008617 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008618 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 218491008619 active site 218491008620 dimer interfaces [polypeptide binding]; other site 218491008621 catalytic residues [active] 218491008622 HMMPfam hit to PF02142, DE MGS-like domain, score 8.5e-29 218491008623 PS01335 Methylglyoxal synthase active site. 218491008624 Signal peptide predicted for ECA1758 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 21 and 22; signal peptide 218491008625 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 218491008626 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 218491008627 HMMPfam hit to PF02629, DE CoA binding domain, score 7.5e-25 218491008628 heat shock protein HspQ; Provisional; Region: PRK14129 218491008629 acylphosphatase; Provisional; Region: PRK14426 218491008630 HMMPfam hit to PF00708, DE Acylphosphatase, score 4.4e-11 218491008631 PS00150 Acylphosphatase signature 1. 218491008632 PS00151 Acylphosphatase signature 2. 218491008633 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218491008634 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 218491008635 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 218491008636 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 218491008637 Signal peptide predicted for ECA1763 by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.724 between residues 41 and 42; signal peptide 218491008638 YccA-like proteins; Region: YccA_like; cd10433 218491008639 HMMPfam hit to PF01027, DE Uncharacterised protein family UPF0005, score 1.5e-55 218491008640 6 probable transmembrane helices predicted for ECA1763 by TMHMM2.0 at aa 44-66, 76-98, 105-127, 133-155, 162-184 and 194-216 218491008641 PS01243 Uncharacterized protein family UPF0005 signature. 218491008642 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 218491008643 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 218491008644 nudix motif; other site 218491008645 HMMPfam hit to PF00293, DE NUDIX domain, score 1.1e-05 218491008646 PS00893 mutT domain signature. 218491008647 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 218491008648 Isochorismatase family; Region: Isochorismatase; pfam00857 218491008649 catalytic triad [active] 218491008650 conserved cis-peptide bond; other site 218491008651 HMMPfam hit to PF00857, DE Isochorismatase family, score 7e-07 218491008652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491008653 Coenzyme A binding pocket [chemical binding]; other site 218491008654 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 7.1e-13 218491008655 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218491008656 Ligand Binding Site [chemical binding]; other site 218491008657 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00582, DE Universal stress protein family, score 8e-07 218491008658 Uncharacterized conserved protein [Function unknown]; Region: COG1683 218491008659 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 218491008660 2 probable transmembrane helices predicted for ECA1771 by TMHMM2.0 at aa 5-27 and 34-56 218491008661 Signal peptide predicted for ECA1772 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25; signal peptide 218491008662 Signal peptide predicted for ECA1774 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.615 between residues 32 and 33; signal peptide 218491008663 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491008664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491008665 dimerization interface [polypeptide binding]; other site 218491008666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491008667 dimer interface [polypeptide binding]; other site 218491008668 putative CheW interface [polypeptide binding]; other site 218491008669 HMMPfam hit to PF03915, DE Actin interacting protein 3, score 19 218491008670 2 probable transmembrane helices predicted for ECA1774 by TMHMM2.0 at aa 10-32 and 188-210 218491008671 HMMPfam hit to PF00672, DE HAMP domain, score 8.2e-12 218491008672 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 7.5e-95 218491008673 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 218491008674 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 218491008675 5 probable transmembrane helices predicted for ECA1775 by TMHMM2.0 at aa 46-68, 188-207, 239-261, 413-435 and 467-489 218491008676 HMMPfam hit to PF03929, DE Uncharacterized iron-regulated membrane protein (DUF337), score 6.2e-23 218491008677 Signal peptide predicted for ECA1776 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.949 between residues 30 and 31; signal peptide 218491008678 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 218491008679 Signal peptide predicted for ECA1777 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.763 between residues 33 and 34; signal peptide 218491008680 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 218491008681 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 218491008682 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 218491008683 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 218491008684 Ligand binding site; other site 218491008685 DXD motif; other site 218491008686 6 probable transmembrane helices predicted for ECA1778 by TMHMM2.0 at aa 154-171, 209-231, 527-549, 583-605, 618-640 and 695-717 218491008687 HMMPfam hit to PF00535, DE Glycosyl transferase, score 9.8e-10 218491008688 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 218491008689 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218491008690 putative acyl-acceptor binding pocket; other site 218491008691 HMMPfam hit to PF03279, DE Bacterial lipid A biosynthesis acyltransferase, score 1.2e-127 218491008692 1 probable transmembrane helix predicted for ECA1779 by TMHMM2.0 at aa 16-38 218491008693 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491008694 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 218491008695 active site 218491008696 FMN binding site [chemical binding]; other site 218491008697 substrate binding site [chemical binding]; other site 218491008698 homotetramer interface [polypeptide binding]; other site 218491008699 catalytic residue [active] 218491008700 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 1.9e-74 218491008701 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 218491008702 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 218491008703 active site residue [active] 218491008704 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008705 HMMPfam hit to PF00581, DE Rhodanese-like domain, score 1.1e-21 218491008706 Signal peptide predicted for ECA1782 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 23 and 24; signal peptide 218491008707 hypothetical protein; Provisional; Region: PRK03757 218491008708 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 218491008709 4 probable transmembrane helices predicted for ECA1783 by TMHMM2.0 at aa 13-35, 50-69, 90-112 and 147-169 218491008710 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 218491008711 DNA damage-inducible protein I; Provisional; Region: PRK10597 218491008712 PS00430 TonB-dependent receptor proteins signature 1. 218491008713 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 218491008714 active site 218491008715 substrate binding pocket [chemical binding]; other site 218491008716 dimer interface [polypeptide binding]; other site 218491008717 PS00483 Dihydroorotase signature 2. 218491008718 Uncharacterized conserved protein [Function unknown]; Region: COG1359 218491008719 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02619, , score 1.8e-20 218491008720 ribonuclease E; Reviewed; Region: rne; PRK10811 218491008721 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 218491008722 homodimer interface [polypeptide binding]; other site 218491008723 oligonucleotide binding site [chemical binding]; other site 218491008724 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 218491008725 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 2.7e-18 218491008726 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 218491008727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491008728 RNA binding surface [nucleotide binding]; other site 218491008729 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218491008730 active site 218491008731 HMMPfam hit to PF01479, DE S4 domain, score 2.4e-09 218491008732 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 1.2e-53 218491008733 PS01129 Rlu family of pseudouridine synthase signature. 218491008734 Maf-like protein; Region: Maf; pfam02545 218491008735 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 218491008736 active site 218491008737 dimer interface [polypeptide binding]; other site 218491008738 HMMPfam hit to PF02545, DE Maf-like protein, score 2.2e-63 218491008739 hypothetical protein; Provisional; Region: PRK11193 218491008740 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 218491008741 HMMPfam hit to PF01783, DE Ribosomal L32p protein family, score 0.0064 218491008742 putative phosphate acyltransferase; Provisional; Region: PRK05331 218491008743 HMMPfam hit to PF02504, DE Fatty acid synthesis protein, score 3.5e-156 218491008744 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 218491008745 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 218491008746 dimer interface [polypeptide binding]; other site 218491008747 active site 218491008748 CoA binding pocket [chemical binding]; other site 218491008749 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 218491008750 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 218491008751 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00698, DE Acyl transferase domain, score 1.2e-107 218491008752 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 218491008753 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 218491008754 NAD(P) binding site [chemical binding]; other site 218491008755 homotetramer interface [polypeptide binding]; other site 218491008756 homodimer interface [polypeptide binding]; other site 218491008757 active site 218491008758 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.9e-94 218491008759 PS00061 Short-chain dehydrogenases/reductases family signature. 218491008760 acyl carrier protein; Provisional; Region: acpP; PRK00982 218491008761 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 8.6e-21 218491008762 PS00012 Phosphopantetheine attachment site. 218491008763 Signal peptide predicted for ECA1799 by SignalP 2.0 HMM (Signal peptide probabilty 0.927) with cleavage site probability 0.695 between residues 20 and 21; signal peptide 218491008764 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 218491008765 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218491008766 dimer interface [polypeptide binding]; other site 218491008767 active site 218491008768 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 8e-81 218491008769 PS00606 Beta-ketoacyl synthases active site. 218491008770 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 3e-75 218491008771 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 218491008772 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 218491008773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491008774 catalytic residue [active] 218491008775 HMMPfam hit to PF01063, DE Aminotransferase class IV, score 1.6e-27 218491008776 PS00770 Aminotransferases class-IV signature. 218491008777 Signal peptide predicted for ECA1801 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.595 between residues 23 and 24; signal peptide 218491008778 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 218491008779 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 218491008780 dimerization interface [polypeptide binding]; other site 218491008781 HMMPfam hit to PF02618, DE Aminodeoxychorismate lyase, score 1.8e-133 218491008782 1 probable transmembrane helix predicted for ECA1801 by TMHMM2.0 at aa 5-22 218491008783 thymidylate kinase; Validated; Region: tmk; PRK00698 218491008784 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 218491008785 TMP-binding site; other site 218491008786 ATP-binding site [chemical binding]; other site 218491008787 HMMPfam hit to PF02223, DE Thymidylate kinase, score 1.5e-78 218491008788 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008789 PS01331 Thymidylate kinase signature. 218491008790 DNA polymerase III subunit delta'; Validated; Region: PRK07993 218491008791 DNA polymerase III subunit delta'; Validated; Region: PRK08485 218491008792 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 218491008793 PS00190 Cytochrome c family heme-binding site signature. 218491008794 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008795 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218491008796 active site 218491008797 PS01137 Uncharacterized protein family UPF0006 signature 1. 218491008798 HMMPfam hit to PF01026, DE TatD related DNase, score 1.8e-119 218491008799 PS01090 Uncharacterized protein family UPF0006 signature 2. 218491008800 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 218491008801 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491008802 Signal peptide predicted for ECA1805 by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.534 between residues 51 and 52; signal peptide 218491008803 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491008804 active site turn [active] 218491008805 phosphorylation site [posttranslational modification] 218491008806 8 probable transmembrane helices predicted for ECA1805 by TMHMM2.0 at aa 13-35, 55-72, 79-101, 116-138, 151-173, 280-302, 309-331 and 354-376 218491008807 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 2.8e-131 218491008808 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 2.4e-15 218491008809 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491008810 Pseudogene. This CDS appears to have a frameshift mutation around codon 110. Similar to Streptomyces coelicolor DNA-binding protein sco0110 or scj11.39C SWALL:Q9RI67 (EMBL:AL939104) (279 aa) fasta scores: E(): 4.2e-35, 44.36% id in 266 aa, and to Rhizobium loti hypothetical protein Mll1636 mll1636 SWALL:Q98K51 (EMBL:AP002997) (290 aa) fasta scores: E(): 4.5e-36, 40.92% id in 259 aa; DNA-binding protein (pseudogene) 218491008811 Predicted helix-turn-helix motif with score 1004.000, SD 2.61 at aa 40-61, sequence LRREEVAALAGVGLTWYTWLEQ 218491008812 Signal peptide predicted for ECA1808 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.731 between residues 19 and 20; signal peptide 218491008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491008814 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 218491008815 putative substrate translocation pore; other site 218491008816 14 probable transmembrane helices predicted for ECA1808 by TMHMM2.0 at aa 29-51, 61-83, 96-118, 123-142, 154-176, 186-208, 220-239, 244-263, 291-313, 323-342, 354-376, 386-408, 429-447 and 462-484 218491008817 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0064 218491008818 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 218491008819 nucleotide binding site/active site [active] 218491008820 HIT family signature motif; other site 218491008821 catalytic residue [active] 218491008822 HMMPfam hit to PF01230, DE HIT family, score 2.6e-58 218491008823 PS00892 HIT family signature. 218491008824 Signal peptide predicted for ECA1810 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.450 between residues 27 and 28; signal peptide 218491008825 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 218491008826 putative dimer interface [polypeptide binding]; other site 218491008827 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008828 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491008829 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 218491008830 Signal peptide predicted for ECA1811 by SignalP 2.0 HMM (Signal peptide probabilty 0.664) with cleavage site probability 0.343 between residues 16 and 17; signal peptide 218491008831 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008832 thiamine kinase; Region: ycfN_thiK; TIGR02721 218491008833 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 218491008834 active site 218491008835 substrate binding site [chemical binding]; other site 218491008836 ATP binding site [chemical binding]; other site 218491008837 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 218491008838 beta-hexosaminidase; Provisional; Region: PRK05337 218491008839 HMMPfam hit to PF00933, DE Glycosyl hydrolase family 3 N terminal domain, score 4.2e-72 218491008840 PS00775 Glycosyl hydrolases family 3 active site. 218491008841 hypothetical protein; Provisional; Region: PRK04940 218491008842 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 218491008843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491008844 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 8.5e-48 218491008845 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491008846 Signal peptide predicted for ECA1816 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.350 between residues 33 and 34; signal peptide 218491008847 hypothetical protein; Provisional; Region: PRK11280 218491008848 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491008849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491008850 putative substrate translocation pore; other site 218491008851 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.012 218491008852 12 probable transmembrane helices predicted for ECA1817 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 113-135, 142-164, 174-196, 216-234, 249-271, 278-300, 304-326, 339-358 and 368-390 218491008853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491008854 putative substrate translocation pore; other site 218491008855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491008856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491008857 putative substrate translocation pore; other site 218491008858 11 probable transmembrane helices predicted for ECA1818 by TMHMM2.0 at aa 15-37, 42-64, 79-98, 105-124, 166-188, 216-238, 248-270, 277-299, 304-326, 339-361 and 366-388 218491008859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491008860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491008861 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 6e-18 218491008862 PS01081 Bacterial regulatory proteins, tetR family signature. 218491008863 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 32-53, sequence TSMDDLTAQASLTRGALYHHFG 218491008864 putative chaperone; Provisional; Region: PRK11678 218491008865 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 218491008866 nucleotide binding site [chemical binding]; other site 218491008867 putative NEF/HSP70 interaction site [polypeptide binding]; other site 218491008868 SBD interface [polypeptide binding]; other site 218491008869 PS00329 Heat shock hsp70 proteins family signature 2. 218491008870 transcription-repair coupling factor; Provisional; Region: PRK10689 218491008871 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 218491008872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491008873 ATP binding site [chemical binding]; other site 218491008874 putative Mg++ binding site [ion binding]; other site 218491008875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491008876 nucleotide binding region [chemical binding]; other site 218491008877 ATP-binding site [chemical binding]; other site 218491008878 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 218491008879 HMMPfam hit to PF03461, DE TRCF domain, score 6.8e-51 218491008880 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 1.3e-19 218491008881 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 8.4e-41 218491008882 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008883 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 218491008884 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218491008885 FtsX-like permease family; Region: FtsX; pfam02687 218491008886 4 probable transmembrane helices predicted for ECA1823 by TMHMM2.0 at aa 25-47, 270-292, 313-335 and 364-386 218491008887 HMMPfam hit to PF02687, DE Predicted permease, score 1.2e-35 218491008888 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 218491008889 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218491008890 Walker A/P-loop; other site 218491008891 ATP binding site [chemical binding]; other site 218491008892 Q-loop/lid; other site 218491008893 ABC transporter signature motif; other site 218491008894 Walker B; other site 218491008895 D-loop; other site 218491008896 H-loop/switch region; other site 218491008897 HMMPfam hit to PF00005, DE ABC transporter, score 1.4e-56 218491008898 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008899 PS00211 ABC transporters family signature. 218491008900 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 218491008901 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218491008902 FtsX-like permease family; Region: FtsX; pfam02687 218491008903 4 probable transmembrane helices predicted for ECA1825 by TMHMM2.0 at aa 21-43, 271-293, 319-341 and 378-400 218491008904 HMMPfam hit to PF02687, DE Predicted permease, score 6e-47 218491008905 PS00027 'Homeobox' domain signature. 218491008906 fructokinase; Reviewed; Region: PRK09557 218491008907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218491008908 nucleotide binding site [chemical binding]; other site 218491008909 HMMPfam hit to PF00480, DE ROK family, score 3.8e-56 218491008910 PS01125 ROK family signature. 218491008911 NAD-dependent deacetylase; Provisional; Region: PRK00481 218491008912 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 218491008913 NAD+ binding site [chemical binding]; other site 218491008914 substrate binding site [chemical binding]; other site 218491008915 Zn binding site [ion binding]; other site 218491008916 HMMPfam hit to PF02146, DE Sir2 family, score 7.8e-80 218491008917 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008918 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 218491008919 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218491008920 ligand binding site [chemical binding]; other site 218491008921 flexible hinge region; other site 218491008922 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 218491008923 Predicted helix-turn-helix motif with score 1192.000, SD 3.25 at aa 183-204, sequence VSRGQLATSLGMRGETLSRLMS 218491008924 HMMPfam hit to PF00027, DE Cyclic nucleotide-binding domain, score 1.1e-16 218491008925 Cupin domain; Region: Cupin_2; cl17218 218491008926 Methyltransferase domain; Region: Methyltransf_31; pfam13847 218491008927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491008928 S-adenosylmethionine binding site [chemical binding]; other site 218491008929 HMMPfam hit to PF01209, DE ubiE/COQ5 methyltransferase family, score 0.00026 218491008930 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491008931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491008932 ABC-ATPase subunit interface; other site 218491008933 dimer interface [polypeptide binding]; other site 218491008934 putative PBP binding regions; other site 218491008935 7 probable transmembrane helices predicted for ECA1832 by TMHMM2.0 at aa 36-58, 78-100, 107-126, 130-152, 165-187, 207-224 and 253-275 218491008936 HMMPfam hit to PF01032, DE FecCD transport family, score 6.6e-95 218491008937 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 218491008938 catalytic residues [active] 218491008939 dimer interface [polypeptide binding]; other site 218491008940 HMMPfam hit to PF00255, DE Glutathione peroxidase, score 1.9e-52 218491008941 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 218491008942 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491008943 Walker A/P-loop; other site 218491008944 ATP binding site [chemical binding]; other site 218491008945 Q-loop/lid; other site 218491008946 ABC transporter signature motif; other site 218491008947 Walker B; other site 218491008948 D-loop; other site 218491008949 H-loop/switch region; other site 218491008950 HMMPfam hit to PF00005, DE ABC transporter, score 2.1e-35 218491008951 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008952 PS00211 ABC transporters family signature. 218491008953 Signal peptide predicted for ECA1835 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.988 between residues 23 and 24; signal peptide 218491008954 NlpC/P60 family; Region: NLPC_P60; pfam00877 218491008955 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008956 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00877, DE NLP/P60 family, score 3e-47 218491008957 phosphogluconate dehydratase; Validated; Region: PRK09054 218491008958 6-phosphogluconate dehydratase; Region: edd; TIGR01196 218491008959 HMMPfam hit to PF00920, DE Dehydratase family, score 6.4e-269 218491008960 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 218491008961 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 218491008962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491008963 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 218491008964 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491008965 DNA binding site [nucleotide binding] 218491008966 domain linker motif; other site 218491008967 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 218491008968 putative ligand binding site [chemical binding]; other site 218491008969 putative dimerization interface [polypeptide binding]; other site 218491008970 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 3.5e-05 218491008971 Predicted helix-turn-helix motif with score 1949.000, SD 5.83 at aa 6-27, sequence PGLQDVANCVGVTKMTISRYLR 218491008972 PS00356 Bacterial regulatory proteins, lacI family signature. 218491008973 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 9.6e-28 218491008974 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 218491008975 ATP-binding site [chemical binding]; other site 218491008976 Gluconate-6-phosphate binding site [chemical binding]; other site 218491008977 Shikimate kinase; Region: SKI; pfam01202 218491008978 PS00017 ATP/GTP-binding site motif A (P-loop). 218491008979 Signal peptide predicted for ECA1840 by SignalP 2.0 HMM (Signal peptide probabilty 0.924) with cleavage site probability 0.465 between residues 34 and 35; signal peptide 218491008980 high-affinity gluconate transporter; Provisional; Region: PRK14984 218491008981 gluconate transporter; Region: gntP; TIGR00791 218491008982 HMMPfam hit to PF02447, DE GntP family permease, score 3.6e-255 218491008983 13 probable transmembrane helices predicted for ECA1840 by TMHMM2.0 at aa 4-18, 25-47, 60-82, 103-120, 125-147, 181-203, 225-247, 259-281, 301-323, 330-351, 355-377, 384-406 and 421-443 218491008984 EAL domain; Region: EAL; pfam00563 218491008985 HMMPfam hit to PF00563, DE EAL domain, score 0.023 218491008986 hypothetical protein; Validated; Region: PRK00029 218491008987 Uncharacterized conserved protein [Function unknown]; Region: COG0397 218491008988 HMMPfam hit to PF02696, DE Uncharacterized ACR, YdiU/UPF0061 family, score 6.8e-192 218491008989 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 218491008990 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491008991 Walker A/P-loop; other site 218491008992 ATP binding site [chemical binding]; other site 218491008993 Q-loop/lid; other site 218491008994 ABC transporter signature motif; other site 218491008995 Walker B; other site 218491008996 D-loop; other site 218491008997 H-loop/switch region; other site 218491008998 HMMPfam hit to PF00005, DE ABC transporter, score 1.1e-43 218491008999 PS00211 ABC transporters family signature. 218491009000 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009001 Signal peptide predicted for ECA1844 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.489 between residues 28 and 29; signal peptide 218491009002 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491009003 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491009004 ABC-ATPase subunit interface; other site 218491009005 dimer interface [polypeptide binding]; other site 218491009006 putative PBP binding regions; other site 218491009007 HMMPfam hit to PF01032, DE FecCD transport family, score 1.8e-126 218491009008 9 probable transmembrane helices predicted for ECA1844 by TMHMM2.0 at aa 9-31, 59-81, 88-110, 114-136, 148-170, 190-212, 241-263, 278-297 and 309-326 218491009009 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009010 Signal peptide predicted for ECA1845 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.976 between residues 18 and 19; signal peptide 218491009011 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 218491009012 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 218491009013 putative hemin binding site; other site 218491009014 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 6.3e-48 218491009015 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 218491009016 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 218491009017 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 218491009018 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 218491009019 Signal peptide predicted for ECA1847 by SignalP 2.0 HMM (Signal peptide probabilty 0.710) with cleavage site probability 0.600 between residues 22 and 23; signal peptide 218491009020 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 218491009021 NAD binding site [chemical binding]; other site 218491009022 sugar binding site [chemical binding]; other site 218491009023 divalent metal binding site [ion binding]; other site 218491009024 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 218491009025 dimer interface [polypeptide binding]; other site 218491009026 HMMPfam hit to PF02056, DE Family 4 glycosyl hydrolase, score 6.9e-205 218491009027 PS01324 Glycosyl hydrolases family 4 signature. 218491009028 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491009029 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 218491009030 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491009031 active site turn [active] 218491009032 phosphorylation site [posttranslational modification] 218491009033 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 2e-13 218491009034 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491009035 12 probable transmembrane helices predicted for ECA1848 by TMHMM2.0 at aa 16-38, 58-80, 87-106, 126-148, 161-183, 198-220, 233-255, 270-292, 304-323, 328-345, 352-374 and 384-406 218491009036 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 5.6e-103 218491009037 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218491009038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491009039 DNA-binding site [nucleotide binding]; DNA binding site 218491009040 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 218491009041 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 4.6e-27 218491009042 PS00043 Bacterial regulatory proteins, gntR family signature. 218491009043 Predicted helix-turn-helix motif with score 1185.000, SD 3.22 at aa 37-58, sequence PAEKHLAKEFSVSRMTVRKALE 218491009044 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 218491009045 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 218491009046 Ca binding site [ion binding]; other site 218491009047 active site 218491009048 catalytic site [active] 218491009049 HMMPfam hit to PF00128, DE Alpha amylase, catalytic domain, score 2.1e-124 218491009050 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 218491009051 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218491009052 HMMPfam hit to PF00793, DE DAHP synthetase I family, score 3.1e-158 218491009053 PEP synthetase regulatory protein; Provisional; Region: PRK05339 218491009054 HMMPfam hit to PF03618, DE Domain of unknown function (DUF299), score 1.5e-144 218491009055 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009056 phosphoenolpyruvate synthase; Validated; Region: PRK06464 218491009057 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 218491009058 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218491009059 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218491009060 HMMPfam hit to PF01326, DE Pyruvate phosphate dikinase, PEP/pyruvate binding domain, score 1.4e-161 218491009061 HMMPfam hit to PF00391, DE PEP-utilising enzyme, mobile domain, score 2.4e-42 218491009062 PS00370 PEP-utilizing enzymes phosphorylation site signature. 218491009063 HMMPfam hit to PF02896, DE PEP-utilising enzyme, TIM barrel domain, score 8.7e-128 218491009064 PS00742 PEP-utilizing enzymes signature 2. 218491009065 Signal peptide predicted for ECA1854 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.565 between residues 20 and 21; signal peptide 218491009066 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 218491009067 ApbE family; Region: ApbE; pfam02424 218491009068 HMMPfam hit to PF02424, DE ApbE family, score 3.9e-121 218491009069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009070 putative inner membrane protein; Provisional; Region: PRK10983 218491009071 Domain of unknown function DUF20; Region: UPF0118; pfam01594 218491009072 HMMPfam hit to PF01594, DE Domain of unknown function DUF20, score 2.6e-48 218491009073 8 probable transmembrane helices predicted for ECA1855 by TMHMM2.0 at aa 94-116, 120-142, 149-171, 242-264, 299-321, 331-353, 366-385 and 400-422 218491009074 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009075 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 218491009076 FAD binding domain; Region: FAD_binding_4; pfam01565 218491009077 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 218491009078 HMMPfam hit to PF01565, DE FAD binding domain, score 2.6e-56 218491009079 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009080 HMMPfam hit to PF02913, DE FAD linked oxidases, C-terminal domain, score 3.1e-65 218491009081 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491009082 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009083 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218491009084 CoenzymeA binding site [chemical binding]; other site 218491009085 subunit interaction site [polypeptide binding]; other site 218491009086 PHB binding site; other site 218491009087 HMMPfam hit to PF02584, , score 3.1e-54 218491009088 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 218491009089 HMMPfam hit to PF01521, DE HesB-like domain, score 3.6e-47 218491009090 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 218491009091 putative ABC transporter; Region: ycf24; CHL00085 218491009092 HMMPfam hit to PF01458, DE Uncharacterized protein family (UPF0051), score 2e-146 218491009093 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 218491009094 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 218491009095 Walker A/P-loop; other site 218491009096 ATP binding site [chemical binding]; other site 218491009097 Q-loop/lid; other site 218491009098 ABC transporter signature motif; other site 218491009099 Walker B; other site 218491009100 D-loop; other site 218491009101 H-loop/switch region; other site 218491009102 HMMPfam hit to PF00005, DE ABC transporter, score 1.7e-33 218491009103 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009104 PS00211 ABC transporters family signature. 218491009105 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 218491009106 FeS assembly protein SufD; Region: sufD; TIGR01981 218491009107 HMMPfam hit to PF01458, DE Uncharacterized protein family (UPF0051), score 1.5e-82 218491009108 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 218491009109 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 218491009110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491009111 catalytic residue [active] 218491009112 HMMPfam hit to PF00266, DE Aminotransferase class-V, score 2.8e-12 218491009113 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218491009114 cysteine desufuration protein SufE; Provisional; Region: PRK09296 218491009115 HMMPfam hit to PF02657, DE Fe-S metabolism associated domain, score 5e-60 218491009116 Signal peptide predicted for ECA1865 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.881 between residues 23 and 24; signal peptide 218491009117 L,D-transpeptidase; Provisional; Region: PRK10190 218491009118 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218491009119 HMMPfam hit to PF03734, DE ErfK/YbiS/YcfS/YnhG, score 1e-68 218491009120 murein lipoprotein; Provisional; Region: PRK15396 218491009121 Signal peptide predicted for ECA1866 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.923 between residues 25 and 26; signal peptide 218491009122 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009123 pyruvate kinase; Provisional; Region: PRK09206 218491009124 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 218491009125 domain interfaces; other site 218491009126 active site 218491009127 HMMPfam hit to PF02887, DE Pyruvate kinase, alpha/beta domain, score 2.2e-25 218491009128 HMMPfam hit to PF00224, DE Pyruvate kinase, barrel domain, score 6.3e-190 218491009129 PS00110 Pyruvate kinase active site signature. 218491009130 transcriptional antiterminator BglG; Provisional; Region: PRK09772 218491009131 CAT RNA binding domain; Region: CAT_RBD; smart01061 218491009132 PRD domain; Region: PRD; pfam00874 218491009133 PRD domain; Region: PRD; pfam00874 218491009134 HMMPfam hit to PF03123, DE CAT RNA binding domain, score 0.0014 218491009135 HMMPfam hit to PF00874, DE PRD domain, score 1.7e-49 218491009136 PS00654 Transcriptional antiterminators bglG family signature. 218491009137 HMMPfam hit to PF00874, DE PRD domain, score 4.9e-19 218491009138 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009139 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 218491009140 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491009141 active site turn [active] 218491009142 phosphorylation site [posttranslational modification] 218491009143 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491009144 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218491009145 HPr interaction site; other site 218491009146 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218491009147 active site 218491009148 phosphorylation site [posttranslational modification] 218491009149 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 1.4e-18 218491009150 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491009151 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 1.4e-14 218491009152 9 probable transmembrane helices predicted for ECA1870 by TMHMM2.0 at aa 113-135, 148-167, 177-196, 208-230, 250-272, 293-315, 330-350, 388-410 and 434-456 218491009153 HMMPfam hit to PF00358, DE phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 8.7e-68 218491009154 PS00371 PTS EIIA domains phosphorylation site signature 1. 218491009155 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218491009156 beta-galactosidase; Region: BGL; TIGR03356 218491009157 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 2.2e-212 218491009158 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491009159 PS00572 Glycosyl hydrolases family 1 active site. 218491009160 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 218491009161 Signal peptide predicted for ECA1872 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 25 and 26; signal peptide 218491009162 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 218491009163 trimer interface; other site 218491009164 sugar binding site [chemical binding]; other site 218491009165 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02264, DE LamB porin, score 9.4e-138 218491009166 Signal peptide predicted for ECA1873 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.820 between residues 27 and 28; signal peptide 218491009167 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 218491009168 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 218491009169 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 218491009170 HMMPfam hit to PF02922, DE Isoamylase N-terminal domain, score 0.00042 218491009171 Signal peptide predicted for ECA1874 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 27 and 28; signal peptide 218491009172 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 218491009173 active site 218491009174 HMMPfam hit to PF01156, DE Inosine-uridine preferring nucleoside hydrolase, score 4.6e-05 218491009175 Signal peptide predicted for ECA1875 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.937 between residues 26 and 27; signal peptide 218491009176 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 218491009177 HMMPfam hit to PF02335, DE Cytochrome c552, score 0 218491009178 PS00190 Cytochrome c family heme-binding site signature. 218491009179 PS00190 Cytochrome c family heme-binding site signature. 218491009180 PS00190 Cytochrome c family heme-binding site signature. 218491009181 PS00190 Cytochrome c family heme-binding site signature. 218491009182 Signal peptide predicted for ECA1876 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.671 between residues 20 and 21; signal peptide 218491009183 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 218491009184 PS00190 Cytochrome c family heme-binding site signature. 218491009185 PS00190 Cytochrome c family heme-binding site signature. 218491009186 PS00190 Cytochrome c family heme-binding site signature. 218491009187 PS00190 Cytochrome c family heme-binding site signature. 218491009188 PS00190 Cytochrome c family heme-binding site signature. 218491009189 Signal peptide predicted for ECA1877 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.995 between residues 27 and 28; signal peptide 218491009190 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 218491009191 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.004 218491009192 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 7.1e-05 218491009193 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009194 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 218491009195 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 218491009196 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03916, DE Polysulphide reductase, NrfD, score 8.1e-124 218491009197 8 probable transmembrane helices predicted for ECA1878 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 152-171, 181-203, 224-243, 258-280 and 292-314 218491009198 Signal peptide predicted for ECA1879 by SignalP 2.0 HMM (Signal peptide probabilty 0.643) with cleavage site probability 0.302 between residues 34 and 35; signal peptide 218491009199 heme lyase subunit NrfE; Provisional; Region: PRK10369 218491009200 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 218491009201 14 probable transmembrane helices predicted for ECA1879 by TMHMM2.0 at aa 10-32, 44-66, 89-111, 124-146, 176-198, 211-233, 243-265, 278-300, 315-334, 355-377, 397-416, 423-445, 474-496 and 598-620 218491009202 HMMPfam hit to PF01578, DE Cytochrome C assembly protein, score 5.2e-33 218491009203 Signal peptide predicted for ECA1880 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.550 between residues 20 and 21; signal peptide 218491009204 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 218491009205 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03918, DE Cytochrome C biogenesis protein, score 2.1e-36 218491009206 2 probable transmembrane helices predicted for ECA1880 by TMHMM2.0 at aa 5-27 and 102-124 218491009207 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 218491009208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491009209 binding surface 218491009210 TPR motif; other site 218491009211 2 probable transmembrane helices predicted for ECA1881 by TMHMM2.0 at aa 7-25 and 85-107 218491009212 HMMPfam hit to PF00515, DE TPR Domain, score 0.0041 218491009213 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 218491009214 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 218491009215 Walker A/P-loop; other site 218491009216 ATP binding site [chemical binding]; other site 218491009217 Q-loop/lid; other site 218491009218 ABC transporter signature motif; other site 218491009219 Walker B; other site 218491009220 D-loop; other site 218491009221 H-loop/switch region; other site 218491009222 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-36 218491009223 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009224 PS00211 ABC transporters family signature. 218491009225 heme exporter protein CcmB; Region: ccmB; TIGR01190 218491009226 HMMPfam hit to PF03379, DE CcmB protein, score 4.5e-116 218491009227 6 probable transmembrane helices predicted for ECA1883 by TMHMM2.0 at aa 20-37, 42-64, 95-117, 127-149, 156-178 and 193-215 218491009228 heme exporter protein CcmC; Region: ccmC; TIGR01191 218491009229 6 probable transmembrane helices predicted for ECA1884 by TMHMM2.0 at aa 21-43, 58-80, 93-115, 130-149, 158-180 and 200-222 218491009230 HMMPfam hit to PF01578, DE Cytochrome C assembly protein, score 8.4e-53 218491009231 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009232 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 218491009233 1 probable transmembrane helix predicted for ECA1885 by TMHMM2.0 at aa 20-42 218491009234 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 218491009235 Signal peptide predicted for ECA1886 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.572 between residues 31 and 32; signal peptide 218491009236 HMMPfam hit to PF03100, DE CcmE, score 5.9e-73 218491009237 1 probable transmembrane helix predicted for ECA1886 by TMHMM2.0 at aa 9-31 218491009238 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 218491009239 15 probable transmembrane helices predicted for ECA1887 by TMHMM2.0 at aa 6-28, 41-63, 95-114, 121-143, 171-193, 214-233, 248-265, 277-299, 314-332, 353-375, 390-412, 425-444, 448-467, 488-510 and 617-636 218491009240 HMMPfam hit to PF01578, DE Cytochrome C assembly protein, score 7e-57 218491009241 Signal peptide predicted for ECA1888 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.517 between residues 19 and 20; signal peptide 218491009242 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 218491009243 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218491009244 catalytic residues [active] 218491009245 central insert; other site 218491009246 1 probable transmembrane helix predicted for ECA1888 by TMHMM2.0 at aa 5-25 218491009247 PS00194 Thioredoxin family active site. 218491009248 Signal peptide predicted for ECA1889 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.942 between residues 18 and 19; signal peptide 218491009249 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 218491009250 HMMPfam hit to PF03918, DE Cytochrome C biogenesis protein, score 5.7e-62 218491009251 1 probable transmembrane helix predicted for ECA1889 by TMHMM2.0 at aa 98-120 218491009252 Signal peptide predicted for ECA1890 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.409 between residues 21 and 22; signal peptide 218491009253 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 218491009254 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 218491009255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491009256 binding surface 218491009257 TPR motif; other site 218491009258 2 probable transmembrane helices predicted for ECA1890 by TMHMM2.0 at aa 4-23 and 85-107 218491009259 HMMPfam hit to PF00515, DE TPR Domain, score 0.5 218491009260 HMMPfam hit to PF00515, DE TPR Domain, score 0.82 218491009261 cytochrome c-type protein NapC; Provisional; Region: PRK10617 218491009262 Signal peptide predicted for ECA1892 by SignalP 2.0 HMM (Signal peptide probabilty 0.906) with cleavage site probability 0.244 between residues 45 and 46; signal peptide 218491009263 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 218491009264 HMMPfam hit to PF03264, DE NapC/NirT cytochrome c family, N-terminal region, score 3.4e-108 218491009265 PS00190 Cytochrome c family heme-binding site signature. 218491009266 PS00190 Cytochrome c family heme-binding site signature. 218491009267 PS00190 Cytochrome c family heme-binding site signature. 218491009268 1 probable transmembrane helix predicted for ECA1892 by TMHMM2.0 at aa 28-47 218491009269 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 218491009270 Signal peptide predicted for ECA1893 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.775 between residues 25 and 26; signal peptide 218491009271 HMMPfam hit to PF03892, DE Nitrate reductase cytochrome c-type subunit (NapB), score 7.9e-44 218491009272 PS00190 Cytochrome c family heme-binding site signature. 218491009273 PS00190 Cytochrome c family heme-binding site signature. 218491009274 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 218491009275 4Fe-4S binding domain; Region: Fer4_5; pfam12801 218491009276 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491009277 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.011 218491009278 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009279 4 probable transmembrane helices predicted for ECA1894 by TMHMM2.0 at aa 33-55, 75-97, 138-160 and 170-192 218491009280 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 218491009281 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.024 218491009282 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00025 218491009283 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009284 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 218491009285 Signal peptide predicted for ECA1896 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.871 between residues 31 and 32; signal peptide 218491009286 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 218491009287 [4Fe-4S] binding site [ion binding]; other site 218491009288 molybdopterin cofactor binding site; other site 218491009289 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 218491009290 molybdopterin cofactor binding site; other site 218491009291 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 2.2e-40 218491009292 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 4.8e-179 218491009293 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 218491009294 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 218491009295 HMMPfam hit to PF03927, DE NapD protein, score 2.7e-23 218491009296 ferredoxin-type protein; Provisional; Region: PRK10194 218491009297 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 218491009298 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 4.9e-05 218491009299 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009300 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.026 218491009301 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009302 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.0039 218491009303 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009304 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 218491009305 Signal peptide predicted for ECA1900 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.684 between residues 34 and 35; signal peptide 218491009306 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 218491009307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491009308 dimerization interface [polypeptide binding]; other site 218491009309 Histidine kinase; Region: HisKA_3; pfam07730 218491009310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491009311 ATP binding site [chemical binding]; other site 218491009312 Mg2+ binding site [ion binding]; other site 218491009313 G-X-G motif; other site 218491009314 2 probable transmembrane helices predicted for ECA1900 by TMHMM2.0 at aa 15-37 and 147-169 218491009315 HMMPfam hit to PF00672, DE HAMP domain, score 9.1e-08 218491009316 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 4.7e-18 218491009317 transcriptional regulator NarP; Provisional; Region: PRK10403 218491009318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491009319 active site 218491009320 phosphorylation site [posttranslational modification] 218491009321 intermolecular recognition site; other site 218491009322 dimerization interface [polypeptide binding]; other site 218491009323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491009324 DNA binding residues [nucleotide binding] 218491009325 dimerization interface [polypeptide binding]; other site 218491009326 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.7e-37 218491009327 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 1.5e-22 218491009328 PS00622 Bacterial regulatory proteins, luxR family signature. 218491009329 Predicted helix-turn-helix motif with score 1579.000, SD 4.56 at aa 169-190, sequence LSNKQIAAVLYISEETVKVHIR 218491009330 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491009331 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218491009332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491009333 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.82 218491009334 Predicted helix-turn-helix motif with score 1168.000, SD 3.17 at aa 199-220, sequence LTTSVLAEAAALSRVRLNQLFS 218491009335 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.004 218491009336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491009337 14 probable transmembrane helices predicted for ECA1903 by TMHMM2.0 at aa 20-42, 57-76, 88-110, 120-139, 146-168, 173-195, 208-230, 235-257, 270-292, 307-329, 336-355, 370-392, 412-429 and 434-453 218491009338 PS00216 Sugar transport proteins signature 1. 218491009339 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 218491009340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 218491009341 putative NAD(P) binding site [chemical binding]; other site 218491009342 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 7.7e-68 218491009343 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 218491009344 Signal peptide predicted for ECA1905 by SignalP 2.0 HMM (Signal peptide probabilty 0.952) with cleavage site probability 0.939 between residues 21 and 22; signal peptide 218491009345 classical (c) SDRs; Region: SDR_c; cd05233 218491009346 NAD(P) binding site [chemical binding]; other site 218491009347 active site 218491009348 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 4.5e-41 218491009349 PS00061 Short-chain dehydrogenases/reductases family signature. 218491009350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491009351 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218491009352 active site 218491009353 motif I; other site 218491009354 motif II; other site 218491009355 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491009356 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 0.0017 218491009357 PS01229 Hypothetical cof family signature 2. 218491009358 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218491009359 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 218491009360 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218491009361 HMMPfam hit to PF00455, DE Bacterial regulatory proteins, deoR family, score 1.4e-43 218491009362 Predicted helix-turn-helix motif with score 1733.000, SD 5.09 at aa 25-46, sequence VVCTQLSRELNVSEHTIRRDLK 218491009363 PS00894 Bacterial regulatory proteins, deoR family signature. 218491009364 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 218491009365 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218491009366 putative active site [active] 218491009367 putative metal binding site [ion binding]; other site 218491009368 4 probable transmembrane helices predicted for ECA1908 by TMHMM2.0 at aa 4-19, 31-50, 60-82 and 103-125 218491009369 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 3.4e-15 218491009370 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 218491009371 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 218491009372 dimer interface [polypeptide binding]; other site 218491009373 active site 218491009374 heme binding site [chemical binding]; other site 218491009375 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 218491009376 HMMPfam hit to PF00141, DE Peroxidase, score 4.1e-87 218491009377 PS00436 Peroxidases active site signature. 218491009378 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009379 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 218491009380 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218491009381 MarR family; Region: MarR_2; cl17246 218491009382 HMMPfam hit to PF01047, DE MarR family, score 3e-24 218491009383 Predicted helix-turn-helix motif with score 1037.000, SD 2.72 at aa 44-65, sequence ITPQSLAKAVGRDKAQITRMVA 218491009384 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 218491009385 Signal peptide predicted for ECA1912 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25; signal peptide 218491009386 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 218491009387 Signal peptide predicted for ECA1913 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.470 between residues 35 and 36; signal peptide 218491009388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218491009389 5 probable transmembrane helices predicted for ECA1913 by TMHMM2.0 at aa 12-34, 84-106, 113-135, 201-223 and 236-258 218491009390 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491009391 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491009392 Walker A/P-loop; other site 218491009393 ATP binding site [chemical binding]; other site 218491009394 Q-loop/lid; other site 218491009395 ABC transporter signature motif; other site 218491009396 Walker B; other site 218491009397 D-loop; other site 218491009398 H-loop/switch region; other site 218491009399 HMMPfam hit to PF00005, DE ABC transporter, score 9.2e-54 218491009400 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009401 PS00211 ABC transporters family signature. 218491009402 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 218491009403 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 218491009404 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 218491009405 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 218491009406 urea carboxylase; Region: urea_carbox; TIGR02712 218491009407 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218491009408 ATP-grasp domain; Region: ATP-grasp_4; cl17255 218491009409 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 218491009410 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 218491009411 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 218491009412 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 218491009413 carboxyltransferase (CT) interaction site; other site 218491009414 biotinylation site [posttranslational modification]; other site 218491009415 HMMPfam hit to PF00289, DE Carbamoyl-phosphate synthase L chain, N-terminal domain, score 2.7e-43 218491009416 HMMPfam hit to PF02786, DE Carbamoyl-phosphate synthase L chain, ATP binding domain, score 2.9e-73 218491009417 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218491009418 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218491009419 HMMPfam hit to PF02785, DE Biotin carboxylase C-terminal domain, score 2.6e-44 218491009420 HMMPfam hit to PF02626, DE Allophanate hydrolase subunit 2, score 6.5e-95 218491009421 HMMPfam hit to PF02682, DE Allophanate hydrolase subunit 1, score 0.00029 218491009422 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 1.1e-16 218491009423 Uncharacterized conserved protein [Function unknown]; Region: COG1556 218491009424 HMMPfam hit to PF02589, DE Uncharacterized ACR, YkgG family COG1556, score 6e-70 218491009425 iron-sulfur cluster-binding protein; Region: TIGR00273 218491009426 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 218491009427 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491009428 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 218491009429 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.15 218491009430 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009431 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491009432 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 218491009433 Cysteine-rich domain; Region: CCG; pfam02754 218491009434 Cysteine-rich domain; Region: CCG; pfam02754 218491009435 HMMPfam hit to PF02754, DE Cysteine-rich domain, score 3.6e-13 218491009436 HMMPfam hit to PF02754, DE Cysteine-rich domain, score 9.7e-12 218491009437 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 218491009438 L-lactate permease; Region: Lactate_perm; cl00701 218491009439 13 probable transmembrane helices predicted for ECA1921 by TMHMM2.0 at aa 5-22, 27-49, 56-78, 118-140, 147-169, 184-206, 213-235, 239-256, 290-309, 334-356, 377-399, 409-428 and 496-515 218491009440 HMMPfam hit to PF02652, DE L-lactate permease, score 1.1e-140 218491009441 multidrug efflux protein; Reviewed; Region: PRK01766 218491009442 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 218491009443 cation binding site [ion binding]; other site 218491009444 12 probable transmembrane helices predicted for ECA1922 by TMHMM2.0 at aa 13-35, 50-72, 91-113, 128-147, 160-179, 189-211, 239-261, 271-293, 314-336, 351-373, 386-408 and 418-440 218491009445 HMMPfam hit to PF01554, DE MatE, score 5.4e-47 218491009446 HMMPfam hit to PF01554, DE MatE, score 2.3e-45 218491009447 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 218491009448 Lumazine binding domain; Region: Lum_binding; pfam00677 218491009449 Lumazine binding domain; Region: Lum_binding; pfam00677 218491009450 HMMPfam hit to PF00677, DE Lumazine binding domain, score 2.1e-34 218491009451 HMMPfam hit to PF00677, DE Lumazine binding domain, score 1.3e-35 218491009452 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 218491009453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491009454 S-adenosylmethionine binding site [chemical binding]; other site 218491009455 HMMPfam hit to PF02353, DE Cyclopropane-fatty-acyl-phospholipid synthase, score 8.4e-68 218491009456 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 218491009457 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491009458 DNA binding site [nucleotide binding] 218491009459 domain linker motif; other site 218491009460 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 218491009461 dimerization interface [polypeptide binding]; other site 218491009462 ligand binding site [chemical binding]; other site 218491009463 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 2.8e-22 218491009464 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 3.4e-11 218491009465 Predicted helix-turn-helix motif with score 2093.000, SD 6.32 at aa 2-23, sequence ATIKDVAKRAGVSTTTVSHVIN 218491009466 PS00356 Bacterial regulatory proteins, lacI family signature. 218491009467 Signal peptide predicted for ECA1926 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.878 between residues 22 and 23; signal peptide 218491009468 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 218491009469 NlpC/P60 family; Region: NLPC_P60; pfam00877 218491009470 HMMPfam hit to PF00877, DE NLP/P60 family, score 3e-54 218491009471 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 218491009472 putative GSH binding site [chemical binding]; other site 218491009473 catalytic residues [active] 218491009474 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 218491009475 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 218491009476 dimer interface [polypeptide binding]; other site 218491009477 catalytic site [active] 218491009478 putative active site [active] 218491009479 putative substrate binding site [chemical binding]; other site 218491009480 HMMPfam hit to PF00929, DE Exonuclease, score 3e-35 218491009481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491009482 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 218491009483 dimer interface [polypeptide binding]; other site 218491009484 active site 218491009485 metal binding site [ion binding]; metal-binding site 218491009486 glutathione binding site [chemical binding]; other site 218491009487 HMMPfam hit to PF00903, DE Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 4.6e-41 218491009488 PS00935 Glyoxalase I signature 2. 218491009489 PS00934 Glyoxalase I signature 1. 218491009490 Predicted Fe-S protein [General function prediction only]; Region: COG3313 218491009491 1 probable transmembrane helix predicted for ECA1930 by TMHMM2.0 at aa 7-26 218491009492 transcriptional regulator SlyA; Provisional; Region: PRK03573 218491009493 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 218491009494 HMMPfam hit to PF01047, DE MarR family, score 1.4e-22 218491009495 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 47-68, sequence QSQIQLAKAIGIEQPSLVRTLD 218491009496 PS01117 Bacterial regulatory proteins, marR family signature. 218491009497 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 218491009498 Signal peptide predicted for ECA1932 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.325 between residues 21 and 22; signal peptide 218491009499 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009500 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 218491009501 HMMPfam hit to PF03702, DE Uncharacterised protein family (UPF0075), score 1.2e-222 218491009502 lysozyme inhibitor; Provisional; Region: PRK11372 218491009503 Signal peptide predicted for ECA1934 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.574 between residues 20 and 21; signal peptide 218491009504 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 218491009505 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009506 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 218491009507 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 218491009508 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 218491009509 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01243, DE Pyridoxamine 5'-phosphate oxidase, score 2.7e-131 218491009510 PS01064 Pyridoxamine 5'-phosphate oxidase signature. 218491009511 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 218491009512 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 218491009513 active site 218491009514 HIGH motif; other site 218491009515 dimer interface [polypeptide binding]; other site 218491009516 KMSKS motif; other site 218491009517 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491009518 RNA binding surface [nucleotide binding]; other site 218491009519 HMMPfam hit to PF00579, DE tRNA synthetases class I (W and Y), score 3.3e-122 218491009520 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491009521 HMMPfam hit to PF01479, DE S4 domain, score 3.9e-06 218491009522 pyridoxamine kinase; Validated; Region: PRK05756 218491009523 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 218491009524 dimer interface [polypeptide binding]; other site 218491009525 pyridoxal binding site [chemical binding]; other site 218491009526 ATP binding site [chemical binding]; other site 218491009527 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 0.47 218491009528 glutathionine S-transferase; Provisional; Region: PRK10542 218491009529 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 218491009530 C-terminal domain interface [polypeptide binding]; other site 218491009531 GSH binding site (G-site) [chemical binding]; other site 218491009532 dimer interface [polypeptide binding]; other site 218491009533 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 218491009534 dimer interface [polypeptide binding]; other site 218491009535 N-terminal domain interface [polypeptide binding]; other site 218491009536 substrate binding pocket (H-site) [chemical binding]; other site 218491009537 HMMPfam hit to PF00043, DE Glutathione S-transferase, C-terminal domain, score 4.6e-13 218491009538 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 7.7e-12 218491009539 Signal peptide predicted for ECA1939 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.403 between residues 30 and 31; signal peptide 218491009540 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 218491009541 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218491009542 HMMPfam hit to PF00375, DE Sodium:dicarboxylate symporter family, score 8.3e-110 218491009543 8 probable transmembrane helices predicted for ECA1939 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 154-171, 198-220, 230-252, 305-327 and 359-381 218491009544 1 probable transmembrane helix predicted for ECA1940 by TMHMM2.0 at aa 4-26 218491009545 aconitate hydratase; Validated; Region: PRK09277 218491009546 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 218491009547 substrate binding site [chemical binding]; other site 218491009548 ligand binding site [chemical binding]; other site 218491009549 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 218491009550 substrate binding site [chemical binding]; other site 218491009551 HMMPfam hit to PF00330, DE Aconitase family (aconitate hydratase), score 1e-269 218491009552 PS00450 Aconitase family signature 1. 218491009553 PS01244 Aconitase family signature 2. 218491009554 HMMPfam hit to PF00694, DE Aconitase C-terminal domain, score 6.6e-83 218491009555 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 218491009556 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218491009557 peptide binding site [polypeptide binding]; other site 218491009558 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 6.4e-150 218491009559 1 probable transmembrane helix predicted for ECA1942 by TMHMM2.0 at aa 68-90 218491009560 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 218491009561 dimerization interface [polypeptide binding]; other site 218491009562 active site 218491009563 HMMPfam hit to PF00925, DE GTP cyclohydrolase II, score 5.1e-109 218491009564 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218491009565 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 218491009566 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218491009567 active site 218491009568 6 probable transmembrane helices predicted for ECA1944 by TMHMM2.0 at aa 7-29, 49-68, 75-92, 157-179, 186-208 and 212-230 218491009569 HMMPfam hit to PF01569, DE PAP2 superfamily, score 9.4e-15 218491009570 Pseudogene. This CDS appears to have a frameshift mutation following codon 33. Similar to Escherichia coli D-ribose-binding periplasmic protein precursor RbsB or RbsP or PrlB or b3751 SWALL:RBSB_ECOLI (SWALL:P02925) (296 aa) fasta scores: E(): 5.2e-21, 31.11% id in 286 aa, and to Yersinia pestis D-ribose binding protein RbsB or ypo3318 SWALL:Q9X6A9 (EMBL:AF135170) (324 aa) fasta scores: E(): 4.4e-92, 84.61% id in 312 aa; sugar-binding periplasmic protein (pseudogene) 218491009571 Signal peptide predicted for ECA1945 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.979 between residues 23 and 24 218491009572 1 probable transmembrane helix predicted for ECA1945 by TMHMM2.0 at aa 34-56 218491009573 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 218491009574 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009575 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 218491009576 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491009577 Walker A/P-loop; other site 218491009578 ATP binding site [chemical binding]; other site 218491009579 Q-loop/lid; other site 218491009580 ABC transporter signature motif; other site 218491009581 Walker B; other site 218491009582 D-loop; other site 218491009583 H-loop/switch region; other site 218491009584 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491009585 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-51 218491009586 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009587 HMMPfam hit to PF00005, DE ABC transporter, score 4.4e-23 218491009588 PS00211 ABC transporters family signature. 218491009589 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491009590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491009591 TM-ABC transporter signature motif; other site 218491009592 10 probable transmembrane helices predicted for ECA1949 by TMHMM2.0 at aa 38-60, 65-87, 94-116, 120-142, 147-169, 194-216, 247-269, 274-296, 301-320 and 325-342 218491009593 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 1.9e-05 218491009594 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218491009595 TPP-binding site [chemical binding]; other site 218491009596 dimer interface [polypeptide binding]; other site 218491009597 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00456, DE Transketolase, thiamine diphosphate binding domain, score 1.9e-16 218491009598 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 218491009599 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218491009600 PYR/PP interface [polypeptide binding]; other site 218491009601 dimer interface [polypeptide binding]; other site 218491009602 TPP binding site [chemical binding]; other site 218491009603 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218491009604 HMMPfam hit to PF02779, DE Transketolase, pyridine binding domain, score 1.5e-11 218491009605 HMMPfam hit to PF02780, DE Transketolase, C-terminal domain, score 1.2e-25 218491009606 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 218491009607 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 218491009608 N- and C-terminal domain interface [polypeptide binding]; other site 218491009609 active site 218491009610 MgATP binding site [chemical binding]; other site 218491009611 catalytic site [active] 218491009612 metal binding site [ion binding]; metal-binding site 218491009613 putative homotetramer interface [polypeptide binding]; other site 218491009614 putative homodimer interface [polypeptide binding]; other site 218491009615 glycerol binding site [chemical binding]; other site 218491009616 HMMPfam hit to PF00370, DE FGGY family of carbohydrate kinases, N-terminal domain, score 1.7e-67 218491009617 HMMPfam hit to PF02782, DE FGGY family of carbohydrate kinases, C-terminal domain, score 8.8e-38 218491009618 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 218491009619 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 218491009620 HMMPfam hit to PF00259, DE Xylose isomerase, score 2.7e-06 218491009621 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 218491009622 MarR family; Region: MarR_2; cl17246 218491009623 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 218491009624 Predicted helix-turn-helix motif with score 1893.000, SD 5.63 at aa 22-43, sequence MKQAEIAASLHLSQSFVSRAIT 218491009625 Predicted membrane protein [Function unknown]; Region: COG3771 218491009626 Signal peptide predicted for ECA1955 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.567 between residues 24 and 25; signal peptide 218491009627 2 probable transmembrane helices predicted for ECA1955 by TMHMM2.0 at aa 5-23 and 43-65 218491009628 tetratricopeptide repeat protein; Provisional; Region: PRK11788 218491009629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491009630 TPR motif; other site 218491009631 binding surface 218491009632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 218491009633 binding surface 218491009634 TPR motif; other site 218491009635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491009636 binding surface 218491009637 TPR motif; other site 218491009638 HMMPfam hit to PF00515, DE TPR Domain, score 8.3 218491009639 HMMPfam hit to PF00515, DE TPR Domain, score 0.0082 218491009640 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 218491009641 active site 218491009642 dimer interface [polypeptide binding]; other site 218491009643 HMMPfam hit to PF00215, DE Orotidine 5'-phosphate decarboxylase / HUMPS family, score 2.4e-83 218491009644 PS00156 Orotidine 5'-phosphate decarboxylase active site. 218491009645 translation initiation factor Sui1; Validated; Region: PRK06824 218491009646 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 218491009647 putative rRNA binding site [nucleotide binding]; other site 218491009648 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01253, DE Translation initiation factor SUI1, score 2.4e-43 218491009649 PS01118 Translation initiation factor SUI1 signature. 218491009650 lipoprotein; Provisional; Region: PRK10540 218491009651 Signal peptide predicted for ECA1959 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.373 between residues 22 and 23; signal peptide 218491009652 2 probable transmembrane helices predicted for ECA1959 by TMHMM2.0 at aa 7-24 and 44-66 218491009653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009654 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 218491009655 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 218491009656 intersubunit interface [polypeptide binding]; other site 218491009657 active site 218491009658 Zn2+ binding site [ion binding]; other site 218491009659 HMMPfam hit to PF00596, DE Class II Aldolase and Adducin N-terminal domain, score 1.8e-97 218491009660 carbon starvation protein A; Provisional; Region: PRK15015 218491009661 Carbon starvation protein CstA; Region: CstA; pfam02554 218491009662 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 218491009663 18 probable transmembrane helices predicted for ECA1961 by TMHMM2.0 at aa 36-58, 63-85, 118-140, 145-167, 188-210, 220-242, 247-269, 284-306, 313-332, 352-374, 387-409, 424-446, 463-482, 492-511, 540-562, 572-594, 601-623 and 669-691 218491009664 HMMPfam hit to PF02554, DE Carbon starvation protein CstA, score 4.8e-250 218491009665 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491009667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491009668 active site 218491009669 catalytic tetrad [active] 218491009670 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 9.6e-27 218491009671 PS00136 Serine proteases, subtilase family, aspartic acid active site. 218491009672 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009673 exoribonuclease II; Provisional; Region: PRK05054 218491009674 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 218491009675 RNB domain; Region: RNB; pfam00773 218491009676 S1 RNA binding domain; Region: S1; pfam00575 218491009677 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 0.0013 218491009678 PS01175 Ribonuclease II family signature. 218491009679 HMMPfam hit to PF00773, DE RNB-like protein, score 1.6e-103 218491009680 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 218491009681 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 218491009682 putative molybdopterin cofactor binding site [chemical binding]; other site 218491009683 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 218491009684 putative molybdopterin cofactor binding site; other site 218491009685 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 0.00011 218491009686 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 2.8e-12 218491009687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491009688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491009689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491009690 dimerization interface [polypeptide binding]; other site 218491009691 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.1e-14 218491009692 Predicted helix-turn-helix motif with score 1297.000, SD 3.60 at aa 16-37, sequence RHFGRAAEASFVSQPTLSMRLK 218491009693 PS00044 Bacterial regulatory proteins, lysR family signature. 218491009694 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 9e-24 218491009695 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491009696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491009697 DNA binding site [nucleotide binding] 218491009698 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 218491009699 ligand binding site [chemical binding]; other site 218491009700 dimerization interface [polypeptide binding]; other site 218491009701 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.00039 218491009702 Predicted helix-turn-helix motif with score 1945.000, SD 5.81 at aa 5-26, sequence LKIREIAQRTGYSISTVSRVLS 218491009703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491009704 D-galactonate transporter; Region: 2A0114; TIGR00893 218491009705 putative substrate translocation pore; other site 218491009706 10 probable transmembrane helices predicted for ECA1967 by TMHMM2.0 at aa 21-38, 90-112, 148-170, 180-199, 241-263, 278-300, 312-334, 339-361, 381-398 and 403-425 218491009707 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0011 218491009708 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 218491009709 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 218491009710 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 218491009711 putative active site [active] 218491009712 putative catalytic site [active] 218491009713 HMMPfam hit to PF01055, DE Glycosyl hydrolases family 31, score 2e-49 218491009714 PS00066 Hydroxymethylglutaryl-coenzyme A reductases signature 1. 218491009715 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491009716 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 218491009717 putative active site [active] 218491009718 putative FMN binding site [chemical binding]; other site 218491009719 putative substrate binding site [chemical binding]; other site 218491009720 putative catalytic residue [active] 218491009721 FMN-binding domain; Region: FMN_bind; cl01081 218491009722 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 218491009723 L-aspartate oxidase; Provisional; Region: PRK06175 218491009724 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 1.9e-88 218491009725 HMMPfam hit to PF00890, DE FAD binding domain, score 1.5e-15 218491009726 Predicted helix-turn-helix motif with score 995.000, SD 2.58 at aa 799-820, sequence SSVTELADKLDMPQVALQATFE 218491009727 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 218491009728 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 218491009729 ApbE family; Region: ApbE; pfam02424 218491009730 HMMPfam hit to PF02424, DE ApbE family, score 1.4e-41 218491009731 Inclusion body protein; Region: PixA; pfam12306 218491009732 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 218491009733 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 218491009734 NAD binding site [chemical binding]; other site 218491009735 homotetramer interface [polypeptide binding]; other site 218491009736 homodimer interface [polypeptide binding]; other site 218491009737 substrate binding site [chemical binding]; other site 218491009738 active site 218491009739 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 3.5e-12 218491009740 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 218491009741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491009742 Walker A/P-loop; other site 218491009743 ATP binding site [chemical binding]; other site 218491009744 Q-loop/lid; other site 218491009745 ABC transporter signature motif; other site 218491009746 Walker B; other site 218491009747 D-loop; other site 218491009748 H-loop/switch region; other site 218491009749 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491009750 HMMPfam hit to PF00005, DE ABC transporter, score 9.5e-59 218491009751 PS00211 ABC transporters family signature. 218491009752 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009753 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 218491009754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491009755 Walker A/P-loop; other site 218491009756 ATP binding site [chemical binding]; other site 218491009757 Q-loop/lid; other site 218491009758 ABC transporter signature motif; other site 218491009759 Walker B; other site 218491009760 D-loop; other site 218491009761 H-loop/switch region; other site 218491009762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491009763 HMMPfam hit to PF00005, DE ABC transporter, score 1.8e-62 218491009764 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009765 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 218491009766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491009767 dimer interface [polypeptide binding]; other site 218491009768 conserved gate region; other site 218491009769 putative PBP binding loops; other site 218491009770 ABC-ATPase subunit interface; other site 218491009771 6 probable transmembrane helices predicted for ECA1975 by TMHMM2.0 at aa 28-50, 99-121, 134-156, 195-217, 224-246 and 261-283 218491009772 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.7e-06 218491009773 Signal peptide predicted for ECA1976 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.689 between residues 27 and 28; signal peptide 218491009774 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 218491009775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491009776 putative PBP binding loops; other site 218491009777 dimer interface [polypeptide binding]; other site 218491009778 ABC-ATPase subunit interface; other site 218491009779 5 probable transmembrane helices predicted for ECA1976 by TMHMM2.0 at aa 9-31, 80-102, 109-131, 251-273 and 286-308 218491009780 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 5.8e-10 218491009781 Signal peptide predicted for ECA1977 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 20 and 21; signal peptide 218491009782 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218491009783 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 218491009784 peptide binding site [polypeptide binding]; other site 218491009785 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 1.5e-201 218491009786 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 218491009787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491009788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491009789 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218491009790 putative effector binding pocket; other site 218491009791 putative dimerization interface [polypeptide binding]; other site 218491009792 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.4e-42 218491009793 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 7e-22 218491009794 PS00044 Bacterial regulatory proteins, lysR family signature. 218491009795 Predicted helix-turn-helix motif with score 2056.000, SD 6.19 at aa 19-40, sequence RSFRRAADLSGVTRSTLSHAIC 218491009796 short chain dehydrogenase; Provisional; Region: PRK06482 218491009797 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 218491009798 NADP binding site [chemical binding]; other site 218491009799 active site 218491009800 steroid binding site; other site 218491009801 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 4e-45 218491009802 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491009803 Signal peptide predicted for ECA1981 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.975 between residues 31 and 32; signal peptide 218491009804 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 218491009805 Cellulose binding domain; Region: CBM_3; pfam00942 218491009806 HMMPfam hit to PF00150, DE Cellulase (glycosyl hydrolase family 5), score 2.8e-95 218491009807 PS00659 Glycosyl hydrolases family 5 signature. 218491009808 HMMPfam hit to PF00942, DE Cellulose binding domain, score 8.7e-31 218491009809 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 218491009810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491009811 Walker A motif; other site 218491009812 ATP binding site [chemical binding]; other site 218491009813 Walker B motif; other site 218491009814 arginine finger; other site 218491009815 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218491009816 HMMPfam hit to PF02954, DE Bacterial regulatory protein, Fis family, score 4.9e-06 218491009817 Predicted helix-turn-helix motif with score 1599.000, SD 4.63 at aa 300-321, sequence FNQRKAAELLGLTYHQLRGLLK 218491009818 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491009819 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 7.4e-103 218491009820 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491009821 phage shock protein PspA; Provisional; Region: PRK10698 218491009822 phage shock protein B; Provisional; Region: pspB; PRK09458 218491009823 1 probable transmembrane helix predicted for ECA1984 by TMHMM2.0 at aa 4-26 218491009824 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 218491009825 phage shock protein C; Region: phageshock_pspC; TIGR02978 218491009826 1 probable transmembrane helix predicted for ECA1985 by TMHMM2.0 at aa 39-61 218491009827 Predicted ATPase [General function prediction only]; Region: COG3106 218491009828 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009829 hypothetical protein; Provisional; Region: PRK05415 218491009830 Domain of unknown function (DUF697); Region: DUF697; cl12064 218491009831 3 probable transmembrane helices predicted for ECA1987 by TMHMM2.0 at aa 65-84, 99-121 and 211-233 218491009832 Signal peptide predicted for ECA1988 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 25 and 26; signal peptide 218491009833 hypothetical protein; Provisional; Region: PRK06446 218491009834 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 218491009835 putative metal binding site [ion binding]; other site 218491009836 putative dimer interface [polypeptide binding]; other site 218491009837 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 6e-27 218491009838 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 218491009839 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 218491009840 putative aromatic amino acid binding site; other site 218491009841 PAS domain; Region: PAS; smart00091 218491009842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491009843 Walker A motif; other site 218491009844 ATP binding site [chemical binding]; other site 218491009845 Walker B motif; other site 218491009846 arginine finger; other site 218491009847 HMMPfam hit to PF01842, DE ACT domain, score 0.00073 218491009848 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 3.6e-130 218491009849 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491009850 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491009851 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491009852 Predicted helix-turn-helix motif with score 1684.000, SD 4.92 at aa 486-507, sequence PSTRKLAKRLGVSHTAIANKLR 218491009853 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 218491009854 dimer interface [polypeptide binding]; other site 218491009855 catalytic triad [active] 218491009856 peroxidatic and resolving cysteines [active] 218491009857 HMMPfam hit to PF00578, DE AhpC/TSA family, score 1.2e-30 218491009858 PS01265 Tpx family signature. 218491009859 murein peptide amidase A; Provisional; Region: PRK10602 218491009860 active site 218491009861 Zn binding site [ion binding]; other site 218491009862 Signal peptide predicted for ECA1992 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 22 and 23; signal peptide 218491009863 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 218491009864 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218491009865 peptide binding site [polypeptide binding]; other site 218491009866 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 3.6e-148 218491009867 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 218491009868 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 218491009869 Cl binding site [ion binding]; other site 218491009870 oligomer interface [polypeptide binding]; other site 218491009871 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01544, DE CorA-like Mg2+ transporter protein, score 2.4e-09 218491009872 2 probable transmembrane helices predicted for ECA1993 by TMHMM2.0 at aa 272-294 and 299-321 218491009873 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 218491009874 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 218491009875 Ligand Binding Site [chemical binding]; other site 218491009876 HMMPfam hit to PF01171, DE PP-loop family, score 7.4e-05 218491009877 Colicin C terminal ribonuclease domain; Region: Colicin_C; pfam12106 218491009878 Colicin-E5 Imm protein; Region: ImmE5; pfam11480 218491009879 Signal peptide predicted for ECA1999 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.971 between residues 25 and 26; signal peptide 218491009880 Domain of unknown function (DUF333); Region: DUF333; pfam03891 218491009881 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009882 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 218491009883 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 218491009884 putative ligand binding site [chemical binding]; other site 218491009885 putative NAD binding site [chemical binding]; other site 218491009886 catalytic site [active] 218491009887 HMMPfam hit to PF02826, DE D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 2.1e-96 218491009888 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 218491009889 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 218491009890 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 218491009891 HMMPfam hit to PF00389, DE D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 3e-27 218491009892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491009893 PAS domain; Region: PAS_9; pfam13426 218491009894 putative active site [active] 218491009895 heme pocket [chemical binding]; other site 218491009896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218491009897 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491009898 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491009899 dimer interface [polypeptide binding]; other site 218491009900 putative CheW interface [polypeptide binding]; other site 218491009901 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 7.8e-66 218491009902 HMMPfam hit to PF00672, DE HAMP domain, score 0.0085 218491009903 2 probable transmembrane helices predicted for ECA2001 by TMHMM2.0 at aa 143-165 and 172-194 218491009904 HMMPfam hit to PF00785, DE PAC motif, score 1.1e-05 218491009905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491009906 PAS domain; Region: PAS_9; pfam13426 218491009907 putative active site [active] 218491009908 heme pocket [chemical binding]; other site 218491009909 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491009910 HAMP domain; Region: HAMP; pfam00672 218491009911 dimerization interface [polypeptide binding]; other site 218491009912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491009913 dimer interface [polypeptide binding]; other site 218491009914 putative CheW interface [polypeptide binding]; other site 218491009915 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 6e-58 218491009916 HMMPfam hit to PF00672, DE HAMP domain, score 0.0053 218491009917 1 probable transmembrane helix predicted for ECA2002 by TMHMM2.0 at aa 171-193 218491009918 HMMPfam hit to PF00785, DE PAC motif, score 0.066 218491009919 Signal peptide predicted for ECA2003 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.672 between residues 22 and 23; signal peptide 218491009920 hypothetical protein; Provisional; Region: PRK10695 218491009921 1 probable transmembrane helix predicted for ECA2003 by TMHMM2.0 at aa 7-24 218491009922 Signal peptide predicted for ECA2004 by SignalP 2.0 HMM (Signal peptide probabilty 0.869) with cleavage site probability 0.841 between residues 26 and 27; signal peptide 218491009923 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 218491009924 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009925 azoreductase; Reviewed; Region: PRK00170 218491009926 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218491009927 HMMPfam hit to PF02525, DE Flavodoxin-like fold, score 1.8e-54 218491009928 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 218491009929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491009930 ATP binding site [chemical binding]; other site 218491009931 putative Mg++ binding site [ion binding]; other site 218491009932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491009933 nucleotide binding region [chemical binding]; other site 218491009934 ATP-binding site [chemical binding]; other site 218491009935 Helicase associated domain (HA2); Region: HA2; pfam04408 218491009936 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 218491009937 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 218491009938 PS00017 ATP/GTP-binding site motif A (P-loop). 218491009939 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 4.9e-10 218491009940 EcsC protein family; Region: EcsC; pfam12787 218491009941 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 218491009942 GAF domain; Region: GAF; pfam01590 218491009943 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491009944 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491009945 metal binding site [ion binding]; metal-binding site 218491009946 I-site; other site 218491009947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491009948 HMMPfam hit to PF00563, DE EAL domain, score 5.6e-100 218491009949 HMMPfam hit to PF00990, DE GGDEF domain, score 0.068 218491009950 HMMPfam hit to PF01590, DE GAF domain, score 9.6e-10 218491009951 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 218491009952 Signal peptide predicted for ECA2009 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.986 between residues 20 and 21; signal peptide 218491009953 HMMPfam hit to PF00089, DE Trypsin, score 7.4e-05 218491009954 PS00135 Serine proteases, trypsin family, serine active site. 218491009955 PS00134 Serine proteases, trypsin family, histidine active site. 218491009956 Fimbrial protein; Region: Fimbrial; cl01416 218491009957 Signal peptide predicted for ECA2010 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.985 between residues 23 and 24; signal peptide 218491009958 Signal peptide predicted for ECA2011 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 22 and 23; signal peptide 218491009959 sensor protein RstB; Provisional; Region: PRK10604 218491009960 Signal peptide predicted for ECA2012 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.709 between residues 28 and 29; signal peptide 218491009961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491009962 dimerization interface [polypeptide binding]; other site 218491009963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491009964 dimer interface [polypeptide binding]; other site 218491009965 phosphorylation site [posttranslational modification] 218491009966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491009967 ATP binding site [chemical binding]; other site 218491009968 Mg2+ binding site [ion binding]; other site 218491009969 G-X-G motif; other site 218491009970 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.4e-30 218491009971 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 2.9e-09 218491009972 HMMPfam hit to PF00672, DE HAMP domain, score 7e-08 218491009973 2 probable transmembrane helices predicted for ECA2012 by TMHMM2.0 at aa 5-27 and 139-156 218491009974 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491009975 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 218491009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491009977 active site 218491009978 phosphorylation site [posttranslational modification] 218491009979 intermolecular recognition site; other site 218491009980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491009981 DNA binding site [nucleotide binding] 218491009982 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 2.9e-17 218491009983 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.9e-26 218491009984 Signal peptide predicted for ECA2015 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.992 between residues 20 and 21; signal peptide 218491009985 YceI-like domain; Region: YceI; pfam04264 218491009986 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 218491009987 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 218491009988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491009989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491009990 DNA binding residues [nucleotide binding] 218491009991 Predicted helix-turn-helix motif with score 1098.000, SD 2.93 at aa 113-134, sequence FTYQEAADTLSVPIGTIMSRLA 218491009992 HMMPfam hit to PF00776, , score 0.0011 218491009993 dihydromonapterin reductase; Provisional; Region: PRK06483 218491009994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491009995 NAD(P) binding site [chemical binding]; other site 218491009996 active site 218491009997 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.7e-13 218491009998 PS00061 Short-chain dehydrogenases/reductases family signature. 218491009999 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218491010001 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218491010002 PS00109 Tyrosine protein kinases specific active-site signature. 218491010003 putative transporter; Provisional; Region: PRK11660 218491010004 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 218491010005 Sulfate transporter family; Region: Sulfate_transp; pfam00916 218491010006 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 218491010007 HMMPfam hit to PF01740, DE STAS domain, score 4.4e-16 218491010008 HMMPfam hit to PF00916, DE Sulfate transporter family, score 4.1e-98 218491010009 10 probable transmembrane helices predicted for ECA2021 by TMHMM2.0 at aa 13-35, 55-74, 83-105, 130-152, 165-187, 233-255, 275-297, 307-324, 326-344 and 364-395 218491010010 PS00063 Aldo/keto reductase family active site signature. 218491010011 PS01130 Sulfate transporters signature. 218491010012 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 218491010013 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 218491010014 11 probable transmembrane helices predicted for ECA2022 by TMHMM2.0 at aa 13-31, 36-58, 71-93, 108-127, 134-156, 166-188, 219-238, 258-280, 291-313, 323-340 and 347-364 218491010015 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 218491010016 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 218491010017 FAD binding pocket [chemical binding]; other site 218491010018 FAD binding motif [chemical binding]; other site 218491010019 phosphate binding motif [ion binding]; other site 218491010020 NAD binding pocket [chemical binding]; other site 218491010021 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 218491010022 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 218491010023 putative active site pocket [active] 218491010024 dimerization interface [polypeptide binding]; other site 218491010025 putative catalytic residue [active] 218491010026 Signal peptide predicted for ECA2026 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.843 between residues 29 and 30; signal peptide 218491010027 Protein of unknown function, DUF481; Region: DUF481; pfam04338 218491010028 Acyltransferase family; Region: Acyl_transf_3; pfam01757 218491010029 10 probable transmembrane helices predicted for ECA2027 by TMHMM2.0 at aa 13-35, 50-72, 92-114, 167-189, 202-221, 236-258, 271-289, 294-316, 329-351 and 378-400 218491010030 HMMPfam hit to PF01757, DE Acyltransferase family, score 0.0022 218491010031 transcriptional regulator NarL; Provisional; Region: PRK10651 218491010032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491010033 active site 218491010034 phosphorylation site [posttranslational modification] 218491010035 intermolecular recognition site; other site 218491010036 dimerization interface [polypeptide binding]; other site 218491010037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491010038 DNA binding residues [nucleotide binding] 218491010039 dimerization interface [polypeptide binding]; other site 218491010040 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 6.3e-21 218491010041 PS00622 Bacterial regulatory proteins, luxR family signature. 218491010042 Predicted helix-turn-helix motif with score 1582.000, SD 4.58 at aa 171-192, sequence LSNKVIARKLTITESTVKVHVK 218491010043 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 3.5e-41 218491010044 Signal peptide predicted for ECA2029 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.484 between residues 36 and 37; signal peptide 218491010045 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 218491010046 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 218491010047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491010048 dimerization interface [polypeptide binding]; other site 218491010049 Histidine kinase; Region: HisKA_3; pfam07730 218491010050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491010051 ATP binding site [chemical binding]; other site 218491010052 Mg2+ binding site [ion binding]; other site 218491010053 G-X-G motif; other site 218491010054 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491010055 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.6e-19 218491010056 HMMPfam hit to PF00672, DE HAMP domain, score 8.4e-15 218491010057 2 probable transmembrane helices predicted for ECA2029 by TMHMM2.0 at aa 36-58 and 173-195 218491010058 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 218491010059 12 probable transmembrane helices predicted for ECA2030 by TMHMM2.0 at aa 39-61, 76-98, 105-123, 133-155, 176-198, 213-235, 256-278, 288-307, 320-339, 354-376, 404-426 and 436-458 218491010060 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 218491010061 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 218491010062 [4Fe-4S] binding site [ion binding]; other site 218491010063 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218491010064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218491010065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 218491010066 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 218491010067 molybdopterin cofactor binding site; other site 218491010068 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 218491010069 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 1.3e-184 218491010070 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 218491010071 PS00037 Myb DNA-binding domain repeat signature 1. 218491010072 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 2.9e-40 218491010073 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 218491010074 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.09 218491010075 PS00190 Cytochrome c family heme-binding site signature. 218491010076 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.098 218491010077 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 218491010078 HMMPfam hit to PF02613, DE Nitrate reductase delta subunit, score 3.7e-69 218491010079 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 218491010080 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02665, DE Nitrate reductase gamma subunit, score 2.7e-107 218491010081 5 probable transmembrane helices predicted for ECA2034 by TMHMM2.0 at aa 15-37, 62-84, 99-118, 131-153 and 185-207 218491010082 EamA-like transporter family; Region: EamA; pfam00892 218491010083 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218491010084 EamA-like transporter family; Region: EamA; pfam00892 218491010085 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 3.4e-20 218491010086 10 probable transmembrane helices predicted for ECA2035 by TMHMM2.0 at aa 13-30, 40-57, 70-92, 96-115, 122-139, 149-168, 175-197, 207-229, 236-258 and 263-282 218491010087 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 2.4e-12 218491010088 MarR family; Region: MarR_2; cl17246 218491010089 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218491010090 HMMPfam hit to PF01047, DE MarR family, score 2.8e-19 218491010091 OsmC-like protein; Region: OsmC; cl00767 218491010092 HMMPfam hit to PF02566, DE OsmC-like protein, score 3.6e-08 218491010093 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010094 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 218491010095 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 218491010096 dimer interface [polypeptide binding]; other site 218491010097 active site 218491010098 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491010099 substrate binding site [chemical binding]; other site 218491010100 catalytic residue [active] 218491010101 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 218491010102 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 218491010103 HMMPfam hit to PF02423, DE Ornithine cyclodeaminase/mu-crystallin family, score 3.6e-62 218491010104 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 218491010105 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218491010106 tetramer interface [polypeptide binding]; other site 218491010107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010108 catalytic residue [active] 218491010109 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 5.2e-90 218491010110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 218491010111 YheO-like PAS domain; Region: PAS_6; pfam08348 218491010112 HTH domain; Region: HTH_22; pfam13309 218491010113 Predicted helix-turn-helix motif with score 1277.000, SD 3.54 at aa 185-206, sequence KSMETIAQHLGVSRASVYLYAK 218491010114 hypothetical protein; Provisional; Region: PRK10457 218491010115 3 probable transmembrane helices predicted for ECA2044 by TMHMM2.0 at aa 56-78, 88-110 and 115-134 218491010116 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 218491010117 extended (e) SDRs; Region: SDR_e; cd08946 218491010118 NAD(P) binding site [chemical binding]; other site 218491010119 active site 218491010120 substrate binding site [chemical binding]; other site 218491010121 HMMPfam hit to PF01370, DE NAD dependent epimerase/dehydratase family, score 4.5e-14 218491010122 1 probable transmembrane helix predicted for ECA2045 by TMHMM2.0 at aa 5-27 218491010123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218491010124 active site 218491010125 C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin; Region: Chitin_synth_C; cd04190 218491010126 DXD motif; other site 218491010127 Colicin V production protein; Region: Colicin_V; pfam02674 218491010128 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218491010129 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 218491010130 inhibitor-cofactor binding pocket; inhibition site 218491010131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010132 catalytic residue [active] 218491010133 HMMPfam hit to PF01041, DE DegT/DnrJ/EryC1/StrS aminotransferase family, score 9.5e-82 218491010134 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 218491010135 7 probable transmembrane helices predicted for ECA2046 by TMHMM2.0 at aa 386-408, 423-445, 458-480, 484-506, 519-541, 571-590 and 597-619 218491010136 HMMPfam hit to PF01644, DE Chitin synthase, score 1.2e-05 218491010137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 218491010138 Signal peptide predicted for ECA2047 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.790 between residues 31 and 32; signal peptide 218491010139 Predicted helix-turn-helix motif with score 989.000, SD 2.56 at aa 200-221, sequence TTAAQHILRLMESTSTISRRIQ 218491010140 Signal peptide predicted for ECA2048 by SignalP 2.0 HMM (Signal peptide probabilty 0.856) with cleavage site probability 0.813 between residues 54 and 55; signal peptide 218491010141 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 218491010142 Signal peptide predicted for ECA2050 by SignalP 2.0 HMM (Signal peptide probabilty 0.849) with cleavage site probability 0.394 between residues 24 and 25; signal peptide 218491010143 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 218491010144 6 probable transmembrane helices predicted for ECA2050 by TMHMM2.0 at aa 5-27, 40-62, 67-89, 110-132, 147-169 and 182-204 218491010145 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 218491010146 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 218491010147 Walker A/P-loop; other site 218491010148 ATP binding site [chemical binding]; other site 218491010149 Q-loop/lid; other site 218491010150 ABC transporter signature motif; other site 218491010151 Walker B; other site 218491010152 D-loop; other site 218491010153 H-loop/switch region; other site 218491010154 TOBE domain; Region: TOBE_2; pfam08402 218491010155 HMMPfam hit to PF00005, DE ABC transporter, score 9.9e-65 218491010156 PS00211 ABC transporters family signature. 218491010157 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010158 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491010159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491010160 DNA-binding site [nucleotide binding]; DNA binding site 218491010161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491010162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010163 homodimer interface [polypeptide binding]; other site 218491010164 catalytic residue [active] 218491010165 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 3e-13 218491010166 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 218491010167 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491010168 inhibitor-cofactor binding pocket; inhibition site 218491010169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010170 catalytic residue [active] 218491010171 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00202, DE Aminotransferase class-III, score 8e-156 218491010172 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491010173 succinic semialdehyde dehydrogenase; Region: PLN02278 218491010174 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 218491010175 tetramerization interface [polypeptide binding]; other site 218491010176 NAD(P) binding site [chemical binding]; other site 218491010177 catalytic residues [active] 218491010178 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 2e-208 218491010179 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 196-217, sequence LALAELAQQAGIPRGVLQVIVG 218491010180 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491010181 PS00070 Aldehyde dehydrogenases cysteine active site. 218491010182 Signal peptide predicted for ECA2055 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.988 between residues 37 and 38; signal peptide 218491010183 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 218491010184 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 218491010185 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010186 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 1.1e-15 218491010187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491010188 dimer interface [polypeptide binding]; other site 218491010189 conserved gate region; other site 218491010190 putative PBP binding loops; other site 218491010191 ABC-ATPase subunit interface; other site 218491010192 6 probable transmembrane helices predicted for ECA2056 by TMHMM2.0 at aa 36-58, 207-229, 236-258, 289-311, 344-366 and 388-410 218491010193 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 7.4e-07 218491010194 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491010195 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218491010196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491010197 dimer interface [polypeptide binding]; other site 218491010198 conserved gate region; other site 218491010199 putative PBP binding loops; other site 218491010200 ABC-ATPase subunit interface; other site 218491010201 6 probable transmembrane helices predicted for ECA2057 by TMHMM2.0 at aa 13-35, 74-96, 108-129, 139-161, 181-203 and 239-261 218491010202 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.6e-10 218491010203 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491010204 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 218491010205 classical (c) SDRs; Region: SDR_c; cd05233 218491010206 NAD(P) binding site [chemical binding]; other site 218491010207 active site 218491010208 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 3.2e-57 218491010209 PS00061 Short-chain dehydrogenases/reductases family signature. 218491010210 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 218491010211 active site 218491010212 ATP binding site [chemical binding]; other site 218491010213 Phosphotransferase enzyme family; Region: APH; pfam01636 218491010214 substrate binding site [chemical binding]; other site 218491010215 HMMPfam hit to PF01636, DE Phosphotransferase enzyme family, score 0.0011 218491010216 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 218491010217 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491010218 inhibitor-cofactor binding pocket; inhibition site 218491010219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010220 catalytic residue [active] 218491010221 HMMPfam hit to PF00202, DE Aminotransferase class-III, score 1.3e-75 218491010222 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491010223 Signal peptide predicted for ECA2061 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.472 between residues 24 and 25; signal peptide 218491010224 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491010225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491010226 dimerization interface [polypeptide binding]; other site 218491010227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491010228 dimer interface [polypeptide binding]; other site 218491010229 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 218491010230 putative CheW interface [polypeptide binding]; other site 218491010231 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.1e-91 218491010232 HMMPfam hit to PF00672, DE HAMP domain, score 7.5e-13 218491010233 2 probable transmembrane helices predicted for ECA2061 by TMHMM2.0 at aa 10-29 and 183-205 218491010234 Signal peptide predicted for ECA2062 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.710 between residues 28 and 29; signal peptide 218491010235 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 218491010236 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 218491010237 active site 218491010238 HMMPfam hit to PF01569, DE PAP2 superfamily, score 0.0032 218491010239 Predicted helix-turn-helix motif with score 1382.000, SD 3.89 at aa 76-97, sequence LTRAQLAQAQETSQMADINWLN 218491010240 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 218491010241 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 218491010242 Walker A/P-loop; other site 218491010243 ATP binding site [chemical binding]; other site 218491010244 Q-loop/lid; other site 218491010245 ABC transporter signature motif; other site 218491010246 Walker B; other site 218491010247 D-loop; other site 218491010248 H-loop/switch region; other site 218491010249 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491010250 NIL domain; Region: NIL; pfam09383 218491010251 HMMPfam hit to PF00005, DE ABC transporter, score 4.2e-65 218491010252 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010253 PS00211 ABC transporters family signature. 218491010254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491010255 dimer interface [polypeptide binding]; other site 218491010256 conserved gate region; other site 218491010257 ABC-ATPase subunit interface; other site 218491010258 5 probable transmembrane helices predicted for ECA2064 by TMHMM2.0 at aa 22-44, 56-78, 88-110, 151-173 and 193-215 218491010259 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 6.9e-13 218491010260 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491010261 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 218491010262 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 218491010263 active site 218491010264 octamer interface [polypeptide binding]; other site 218491010265 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 4.3e-10 218491010266 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 2.3e-17 218491010267 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 218491010268 Signal peptide predicted for ECA2066 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 20 and 21; signal peptide 218491010269 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 218491010270 HMMPfam hit to PF03180, DE NLPA lipoprotein, score 1.1e-93 218491010271 Bor protein; Region: Lambda_Bor; pfam06291 218491010272 Signal peptide predicted for ECA2067 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.282 between residues 23 and 24; signal peptide 218491010273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010274 Amino acid permease; Region: AA_permease_2; pfam13520 218491010275 HMMPfam hit to PF00324, DE Amino acid permease, score 0.00013 218491010276 12 probable transmembrane helices predicted for ECA2068 by TMHMM2.0 at aa 28-50, 60-82, 102-124, 139-161, 168-190, 210-232, 245-267, 299-321, 345-367, 382-404, 411-433 and 448-470 218491010277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491010278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491010279 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 3.7e-05 218491010280 Predicted helix-turn-helix motif with score 1475.000, SD 4.21 at aa 59-80, sequence VSMRSLAKAVDLKPPTMYSHFP 218491010281 Signal peptide predicted for ECA2070 by SignalP 2.0 HMM (Signal peptide probabilty 0.820) with cleavage site probability 0.502 between residues 33 and 34; signal peptide 218491010282 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491010283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491010284 putative substrate translocation pore; other site 218491010285 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 4.2e-05 218491010286 12 probable transmembrane helices predicted for ECA2070 by TMHMM2.0 at aa 13-32, 52-74, 81-103, 113-132, 144-166, 170-192, 213-235, 245-267, 274-296, 300-322, 342-364 and 368-385 218491010287 PS00012 Phosphopantetheine attachment site. 218491010288 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 218491010289 Cytochrome P450; Region: p450; cl12078 218491010290 HMMPfam hit to PF00067, DE Cytochrome P450, score 1.1e-07 218491010291 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 218491010292 Flavodoxin; Region: Flavodoxin_1; pfam00258 218491010293 HMMPfam hit to PF00258, DE Flavodoxin, score 8.4e-28 218491010294 ferredoxin-NADP+ reductase; Region: PLN02852 218491010295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491010296 hypothetical protein; Provisional; Region: PRK07079 218491010297 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 218491010298 metal binding site [ion binding]; metal-binding site 218491010299 putative dimer interface [polypeptide binding]; other site 218491010300 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 8.2e-25 218491010301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491010302 Signal peptide predicted for ECA2075 by SignalP 2.0 HMM (Signal peptide probabilty 0.876) with cleavage site probability 0.399 between residues 27 and 28; signal peptide 218491010303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491010304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491010305 dimerization interface [polypeptide binding]; other site 218491010306 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.5e-22 218491010307 Predicted helix-turn-helix motif with score 1376.000, SD 3.87 at aa 16-37, sequence GSLSAASQHLFVAVSAISRQIQ 218491010308 PS00044 Bacterial regulatory proteins, lysR family signature. 218491010309 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 3.3e-28 218491010310 Harpin type III secretion system 218491010311 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 218491010312 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 218491010313 HMMPfam hit to PF01312, DE FlhB HrpN YscU SpaS Family, score 6.2e-152 218491010314 1 probable transmembrane helix predicted for ECA2076 by TMHMM2.0 at aa 78-100 218491010315 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 218491010316 HMMPfam hit to PF01311, DE Bacterial export proteins, family 1, score 7.8e-87 218491010317 6 probable transmembrane helices predicted for ECA2077 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 133-152, 187-209 and 216-238 218491010318 Signal peptide predicted for ECA2078 by SignalP 2.0 HMM (Signal peptide probabilty 0.928) with cleavage site probability 0.482 between residues 24 and 25; signal peptide 218491010319 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 218491010320 HMMPfam hit to PF01313, DE Bacterial export proteins, family 3, score 5.1e-35 218491010321 2 probable transmembrane helices predicted for ECA2078 by TMHMM2.0 at aa 13-35 and 45-67 218491010322 type III secretion system protein YscR; Provisional; Region: PRK12797 218491010323 HMMPfam hit to PF00813, DE FliP family, score 6.4e-114 218491010324 4 probable transmembrane helices predicted for ECA2079 by TMHMM2.0 at aa 10-32, 53-72, 158-180 and 187-209 218491010325 PS01061 Flagella transport protein fliP family signature 2. 218491010326 PS01060 Flagella transport protein fliP family signature 1. 218491010327 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 218491010328 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 218491010329 HMMPfam hit to PF01052, DE Surface presentation of antigens (SPOA) protein, score 3.4e-11 218491010330 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 218491010331 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 218491010332 Walker A motif; other site 218491010333 ATP binding site [chemical binding]; other site 218491010334 Walker B motif; other site 218491010335 HMMPfam hit to PF00006, DE ATP synthase alpha/beta family, nucleotide-binding domain, score 3.7e-131 218491010336 PS00152 ATP synthase alpha and beta subunits signature. 218491010337 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010338 HMMPfam hit to PF02874, DE ATP synthase alpha/beta family, beta-barrel domain, score 8.3e-05 218491010339 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 218491010340 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 218491010341 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 218491010342 FHIPEP family; Region: FHIPEP; pfam00771 218491010343 HMMPfam hit to PF00771, DE FHIPEP family, score 0 218491010344 7 probable transmembrane helices predicted for ECA2085 by TMHMM2.0 at aa 21-38, 42-64, 69-91, 111-133, 203-225, 245-267 and 293-315 218491010345 PS00994 Bacterial export FHIPEP family signature. 218491010346 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 218491010347 TyeA; Region: TyeA; cl07611 218491010348 1 probable transmembrane helix predicted for ECA2086 by TMHMM2.0 at aa 30-52 218491010349 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 218491010350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491010351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491010352 DNA binding residues [nucleotide binding] 218491010353 HMMPfam hit to PF00776, , score 1.8e-19 218491010354 Predicted helix-turn-helix motif with score 1291.000, SD 3.58 at aa 147-168, sequence ASYQDLALQLGIPIGTVRSRLS 218491010355 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491010357 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 218491010358 putative active site [active] 218491010359 heme pocket [chemical binding]; other site 218491010360 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 218491010361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491010362 putative active site [active] 218491010363 heme pocket [chemical binding]; other site 218491010364 Histidine kinase; Region: HisKA_3; pfam07730 218491010365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491010366 ATP binding site [chemical binding]; other site 218491010367 Mg2+ binding site [ion binding]; other site 218491010368 G-X-G motif; other site 218491010369 HMMPfam hit to PF00989, DE PAS domain, score 8.2e-05 218491010370 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.7e-07 218491010371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218491010372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491010373 active site 218491010374 phosphorylation site [posttranslational modification] 218491010375 intermolecular recognition site; other site 218491010376 dimerization interface [polypeptide binding]; other site 218491010377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491010378 DNA binding residues [nucleotide binding] 218491010379 dimerization interface [polypeptide binding]; other site 218491010380 PS00430 TonB-dependent receptor proteins signature 1. 218491010381 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 4.2e-36 218491010382 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 1.3e-12 218491010383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491010384 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 218491010385 Walker A motif; other site 218491010386 ATP binding site [chemical binding]; other site 218491010387 Walker B motif; other site 218491010388 arginine finger; other site 218491010389 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218491010390 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 2.2e-97 218491010391 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491010392 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491010393 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491010394 Predicted helix-turn-helix motif with score 1050.000, SD 2.76 at aa 314-335, sequence HCIDDVIVELGIPKRTLYHRLK 218491010395 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 218491010396 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491010397 HMMPfam hit to PF00563, DE EAL domain, score 1.5e-71 218491010398 1 probable transmembrane helix predicted for ECA2091 by TMHMM2.0 at aa 23-45 218491010399 Type III secretion needle MxiH like; Region: MxiH; pfam09392 218491010400 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 218491010401 HMMPfam hit to PF01514, DE Secretory protein of YscJ/FliF family, score 5.7e-77 218491010402 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010403 1 probable transmembrane helix predicted for ECA2095 by TMHMM2.0 at aa 217-239 218491010404 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 218491010405 HrpF protein; Region: HrpF; pfam06266 218491010406 Signal peptide predicted for ECA2100 by SignalP 2.0 HMM (Signal peptide probabilty 0.924) with cleavage site probability 0.880 between residues 42 and 43; signal peptide 218491010407 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 218491010408 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218491010409 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218491010410 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218491010411 1 probable transmembrane helix predicted for ECA2100 by TMHMM2.0 at aa 20-42 218491010412 HMMPfam hit to PF03958, DE Bacterial type II/III secretion system short domain, score 6.2e-92 218491010413 HMMPfam hit to PF00263, DE Bacterial type II and III secretion system protein, score 2.6e-76 218491010414 Signal peptide predicted for ECA2101 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.254 between residues 24 and 25; signal peptide 218491010415 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010416 HrpZ; Region: Hairpins; pfam04877 218491010417 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218491010418 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218491010419 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218491010420 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 218491010421 PS00217 Sugar transport proteins signature 2. 218491010422 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 218491010423 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 218491010424 Signal peptide predicted for ECA2107 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.648 between residues 19 and 20; signal peptide 218491010425 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218491010426 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010427 Signal peptide predicted for ECA2108 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.577 between residues 19 and 20; signal peptide 218491010428 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218491010429 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010430 Signal peptide predicted for ECA2109 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.710 between residues 19 and 20; signal peptide 218491010431 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218491010432 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010433 PAAR motif; Region: PAAR_motif; pfam05488 218491010434 Pectate lyase; Region: Pectate_lyase; pfam03211 218491010435 HMMPfam hit to PF03211, DE Pectate lyase, score 8.8e-95 218491010436 Pathogenicity factor; Region: AvrE; pfam11725 218491010437 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491010438 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 218491010439 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 218491010440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491010441 DNA-binding site [nucleotide binding]; DNA binding site 218491010442 FCD domain; Region: FCD; pfam07729 218491010443 PS00043 Bacterial regulatory proteins, gntR family signature. 218491010444 Predicted helix-turn-helix motif with score 1060.000, SD 2.80 at aa 36-57, sequence LRIRELAAQVGTSVTPVRDAIL 218491010445 Signal peptide predicted for ECA2116 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 24 and 25; signal peptide 218491010446 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 218491010447 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 218491010448 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 218491010449 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03865, DE Hemolysin activator HlyB, score 4.6e-12 218491010450 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010451 Signal peptide predicted for ECA2117 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.785 between residues 29 and 30; signal peptide 218491010452 haemagglutination activity domain; Region: Haemagg_act; pfam05860 218491010453 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 218491010454 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 218491010455 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 218491010456 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 218491010457 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 218491010458 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218491010459 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491010460 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491010461 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 218491010462 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010463 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 218491010464 active site 218491010465 catalytic triad [active] 218491010466 dimer interface [polypeptide binding]; other site 218491010467 Predicted amidohydrolase [General function prediction only]; Region: COG0388 218491010468 Signal peptide predicted for ECA2134 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 28 and 29; signal peptide 218491010469 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 218491010470 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 0.018 218491010471 Signal peptide predicted for ECA2135 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 19 and 20; signal peptide 218491010472 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 218491010473 Signal peptide predicted for ECA2136 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.965 between residues 26 and 27; signal peptide 218491010474 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 218491010475 Signal peptide predicted for ECA2137 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 22 and 23; signal peptide 218491010476 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 218491010477 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010478 1 probable transmembrane helix predicted for ECA2138 by TMHMM2.0 at aa 10-28 218491010479 Signal peptide predicted for ECA2139 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.632 between residues 22 and 23; signal peptide 218491010480 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491010481 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491010482 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218491010483 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 6.7e-07 218491010484 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 0.13 218491010485 allophanate hydrolase; Provisional; Region: PRK08186 218491010486 Amidase; Region: Amidase; cl11426 218491010487 HMMPfam hit to PF01425, DE Amidase, score 7.2e-83 218491010488 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010489 urea carboxylase; Region: urea_carbox; TIGR02712 218491010490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218491010491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 218491010492 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 218491010493 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 218491010494 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 218491010495 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 218491010496 carboxyltransferase (CT) interaction site; other site 218491010497 biotinylation site [posttranslational modification]; other site 218491010498 HMMPfam hit to PF00289, DE Carbamoyl-phosphate synthase L chain, N-terminal domain, score 1.6e-39 218491010499 HMMPfam hit to PF02786, DE Carbamoyl-phosphate synthase L chain, ATP binding domain, score 2.2e-77 218491010500 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218491010501 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218491010502 HMMPfam hit to PF02785, DE Biotin carboxylase C-terminal domain, score 3.2e-53 218491010503 HMMPfam hit to PF02626, DE Allophanate hydrolase subunit 2, score 9.1e-121 218491010504 HMMPfam hit to PF02682, DE Allophanate hydrolase subunit 1, score 0.011 218491010505 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 8.2e-19 218491010506 PS00188 Biotin-requiring enzymes attachment site. 218491010507 Transcriptional regulators [Transcription]; Region: GntR; COG1802 218491010508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491010509 DNA-binding site [nucleotide binding]; DNA binding site 218491010510 FCD domain; Region: FCD; pfam07729 218491010511 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 6.7e-13 218491010512 Predicted helix-turn-helix motif with score 1318.000, SD 3.68 at aa 39-60, sequence FSESEIAERMSVSRTPVRQALF 218491010513 Signal peptide predicted for ECA2144 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.941 between residues 27 and 28; signal peptide 218491010514 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 218491010515 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 218491010516 putative ligand binding site [chemical binding]; other site 218491010517 Signal peptide predicted for ECA2145 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.943 between residues 23 and 24; signal peptide 218491010518 HEAT repeats; Region: HEAT_2; pfam13646 218491010519 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 218491010520 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491010521 TM-ABC transporter signature motif; other site 218491010522 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 2.3e-41 218491010523 7 probable transmembrane helices predicted for ECA2145 by TMHMM2.0 at aa 237-259, 289-311, 324-346, 370-392, 424-446, 461-483 and 490-509 218491010524 Signal peptide predicted for ECA2146 by SignalP 2.0 HMM (Signal peptide probabilty 0.882) with cleavage site probability 0.707 between residues 43 and 44; signal peptide 218491010525 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 218491010526 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 218491010527 TM-ABC transporter signature motif; other site 218491010528 9 probable transmembrane helices predicted for ECA2146 by TMHMM2.0 at aa 25-47, 52-74, 81-103, 134-156, 163-182, 211-233, 264-286, 301-323 and 336-358 218491010529 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 2.1e-26 218491010530 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 218491010531 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 218491010532 Walker A/P-loop; other site 218491010533 ATP binding site [chemical binding]; other site 218491010534 Q-loop/lid; other site 218491010535 ABC transporter signature motif; other site 218491010536 Walker B; other site 218491010537 D-loop; other site 218491010538 H-loop/switch region; other site 218491010539 HMMPfam hit to PF00005, DE ABC transporter, score 4.6e-42 218491010540 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010541 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 218491010542 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 218491010543 Walker A/P-loop; other site 218491010544 ATP binding site [chemical binding]; other site 218491010545 Q-loop/lid; other site 218491010546 ABC transporter signature motif; other site 218491010547 Walker B; other site 218491010548 D-loop; other site 218491010549 H-loop/switch region; other site 218491010550 HMMPfam hit to PF00005, DE ABC transporter, score 2.2e-47 218491010551 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010552 Signal peptide predicted for ECA2149 by SignalP 2.0 HMM (Signal peptide probabilty 0.954) with cleavage site probability 0.543 between residues 21 and 22; signal peptide 218491010553 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 218491010554 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 218491010555 2 probable transmembrane helices predicted for ECA2150 by TMHMM2.0 at aa 38-57 and 64-86 218491010556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491010557 H-loop/switch region; other site 218491010558 Methyltransferase domain; Region: Methyltransf_31; pfam13847 218491010559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491010560 S-adenosylmethionine binding site [chemical binding]; other site 218491010561 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491010562 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491010563 Walker A/P-loop; other site 218491010564 ATP binding site [chemical binding]; other site 218491010565 Q-loop/lid; other site 218491010566 ABC transporter signature motif; other site 218491010567 Walker B; other site 218491010568 D-loop; other site 218491010569 H-loop/switch region; other site 218491010570 HMMPfam hit to PF00005, DE ABC transporter, score 1.3e-66 218491010571 PS00211 ABC transporters family signature. 218491010572 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491010574 dimer interface [polypeptide binding]; other site 218491010575 conserved gate region; other site 218491010576 putative PBP binding loops; other site 218491010577 ABC-ATPase subunit interface; other site 218491010578 5 probable transmembrane helices predicted for ECA2154 by TMHMM2.0 at aa 33-52, 72-94, 114-136, 227-249 and 262-284 218491010579 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1e-12 218491010580 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491010581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491010582 Coenzyme A binding pocket [chemical binding]; other site 218491010583 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.1e-12 218491010584 Signal peptide predicted for ECA2156 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.945 between residues 44 and 45; signal peptide 218491010585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491010586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491010587 substrate binding pocket [chemical binding]; other site 218491010588 membrane-bound complex binding site; other site 218491010589 hinge residues; other site 218491010590 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 4.8e-38 218491010591 Signal peptide predicted for ECA2157 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 26 and 27; signal peptide 218491010592 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491010593 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491010594 substrate binding pocket [chemical binding]; other site 218491010595 membrane-bound complex binding site; other site 218491010596 hinge residues; other site 218491010597 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 6.2e-28 218491010598 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 218491010599 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 218491010600 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 218491010601 active site 218491010602 non-prolyl cis peptide bond; other site 218491010603 Flavin Reductases; Region: FlaRed; cl00801 218491010604 HMMPfam hit to PF01613, DE Flavin reductase like domain, score 2.8e-55 218491010605 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 218491010606 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 218491010607 metal binding site [ion binding]; metal-binding site 218491010608 dimer interface [polypeptide binding]; other site 218491010609 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 1.3e-80 218491010610 Predicted helix-turn-helix motif with score 1025.000, SD 2.68 at aa 53-74, sequence HQYPELSNQEHQTTAHITRWLQ 218491010611 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 218491010612 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 218491010613 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00296, DE Luciferase-like monooxygenase, score 5.3e-13 218491010614 Predicted helix-turn-helix motif with score 1200.000, SD 3.27 at aa 27-48, sequence VSLAKVAEALGYYRFWVSEHHN 218491010615 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 218491010616 Signal peptide predicted for ECA2163 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.999 between residues 23 and 24; signal peptide 218491010617 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 218491010618 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 218491010619 metal binding site [ion binding]; metal-binding site 218491010620 Autotransporter beta-domain; Region: Autotransporter; cl17461 218491010621 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03797, DE Autotransporter beta-domain, score 2.1e-25 218491010622 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491010623 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491010624 DNA binding site [nucleotide binding] 218491010625 domain linker motif; other site 218491010626 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218491010627 dimerization interface (closed form) [polypeptide binding]; other site 218491010628 ligand binding site [chemical binding]; other site 218491010629 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 7.8e-09 218491010630 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 8.1e-11 218491010631 Predicted helix-turn-helix motif with score 2147.000, SD 6.50 at aa 39-60, sequence STMQEVAKKAGVSKATVSRVLS 218491010632 PS00356 Bacterial regulatory proteins, lacI family signature. 218491010633 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 218491010634 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491010635 active site turn [active] 218491010636 phosphorylation site [posttranslational modification] 218491010637 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 218491010638 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 6.3e-16 218491010639 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491010640 8 probable transmembrane helices predicted for ECA2165 by TMHMM2.0 at aa 103-125, 145-167, 179-198, 213-235, 255-277, 292-314, 390-412 and 432-454 218491010641 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 2.6e-16 218491010642 Signal peptide predicted for ECA2166 by SignalP 2.0 HMM (Signal peptide probabilty 0.616) with cleavage site probability 0.228 between residues 17 and 18; signal peptide 218491010643 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 218491010644 beta-galactosidase; Region: BGL; TIGR03356 218491010645 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 2.2e-144 218491010646 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491010647 PS00572 Glycosyl hydrolases family 1 active site. 218491010648 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 218491010649 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 218491010650 active site 218491010651 HMMPfam hit to PF00459, DE Inositol monophosphatase family, score 2.7e-44 218491010652 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 218491010653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491010654 active site 218491010655 metal binding site [ion binding]; metal-binding site 218491010656 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00903, DE Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 5.4e-10 218491010657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218491010658 Zn2+ binding site [ion binding]; other site 218491010659 Mg2+ binding site [ion binding]; other site 218491010660 AAA domain; Region: AAA_33; pfam13671 218491010661 RNA ligase; Region: RNA_ligase; pfam09414 218491010662 Signal peptide predicted for ECA2172 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.956 between residues 23 and 24; signal peptide 218491010663 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 218491010664 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 218491010665 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 218491010666 Signal peptide predicted for ECA2175 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.944 between residues 22 and 23; signal peptide 218491010667 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 218491010668 Partial CDS. Similar to Escherichia coli Orf51 protein orf51 SWALL:Q9S116 (EMBL:AB024946) (523 aa) fasta scores: E(): 5.4e-43, 78.08% id in 146 aa, and to Shigella flexneri is orf s0216 or s0116 SWALL:Q99QK1 (EMBL:AF348706) (350 aa) fasta scores: E(): 5.8e-35, 64.38% id in 146 aa; transposase (partial) 218491010669 Low %GC DNA 218491010670 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491010671 DNA binding site [nucleotide binding] 218491010672 active site 218491010673 Int/Topo IB signature motif; other site 218491010674 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 218491010675 Family description; Region: UvrD_C_2; pfam13538 218491010676 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491010677 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010678 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 218491010679 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491010680 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 218491010681 active site 218491010682 Int/Topo IB signature motif; other site 218491010683 HMMPfam hit to PF00589, DE Phage integrase family, score 5.1e-19 218491010684 GTP-binding protein YchF; Reviewed; Region: PRK09601 218491010685 YchF GTPase; Region: YchF; cd01900 218491010686 G1 box; other site 218491010687 GTP/Mg2+ binding site [chemical binding]; other site 218491010688 Switch I region; other site 218491010689 G2 box; other site 218491010690 Switch II region; other site 218491010691 G3 box; other site 218491010692 G4 box; other site 218491010693 G5 box; other site 218491010694 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 218491010695 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010696 PS00443 Glutamine amidotransferases class-II active site. 218491010697 Signal peptide predicted for ECA2184 by SignalP 2.0 HMM (Signal peptide probabilty 0.640) with cleavage site probability 0.635 between residues 18 and 19; signal peptide 218491010698 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 218491010699 putative active site [active] 218491010700 catalytic residue [active] 218491010701 HMMPfam hit to PF01195, DE Peptidyl-tRNA hydrolase, score 5.9e-101 218491010702 PS00217 Sugar transport proteins signature 2. 218491010703 PS01196 Peptidyl-tRNA hydrolase signature 2. 218491010704 PS01195 Peptidyl-tRNA hydrolase signature 1. 218491010705 hypothetical protein; Provisional; Region: PRK10692 218491010706 Signal peptide predicted for ECA2185 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.979 between residues 30 and 31; signal peptide 218491010707 2 probable transmembrane helices predicted for ECA2185 by TMHMM2.0 at aa 7-29 and 44-61 218491010708 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 218491010709 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 218491010710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491010711 active site 218491010712 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 2.8e-36 218491010713 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491010714 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 218491010715 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491010716 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 218491010717 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 218491010718 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 218491010719 HMMPfam hit to PF00288, DE GHMP kinases ATP-binding protein, score 4.9e-30 218491010720 Signal peptide predicted for ECA2188 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.490 between residues 25 and 26; signal peptide 218491010721 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 218491010722 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 218491010723 HMMPfam hit to PF03550, DE Outer membrane lipoprotein LolB, score 8.1e-72 218491010724 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010725 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 218491010726 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 218491010727 tRNA; other site 218491010728 putative tRNA binding site [nucleotide binding]; other site 218491010729 putative NADP binding site [chemical binding]; other site 218491010730 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 218491010731 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00745, DE Glutamyl-tRNAGlu reductase, dimerisation domain, score 2e-231 218491010732 PS00747 Glutamyl-tRNA reductase signature. 218491010733 peptide chain release factor 1; Validated; Region: prfA; PRK00591 218491010734 This domain is found in peptide chain release factors; Region: PCRF; smart00937 218491010735 RF-1 domain; Region: RF-1; pfam00472 218491010736 HMMPfam hit to PF03462, DE PCRF domain, score 6.1e-71 218491010737 HMMPfam hit to PF00472, DE Peptidyl-tRNA hydrolase domain, score 1.7e-71 218491010738 PS00745 Prokaryotic-type class I peptide chain release factors signature. 218491010739 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 218491010740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491010741 PS00092 N-6 Adenine-specific DNA methylases signature. 218491010742 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 218491010743 4 probable transmembrane helices predicted for ECA2192 by TMHMM2.0 at aa 10-29, 41-63, 73-95 and 107-129 218491010744 hypothetical protein; Provisional; Region: PRK10941 218491010745 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 218491010746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 218491010747 binding surface 218491010748 TPR motif; other site 218491010749 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491010750 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 218491010751 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218491010752 HMMPfam hit to PF00793, DE DAHP synthetase I family, score 4.2e-120 218491010753 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 218491010754 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 218491010755 Signal peptide predicted for ECA2199 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.944 between residues 22 and 23; signal peptide 218491010756 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 218491010757 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010758 Signal peptide predicted for ECA2200 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.776 between residues 50 and 51; signal peptide 218491010759 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010760 Integrase core domain; Region: rve; pfam00665 218491010761 Integrase core domain; Region: rve_3; pfam13683 218491010762 HMMPfam hit to PF00665, DE Integrase core domain, score 1.1e-10 218491010763 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 218491010764 Signal peptide predicted for ECA2203 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 23 and 24; signal peptide 218491010765 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218491010766 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218491010767 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 218491010768 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 218491010769 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 218491010770 ligand binding site [chemical binding]; other site 218491010771 homodimer interface [polypeptide binding]; other site 218491010772 NAD(P) binding site [chemical binding]; other site 218491010773 trimer interface B [polypeptide binding]; other site 218491010774 trimer interface A [polypeptide binding]; other site 218491010775 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 218491010776 HMMPfam hit to PF01262, DE Alanine dehydrogenase/PNT, C-terminal domain, score 3.8e-78 218491010777 PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. 218491010778 5 probable transmembrane helices predicted for ECA2204 by TMHMM2.0 at aa 169-191, 402-419, 423-445, 452-471 and 476-498 218491010779 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. 218491010780 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 218491010781 Signal peptide predicted for ECA2205 by SignalP 2.0 HMM (Signal peptide probabilty 0.646) with cleavage site probability 0.247 between residues 44 and 45; signal peptide 218491010782 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 218491010783 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02233, DE NAD(P) transhydrogenase beta subunit, score 0 218491010784 9 probable transmembrane helices predicted for ECA2205 by TMHMM2.0 at aa 5-24, 33-52, 57-75, 88-107, 122-144, 165-184, 188-207, 214-236 and 240-259 218491010785 universal stress protein UspE; Provisional; Region: PRK11175 218491010786 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218491010787 Ligand Binding Site [chemical binding]; other site 218491010788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218491010789 Ligand Binding Site [chemical binding]; other site 218491010790 HMMPfam hit to PF00582, DE Universal stress protein family, score 2.8e-18 218491010791 HMMPfam hit to PF00582, DE Universal stress protein family, score 1.6e-11 218491010792 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 218491010793 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218491010794 ligand binding site [chemical binding]; other site 218491010795 flexible hinge region; other site 218491010796 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 218491010797 putative switch regulator; other site 218491010798 non-specific DNA interactions [nucleotide binding]; other site 218491010799 DNA binding site [nucleotide binding] 218491010800 sequence specific DNA binding site [nucleotide binding]; other site 218491010801 putative cAMP binding site [chemical binding]; other site 218491010802 HMMPfam hit to PF00325, DE Bacterial regulatory proteins, crp family, score 1.9e-13 218491010803 PS00042 Bacterial regulatory proteins, crp family signature. 218491010804 Predicted helix-turn-helix motif with score 1841.000, SD 5.46 at aa 195-216, sequence MTRGDIGNYLGLTVETISRLLG 218491010805 HMMPfam hit to PF00027, DE Cyclic nucleotide-binding domain, score 9.7e-20 218491010806 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 218491010807 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 218491010808 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218491010809 DNA binding site [nucleotide binding] 218491010810 active site 218491010811 HMMPfam hit to PF01035, DE 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 2.8e-46 218491010812 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 218491010813 HMMPfam hit to PF02870, DE 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain, score 1.1e-07 218491010814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491010815 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491010816 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218491010817 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 5.4e-22 218491010818 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 2.3e-12 218491010819 Signal peptide predicted for ECA2210 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.907 between residues 30 and 31; signal peptide 218491010820 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218491010821 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218491010822 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 2.9e-41 218491010823 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 218491010824 Signal peptide predicted for ECA2211 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.926 between residues 19 and 20; signal peptide 218491010825 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 218491010826 E-class dimer interface [polypeptide binding]; other site 218491010827 P-class dimer interface [polypeptide binding]; other site 218491010828 active site 218491010829 Cu2+ binding site [ion binding]; other site 218491010830 Zn2+ binding site [ion binding]; other site 218491010831 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00080, DE Copper/zinc superoxide dismutase (SODC), score 2.3e-45 218491010832 PS00332 Copper/Zinc superoxide dismutase signature 2. 218491010833 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010834 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 218491010835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491010836 S-adenosylmethionine binding site [chemical binding]; other site 218491010837 HMMPfam hit to PF02353, DE Cyclopropane-fatty-acyl-phospholipid synthase, score 2.4e-47 218491010838 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 218491010839 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 218491010840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 218491010841 HMMPfam hit to PF01593, DE Flavin containing amine oxidoreductase, score 1.5e-05 218491010842 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491010843 short chain dehydrogenase; Provisional; Region: PRK06101 218491010844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491010845 NAD(P) binding site [chemical binding]; other site 218491010846 active site 218491010847 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2.6e-21 218491010848 PS00061 Short-chain dehydrogenases/reductases family signature. 218491010849 SnoaL-like domain; Region: SnoaL_2; pfam12680 218491010850 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 218491010851 PS00017 ATP/GTP-binding site motif A (P-loop). 218491010852 Virulence factor SrfB; Region: SrfB; pfam07520 218491010853 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 218491010854 Signal peptide predicted for ECA2220 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24; signal peptide 218491010855 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 218491010856 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 218491010857 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02566, DE OsmC-like protein, score 1.8e-37 218491010858 Cytochrome b562; Region: Cytochrom_B562; pfam07361 218491010859 1 probable transmembrane helix predicted for ECA2222 by TMHMM2.0 at aa 31-50 218491010860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 218491010861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491010862 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 2.6e-09 218491010863 Predicted helix-turn-helix motif with score 1492.000, SD 4.27 at aa 35-56, sequence ATYRKIAQQAGLSPGTLTYRYS 218491010864 Signal peptide predicted for ECA2224 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.951 between residues 24 and 25; signal peptide 218491010865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491010866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491010867 12 probable transmembrane helices predicted for ECA2224 by TMHMM2.0 at aa 5-27, 47-69, 76-98, 102-124, 137-159, 163-182, 215-232, 247-269, 281-298, 308-330, 337-359 and 363-385 218491010868 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0062 218491010869 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218491010870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491010871 Coenzyme A binding pocket [chemical binding]; other site 218491010872 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.6e-11 218491010873 Cache domain; Region: Cache_1; pfam02743 218491010874 HAMP domain; Region: HAMP; pfam00672 218491010875 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491010876 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491010877 dimer interface [polypeptide binding]; other site 218491010878 putative CheW interface [polypeptide binding]; other site 218491010879 HMMPfam hit to PF02743, DE Cache domain, score 0.00012 218491010880 2 probable transmembrane helices predicted for ECA2226 by TMHMM2.0 at aa 30-52 and 330-352 218491010881 HMMPfam hit to PF00672, DE HAMP domain, score 1.2e-05 218491010882 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 7e-93 218491010883 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 218491010884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491010885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491010886 dimerization interface [polypeptide binding]; other site 218491010887 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.5e-19 218491010888 Predicted helix-turn-helix motif with score 2030.000, SD 6.10 at aa 18-39, sequence GSFEIAARKLHVTPSAISQRIK 218491010889 PS00044 Bacterial regulatory proteins, lysR family signature. 218491010890 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 0.00064 218491010891 hypothetical protein; Provisional; Region: PRK10515 218491010892 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491010893 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 218491010894 putative active site [active] 218491010895 putative FMN binding site [chemical binding]; other site 218491010896 putative substrate binding site [chemical binding]; other site 218491010897 putative catalytic residue [active] 218491010898 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 7.9e-74 218491010899 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 218491010900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491010901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491010902 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218491010903 putative effector binding pocket; other site 218491010904 putative dimerization interface [polypeptide binding]; other site 218491010905 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.1e-37 218491010906 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.2e-25 218491010907 PS00044 Bacterial regulatory proteins, lysR family signature. 218491010908 Predicted helix-turn-helix motif with score 1954.000, SD 5.84 at aa 19-40, sequence QSFTKAAAQLGVSQSALSYTIR 218491010909 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 218491010910 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 218491010911 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 218491010912 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 2.7e-24 218491010913 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 218491010914 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491010915 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491010916 HMMPfam hit to PF01638, DE Transcriptional regulator, score 1.2e-08 218491010917 SnoaL-like domain; Region: SnoaL_2; pfam12680 218491010918 FlxA-like protein; Region: FlxA; pfam14282 218491010919 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 218491010920 Signal peptide predicted for ECA2240 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.671 between residues 26 and 27; signal peptide 218491010921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 218491010922 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 218491010923 HMMPfam hit to PF02638, DE Uncharacterized BCR, COG1649, score 3.2e-213 218491010924 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010925 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 218491010926 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 218491010927 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 218491010928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491010929 inhibitor-cofactor binding pocket; inhibition site 218491010930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010931 catalytic residue [active] 218491010932 HMMPfam hit to PF00202, DE Aminotransferase class-III, score 1e-166 218491010933 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491010934 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 218491010935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010936 catalytic residue [active] 218491010937 HMMPfam hit to PF00282, DE Pyridoxal-dependent decarboxylase conserved domain, score 1.4e-35 218491010938 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 218491010939 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 218491010940 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 218491010941 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 218491010942 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 218491010943 conserved cys residue [active] 218491010944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491010945 HMMPfam hit to PF01965, DE DJ-1/PfpI family, score 0.00059 218491010946 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.6e-06 218491010947 Predicted helix-turn-helix motif with score 1153.000, SD 3.11 at aa 228-249, sequence HSLDALASRVQMSRRTFTRHFF 218491010948 PS00041 Bacterial regulatory proteins, araC family signature. 218491010949 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 8.4e-07 218491010950 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 218491010951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491010952 active site 218491010953 motif I; other site 218491010954 motif II; other site 218491010955 Predicted helix-turn-helix motif with score 1402.000, SD 3.96 at aa 120-141, sequence MSCAEIAEVTGLSEQDARRAQQ 218491010956 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 218491010957 Signal peptide predicted for ECA2250 by SignalP 2.0 HMM (Signal peptide probabilty 0.691) with cleavage site probability 0.691 between residues 56 and 57; signal peptide 218491010958 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 218491010959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491010960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491010961 homodimer interface [polypeptide binding]; other site 218491010962 catalytic residue [active] 218491010963 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 2.3e-12 218491010964 malonic semialdehyde reductase; Provisional; Region: PRK10538 218491010965 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 218491010966 putative NAD(P) binding site [chemical binding]; other site 218491010967 homodimer interface [polypeptide binding]; other site 218491010968 homotetramer interface [polypeptide binding]; other site 218491010969 active site 218491010970 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 9.5e-61 218491010971 PS00061 Short-chain dehydrogenases/reductases family signature. 218491010972 Signal peptide predicted for ECA2253 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.740 between residues 31 and 32; signal peptide 218491010973 hypothetical protein; Provisional; Region: PRK13659 218491010974 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491010975 1 probable transmembrane helix predicted for ECA2254 by TMHMM2.0 at aa 213-235 218491010976 Signal peptide predicted for ECA2255 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.807 between residues 21 and 22; signal peptide 218491010977 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 218491010978 Signal peptide predicted for ECA2256 by SignalP 2.0 HMM (Signal peptide probabilty 0.889) with cleavage site probability 0.361 between residues 39 and 40; signal peptide 218491010979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491010980 putative substrate translocation pore; other site 218491010981 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491010982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491010983 14 probable transmembrane helices predicted for ECA2256 by TMHMM2.0 at aa 17-39, 49-71, 83-104, 108-130, 143-165, 169-191, 204-223, 227-246, 266-288, 303-322, 329-351, 361-383, 404-426 and 456-478 218491010984 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0066 218491010985 putative dithiobiotin synthetase; Provisional; Region: PRK12374 218491010986 AAA domain; Region: AAA_26; pfam13500 218491010987 HMMPfam hit to PF01656, DE Cobyrinic acid a,c-diamide synthase, score 3e-39 218491010988 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 218491010989 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218491010990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218491010991 HMMPfam hit to PF00480, DE ROK family, score 8.3e-28 218491010992 Predicted helix-turn-helix motif with score 1041.000, SD 2.73 at aa 31-52, sequence ISRIELSKRAQLAPASITKIVR 218491010993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491010994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491010995 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 218491010996 dimerization interface [polypeptide binding]; other site 218491010997 substrate binding pocket [chemical binding]; other site 218491010998 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 3.4e-46 218491010999 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.1e-28 218491011000 PS00044 Bacterial regulatory proteins, lysR family signature. 218491011001 Predicted helix-turn-helix motif with score 1388.000, SD 3.91 at aa 18-39, sequence LHFGRAAERLRISQPPLSQQIQ 218491011002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491011003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491011004 putative substrate translocation pore; other site 218491011005 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011006 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00026 218491011007 12 probable transmembrane helices predicted for ECA2260 by TMHMM2.0 at aa 44-66, 81-102, 109-131, 135-157, 164-186, 196-218, 247-269, 273-295, 308-330, 335-357, 370-392 and 396-418 218491011008 PS00216 Sugar transport proteins signature 1. 218491011009 DNA replication terminus site-binding protein; Region: rep_term_tus; TIGR02648 218491011010 fumarate hydratase; Reviewed; Region: fumC; PRK00485 218491011011 Class II fumarases; Region: Fumarase_classII; cd01362 218491011012 active site 218491011013 tetramer interface [polypeptide binding]; other site 218491011014 HMMPfam hit to PF00206, DE Lyase, score 1.4e-219 218491011015 PS00163 Fumarate lyases signature. 218491011016 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 218491011017 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 218491011018 HMMPfam hit to PF01238, DE Phosphomannose isomerase type I, score 1.6e-152 218491011019 PS00965 Phosphomannose isomerase type I signature 1. 218491011020 PS00966 Phosphomannose isomerase type I signature 2. 218491011021 PS00196 Type-1 copper (blue) proteins signature. 218491011022 Signal peptide predicted for ECA2264 by SignalP 2.0 HMM (Signal peptide probabilty 0.942) with cleavage site probability 0.550 between residues 30 and 31; signal peptide 218491011023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 218491011024 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 218491011025 Signal peptide predicted for ECA2265 by SignalP 2.0 HMM (Signal peptide probabilty 0.676) with cleavage site probability 0.540 between residues 27 and 28; signal peptide 218491011026 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 218491011027 9 probable transmembrane helices predicted for ECA2265 by TMHMM2.0 at aa 13-30, 35-57, 70-92, 102-121, 128-150, 165-187, 200-219, 229-251 and 272-294 218491011028 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 218491011029 adenosine deaminase; Provisional; Region: PRK09358 218491011030 active site 218491011031 HMMPfam hit to PF00962, DE Adenosine/AMP deaminase, score 9.8e-105 218491011032 Signal peptide predicted for ECA2267 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.976 between residues 22 and 23; signal peptide 218491011033 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 218491011034 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 218491011035 Signal peptide predicted for ECA2268 by SignalP 2.0 HMM (Signal peptide probabilty 0.933) with cleavage site probability 0.479 between residues 28 and 29; signal peptide 218491011036 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 218491011037 9 probable transmembrane helices predicted for ECA2268 by TMHMM2.0 at aa 12-29, 34-56, 69-91, 101-123, 128-150, 165-184, 205-227, 232-254 and 275-297 218491011038 HMMPfam hit to PF01758, DE Sodium Bile acid symporter family, score 0.0096 218491011039 putative oxidoreductase; Provisional; Region: PRK11579 218491011040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491011041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 218491011042 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 5.8e-19 218491011043 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 1e-39 218491011044 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 218491011045 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491011046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491011047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491011048 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 2.8e-12 218491011049 PS00041 Bacterial regulatory proteins, araC family signature. 218491011050 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.1e-09 218491011051 Predicted helix-turn-helix motif with score 1772.000, SD 5.22 at aa 200-221, sequence LRIDEVARHVCLSPSRLAHLFR 218491011052 HMMPfam hit to PF02311, DE Arabinose operon regulatory protein, score 6.2e-143 218491011053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491011054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491011055 TM-ABC transporter signature motif; other site 218491011056 10 probable transmembrane helices predicted for ECA2271 by TMHMM2.0 at aa 21-43, 53-72, 79-98, 102-124, 131-150, 170-192, 222-241, 251-269, 276-298 and 303-317 218491011057 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011058 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 218491011059 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491011060 Walker A/P-loop; other site 218491011061 ATP binding site [chemical binding]; other site 218491011062 Q-loop/lid; other site 218491011063 ABC transporter signature motif; other site 218491011064 Walker B; other site 218491011065 D-loop; other site 218491011066 H-loop/switch region; other site 218491011067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491011068 HMMPfam hit to PF00005, DE ABC transporter, score 2.6e-29 218491011069 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491011070 PS00211 ABC transporters family signature. 218491011071 HMMPfam hit to PF00005, DE ABC transporter, score 1e-60 218491011072 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011073 Signal peptide predicted for ECA2273 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 23 and 24; signal peptide 218491011074 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 218491011075 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 218491011076 ligand binding site [chemical binding]; other site 218491011077 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 6.9e-92 218491011078 ribulokinase; Provisional; Region: PRK04123 218491011079 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 218491011080 N- and C-terminal domain interface [polypeptide binding]; other site 218491011081 active site 218491011082 MgATP binding site [chemical binding]; other site 218491011083 catalytic site [active] 218491011084 metal binding site [ion binding]; metal-binding site 218491011085 carbohydrate binding site [chemical binding]; other site 218491011086 homodimer interface [polypeptide binding]; other site 218491011087 HMMPfam hit to PF00370, DE FGGY family of carbohydrate kinases, N-terminal domain, score 0.00066 218491011088 HMMPfam hit to PF02782, DE FGGY family of carbohydrate kinases, C-terminal domain, score 1.4e-05 218491011089 L-arabinose isomerase; Provisional; Region: PRK02929 218491011090 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 218491011091 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 218491011092 trimer interface [polypeptide binding]; other site 218491011093 putative substrate binding site [chemical binding]; other site 218491011094 putative metal binding site [ion binding]; other site 218491011095 HMMPfam hit to PF02610, DE L-arabinose isomerase, score 0 218491011096 electron transport complex protein RsxA; Provisional; Region: PRK05151 218491011097 HMMPfam hit to PF02508, DE Rnf-Nqr subunit, membrane protein, score 2.4e-99 218491011098 6 probable transmembrane helices predicted for ECA2276 by TMHMM2.0 at aa 13-35, 55-77, 82-104, 119-141, 154-173 and 188-210 218491011099 Signal peptide predicted for ECA2277 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.751 between residues 23 and 24; signal peptide 218491011100 electron transport complex protein RnfB; Provisional; Region: PRK05113 218491011101 Putative Fe-S cluster; Region: FeS; cl17515 218491011102 4Fe-4S binding domain; Region: Fer4; pfam00037 218491011103 1 probable transmembrane helix predicted for ECA2277 by TMHMM2.0 at aa 4-26 218491011104 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 8.7e-07 218491011105 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491011106 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00017 218491011107 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491011108 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 218491011109 SLBB domain; Region: SLBB; pfam10531 218491011110 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491011111 HMMPfam hit to PF01512, DE Respiratory-chain NADH dehydrogenase 51 Kd subunit, score 2.8e-75 218491011112 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.0047 218491011113 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491011114 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.0028 218491011115 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491011116 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 218491011117 HMMPfam hit to PF03116, DE NQR2, RnfD, RnfE family, score 1e-150 218491011118 8 probable transmembrane helices predicted for ECA2279 by TMHMM2.0 at aa 20-42, 92-114, 121-143, 218-235, 242-264, 269-288, 301-318 and 323-342 218491011119 Signal peptide predicted for ECA2280 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.560 between residues 23 and 24; signal peptide 218491011120 electron transport complex protein RnfG; Validated; Region: PRK01908 218491011121 electron transport complex RsxE subunit; Provisional; Region: PRK12405 218491011122 Signal peptide predicted for ECA2281 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.362 between residues 38 and 39; signal peptide 218491011123 HMMPfam hit to PF02508, DE Rnf-Nqr subunit, membrane protein, score 3e-111 218491011124 5 probable transmembrane helices predicted for ECA2281 by TMHMM2.0 at aa 34-56, 69-86, 90-112, 124-146 and 184-206 218491011125 PS00284 Serpins signature. 218491011126 endonuclease III; Provisional; Region: PRK10702 218491011127 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218491011128 minor groove reading motif; other site 218491011129 helix-hairpin-helix signature motif; other site 218491011130 substrate binding pocket [chemical binding]; other site 218491011131 active site 218491011132 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 218491011133 HMMPfam hit to PF00730, DE HhH-GPD superfamily base excision DNA repair protein, score 1e-69 218491011134 PS01155 Endonuclease III family signature. 218491011135 PS00764 Endonuclease III iron-sulfur binding region signature. 218491011136 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 218491011137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491011138 putative substrate translocation pore; other site 218491011139 POT family; Region: PTR2; pfam00854 218491011140 14 probable transmembrane helices predicted for ECA2283 by TMHMM2.0 at aa 48-70, 85-107, 116-133, 138-155, 176-198, 203-225, 242-264, 274-296, 301-318, 349-366, 379-397, 412-434, 441-463 and 483-505 218491011141 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 218491011142 HMMPfam hit to PF00854, DE POT family, score 2.9e-93 218491011143 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 218491011144 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 218491011145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491011146 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 218491011147 substrate binding site [chemical binding]; other site 218491011148 putative dimerization interface [polypeptide binding]; other site 218491011149 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.5e-42 218491011150 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218491011151 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.1e-17 218491011152 PS00044 Bacterial regulatory proteins, lysR family signature. 218491011153 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 218491011154 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 218491011155 active site 218491011156 interdomain interaction site; other site 218491011157 putative metal-binding site [ion binding]; other site 218491011158 nucleotide binding site [chemical binding]; other site 218491011159 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218491011160 domain I; other site 218491011161 DNA binding groove [nucleotide binding] 218491011162 phosphate binding site [ion binding]; other site 218491011163 domain II; other site 218491011164 domain III; other site 218491011165 nucleotide binding site [chemical binding]; other site 218491011166 catalytic site [active] 218491011167 domain IV; other site 218491011168 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218491011169 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218491011170 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 218491011171 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 218491011172 HMMPfam hit to PF01396, DE Topoisomerase DNA binding C4 zinc finger, score 1.3e-10 218491011173 HMMPfam hit to PF01396, DE Topoisomerase DNA binding C4 zinc finger, score 6.7e-11 218491011174 HMMPfam hit to PF01131, DE DNA topoisomerase, score 7e-178 218491011175 PS00396 Prokaryotic DNA topoisomerase I active site. 218491011176 HMMPfam hit to PF01751, DE Toprim domain, score 7.3e-34 218491011177 hypothetical protein; Provisional; Region: PRK11037 218491011178 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 218491011179 putative inner membrane peptidase; Provisional; Region: PRK11778 218491011180 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 218491011181 tandem repeat interface [polypeptide binding]; other site 218491011182 oligomer interface [polypeptide binding]; other site 218491011183 active site residues [active] 218491011184 HMMPfam hit to PF01343, DE Peptidase family U7, score 4.1e-51 218491011185 2 probable transmembrane helices predicted for ECA2288 by TMHMM2.0 at aa 10-32 and 191-208 218491011186 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 218491011187 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 218491011188 NADP binding site [chemical binding]; other site 218491011189 homodimer interface [polypeptide binding]; other site 218491011190 active site 218491011191 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2.3e-61 218491011192 PS00061 Short-chain dehydrogenases/reductases family signature. 218491011193 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 218491011194 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 218491011195 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 218491011196 homodimer interface [polypeptide binding]; other site 218491011197 Walker A motif; other site 218491011198 ATP binding site [chemical binding]; other site 218491011199 hydroxycobalamin binding site [chemical binding]; other site 218491011200 Walker B motif; other site 218491011201 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02572, DE ATP:corrinoid adenosyltransferase BtuR/CobO/CobP, score 2.8e-104 218491011202 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 218491011203 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491011204 RNA binding surface [nucleotide binding]; other site 218491011205 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 218491011206 probable active site [active] 218491011207 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 1.8e-14 218491011208 PS01149 Rsu family of pseudouridine synthase signature. 218491011209 HMMPfam hit to PF01479, DE S4 domain, score 5.4e-06 218491011210 hypothetical protein; Provisional; Region: PRK11630 218491011211 HMMPfam hit to PF01300, DE yrdC domain, score 6.7e-63 218491011212 PS01147 SUA5/yciO/yrdC family signature. 218491011213 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 218491011214 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 218491011215 active site 218491011216 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 218491011217 HMMPfam hit to PF02811, DE PHP domain C-terminal region, score 2.4e-13 218491011218 HMMPfam hit to PF02231, DE PHP domain N-terminal region, score 9.7e-19 218491011219 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 218491011220 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 218491011221 Ligand binding site; other site 218491011222 DXD motif; other site 218491011223 10 probable transmembrane helices predicted for ECA2294 by TMHMM2.0 at aa 12-31, 41-63, 65-87, 91-113, 120-142, 442-464, 471-493, 503-525, 545-567 and 577-599 218491011224 HMMPfam hit to PF00535, DE Glycosyl transferase, score 4.7e-20 218491011225 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 218491011226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491011227 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 7.4 218491011228 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.86 218491011229 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491011230 anthranilate synthase component I; Provisional; Region: PRK13564 218491011231 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 218491011232 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 218491011233 HMMPfam hit to PF00425, DE chorismate binding enzyme, score 1.8e-162 218491011234 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 218491011235 Glutamine amidotransferase class-I; Region: GATase; pfam00117 218491011236 glutamine binding [chemical binding]; other site 218491011237 catalytic triad [active] 218491011238 HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 2.7e-67 218491011239 PS00442 Glutamine amidotransferases class-I active site. 218491011240 HMMPfam hit to PF02885, DE Glycosyl transferase family, helical bundle domain, score 5.1e-19 218491011241 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 218491011242 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218491011243 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 218491011244 HMMPfam hit to PF00591, DE Glycosyl transferase family, a/b domain, score 1.3e-136 218491011245 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011246 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 218491011247 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 218491011248 active site 218491011249 ribulose/triose binding site [chemical binding]; other site 218491011250 phosphate binding site [ion binding]; other site 218491011251 substrate (anthranilate) binding pocket [chemical binding]; other site 218491011252 product (indole) binding pocket [chemical binding]; other site 218491011253 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 218491011254 active site 218491011255 HMMPfam hit to PF00218, DE Indole-3-glycerol phosphate synthase, score 5.9e-142 218491011256 PS00614 Indole-3-glycerol phosphate synthase signature. 218491011257 HMMPfam hit to PF00697, DE N-(5'phosphoribosyl)anthranilate (PRA) isomerase, score 4.3e-74 218491011258 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011259 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 218491011260 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 218491011261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491011262 catalytic residue [active] 218491011263 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 4e-116 218491011264 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 218491011265 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011266 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 218491011267 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 218491011268 substrate binding site [chemical binding]; other site 218491011269 active site 218491011270 catalytic residues [active] 218491011271 heterodimer interface [polypeptide binding]; other site 218491011272 HMMPfam hit to PF00290, DE Tryptophan synthase alpha chain, score 5.4e-146 218491011273 PS00167 Tryptophan synthase alpha chain signature. 218491011274 Signal peptide predicted for ECA2302 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 20 and 21; signal peptide 218491011275 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 218491011276 Signal peptide predicted for ECA2303 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 20 and 21; signal peptide 218491011277 outer membrane protein W; Provisional; Region: PRK10959 218491011278 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03922, DE OmpW family, score 1.2e-99 218491011279 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00695 Enterobacterial virulence outer membrane protein signature 2. 218491011280 1 probable transmembrane helix predicted for ECA2304 by TMHMM2.0 at aa 13-35 218491011281 Signal peptide predicted for ECA2305 by SignalP 2.0 HMM (Signal peptide probabilty 0.697) with cleavage site probability 0.290 between residues 40 and 41; signal peptide 218491011282 hypothetical protein; Provisional; Region: PRK02868 218491011283 6 probable transmembrane helices predicted for ECA2305 by TMHMM2.0 at aa 20-42, 88-110, 122-144, 148-170, 190-212 and 222-244 218491011284 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491011285 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491011286 active site 218491011287 DNA binding site [nucleotide binding] 218491011288 Int/Topo IB signature motif; other site 218491011289 HMMPfam hit to PF00589, DE Phage integrase family, score 2.7e-08 218491011290 protein kinase; Region: PHA00451 218491011291 BRO family, N-terminal domain; Region: Bro-N; smart01040 218491011292 HMMPfam hit to PF02498, DE BRO family, N-terminal domain, score 0.0027 218491011293 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 218491011294 PS00430 TonB-dependent receptor proteins signature 1. 218491011295 intracellular septation protein A; Reviewed; Region: PRK00259 218491011296 5 probable transmembrane helices predicted for ECA2313 by TMHMM2.0 at aa 22-44, 51-68, 78-95, 119-141 and 151-170 218491011297 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 218491011298 HMMPfam hit to PF01662, , score 1.1e-61 218491011299 Signal peptide predicted for ECA2315 by SignalP 2.0 HMM (Signal peptide probabilty 0.667) with cleavage site probability 0.333 between residues 28 and 29; signal peptide 218491011300 transport protein TonB; Provisional; Region: PRK10819 218491011301 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 218491011302 HMMPfam hit to PF03544, DE Gram-negative bacterial tonB protein, score 2.7e-15 218491011303 YciI-like protein; Reviewed; Region: PRK11370 218491011304 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03795, DE YCII-related domain, score 2.3e-41 218491011305 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 218491011306 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218491011307 dimer interface [polypeptide binding]; other site 218491011308 ligand binding site [chemical binding]; other site 218491011309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491011310 dimer interface [polypeptide binding]; other site 218491011311 putative CheW interface [polypeptide binding]; other site 218491011312 3 probable transmembrane helices predicted for ECA2317 by TMHMM2.0 at aa 26-48, 63-85 and 250-269 218491011313 HMMPfam hit to PF02203, DE Tar ligand binding domain homologue, score 7.5e-10 218491011314 HMMPfam hit to PF00672, DE HAMP domain, score 2.1e-06 218491011315 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 4.3e-29 218491011316 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 218491011317 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 218491011318 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 218491011319 putative active site [active] 218491011320 catalytic site [active] 218491011321 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 218491011322 putative active site [active] 218491011323 catalytic site [active] 218491011324 2 probable transmembrane helices predicted for ECA2318 by TMHMM2.0 at aa 10-29 and 36-58 218491011325 HMMPfam hit to PF00614, DE Phospholipase D. Active site motif, score 2e-06 218491011326 HMMPfam hit to PF00614, DE Phospholipase D. Active site motif, score 4.6e-06 218491011327 dsDNA-mimic protein; Reviewed; Region: PRK05094 218491011328 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 218491011329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491011330 Walker A/P-loop; other site 218491011331 ATP binding site [chemical binding]; other site 218491011332 Q-loop/lid; other site 218491011333 ABC transporter signature motif; other site 218491011334 Walker B; other site 218491011335 D-loop; other site 218491011336 H-loop/switch region; other site 218491011337 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218491011338 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-62 218491011339 PS00211 ABC transporters family signature. 218491011340 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011341 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 218491011342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491011343 Walker A/P-loop; other site 218491011344 ATP binding site [chemical binding]; other site 218491011345 Q-loop/lid; other site 218491011346 ABC transporter signature motif; other site 218491011347 Walker B; other site 218491011348 D-loop; other site 218491011349 H-loop/switch region; other site 218491011350 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218491011351 HMMPfam hit to PF00005, DE ABC transporter, score 1.8e-58 218491011352 PS00211 ABC transporters family signature. 218491011353 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011354 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 218491011355 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218491011356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491011357 dimer interface [polypeptide binding]; other site 218491011358 conserved gate region; other site 218491011359 ABC-ATPase subunit interface; other site 218491011360 6 probable transmembrane helices predicted for ECA2322 by TMHMM2.0 at aa 40-62, 108-130, 143-160, 164-183, 214-236 and 268-290 218491011361 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.2e-05 218491011362 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491011363 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 218491011364 Signal peptide predicted for ECA2323 by SignalP 2.0 HMM (Signal peptide probabilty 0.831) with cleavage site probability 0.421 between residues 32 and 33; signal peptide 218491011365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491011366 dimer interface [polypeptide binding]; other site 218491011367 conserved gate region; other site 218491011368 putative PBP binding loops; other site 218491011369 ABC-ATPase subunit interface; other site 218491011370 6 probable transmembrane helices predicted for ECA2323 by TMHMM2.0 at aa 13-30, 100-122, 134-156, 166-188, 228-250 and 278-300 218491011371 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.4e-06 218491011372 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491011373 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 218491011374 Signal peptide predicted for ECA2324 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 28 and 29; signal peptide 218491011375 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218491011376 peptide binding site [polypeptide binding]; other site 218491011377 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 2.1e-220 218491011378 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 218491011379 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 218491011380 Signal peptide predicted for ECA2325 by SignalP 2.0 HMM (Signal peptide probabilty 0.936) with cleavage site probability 0.913 between residues 15 and 16; signal peptide 218491011381 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218491011382 peptide binding site [polypeptide binding]; other site 218491011383 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 4.2e-216 218491011384 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 218491011385 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 218491011386 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 218491011387 putative catalytic cysteine [active] 218491011388 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 218491011389 putative active site [active] 218491011390 metal binding site [ion binding]; metal-binding site 218491011391 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 3.2e-05 218491011392 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 1.6e-222 218491011393 PS00913 Iron-containing alcohol dehydrogenases signature 1. 218491011394 PS00060 Iron-containing alcohol dehydrogenases signature 2. 218491011395 thymidine kinase; Provisional; Region: PRK04296 218491011396 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 218491011397 ATP binding site [chemical binding]; other site 218491011398 Walker A motif; other site 218491011399 Walker B motif; other site 218491011400 HMMPfam hit to PF00265, DE Thymidine kinase, score 1.6e-91 218491011401 PS00603 Thymidine kinase cellular-type signature. 218491011402 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 218491011403 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 218491011404 HMMPfam hit to PF00816, DE H-NS histone family, score 2.5e-90 218491011405 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011406 Signal peptide predicted for ECA2329 by SignalP 2.0 HMM (Signal peptide probabilty 0.726) with cleavage site probability 0.678 between residues 27 and 28; signal peptide 218491011407 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 218491011408 active site 218491011409 tetramer interface; other site 218491011410 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 2.5e-09 218491011411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491011412 active site 218491011413 response regulator of RpoS; Provisional; Region: PRK10693 218491011414 phosphorylation site [posttranslational modification] 218491011415 intermolecular recognition site; other site 218491011416 dimerization interface [polypeptide binding]; other site 218491011417 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 8.3e-25 218491011418 hypothetical protein; Provisional; Region: PRK10279 218491011419 Signal peptide predicted for ECA2331 by SignalP 2.0 HMM (Signal peptide probabilty 0.737) with cleavage site probability 0.485 between residues 19 and 20; signal peptide 218491011420 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 218491011421 active site 218491011422 nucleophile elbow; other site 218491011423 HMMPfam hit to PF01734, DE Patatin-like phospholipase, score 2.4e-56 218491011424 hypothetical protein; Provisional; Region: PRK04233 218491011425 HMMPfam hit to PF02810, DE SEC-C motif, score 0.017 218491011426 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02810, DE SEC-C motif, score 6.9e-05 218491011427 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 218491011428 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 218491011429 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 218491011430 putative active site [active] 218491011431 putative substrate binding site [chemical binding]; other site 218491011432 putative cosubstrate binding site; other site 218491011433 catalytic site [active] 218491011434 HMMPfam hit to PF01842, DE ACT domain, score 8.7e-06 218491011435 HMMPfam hit to PF00551, DE Formyl transferase, score 1.3e-71 218491011436 Predicted membrane protein [Function unknown]; Region: COG2860 218491011437 UPF0126 domain; Region: UPF0126; pfam03458 218491011438 UPF0126 domain; Region: UPF0126; pfam03458 218491011439 HMMPfam hit to PF03458, DE UPF0126 domain, score 6.3e-30 218491011440 5 probable transmembrane helices predicted for ECA2334 by TMHMM2.0 at aa 4-21, 28-50, 63-80, 87-109 and 114-136 218491011441 HMMPfam hit to PF03458, DE UPF0126 domain, score 4.2e-24 218491011442 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 218491011443 putative catalytic site [active] 218491011444 putative phosphate binding site [ion binding]; other site 218491011445 active site 218491011446 metal binding site A [ion binding]; metal-binding site 218491011447 DNA binding site [nucleotide binding] 218491011448 putative AP binding site [nucleotide binding]; other site 218491011449 putative metal binding site B [ion binding]; other site 218491011450 HMMPfam hit to PF03372, DE Endonuclease/Exonuclease/phosphatase family, score 8.1e-53 218491011451 PS00726 AP endonucleases family 1 signature 1. 218491011452 PS00728 AP endonucleases family 1 signature 3. 218491011453 Signal peptide predicted for ECA2336 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.652 between residues 22 and 23; signal peptide 218491011454 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 218491011455 DNA topoisomerase III; Provisional; Region: PRK07726 218491011456 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 218491011457 active site 218491011458 putative interdomain interaction site [polypeptide binding]; other site 218491011459 putative metal-binding site [ion binding]; other site 218491011460 putative nucleotide binding site [chemical binding]; other site 218491011461 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218491011462 domain I; other site 218491011463 DNA binding groove [nucleotide binding] 218491011464 phosphate binding site [ion binding]; other site 218491011465 domain II; other site 218491011466 domain III; other site 218491011467 nucleotide binding site [chemical binding]; other site 218491011468 catalytic site [active] 218491011469 domain IV; other site 218491011470 HMMPfam hit to PF01131, DE DNA topoisomerase, score 6.8e-177 218491011471 PS00396 Prokaryotic DNA topoisomerase I active site. 218491011472 Predicted helix-turn-helix motif with score 1006.000, SD 2.61 at aa 296-317, sequence TLQIEAAKRFGLSAQQVLDVCQ 218491011473 HMMPfam hit to PF01751, DE Toprim domain, score 2.6e-31 218491011474 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 218491011475 putative FMN binding site [chemical binding]; other site 218491011476 HMMPfam hit to PF00881, DE Nitroreductase family, score 1.4e-29 218491011477 protease 4; Provisional; Region: PRK10949 218491011478 Signal peptide predicted for ECA2339 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.568 between residues 45 and 46; signal peptide 218491011479 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 218491011480 tandem repeat interface [polypeptide binding]; other site 218491011481 oligomer interface [polypeptide binding]; other site 218491011482 active site residues [active] 218491011483 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 218491011484 tandem repeat interface [polypeptide binding]; other site 218491011485 oligomer interface [polypeptide binding]; other site 218491011486 active site residues [active] 218491011487 1 probable transmembrane helix predicted for ECA2339 by TMHMM2.0 at aa 21-43 218491011488 HMMPfam hit to PF01343, DE Peptidase family U7, score 1.9e-45 218491011489 HMMPfam hit to PF01343, DE Peptidase family U7, score 1.7e-63 218491011490 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 218491011491 active site 218491011492 homodimer interface [polypeptide binding]; other site 218491011493 PS00144 Asparaginase / glutaminase active site signature 1. 218491011494 HMMPfam hit to PF00710, DE Asparaginase, score 6.4e-114 218491011495 PS00917 Asparaginase / glutaminase active site signature 2. 218491011496 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 218491011497 Isochorismatase family; Region: Isochorismatase; pfam00857 218491011498 catalytic triad [active] 218491011499 metal binding site [ion binding]; metal-binding site 218491011500 conserved cis-peptide bond; other site 218491011501 HMMPfam hit to PF00857, DE Isochorismatase family, score 7.9e-40 218491011502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 218491011503 methionine sulfoxide reductase B; Provisional; Region: PRK00222 218491011504 SelR domain; Region: SelR; pfam01641 218491011505 HMMPfam hit to PF01641, DE SelR domain, score 8.5e-65 218491011506 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 218491011507 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 218491011508 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218491011509 HMMPfam hit to PF00044, DE Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 6.3e-99 218491011510 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 218491011511 HMMPfam hit to PF02800, DE Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 2.1e-124 218491011512 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 218491011513 active site 218491011514 phosphate binding residues; other site 218491011515 catalytic residues [active] 218491011516 HMMPfam hit to PF01263, DE Aldose 1-epimerase, score 2e-37 218491011517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491011518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491011519 active site 218491011520 catalytic tetrad [active] 218491011521 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 3.2e-66 218491011522 Signal peptide predicted for ECA2347 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25; signal peptide 218491011523 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 218491011524 PrkA family serine protein kinase; Provisional; Region: PRK15455 218491011525 AAA ATPase domain; Region: AAA_16; pfam13191 218491011526 Walker A motif; other site 218491011527 ATP binding site [chemical binding]; other site 218491011528 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 218491011529 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011530 hypothetical protein; Provisional; Region: PRK05325 218491011531 Signal peptide predicted for ECA2350 by SignalP 2.0 HMM (Signal peptide probabilty 0.893) with cleavage site probability 0.786 between residues 32 and 33; signal peptide 218491011532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491011533 putative substrate translocation pore; other site 218491011534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491011535 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 1.2e-05 218491011536 12 probable transmembrane helices predicted for ECA2350 by TMHMM2.0 at aa 7-29, 39-61, 73-95, 99-116, 129-151, 156-178, 205-227, 242-260, 273-295, 305-327, 340-362 and 366-385 218491011537 PS00216 Sugar transport proteins signature 1. 218491011538 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 218491011539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491011540 hydroxyglutarate oxidase; Provisional; Region: PRK11728 218491011541 HMMPfam hit to PF01266, DE FAD dependent oxidoreductase, score 0.002 218491011542 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 218491011543 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 218491011544 active site 218491011545 ADP/pyrophosphate binding site [chemical binding]; other site 218491011546 dimerization interface [polypeptide binding]; other site 218491011547 allosteric effector site; other site 218491011548 fructose-1,6-bisphosphate binding site; other site 218491011549 HMMPfam hit to PF00365, DE Phosphofructokinase, score 4e-15 218491011550 Signal peptide predicted for ECA2353 by SignalP 2.0 HMM (Signal peptide probabilty 0.952) with cleavage site probability 0.661 between residues 17 and 18; signal peptide 218491011551 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218491011552 active site 218491011553 P-loop; other site 218491011554 phosphorylation site [posttranslational modification] 218491011555 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 218491011556 12 probable transmembrane helices predicted for ECA2354 by TMHMM2.0 at aa 12-30, 45-67, 94-116, 120-142, 149-171, 181-202, 223-245, 265-287, 308-330, 340-362, 375-397 and 417-439 218491011557 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218491011558 active site 218491011559 phosphorylation site [posttranslational modification] 218491011560 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00359, DE Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 5.5e-23 218491011561 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011562 AAA domain; Region: AAA_17; pfam13207 218491011563 AAA domain; Region: AAA_18; pfam13238 218491011564 Class I aldolases; Region: Aldolase_Class_I; cl17187 218491011565 catalytic residue [active] 218491011566 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011567 PS01047 Heavy-metal-associated domain. 218491011568 SpoVR family protein; Provisional; Region: PRK11767 218491011569 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 218491011570 fatty acid metabolism regulator; Provisional; Region: PRK04984 218491011571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491011572 DNA-binding site [nucleotide binding]; DNA binding site 218491011573 FadR C-terminal domain; Region: FadR_C; pfam07840 218491011574 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 3.4e-25 218491011575 PS00043 Bacterial regulatory proteins, gntR family signature. 218491011576 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 218491011577 11 probable transmembrane helices predicted for ECA2361 by TMHMM2.0 at aa 21-40, 44-66, 97-119, 139-161, 202-224, 242-264, 301-320, 324-341, 354-376, 396-418 and 480-502 218491011578 disulfide bond formation protein B; Provisional; Region: PRK01749 218491011579 Signal peptide predicted for ECA2362 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.975 between residues 24 and 25; signal peptide 218491011580 HMMPfam hit to PF02600, DE Disulfide bond formation protein DsbB, score 2.6e-64 218491011581 3 probable transmembrane helices predicted for ECA2362 by TMHMM2.0 at aa 13-35, 50-69 and 145-167 218491011582 Glycogen synthesis protein; Region: GlgS; cl11663 218491011583 Signal peptide predicted for ECA2364 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.709 between residues 18 and 19; signal peptide 218491011584 cell division protein MukB; Provisional; Region: mukB; PRK04863 218491011585 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011586 hypothetical protein; Provisional; Region: PRK05170 218491011587 hypothetical protein; Provisional; Region: PRK10691 218491011588 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 218491011589 HMMPfam hit to PF01557, DE Fumarylacetoacetate (FAA) hydrolase family, score 4.4e-78 218491011590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 218491011591 septum formation inhibitor; Reviewed; Region: minC; PRK03511 218491011592 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 218491011593 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 218491011594 HMMPfam hit to PF03775, DE Septum formation inhibitor MinC, C-terminal domain, score 2.3e-66 218491011595 cell division inhibitor MinD; Provisional; Region: PRK10818 218491011596 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 218491011597 Switch I; other site 218491011598 Switch II; other site 218491011599 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011600 HMMPfam hit to PF00991, DE ParA family ATPase, score 6.6e-05 218491011601 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 218491011602 HMMPfam hit to PF03776, DE Septum formation topological specificity factor MinE, score 1.8e-49 218491011603 ribonuclease D; Provisional; Region: PRK10829 218491011604 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 218491011605 catalytic site [active] 218491011606 putative active site [active] 218491011607 putative substrate binding site [chemical binding]; other site 218491011608 HRDC domain; Region: HRDC; pfam00570 218491011609 HMMPfam hit to PF00570, DE HRDC domain, score 8.5e-15 218491011610 HMMPfam hit to PF01612, DE 3'-5' exonuclease, score 3.3e-48 218491011611 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 218491011612 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 218491011613 acyl-activating enzyme (AAE) consensus motif; other site 218491011614 putative AMP binding site [chemical binding]; other site 218491011615 putative active site [active] 218491011616 putative CoA binding site [chemical binding]; other site 218491011617 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 5.7e-125 218491011618 PS00455 AMP-binding domain signature. 218491011619 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491011620 Signal peptide predicted for ECA2373 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.396 between residues 27 and 28; signal peptide 218491011621 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 218491011622 HMMPfam hit to PF03843, DE Outer membrane lipoprotein Slp family, score 5.7e-69 218491011623 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011624 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 218491011625 Glycoprotease family; Region: Peptidase_M22; pfam00814 218491011626 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 218491011627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 218491011628 DEAD_2; Region: DEAD_2; pfam06733 218491011629 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 218491011630 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011631 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 218491011632 homotrimer interaction site [polypeptide binding]; other site 218491011633 putative active site [active] 218491011634 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01042, DE Endoribonuclease L-PSP, score 9.9e-35 218491011635 PS01094 Uncharacterized protein family UPF0076 signature. 218491011636 hypothetical protein; Provisional; Region: PRK05114 218491011637 HMMPfam hit to PF03701, DE Uncharacterised protein family (UPF0181), score 1e-25 218491011638 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 218491011639 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 218491011640 chorismate binding enzyme; Region: Chorismate_bind; cl10555 218491011641 HMMPfam hit to PF00425, DE chorismate binding enzyme, score 2.5e-124 218491011642 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 218491011643 putative active site [active] 218491011644 putative CoA binding site [chemical binding]; other site 218491011645 nudix motif; other site 218491011646 metal binding site [ion binding]; metal-binding site 218491011647 HMMPfam hit to PF00293, DE NUDIX domain, score 1.5e-14 218491011648 PS01293 Uncharacterized protein family UPF0035 signature. 218491011649 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 218491011650 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218491011651 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 218491011652 HMMPfam hit to PF03315, DE Serine dehydratase beta chain, score 2e-96 218491011653 HMMPfam hit to PF03313, DE Serine dehydratase alpha chain, score 1e-201 218491011654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491011655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491011656 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491011657 putative effector binding pocket; other site 218491011658 dimerization interface [polypeptide binding]; other site 218491011659 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.2e-41 218491011660 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 8e-16 218491011661 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 218491011662 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 218491011663 HMMPfam hit to PF03807, DE NADP oxidoreductase coenzyme F420-dependent, score 4.4e-13 218491011664 Signal peptide predicted for ECA2383 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 24 and 25 218491011665 Isochorismatase family; Region: Isochorismatase; pfam00857 218491011666 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 218491011667 catalytic triad [active] 218491011668 dimer interface [polypeptide binding]; other site 218491011669 conserved cis-peptide bond; other site 218491011670 HMMPfam hit to PF00857, DE Isochorismatase family, score 2.1e-05 218491011671 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 218491011672 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218491011673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218491011674 Transporter associated domain; Region: CorC_HlyC; smart01091 218491011675 HMMPfam hit to PF03471, DE Transporter associated domain, score 6.9e-13 218491011676 HMMPfam hit to PF00571, DE CBS domain, score 0.0061 218491011677 HMMPfam hit to PF00571, DE CBS domain, score 2.9e-06 218491011678 7 probable transmembrane helices predicted for ECA2384 by TMHMM2.0 at aa 10-32, 45-67, 82-100, 120-142, 152-169, 182-204 and 209-228 218491011679 HMMPfam hit to PF03741, DE Integral membrane protein TerC family, score 4.3e-79 218491011680 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 218491011681 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218491011682 active pocket/dimerization site; other site 218491011683 active site 218491011684 phosphorylation site [posttranslational modification] 218491011685 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218491011686 active site 218491011687 phosphorylation site [posttranslational modification] 218491011688 HMMPfam hit to PF03610, DE PTS system fructose IIA component, score 4.1e-44 218491011689 HMMPfam hit to PF03830, DE PTS system sorbose subfamily IIB component, score 1.8e-87 218491011690 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 218491011691 HMMPfam hit to PF03609, DE PTS system sorbose-specific iic component, score 2.2e-143 218491011692 6 probable transmembrane helices predicted for ECA2386 by TMHMM2.0 at aa 21-39, 64-86, 93-115, 166-188, 195-217 and 232-254 218491011693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011694 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 218491011695 HMMPfam hit to PF03613, DE PTS system mannose/fructose/sorbose family IID component, score 3.6e-175 218491011696 5 probable transmembrane helices predicted for ECA2387 by TMHMM2.0 at aa 99-121, 136-158, 179-201, 230-252 and 259-278 218491011697 Signal peptide predicted for ECA2388 by SignalP 2.0 HMM (Signal peptide probabilty 0.913) with cleavage site probability 0.706 between residues 17 and 18; signal peptide 218491011698 hypothetical protein; Provisional; Region: PRK02913 218491011699 3 probable transmembrane helices predicted for ECA2388 by TMHMM2.0 at aa 4-26, 47-64 and 68-87 218491011700 hypothetical protein; Provisional; Region: PRK11469 218491011701 Signal peptide predicted for ECA2389 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.979 between residues 19 and 20; signal peptide 218491011702 Domain of unknown function DUF; Region: DUF204; pfam02659 218491011703 Domain of unknown function DUF; Region: DUF204; pfam02659 218491011704 6 probable transmembrane helices predicted for ECA2389 by TMHMM2.0 at aa 4-26, 38-57, 62-84, 105-127, 131-153 and 166-184 218491011705 HMMPfam hit to PF02659, DE Domain of unknown function DUF, score 1.5e-30 218491011706 HMMPfam hit to PF02659, DE Domain of unknown function DUF, score 1.2e-29 218491011707 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 218491011708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491011709 S-adenosylmethionine binding site [chemical binding]; other site 218491011710 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218491011711 DNA-binding site [nucleotide binding]; DNA binding site 218491011712 RNA-binding motif; other site 218491011713 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00313, DE 'Cold-shock' DNA-binding domain, score 1.9e-42 218491011714 PS00352 'Cold-shock' DNA-binding domain signature. 218491011715 Signal peptide predicted for ECA2392 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 31 and 32; signal peptide 218491011716 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 218491011717 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 218491011718 metal binding site [ion binding]; metal-binding site 218491011719 HMMPfam hit to PF01297, DE Periplasmic solute binding protein family, score 7.4e-138 218491011720 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 218491011721 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218491011722 HMMPfam hit to PF00005, DE ABC transporter, score 4.9e-46 218491011723 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011724 PS00211 ABC transporters family signature. 218491011725 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218491011726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491011727 ABC-ATPase subunit interface; other site 218491011728 dimer interface [polypeptide binding]; other site 218491011729 putative PBP binding regions; other site 218491011730 HMMPfam hit to PF00950, DE ABC 3 transport family, score 5.5e-129 218491011731 8 probable transmembrane helices predicted for ECA2394 by TMHMM2.0 at aa 13-35, 50-72, 93-115, 135-157, 169-191, 195-214, 221-243 and 247-266 218491011732 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218491011733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491011734 ABC-ATPase subunit interface; other site 218491011735 dimer interface [polypeptide binding]; other site 218491011736 putative PBP binding regions; other site 218491011737 HMMPfam hit to PF00950, DE ABC 3 transport family, score 2.1e-139 218491011738 8 probable transmembrane helices predicted for ECA2395 by TMHMM2.0 at aa 20-42, 57-79, 96-115, 135-153, 170-192, 197-216, 223-245 and 250-267 218491011739 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011740 Phosphotransferase enzyme family; Region: APH; pfam01636 218491011741 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 218491011742 active site 218491011743 ATP binding site [chemical binding]; other site 218491011744 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 218491011745 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03881, DE Fructosamine kinase, score 2.9e-178 218491011746 Signal peptide predicted for ECA2397 by SignalP 2.0 HMM (Signal peptide probabilty 0.802) with cleavage site probability 0.587 between residues 38 and 39; signal peptide 218491011747 YniB-like protein; Region: YniB; pfam14002 218491011748 4 probable transmembrane helices predicted for ECA2397 by TMHMM2.0 at aa 15-37, 50-72, 87-109 and 153-175 218491011749 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 218491011750 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491011751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491011752 motif II; other site 218491011753 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 8.8e-31 218491011754 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 218491011755 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 218491011756 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 218491011757 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 218491011758 NADP binding site [chemical binding]; other site 218491011759 homodimer interface [polypeptide binding]; other site 218491011760 active site 218491011761 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.1e-89 218491011762 PS00061 Short-chain dehydrogenases/reductases family signature. 218491011763 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 218491011764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491011765 dimer interface [polypeptide binding]; other site 218491011766 conserved gate region; other site 218491011767 putative PBP binding loops; other site 218491011768 ABC-ATPase subunit interface; other site 218491011769 7 probable transmembrane helices predicted for ECA2403 by TMHMM2.0 at aa 7-29, 69-91, 104-126, 153-175, 196-215, 225-247 and 256-278 218491011770 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 6.2e-20 218491011771 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491011772 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218491011773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491011774 dimer interface [polypeptide binding]; other site 218491011775 conserved gate region; other site 218491011776 putative PBP binding loops; other site 218491011777 ABC-ATPase subunit interface; other site 218491011778 6 probable transmembrane helices predicted for ECA2404 by TMHMM2.0 at aa 30-52, 100-122, 129-151, 166-185, 206-228 and 263-285 218491011779 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.1e-11 218491011780 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491011781 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 218491011782 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218491011783 Walker A/P-loop; other site 218491011784 ATP binding site [chemical binding]; other site 218491011785 Q-loop/lid; other site 218491011786 ABC transporter signature motif; other site 218491011787 Walker B; other site 218491011788 D-loop; other site 218491011789 H-loop/switch region; other site 218491011790 TOBE domain; Region: TOBE; pfam03459 218491011791 HMMPfam hit to PF00005, DE ABC transporter, score 4.5e-51 218491011792 PS00211 ABC transporters family signature. 218491011793 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218491011794 Signal peptide predicted for ECA2406 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 23 and 24; signal peptide 218491011795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218491011796 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 5.3e-32 218491011797 Signal peptide predicted for ECA2407 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21; signal peptide 218491011798 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 218491011799 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 218491011800 Signal peptide predicted for ECA2408 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.900 between residues 21 and 22; signal peptide 218491011801 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218491011802 inner membrane protein; Provisional; Region: PRK11648 218491011803 Signal peptide predicted for ECA2410 by SignalP 2.0 HMM (Signal peptide probabilty 0.884) with cleavage site probability 0.594 between residues 24 and 25; signal peptide 218491011804 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 218491011805 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218491011806 9 probable transmembrane helices predicted for ECA2410 by TMHMM2.0 at aa 5-22, 34-52, 72-94, 106-128, 187-206, 261-283, 341-363, 370-392 and 396-418 218491011807 HMMPfam hit to PF00375, DE Sodium:dicarboxylate symporter family, score 4.8e-107 218491011808 Signal peptide predicted for ECA2411 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.401 between residues 25 and 26; signal peptide 218491011809 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 218491011810 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491011811 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 218491011812 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 218491011813 homodimer interface [polypeptide binding]; other site 218491011814 NAD binding pocket [chemical binding]; other site 218491011815 ATP binding pocket [chemical binding]; other site 218491011816 Mg binding site [ion binding]; other site 218491011817 active-site loop [active] 218491011818 HMMPfam hit to PF02540, DE NAD synthase, score 5.5e-69 218491011819 aromatic amino acid exporter; Provisional; Region: PRK11689 218491011820 10 probable transmembrane helices predicted for ECA2413 by TMHMM2.0 at aa 13-32, 37-59, 68-90, 100-118, 125-142, 157-178, 190-209, 224-242, 249-271 and 275-294 218491011821 PS00061 Short-chain dehydrogenases/reductases family signature. 218491011822 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 7e-06 218491011823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218491011824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491011825 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 218491011826 Walker A/P-loop; other site 218491011827 ATP binding site [chemical binding]; other site 218491011828 Q-loop/lid; other site 218491011829 ABC transporter signature motif; other site 218491011830 Walker B; other site 218491011831 D-loop; other site 218491011832 H-loop/switch region; other site 218491011833 4 probable transmembrane helices predicted for ECA2414 by TMHMM2.0 at aa 15-37, 50-72, 137-171 and 242-264 218491011834 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 9.9e-53 218491011835 HMMPfam hit to PF00005, DE ABC transporter, score 3.9e-63 218491011836 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011837 PS00211 ABC transporters family signature. 218491011838 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 218491011839 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218491011840 IHF dimer interface [polypeptide binding]; other site 218491011841 IHF - DNA interface [nucleotide binding]; other site 218491011842 HMMPfam hit to PF00216, DE Bacterial DNA-binding protein, score 1.2e-45 218491011843 PS00045 Bacterial histone-like DNA-binding proteins signature. 218491011844 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 218491011845 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 218491011846 putative tRNA-binding site [nucleotide binding]; other site 218491011847 B3/4 domain; Region: B3_4; pfam03483 218491011848 tRNA synthetase B5 domain; Region: B5; smart00874 218491011849 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 218491011850 dimer interface [polypeptide binding]; other site 218491011851 motif 1; other site 218491011852 motif 3; other site 218491011853 motif 2; other site 218491011854 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 218491011855 HMMPfam hit to PF03147, DE Ferredoxin-fold anticodon binding domain, score 1.1e-46 218491011856 HMMPfam hit to PF03484, DE tRNA synthetase B5 domain, score 1.3e-30 218491011857 HMMPfam hit to PF03483, DE B3/4 domain, score 4.6e-82 218491011858 HMMPfam hit to PF01588, DE tRNA binding domain, score 5.2e-42 218491011859 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 218491011860 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 218491011861 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 218491011862 dimer interface [polypeptide binding]; other site 218491011863 motif 1; other site 218491011864 active site 218491011865 motif 2; other site 218491011866 motif 3; other site 218491011867 HMMPfam hit to PF01409, DE tRNA synthetases class II core domain (F), score 1.2e-139 218491011868 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491011869 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491011870 HMMPfam hit to PF02912, DE Aminoacyl tRNA synthetase class II, N-terminal domain, score 8.4e-36 218491011871 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 218491011872 23S rRNA binding site [nucleotide binding]; other site 218491011873 L21 binding site [polypeptide binding]; other site 218491011874 L13 binding site [polypeptide binding]; other site 218491011875 HMMPfam hit to PF00453, DE Ribosomal protein L20, score 2.9e-68 218491011876 PS00937 Ribosomal protein L20 signature. 218491011877 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 218491011878 HMMPfam hit to PF01632, DE Ribosomal protein L35, score 3.8e-33 218491011879 PS00936 Ribosomal protein L35 signature. 218491011880 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 218491011881 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 218491011882 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 218491011883 HMMPfam hit to PF00707, DE Translation initiation factor IF-3, C-terminal domain, score 1.6e-47 218491011884 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 218491011885 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 218491011886 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 218491011887 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 218491011888 active site 218491011889 dimer interface [polypeptide binding]; other site 218491011890 motif 1; other site 218491011891 motif 2; other site 218491011892 motif 3; other site 218491011893 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 218491011894 anticodon binding site; other site 218491011895 HMMPfam hit to PF03129, DE Anticodon binding domain, score 3e-37 218491011896 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491011897 HMMPfam hit to PF00587, DE tRNA synthetase class II core domain (G, H, P, S and T), score 5.8e-57 218491011898 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491011899 HMMPfam hit to PF02824, DE TGS domain, score 1.1e-09 218491011900 aromatic amino acid transporter; Provisional; Region: PRK10238 218491011901 HMMPfam hit to PF00324, DE Amino acid permease, score 3.5e-198 218491011902 12 probable transmembrane helices predicted for ECA2423 by TMHMM2.0 at aa 21-40, 44-61, 95-117, 127-146, 153-175, 198-220, 240-262, 282-304, 331-353, 357-379, 399-421 and 425-443 218491011903 PS00024 Hemopexin domain signature. 218491011904 PS00218 Amino acid permeases signature. 218491011905 Signal peptide predicted for ECA2424 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.705 between residues 30 and 31; signal peptide 218491011906 YebO-like protein; Region: YebO; pfam13974 218491011907 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 218491011908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491011909 dimerization interface [polypeptide binding]; other site 218491011910 putative Zn2+ binding site [ion binding]; other site 218491011911 putative DNA binding site [nucleotide binding]; other site 218491011912 Bacterial transcriptional regulator; Region: IclR; pfam01614 218491011913 HMMPfam hit to PF01614, DE Bacterial transcriptional regulator, score 6.2e-86 218491011914 PS01051 Bacterial regulatory proteins, iclR family signature. 218491011915 Predicted helix-turn-helix motif with score 1951.000, SD 5.83 at aa 32-53, sequence IGITELSQRVMMSKSTVYRFLQ 218491011916 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 218491011917 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218491011918 heat shock protein HtpX; Provisional; Region: PRK05457 218491011919 Signal peptide predicted for ECA2427 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.423 between residues 63 and 64; signal peptide 218491011920 HMMPfam hit to PF01435, DE Peptidase family M48, score 2.4e-59 218491011921 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011922 4 probable transmembrane helices predicted for ECA2427 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 218491011923 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 218491011924 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 218491011925 putative active site [active] 218491011926 catalytic site [active] 218491011927 putative metal binding site [ion binding]; other site 218491011928 oligomer interface [polypeptide binding]; other site 218491011929 HMMPfam hit to PF03009, DE Glycerophosphoryl diester phosphodiesterase family, score 9.5e-13 218491011930 Signal peptide predicted for ECA2429 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.979 between residues 27 and 28; signal peptide 218491011931 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 218491011932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218491011933 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 2.2e-47 218491011934 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 218491011935 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 218491011936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491011937 putative substrate translocation pore; other site 218491011938 12 probable transmembrane helices predicted for ECA2430 by TMHMM2.0 at aa 9-31, 41-63, 76-93, 98-120, 133-155, 165-184, 216-235, 250-272, 279-301, 306-328, 341-363 and 367-386 218491011939 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 218491011940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491011941 active site 218491011942 phosphorylation site [posttranslational modification] 218491011943 intermolecular recognition site; other site 218491011944 dimerization interface [polypeptide binding]; other site 218491011945 LytTr DNA-binding domain; Region: LytTR; pfam04397 218491011946 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 4.8e-30 218491011947 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 218491011948 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 218491011949 GAF domain; Region: GAF_3; pfam13492 218491011950 Histidine kinase; Region: His_kinase; pfam06580 218491011951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491011952 ATP binding site [chemical binding]; other site 218491011953 Mg2+ binding site [ion binding]; other site 218491011954 G-X-G motif; other site 218491011955 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.4e-13 218491011956 6 probable transmembrane helices predicted for ECA2432 by TMHMM2.0 at aa 4-26, 46-65, 75-97, 109-128, 138-160 and 173-195 218491011957 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 218491011958 GAF domain; Region: GAF; pfam01590 218491011959 PAS domain S-box; Region: sensory_box; TIGR00229 218491011960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491011961 putative active site [active] 218491011962 heme pocket [chemical binding]; other site 218491011963 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491011964 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491011965 metal binding site [ion binding]; metal-binding site 218491011966 active site 218491011967 I-site; other site 218491011968 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491011969 HMMPfam hit to PF00563, DE EAL domain, score 2.2e-100 218491011970 PS00043 Bacterial regulatory proteins, gntR family signature. 218491011971 PS00017 ATP/GTP-binding site motif A (P-loop). 218491011972 HMMPfam hit to PF00990, DE GGDEF domain, score 3.2e-59 218491011973 HMMPfam hit to PF00785, DE PAC motif, score 0.00043 218491011974 HMMPfam hit to PF00989, DE PAS domain, score 3.1e-08 218491011975 HMMPfam hit to PF01590, DE GAF domain, score 9e-09 218491011976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491011977 non-specific DNA binding site [nucleotide binding]; other site 218491011978 salt bridge; other site 218491011979 Predicted transcriptional regulator [Transcription]; Region: COG2932 218491011980 sequence-specific DNA binding site [nucleotide binding]; other site 218491011981 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 218491011982 Catalytic site [active] 218491011983 HMMPfam hit to PF01381, DE Helix-turn-helix, score 1.9e-11 218491011984 Predicted helix-turn-helix motif with score 1592.000, SD 4.61 at aa 18-39, sequence LSQKALGDMIGVSQAAIQKIEV 218491011985 Mor transcription activator family; Region: Mor; pfam08765 218491011986 Predicted helix-turn-helix motif with score 1668.000, SD 4.87 at aa 80-101, sequence RNHSALAKKYNVSLQWIYKIVR 218491011987 4Fe-4S binding domain; Region: Fer4_5; pfam12801 218491011988 4Fe-4S binding domain; Region: Fer4_5; pfam12801 218491011989 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491011990 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 218491011991 5 probable transmembrane helices predicted for ECA2438 by TMHMM2.0 at aa 35-57, 92-114, 159-181, 196-218 and 325-347 218491011992 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00025 218491011993 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491011994 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.014 218491011995 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491011996 isocitrate dehydrogenase; Validated; Region: PRK07362 218491011997 isocitrate dehydrogenase; Reviewed; Region: PRK07006 218491011998 HMMPfam hit to PF00180, DE Isocitrate/isopropylmalate dehydrogenase, score 3.2e-152 218491011999 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 218491012000 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 218491012001 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 218491012002 active site 218491012003 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 1.5e-16 218491012004 PS01149 Rsu family of pseudouridine synthase signature. 218491012005 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 218491012006 nudix motif; other site 218491012007 HMMPfam hit to PF00293, DE NUDIX domain, score 1.4e-21 218491012008 PS00893 mutT domain signature. 218491012009 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 218491012010 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 218491012011 HMMPfam hit to PF03054, DE tRNA methyl transferase, score 5.2e-222 218491012012 putative lysogenization regulator; Reviewed; Region: PRK00218 218491012013 adenylosuccinate lyase; Provisional; Region: PRK09285 218491012014 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 218491012015 tetramer interface [polypeptide binding]; other site 218491012016 active site 218491012017 HMMPfam hit to PF00206, DE Lyase, score 1.6e-120 218491012018 PS00163 Fumarate lyases signature. 218491012019 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 218491012020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491012021 active site 218491012022 phosphorylation site [posttranslational modification] 218491012023 intermolecular recognition site; other site 218491012024 dimerization interface [polypeptide binding]; other site 218491012025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491012026 DNA binding site [nucleotide binding] 218491012027 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.4e-31 218491012028 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 7.1e-28 218491012029 Signal peptide predicted for ECA2446 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.535 between residues 28 and 29; signal peptide 218491012030 sensor protein PhoQ; Provisional; Region: PRK10815 218491012031 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 218491012032 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 218491012033 dimer interface [polypeptide binding]; other site 218491012034 phosphorylation site [posttranslational modification] 218491012035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491012036 ATP binding site [chemical binding]; other site 218491012037 Mg2+ binding site [ion binding]; other site 218491012038 G-X-G motif; other site 218491012039 2 probable transmembrane helices predicted for ECA2446 by TMHMM2.0 at aa 15-37 and 186-208 218491012040 HMMPfam hit to PF00672, DE HAMP domain, score 5e-09 218491012041 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 0.0038 218491012042 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.1e-23 218491012043 Uncharacterized conserved protein [Function unknown]; Region: COG2850 218491012044 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 218491012045 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 218491012046 metal binding site [ion binding]; metal-binding site 218491012047 dimer interface [polypeptide binding]; other site 218491012048 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 1.1e-22 218491012049 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 218491012050 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218491012051 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 218491012052 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 218491012053 Walker A/P-loop; other site 218491012054 ATP binding site [chemical binding]; other site 218491012055 Q-loop/lid; other site 218491012056 ABC transporter signature motif; other site 218491012057 Walker B; other site 218491012058 D-loop; other site 218491012059 H-loop/switch region; other site 218491012060 TOBE domain; Region: TOBE_2; pfam08402 218491012061 HMMPfam hit to PF00005, DE ABC transporter, score 1.5e-68 218491012062 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012063 PS00211 ABC transporters family signature. 218491012064 Signal peptide predicted for ECA2451 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.408 between residues 38 and 39; signal peptide 218491012065 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218491012066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491012067 dimer interface [polypeptide binding]; other site 218491012068 conserved gate region; other site 218491012069 putative PBP binding loops; other site 218491012070 ABC-ATPase subunit interface; other site 218491012071 6 probable transmembrane helices predicted for ECA2451 by TMHMM2.0 at aa 12-34, 72-94, 101-120, 152-174, 195-217 and 251-273 218491012072 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2e-15 218491012073 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491012074 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012075 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218491012076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491012077 dimer interface [polypeptide binding]; other site 218491012078 conserved gate region; other site 218491012079 putative PBP binding loops; other site 218491012080 ABC-ATPase subunit interface; other site 218491012081 6 probable transmembrane helices predicted for ECA2452 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 171-193 and 230-252 218491012082 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.9e-09 218491012083 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491012084 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 218491012085 Signal peptide predicted for ECA2453 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 22 and 23; signal peptide 218491012086 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 218491012087 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012088 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 1.3e-23 218491012089 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491012090 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 218491012091 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 218491012092 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218491012093 DNA binding site [nucleotide binding] 218491012094 active site 218491012095 HMMPfam hit to PF01035, DE 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 8.7e-31 218491012096 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 218491012097 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491012098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491012099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491012100 putative substrate translocation pore; other site 218491012101 11 probable transmembrane helices predicted for ECA2455 by TMHMM2.0 at aa 15-34, 41-60, 64-81, 102-124, 129-151, 176-198, 218-238, 245-262, 266-288, 300-322 and 327-349 218491012102 Helix-turn-helix domain; Region: HTH_18; pfam12833 218491012103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491012104 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 218491012105 substrate binding site [chemical binding]; other site 218491012106 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491012107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491012108 Predicted helix-turn-helix motif with score 1263.000, SD 3.49 at aa 207-228, sequence WTAQSAGRLLAMSEATLRRRLS 218491012109 PS00041 Bacterial regulatory proteins, araC family signature. 218491012110 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.00034 218491012111 Signal peptide predicted for ECA2459 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 21 and 22; signal peptide 218491012112 carboxy-terminal protease; Provisional; Region: PRK11186 218491012113 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 218491012114 protein binding site [polypeptide binding]; other site 218491012115 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 218491012116 Catalytic dyad [active] 218491012117 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 218491012118 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 7.5e-14 218491012119 ProP expression regulator; Provisional; Region: PRK04950 218491012120 ProQ/FINO family; Region: ProQ; smart00945 218491012121 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 218491012122 GAF domain; Region: GAF_2; pfam13185 218491012123 HMMPfam hit to PF01590, DE GAF domain, score 6.5e-08 218491012124 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 218491012125 Paraquat-inducible protein A; Region: PqiA; pfam04403 218491012126 Paraquat-inducible protein A; Region: PqiA; pfam04403 218491012127 8 probable transmembrane helices predicted for ECA2462 by TMHMM2.0 at aa 74-96, 124-146, 167-182, 192-214, 271-293, 321-343, 364-383 and 388-410 218491012128 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 218491012129 mce related protein; Region: MCE; pfam02470 218491012130 mce related protein; Region: MCE; pfam02470 218491012131 mce related protein; Region: MCE; pfam02470 218491012132 mce related protein; Region: MCE; pfam02470 218491012133 mce related protein; Region: MCE; pfam02470 218491012134 HMMPfam hit to PF02470, DE mce related protein, score 0.014 218491012135 1 probable transmembrane helix predicted for ECA2463 by TMHMM2.0 at aa 20-39 218491012136 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 218491012137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491012138 S-adenosylmethionine binding site [chemical binding]; other site 218491012139 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 218491012140 HMMPfam hit to PF01189, DE NOL1/NOP2/sun family, score 2.7e-38 218491012141 PS01153 NOL1/NOP2/sun family signature. 218491012142 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 218491012143 Signal peptide predicted for ECA2466 by SignalP 2.0 HMM (Signal peptide probabilty 0.850) with cleavage site probability 0.565 between residues 18 and 19; signal peptide 218491012144 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 218491012145 1 probable transmembrane helix predicted for ECA2467 by TMHMM2.0 at aa 7-26 218491012146 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 218491012147 Signal peptide predicted for ECA2468 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 22 and 23; signal peptide 218491012148 Signal peptide predicted for ECA2469 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.666 between residues 22 and 23; signal peptide 218491012149 Signal peptide predicted for ECA2470 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.936 between residues 20 and 21; signal peptide 218491012150 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 218491012151 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218491012152 DNA-binding site [nucleotide binding]; DNA binding site 218491012153 RNA-binding motif; other site 218491012154 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00313, DE 'Cold-shock' DNA-binding domain, score 2.6e-41 218491012155 PS00352 'Cold-shock' DNA-binding domain signature. 218491012156 Signal peptide predicted for ECA2472 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.846 between residues 20 and 21; signal peptide 218491012157 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 218491012158 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 218491012159 Ferritin-like domain; Region: Ferritin; pfam00210 218491012160 ferroxidase diiron center [ion binding]; other site 218491012161 HMMPfam hit to PF00210, DE Ferritin-like domain, score 1e-44 218491012162 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 218491012163 protease 2; Provisional; Region: PRK10115 218491012164 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218491012165 HMMPfam hit to PF00326, DE Prolyl oligopeptidase family, score 1.8e-32 218491012166 HMMPfam hit to PF02897, DE Prolyl oligopeptidase, N-terminal beta-propeller domain, score 1.5e-129 218491012167 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 218491012168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491012169 ATP-grasp domain; Region: ATP-grasp; pfam02222 218491012170 HMMPfam hit to PF02222, DE ATP-grasp domain, score 1.8e-41 218491012171 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 218491012172 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 218491012173 active site 218491012174 intersubunit interface [polypeptide binding]; other site 218491012175 catalytic residue [active] 218491012176 HMMPfam hit to PF01081, DE KDPG and KHG aldolase, score 8.6e-130 218491012177 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 218491012178 PS00159 KDPG and KHG aldolases active site. 218491012179 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 218491012180 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 218491012181 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 218491012182 HMMPfam hit to PF02781, DE Glucose-6-phosphate dehydrogenase, C-terminal domain, score 1.2e-189 218491012183 HMMPfam hit to PF00479, DE Glucose-6-phosphate dehydrogenase, NAD binding domain, score 1.7e-96 218491012184 PS00069 Glucose-6-phosphate dehydrogenase active site. 218491012185 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 218491012186 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218491012187 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218491012188 putative active site [active] 218491012189 HMMPfam hit to PF01418, DE Helix-turn-helix domain, rpiR family, score 4.2e-48 218491012190 Predicted helix-turn-helix motif with score 1545.000, SD 4.45 at aa 35-56, sequence SSIATLAKMADVSEPTVNRFCR 218491012191 HMMPfam hit to PF01380, DE SIS domain, score 5.2e-37 218491012192 pyruvate kinase; Provisional; Region: PRK05826 218491012193 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 218491012194 domain interfaces; other site 218491012195 active site 218491012196 HMMPfam hit to PF00224, DE Pyruvate kinase, barrel domain, score 2.4e-219 218491012197 PS00110 Pyruvate kinase active site signature. 218491012198 HMMPfam hit to PF02887, DE Pyruvate kinase, alpha/beta domain, score 3.1e-55 218491012199 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 218491012200 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218491012201 putative acyl-acceptor binding pocket; other site 218491012202 HMMPfam hit to PF03279, DE Bacterial lipid A biosynthesis acyltransferase, score 2.6e-131 218491012203 1 probable transmembrane helix predicted for ECA2482 by TMHMM2.0 at aa 32-50 218491012204 putative peptidase; Provisional; Region: PRK11649 218491012205 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 218491012206 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218491012207 Peptidase family M23; Region: Peptidase_M23; pfam01551 218491012208 HMMPfam hit to PF01551, DE Peptidase family M23/M37, score 7.8e-41 218491012209 HMMPfam hit to PF01476, DE LysM domain, score 5.7e-05 218491012210 1 probable transmembrane helix predicted for ECA2483 by TMHMM2.0 at aa 21-40 218491012211 Signal peptide predicted for ECA2484 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.875 between residues 32 and 33; signal peptide 218491012212 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 218491012213 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 218491012214 metal binding site [ion binding]; metal-binding site 218491012215 HMMPfam hit to PF01297, DE Periplasmic solute binding protein family, score 2.7e-32 218491012216 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012217 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 218491012218 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218491012219 HMMPfam hit to PF00005, DE ABC transporter, score 1.3e-46 218491012220 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012221 Signal peptide predicted for ECA2486 by SignalP 2.0 HMM (Signal peptide probabilty 0.792) with cleavage site probability 0.596 between residues 18 and 19; signal peptide 218491012222 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218491012223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491012224 ABC-ATPase subunit interface; other site 218491012225 dimer interface [polypeptide binding]; other site 218491012226 putative PBP binding regions; other site 218491012227 HMMPfam hit to PF00950, DE ABC 3 transport family, score 2.3e-110 218491012228 7 probable transmembrane helices predicted for ECA2486 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145, 178-200, 213-235 and 239-256 218491012229 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491012230 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491012231 DNA binding site [nucleotide binding] 218491012232 domain linker motif; other site 218491012233 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 218491012234 ligand binding site [chemical binding]; other site 218491012235 dimerization interface [polypeptide binding]; other site 218491012236 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.46 218491012237 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 8.7e-10 218491012238 Predicted helix-turn-helix motif with score 1759.000, SD 5.18 at aa 43-64, sequence STINDVSRLAGVSKATVSRVLS 218491012239 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 218491012240 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 218491012241 10 probable transmembrane helices predicted for ECA2488 by TMHMM2.0 at aa 53-75, 100-122, 129-146, 156-178, 199-221, 231-253, 258-280, 302-324, 356-378 and 410-432 218491012242 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 0.088 218491012243 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218491012244 methionine cluster; other site 218491012245 active site 218491012246 phosphorylation site [posttranslational modification] 218491012247 metal binding site [ion binding]; metal-binding site 218491012248 HMMPfam hit to PF02255, DE PTS system, Lactose/Cellobiose specific IIA subunit, score 1.8e-37 218491012249 Signal peptide predicted for ECA2490 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25; signal peptide 218491012250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 218491012251 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 218491012252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491012253 Walker A motif; other site 218491012254 ATP binding site [chemical binding]; other site 218491012255 Walker B motif; other site 218491012256 arginine finger; other site 218491012257 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 218491012258 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 1.8e-29 218491012259 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012260 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 218491012261 RuvA N terminal domain; Region: RuvA_N; pfam01330 218491012262 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 218491012263 HMMPfam hit to PF02904, , score 7.7e-39 218491012264 HMMPfam hit to PF01330, DE RuvA N terminal domain, score 1.4e-31 218491012265 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 218491012266 active site 218491012267 putative DNA-binding cleft [nucleotide binding]; other site 218491012268 dimer interface [polypeptide binding]; other site 218491012269 HMMPfam hit to PF02075, DE Crossover junction endodeoxyribonuclease RuvC, score 3e-91 218491012270 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 218491012271 hypothetical protein; Validated; Region: PRK00110 218491012272 HMMPfam hit to PF01709, DE Domain of unknown function DUF28, score 6.2e-140 218491012273 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 218491012274 nudix motif; other site 218491012275 HMMPfam hit to PF00293, DE NUDIX domain, score 2.2e-24 218491012276 PS00893 mutT domain signature. 218491012277 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 218491012278 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 218491012279 dimer interface [polypeptide binding]; other site 218491012280 anticodon binding site; other site 218491012281 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 218491012282 homodimer interface [polypeptide binding]; other site 218491012283 motif 1; other site 218491012284 active site 218491012285 motif 2; other site 218491012286 GAD domain; Region: GAD; pfam02938 218491012287 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218491012288 active site 218491012289 motif 3; other site 218491012290 HMMPfam hit to PF00152, DE tRNA synthetases class II (D, K and N), score 9.2e-15 218491012291 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491012292 HMMPfam hit to PF02938, DE GAD domain, score 4e-51 218491012293 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491012294 HMMPfam hit to PF01336, DE OB-fold nucleic acid binding domain, score 5.5e-12 218491012295 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 218491012296 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491012297 HMMPfam hit to PF00563, DE EAL domain, score 0.00039 218491012298 Protein of unknown function DUF72; Region: DUF72; cl00777 218491012299 PS00107 Protein kinases ATP-binding region signature. 218491012300 Predicted helix-turn-helix motif with score 1054.000, SD 2.78 at aa 287-308, sequence VNQTDAMKQAAVLKQTMSQAFS 218491012301 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 218491012302 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 218491012303 catalytic residues [active] 218491012304 catalytic nucleophile [active] 218491012305 Predicted helix-turn-helix motif with score 1070.000, SD 2.83 at aa 180-201, sequence MSYSDIMDTVECSRATIAKVSN 218491012306 HMMPfam hit to PF00239, DE Resolvase, N terminal domain, score 2.8e-17 218491012307 PS00398 Site-specific recombinases signature 2. 218491012308 PS00397 Site-specific recombinases active site. 218491012309 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 218491012310 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 218491012311 catalytic residues [active] 218491012312 catalytic nucleophile [active] 218491012313 Recombinase; Region: Recombinase; pfam07508 218491012314 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 218491012315 Protein of unknown function DUF72; Region: DUF72; cl00777 218491012316 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 218491012317 4 probable transmembrane helices predicted for ECA2510 by TMHMM2.0 at aa 4-22, 43-65, 70-92 and 105-124 218491012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491012319 S-adenosylmethionine binding site [chemical binding]; other site 218491012320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491012321 S-adenosylmethionine binding site [chemical binding]; other site 218491012322 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 218491012323 putative active site [active] 218491012324 copper homeostasis protein CutC; Provisional; Region: PRK11572 218491012325 HMMPfam hit to PF03932, DE CutC family, score 1.3e-93 218491012326 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 218491012327 putative metal binding site [ion binding]; other site 218491012328 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 218491012329 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 218491012330 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 218491012331 active site 218491012332 HIGH motif; other site 218491012333 KMSK motif region; other site 218491012334 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 218491012335 tRNA binding surface [nucleotide binding]; other site 218491012336 anticodon binding site; other site 218491012337 HMMPfam hit to PF03485, DE Arginyl tRNA synthetase N terminal domain, score 2.6e-28 218491012338 HMMPfam hit to PF00750, DE tRNA synthetases class I (R), score 5.2e-194 218491012339 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491012340 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 218491012341 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 218491012342 13 probable transmembrane helices predicted for ECA2521 by TMHMM2.0 at aa 26-45, 88-110, 130-152, 159-181, 186-203, 232-254, 274-296, 309-328, 353-375, 382-404, 408-430, 443-465 and 478-500 218491012343 HMMPfam hit to PF03023, DE MviN-like protein, score 5.5e-204 218491012344 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218491012345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 218491012346 HMMPfam hit to PF02894, DE Oxidoreductase family, C-terminal alpha/beta domain, score 0.2 218491012347 HMMPfam hit to PF01408, DE Oxidoreductase family, NAD-binding Rossmann fold, score 2.8e-30 218491012348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 218491012349 hypothetical protein; Provisional; Region: PRK11239 218491012350 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012351 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 218491012352 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 218491012353 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.5e-09 218491012354 multidrug resistance protein MdtH; Provisional; Region: PRK11646 218491012355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491012356 putative substrate translocation pore; other site 218491012357 10 probable transmembrane helices predicted for ECA2525 by TMHMM2.0 at aa 13-35, 99-116, 136-158, 168-190, 210-232, 247-264, 277-295, 300-322, 335-357 and 367-389 218491012358 glutaredoxin 2; Provisional; Region: PRK10387 218491012359 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 218491012360 C-terminal domain interface [polypeptide binding]; other site 218491012361 GSH binding site (G-site) [chemical binding]; other site 218491012362 catalytic residues [active] 218491012363 putative dimer interface [polypeptide binding]; other site 218491012364 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 218491012365 N-terminal domain interface [polypeptide binding]; other site 218491012366 PS00195 Glutaredoxin active site. 218491012367 Signal peptide predicted for ECA2527 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.431 between residues 20 and 21; signal peptide 218491012368 lipoprotein; Provisional; Region: PRK10598 218491012369 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012370 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 218491012371 putative hydrolase; Validated; Region: PRK09248 218491012372 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 218491012373 active site 218491012374 HMMPfam hit to PF02811, DE PHP domain C-terminal region, score 2.1e-06 218491012375 HMMPfam hit to PF02231, DE PHP domain N-terminal region, score 5e-16 218491012376 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 218491012377 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491012378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491012379 dimer interface [polypeptide binding]; other site 218491012380 putative CheW interface [polypeptide binding]; other site 218491012381 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 7e-105 218491012382 2 probable transmembrane helices predicted for ECA2530 by TMHMM2.0 at aa 52-74 and 219-241 218491012383 Signal peptide predicted for ECA2531 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.722 between residues 21 and 22; signal peptide 218491012384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 218491012385 Protein of unknown function (DUF330); Region: DUF330; pfam03886 218491012386 HMMPfam hit to PF03886, DE Protein of unknown function (DUF330), score 1.5e-57 218491012387 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012388 paraquat-inducible protein B; Provisional; Region: PRK10807 218491012389 mce related protein; Region: MCE; pfam02470 218491012390 mce related protein; Region: MCE; pfam02470 218491012391 mce related protein; Region: MCE; pfam02470 218491012392 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 218491012393 1 probable transmembrane helix predicted for ECA2532 by TMHMM2.0 at aa 26-48 218491012394 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 218491012395 Paraquat-inducible protein A; Region: PqiA; pfam04403 218491012396 Paraquat-inducible protein A; Region: PqiA; pfam04403 218491012397 8 probable transmembrane helices predicted for ECA2533 by TMHMM2.0 at aa 75-97, 125-147, 168-190, 194-212, 280-302, 317-339, 376-398 and 403-425 218491012398 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012399 ABC transporter ATPase component; Reviewed; Region: PRK11147 218491012400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491012401 Walker A/P-loop; other site 218491012402 ATP binding site [chemical binding]; other site 218491012403 Q-loop/lid; other site 218491012404 ABC transporter signature motif; other site 218491012405 Walker B; other site 218491012406 D-loop; other site 218491012407 H-loop/switch region; other site 218491012408 ABC transporter; Region: ABC_tran_2; pfam12848 218491012409 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491012410 HMMPfam hit to PF00005, DE ABC transporter, score 1.5e-37 218491012411 PS00211 ABC transporters family signature. 218491012412 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012413 HMMPfam hit to PF00005, DE ABC transporter, score 1.4e-45 218491012414 PS00211 ABC transporters family signature. 218491012415 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012416 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 218491012417 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 218491012418 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 218491012419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491012420 S-adenosylmethionine binding site [chemical binding]; other site 218491012421 HMMPfam hit to PF01170, DE RNA methylase family UPF0020, score 6.8e-86 218491012422 PS00092 N-6 Adenine-specific DNA methylases signature. 218491012423 PS01261 Uncharacterized protein family UPF0020 signature. 218491012424 HMMPfam hit to PF02926, DE THUMP domain, score 5e-14 218491012425 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 218491012426 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 218491012427 MOSC domain; Region: MOSC; pfam03473 218491012428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218491012429 catalytic loop [active] 218491012430 iron binding site [ion binding]; other site 218491012431 HMMPfam hit to PF03476, DE MOSC N-terminal beta barrel domain, score 5.3e-40 218491012432 HMMPfam hit to PF03473, DE MOSC domain, score 5.2e-48 218491012433 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 3.5e-08 218491012434 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 218491012435 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 218491012436 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 218491012437 quinone interaction residues [chemical binding]; other site 218491012438 active site 218491012439 catalytic residues [active] 218491012440 FMN binding site [chemical binding]; other site 218491012441 substrate binding site [chemical binding]; other site 218491012442 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01180, DE Dihydroorotate dehydrogenase, score 1.4e-156 218491012443 PS00912 Dihydroorotate dehydrogenase signature 2. 218491012444 PS00911 Dihydroorotate dehydrogenase signature 1. 218491012445 aminopeptidase N; Provisional; Region: pepN; PRK14015 218491012446 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 218491012447 active site 218491012448 Zn binding site [ion binding]; other site 218491012449 HMMPfam hit to PF01433, DE Peptidase family M1, score 4e-70 218491012450 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491012451 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 218491012452 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 218491012453 active site 218491012454 Predicted helix-turn-helix motif with score 999.000, SD 2.59 at aa 202-223, sequence TSNYDLARRLGITPVGTQAHEW 218491012455 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 218491012456 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 218491012457 putative dimer interface [polypeptide binding]; other site 218491012458 putative anticodon binding site; other site 218491012459 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 218491012460 homodimer interface [polypeptide binding]; other site 218491012461 motif 1; other site 218491012462 motif 2; other site 218491012463 active site 218491012464 motif 3; other site 218491012465 HMMPfam hit to PF01336, DE OB-fold nucleic acid binding domain, score 1.7e-10 218491012466 HMMPfam hit to PF00152, DE tRNA synthetases class II (D, K and N), score 1.9e-166 218491012467 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491012468 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491012469 Signal peptide predicted for ECA2542 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23; signal peptide 218491012470 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 218491012471 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 218491012472 trimer interface [polypeptide binding]; other site 218491012473 eyelet of channel; other site 218491012474 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00267, DE Gram-negative porin, score 1e-161 218491012475 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 218491012476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491012477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491012478 homodimer interface [polypeptide binding]; other site 218491012479 catalytic residue [active] 218491012480 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 5.8e-107 218491012481 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218491012482 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 218491012483 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 3.3e-46 218491012484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 218491012485 Signal peptide predicted for ECA2545 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.977 between residues 30 and 31; signal peptide 218491012486 Peptidase M15; Region: Peptidase_M15_3; cl01194 218491012487 Signal peptide predicted for ECA2546 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 32 and 33; signal peptide 218491012488 murein L,D-transpeptidase; Provisional; Region: PRK10594 218491012489 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 218491012490 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 218491012491 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 218491012492 active site 218491012493 PS00092 N-6 Adenine-specific DNA methylases signature. 218491012494 cell division protein MukB; Provisional; Region: mukB; PRK04863 218491012495 P-loop containing region of AAA domain; Region: AAA_29; cl17516 218491012496 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 218491012497 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012498 condesin subunit E; Provisional; Region: PRK05256 218491012499 condesin subunit F; Provisional; Region: PRK05260 218491012500 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03882, DE KicB killing factor, score 0 218491012501 Methyltransferase domain; Region: Methyltransf_31; pfam13847 218491012502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491012503 S-adenosylmethionine binding site [chemical binding]; other site 218491012504 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012505 Uncharacterized conserved protein [Function unknown]; Region: COG1434 218491012506 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218491012507 putative active site [active] 218491012508 HMMPfam hit to PF02698, DE Uncharacterized ACR, COG1434, score 4.7e-95 218491012509 1 probable transmembrane helix predicted for ECA2551 by TMHMM2.0 at aa 10-32 218491012510 hypothetical protein; Provisional; Region: PRK10593 218491012511 Right handed beta helix region; Region: Beta_helix; pfam13229 218491012512 2 probable transmembrane helices predicted for ECA2553 by TMHMM2.0 at aa 4-26 and 38-60 218491012513 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 218491012514 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 218491012515 Ligand binding site; other site 218491012516 oligomer interface; other site 218491012517 HMMPfam hit to PF02348, DE Cytidylyltransferase, score 1.4e-87 218491012518 Trm112p-like protein; Region: Trm112p; cl01066 218491012519 HMMPfam hit to PF03966, DE Protein of unknown function (DUF343), score 5.2e-23 218491012520 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 218491012521 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 218491012522 HMMPfam hit to PF02606, DE Tetraacyldisaccharide-1-P 4'-kinase, score 2.9e-140 218491012523 1 probable transmembrane helix predicted for ECA2556 by TMHMM2.0 at aa 12-34 218491012524 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 218491012525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491012526 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 218491012527 Walker A/P-loop; other site 218491012528 ATP binding site [chemical binding]; other site 218491012529 Q-loop/lid; other site 218491012530 ABC transporter signature motif; other site 218491012531 Walker B; other site 218491012532 D-loop; other site 218491012533 H-loop/switch region; other site 218491012534 HMMPfam hit to PF00005, DE ABC transporter, score 2e-64 218491012535 PS00211 ABC transporters family signature. 218491012536 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012537 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 1.4e-62 218491012538 5 probable transmembrane helices predicted for ECA2557 by TMHMM2.0 at aa 37-59, 74-96, 116-133, 170-192 and 257-279 218491012539 ComEC family competence protein; Provisional; Region: PRK11539 218491012540 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 218491012541 Competence protein; Region: Competence; pfam03772 218491012542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 218491012543 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 0.0018 218491012544 10 probable transmembrane helices predicted for ECA2558 by TMHMM2.0 at aa 20-42, 49-71, 225-247, 260-282, 332-349, 362-381, 385-407, 412-434, 449-471 and 478-495 218491012545 HMMPfam hit to PF03772, DE Competence protein, score 3e-48 218491012546 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012547 Transposase IS200 like; Region: Y1_Tnp; pfam01797 218491012548 HMMPfam hit to PF01797, DE Transposase IS200 like, score 2.3e-64 218491012549 hypothetical protein; Provisional; Region: PRK05423 218491012550 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 218491012551 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491012552 Walker A/P-loop; other site 218491012553 ATP binding site [chemical binding]; other site 218491012554 Q-loop/lid; other site 218491012555 ABC transporter signature motif; other site 218491012556 Walker B; other site 218491012557 D-loop; other site 218491012558 H-loop/switch region; other site 218491012559 HMMPfam hit to PF00005, DE ABC transporter, score 1.5e-50 218491012560 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012561 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491012563 ABC-ATPase subunit interface; other site 218491012564 dimer interface [polypeptide binding]; other site 218491012565 putative PBP binding regions; other site 218491012566 HMMPfam hit to PF01032, DE FecCD transport family, score 6.6e-11 218491012567 9 probable transmembrane helices predicted for ECA2562 by TMHMM2.0 at aa 27-44, 59-78, 91-113, 123-142, 149-171, 191-213, 242-264, 284-303 and 310-329 218491012568 Signal peptide predicted for ECA2563 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.950 between residues 25 and 26; signal peptide 218491012569 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491012570 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491012571 ABC-ATPase subunit interface; other site 218491012572 dimer interface [polypeptide binding]; other site 218491012573 putative PBP binding regions; other site 218491012574 8 probable transmembrane helices predicted for ECA2563 by TMHMM2.0 at aa 4-26, 51-73, 88-122, 134-156, 176-198, 228-250, 265-287 and 294-313 218491012575 HMMPfam hit to PF01032, DE FecCD transport family, score 8.6e-35 218491012576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012577 Signal peptide predicted for ECA2564 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.384 between residues 29 and 30; signal peptide 218491012578 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 218491012579 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 218491012580 putative ligand binding residues [chemical binding]; other site 218491012581 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 6.8e-48 218491012582 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012583 exonuclease I; Provisional; Region: sbcB; PRK11779 218491012584 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 218491012585 active site 218491012586 catalytic site [active] 218491012587 substrate binding site [chemical binding]; other site 218491012588 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 218491012589 HMMPfam hit to PF00929, DE Exonuclease, score 6.4e-31 218491012590 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 218491012591 HMMPfam hit to PF00324, DE Amino acid permease, score 2e-08 218491012592 12 probable transmembrane helices predicted for ECA2566 by TMHMM2.0 at aa 23-42, 57-79, 100-122, 137-159, 164-186, 206-223, 244-266, 293-315, 344-363, 367-389, 402-421 and 426-443 218491012593 Flagellar regulator YcgR; Region: YcgR; pfam07317 218491012594 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 218491012595 PilZ domain; Region: PilZ; pfam07238 218491012596 PS00018 EF-hand calcium-binding domain. 218491012597 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 218491012598 HMMPfam hit to PF01874, DE ATP:dephospho-CoA triphosphoribosyl transferase, score 1.4e-96 218491012599 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 218491012600 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03802, DE Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, score 1.9e-46 218491012601 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 218491012602 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012603 Signal peptide predicted for ECA2572 by SignalP 2.0 HMM (Signal peptide probabilty 0.932) with cleavage site probability 0.565 between residues 22 and 23; signal peptide 218491012604 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 218491012605 citrate lyase subunit gamma; Provisional; Region: PRK13253 218491012606 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 218491012607 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 218491012608 putative active site [active] 218491012609 (T/H)XGH motif; other site 218491012610 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 8.1e-09 218491012611 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 218491012612 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 218491012613 HMMPfam hit to PF01557, DE Fumarylacetoacetate (FAA) hydrolase family, score 1.8e-37 218491012614 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 218491012615 12 probable transmembrane helices predicted for ECA2576 by TMHMM2.0 at aa 34-51, 61-80, 87-109, 124-141, 154-176, 186-208, 217-239, 282-299, 306-328, 343-365, 372-391 and 433-455 218491012616 HMMPfam hit to PF03390, DE Bacterial sodium:citrate symporter, score 7.6e-144 218491012617 Signal peptide predicted for ECA2577 by SignalP 2.0 HMM (Signal peptide probabilty 0.647) with cleavage site probability 0.411 between residues 26 and 27; signal peptide 218491012618 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 218491012619 PAS domain; Region: PAS; smart00091 218491012620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491012621 ATP binding site [chemical binding]; other site 218491012622 Mg2+ binding site [ion binding]; other site 218491012623 G-X-G motif; other site 218491012624 3 probable transmembrane helices predicted for ECA2577 by TMHMM2.0 at aa 7-29, 140-157 and 169-191 218491012625 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 3.7e-19 218491012626 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 218491012627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491012628 active site 218491012629 phosphorylation site [posttranslational modification] 218491012630 intermolecular recognition site; other site 218491012631 dimerization interface [polypeptide binding]; other site 218491012632 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.3e-16 218491012633 Predicted helix-turn-helix motif with score 991.000, SD 2.56 at aa 182-203, sequence YSVDDIVEQTGLSKTTARRYLE 218491012634 Signal peptide predicted for ECA2579 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.594 between residues 35 and 36; signal peptide 218491012635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491012636 dimerization interface [polypeptide binding]; other site 218491012637 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491012638 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491012639 dimer interface [polypeptide binding]; other site 218491012640 putative CheW interface [polypeptide binding]; other site 218491012641 2 probable transmembrane helices predicted for ECA2579 by TMHMM2.0 at aa 15-37 and 278-300 218491012642 HMMPfam hit to PF03915, DE Actin interacting protein 3, score 6.2 218491012643 HMMPfam hit to PF00672, DE HAMP domain, score 2.7e-08 218491012644 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 4.9e-97 218491012645 Signal peptide predicted for ECA2580 by SignalP 2.0 HMM (Signal peptide probabilty 0.904) with cleavage site probability 0.407 between residues 35 and 36; signal peptide 218491012646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491012647 dimerization interface [polypeptide binding]; other site 218491012648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491012649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491012650 dimer interface [polypeptide binding]; other site 218491012651 putative CheW interface [polypeptide binding]; other site 218491012652 2 probable transmembrane helices predicted for ECA2580 by TMHMM2.0 at aa 20-42 and 283-305 218491012653 HMMPfam hit to PF00672, DE HAMP domain, score 9.8e-09 218491012654 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 5.5e-93 218491012655 Signal peptide predicted for ECA2581 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.929 between residues 19 and 20; signal peptide 218491012656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 218491012657 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 218491012658 putative NAD(P) binding site [chemical binding]; other site 218491012659 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012660 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 218491012661 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 218491012662 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 218491012663 HMMPfam hit to PF01634, DE ATP phosphoribosyltransferase, score 6e-78 218491012664 PS01316 ATP phosphoribosyltransferase signature. 218491012665 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 218491012666 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 218491012667 NAD binding site [chemical binding]; other site 218491012668 dimerization interface [polypeptide binding]; other site 218491012669 product binding site; other site 218491012670 substrate binding site [chemical binding]; other site 218491012671 zinc binding site [ion binding]; other site 218491012672 catalytic residues [active] 218491012673 HMMPfam hit to PF00815, DE Histidinol dehydrogenase, score 1.8e-253 218491012674 PS00611 Histidinol dehydrogenase signature. 218491012675 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 218491012676 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491012677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491012678 homodimer interface [polypeptide binding]; other site 218491012679 catalytic residue [active] 218491012680 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 5.1e-58 218491012681 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 218491012682 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 218491012683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491012684 active site 218491012685 motif I; other site 218491012686 motif II; other site 218491012687 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 218491012688 putative active site pocket [active] 218491012689 4-fold oligomerization interface [polypeptide binding]; other site 218491012690 metal binding residues [ion binding]; metal-binding site 218491012691 3-fold/trimer interface [polypeptide binding]; other site 218491012692 HMMPfam hit to PF00475, DE Imidazoleglycerol-phosphate dehydratase, score 1.2e-100 218491012693 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 218491012694 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 218491012695 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 218491012696 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 218491012697 putative active site [active] 218491012698 oxyanion strand; other site 218491012699 catalytic triad [active] 218491012700 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 3.6e-39 218491012701 PS00442 Glutamine amidotransferases class-I active site. 218491012702 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 218491012703 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 218491012704 catalytic residues [active] 218491012705 HMMPfam hit to PF00977, DE Histidine biosynthesis protein, score 2.4e-51 218491012706 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 218491012707 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 218491012708 substrate binding site [chemical binding]; other site 218491012709 glutamase interaction surface [polypeptide binding]; other site 218491012710 HMMPfam hit to PF00977, DE Histidine biosynthesis protein, score 8.6e-138 218491012711 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 218491012712 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 218491012713 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 218491012714 metal binding site [ion binding]; metal-binding site 218491012715 HMMPfam hit to PF01502, DE Phosphoribosyl-AMP cyclohydrolase, score 1.5e-40 218491012716 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491012717 HMMPfam hit to PF01503, DE Phosphoribosyl-ATP pyrophosphohydrolase, score 3.5e-44 218491012718 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218491012719 IHF dimer interface [polypeptide binding]; other site 218491012720 IHF - DNA interface [nucleotide binding]; other site 218491012721 HMMPfam hit to PF00216, DE Bacterial DNA-binding protein, score 4.4e-45 218491012722 PS00045 Bacterial histone-like DNA-binding proteins signature. 218491012723 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 218491012724 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 218491012725 RNA binding site [nucleotide binding]; other site 218491012726 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 218491012727 RNA binding site [nucleotide binding]; other site 218491012728 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 218491012729 RNA binding site [nucleotide binding]; other site 218491012730 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 218491012731 RNA binding site [nucleotide binding]; other site 218491012732 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 218491012733 RNA binding site [nucleotide binding]; other site 218491012734 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 218491012735 RNA binding site [nucleotide binding]; other site 218491012736 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 7.9e-20 218491012737 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 4.3e-25 218491012738 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 4.2e-28 218491012739 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 5.5e-31 218491012740 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 4.5e-17 218491012741 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 5.1e-11 218491012742 cytidylate kinase; Provisional; Region: cmk; PRK00023 218491012743 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 218491012744 CMP-binding site; other site 218491012745 The sites determining sugar specificity; other site 218491012746 HMMPfam hit to PF02224, DE Cytidylate kinase, score 1.7e-86 218491012747 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 218491012748 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 218491012749 hinge; other site 218491012750 active site 218491012751 HMMPfam hit to PF00275, DE EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 1.7e-215 218491012752 PS00885 EPSP synthase signature 2. 218491012753 PS00104 EPSP synthase signature 1. 218491012754 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012755 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 218491012756 homodimer interface [polypeptide binding]; other site 218491012757 substrate-cofactor binding pocket; other site 218491012758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491012759 catalytic residue [active] 218491012760 HMMPfam hit to PF00266, DE Aminotransferase class-V, score 4.7e-108 218491012761 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218491012762 uncharacterized domain; Region: TIGR00702 218491012763 YcaO-like family; Region: YcaO; pfam02624 218491012764 HMMPfam hit to PF02624, DE Uncharacterized ACR, COG1944, score 1.1e-234 218491012765 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012766 formate transporter; Provisional; Region: PRK10805 218491012767 HMMPfam hit to PF01226, DE Formate/nitrite transporter, score 3.5e-155 218491012768 6 probable transmembrane helices predicted for ECA2596 by TMHMM2.0 at aa 35-57, 77-99, 112-134, 161-183, 195-217 and 256-278 218491012769 PS01005 Formate and nitrite transporters signature 1. 218491012770 PS01006 Formate and nitrite transporters signature 2. 218491012771 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 218491012772 Pyruvate formate lyase 1; Region: PFL1; cd01678 218491012773 coenzyme A binding site [chemical binding]; other site 218491012774 active site 218491012775 catalytic residues [active] 218491012776 glycine loop; other site 218491012777 HMMPfam hit to PF02901, DE Pyruvate formate lyase, score 0 218491012778 HMMPfam hit to PF01228, DE Glycine radical, score 1.8e-67 218491012779 PS00850 Glycine radical signature. 218491012780 Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri pyruvate formate-lyase 1 activating enzyme PflA or Act or b0902 or c1038 or z1246 or ecs0985 or sf0897 or s0961 SWALL:PFLA_ECOLI (SWALL:P09374) (245 aa) fasta scores: E(): 4.4e-94, 89.38% id in 245 aa, and to Yersinia pestis pyruvate formate-lyase 1 activating enzyme PflA or ypo1381 SWALL:Q8ZGC2 (EMBL:AJ414148) (244 aa) fasta scores: E(): 1.1e-93, 89.34% id in 244 aa. CDS is interupted by the insertion of a bacteriophage after codon 5;pyruvate formate-lyase 1 activating enzyme (pseudogene) 218491012781 Complete P2-family prophage denoted phi ECA29 218491012782 Signal peptide predicted for ECA2598 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.813 between residues 20 and 21; signal peptide 218491012783 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218491012784 tail protein; Provisional; Region: D; PHA02561 218491012785 major tail sheath protein; Provisional; Region: FI; PHA02560 218491012786 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012787 Phage tail tube protein FII; Region: Phage_tube; pfam04985 218491012788 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 218491012789 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 218491012790 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 218491012791 4 probable transmembrane helices predicted for ECA2605 by TMHMM2.0 at aa 527-549, 556-578, 635-657 and 664-686 218491012792 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 218491012793 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 218491012794 HMMPfam hit to PF02413, DE Caudovirales tail fibre assembly protein, score 1.9e-24 218491012795 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 218491012796 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 218491012797 Signal peptide predicted for ECA2608 by SignalP 2.0 HMM (Signal peptide probabilty 0.887) with cleavage site probability 0.720 between residues 20 and 21; signal peptide 218491012798 Phage Tail Collar Domain; Region: Collar; pfam07484 218491012799 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 218491012800 Baseplate J-like protein; Region: Baseplate_J; cl01294 218491012801 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 218491012802 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 218491012803 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 218491012804 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 218491012805 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 218491012806 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 218491012807 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 218491012808 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 218491012809 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 218491012810 Phage holin family 2; Region: Phage_holin_2; pfam04550 218491012811 3 probable transmembrane helices predicted for ECA2617 by TMHMM2.0 at aa 12-31, 38-60 and 65-87 218491012812 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 218491012813 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 218491012814 terminase endonuclease subunit; Provisional; Region: M; PHA02537 218491012815 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 218491012816 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 218491012817 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 218491012818 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 218491012819 terminase ATPase subunit; Provisional; Region: P; PHA02535 218491012820 Predicted helix-turn-helix motif with score 1903.000, SD 5.67 at aa 20-41, sequence YPPAEISRLMGINQNTVYAWKK 218491012821 Phage-related protein [Function unknown]; Region: COG4695; cl01923 218491012822 Phage portal protein; Region: Phage_portal; pfam04860 218491012823 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 218491012824 PS00092 N-6 Adenine-specific DNA methylases signature. 218491012825 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 218491012826 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 218491012827 PS00539 Pyrokinins signature. 218491012828 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218491012829 Active Sites [active] 218491012830 HMMPfam hit to PF01507, DE Phosphoadenosine phosphosulfate reductase family, score 4.7e-30 218491012831 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 218491012832 HMMPfam hit to PF02086, DE D12 class N6 adenine-specific DNA methyltransferase, score 1.4e-77 218491012833 PS00092 N-6 Adenine-specific DNA methylases signature. 218491012834 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 218491012835 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 218491012836 active site 218491012837 catalytic site [active] 218491012838 substrate binding site [chemical binding]; other site 218491012839 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 218491012840 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 218491012841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491012842 non-specific DNA binding site [nucleotide binding]; other site 218491012843 salt bridge; other site 218491012844 sequence-specific DNA binding site [nucleotide binding]; other site 218491012845 HMMPfam hit to PF01381, DE Helix-turn-helix, score 0.0002 218491012846 Predicted helix-turn-helix motif with score 1087.000, SD 2.89 at aa 18-39, sequence LKKKEVADMTGINYVTYVGYEN 218491012847 integrase; Provisional; Region: int; PHA02601 218491012848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491012849 active site 218491012850 DNA binding site [nucleotide binding] 218491012851 Int/Topo IB signature motif; other site 218491012852 HMMPfam hit to PF00589, DE Phage integrase family, score 4.3e-30 218491012853 HMMPfam hit to PF02143, , score 5.1e-14 218491012854 PS01087 Radical activating enzymes signature. 218491012855 PS00190 Cytochrome c family heme-binding site signature. 218491012856 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 218491012857 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 218491012858 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 218491012859 HMMPfam hit to PF01968, DE Hydantoinase/oxoprolinase, score 2.8e-38 218491012860 Protein of unknown function (DUF917); Region: DUF917; pfam06032 218491012861 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 218491012862 Na binding site [ion binding]; other site 218491012863 12 probable transmembrane helices predicted for ECA2641 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 145-164, 171-190, 205-227, 239-261, 271-293, 312-331, 341-363, 376-398 and 403-425 218491012864 HMMPfam hit to PF02133, DE Permease for cytosine/purines, uracil, thiamine, allantoin, score 4.7e-06 218491012865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491012866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491012867 LysR substrate binding domain; Region: LysR_substrate; pfam03466 218491012868 dimerization interface [polypeptide binding]; other site 218491012869 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.3e-13 218491012870 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1e-07 218491012871 putative MFS family transporter protein; Provisional; Region: PRK03633 218491012872 Signal peptide predicted for ECA2643 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.407 between residues 23 and 24; signal peptide 218491012873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491012874 putative substrate translocation pore; other site 218491012875 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0035 218491012876 12 probable transmembrane helices predicted for ECA2643 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 131-153, 158-180, 205-227, 237-256, 263-285, 289-308, 328-350 and 354-371 218491012877 seryl-tRNA synthetase; Provisional; Region: PRK05431 218491012878 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 218491012879 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 218491012880 dimer interface [polypeptide binding]; other site 218491012881 active site 218491012882 motif 1; other site 218491012883 motif 2; other site 218491012884 motif 3; other site 218491012885 HMMPfam hit to PF00587, DE tRNA synthetase class II core domain (G, H, P, S and T), score 5.4e-56 218491012886 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491012887 HMMPfam hit to PF02403, DE Seryl-tRNA synthetase N-terminal domain, score 1.6e-13 218491012888 recombination factor protein RarA; Reviewed; Region: PRK13342 218491012889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491012890 Walker A motif; other site 218491012891 ATP binding site [chemical binding]; other site 218491012892 Walker B motif; other site 218491012893 arginine finger; other site 218491012894 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 218491012895 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 9.7e-11 218491012896 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012897 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 218491012898 Signal peptide predicted for ECA2646 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.967 between residues 21 and 22; signal peptide 218491012899 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 218491012900 HMMPfam hit to PF03548, DE Outer membrane lipoprotein carrier protein LolA, score 2e-95 218491012901 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012902 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 218491012903 DNA translocase FtsK; Provisional; Region: PRK10263 218491012904 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 218491012905 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 218491012906 HMMPfam hit to PF01580, DE FtsK/SpoIIIE family, score 9.3e-99 218491012907 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012908 5 probable transmembrane helices predicted for ECA2647 by TMHMM2.0 at aa 22-44, 75-97, 110-132, 137-156 and 163-185 218491012909 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 218491012910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491012911 putative DNA binding site [nucleotide binding]; other site 218491012912 putative Zn2+ binding site [ion binding]; other site 218491012913 AsnC family; Region: AsnC_trans_reg; pfam01037 218491012914 HMMPfam hit to PF01037, DE AsnC family, score 2.2e-55 218491012915 PS00519 Bacterial regulatory proteins, asnC family signature. 218491012916 thioredoxin reductase; Provisional; Region: PRK10262 218491012917 Signal peptide predicted for ECA2649 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.901 between residues 25 and 26; signal peptide 218491012918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491012919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491012920 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 3e-71 218491012921 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 218491012922 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 218491012923 Signal peptide predicted for ECA2650 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.238 between residues 51 and 52; signal peptide 218491012924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491012925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491012926 Walker A/P-loop; other site 218491012927 ATP binding site [chemical binding]; other site 218491012928 Q-loop/lid; other site 218491012929 ABC transporter signature motif; other site 218491012930 Walker B; other site 218491012931 D-loop; other site 218491012932 H-loop/switch region; other site 218491012933 6 probable transmembrane helices predicted for ECA2650 by TMHMM2.0 at aa 23-45, 60-82, 137-159, 163-185, 246-268 and 278-297 218491012934 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 1.1e-37 218491012935 HMMPfam hit to PF00005, DE ABC transporter, score 8.7e-58 218491012936 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012937 PS00211 ABC transporters family signature. 218491012938 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 218491012939 Signal peptide predicted for ECA2651 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.986 between residues 55 and 56; signal peptide 218491012940 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491012941 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 218491012942 Walker A/P-loop; other site 218491012943 ATP binding site [chemical binding]; other site 218491012944 Q-loop/lid; other site 218491012945 ABC transporter signature motif; other site 218491012946 Walker B; other site 218491012947 D-loop; other site 218491012948 H-loop/switch region; other site 218491012949 6 probable transmembrane helices predicted for ECA2651 by TMHMM2.0 at aa 21-43, 47-69, 139-161, 166-188, 251-273 and 283-305 218491012950 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 0.0074 218491012951 HMMPfam hit to PF00005, DE ABC transporter, score 7.6e-60 218491012952 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012953 PS00211 ABC transporters family signature. 218491012954 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 218491012955 HMMPfam hit to PF03588, DE Leucyl/phenylalanyl-tRNA protein transferase, score 1.6e-93 218491012956 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 218491012957 rRNA binding site [nucleotide binding]; other site 218491012958 predicted 30S ribosome binding site; other site 218491012959 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00575, DE S1 RNA binding domain, score 9.4e-10 218491012960 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491012961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491012962 DNA-binding site [nucleotide binding]; DNA binding site 218491012963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491012964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491012965 homodimer interface [polypeptide binding]; other site 218491012966 catalytic residue [active] 218491012967 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 5.3e-12 218491012968 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 43-64, sequence PSARMLAKELGVARGTIEQAYS 218491012969 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 218491012970 Uncharacterized conserved protein [Function unknown]; Region: COG2128 218491012971 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 218491012972 Clp amino terminal domain; Region: Clp_N; pfam02861 218491012973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491012974 Walker A motif; other site 218491012975 ATP binding site [chemical binding]; other site 218491012976 Walker B motif; other site 218491012977 arginine finger; other site 218491012978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491012979 Walker A motif; other site 218491012980 ATP binding site [chemical binding]; other site 218491012981 Walker B motif; other site 218491012982 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218491012983 PS00871 Chaperonins clpA/B signature 2. 218491012984 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012985 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 1.1e-17 218491012986 PS00870 Chaperonins clpA/B signature 1. 218491012987 PS00017 ATP/GTP-binding site motif A (P-loop). 218491012988 HMMPfam hit to PF02861, DE Clp amino terminal domain, score 2.3e-15 218491012989 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 218491012990 HMMPfam hit to PF02617, DE Uncharacterized ACR, COG2127, score 4.4e-41 218491012991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 218491012992 DNA-binding site [nucleotide binding]; DNA binding site 218491012993 RNA-binding motif; other site 218491012994 HMMPfam hit to PF00313, DE 'Cold-shock' DNA-binding domain, score 5.5e-37 218491012995 PS00352 'Cold-shock' DNA-binding domain signature. 218491012996 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 218491012997 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 218491012998 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 218491012999 putative active site [active] 218491013000 putative metal-binding site [ion binding]; other site 218491013001 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013002 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013003 Predicted membrane protein [Function unknown]; Region: COG2431 218491013004 8 probable transmembrane helices predicted for ECA2661 by TMHMM2.0 at aa 24-46, 58-77, 87-109, 130-149, 164-181, 194-216, 231-253 and 301-323 218491013005 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03956, DE Membrane protein of unknown function (DUF340), score 9.7e-81 218491013006 hybrid cluster protein; Provisional; Region: PRK05290 218491013007 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491013008 ACS interaction site; other site 218491013009 CODH interaction site; other site 218491013010 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 218491013011 hybrid metal cluster; other site 218491013012 HMMPfam hit to PF03063, DE Prismane/CO dehydrogenase family, score 9e-275 218491013013 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013014 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 218491013015 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 218491013016 FAD binding pocket [chemical binding]; other site 218491013017 FAD binding motif [chemical binding]; other site 218491013018 phosphate binding motif [ion binding]; other site 218491013019 beta-alpha-beta structure motif; other site 218491013020 NAD binding pocket [chemical binding]; other site 218491013021 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218491013022 catalytic loop [active] 218491013023 iron binding site [ion binding]; other site 218491013024 HMMPfam hit to PF00970, DE Oxidoreductase FAD-binding domain, score 4.1e-09 218491013025 HMMPfam hit to PF00175, DE Oxidoreductase NAD-binding domain, score 0.00011 218491013026 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 3.3e-10 218491013027 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 218491013028 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 218491013029 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 218491013030 putative NAD(P) binding site [chemical binding]; other site 218491013031 putative active site [active] 218491013032 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 218491013033 1 probable transmembrane helix predicted for ECA2664 by TMHMM2.0 at aa 470-492 218491013034 Signal peptide predicted for ECA2665 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.470 between residues 23 and 24; signal peptide 218491013035 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 218491013036 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 218491013037 amidase catalytic site [active] 218491013038 Zn binding residues [ion binding]; other site 218491013039 substrate binding site [chemical binding]; other site 218491013040 HMMPfam hit to PF01510, DE N-acetylmuramoyl-L-alanine amidase, score 8.2e-41 218491013041 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013042 hypothetical protein; Provisional; Region: PRK02877 218491013043 HMMPfam hit to PF01906, DE Domain of unknown function DUF74, score 4.5e-63 218491013044 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 218491013045 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491013046 Walker A/P-loop; other site 218491013047 ATP binding site [chemical binding]; other site 218491013048 Q-loop/lid; other site 218491013049 ABC transporter signature motif; other site 218491013050 Walker B; other site 218491013051 D-loop; other site 218491013052 H-loop/switch region; other site 218491013053 HMMPfam hit to PF00005, DE ABC transporter, score 7.5e-75 218491013054 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013055 PS00211 ABC transporters family signature. 218491013056 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 218491013057 Signal peptide predicted for ECA2668 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 19 and 20; signal peptide 218491013058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491013059 substrate binding pocket [chemical binding]; other site 218491013060 membrane-bound complex binding site; other site 218491013061 hinge residues; other site 218491013062 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 3.3e-87 218491013063 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491013064 Signal peptide predicted for ECA2669 by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.494 between residues 29 and 30; signal peptide 218491013065 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491013066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013067 dimer interface [polypeptide binding]; other site 218491013068 conserved gate region; other site 218491013069 putative PBP binding loops; other site 218491013070 ABC-ATPase subunit interface; other site 218491013071 4 probable transmembrane helices predicted for ECA2669 by TMHMM2.0 at aa 10-32, 60-82, 97-119 and 201-223 218491013072 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.7e-13 218491013073 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013075 dimer interface [polypeptide binding]; other site 218491013076 conserved gate region; other site 218491013077 putative PBP binding loops; other site 218491013078 ABC-ATPase subunit interface; other site 218491013079 5 probable transmembrane helices predicted for ECA2670 by TMHMM2.0 at aa 15-37, 50-72, 82-104, 155-174 and 189-211 218491013080 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.00082 218491013081 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 218491013082 Signal peptide predicted for ECA2671 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 19 and 20; signal peptide 218491013083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491013084 substrate binding pocket [chemical binding]; other site 218491013085 membrane-bound complex binding site; other site 218491013086 hinge residues; other site 218491013087 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 1.5e-85 218491013088 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491013089 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 218491013090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491013091 S-adenosylmethionine binding site [chemical binding]; other site 218491013092 PS01231 RNA methyltransferase trmA family signature 2. 218491013093 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 218491013094 4 probable transmembrane helices predicted for ECA2673 by TMHMM2.0 at aa 13-35, 55-77, 90-112 and 117-139 218491013095 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218491013096 Signal peptide predicted for ECA2674 by SignalP 2.0 HMM (Signal peptide probabilty 0.792) with cleavage site probability 0.558 between residues 45 and 46; signal peptide 218491013097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013098 dimer interface [polypeptide binding]; other site 218491013099 conserved gate region; other site 218491013100 putative PBP binding loops; other site 218491013101 ABC-ATPase subunit interface; other site 218491013102 6 probable transmembrane helices predicted for ECA2674 by TMHMM2.0 at aa 13-35, 69-91, 104-126, 141-163, 184-206 and 242-264 218491013103 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 7.3e-11 218491013104 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013105 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 218491013106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013107 dimer interface [polypeptide binding]; other site 218491013108 conserved gate region; other site 218491013109 putative PBP binding loops; other site 218491013110 ABC-ATPase subunit interface; other site 218491013111 6 probable transmembrane helices predicted for ECA2675 by TMHMM2.0 at aa 34-56, 104-126, 139-161, 189-211, 232-254 and 288-310 218491013112 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.4e-20 218491013113 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013114 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 218491013115 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 218491013116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491013117 Walker A/P-loop; other site 218491013118 ATP binding site [chemical binding]; other site 218491013119 Q-loop/lid; other site 218491013120 ABC transporter signature motif; other site 218491013121 Walker B; other site 218491013122 D-loop; other site 218491013123 H-loop/switch region; other site 218491013124 TOBE domain; Region: TOBE_2; pfam08402 218491013125 HMMPfam hit to PF03459, DE TOBE domain, score 7.7e-06 218491013126 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-69 218491013127 PS00211 ABC transporters family signature. 218491013128 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013129 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 218491013130 Signal peptide predicted for ECA2677 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.953 between residues 26 and 27; signal peptide 218491013131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 218491013132 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 2.5e-18 218491013133 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 218491013134 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 218491013135 RimK-like ATP-grasp domain; Region: RimK; pfam08443 218491013136 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 218491013137 dimer interface [polypeptide binding]; other site 218491013138 FMN binding site [chemical binding]; other site 218491013139 NADPH bind site [chemical binding]; other site 218491013140 HMMPfam hit to PF00881, DE Nitroreductase family, score 2.3e-26 218491013141 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 218491013142 GSH binding site [chemical binding]; other site 218491013143 catalytic residues [active] 218491013144 HMMPfam hit to PF00462, DE Glutaredoxin, score 9.2e-20 218491013145 PS00195 Glutaredoxin active site. 218491013146 Predicted helix-turn-helix motif with score 1111.000, SD 2.97 at aa 43-64, sequence ISKEDLSKTVGKPVETVPQIFL 218491013147 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 218491013148 Signal peptide predicted for ECA2682 by SignalP 2.0 HMM (Signal peptide probabilty 0.809) with cleavage site probability 0.312 between residues 23 and 24; signal peptide 218491013149 4 probable transmembrane helices predicted for ECA2682 by TMHMM2.0 at aa 7-24, 39-56, 63-85 and 95-117 218491013150 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013151 putative transporter; Provisional; Region: PRK04972 218491013152 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 218491013153 TrkA-C domain; Region: TrkA_C; pfam02080 218491013154 TrkA-C domain; Region: TrkA_C; pfam02080 218491013155 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 218491013156 10 probable transmembrane helices predicted for ECA2683 by TMHMM2.0 at aa 7-26, 57-79, 86-104, 109-131, 152-174, 372-394, 401-420, 440-462, 469-491 and 528-550 218491013157 HMMPfam hit to PF02080, DE TrkA-C domain, score 3.3e-14 218491013158 HMMPfam hit to PF02080, DE TrkA-C domain, score 5.1e-10 218491013159 1 probable transmembrane helix predicted for ECA2684 by TMHMM2.0 at aa 38-60 218491013160 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 218491013161 intersubunit interface [polypeptide binding]; other site 218491013162 active site 218491013163 catalytic residue [active] 218491013164 HMMPfam hit to PF01791, DE Deoxyribose-phosphate aldolase, score 1.4e-98 218491013165 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 218491013166 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218491013167 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218491013168 HMMPfam hit to PF00455, DE Bacterial regulatory proteins, deoR family, score 3.5e-63 218491013169 PS00894 Bacterial regulatory proteins, deoR family signature. 218491013170 Predicted helix-turn-helix motif with score 2098.000, SD 6.33 at aa 22-43, sequence LHLKDAAQLLGVSEMTVRRDLN 218491013171 PS00012 Phosphopantetheine attachment site. 218491013172 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 218491013173 Signal peptide predicted for ECA2686 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.973 between residues 29 and 30; signal peptide 218491013174 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 218491013175 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 218491013176 HMMPfam hit to PF00768, DE D-alanyl-D-alanine carboxypeptidase, score 5.8e-144 218491013177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013178 dimer interface [polypeptide binding]; other site 218491013179 conserved gate region; other site 218491013180 ABC-ATPase subunit interface; other site 218491013181 5 probable transmembrane helices predicted for ECA2687 by TMHMM2.0 at aa 20-42, 55-77, 87-109, 150-172 and 192-214 218491013182 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 6.7e-14 218491013183 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013184 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 218491013185 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 218491013186 Walker A/P-loop; other site 218491013187 ATP binding site [chemical binding]; other site 218491013188 Q-loop/lid; other site 218491013189 ABC transporter signature motif; other site 218491013190 Walker B; other site 218491013191 D-loop; other site 218491013192 H-loop/switch region; other site 218491013193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491013194 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 218491013195 HMMPfam hit to PF00005, DE ABC transporter, score 7.2e-70 218491013196 PS00211 ABC transporters family signature. 218491013197 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013198 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 218491013199 Signal peptide predicted for ECA2689 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.475 between residues 27 and 28; signal peptide 218491013200 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 218491013201 HMMPfam hit to PF03180, DE NLPA lipoprotein, score 1.3e-98 218491013202 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218491013203 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 218491013204 putative C-terminal domain interface [polypeptide binding]; other site 218491013205 putative GSH binding site (G-site) [chemical binding]; other site 218491013206 putative dimer interface [polypeptide binding]; other site 218491013207 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 218491013208 putative N-terminal domain interface [polypeptide binding]; other site 218491013209 putative dimer interface [polypeptide binding]; other site 218491013210 putative substrate binding pocket (H-site) [chemical binding]; other site 218491013211 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 3.1e-09 218491013212 Signal peptide predicted for ECA2691 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.993 between residues 40 and 41; signal peptide 218491013213 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 218491013214 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 218491013215 Signal peptide predicted for ECA2692 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.743 between residues 18 and 19; signal peptide 218491013216 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 218491013217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 218491013218 HMMPfam hit to PF01593, DE Flavin containing amine oxidoreductase, score 1.1e-11 218491013219 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491013220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 218491013221 phenazine antibiotic biosynthesis protein 218491013222 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 218491013223 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 218491013224 acyl-activating enzyme (AAE) consensus motif; other site 218491013225 AMP binding site [chemical binding]; other site 218491013226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 218491013227 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 7.7e-05 218491013228 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 7.2e-96 218491013229 PS00455 AMP-binding domain signature. 218491013230 Acyl transferase domain; Region: Acyl_transf_1; cl08282 218491013231 PS00070 Aldehyde dehydrogenases cysteine active site. 218491013232 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 218491013233 NAD(P) binding site [chemical binding]; other site 218491013234 catalytic residues [active] 218491013235 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 218491013236 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 218491013237 PS00455 AMP-binding domain signature. 218491013238 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 218491013239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 218491013240 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 218491013241 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01243, DE Pyridoxamine 5'-phosphate oxidase, score 1.5e-41 218491013242 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 218491013243 HMMPfam hit to PF02567, DE Phenazine biosynthesis-like protein, score 3.7e-68 218491013244 chorismate binding enzyme; Region: Chorismate_bind; cl10555 218491013245 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 218491013246 Glutamine amidotransferase class-I; Region: GATase; pfam00117 218491013247 glutamine binding [chemical binding]; other site 218491013248 catalytic triad [active] 218491013249 HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 1.2e-13 218491013250 HMMPfam hit to PF00425, DE chorismate binding enzyme, score 9.2e-16 218491013251 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 218491013252 Isochorismatase family; Region: Isochorismatase; pfam00857 218491013253 catalytic triad [active] 218491013254 conserved cis-peptide bond; other site 218491013255 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00857, DE Isochorismatase family, score 5.1e-66 218491013256 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 218491013257 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03284, DE Phenazine biosynthesis protein A/B, score 2.4e-77 218491013258 short chain dehydrogenase; Provisional; Region: PRK08263 218491013259 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 218491013260 NADP binding site [chemical binding]; other site 218491013261 active site 218491013262 steroid binding site; other site 218491013263 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.7e-55 218491013264 PS00061 Short-chain dehydrogenases/reductases family signature. 218491013265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491013266 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 218491013267 putative dimer interface [polypeptide binding]; other site 218491013268 HMMPfam hit to PF00903, DE Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 2e-08 218491013269 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 218491013270 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 218491013271 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218491013272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491013273 FeS/SAM binding site; other site 218491013274 HMMPfam hit to PF00919, DE Uncharacterized protein family UPF0004, score 1.8e-39 218491013275 PS01278 Uncharacterized protein family UPF0004 signature. 218491013276 Signal peptide predicted for ECA2709 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 22 and 23; signal peptide 218491013277 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218491013278 putative active site [active] 218491013279 1 probable transmembrane helix predicted for ECA2709 by TMHMM2.0 at aa 7-29 218491013280 Predicted membrane protein [Function unknown]; Region: COG2311 218491013281 hypothetical protein; Provisional; Region: PRK10835 218491013282 10 probable transmembrane helices predicted for ECA2710 by TMHMM2.0 at aa 21-43, 67-89, 96-115, 119-136, 148-167, 211-233, 245-267, 287-309, 322-344 and 349-371 218491013283 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 218491013284 active site 218491013285 HMMPfam hit to PF01227, DE GTP cyclohydrolase I, score 7.8e-56 218491013286 PS00860 GTP cyclohydrolase I signature 2. 218491013287 PS00859 GTP cyclohydrolase I signature 1. 218491013288 Signal peptide predicted for ECA2712 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.384 between residues 39 and 40; signal peptide 218491013289 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491013290 dimer interface [polypeptide binding]; other site 218491013291 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 218491013292 putative CheW interface [polypeptide binding]; other site 218491013293 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 4.1e-109 218491013294 2 probable transmembrane helices predicted for ECA2712 by TMHMM2.0 at aa 10-32 and 193-215 218491013295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491013296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491013297 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 218491013298 putative dimerization interface [polypeptide binding]; other site 218491013299 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.8e-19 218491013300 PS00044 Bacterial regulatory proteins, lysR family signature. 218491013301 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.1e-42 218491013302 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 218491013303 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 218491013304 substrate binding site [chemical binding]; other site 218491013305 catalytic Zn binding site [ion binding]; other site 218491013306 NAD binding site [chemical binding]; other site 218491013307 structural Zn binding site [ion binding]; other site 218491013308 dimer interface [polypeptide binding]; other site 218491013309 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 3.1e-145 218491013310 PS00059 Zinc-containing alcohol dehydrogenases signature. 218491013311 1 probable transmembrane helix predicted for ECA2714 by TMHMM2.0 at aa 192-214 218491013312 S-formylglutathione hydrolase; Region: PLN02442 218491013313 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 218491013314 HMMPfam hit to PF00756, DE esterase, score 3.3e-91 218491013315 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218491013316 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 218491013317 putative C-terminal domain interface [polypeptide binding]; other site 218491013318 putative GSH binding site (G-site) [chemical binding]; other site 218491013319 putative dimer interface [polypeptide binding]; other site 218491013320 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 218491013321 putative N-terminal domain interface [polypeptide binding]; other site 218491013322 putative dimer interface [polypeptide binding]; other site 218491013323 putative substrate binding pocket (H-site) [chemical binding]; other site 218491013324 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 7.4e-08 218491013325 HMMPfam hit to PF00043, DE Glutathione S-transferase, C-terminal domain, score 2.3e-06 218491013326 KTSC domain; Region: KTSC; pfam13619 218491013327 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 218491013328 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 218491013329 putative active site [active] 218491013330 metal binding site [ion binding]; metal-binding site 218491013331 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 6.4e-10 218491013332 PS00913 Iron-containing alcohol dehydrogenases signature 1. 218491013333 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 218491013334 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491013335 Walker A/P-loop; other site 218491013336 ATP binding site [chemical binding]; other site 218491013337 Q-loop/lid; other site 218491013338 ABC transporter signature motif; other site 218491013339 Walker B; other site 218491013340 D-loop; other site 218491013341 H-loop/switch region; other site 218491013342 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491013343 HMMPfam hit to PF00005, DE ABC transporter, score 3.6e-43 218491013344 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013345 HMMPfam hit to PF00005, DE ABC transporter, score 5.4e-21 218491013346 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013347 PS00211 ABC transporters family signature. 218491013348 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491013349 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491013350 TM-ABC transporter signature motif; other site 218491013351 10 probable transmembrane helices predicted for ECA2720 by TMHMM2.0 at aa 20-41, 51-73, 78-100, 105-127, 134-156, 176-198, 232-251, 261-278, 285-302 and 306-328 218491013352 glycerate dehydrogenase; Provisional; Region: PRK06932 218491013353 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 218491013354 putative ligand binding site [chemical binding]; other site 218491013355 putative NAD binding site [chemical binding]; other site 218491013356 catalytic site [active] 218491013357 HMMPfam hit to PF02826, DE D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 4.1e-62 218491013358 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 218491013359 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 218491013360 HMMPfam hit to PF00389, DE D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 1.2e-23 218491013361 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 218491013362 Signal peptide predicted for ECA2722 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.888 between residues 23 and 24; signal peptide 218491013363 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491013364 N-terminal plug; other site 218491013365 ligand-binding site [chemical binding]; other site 218491013366 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 3.5e-19 218491013367 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491013368 PS00430 TonB-dependent receptor proteins signature 1. 218491013369 lysine transporter; Provisional; Region: PRK10836 218491013370 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491013371 HMMPfam hit to PF00324, DE Amino acid permease, score 6.4e-248 218491013372 12 probable transmembrane helices predicted for ECA2723 by TMHMM2.0 at aa 24-46, 56-78, 106-128, 133-155, 162-184, 199-221, 248-270, 294-316, 346-368, 373-395, 419-438 and 448-470 218491013373 PS00218 Amino acid permeases signature. 218491013374 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 218491013375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491013376 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 218491013377 putative dimerization interface [polypeptide binding]; other site 218491013378 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5e-60 218491013379 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.2e-20 218491013380 PS00044 Bacterial regulatory proteins, lysR family signature. 218491013381 Predicted helix-turn-helix motif with score 1120.000, SD 3.00 at aa 18-39, sequence GSTTQASVVLSLSQSAVSAALA 218491013382 Predicted membrane protein [Function unknown]; Region: COG2855 218491013383 9 probable transmembrane helices predicted for ECA2725 by TMHMM2.0 at aa 20-39, 43-65, 100-122, 137-159, 166-188, 238-255, 268-290, 305-323 and 330-352 218491013384 HMMPfam hit to PF03601, DE Conserved hypothetical protein 698, score 1.2e-128 218491013385 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013386 endonuclease IV; Provisional; Region: PRK01060 218491013387 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 218491013388 AP (apurinic/apyrimidinic) site pocket; other site 218491013389 DNA interaction; other site 218491013390 Metal-binding active site; metal-binding site 218491013391 HMMPfam hit to PF01261, DE AP endonuclease family 2, score 1.1e-156 218491013392 PS00729 AP endonucleases family 2 signature 1. 218491013393 PS00730 AP endonucleases family 2 signature 2. 218491013394 PS00731 AP endonucleases family 2 signature 3. 218491013395 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013396 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 218491013397 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 218491013398 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218491013399 active site 218491013400 P-loop; other site 218491013401 phosphorylation site [posttranslational modification] 218491013402 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 218491013403 9 probable transmembrane helices predicted for ECA2727 by TMHMM2.0 at aa 238-260, 273-295, 305-327, 347-369, 379-401, 414-436, 466-483, 490-510 and 530-552 218491013404 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 1.5e-67 218491013405 HMMPfam hit to PF02379, DE PTS system, Fructose specific IIB subunit, score 1.3e-60 218491013406 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 218491013407 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 218491013408 putative substrate binding site [chemical binding]; other site 218491013409 putative ATP binding site [chemical binding]; other site 218491013410 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 9.3e-65 218491013411 PS00584 pfkB family of carbohydrate kinases signature 2. 218491013412 PS00583 pfkB family of carbohydrate kinases signature 1. 218491013413 PS00464 Ribosomal protein L22 signature. 218491013414 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 218491013415 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218491013416 active site 218491013417 phosphorylation site [posttranslational modification] 218491013418 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218491013419 dimerization domain swap beta strand [polypeptide binding]; other site 218491013420 regulatory protein interface [polypeptide binding]; other site 218491013421 active site 218491013422 regulatory phosphorylation site [posttranslational modification]; other site 218491013423 HMMPfam hit to PF00381, DE PTS HPr component phosphorylation site, score 4e-47 218491013424 PS00589 PTS HPR component serine phosphorylation site signature. 218491013425 PS00369 PTS HPR component histidine phosphorylation site signature. 218491013426 HMMPfam hit to PF00359, DE Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 4.2e-67 218491013427 PS00372 PTS EIIA domains phosphorylation site signature 2. 218491013428 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013429 sugar efflux transporter B; Provisional; Region: PRK15011 218491013430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491013431 putative substrate translocation pore; other site 218491013432 12 probable transmembrane helices predicted for ECA2730 by TMHMM2.0 at aa 51-73, 83-105, 117-134, 138-160, 181-203, 208-230, 251-272, 287-309, 316-335, 341-363, 376-395 and 399-421 218491013433 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.007 218491013434 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013435 HMMPfam hit to PF03692, DE Uncharacterised protein family (UPF0153), score 5.4e-40 218491013436 elongation factor P; Provisional; Region: PRK04542 218491013437 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218491013438 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218491013439 RNA binding site [nucleotide binding]; other site 218491013440 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218491013441 RNA binding site [nucleotide binding]; other site 218491013442 HMMPfam hit to PF01132, DE Elongation factor P (EF-P), score 8.1e-96 218491013443 PS01275 Elongation factor P signature. 218491013444 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 218491013445 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 218491013446 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 218491013447 HMMPfam hit to PF02492, DE Cobalamin synthesis protein/P47K, score 4.8e-67 218491013448 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013449 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 218491013450 active site 218491013451 6 probable transmembrane helices predicted for ECA2734 by TMHMM2.0 at aa 7-26, 59-81, 93-115, 146-165, 170-192 and 202-224 218491013452 HMMPfam hit to PF01569, DE PAP2 superfamily, score 3.3e-11 218491013453 Signal peptide predicted for ECA2735 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.459 between residues 34 and 35; signal peptide 218491013454 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 218491013455 NlpC/P60 family; Region: NLPC_P60; pfam00877 218491013456 1 probable transmembrane helix predicted for ECA2735 by TMHMM2.0 at aa 10-32 218491013457 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013458 HMMPfam hit to PF00877, DE NLP/P60 family, score 6.1e-49 218491013459 Signal peptide predicted for ECA2736 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.997 between residues 20 and 21; signal peptide 218491013460 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218491013461 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 218491013462 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 3e-12 218491013463 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 218491013464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013465 dimer interface [polypeptide binding]; other site 218491013466 conserved gate region; other site 218491013467 putative PBP binding loops; other site 218491013468 ABC-ATPase subunit interface; other site 218491013469 6 probable transmembrane helices predicted for ECA2737 by TMHMM2.0 at aa 9-31, 134-156, 173-195, 224-246, 283-305 and 329-348 218491013470 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 8.3e-14 218491013471 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 218491013472 Signal peptide predicted for ECA2738 by SignalP 2.0 HMM (Signal peptide probabilty 0.928) with cleavage site probability 0.742 between residues 42 and 43; signal peptide 218491013473 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218491013474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013475 dimer interface [polypeptide binding]; other site 218491013476 conserved gate region; other site 218491013477 putative PBP binding loops; other site 218491013478 ABC-ATPase subunit interface; other site 218491013479 6 probable transmembrane helices predicted for ECA2738 by TMHMM2.0 at aa 20-42, 139-161, 182-199, 203-222, 257-279 and 306-328 218491013480 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9.4e-16 218491013481 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013482 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 218491013483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491013484 Walker A/P-loop; other site 218491013485 ATP binding site [chemical binding]; other site 218491013486 Q-loop/lid; other site 218491013487 ABC transporter signature motif; other site 218491013488 Walker B; other site 218491013489 D-loop; other site 218491013490 H-loop/switch region; other site 218491013491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491013492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491013493 Walker A/P-loop; other site 218491013494 ATP binding site [chemical binding]; other site 218491013495 Q-loop/lid; other site 218491013496 ABC transporter signature motif; other site 218491013497 Walker B; other site 218491013498 D-loop; other site 218491013499 H-loop/switch region; other site 218491013500 HMMPfam hit to PF00005, DE ABC transporter, score 3.8e-55 218491013501 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013502 PS00211 ABC transporters family signature. 218491013503 HMMPfam hit to PF00005, DE ABC transporter, score 3.9e-60 218491013504 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013505 PS00211 ABC transporters family signature. 218491013506 hypothetical protein; Provisional; Region: PRK11835 218491013507 Signal peptide predicted for ECA2741 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.742 between residues 37 and 38; signal peptide 218491013508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491013509 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 218491013510 putative substrate translocation pore; other site 218491013511 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00079 218491013512 12 probable transmembrane helices predicted for ECA2741 by TMHMM2.0 at aa 7-29, 47-69, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 286-305, 310-332, 345-364 and 368-390 218491013513 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 218491013514 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491013515 RNA binding surface [nucleotide binding]; other site 218491013516 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 218491013517 active site 218491013518 uracil binding [chemical binding]; other site 218491013519 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 2.2e-25 218491013520 PS01149 Rsu family of pseudouridine synthase signature. 218491013521 HMMPfam hit to PF01479, DE S4 domain, score 1.2e-06 218491013522 probable metal-binding protein; Region: matur_matur; TIGR03853 218491013523 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 218491013524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491013525 ATP binding site [chemical binding]; other site 218491013526 putative Mg++ binding site [ion binding]; other site 218491013527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491013528 nucleotide binding region [chemical binding]; other site 218491013529 ATP-binding site [chemical binding]; other site 218491013530 Double zinc ribbon; Region: DZR; pfam12773 218491013531 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 218491013532 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 2.2e-07 218491013533 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 6.9e-10 218491013534 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013535 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 218491013536 5S rRNA interface [nucleotide binding]; other site 218491013537 CTC domain interface [polypeptide binding]; other site 218491013538 L16 interface [polypeptide binding]; other site 218491013539 HMMPfam hit to PF01386, DE Ribosomal L25p family, score 4.9e-36 218491013540 Predicted membrane protein [Function unknown]; Region: COG3503 218491013541 8 probable transmembrane helices predicted for ECA2746 by TMHMM2.0 at aa 52-74, 89-111, 131-153, 196-213, 225-247, 270-292, 299-321 and 345-367 218491013542 Nucleoid-associated protein [General function prediction only]; Region: COG3081 218491013543 nucleoid-associated protein NdpA; Validated; Region: PRK00378 218491013544 hypothetical protein; Provisional; Region: PRK13689 218491013545 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 218491013546 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 218491013547 Signal peptide predicted for ECA2749 by SignalP 2.0 HMM (Signal peptide probabilty 0.636) with cleavage site probability 0.634 between residues 40 and 41; signal peptide 218491013548 Sulfatase; Region: Sulfatase; cl17466 218491013549 PS00430 TonB-dependent receptor proteins signature 1. 218491013550 5 probable transmembrane helices predicted for ECA2749 by TMHMM2.0 at aa 21-43, 58-80, 85-107, 135-157 and 168-190 218491013551 HMMPfam hit to PF00884, DE Sulfatase, score 3.3e-10 218491013552 prophage-like region 218491013553 integrase; Provisional; Region: PRK09692 218491013554 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491013555 active site 218491013556 Int/Topo IB signature motif; other site 218491013557 HMMPfam hit to PF00589, DE Phage integrase family, score 1.3e-32 218491013558 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 218491013559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 218491013561 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 218491013562 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 218491013563 active site 218491013564 metal binding site [ion binding]; metal-binding site 218491013565 interdomain interaction site; other site 218491013566 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 218491013567 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013568 Predicted transcriptional regulator [Transcription]; Region: COG3905 218491013569 HMMPfam hit to PF01402, DE Ribbon-helix-helix protein, copG family, score 0.00016 218491013570 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 218491013571 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 218491013572 active site residue [active] 218491013573 2 probable transmembrane helices predicted for ECA2761 by TMHMM2.0 at aa 119-137 and 141-163 218491013574 HMMPfam hit to PF00581, DE Rhodanese-like domain, score 2e-08 218491013575 PS00215 Mitochondrial energy transfer proteins signature. 218491013576 MATE family multidrug exporter; Provisional; Region: PRK10189 218491013577 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 218491013578 HMMPfam hit to PF01554, DE MatE, score 3.6e-40 218491013579 11 probable transmembrane helices predicted for ECA2762 by TMHMM2.0 at aa 54-76, 91-113, 133-155, 170-192, 199-221, 226-248, 269-291, 315-337, 358-380, 395-417 and 439-461 218491013580 HMMPfam hit to PF01554, DE MatE, score 5.1e-38 218491013581 Signal peptide predicted for ECA2763 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.977 between residues 29 and 30; signal peptide 218491013582 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 218491013583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491013584 putative substrate translocation pore; other site 218491013585 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.019 218491013586 12 probable transmembrane helices predicted for ECA2763 by TMHMM2.0 at aa 12-34, 49-68, 75-97, 101-123, 135-152, 162-184, 205-227, 242-264, 273-295, 299-318, 331-353 and 363-384 218491013587 outer membrane protein X; Provisional; Region: ompX; PRK09408 218491013588 Signal peptide predicted for ECA2764 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24; signal peptide 218491013589 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00695 Enterobacterial virulence outer membrane protein signature 2. 218491013590 PS00694 Enterobacterial virulence outer membrane protein signature 1. 218491013591 threonine and homoserine efflux system; Provisional; Region: PRK10532 218491013592 Signal peptide predicted for ECA2765 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 31 and 32; signal peptide 218491013593 EamA-like transporter family; Region: EamA; pfam00892 218491013594 10 probable transmembrane helices predicted for ECA2765 by TMHMM2.0 at aa 9-31, 37-59, 66-88, 93-115, 122-141, 146-165, 178-197, 202-224, 237-256 and 260-282 218491013595 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 1.8e-17 218491013596 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013597 topology modulation protein; Reviewed; Region: PRK08118 218491013598 AAA domain; Region: AAA_17; pfam13207 218491013599 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013600 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 218491013601 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 218491013602 dimerization interface [polypeptide binding]; other site 218491013603 DPS ferroxidase diiron center [ion binding]; other site 218491013604 ion pore; other site 218491013605 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00210, DE Ferritin-like domain, score 1.2e-18 218491013606 PS00818 Dps protein family signature 1. 218491013607 Signal peptide predicted for ECA2768 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 22 and 23; signal peptide 218491013608 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 218491013609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491013610 substrate binding pocket [chemical binding]; other site 218491013611 membrane-bound complex binding site; other site 218491013612 hinge residues; other site 218491013613 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 1.5e-79 218491013614 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491013615 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491013616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013617 dimer interface [polypeptide binding]; other site 218491013618 conserved gate region; other site 218491013619 putative PBP binding loops; other site 218491013620 ABC-ATPase subunit interface; other site 218491013621 3 probable transmembrane helices predicted for ECA2769 by TMHMM2.0 at aa 20-42, 54-76 and 187-209 218491013622 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 6.2e-14 218491013623 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 218491013624 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491013625 Walker A/P-loop; other site 218491013626 ATP binding site [chemical binding]; other site 218491013627 Q-loop/lid; other site 218491013628 ABC transporter signature motif; other site 218491013629 Walker B; other site 218491013630 D-loop; other site 218491013631 H-loop/switch region; other site 218491013632 HMMPfam hit to PF00005, DE ABC transporter, score 4.8e-72 218491013633 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013634 PS00211 ABC transporters family signature. 218491013635 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 218491013636 active site 218491013637 Zn binding site [ion binding]; other site 218491013638 HMMPfam hit to PF01432, DE Peptidase family M3, score 2.6e-07 218491013639 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013640 glycosyl transferase family protein; Provisional; Region: PRK08136 218491013641 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218491013642 HMMPfam hit to PF00591, DE Glycosyl transferase family, a/b domain, score 4.4e-26 218491013643 HMMPfam hit to PF02885, DE Glycosyl transferase family, helical bundle domain, score 3.8e-18 218491013644 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 218491013645 Gp37 protein; Region: Gp37; pfam09646 218491013646 Signal peptide predicted for ECA2777 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.964 between residues 23 and 24; signal peptide 218491013647 Signal peptide predicted for ECA2778 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.655 between residues 35 and 36; signal peptide 218491013648 Signal peptide predicted for ECA2779 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.675 between residues 21 and 22; signal peptide 218491013649 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491013650 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491013651 catalytic residue [active] 218491013652 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 2.2e-10 218491013653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013654 Signal peptide predicted for ECA2780 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.551 between residues 44 and 45; signal peptide 218491013655 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 218491013656 2 probable transmembrane helices predicted for ECA2780 by TMHMM2.0 at aa 9-28 and 32-51 218491013657 Signal peptide predicted for ECA2781 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.990 between residues 19 and 20; signal peptide 218491013658 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 218491013659 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 2.1e-49 218491013660 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 5.4e-40 218491013661 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218491013662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491013663 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491013664 PS00543 HlyD family secretion proteins signature. 218491013665 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 3.4e-63 218491013666 1 probable transmembrane helix predicted for ECA2782 by TMHMM2.0 at aa 21-43 218491013667 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 218491013668 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 218491013669 Walker A/P-loop; other site 218491013670 ATP binding site [chemical binding]; other site 218491013671 Q-loop/lid; other site 218491013672 ABC transporter signature motif; other site 218491013673 Walker B; other site 218491013674 D-loop; other site 218491013675 H-loop/switch region; other site 218491013676 HMMPfam hit to PF00005, DE ABC transporter, score 1.8e-59 218491013677 PS00211 ABC transporters family signature. 218491013678 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013679 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 0.0006 218491013680 5 probable transmembrane helices predicted for ECA2783 by TMHMM2.0 at aa 21-43, 58-80, 131-153, 157-174 and 255-277 218491013681 Protease inhibitor Inh; Region: Inh; pfam02974 218491013682 HMMPfam hit to PF02974, DE Protease inhibitor Inh, score 1.8e-55 218491013683 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 218491013684 active site 218491013685 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 218491013686 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 0.00039 218491013687 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 0.082 218491013688 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491013689 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013690 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 218491013691 DEAD_2; Region: DEAD_2; pfam06733 218491013692 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 218491013693 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013694 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491013695 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491013696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491013697 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.0091 218491013698 Predicted helix-turn-helix motif with score 1507.000, SD 4.32 at aa 189-210, sequence PSLETLADELNLRRETIVRQFR 218491013699 PS00041 Bacterial regulatory proteins, araC family signature. 218491013700 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 4.6e-05 218491013701 LysE type translocator; Region: LysE; cl00565 218491013702 5 probable transmembrane helices predicted for ECA2788 by TMHMM2.0 at aa 41-63, 75-97, 101-123, 182-204 and 219-236 218491013703 HMMPfam hit to PF01810, DE LysE type translocator, score 3.4e-18 218491013704 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 218491013705 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 218491013706 active site 218491013707 metal binding site [ion binding]; metal-binding site 218491013708 nudix motif; other site 218491013709 HMMPfam hit to PF00293, DE NUDIX domain, score 2.7e-15 218491013710 Predicted helix-turn-helix motif with score 1184.000, SD 3.22 at aa 139-160, sequence QSIDEITQRMMMTPEQFTAWFQ 218491013711 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491013712 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 218491013713 Signal peptide predicted for ECA2790 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 20 and 21; signal peptide 218491013714 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 218491013715 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 218491013716 HMMPfam hit to PF01915, DE Glycosyl hydrolase family 3 C terminal domain, score 9.9e-85 218491013717 HMMPfam hit to PF00933, DE Glycosyl hydrolase family 3 N terminal domain, score 8.4e-104 218491013718 PS00775 Glycosyl hydrolases family 3 active site. 218491013719 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013720 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 218491013721 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 218491013722 putative C-terminal domain interface [polypeptide binding]; other site 218491013723 putative GSH binding site (G-site) [chemical binding]; other site 218491013724 putative dimer interface [polypeptide binding]; other site 218491013725 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 218491013726 putative N-terminal domain interface [polypeptide binding]; other site 218491013727 putative dimer interface [polypeptide binding]; other site 218491013728 putative substrate binding pocket (H-site) [chemical binding]; other site 218491013729 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 4.3e-10 218491013730 Signal peptide predicted for ECA2792 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.740 between residues 27 and 28; signal peptide 218491013731 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 218491013732 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 218491013733 HMMPfam hit to PF00768, DE D-alanyl-D-alanine carboxypeptidase, score 6.9e-103 218491013734 5 probable transmembrane helices predicted for ECA2793 by TMHMM2.0 at aa 5-27, 40-59, 69-91, 104-126 and 136-158 218491013735 Signal peptide predicted for ECA2794 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.988 between residues 22 and 23; signal peptide 218491013736 FMN-binding domain; Region: FMN_bind; cl01081 218491013737 PS00430 TonB-dependent receptor proteins signature 1. 218491013738 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 218491013739 putative active site [active] 218491013740 putative metal binding residues [ion binding]; other site 218491013741 signature motif; other site 218491013742 putative triphosphate binding site [ion binding]; other site 218491013743 dimer interface [polypeptide binding]; other site 218491013744 HMMPfam hit to PF01928, DE CYTH domain, score 6.3e-38 218491013745 Signal peptide predicted for ECA2797 by SignalP 2.0 HMM (Signal peptide probabilty 0.712) with cleavage site probability 0.489 between residues 23 and 24; signal peptide 218491013746 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 218491013747 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 218491013748 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02574, DE Homocysteine S-methyltransferase, score 9.4e-114 218491013749 S-methylmethionine transporter; Provisional; Region: PRK11387 218491013750 HMMPfam hit to PF00324, DE Amino acid permease, score 4.1e-168 218491013751 12 probable transmembrane helices predicted for ECA2798 by TMHMM2.0 at aa 20-42, 52-74, 95-117, 127-146, 159-181, 208-230, 251-273, 288-310, 337-359, 363-385, 408-430 and 435-454 218491013752 PS00218 Amino acid permeases signature. 218491013753 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 218491013754 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218491013755 FMN binding site [chemical binding]; other site 218491013756 active site 218491013757 catalytic residues [active] 218491013758 substrate binding site [chemical binding]; other site 218491013759 HMMPfam hit to PF01207, DE Dihydrouridine synthase (Dus), score 1.1e-120 218491013760 PS01136 Uncharacterized protein family UPF0034 signature. 218491013761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 218491013762 HMMPfam hit to PF02677, DE Uncharacterized BCR, COG1636, score 4.2e-130 218491013763 Signal peptide predicted for ECA2801 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.956 between residues 23 and 24; signal peptide 218491013764 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491013765 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 218491013766 peptide binding site [polypeptide binding]; other site 218491013767 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 3.7e-208 218491013768 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 218491013769 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 218491013770 metal binding site [ion binding]; metal-binding site 218491013771 dimer interface [polypeptide binding]; other site 218491013772 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 1.6e-21 218491013773 RES domain; Region: RES; pfam08808 218491013774 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 218491013775 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 218491013776 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 218491013777 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218491013778 ATP binding site [chemical binding]; other site 218491013779 Mg++ binding site [ion binding]; other site 218491013780 motif III; other site 218491013781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491013782 nucleotide binding region [chemical binding]; other site 218491013783 ATP-binding site [chemical binding]; other site 218491013784 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 2.2e-30 218491013785 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 1.5e-79 218491013786 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491013787 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013788 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218491013789 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491013790 Walker A/P-loop; other site 218491013791 ATP binding site [chemical binding]; other site 218491013792 Q-loop/lid; other site 218491013793 ABC transporter signature motif; other site 218491013794 Walker B; other site 218491013795 D-loop; other site 218491013796 H-loop/switch region; other site 218491013797 HMMPfam hit to PF00005, DE ABC transporter, score 5.2e-50 218491013798 PS00211 ABC transporters family signature. 218491013799 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013800 Signal peptide predicted for ECA2807 by SignalP 2.0 HMM (Signal peptide probabilty 0.876) with cleavage site probability 0.421 between residues 53 and 54; signal peptide 218491013801 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491013802 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491013803 ABC-ATPase subunit interface; other site 218491013804 dimer interface [polypeptide binding]; other site 218491013805 putative PBP binding regions; other site 218491013806 HMMPfam hit to PF01032, DE FecCD transport family, score 7.5e-123 218491013807 10 probable transmembrane helices predicted for ECA2807 by TMHMM2.0 at aa 24-46, 70-92, 105-127, 131-152, 159-181, 185-202, 209-228, 254-276, 288-310 and 320-339 218491013808 Signal peptide predicted for ECA2808 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.691 between residues 32 and 33; signal peptide 218491013809 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491013810 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491013811 ABC-ATPase subunit interface; other site 218491013812 dimer interface [polypeptide binding]; other site 218491013813 putative PBP binding regions; other site 218491013814 9 probable transmembrane helices predicted for ECA2808 by TMHMM2.0 at aa 13-35, 59-76, 89-111, 115-137, 144-166, 186-208, 238-260, 275-297 and 304-326 218491013815 HMMPfam hit to PF01032, DE FecCD transport family, score 6.8e-126 218491013816 Signal peptide predicted for ECA2809 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 32 and 33; signal peptide 218491013817 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 218491013818 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 218491013819 siderophore binding site; other site 218491013820 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 1.2e-62 218491013821 1 probable transmembrane helix predicted for ECA2809 by TMHMM2.0 at aa 16-33 218491013822 Signal peptide predicted for ECA2810 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22; signal peptide 218491013823 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 218491013824 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491013825 N-terminal plug; other site 218491013826 ligand-binding site [chemical binding]; other site 218491013827 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 0.0027 218491013828 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 218491013829 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 218491013830 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01027, DE Uncharacterised protein family UPF0005, score 5.3e-57 218491013831 7 probable transmembrane helices predicted for ECA2812 by TMHMM2.0 at aa 54-73, 83-105, 118-137, 142-161, 168-190, 195-214 and 239-261 218491013832 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 218491013833 MoaE homodimer interface [polypeptide binding]; other site 218491013834 MoaD interaction [polypeptide binding]; other site 218491013835 active site residues [active] 218491013836 HMMPfam hit to PF02391, DE MoaE protein, score 5.1e-54 218491013837 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 218491013838 MoaE interaction surface [polypeptide binding]; other site 218491013839 MoeB interaction surface [polypeptide binding]; other site 218491013840 thiocarboxylated glycine; other site 218491013841 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02597, DE ThiS family, score 1.1e-14 218491013842 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 218491013843 trimer interface [polypeptide binding]; other site 218491013844 dimer interface [polypeptide binding]; other site 218491013845 putative active site [active] 218491013846 HMMPfam hit to PF01967, DE MoaC family, score 6.1e-92 218491013847 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 218491013848 MPT binding site; other site 218491013849 trimer interface [polypeptide binding]; other site 218491013850 HMMPfam hit to PF00994, DE Probable molybdopterin binding domain, score 3.2e-44 218491013851 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 218491013852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491013853 FeS/SAM binding site; other site 218491013854 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 218491013855 HMMPfam hit to PF01444, , score 3.4e-72 218491013856 PS01305 moaA / nifB / pqqE family signature. 218491013857 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 218491013858 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 218491013859 phosphate binding site [ion binding]; other site 218491013860 putative substrate binding pocket [chemical binding]; other site 218491013861 dimer interface [polypeptide binding]; other site 218491013862 HMMPfam hit to PF01933, DE Uncharacterised protein family UPF0052, score 2.7e-103 218491013863 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 218491013864 active site 218491013865 1 probable transmembrane helix predicted for ECA2819 by TMHMM2.0 at aa 10-31 218491013866 excinuclease ABC subunit B; Provisional; Region: PRK05298 218491013867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491013868 ATP binding site [chemical binding]; other site 218491013869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491013870 nucleotide binding region [chemical binding]; other site 218491013871 ATP-binding site [chemical binding]; other site 218491013872 Ultra-violet resistance protein B; Region: UvrB; pfam12344 218491013873 UvrB/uvrC motif; Region: UVR; pfam02151 218491013874 HMMPfam hit to PF02151, DE UvrB/uvrC motif, score 8.2e-09 218491013875 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 1.2e-16 218491013876 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013877 AAA domain; Region: AAA_26; pfam13500 218491013878 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218491013879 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 218491013880 ADP binding site [chemical binding]; other site 218491013881 HMMPfam hit to PF01656, DE Cobyrinic acid a,c-diamide synthase, score 1.1e-45 218491013882 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 218491013883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491013884 S-adenosylmethionine binding site [chemical binding]; other site 218491013885 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 218491013886 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 218491013887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491013888 catalytic residue [active] 218491013889 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 1.6e-44 218491013890 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013891 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 218491013892 biotin synthase; Provisional; Region: PRK15108 218491013893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491013894 FeS/SAM binding site; other site 218491013895 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 218491013896 HMMPfam hit to PF01792, , score 1.5e-199 218491013897 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013898 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 218491013899 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491013900 inhibitor-cofactor binding pocket; inhibition site 218491013901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491013902 catalytic residue [active] 218491013903 HMMPfam hit to PF00202, DE Aminotransferase class-III, score 3.3e-164 218491013904 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491013905 Signal peptide predicted for ECA2827 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.819 between residues 32 and 33; signal peptide 218491013906 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 218491013907 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01670, DE Glycosyl hydrolase family 12, score 2.9e-69 218491013908 hypothetical protein; Provisional; Region: PRK01821 218491013909 HMMPfam hit to PF03788, DE LrgA family, score 1.3e-50 218491013910 4 probable transmembrane helices predicted for ECA2828 by TMHMM2.0 at aa 65-87, 92-114, 121-143 and 147-169 218491013911 hypothetical protein; Provisional; Region: PRK10711 218491013912 Signal peptide predicted for ECA2829 by SignalP 2.0 HMM (Signal peptide probabilty 0.729) with cleavage site probability 0.593 between residues 23 and 24; signal peptide 218491013913 5 probable transmembrane helices predicted for ECA2829 by TMHMM2.0 at aa 2-19, 29-48, 90-112, 132-166 and 201-223 218491013914 cytidine deaminase; Provisional; Region: PRK09027 218491013915 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 218491013916 active site 218491013917 catalytic motif [active] 218491013918 Zn binding site [ion binding]; other site 218491013919 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 218491013920 active site 218491013921 catalytic motif [active] 218491013922 Zn binding site [ion binding]; other site 218491013923 HMMPfam hit to PF00383, DE Cytidine and deoxycytidylate deaminase zinc-binding region, score 2.2e-12 218491013924 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218491013925 malate dehydrogenase; Provisional; Region: PRK13529 218491013926 Malic enzyme, N-terminal domain; Region: malic; pfam00390 218491013927 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 218491013928 NAD(P) binding site [chemical binding]; other site 218491013929 HMMPfam hit to PF00390, DE Malic enzyme, N-terminal domain, score 7.6e-122 218491013930 PS00331 Malic enzymes signature. 218491013931 HMMPfam hit to PF03949, DE Malic enzyme, NAD binding domain, score 5.8e-129 218491013932 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 218491013933 Signal peptide predicted for ECA2832 by SignalP 2.0 HMM (Signal peptide probabilty 0.969) with cleavage site probability 0.712 between residues 55 and 56; signal peptide 218491013934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013935 dimer interface [polypeptide binding]; other site 218491013936 conserved gate region; other site 218491013937 putative PBP binding loops; other site 218491013938 ABC-ATPase subunit interface; other site 218491013939 6 probable transmembrane helices predicted for ECA2832 by TMHMM2.0 at aa 36-58, 105-127, 134-156, 161-183, 223-245 and 265-287 218491013940 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.3e-06 218491013941 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013942 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 218491013943 Signal peptide predicted for ECA2833 by SignalP 2.0 HMM (Signal peptide probabilty 0.891) with cleavage site probability 0.380 between residues 29 and 30; signal peptide 218491013944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491013945 dimer interface [polypeptide binding]; other site 218491013946 conserved gate region; other site 218491013947 putative PBP binding loops; other site 218491013948 ABC-ATPase subunit interface; other site 218491013949 6 probable transmembrane helices predicted for ECA2833 by TMHMM2.0 at aa 9-31, 98-120, 132-154, 169-191, 227-249 and 278-300 218491013950 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0049 218491013951 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491013952 Signal peptide predicted for ECA2834 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 27 and 28; signal peptide 218491013953 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 218491013954 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 218491013955 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 2.2e-67 218491013956 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 218491013957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491013958 Walker A/P-loop; other site 218491013959 ATP binding site [chemical binding]; other site 218491013960 Q-loop/lid; other site 218491013961 ABC transporter signature motif; other site 218491013962 Walker B; other site 218491013963 D-loop; other site 218491013964 H-loop/switch region; other site 218491013965 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218491013966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491013967 Walker A/P-loop; other site 218491013968 ATP binding site [chemical binding]; other site 218491013969 Q-loop/lid; other site 218491013970 ABC transporter signature motif; other site 218491013971 Walker B; other site 218491013972 D-loop; other site 218491013973 H-loop/switch region; other site 218491013974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218491013975 HMMPfam hit to PF00005, DE ABC transporter, score 6.3e-63 218491013976 PS00211 ABC transporters family signature. 218491013977 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013978 HMMPfam hit to PF00005, DE ABC transporter, score 3.9e-51 218491013979 PS00211 ABC transporters family signature. 218491013980 PS00017 ATP/GTP-binding site motif A (P-loop). 218491013981 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 218491013982 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 218491013983 dimer interface [polypeptide binding]; other site 218491013984 putative functional site; other site 218491013985 putative MPT binding site; other site 218491013986 HMMPfam hit to PF03453, DE MoeA N-terminal region (domain I and II), score 1.6e-75 218491013987 HMMPfam hit to PF00994, DE Probable molybdopterin binding domain, score 1.4e-59 218491013988 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 218491013989 HMMPfam hit to PF03454, DE MoeA C-terminal region (domain IV), score 7.5e-21 218491013990 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 218491013991 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 218491013992 ATP binding site [chemical binding]; other site 218491013993 substrate interface [chemical binding]; other site 218491013994 HMMPfam hit to PF00899, DE ThiF family, score 5.2e-54 218491013995 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491013996 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 218491013997 dimer interface [polypeptide binding]; other site 218491013998 FMN binding site [chemical binding]; other site 218491013999 Predicted helix-turn-helix motif with score 1076.000, SD 2.85 at aa 13-34, sequence RSIYAIGDKLPISEDQVTALIT 218491014000 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 218491014001 putative lipid kinase; Reviewed; Region: PRK13057 218491014002 HMMPfam hit to PF00781, DE Diacylglycerol kinase catalytic domain (presumed), score 1.6e-10 218491014003 Signal peptide predicted for ECA2840 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.895 between residues 40 and 41; signal peptide 218491014004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491014005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491014006 metal binding site [ion binding]; metal-binding site 218491014007 active site 218491014008 I-site; other site 218491014009 2 probable transmembrane helices predicted for ECA2840 by TMHMM2.0 at aa 15-34 and 299-321 218491014010 HMMPfam hit to PF00990, DE GGDEF domain, score 3.1e-65 218491014011 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218491014012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491014013 DNA-binding site [nucleotide binding]; DNA binding site 218491014014 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 218491014015 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 2.6e-19 218491014016 PS00043 Bacterial regulatory proteins, gntR family signature. 218491014017 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 218491014018 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 218491014019 tetramer interface [polypeptide binding]; other site 218491014020 active site 218491014021 HMMPfam hit to PF00206, DE Lyase, score 7.1e-46 218491014022 Signal peptide predicted for ECA2843 by SignalP 2.0 HMM (Signal peptide probabilty 0.914) with cleavage site probability 0.450 between residues 45 and 46; signal peptide 218491014023 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218491014024 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218491014025 transmembrane helices; other site 218491014026 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00939, DE Sodium:sulfate symporter transmembrane region, score 3.7e-150 218491014027 11 probable transmembrane helices predicted for ECA2843 by TMHMM2.0 at aa 12-29, 33-52, 59-76, 86-108, 181-203, 218-240, 276-307, 327-346, 359-381, 396-418 and 448-470 218491014028 Predicted helix-turn-helix motif with score 975.000, SD 2.51 at aa 73-94, sequence GTLTEAKALAGFSSGTVWLIFC 218491014029 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 218491014030 HMMPfam hit to PF01679, DE Uncharacterized protein family UPF0057, score 3.2e-21 218491014031 1 probable transmembrane helix predicted for ECA2844 by TMHMM2.0 at aa 26-48 218491014032 PS01309 Uncharacterized protein family UPF0057 signature. 218491014033 Signal peptide predicted for ECA2845 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 26 and 27; signal peptide 218491014034 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 218491014035 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491014036 N-terminal plug; other site 218491014037 ligand-binding site [chemical binding]; other site 218491014038 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 1.9e-24 218491014039 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 218491014040 2 probable transmembrane helices predicted for ECA2846 by TMHMM2.0 at aa 20-42 and 104-123 218491014041 Predicted helix-turn-helix motif with score 1019.000, SD 2.66 at aa 8-29, sequence LSIGYVSELFGVSVKRVAACLA 218491014042 KTSC domain; Region: KTSC; pfam13619 218491014043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491014044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014045 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491014046 putative effector binding pocket; other site 218491014047 dimerization interface [polypeptide binding]; other site 218491014048 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 2.5e-43 218491014049 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 6.3e-15 218491014050 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014051 Predicted helix-turn-helix motif with score 1324.000, SD 3.70 at aa 17-38, sequence GSLTAAANKLDISRAMATRYIA 218491014052 Signal peptide predicted for ECA2849 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.901 between residues 22 and 23; signal peptide 218491014053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218491014054 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491014055 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 3.6e-13 218491014056 genomic island 218491014057 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 218491014058 oligomeric interface; other site 218491014059 putative active site [active] 218491014060 homodimer interface [polypeptide binding]; other site 218491014061 HMMPfam hit to PF01850, DE PIN domain, score 8.4e-24 218491014062 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 218491014063 Methyltransferase domain; Region: Methyltransf_27; pfam13708 218491014064 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 218491014065 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 218491014066 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 218491014067 MPN+ (JAMM) motif; other site 218491014068 Zinc-binding site [ion binding]; other site 218491014069 PS01302 DNA repair protein radC family signature. 218491014070 Signal peptide predicted for ECA2856 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 19 and 20; signal peptide 218491014071 Signal peptide predicted for ECA2857 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.996 between residues 27 and 28; signal peptide 218491014072 YfjP GTPase; Region: YfjP; cd11383 218491014073 G1 box; other site 218491014074 GTP/Mg2+ binding site [chemical binding]; other site 218491014075 Switch I region; other site 218491014076 G2 box; other site 218491014077 Switch II region; other site 218491014078 G3 box; other site 218491014079 G4 box; other site 218491014080 G5 box; other site 218491014081 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014082 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 218491014083 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 218491014084 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 218491014085 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014086 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491014087 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218491014088 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218491014089 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218491014090 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 218491014091 PAAR motif; Region: PAAR_motif; pfam05488 218491014092 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 218491014093 RHS Repeat; Region: RHS_repeat; pfam05593 218491014094 RHS Repeat; Region: RHS_repeat; cl11982 218491014095 RHS Repeat; Region: RHS_repeat; pfam05593 218491014096 RHS Repeat; Region: RHS_repeat; cl11982 218491014097 RHS Repeat; Region: RHS_repeat; cl11982 218491014098 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 218491014099 2 probable transmembrane helices predicted for ECA2869 by TMHMM2.0 at aa 48-70 and 77-99 218491014100 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491014101 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 218491014102 flagellin; Provisional; Region: PRK12806 218491014103 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 218491014104 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 218491014105 HMMPfam hit to PF00669, DE Bacterial flagellin N-terminus, score 5.8e-39 218491014106 HMMPfam hit to PF00700, DE Bacterial flagellin C-terminus, score 2.2e-21 218491014107 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 218491014108 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014109 PS00215 Mitochondrial energy transfer proteins signature. 218491014110 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218491014111 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00190 Cytochrome c family heme-binding site signature. 218491014112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 218491014113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218491014114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491014115 ATP binding site [chemical binding]; other site 218491014116 Mg2+ binding site [ion binding]; other site 218491014117 G-X-G motif; other site 218491014118 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 3.3e-17 218491014119 integrase; Provisional; Region: PRK09692 218491014120 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491014121 active site 218491014122 Int/Topo IB signature motif; other site 218491014123 PS00018 EF-hand calcium-binding domain. 218491014124 HMMPfam hit to PF00589, DE Phage integrase family, score 3.3e-36 218491014125 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 218491014126 Signal peptide predicted for ECA2880 by SignalP 2.0 HMM (Signal peptide probabilty 0.927) with cleavage site probability 0.385 between residues 42 and 43; signal peptide 218491014127 HMMPfam hit to PF01066, DE CDP-alcohol phosphatidyltransferase, score 4.2e-43 218491014128 3 probable transmembrane helices predicted for ECA2880 by TMHMM2.0 at aa 21-43, 73-91 and 148-170 218491014129 PS00379 CDP-alcohol phosphatidyltransferases signature. 218491014130 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 218491014131 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 218491014132 GIY-YIG motif/motif A; other site 218491014133 active site 218491014134 catalytic site [active] 218491014135 putative DNA binding site [nucleotide binding]; other site 218491014136 metal binding site [ion binding]; metal-binding site 218491014137 UvrB/uvrC motif; Region: UVR; pfam02151 218491014138 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 218491014139 HMMPfam hit to PF00633, DE Helix-hairpin-helix motif, score 2.3e-06 218491014140 HMMPfam hit to PF00633, DE Helix-hairpin-helix motif, score 9.2e-06 218491014141 HMMPfam hit to PF02151, DE UvrB/uvrC motif, score 6.8e-11 218491014142 PS00034 'Paired box' domain signature. 218491014143 HMMPfam hit to PF01541, DE Endo/excinuclease amino terminal domain, score 1.9e-31 218491014144 response regulator; Provisional; Region: PRK09483 218491014145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491014146 active site 218491014147 phosphorylation site [posttranslational modification] 218491014148 intermolecular recognition site; other site 218491014149 dimerization interface [polypeptide binding]; other site 218491014150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218491014151 DNA binding residues [nucleotide binding] 218491014152 dimerization interface [polypeptide binding]; other site 218491014153 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 2e-26 218491014154 PS00622 Bacterial regulatory proteins, luxR family signature. 218491014155 Predicted helix-turn-helix motif with score 1026.000, SD 2.68 at aa 164-185, sequence QKVTEISEQLNLSPKTVNSYRY 218491014156 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 8.3e-40 218491014157 PS00070 Aldehyde dehydrogenases cysteine active site. 218491014158 hypothetical protein; Provisional; Region: PRK10613 218491014159 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 218491014160 HMMPfam hit to PF00324, DE Amino acid permease, score 8.2e-192 218491014161 12 probable transmembrane helices predicted for ECA2885 by TMHMM2.0 at aa 30-52, 56-73, 94-116, 136-158, 165-187, 211-233, 254-276, 286-308, 343-365, 369-391, 414-436 and 441-460 218491014162 PS00218 Amino acid permeases signature. 218491014163 anti-RssB factor; Provisional; Region: PRK10244 218491014164 1 probable transmembrane helix predicted for ECA2887 by TMHMM2.0 at aa 15-34 218491014165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014166 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.9e-26 218491014167 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014168 Predicted helix-turn-helix motif with score 1700.000, SD 4.98 at aa 16-37, sequence GSLTQAAELLHIAQPALSQQVA 218491014169 genomic island 218491014170 integrase; Provisional; Region: PRK09692 218491014171 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491014172 active site 218491014173 Int/Topo IB signature motif; other site 218491014174 HMMPfam hit to PF00589, DE Phage integrase family, score 6.7e-32 218491014175 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014176 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 218491014177 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 218491014178 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 218491014179 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 218491014180 HMMPfam hit to PF00816, DE H-NS histone family, score 1.5e-67 218491014181 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014182 Conjugal transfer protein TraD; Region: TraD; pfam06412 218491014183 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 218491014184 MobA/MobL family; Region: MobA_MobL; pfam03389 218491014185 HMMPfam hit to PF03389, DE MobA/MobL family, score 4.8e-43 218491014186 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 218491014187 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 218491014188 5 probable transmembrane helices predicted for ECA2903 by TMHMM2.0 at aa 4-26, 38-55, 65-87, 99-116 and 131-150 218491014189 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014190 1 probable transmembrane helix predicted for ECA2905 by TMHMM2.0 at aa 15-37 218491014191 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 218491014192 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218491014193 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 81-113, sequence LEYMEFGNLINLSQSSLCKALNIASGNMSNIFK 218491014194 Predicted helix-turn-helix motif with score 1224.000, SD 3.36 at aa 81-102, sequence LEYMEFGNLINLSQSSLCKALN 218491014195 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 92-113, sequence LSQSSLCKALNIASGNMSNIFK 218491014196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491014197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491014198 non-specific DNA binding site [nucleotide binding]; other site 218491014199 salt bridge; other site 218491014200 sequence-specific DNA binding site [nucleotide binding]; other site 218491014201 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 218491014202 HMMPfam hit to PF01381, DE Helix-turn-helix, score 1.6e-07 218491014203 Predicted helix-turn-helix motif with score 2084.000, SD 6.28 at aa 16-37, sequence LTQRALAEAAGLTSKTISNYEK 218491014204 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 218491014205 PS00018 EF-hand calcium-binding domain. 218491014206 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 218491014207 1 probable transmembrane helix predicted for ECA2920 by TMHMM2.0 at aa 13-35 218491014208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491014209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014210 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218491014211 putative effector binding pocket; other site 218491014212 putative dimerization interface [polypeptide binding]; other site 218491014213 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.7e-40 218491014214 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 6.3e-22 218491014215 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014216 Predicted helix-turn-helix motif with score 1834.000, SD 5.43 at aa 19-40, sequence RSFTKAALRLGMAQSALSQIVR 218491014217 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491014218 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 218491014219 putative active site [active] 218491014220 putative FMN binding site [chemical binding]; other site 218491014221 putative substrate binding site [chemical binding]; other site 218491014222 putative catalytic residue [active] 218491014223 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 1.6e-82 218491014224 Signal peptide predicted for ECA2924 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.818 between residues 22 and 23; signal peptide 218491014225 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014226 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 218491014227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491014228 NAD(P) binding site [chemical binding]; other site 218491014229 active site 218491014230 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2e-49 218491014231 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 218491014232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491014233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491014234 putative substrate translocation pore; other site 218491014235 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0014 218491014236 12 probable transmembrane helices predicted for ECA2927 by TMHMM2.0 at aa 26-48, 63-85, 92-111, 116-138, 151-173, 178-200, 230-252, 262-284, 291-313, 328-350, 355-377 and 381-403 218491014237 PS00216 Sugar transport proteins signature 1. 218491014238 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 218491014239 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218491014240 dimer interface [polypeptide binding]; other site 218491014241 active site 218491014242 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 5.3e-60 218491014243 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 9.9e-61 218491014244 PS00606 Beta-ketoacyl synthases active site. 218491014245 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 218491014246 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 3.6e-66 218491014247 12 probable transmembrane helices predicted for ECA2929 by TMHMM2.0 at aa 13-35, 343-360, 362-381, 391-410, 430-452, 467-489, 523-545, 860-879, 886-908, 912-934, 964-986 and 991-1013 218491014248 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491014249 Signal peptide predicted for ECA2930 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.509 between residues 20 and 21; signal peptide 218491014250 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 218491014251 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491014252 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 0.0021 218491014253 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491014255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491014256 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 6.2e-09 218491014257 Predicted helix-turn-helix motif with score 1304.000, SD 3.63 at aa 38-59, sequence TTVSDLAKAIGFSKAYIYKFFD 218491014258 Signal peptide predicted for ECA2932 by SignalP 2.0 HMM (Signal peptide probabilty 0.860) with cleavage site probability 0.480 between residues 22 and 23; signal peptide 218491014259 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 218491014260 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014261 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 2.5e-24 218491014262 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 3.3e-23 218491014263 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 218491014264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491014265 NAD(P) binding site [chemical binding]; other site 218491014266 active site 218491014267 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2.1e-35 218491014268 PS00061 Short-chain dehydrogenases/reductases family signature. 218491014269 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491014270 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491014271 HMMPfam hit to PF01638, DE Transcriptional regulator, score 1e-32 218491014272 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 218491014273 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 218491014274 nitrogen fixation cluster 218491014275 NifQ; Region: NifQ; pfam04891 218491014276 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 218491014277 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 218491014278 HMMPfam hit to PF02579, DE Dinitrogenase iron-molybdenum cofactor, score 9.2e-33 218491014279 HMMPfam hit to PF01444, , score 2.7e-63 218491014280 PS01305 moaA / nifB / pqqE family signature. 218491014281 Nif-specific regulatory protein; Region: nifA; TIGR01817 218491014282 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218491014283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491014284 Walker A motif; other site 218491014285 ATP binding site [chemical binding]; other site 218491014286 Walker B motif; other site 218491014287 arginine finger; other site 218491014288 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 218491014289 HMMPfam hit to PF02954, DE Bacterial regulatory protein, Fis family, score 3.3e-12 218491014290 Predicted helix-turn-helix motif with score 1832.000, SD 5.43 at aa 494-515, sequence WVQAKAARLLGMTPRQVAYRIQ 218491014291 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491014292 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 2e-155 218491014293 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491014294 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491014295 HMMPfam hit to PF01590, DE GAF domain, score 5.8e-21 218491014296 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 218491014297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491014298 putative active site [active] 218491014299 heme pocket [chemical binding]; other site 218491014300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491014301 ATP binding site [chemical binding]; other site 218491014302 G-X-G motif; other site 218491014303 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 0.11 218491014304 HMMPfam hit to PF00785, DE PAC motif, score 3.1e-09 218491014305 HMMPfam hit to PF00989, DE PAS domain, score 5e-10 218491014306 flavodoxin FldA; Validated; Region: PRK09267 218491014307 HMMPfam hit to PF00258, DE Flavodoxin, score 2.8e-41 218491014308 PS00201 Flavodoxin signature. 218491014309 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 218491014310 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 218491014311 HMMPfam hit to PF00639, DE PPIC-type PPIASE domain, score 1.6e-34 218491014312 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 218491014313 NifZ domain; Region: NifZ; pfam04319 218491014314 Nitrogen fixation protein NifW; Region: NifW; cl03935 218491014315 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 218491014316 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 218491014317 active site 218491014318 catalytic residues [active] 218491014319 metal binding site [ion binding]; metal-binding site 218491014320 HMMPfam hit to PF00682, DE HMGL-like, score 2.9e-111 218491014321 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 218491014322 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 218491014323 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 218491014324 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 218491014325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491014326 catalytic residue [active] 218491014327 HMMPfam hit to PF00266, DE Aminotransferase class-V, score 2.5e-164 218491014328 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218491014329 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 218491014330 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 218491014331 trimerization site [polypeptide binding]; other site 218491014332 active site 218491014333 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218491014334 NifU-like domain; Region: NifU; pfam01106 218491014335 HMMPfam hit to PF01106, DE NifU-like domain, score 7.4e-34 218491014336 PS00190 Cytochrome c family heme-binding site signature. 218491014337 HMMPfam hit to PF01592, DE NifU-like N terminal domain, score 7.2e-81 218491014338 Signal peptide predicted for ECA2947 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.990 between residues 23 and 24; signal peptide 218491014339 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 218491014340 HMMPfam hit to PF02579, DE Dinitrogenase iron-molybdenum cofactor, score 6.8e-28 218491014341 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 218491014342 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 218491014343 HMMPfam hit to PF00148, DE Nitrogenase component 1 type Oxidoreductase, score 4.9e-124 218491014344 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014345 PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. 218491014346 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 218491014347 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 218491014348 HMMPfam hit to PF00148, DE Nitrogenase component 1 type Oxidoreductase, score 1.1e-177 218491014349 PS00090 Nitrogenases component 1 alpha and beta subunits signature 2. 218491014350 PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. 218491014351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491014352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491014353 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 5.8e-05 218491014354 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491014355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491014356 putative substrate translocation pore; other site 218491014357 12 probable transmembrane helices predicted for ECA2951 by TMHMM2.0 at aa 88-110, 125-147, 154-173, 183-202, 214-236, 246-265, 278-300, 320-342, 349-371, 375-397, 409-431 and 436-455 218491014358 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0023 218491014359 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 218491014360 HMMPfam hit to PF02579, DE Dinitrogenase iron-molybdenum cofactor, score 2.8e-25 218491014361 NifT/FixU protein; Region: NifT; pfam06988 218491014362 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 218491014363 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 218491014364 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 218491014365 MoFe protein beta/alpha subunit interactions; other site 218491014366 Beta subunit P cluster binding residues; other site 218491014367 MoFe protein beta subunit/Fe protein contacts; other site 218491014368 MoFe protein dimer/ dimer interactions; other site 218491014369 HMMPfam hit to PF00148, DE Nitrogenase component 1 type Oxidoreductase, score 1.1e-204 218491014370 PS00090 Nitrogenases component 1 alpha and beta subunits signature 2. 218491014371 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014372 PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. 218491014373 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 218491014374 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 218491014375 MoFe protein alpha/beta subunit interactions; other site 218491014376 Alpha subunit P cluster binding residues; other site 218491014377 FeMoco binding residues [chemical binding]; other site 218491014378 MoFe protein alpha subunit/Fe protein contacts; other site 218491014379 MoFe protein dimer/ dimer interactions; other site 218491014380 HMMPfam hit to PF00148, DE Nitrogenase component 1 type Oxidoreductase, score 5.8e-217 218491014381 PS00090 Nitrogenases component 1 alpha and beta subunits signature 2. 218491014382 PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. 218491014383 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 218491014384 nitrogenase iron protein; Region: nifH; TIGR01287 218491014385 Nucleotide-binding sites [chemical binding]; other site 218491014386 Walker A motif; other site 218491014387 Switch I region of nucleotide binding site; other site 218491014388 Fe4S4 binding sites [ion binding]; other site 218491014389 Switch II region of nucleotide binding site; other site 218491014390 HMMPfam hit to PF00142, DE 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family, score 4.2e-203 218491014391 PS00692 NifH/frxC family signature 2. 218491014392 PS00746 NifH/frxC family signature 1. 218491014393 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014394 Signal peptide predicted for ECA2957 by SignalP 2.0 HMM (Signal peptide probabilty 0.695) with cleavage site probability 0.457 between residues 25 and 26; signal peptide 218491014395 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 218491014396 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 218491014397 dimer interface [polypeptide binding]; other site 218491014398 PYR/PP interface [polypeptide binding]; other site 218491014399 TPP binding site [chemical binding]; other site 218491014400 substrate binding site [chemical binding]; other site 218491014401 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 218491014402 Domain of unknown function; Region: EKR; smart00890 218491014403 4Fe-4S binding domain; Region: Fer4_6; pfam12837 218491014404 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 218491014405 TPP-binding site [chemical binding]; other site 218491014406 dimer interface [polypeptide binding]; other site 218491014407 HMMPfam hit to PF01855, DE Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 5.3e-118 218491014408 HMMPfam hit to PF01558, DE Pyruvate ferredoxin/flavodoxin oxidoreductase, score 6.4e-79 218491014409 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00023 218491014410 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491014411 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.0027 218491014412 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491014413 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 218491014414 high affinity sulphate transporter 1; Region: sulP; TIGR00815 218491014415 Sulfate transporter family; Region: Sulfate_transp; pfam00916 218491014416 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 218491014417 11 probable transmembrane helices predicted for ECA2958 by TMHMM2.0 at aa 32-54, 59-81, 101-123, 136-155, 160-179, 186-203, 231-253, 273-295, 305-324, 331-353 and 368-397 218491014418 HMMPfam hit to PF00916, DE Sulfate transporter family, score 1.4e-73 218491014419 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01740, DE STAS domain, score 0.57 218491014420 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 218491014421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491014422 Walker A/P-loop; other site 218491014423 ATP binding site [chemical binding]; other site 218491014424 Q-loop/lid; other site 218491014425 ABC transporter signature motif; other site 218491014426 Walker B; other site 218491014427 D-loop; other site 218491014428 H-loop/switch region; other site 218491014429 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491014430 HMMPfam hit to PF00005, DE ABC transporter, score 1.1e-62 218491014431 PS00211 ABC transporters family signature. 218491014432 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014433 Signal peptide predicted for ECA2961 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.453 between residues 30 and 31; signal peptide 218491014434 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 218491014435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014436 dimer interface [polypeptide binding]; other site 218491014437 conserved gate region; other site 218491014438 putative PBP binding loops; other site 218491014439 ABC-ATPase subunit interface; other site 218491014440 6 probable transmembrane helices predicted for ECA2961 by TMHMM2.0 at aa 9-31, 76-98, 111-130, 135-157, 178-200 and 232-254 218491014441 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2e-08 218491014442 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491014443 Signal peptide predicted for ECA2962 by SignalP 2.0 HMM (Signal peptide probabilty 0.888) with cleavage site probability 0.475 between residues 29 and 30; signal peptide 218491014444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014445 dimer interface [polypeptide binding]; other site 218491014446 conserved gate region; other site 218491014447 putative PBP binding loops; other site 218491014448 ABC-ATPase subunit interface; other site 218491014449 6 probable transmembrane helices predicted for ECA2962 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 176-195, 235-257 and 281-300 218491014450 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0071 218491014451 PS00211 ABC transporters family signature. 218491014452 Signal peptide predicted for ECA2963 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 24 and 25; signal peptide 218491014453 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491014454 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 218491014455 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 7.5e-16 218491014456 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 218491014457 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 218491014458 metal binding site [ion binding]; metal-binding site 218491014459 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 4e-14 218491014460 galactonate dehydratase; Provisional; Region: PRK14017 218491014461 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 218491014462 active site pocket [active] 218491014463 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 1.1e-24 218491014464 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 218491014465 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 1e-23 218491014466 Signal peptide predicted for ECA2966 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.981 between residues 23 and 24; signal peptide 218491014467 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491014468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491014469 substrate binding pocket [chemical binding]; other site 218491014470 membrane-bound complex binding site; other site 218491014471 hinge residues; other site 218491014472 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 4.1e-32 218491014473 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 218491014474 HMMPfam hit to PF03972, DE MmgE/PrpD family, score 4.2e-42 218491014475 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491014476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014477 dimer interface [polypeptide binding]; other site 218491014478 conserved gate region; other site 218491014479 putative PBP binding loops; other site 218491014480 ABC-ATPase subunit interface; other site 218491014481 3 probable transmembrane helices predicted for ECA2968 by TMHMM2.0 at aa 20-42, 74-96 and 191-213 218491014482 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 8.7e-10 218491014483 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491014484 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491014485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014486 dimer interface [polypeptide binding]; other site 218491014487 conserved gate region; other site 218491014488 putative PBP binding loops; other site 218491014489 ABC-ATPase subunit interface; other site 218491014490 3 probable transmembrane helices predicted for ECA2969 by TMHMM2.0 at aa 27-49, 73-95 and 189-211 218491014491 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.6e-15 218491014492 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491014493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491014494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491014495 Walker A/P-loop; other site 218491014496 ATP binding site [chemical binding]; other site 218491014497 Q-loop/lid; other site 218491014498 ABC transporter signature motif; other site 218491014499 Walker B; other site 218491014500 D-loop; other site 218491014501 H-loop/switch region; other site 218491014502 HMMPfam hit to PF00005, DE ABC transporter, score 6.7e-67 218491014503 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014504 PS00211 ABC transporters family signature. 218491014505 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 218491014506 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 218491014507 homodimer interface [polypeptide binding]; other site 218491014508 substrate-cofactor binding pocket; other site 218491014509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491014510 HMMPfam hit to PF01063, DE Aminotransferase class IV, score 1.2e-39 218491014511 PS00148 Arginase family signature 2. 218491014512 SnoaL-like domain; Region: SnoaL_2; pfam12680 218491014513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 218491014514 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 218491014515 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 4.8e-30 218491014516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491014517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491014519 dimerization interface [polypeptide binding]; other site 218491014520 PS00228 Tubulin-beta mRNA autoregulation signal. 218491014521 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 6.5e-15 218491014522 Predicted helix-turn-helix motif with score 2044.000, SD 6.15 at aa 21-42, sequence SSLTKTAIKLKVSQSTVSRRIG 218491014523 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014524 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 4.2e-18 218491014525 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 218491014526 nudix motif; other site 218491014527 HMMPfam hit to PF00293, DE NUDIX domain, score 2.5e-21 218491014528 PS00893 mutT domain signature. 218491014529 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 218491014530 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 218491014531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491014533 dimerization interface [polypeptide binding]; other site 218491014534 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.9e-20 218491014535 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.7e-21 218491014536 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014537 Predicted helix-turn-helix motif with score 1469.000, SD 4.19 at aa 21-42, sequence DSFARAAEELSLTEGAISRQIA 218491014538 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 218491014539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218491014540 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 4e-10 218491014541 Signal peptide predicted for ECA2981 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 24 and 25; signal peptide 218491014542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 218491014543 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 218491014544 HMMPfam hit to PF00893, DE Small Multidrug Resistance protein, score 3.7e-47 218491014545 3 probable transmembrane helices predicted for ECA2982 by TMHMM2.0 at aa 30-52, 56-78 and 85-104 218491014546 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491014547 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 218491014548 active site 218491014549 FMN binding site [chemical binding]; other site 218491014550 substrate binding site [chemical binding]; other site 218491014551 homotetramer interface [polypeptide binding]; other site 218491014552 catalytic residue [active] 218491014553 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 1.3e-70 218491014554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491014555 dimerization interface [polypeptide binding]; other site 218491014556 putative DNA binding site [nucleotide binding]; other site 218491014557 putative Zn2+ binding site [ion binding]; other site 218491014558 HMMPfam hit to PF01022, DE Bacterial regulatory protein, arsR family, score 4.3e-06 218491014559 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 218491014560 Cupin domain; Region: Cupin_2; cl17218 218491014561 HMMPfam hit to PF03079, DE ARD/ARD' family, score 2.5e-31 218491014562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 218491014563 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 218491014564 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 218491014565 nitrate and nitrite assimilation proteins 218491014566 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 218491014567 active site 218491014568 SAM binding site [chemical binding]; other site 218491014569 homodimer interface [polypeptide binding]; other site 218491014570 HMMPfam hit to PF00590, DE Tetrapyrrole (Corrin/Porphyrin) Methylases, score 1.9e-81 218491014571 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 218491014572 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 218491014573 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 218491014574 [4Fe-4S] binding site [ion binding]; other site 218491014575 molybdopterin cofactor binding site; other site 218491014576 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 218491014577 molybdopterin cofactor binding site; other site 218491014578 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218491014579 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 218491014580 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014581 HMMPfam hit to PF01568, DE Molydopterin dinucleotide binding domain, score 5.1e-19 218491014582 HMMPfam hit to PF00384, DE Molybdopterin oxidoreductase, score 1.8e-172 218491014583 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 218491014584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 218491014585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491014586 nitrite reductase subunit NirD; Provisional; Region: PRK14989 218491014587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491014588 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218491014589 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 218491014590 HMMPfam hit to PF01077, DE Nitrite and sulphite reductase 4Fe-4S domain, score 9.6e-30 218491014591 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 218491014592 HMMPfam hit to PF03460, DE Nitrite/Sulfite reductase ferredoxin-like half domain, score 4e-23 218491014593 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 3.3e-65 218491014594 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 3.3e-61 218491014595 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491014596 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491014597 Walker A/P-loop; other site 218491014598 ATP binding site [chemical binding]; other site 218491014599 Q-loop/lid; other site 218491014600 ABC transporter signature motif; other site 218491014601 Walker B; other site 218491014602 D-loop; other site 218491014603 H-loop/switch region; other site 218491014604 HMMPfam hit to PF00005, DE ABC transporter, score 1.1e-67 218491014605 PS00211 ABC transporters family signature. 218491014606 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014607 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491014608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014609 dimer interface [polypeptide binding]; other site 218491014610 conserved gate region; other site 218491014611 putative PBP binding loops; other site 218491014612 ABC-ATPase subunit interface; other site 218491014613 4 probable transmembrane helices predicted for ECA2993 by TMHMM2.0 at aa 28-50, 97-119, 217-239 and 249-271 218491014614 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9.3e-16 218491014615 Signal peptide predicted for ECA2994 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 39 and 40; signal peptide 218491014616 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 218491014617 NMT1-like family; Region: NMT1_2; pfam13379 218491014618 Nitrate and nitrite sensing; Region: NIT; pfam08376 218491014619 ANTAR domain; Region: ANTAR; pfam03861 218491014620 HMMPfam hit to PF03861, DE ANTAR domain, score 5.6e-19 218491014621 Phage Tail Collar Domain; Region: Collar; pfam07484 218491014622 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 218491014623 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 218491014624 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 218491014625 HMMPfam hit to PF01654, DE Bacterial Cytochrome Ubiquinol Oxidase, score 4.2e-301 218491014626 9 probable transmembrane helices predicted for ECA2998 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 129-151, 185-207, 219-238, 387-409, 421-443 and 471-493 218491014627 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218491014628 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 218491014629 HMMPfam hit to PF02322, DE Cytochrome oxidase subunit II, score 9e-197 218491014630 8 probable transmembrane helices predicted for ECA2999 by TMHMM2.0 at aa 7-24, 77-99, 119-141, 161-183, 204-226, 260-282, 289-311 and 338-360 218491014631 Domain of unknown function (DUF202); Region: DUF202; cl09954 218491014632 HMMPfam hit to PF02656, DE Domain of unknown function DUF, score 2e-28 218491014633 3 probable transmembrane helices predicted for ECA3000 by TMHMM2.0 at aa 73-95, 99-121 and 141-163 218491014634 Domain of unknown function (DUF202); Region: DUF202; pfam02656 218491014635 3 probable transmembrane helices predicted for ECA3001 by TMHMM2.0 at aa 21-38, 42-64 and 84-106 218491014636 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 218491014637 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 218491014638 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491014639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491014640 DNA-binding site [nucleotide binding]; DNA binding site 218491014641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491014642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491014643 homodimer interface [polypeptide binding]; other site 218491014644 catalytic residue [active] 218491014645 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 1.9e-07 218491014646 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 9.4e-07 218491014647 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 218491014648 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 218491014649 catalytic triad [active] 218491014650 HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 7.1e-07 218491014651 PS00442 Glutamine amidotransferases class-I active site. 218491014652 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 218491014653 2 probable transmembrane helices predicted for ECA3006 by TMHMM2.0 at aa 39-61 and 65-82 218491014654 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 218491014655 NADH(P)-binding; Region: NAD_binding_10; pfam13460 218491014656 NAD(P) binding site [chemical binding]; other site 218491014657 putative active site [active] 218491014658 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 218491014659 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 218491014660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491014661 FeS/SAM binding site; other site 218491014662 HMMPfam hit to PF02473, , score 1.1e-12 218491014663 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 218491014664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491014665 Walker A/P-loop; other site 218491014666 ATP binding site [chemical binding]; other site 218491014667 Q-loop/lid; other site 218491014668 ABC transporter signature motif; other site 218491014669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491014670 Walker B; other site 218491014671 D-loop; other site 218491014672 H-loop/switch region; other site 218491014673 ABC transporter; Region: ABC_tran_2; pfam12848 218491014674 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491014675 HMMPfam hit to PF00005, DE ABC transporter, score 8.3e-42 218491014676 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014677 HMMPfam hit to PF00005, DE ABC transporter, score 4.5e-37 218491014678 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014679 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 218491014680 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 218491014681 HMMPfam hit to PF02567, DE Phenazine biosynthesis-like protein, score 8.2e-62 218491014682 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491014683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 218491014684 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218491014685 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.6e-06 218491014686 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 218491014687 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491014688 active site turn [active] 218491014689 phosphorylation site [posttranslational modification] 218491014690 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491014691 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 9.9e-15 218491014692 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491014693 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 1.9e-15 218491014694 10 probable transmembrane helices predicted for ECA3013 by TMHMM2.0 at aa 136-158, 178-200, 207-229, 249-271, 278-300, 318-340, 361-383, 393-415, 428-450 and 460-482 218491014695 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 218491014696 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 218491014697 Ca binding site [ion binding]; other site 218491014698 active site 218491014699 catalytic site [active] 218491014700 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 218491014701 HMMPfam hit to PF00128, DE Alpha amylase, catalytic domain, score 1.8e-133 218491014702 Predicted helix-turn-helix motif with score 1028.000, SD 2.69 at aa 93-114, sequence RRIRIVMDMVFNHTSTQHHWFQ 218491014703 hypothetical protein; Provisional; Region: PRK10404 218491014704 1 probable transmembrane helix predicted for ECA3015 by TMHMM2.0 at aa 82-101 218491014705 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 218491014706 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218491014707 14 probable transmembrane helices predicted for ECA3016 by TMHMM2.0 at aa 5-27, 34-56, 71-93, 105-120, 125-147, 159-181, 201-223, 236-258, 268-290, 297-316, 326-348, 370-392, 407-426 and 447-469 218491014708 HMMPfam hit to PF00361, DE NADH-Ubiquinone/plastoquinone (complex I), various chains, score 4.9e-85 218491014709 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 218491014710 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218491014711 12 probable transmembrane helices predicted for ECA3017 by TMHMM2.0 at aa 5-20, 27-49, 85-107, 120-142, 174-196, 217-239, 284-306, 313-331, 341-363, 376-398, 418-440 and 461-483 218491014712 HMMPfam hit to PF00361, DE NADH-Ubiquinone/plastoquinone (complex I), various chains, score 2e-78 218491014713 Signal peptide predicted for ECA3018 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.948 between residues 26 and 27; signal peptide 218491014714 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 218491014715 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 218491014716 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 218491014717 14 probable transmembrane helices predicted for ECA3018 by TMHMM2.0 at aa 4-21, 28-50, 88-110, 117-136, 140-162, 175-192, 248-270, 283-305, 336-358, 379-401, 416-438, 459-481, 496-518 and 597-615 218491014718 HMMPfam hit to PF00361, DE NADH-Ubiquinone/plastoquinone (complex I), various chains, score 3.5e-119 218491014719 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014720 HMMPfam hit to PF00662, DE NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus, score 1.9e-24 218491014721 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 218491014722 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00420, DE NADH-ubiquinone/plastoquinone oxidoreductase chain 4L, score 3.1e-22 218491014723 3 probable transmembrane helices predicted for ECA3019 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 218491014724 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 218491014725 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 218491014726 HMMPfam hit to PF00499, DE NADH-ubiquinone/plastoquinone oxidoreductase chain 6, score 2.2e-10 218491014727 5 probable transmembrane helices predicted for ECA3020 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 218491014728 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 218491014729 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491014730 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 7.7e-07 218491014731 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491014732 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.001 218491014733 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491014734 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 218491014735 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 218491014736 8 probable transmembrane helices predicted for ECA3022 by TMHMM2.0 at aa 10-32, 81-103, 113-135, 155-174, 189-206, 234-256, 266-288 and 300-322 218491014737 HMMPfam hit to PF00146, DE NADH dehydrogenase, score 7.8e-168 218491014738 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 218491014739 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 218491014740 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 218491014741 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218491014742 catalytic loop [active] 218491014743 iron binding site [ion binding]; other site 218491014744 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 218491014745 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 218491014746 [4Fe-4S] binding site [ion binding]; other site 218491014747 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 218491014748 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 218491014749 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 218491014750 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 3e-08 218491014751 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 218491014752 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014753 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 218491014754 SLBB domain; Region: SLBB; pfam10531 218491014755 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 218491014756 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 218491014757 HMMPfam hit to PF01512, DE Respiratory-chain NADH dehydrogenase 51 Kd subunit, score 2.1e-172 218491014758 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 218491014759 NADH dehydrogenase subunit E; Validated; Region: PRK07539 218491014760 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 218491014761 putative dimer interface [polypeptide binding]; other site 218491014762 [2Fe-2S] cluster binding site [ion binding]; other site 218491014763 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01257, DE Respiratory-chain NADH dehydrogenase 24 Kd subunit, score 3.5e-91 218491014764 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 218491014765 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 218491014766 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 218491014767 NADH dehydrogenase subunit D; Validated; Region: PRK06075 218491014768 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00346, DE Respiratory-chain NADH dehydrogenase, 49 Kd subunit, score 2.1e-174 218491014769 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 218491014770 HMMPfam hit to PF00329, DE Respiratory-chain NADH dehydrogenase, 30 Kd subunit, score 5.5e-39 218491014771 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 218491014772 HMMPfam hit to PF01058, DE NADH ubiquinone oxidoreductase, 20 Kd subunit, score 5.6e-52 218491014773 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 218491014774 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491014775 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 218491014776 HMMPfam hit to PF00507, DE NADH-ubiquinone/plastoquinone oxidoreductase, chain 3, score 3.1e-40 218491014777 3 probable transmembrane helices predicted for ECA3028 by TMHMM2.0 at aa 15-37, 66-88 and 98-120 218491014778 PS00012 Phosphopantetheine attachment site. 218491014779 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 218491014780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014781 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 218491014782 putative dimerization interface [polypeptide binding]; other site 218491014783 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.6e-31 218491014784 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.4e-23 218491014785 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014786 Predicted helix-turn-helix motif with score 1338.000, SD 3.74 at aa 26-47, sequence NTFAAAAAAVNRTQSAVSQQMQ 218491014787 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 218491014788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491014789 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 218491014790 putative dimerization interface [polypeptide binding]; other site 218491014791 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.6e-31 218491014792 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.4e-23 218491014793 PS00044 Bacterial regulatory proteins, lysR family signature. 218491014794 Predicted helix-turn-helix motif with score 1338.000, SD 3.74 at aa 26-47, sequence NTFAAAAAAVNRTQSAVSQQMQ 218491014795 aminotransferase AlaT; Validated; Region: PRK09265 218491014796 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491014797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491014798 homodimer interface [polypeptide binding]; other site 218491014799 catalytic residue [active] 218491014800 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 1.2e-31 218491014801 5'-nucleotidase; Provisional; Region: PRK03826 218491014802 HMMPfam hit to PF01966, DE HD domain, score 6.7e-08 218491014803 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 218491014804 transmembrane helices; other site 218491014805 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218491014806 TrkA-C domain; Region: TrkA_C; pfam02080 218491014807 TrkA-C domain; Region: TrkA_C; pfam02080 218491014808 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 218491014809 10 probable transmembrane helices predicted for ECA3035 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 111-142, 149-171, 186-208, 481-503, 518-540, 561-583 and 603-625 218491014810 PS01271 Sodium:sulfate symporter family signature. 218491014811 HMMPfam hit to PF02080, DE TrkA-C domain, score 1.3e-14 218491014812 HMMPfam hit to PF02080, DE TrkA-C domain, score 3.8e-15 218491014813 putative phosphatase; Provisional; Region: PRK11587 218491014814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491014815 motif II; other site 218491014816 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 8.4e-32 218491014817 hypothetical protein; Validated; Region: PRK05445 218491014818 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03887, DE YfbU domain, score 1.1e-101 218491014819 hypothetical protein; Provisional; Region: PRK01816 218491014820 2 probable transmembrane helices predicted for ECA3038 by TMHMM2.0 at aa 46-65 and 69-91 218491014821 propionate/acetate kinase; Provisional; Region: PRK12379 218491014822 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 218491014823 HMMPfam hit to PF00871, DE Acetokinase family, score 7.7e-238 218491014824 PS01075 Acetate and butyrate kinases family signature 1. 218491014825 PS01076 Acetate and butyrate kinases family signature 2. 218491014826 phosphate acetyltransferase; Reviewed; Region: PRK05632 218491014827 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218491014828 DRTGG domain; Region: DRTGG; pfam07085 218491014829 phosphate acetyltransferase; Region: pta; TIGR00651 218491014830 HMMPfam hit to PF01515, DE Phosphate acetyl/butaryl transferase, score 1.9e-186 218491014831 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 218491014832 6 probable transmembrane helices predicted for ECA3041 by TMHMM2.0 at aa 44-66, 129-151, 163-185, 189-208, 221-243 and 258-275 218491014833 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 218491014834 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 218491014835 nudix motif; other site 218491014836 HMMPfam hit to PF00293, DE NUDIX domain, score 3.3e-22 218491014837 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 218491014838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218491014839 active site 218491014840 metal binding site [ion binding]; metal-binding site 218491014841 homotetramer interface [polypeptide binding]; other site 218491014842 PS01269 Uncharacterized protein family UPF0025 signature. 218491014843 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 5e-17 218491014844 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 218491014845 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 218491014846 C-terminal domain interface [polypeptide binding]; other site 218491014847 GSH binding site (G-site) [chemical binding]; other site 218491014848 dimer interface [polypeptide binding]; other site 218491014849 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 218491014850 N-terminal domain interface [polypeptide binding]; other site 218491014851 putative dimer interface [polypeptide binding]; other site 218491014852 active site 218491014853 HMMPfam hit to PF02798, DE Glutathione S-transferase, N-terminal domain, score 4.8e-08 218491014854 HMMPfam hit to PF00043, DE Glutathione S-transferase, C-terminal domain, score 1.7e-11 218491014855 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 218491014856 homooctamer interface [polypeptide binding]; other site 218491014857 active site 218491014858 HMMPfam hit to PF02152, DE Dihydroneopterin aldolase, score 6.1e-35 218491014859 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 218491014860 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 218491014861 putative NAD(P) binding site [chemical binding]; other site 218491014862 putative active site [active] 218491014863 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 218491014864 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491014865 Walker A/P-loop; other site 218491014866 ATP binding site [chemical binding]; other site 218491014867 Q-loop/lid; other site 218491014868 ABC transporter signature motif; other site 218491014869 Walker B; other site 218491014870 D-loop; other site 218491014871 H-loop/switch region; other site 218491014872 HMMPfam hit to PF00005, DE ABC transporter, score 1e-61 218491014873 PS00211 ABC transporters family signature. 218491014874 PS00017 ATP/GTP-binding site motif A (P-loop). 218491014875 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491014876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014877 dimer interface [polypeptide binding]; other site 218491014878 conserved gate region; other site 218491014879 putative PBP binding loops; other site 218491014880 ABC-ATPase subunit interface; other site 218491014881 5 probable transmembrane helices predicted for ECA3048 by TMHMM2.0 at aa 20-42, 55-77, 97-116, 167-189 and 199-221 218491014882 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.1e-09 218491014883 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491014884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491014885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491014886 dimer interface [polypeptide binding]; other site 218491014887 conserved gate region; other site 218491014888 putative PBP binding loops; other site 218491014889 ABC-ATPase subunit interface; other site 218491014890 5 probable transmembrane helices predicted for ECA3049 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 149-171 and 191-213 218491014891 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.4e-13 218491014892 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491014893 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 218491014894 Signal peptide predicted for ECA3050 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22; signal peptide 218491014895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491014896 substrate binding pocket [chemical binding]; other site 218491014897 membrane-bound complex binding site; other site 218491014898 hinge residues; other site 218491014899 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 4.3e-77 218491014900 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491014901 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 218491014902 Flavoprotein; Region: Flavoprotein; pfam02441 218491014903 HMMPfam hit to PF02441, DE Flavoprotein, score 1.6e-48 218491014904 amidophosphoribosyltransferase; Provisional; Region: PRK09246 218491014905 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 218491014906 active site 218491014907 tetramer interface [polypeptide binding]; other site 218491014908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491014909 active site 218491014910 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 4.3e-11 218491014911 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491014912 HMMPfam hit to PF00310, DE Glutamine amidotransferases class-II, score 1.6e-101 218491014913 PS00443 Glutamine amidotransferases class-II active site. 218491014914 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 218491014915 colicin V production protein; Provisional; Region: PRK10845 218491014916 HMMPfam hit to PF02674, DE Colicin V production protein, score 5.8e-59 218491014917 4 probable transmembrane helices predicted for ECA3053 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 218491014918 cell division protein DedD; Provisional; Region: PRK11633 218491014919 Sporulation related domain; Region: SPOR; pfam05036 218491014920 1 probable transmembrane helix predicted for ECA3054 by TMHMM2.0 at aa 7-29 218491014921 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 218491014922 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218491014923 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218491014924 HMMPfam hit to PF02875, DE Mur ligase family, glutamate ligase domain, score 0.0032 218491014925 PS01012 Folylpolyglutamate synthase signature 2. 218491014926 PS01011 Folylpolyglutamate synthase signature 1. 218491014927 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 218491014928 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 218491014929 hypothetical protein; Provisional; Region: PRK10847 218491014930 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218491014931 4 probable transmembrane helices predicted for ECA3057 by TMHMM2.0 at aa 28-50, 72-94, 157-179 and 189-211 218491014932 HMMPfam hit to PF00597, DE DedA family, score 7.8e-57 218491014933 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 218491014934 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 218491014935 dimerization interface 3.5A [polypeptide binding]; other site 218491014936 active site 218491014937 HMMPfam hit to PF01416, DE tRNA pseudouridine synthase, score 3.5e-28 218491014938 HMMPfam hit to PF01416, DE tRNA pseudouridine synthase, score 1.1e-32 218491014939 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 218491014940 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218491014941 HMMPfam hit to PF02774, DE Semialdehyde dehydrogenase, dimerisation domain, score 2.1e-41 218491014942 HMMPfam hit to PF01118, DE Semialdehyde dehydrogenase, NAD binding domain, score 1.9e-46 218491014943 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 218491014944 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 218491014945 ligand binding site [chemical binding]; other site 218491014946 NAD binding site [chemical binding]; other site 218491014947 catalytic site [active] 218491014948 homodimer interface [polypeptide binding]; other site 218491014949 HMMPfam hit to PF02826, DE D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 6.1e-48 218491014950 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 218491014951 HMMPfam hit to PF00389, DE D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 4.8e-14 218491014952 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218491014953 EamA-like transporter family; Region: EamA; pfam00892 218491014954 10 probable transmembrane helices predicted for ECA3061 by TMHMM2.0 at aa 2-19, 34-56, 63-85, 90-112, 117-139, 143-165, 178-200, 210-229, 242-259 and 263-280 218491014955 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 4.3e-21 218491014956 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 8e-21 218491014957 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 218491014958 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 218491014959 1 probable transmembrane helix predicted for ECA3062 by TMHMM2.0 at aa 399-416 218491014960 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 218491014961 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218491014962 dimer interface [polypeptide binding]; other site 218491014963 active site 218491014964 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 4.8e-56 218491014965 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 2.3e-53 218491014966 PS00606 Beta-ketoacyl synthases active site. 218491014967 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 218491014968 Uncharacterized conserved protein [Function unknown]; Region: COG4121 218491014969 YfcL protein; Region: YfcL; pfam08891 218491014970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 218491014971 hypothetical protein; Provisional; Region: PRK10621 218491014972 Predicted permeases [General function prediction only]; Region: COG0730 218491014973 HMMPfam hit to PF01925, DE Domain of unknown function DUF81, score 4.7e-35 218491014974 7 probable transmembrane helices predicted for ECA3067 by TMHMM2.0 at aa 12-34, 49-68, 81-100, 104-122, 135-154, 159-178 and 191-213 218491014975 Signal peptide predicted for ECA3068 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25; signal peptide 218491014976 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 218491014977 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 218491014978 HMMPfam hit to PF03411, DE Penicillin-insensitive murein endopeptidase, score 3.5e-148 218491014979 1 probable transmembrane helix predicted for ECA3068 by TMHMM2.0 at aa 5-24 218491014980 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 218491014981 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 218491014982 Tetramer interface [polypeptide binding]; other site 218491014983 active site 218491014984 FMN-binding site [chemical binding]; other site 218491014985 HMMPfam hit to PF01264, DE Chorismate synthase, score 1.5e-237 218491014986 PS00789 Chorismate synthase signature 3. 218491014987 PS00788 Chorismate synthase signature 2. 218491014988 PS00787 Chorismate synthase signature 1. 218491014989 HemK family putative methylases; Region: hemK_fam; TIGR00536 218491014990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491014991 S-adenosylmethionine binding site [chemical binding]; other site 218491014992 PS00092 N-6 Adenine-specific DNA methylases signature. 218491014993 hypothetical protein; Provisional; Region: PRK04946 218491014994 Smr domain; Region: Smr; pfam01713 218491014995 HMMPfam hit to PF01713, DE Smr domain, score 5.7e-30 218491014996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218491014997 catalytic core [active] 218491014998 Signal peptide predicted for ECA3073 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.809 between residues 26 and 27; signal peptide 218491014999 Spore Coat Protein U domain; Region: SCPU; pfam05229 218491015000 Signal peptide predicted for ECA3074 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.941 between residues 24 and 25; signal peptide 218491015001 Spore Coat Protein U domain; Region: SCPU; pfam05229 218491015002 Signal peptide predicted for ECA3075 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 21 and 22; signal peptide 218491015003 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 218491015004 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 218491015005 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015006 Signal peptide predicted for ECA3076 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.976 between residues 31 and 32; signal peptide 218491015007 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 218491015008 PapC N-terminal domain; Region: PapC_N; pfam13954 218491015009 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 218491015010 PapC C-terminal domain; Region: PapC_C; pfam13953 218491015011 HMMPfam hit to PF00577, DE Fimbrial Usher protein, score 1.1e-12 218491015012 Signal peptide predicted for ECA3077 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.960 between residues 39 and 40; signal peptide 218491015013 Spore Coat Protein U domain; Region: SCPU; pfam05229 218491015014 Spore Coat Protein U domain; Region: SCPU; pfam05229 218491015015 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 218491015016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218491015017 substrate binding site [chemical binding]; other site 218491015018 oxyanion hole (OAH) forming residues; other site 218491015019 trimer interface [polypeptide binding]; other site 218491015020 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 218491015021 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218491015022 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 218491015023 HMMPfam hit to PF00725, DE 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, score 0.0026 218491015024 HMMPfam hit to PF00725, DE 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, score 6.4e-36 218491015025 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 218491015026 HMMPfam hit to PF02737, DE 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, score 3.6e-85 218491015027 HMMPfam hit to PF00378, DE Enoyl-CoA hydratase/isomerase family, score 1.5e-61 218491015028 PS00166 Enoyl-CoA hydratase/isomerase signature. 218491015029 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 218491015030 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218491015031 dimer interface [polypeptide binding]; other site 218491015032 active site 218491015033 HMMPfam hit to PF02803, DE Thiolase, C-terminal domain, score 8.2e-48 218491015034 PS00099 Thiolases active site. 218491015035 PS00737 Thiolases signature 2. 218491015036 HMMPfam hit to PF00108, DE Thiolase, N-terminal domain, score 5.5e-67 218491015037 PS00098 Thiolases acyl-enzyme intermediate signature. 218491015038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 218491015039 Signal peptide predicted for ECA3081 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 27 and 28; signal peptide 218491015040 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 218491015041 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491015042 Signal peptide predicted for ECA3082 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.974 between residues 22 and 23; signal peptide 218491015043 malate:quinone oxidoreductase; Validated; Region: PRK05257 218491015044 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 218491015045 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 218491015046 Signal peptide predicted for ECA3083 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.820 between residues 25 and 26; signal peptide 218491015047 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015048 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 218491015049 6 probable transmembrane helices predicted for ECA3084 by TMHMM2.0 at aa 63-85, 89-111, 144-166, 192-211, 218-237 and 257-279 218491015050 Signal peptide predicted for ECA3085 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22; signal peptide 218491015051 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218491015052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491015053 Coenzyme A binding pocket [chemical binding]; other site 218491015054 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 9e-06 218491015055 Signal peptide predicted for ECA3087 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23; signal peptide 218491015056 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 218491015057 Signal peptide predicted for ECA3088 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.968 between residues 22 and 23; signal peptide 218491015058 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 218491015059 Serine hydrolase; Region: Ser_hydrolase; pfam06821 218491015060 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015061 PS00120 Lipases, serine active site. 218491015062 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 218491015063 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218491015064 ATP binding site [chemical binding]; other site 218491015065 Mg++ binding site [ion binding]; other site 218491015066 motif III; other site 218491015067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491015068 nucleotide binding region [chemical binding]; other site 218491015069 ATP-binding site [chemical binding]; other site 218491015070 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 218491015071 putative RNA binding site [nucleotide binding]; other site 218491015072 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03880, DE DbpA RNA binding domain, score 4.5e-34 218491015073 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 5.4e-30 218491015074 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 2.6e-71 218491015075 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491015076 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015077 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218491015078 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 218491015079 HMMPfam hit to PF03697, , score 1.6e-11 218491015080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218491015081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491015082 Walker A/P-loop; other site 218491015083 ATP binding site [chemical binding]; other site 218491015084 Q-loop/lid; other site 218491015085 ABC transporter signature motif; other site 218491015086 Walker B; other site 218491015087 D-loop; other site 218491015088 H-loop/switch region; other site 218491015089 HMMPfam hit to PF00005, DE ABC transporter, score 1.9e-41 218491015090 PS00211 ABC transporters family signature. 218491015091 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015092 Signal peptide predicted for ECA3095 by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.301 between residues 31 and 32; signal peptide 218491015093 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491015094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491015095 ABC-ATPase subunit interface; other site 218491015096 dimer interface [polypeptide binding]; other site 218491015097 putative PBP binding regions; other site 218491015098 HMMPfam hit to PF01032, DE FecCD transport family, score 1.2e-101 218491015099 8 probable transmembrane helices predicted for ECA3095 by TMHMM2.0 at aa 7-29, 68-90, 97-119, 123-145, 150-172, 192-214, 243-265 and 311-330 218491015100 Signal peptide predicted for ECA3096 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.997 between residues 23 and 24; signal peptide 218491015101 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 218491015102 putative ligand binding residues [chemical binding]; other site 218491015103 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 218491015104 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 6e-31 218491015105 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 218491015106 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 218491015107 HMMPfam hit to PF00296, DE Luciferase-like monooxygenase, score 8.1e-08 218491015108 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 218491015109 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 218491015110 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 218491015111 HMMPfam hit to PF01478, DE Type IV leader peptidase family, score 2.6e-152 218491015112 6 probable transmembrane helices predicted for ECA3098 by TMHMM2.0 at aa 13-35, 106-128, 138-171, 178-200, 226-248 and 261-280 218491015113 Signal peptide predicted for ECA3099 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.553 between residues 42 and 43; signal peptide 218491015114 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 218491015115 HMMPfam hit to PF01203, DE Bacterial type II secretion system protein N, score 4.5e-149 218491015116 PS01142 Bacterial type II secretion system protein N signature. 218491015117 1 probable transmembrane helix predicted for ECA3099 by TMHMM2.0 at aa 7-29 218491015118 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 218491015119 1 probable transmembrane helix predicted for ECA3100 by TMHMM2.0 at aa 20-39 218491015120 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 218491015121 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 218491015122 GspL periplasmic domain; Region: GspL_C; pfam12693 218491015123 Signal peptide predicted for ECA3102 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.683 between residues 24 and 25; signal peptide 218491015124 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 218491015125 HMMPfam hit to PF03934, DE General secretion pathway protein K, score 2.4e-90 218491015126 Signal peptide predicted for ECA3103 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.587 between residues 30 and 31; signal peptide 218491015127 type II secretion system protein J; Region: gspJ; TIGR01711 218491015128 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 218491015129 HMMPfam hit to PF02501, DE Bacterial type II secretion system protein I/J, score 0.0003 218491015130 1 probable transmembrane helix predicted for ECA3103 by TMHMM2.0 at aa 9-31 218491015131 PS00409 Prokaryotic N-terminal methylation site. 218491015132 Signal peptide predicted for ECA3104 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.381 between residues 34 and 35; signal peptide 218491015133 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 218491015134 type II secretion system protein I; Region: gspI; TIGR01707 218491015135 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 218491015136 HMMPfam hit to PF02501, DE Bacterial type II secretion system protein I/J, score 3.7e-66 218491015137 PS00409 Prokaryotic N-terminal methylation site. 218491015138 Signal peptide predicted for ECA3105 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.779 between residues 33 and 34; signal peptide 218491015139 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 218491015140 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 218491015141 1 probable transmembrane helix predicted for ECA3105 by TMHMM2.0 at aa 13-35 218491015142 PS00409 Prokaryotic N-terminal methylation site. 218491015143 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 218491015144 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 218491015145 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 218491015146 1 probable transmembrane helix predicted for ECA3106 by TMHMM2.0 at aa 12-34 218491015147 PS00409 Prokaryotic N-terminal methylation site. 218491015148 type II secretion system protein F; Region: GspF; TIGR02120 218491015149 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218491015150 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218491015151 HMMPfam hit to PF00482, DE Bacterial type II secretion system protein F domain, score 3e-200 218491015152 3 probable transmembrane helices predicted for ECA3107 by TMHMM2.0 at aa 173-195, 226-245 and 379-401 218491015153 PS00874 Bacterial type II secretion system protein F signature. 218491015154 type II secretion system protein E; Region: type_II_gspE; TIGR02533 218491015155 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 218491015156 Walker A motif; other site 218491015157 ATP binding site [chemical binding]; other site 218491015158 Walker B motif; other site 218491015159 HMMPfam hit to PF00437, DE Type II/IV secretion system protein, score 2.6e-197 218491015160 PS00662 Bacterial type II secretion system protein E signature. 218491015161 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015162 Signal peptide predicted for ECA3109 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 63 and 64; signal peptide 218491015163 type II secretion system protein D; Region: type_II_gspD; TIGR02517 218491015164 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218491015165 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218491015166 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218491015167 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218491015168 HMMPfam hit to PF00263, DE Bacterial type II and III secretion system protein, score 1.2e-107 218491015169 PS00875 Bacterial type II secretion system protein D signature. 218491015170 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 218491015171 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 218491015172 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 0.019 218491015173 PS01141 Bacterial type II secretion system protein C signature. 218491015174 1 probable transmembrane helix predicted for ECA3110 by TMHMM2.0 at aa 30-52 218491015175 Signal peptide predicted for ECA3111 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.645 between residues 28 and 29; signal peptide 218491015176 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 218491015177 Interdomain contacts; other site 218491015178 Cytokine receptor motif; other site 218491015179 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 218491015180 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 218491015181 HMMPfam hit to PF00295, DE Glycosyl hydrolases family 28, score 3.7e-05 218491015182 HMMPfam hit to PF00041, DE Fibronectin type III domain, score 8.7e-05 218491015183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015184 Signal peptide predicted for ECA3112 by SignalP 2.0 HMM (Signal peptide probabilty 0.935) with cleavage site probability 0.529 between residues 31 and 32; signal peptide 218491015185 Amb_all domain; Region: Amb_all; smart00656 218491015186 HMMPfam hit to PF00544, DE Pectate lyase, score 2.6e-38 218491015187 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015188 1 probable transmembrane helix predicted for ECA3113 by TMHMM2.0 at aa 20-39 218491015189 Signal peptide predicted for ECA3114 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.489 between residues 30 and 31; signal peptide 218491015190 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; pfam09691 218491015191 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015192 aminotransferase; Validated; Region: PRK08175 218491015193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491015194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491015195 homodimer interface [polypeptide binding]; other site 218491015196 catalytic residue [active] 218491015197 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 4.6e-40 218491015198 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 218491015199 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 218491015200 active site 218491015201 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 6e-12 218491015202 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 2.3e-20 218491015203 PS00501 Signal peptidases I serine active site. 218491015204 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 218491015205 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 218491015206 homodimer interface [polypeptide binding]; other site 218491015207 substrate-cofactor binding pocket; other site 218491015208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491015209 catalytic residue [active] 218491015210 HMMPfam hit to PF01063, DE Aminotransferase class IV, score 1.3e-65 218491015211 PS00770 Aminotransferases class-IV signature. 218491015212 Signal peptide predicted for ECA3118 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.592 between residues 26 and 27; signal peptide 218491015213 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 218491015214 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 218491015215 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218491015216 HMMPfam hit to PF00924, DE Mechanosensitive ion channel, score 8.6e-44 218491015217 11 probable transmembrane helices predicted for ECA3118 by TMHMM2.0 at aa 7-29, 217-239, 259-281, 301-320, 341-363, 368-390, 414-436, 441-463, 497-516, 546-565 and 586-608 218491015218 Protein of unknown function DUF91; Region: DUF91; cl00709 218491015219 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 218491015220 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218491015221 HMMPfam hit to PF01420, DE Type I restriction modification DNA specificity domain, score 0.00048 218491015222 HsdM N-terminal domain; Region: HsdM_N; pfam12161 218491015223 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 218491015224 Methyltransferase domain; Region: Methyltransf_26; pfam13659 218491015225 HMMPfam hit to PF02384, DE N-6 DNA Methylase, score 1.7e-60 218491015226 PS00092 N-6 Adenine-specific DNA methylases signature. 218491015227 HMMPfam hit to PF02506, DE Type I restriction modification system, M protein, score 4.8e-06 218491015228 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 218491015229 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 218491015230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491015231 ATP binding site [chemical binding]; other site 218491015232 putative Mg++ binding site [ion binding]; other site 218491015233 PS00215 Mitochondrial energy transfer proteins signature. 218491015234 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 0.43 218491015235 Signal peptide predicted for ECA3123 by SignalP 2.0 HMM (Signal peptide probabilty 0.944) with cleavage site probability 0.633 between residues 40 and 41; signal peptide 218491015236 3 probable transmembrane helices predicted for ECA3123 by TMHMM2.0 at aa 16-38, 43-65 and 72-94 218491015237 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 218491015238 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 218491015239 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015240 methionine synthase; Provisional; Region: PRK01207 218491015241 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 218491015242 substrate binding site [chemical binding]; other site 218491015243 THF binding site; other site 218491015244 zinc-binding site [ion binding]; other site 218491015245 HMMPfam hit to PF01717, DE Methionine synthase, vitamin-B12 independent, score 1.8e-19 218491015246 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 218491015247 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 218491015248 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 218491015249 acyl-activating enzyme (AAE) consensus motif; other site 218491015250 AMP binding site [chemical binding]; other site 218491015251 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.9e-80 218491015252 PS00697 ATP-dependent DNA ligase AMP-binding site. 218491015253 PS00455 AMP-binding domain signature. 218491015254 Signal peptide predicted for ECA3129 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.389 between residues 39 and 40; signal peptide 218491015255 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 218491015256 8 probable transmembrane helices predicted for ECA3129 by TMHMM2.0 at aa 5-27, 42-64, 124-143, 163-185, 198-220, 287-304, 311-330 and 345-367 218491015257 Signal peptide predicted for ECA3130 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.657 between residues 29 and 30; signal peptide 218491015258 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 218491015259 Signal peptide predicted for ECA3132 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.729 between residues 27 and 28; signal peptide 218491015260 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491015262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491015263 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 218491015264 putative effector binding pocket; other site 218491015265 putative dimerization interface [polypeptide binding]; other site 218491015266 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03466, DE LysR substrate binding domain, score 4.3e-43 218491015267 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.7e-26 218491015268 PS00044 Bacterial regulatory proteins, lysR family signature. 218491015269 Predicted helix-turn-helix motif with score 2016.000, SD 6.05 at aa 28-49, sequence RSFTKAAAKLGLSQSALSHSIR 218491015270 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 218491015271 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 218491015272 active site 218491015273 methionine cluster; other site 218491015274 phosphorylation site [posttranslational modification] 218491015275 metal binding site [ion binding]; metal-binding site 218491015276 HMMPfam hit to PF02255, DE PTS system, Lactose/Cellobiose specific IIA subunit, score 1.2e-23 218491015277 Signal peptide predicted for ECA3137 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 26 and 27; signal peptide 218491015278 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 218491015279 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218491015280 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 1.4e-21 218491015281 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 218491015282 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 218491015283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015284 dimer interface [polypeptide binding]; other site 218491015285 conserved gate region; other site 218491015286 ABC-ATPase subunit interface; other site 218491015287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015288 dimer interface [polypeptide binding]; other site 218491015289 conserved gate region; other site 218491015290 putative PBP binding loops; other site 218491015291 ABC-ATPase subunit interface; other site 218491015292 12 probable transmembrane helices predicted for ECA3138 by TMHMM2.0 at aa 23-45, 69-91, 104-126, 131-153, 190-212, 232-251, 280-302, 329-351, 363-385, 390-412, 452-474 and 494-516 218491015293 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.8e-05 218491015294 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.6e-14 218491015295 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 218491015296 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 218491015297 Walker A/P-loop; other site 218491015298 ATP binding site [chemical binding]; other site 218491015299 Q-loop/lid; other site 218491015300 ABC transporter signature motif; other site 218491015301 Walker B; other site 218491015302 D-loop; other site 218491015303 H-loop/switch region; other site 218491015304 TOBE domain; Region: TOBE_2; pfam08402 218491015305 HMMPfam hit to PF00005, DE ABC transporter, score 3.4e-62 218491015306 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015307 PS00211 ABC transporters family signature. 218491015308 Signal peptide predicted for ECA3140 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.330 between residues 18 and 19; signal peptide 218491015309 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 218491015310 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 0.0068 218491015311 4 probable transmembrane helices predicted for ECA3140 by TMHMM2.0 at aa 7-29, 49-71, 78-100 and 104-123 218491015312 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 218491015313 Signal peptide predicted for ECA3141 by SignalP 2.0 HMM (Signal peptide probabilty 0.886) with cleavage site probability 0.456 between residues 23 and 24; signal peptide 218491015314 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 0.03 218491015315 3 probable transmembrane helices predicted for ECA3141 by TMHMM2.0 at aa 39-61, 66-88 and 95-112 218491015316 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 218491015317 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 218491015318 11 probable transmembrane helices predicted for ECA3142 by TMHMM2.0 at aa 12-31, 86-108, 115-137, 178-200, 207-229, 260-282, 295-312, 316-338, 351-373, 383-405 and 412-434 218491015319 HMMPfam hit to PF02366, DE Dolichyl-phosphate-mannose-protein mannosyltransferase, score 4.6e-39 218491015320 PS00041 Bacterial regulatory proteins, araC family signature. 218491015321 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 218491015322 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 218491015323 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 218491015324 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 218491015325 active site 218491015326 substrate binding site [chemical binding]; other site 218491015327 cosubstrate binding site; other site 218491015328 catalytic site [active] 218491015329 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 218491015330 active site 218491015331 hexamer interface [polypeptide binding]; other site 218491015332 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 218491015333 NAD binding site [chemical binding]; other site 218491015334 substrate binding site [chemical binding]; other site 218491015335 active site 218491015336 HMMPfam hit to PF02911, DE Formyl transferase, C-terminal domain, score 2.2e-17 218491015337 HMMPfam hit to PF00551, DE Formyl transferase, score 5.6e-14 218491015338 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 218491015339 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 218491015340 Ligand binding site; other site 218491015341 Putative Catalytic site; other site 218491015342 DXD motif; other site 218491015343 2 probable transmembrane helices predicted for ECA3145 by TMHMM2.0 at aa 231-253 and 268-290 218491015344 HMMPfam hit to PF00535, DE Glycosyl transferase, score 4.9e-34 218491015345 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 218491015346 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218491015347 inhibitor-cofactor binding pocket; inhibition site 218491015348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491015349 catalytic residue [active] 218491015350 HMMPfam hit to PF01041, DE DegT/DnrJ/EryC1/StrS aminotransferase family, score 1.1e-166 218491015351 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 218491015352 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 218491015353 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 218491015354 HMMPfam hit to PF03720, DE UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain, score 0.00014 218491015355 HMMPfam hit to PF00984, DE UDP-glucose/GDP-mannose dehydrogenase family, central domain, score 1e-34 218491015356 HMMPfam hit to PF03721, DE UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain, score 3.2e-43 218491015357 Signal peptide predicted for ECA3148 by SignalP 2.0 HMM (Signal peptide probabilty 0.778) with cleavage site probability 0.426 between residues 33 and 34; signal peptide 218491015358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491015359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491015360 metal binding site [ion binding]; metal-binding site 218491015361 active site 218491015362 I-site; other site 218491015363 2 probable transmembrane helices predicted for ECA3148 by TMHMM2.0 at aa 21-40 and 294-316 218491015364 HMMPfam hit to PF00990, DE GGDEF domain, score 2.4e-54 218491015365 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 218491015366 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 218491015367 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 218491015368 homodimer interface [polypeptide binding]; other site 218491015369 NADP binding site [chemical binding]; other site 218491015370 substrate binding site [chemical binding]; other site 218491015371 HMMPfam hit to PF00763, DE Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, score 3e-65 218491015372 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015373 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 218491015374 HMMPfam hit to PF02882, DE Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, score 2.1e-100 218491015375 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 218491015376 ribosome-associated protein; Provisional; Region: PRK11507 218491015377 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 218491015378 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218491015379 active site 218491015380 HIGH motif; other site 218491015381 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218491015382 KMSKS motif; other site 218491015383 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 218491015384 tRNA binding surface [nucleotide binding]; other site 218491015385 anticodon binding site; other site 218491015386 HMMPfam hit to PF01406, DE tRNA synthetases class I (C), score 4.5e-273 218491015387 DoxX; Region: DoxX; pfam07681 218491015388 4 probable transmembrane helices predicted for ECA3152 by TMHMM2.0 at aa 21-43, 53-75, 80-97 and 107-129 218491015389 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 218491015390 substrate binding site [chemical binding]; other site 218491015391 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00160, DE Cyclophilin type peptidyl-prolyl cis-trans isomerase, score 6.4e-60 218491015392 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 218491015393 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 218491015394 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218491015395 putative active site [active] 218491015396 putative metal binding site [ion binding]; other site 218491015397 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 8.4e-14 218491015398 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 218491015399 HMMPfam hit to PF00731, DE AIR carboxylase, score 5.1e-95 218491015400 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 218491015401 ATP-grasp domain; Region: ATP-grasp; pfam02222 218491015402 HMMPfam hit to PF02222, DE ATP-grasp domain, score 7e-11 218491015403 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 218491015404 serine transporter; Region: stp; TIGR00814 218491015405 11 probable transmembrane helices predicted for ECA3158 by TMHMM2.0 at aa 23-40, 44-66, 100-119, 139-158, 165-187, 207-229, 249-271, 298-320, 341-363, 368-390 and 403-425 218491015406 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 218491015407 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218491015408 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 218491015409 HMMPfam hit to PF03315, DE Serine dehydratase beta chain, score 6.2e-88 218491015410 PS00368 Ribonucleotide reductase small subunit signature. 218491015411 HMMPfam hit to PF03313, DE Serine dehydratase alpha chain, score 1.1e-185 218491015412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 218491015413 non-specific DNA binding site [nucleotide binding]; other site 218491015414 salt bridge; other site 218491015415 sequence-specific DNA binding site [nucleotide binding]; other site 218491015416 HMMPfam hit to PF01381, DE Helix-turn-helix, score 0.0012 218491015417 Predicted helix-turn-helix motif with score 1492.000, SD 4.27 at aa 28-49, sequence ISQVDLAERAGLGIATIKRAEM 218491015418 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 218491015419 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 218491015420 Walker A/P-loop; other site 218491015421 ATP binding site [chemical binding]; other site 218491015422 Q-loop/lid; other site 218491015423 ABC transporter signature motif; other site 218491015424 Walker B; other site 218491015425 D-loop; other site 218491015426 H-loop/switch region; other site 218491015427 HMMPfam hit to PF00005, DE ABC transporter, score 5.2e-60 218491015428 PS00211 ABC transporters family signature. 218491015429 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015430 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 218491015431 Signal peptide predicted for ECA3162 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.455 between residues 34 and 35; signal peptide 218491015432 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 218491015433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015434 dimer interface [polypeptide binding]; other site 218491015435 conserved gate region; other site 218491015436 ABC-ATPase subunit interface; other site 218491015437 6 probable transmembrane helices predicted for ECA3162 by TMHMM2.0 at aa 12-34, 303-325, 345-367, 387-406, 432-454 and 513-535 218491015438 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.3e-11 218491015439 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491015440 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 218491015441 Signal peptide predicted for ECA3163 by SignalP 2.0 HMM (Signal peptide probabilty 0.818) with cleavage site probability 0.710 between residues 59 and 60; signal peptide 218491015442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015443 dimer interface [polypeptide binding]; other site 218491015444 conserved gate region; other site 218491015445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015446 dimer interface [polypeptide binding]; other site 218491015447 conserved gate region; other site 218491015448 putative PBP binding loops; other site 218491015449 ABC-ATPase subunit interface; other site 218491015450 8 probable transmembrane helices predicted for ECA3163 by TMHMM2.0 at aa 21-43, 426-448, 461-480, 484-506, 527-549, 569-588, 617-639 and 682-704 218491015451 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 8.8e-14 218491015452 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491015453 polyphosphate kinase; Provisional; Region: PRK05443 218491015454 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 218491015455 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 218491015456 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 218491015457 domain interface [polypeptide binding]; other site 218491015458 active site 218491015459 catalytic site [active] 218491015460 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 218491015461 domain interface [polypeptide binding]; other site 218491015462 active site 218491015463 catalytic site [active] 218491015464 HMMPfam hit to PF02503, DE Polyphosphate kinase, score 0 218491015465 exopolyphosphatase; Provisional; Region: PRK10854 218491015466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218491015467 nucleotide binding site [chemical binding]; other site 218491015468 HMMPfam hit to PF02541, DE Ppx/GppA phosphatase family, score 1.8e-125 218491015469 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 218491015470 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02566, DE OsmC-like protein, score 1e-39 218491015471 Transcriptional regulators [Transcription]; Region: MarR; COG1846 218491015472 MarR family; Region: MarR; pfam01047 218491015473 HMMPfam hit to PF01047, DE MarR family, score 4.4e-25 218491015474 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 218491015475 MgtE intracellular N domain; Region: MgtE_N; smart00924 218491015476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 218491015477 Divalent cation transporter; Region: MgtE; cl00786 218491015478 HMMPfam hit to PF03448, DE MgtE intracellular domain, score 7.6e-08 218491015479 HMMPfam hit to PF00571, DE CBS domain, score 0.32 218491015480 HMMPfam hit to PF00571, DE CBS domain, score 1.1e-06 218491015481 5 probable transmembrane helices predicted for ECA3169 by TMHMM2.0 at aa 328-347, 352-369, 403-425, 432-454 and 469-491 218491015482 HMMPfam hit to PF01769, DE Divalent cation transporter, score 2.6e-17 218491015483 galactokinase; Provisional; Region: PRK05101 218491015484 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 218491015485 HMMPfam hit to PF00288, DE GHMP kinases ATP-binding protein, score 1.7e-84 218491015486 PS00627 GHMP kinases ATP-binding domain. 218491015487 PS00106 Galactokinase signature. 218491015488 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 218491015489 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 218491015490 dimer interface [polypeptide binding]; other site 218491015491 active site 218491015492 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02744, DE Galactose-1-phosphate uridyl transferase, C-terminal domain, score 2.8e-94 218491015493 HMMPfam hit to PF01087, DE Galactose-1-phosphate uridyl transferase, N-terminal domain, score 5.4e-97 218491015494 PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 218491015495 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 218491015496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491015497 DNA binding site [nucleotide binding] 218491015498 domain linker motif; other site 218491015499 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218491015500 dimerization interface (closed form) [polypeptide binding]; other site 218491015501 ligand binding site [chemical binding]; other site 218491015502 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 9.9e-13 218491015503 Predicted helix-turn-helix motif with score 2086.000, SD 6.29 at aa 2-23, sequence ATIKDVARLSGVSVATVSRVIN 218491015504 PS00356 Bacterial regulatory proteins, lacI family signature. 218491015505 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 2.1e-17 218491015506 Signal peptide predicted for ECA3173 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 23 and 24; signal peptide 218491015507 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 218491015508 trimer interface; other site 218491015509 sugar binding site [chemical binding]; other site 218491015510 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02264, DE LamB porin, score 7.4e-95 218491015511 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218491015512 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218491015513 Walker A/P-loop; other site 218491015514 ATP binding site [chemical binding]; other site 218491015515 Q-loop/lid; other site 218491015516 ABC transporter signature motif; other site 218491015517 Walker B; other site 218491015518 D-loop; other site 218491015519 H-loop/switch region; other site 218491015520 TOBE domain; Region: TOBE_2; pfam08402 218491015521 HMMPfam hit to PF00005, DE ABC transporter, score 2.8e-58 218491015522 PS00211 ABC transporters family signature. 218491015523 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015524 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 218491015525 Signal peptide predicted for ECA3175 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 26 and 27; signal peptide 218491015526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218491015527 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 6.3e-76 218491015528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015529 dimer interface [polypeptide binding]; other site 218491015530 conserved gate region; other site 218491015531 ABC-ATPase subunit interface; other site 218491015532 8 probable transmembrane helices predicted for ECA3176 by TMHMM2.0 at aa 20-42, 57-79, 111-133, 182-204, 217-239, 271-293, 313-335 and 378-400 218491015533 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 7.6e-12 218491015534 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491015535 Signal peptide predicted for ECA3177 by SignalP 2.0 HMM (Signal peptide probabilty 0.870) with cleavage site probability 0.333 between residues 38 and 39; signal peptide 218491015536 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218491015537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491015538 dimer interface [polypeptide binding]; other site 218491015539 conserved gate region; other site 218491015540 putative PBP binding loops; other site 218491015541 ABC-ATPase subunit interface; other site 218491015542 6 probable transmembrane helices predicted for ECA3177 by TMHMM2.0 at aa 12-34, 81-100, 112-134, 144-166, 187-209 and 245-267 218491015543 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9.5e-15 218491015544 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491015545 Signal peptide predicted for ECA3178 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 28 and 29; signal peptide 218491015546 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 218491015547 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 218491015548 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 218491015549 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 218491015550 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 218491015551 PS00018 EF-hand calcium-binding domain. 218491015552 HMMPfam hit to PF02449, DE Beta-galactosidase, score 2.5e-203 218491015553 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491015554 active site turn [active] 218491015555 phosphorylation site [posttranslational modification] 218491015556 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 2.8e-10 218491015557 D-lactate dehydrogenase; Provisional; Region: PRK11183 218491015558 FAD binding domain; Region: FAD_binding_4; pfam01565 218491015559 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 218491015560 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 218491015561 HMMPfam hit to PF01565, DE FAD binding domain, score 9.1e-12 218491015562 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491015563 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491015564 active site 218491015565 catalytic tetrad [active] 218491015566 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 8.1e-60 218491015567 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 218491015568 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 218491015569 Nucleoside recognition; Region: Gate; pfam07670 218491015570 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 218491015571 8 probable transmembrane helices predicted for ECA3183 by TMHMM2.0 at aa 5-24, 44-66, 91-113, 197-219, 245-267, 274-296, 340-362 and 375-397 218491015572 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01773, DE Na+ dependent nucleoside transporter, score 2.9e-188 218491015573 Signal peptide predicted for ECA3184 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.584 between residues 32 and 33; signal peptide 218491015574 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 218491015575 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491015576 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491015577 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 3.5e-13 218491015578 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 218491015579 Protein export membrane protein; Region: SecD_SecF; cl14618 218491015580 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 0 218491015581 11 probable transmembrane helices predicted for ECA3185 by TMHMM2.0 at aa 15-37, 343-365, 369-391, 398-420, 440-462, 474-496, 535-557, 867-889, 909-931, 968-990 and 1000-1022 218491015582 PS01331 Thymidylate kinase signature. 218491015583 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 218491015584 Signal peptide predicted for ECA3186 by SignalP 2.0 HMM (Signal peptide probabilty 0.941) with cleavage site probability 0.383 between residues 54 and 55; signal peptide 218491015585 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 0 218491015586 10 probable transmembrane helices predicted for ECA3186 by TMHMM2.0 at aa 12-34, 336-353, 360-382, 431-450, 463-485, 525-547, 853-875, 895-917, 948-970 and 985-1007 218491015587 putative transporter; Provisional; Region: PRK10504 218491015588 Signal peptide predicted for ECA3187 by SignalP 2.0 HMM (Signal peptide probabilty 0.617) with cleavage site probability 0.612 between residues 36 and 37; signal peptide 218491015589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491015590 putative substrate translocation pore; other site 218491015591 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0092 218491015592 14 probable transmembrane helices predicted for ECA3187 by TMHMM2.0 at aa 12-34, 49-68, 75-97, 101-123, 135-157, 162-184, 196-213, 223-242, 262-284, 294-316, 328-347, 351-370, 399-421 and 431-453 218491015593 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 218491015594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491015595 dimerization interface [polypeptide binding]; other site 218491015596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491015597 dimer interface [polypeptide binding]; other site 218491015598 phosphorylation site [posttranslational modification] 218491015599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491015600 ATP binding site [chemical binding]; other site 218491015601 Mg2+ binding site [ion binding]; other site 218491015602 G-X-G motif; other site 218491015603 2 probable transmembrane helices predicted for ECA3188 by TMHMM2.0 at aa 10-32 and 160-182 218491015604 HMMPfam hit to PF00672, DE HAMP domain, score 3.4e-12 218491015605 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 9.3e-15 218491015606 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.3e-32 218491015607 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 218491015608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491015609 active site 218491015610 phosphorylation site [posttranslational modification] 218491015611 intermolecular recognition site; other site 218491015612 dimerization interface [polypeptide binding]; other site 218491015613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491015614 DNA binding site [nucleotide binding] 218491015615 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.3e-33 218491015616 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 1.6e-31 218491015617 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 218491015618 trimer interface [polypeptide binding]; other site 218491015619 active site 218491015620 substrate binding site [chemical binding]; other site 218491015621 CoA binding site [chemical binding]; other site 218491015622 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 3.9e+02 218491015623 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 82 218491015624 PS00101 Hexapeptide-repeat containing-transferases signature. 218491015625 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 6.5 218491015626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218491015627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491015628 Coenzyme A binding pocket [chemical binding]; other site 218491015629 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.1e-13 218491015630 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 218491015631 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 218491015632 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 218491015633 putative dimer interface [polypeptide binding]; other site 218491015634 N-terminal domain interface [polypeptide binding]; other site 218491015635 putative substrate binding pocket (H-site) [chemical binding]; other site 218491015636 putative protease; Provisional; Region: PRK15452 218491015637 Peptidase family U32; Region: Peptidase_U32; pfam01136 218491015638 HMMPfam hit to PF01136, DE Peptidase family U32, score 3.6e-169 218491015639 PS01276 Peptidase family U32 signature. 218491015640 lipid kinase; Reviewed; Region: PRK13054 218491015641 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 218491015642 HMMPfam hit to PF00781, DE Diacylglycerol kinase catalytic domain (presumed), score 4.2e-20 218491015643 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 218491015644 4 probable transmembrane helices predicted for ECA3195 by TMHMM2.0 at aa 13-34, 54-76, 83-102 and 112-129 218491015645 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 218491015646 dimer interface [polypeptide binding]; other site 218491015647 substrate binding site [chemical binding]; other site 218491015648 ATP binding site [chemical binding]; other site 218491015649 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 218491015650 substrate binding site [chemical binding]; other site 218491015651 multimerization interface [polypeptide binding]; other site 218491015652 ATP binding site [chemical binding]; other site 218491015653 HMMPfam hit to PF02110, DE Hydroxyethylthiazole kinase family, score 4.6e-124 218491015654 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 218491015655 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 218491015656 putative NAD(P) binding site [chemical binding]; other site 218491015657 putative substrate binding site [chemical binding]; other site 218491015658 catalytic Zn binding site [ion binding]; other site 218491015659 structural Zn binding site [ion binding]; other site 218491015660 dimer interface [polypeptide binding]; other site 218491015661 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 4.5e-80 218491015662 PS00190 Cytochrome c family heme-binding site signature. 218491015663 PS00059 Zinc-containing alcohol dehydrogenases signature. 218491015664 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 218491015665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491015666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491015667 metal binding site [ion binding]; metal-binding site 218491015668 active site 218491015669 I-site; other site 218491015670 4 probable transmembrane helices predicted for ECA3199 by TMHMM2.0 at aa 20-39, 54-76, 81-100 and 120-137 218491015671 HMMPfam hit to PF00990, DE GGDEF domain, score 7.4e-33 218491015672 Signal peptide predicted for ECA3200 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.366 between residues 26 and 27; signal peptide 218491015673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 218491015674 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 218491015675 8 probable transmembrane helices predicted for ECA3201 by TMHMM2.0 at aa 7-29, 39-57, 69-91, 96-113, 134-156, 171-190, 197-219 and 223-244 218491015676 HMMPfam hit to PF01925, DE Domain of unknown function DUF81, score 1.6e-13 218491015677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491015678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491015679 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 218491015680 putative dimerization interface [polypeptide binding]; other site 218491015681 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.3e-22 218491015682 Predicted helix-turn-helix motif with score 1725.000, SD 5.06 at aa 22-43, sequence GSLTKAAEKFHITLSALSKRIA 218491015683 PS00044 Bacterial regulatory proteins, lysR family signature. 218491015684 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.2e-33 218491015685 Signal peptide predicted for ECA3203 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.990 between residues 24 and 25; signal peptide 218491015686 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 218491015687 Signal peptide predicted for ECA3204 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22; signal peptide 218491015688 Signal peptide predicted for ECA3205 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.979 between residues 29 and 30; signal peptide 218491015689 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 218491015690 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 218491015691 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015692 HMMPfam hit to PF02275, DE Linear amide C-N hydrolases, choloylglycine hydrolase family, score 4.8e-37 218491015693 Signal peptide predicted for ECA3206 by SignalP 2.0 HMM (Signal peptide probabilty 0.688) with cleavage site probability 0.492 between residues 37 and 38; signal peptide 218491015694 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 218491015695 Predicted helix-turn-helix motif with score 1150.000, SD 3.10 at aa 20-41, sequence TTLAAVSRAAGLASSTLANALT 218491015696 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 218491015697 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 218491015698 ATP binding site [chemical binding]; other site 218491015699 HMMPfam hit to PF01163, DE RIO1 family, score 5.1e-09 218491015700 PS00109 Tyrosine protein kinases specific active-site signature. 218491015701 PS01245 RIO1/ZK632.3/MJ0444 family signature. 218491015702 GMP synthase; Reviewed; Region: guaA; PRK00074 218491015703 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 218491015704 AMP/PPi binding site [chemical binding]; other site 218491015705 candidate oxyanion hole; other site 218491015706 catalytic triad [active] 218491015707 potential glutamine specificity residues [chemical binding]; other site 218491015708 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 218491015709 ATP Binding subdomain [chemical binding]; other site 218491015710 Ligand Binding sites [chemical binding]; other site 218491015711 Dimerization subdomain; other site 218491015712 HMMPfam hit to PF00958, DE GMP synthase C terminal domain, score 3.7e-75 218491015713 HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 1.5e-48 218491015714 PS00442 Glutamine amidotransferases class-I active site. 218491015715 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 218491015716 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 218491015717 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 218491015718 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 218491015719 active site 218491015720 HMMPfam hit to PF00478, DE IMP dehydrogenase / GMP reductase domain, score 1.6e-110 218491015721 PS00487 IMP dehydrogenase / GMP reductase signature. 218491015722 HMMPfam hit to PF00571, DE CBS domain, score 2e-10 218491015723 HMMPfam hit to PF00571, DE CBS domain, score 3.7e-09 218491015724 HMMPfam hit to PF01574, , score 2.4e-57 218491015725 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 218491015726 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 218491015727 generic binding surface II; other site 218491015728 generic binding surface I; other site 218491015729 HMMPfam hit to PF01336, DE OB-fold nucleic acid binding domain, score 2.3e-07 218491015730 HMMPfam hit to PF02601, DE Exonuclease VII, large subunit, score 5.1e-82 218491015731 PS00215 Mitochondrial energy transfer proteins signature. 218491015732 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 218491015733 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 218491015734 active site 218491015735 Zn binding site [ion binding]; other site 218491015736 HMMPfam hit to PF01447, DE Thermolysin metallopeptidase, catalytic domain, score 4e-22 218491015737 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491015738 HMMPfam hit to PF02868, DE Thermolysin metallopeptidase, alpha-helical domain, score 1.1e-35 218491015739 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 218491015740 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218491015741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491015742 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.027 218491015743 PS00041 Bacterial regulatory proteins, araC family signature. 218491015744 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.001 218491015745 Predicted helix-turn-helix motif with score 1655.000, SD 4.82 at aa 204-225, sequence IRIQELASAAGMSVSVFHQYFR 218491015746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491015747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 218491015748 NAD(P) binding site [chemical binding]; other site 218491015749 active site 218491015750 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 1.9e-56 218491015751 PS00061 Short-chain dehydrogenases/reductases family signature. 218491015752 Predicted permeases [General function prediction only]; Region: COG0679 218491015753 10 probable transmembrane helices predicted for ECA3215 by TMHMM2.0 at aa 4-26, 39-61, 71-93, 100-122, 132-154, 167-189, 204-223, 235-257, 262-279 and 291-313 218491015754 HMMPfam hit to PF03547, DE Auxin Efflux Carrier, score 8.7e-05 218491015755 GTP-binding protein Der; Reviewed; Region: PRK00093 218491015756 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 218491015757 G1 box; other site 218491015758 GTP/Mg2+ binding site [chemical binding]; other site 218491015759 Switch I region; other site 218491015760 G2 box; other site 218491015761 Switch II region; other site 218491015762 G3 box; other site 218491015763 G4 box; other site 218491015764 G5 box; other site 218491015765 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 218491015766 G1 box; other site 218491015767 GTP/Mg2+ binding site [chemical binding]; other site 218491015768 Switch I region; other site 218491015769 G2 box; other site 218491015770 G3 box; other site 218491015771 Switch II region; other site 218491015772 G4 box; other site 218491015773 G5 box; other site 218491015774 HMMPfam hit to PF01926, DE GTPase of unknown function, score 2.9e-51 218491015775 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015776 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015777 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 218491015778 Signal peptide predicted for ECA3217 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.618 between residues 24 and 25; signal peptide 218491015779 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 218491015780 Trp docking motif [polypeptide binding]; other site 218491015781 HMMPfam hit to PF01011, DE PQQ enzyme repeat, score 0.0023 218491015782 HMMPfam hit to PF01011, DE PQQ enzyme repeat, score 0.29 218491015783 HMMPfam hit to PF01011, DE PQQ enzyme repeat, score 0.002 218491015784 HMMPfam hit to PF01011, DE PQQ enzyme repeat, score 7.3e-07 218491015785 HMMPfam hit to PF01011, DE PQQ enzyme repeat, score 0.00034 218491015786 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491015787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 218491015788 1 probable transmembrane helix predicted for ECA3218 by TMHMM2.0 at aa 21-43 218491015789 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 218491015790 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 218491015791 dimer interface [polypeptide binding]; other site 218491015792 motif 1; other site 218491015793 active site 218491015794 motif 2; other site 218491015795 motif 3; other site 218491015796 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 218491015797 anticodon binding site; other site 218491015798 HMMPfam hit to PF03129, DE Anticodon binding domain, score 9.2e-17 218491015799 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491015800 HMMPfam hit to PF00587, DE tRNA synthetase class II core domain (G, H, P, S and T), score 5.5e-46 218491015801 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 218491015802 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 218491015803 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 218491015804 cytoskeletal protein RodZ; Provisional; Region: PRK10856 218491015805 Helix-turn-helix domain; Region: HTH_25; pfam13413 218491015806 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 218491015807 1 probable transmembrane helix predicted for ECA3221 by TMHMM2.0 at aa 111-133 218491015808 HMMPfam hit to PF01381, DE Helix-turn-helix, score 0.0013 218491015809 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 28-49, sequence LTQQTIAERLCLKITTVRDIED 218491015810 Predicted helix-turn-helix motif with score 1312.000, SD 3.66 at aa 17-38, sequence ERLREARERLGLTQQTIAERLC 218491015811 Predicted helix-turn-helix motif with score 1312.000, SD 3.66 at aa 28-38, sequence LTQQTIAERLC 218491015812 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 218491015813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491015814 binding surface 218491015815 TPR motif; other site 218491015816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491015817 binding surface 218491015818 TPR motif; other site 218491015819 HMMPfam hit to PF00515, DE TPR Domain, score 0.007 218491015820 HMMPfam hit to PF00515, DE TPR Domain, score 0.00089 218491015821 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 218491015822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491015823 FeS/SAM binding site; other site 218491015824 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 218491015825 active site 218491015826 multimer interface [polypeptide binding]; other site 218491015827 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00334, DE Nucleoside diphosphate kinase, score 6e-82 218491015828 PS00469 Nucleoside diphosphate kinases active site. 218491015829 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 218491015830 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491015831 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491015832 active site turn [active] 218491015833 phosphorylation site [posttranslational modification] 218491015834 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015835 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 1.6e-94 218491015836 8 probable transmembrane helices predicted for ECA3225 by TMHMM2.0 at aa 13-35, 64-83, 90-112, 132-154, 167-189, 199-221, 343-365 and 385-407 218491015837 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 1.2e-09 218491015838 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491015839 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 218491015840 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 218491015841 NAD binding site [chemical binding]; other site 218491015842 sugar binding site [chemical binding]; other site 218491015843 divalent metal binding site [ion binding]; other site 218491015844 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 218491015845 dimer interface [polypeptide binding]; other site 218491015846 HMMPfam hit to PF02056, DE Family 4 glycosyl hydrolase, score 1.2e-130 218491015847 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 218491015848 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 218491015849 active site residue [active] 218491015850 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 218491015851 active site residue [active] 218491015852 HMMPfam hit to PF00581, DE Rhodanese-like domain, score 6.3e-29 218491015853 PS00380 Rhodanese signature 1. 218491015854 HMMPfam hit to PF00581, DE Rhodanese-like domain, score 8.9e-26 218491015855 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218491015856 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 218491015857 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218491015858 putative active site [active] 218491015859 HMMPfam hit to PF01418, DE Helix-turn-helix domain, rpiR family, score 3.9e-06 218491015860 Predicted helix-turn-helix motif with score 1533.000, SD 4.41 at aa 36-57, sequence ITVRELAQKTYVSTATIMRLCQ 218491015861 PS00356 Bacterial regulatory proteins, lacI family signature. 218491015862 HMMPfam hit to PF01380, DE SIS domain, score 0.0021 218491015863 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 218491015864 aminopeptidase B; Provisional; Region: PRK05015 218491015865 Peptidase; Region: DUF3663; pfam12404 218491015866 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 218491015867 interface (dimer of trimers) [polypeptide binding]; other site 218491015868 Substrate-binding/catalytic site; other site 218491015869 Zn-binding sites [ion binding]; other site 218491015870 HMMPfam hit to PF00883, DE Cytosol aminopeptidase family, catalytic domain, score 2e-159 218491015871 PS00631 Cytosol aminopeptidase signature. 218491015872 hypothetical protein; Provisional; Region: PRK10721 218491015873 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 218491015874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218491015875 catalytic loop [active] 218491015876 iron binding site [ion binding]; other site 218491015877 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 2.6e-13 218491015878 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 218491015879 chaperone protein HscA; Provisional; Region: hscA; PRK05183 218491015880 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 218491015881 nucleotide binding site [chemical binding]; other site 218491015882 putative NEF/HSP70 interaction site [polypeptide binding]; other site 218491015883 SBD interface [polypeptide binding]; other site 218491015884 HMMPfam hit to PF00012, DE Hsp70 protein, score 5.1e-258 218491015885 PS01036 Heat shock hsp70 proteins family signature 3. 218491015886 PS00329 Heat shock hsp70 proteins family signature 2. 218491015887 PS00297 Heat shock hsp70 proteins family signature 1. 218491015888 co-chaperone HscB; Provisional; Region: hscB; PRK05014 218491015889 DnaJ domain; Region: DnaJ; pfam00226 218491015890 HSP70 interaction site [polypeptide binding]; other site 218491015891 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 218491015892 HMMPfam hit to PF00226, DE DnaJ domain, score 4.4e-07 218491015893 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 218491015894 HMMPfam hit to PF01521, DE HesB-like domain, score 7e-52 218491015895 PS01152 Hypothetical hesB/yadR/yfhF family signature. 218491015896 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 218491015897 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 218491015898 trimerization site [polypeptide binding]; other site 218491015899 active site 218491015900 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01592, DE NifU-like N terminal domain, score 4.6e-81 218491015901 cysteine desulfurase; Provisional; Region: PRK14012 218491015902 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 218491015903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491015904 catalytic residue [active] 218491015905 HMMPfam hit to PF00266, DE Aminotransferase class-V, score 3.7e-124 218491015906 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218491015907 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 218491015908 Rrf2 family protein; Region: rrf2_super; TIGR00738 218491015909 HMMPfam hit to PF02082, DE Transcriptional regulator, score 1.4e-66 218491015910 PS01332 Uncharacterized protein family UPF0074 signature. 218491015911 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 26-47, sequence VPLADISERQGISLSYLEQLFS 218491015912 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 218491015913 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218491015914 HMMPfam hit to PF00588, DE SpoU rRNA Methylase family, score 3.7e-29 218491015915 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 218491015916 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 218491015917 active site 218491015918 dimerization interface [polypeptide binding]; other site 218491015919 HMMPfam hit to PF00459, DE Inositol monophosphatase family, score 1e-105 218491015920 PS00629 Inositol monophosphatase family signature 1. 218491015921 PS00630 Inositol monophosphatase family signature 2. 218491015922 Signal peptide predicted for ECA3241 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.824 between residues 23 and 24; signal peptide 218491015923 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 218491015924 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 218491015925 intersubunit interface [polypeptide binding]; other site 218491015926 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 1.4e-05 218491015927 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491015928 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491015929 ABC-ATPase subunit interface; other site 218491015930 dimer interface [polypeptide binding]; other site 218491015931 putative PBP binding regions; other site 218491015932 9 probable transmembrane helices predicted for ECA3242 by TMHMM2.0 at aa 30-52, 82-104, 116-138, 143-162, 175-197, 217-239, 269-291, 306-325 and 332-354 218491015933 HMMPfam hit to PF01032, DE FecCD transport family, score 8.9e-86 218491015934 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218491015935 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491015936 Walker A/P-loop; other site 218491015937 ATP binding site [chemical binding]; other site 218491015938 Q-loop/lid; other site 218491015939 ABC transporter signature motif; other site 218491015940 Walker B; other site 218491015941 D-loop; other site 218491015942 H-loop/switch region; other site 218491015943 HMMPfam hit to PF00005, DE ABC transporter, score 6e-47 218491015944 PS00017 ATP/GTP-binding site motif A (P-loop). 218491015945 PS00211 ABC transporters family signature. 218491015946 Signal peptide predicted for ECA3245 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.517 between residues 30 and 31; signal peptide 218491015947 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491015948 HAMP domain; Region: HAMP; pfam00672 218491015949 dimerization interface [polypeptide binding]; other site 218491015950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491015951 dimer interface [polypeptide binding]; other site 218491015952 putative CheW interface [polypeptide binding]; other site 218491015953 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 8.4e-93 218491015954 HMMPfam hit to PF00672, DE HAMP domain, score 1.5e-09 218491015955 2 probable transmembrane helices predicted for ECA3245 by TMHMM2.0 at aa 10-32 and 187-209 218491015956 Signal peptide predicted for ECA3246 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.605 between residues 22 and 23; signal peptide 218491015957 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 218491015958 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 218491015959 putative ligand binding residues [chemical binding]; other site 218491015960 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 2.9e-06 218491015961 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 218491015962 7 probable transmembrane helices predicted for ECA3247 by TMHMM2.0 at aa 21-43, 83-105, 118-140, 160-182, 258-280, 284-306 and 327-349 218491015963 Signal peptide predicted for ECA3248 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.985 between residues 29 and 30; signal peptide 218491015964 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 218491015965 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 218491015966 HMMPfam hit to PF01306, DE LacY proton/sugar symporter, score 0.0012 218491015967 12 probable transmembrane helices predicted for ECA3249 by TMHMM2.0 at aa 40-62, 72-94, 101-123, 128-150, 163-185, 189-211, 240-262, 267-289, 302-321, 326-348, 361-383 and 387-409 218491015968 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 218491015969 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 218491015970 dimer interface [polypeptide binding]; other site 218491015971 active site 218491015972 glycine-pyridoxal phosphate binding site [chemical binding]; other site 218491015973 folate binding site [chemical binding]; other site 218491015974 HMMPfam hit to PF00464, DE Serine hydroxymethyltransferase, score 7.4e-279 218491015975 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 218491015976 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 218491015977 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 218491015978 heme-binding site [chemical binding]; other site 218491015979 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 218491015980 FAD binding pocket [chemical binding]; other site 218491015981 FAD binding motif [chemical binding]; other site 218491015982 phosphate binding motif [ion binding]; other site 218491015983 beta-alpha-beta structure motif; other site 218491015984 NAD binding pocket [chemical binding]; other site 218491015985 Heme binding pocket [chemical binding]; other site 218491015986 HMMPfam hit to PF00042, DE Globin, score 2.4e-26 218491015987 HMMPfam hit to PF00970, DE Oxidoreductase FAD-binding domain, score 5.3e-08 218491015988 HMMPfam hit to PF00175, DE Oxidoreductase NAD-binding domain, score 1.3e-19 218491015989 Signal peptide predicted for ECA3252 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 24 and 25; signal peptide 218491015990 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 218491015991 active site 218491015992 catalytic triad [active] 218491015993 HMMPfam hit to PF00657, DE GDSL-like Lipase/Acylhydrolase, score 0.037 218491015994 Signal peptide predicted for ECA3253 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.799 between residues 26 and 27; signal peptide 218491015995 putative pectinesterase; Region: PLN02432; cl01911 218491015996 Pectinesterase; Region: Pectinesterase; pfam01095 218491015997 HMMPfam hit to PF01095, DE Pectinesterase, score 2.1e-146 218491015998 PS00503 Pectinesterase signature 2. 218491015999 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 218491016000 Nitrogen regulatory protein P-II; Region: P-II; smart00938 218491016001 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00543, DE Nitrogen regulatory protein P-II, score 6.7e-61 218491016002 PS00638 P-II protein C-terminal region signature. 218491016003 PS00496 P-II protein urydylation site. 218491016004 response regulator GlrR; Provisional; Region: PRK15115 218491016005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491016006 active site 218491016007 phosphorylation site [posttranslational modification] 218491016008 intermolecular recognition site; other site 218491016009 dimerization interface [polypeptide binding]; other site 218491016010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491016011 Walker A motif; other site 218491016012 ATP binding site [chemical binding]; other site 218491016013 Walker B motif; other site 218491016014 arginine finger; other site 218491016015 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491016016 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 5.1e-143 218491016017 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491016018 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491016019 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 6e-41 218491016020 Signal peptide predicted for ECA3256 by SignalP 2.0 HMM (Signal peptide probabilty 0.924) with cleavage site probability 0.437 between residues 39 and 40; signal peptide 218491016021 hypothetical protein; Provisional; Region: PRK10722 218491016022 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016023 Signal peptide predicted for ECA3257 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.824 between residues 33 and 34; signal peptide 218491016024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218491016025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491016026 dimer interface [polypeptide binding]; other site 218491016027 phosphorylation site [posttranslational modification] 218491016028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491016029 ATP binding site [chemical binding]; other site 218491016030 Mg2+ binding site [ion binding]; other site 218491016031 G-X-G motif; other site 218491016032 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 4e-26 218491016033 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 9.1e-18 218491016034 HMMPfam hit to PF00672, DE HAMP domain, score 7.5e-07 218491016035 2 probable transmembrane helices predicted for ECA3257 by TMHMM2.0 at aa 15-34 and 178-200 218491016036 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 218491016037 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 218491016038 dimerization interface [polypeptide binding]; other site 218491016039 ATP binding site [chemical binding]; other site 218491016040 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 218491016041 dimerization interface [polypeptide binding]; other site 218491016042 ATP binding site [chemical binding]; other site 218491016043 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 218491016044 putative active site [active] 218491016045 catalytic triad [active] 218491016046 HMMPfam hit to PF02769, DE AIR synthase related protein, C-terminal domain, score 1.4e-19 218491016047 HMMPfam hit to PF02769, DE AIR synthase related protein, C-terminal domain, score 1.3e-35 218491016048 HMMPfam hit to PF00586, DE AIR synthase related protein, N-terminal domain, score 5.6e-27 218491016049 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 218491016050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491016051 substrate binding pocket [chemical binding]; other site 218491016052 membrane-bound complex binding site; other site 218491016053 hinge residues; other site 218491016054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491016055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491016056 catalytic residue [active] 218491016057 1 probable transmembrane helix predicted for ECA3259 by TMHMM2.0 at aa 42-64 218491016058 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 8.1e-34 218491016059 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218491016060 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 4.9e-37 218491016061 PS00922 Prokaryotic transglycosylases signature. 218491016062 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 218491016063 nucleoside/Zn binding site; other site 218491016064 dimer interface [polypeptide binding]; other site 218491016065 catalytic motif [active] 218491016066 HMMPfam hit to PF00383, DE Cytidine and deoxycytidylate deaminase zinc-binding region, score 9.3e-41 218491016067 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218491016068 hypothetical protein; Provisional; Region: PRK11590 218491016069 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 218491016070 1 probable transmembrane helix predicted for ECA3261 by TMHMM2.0 at aa 35-57 218491016071 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 218491016072 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 218491016073 putative active site [active] 218491016074 HMMPfam hit to PF01380, DE SIS domain, score 3e-06 218491016075 PS01272 Glucokinase regulatory protein family signature. 218491016076 Signal peptide predicted for ECA3263 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.795 between residues 29 and 30; signal peptide 218491016077 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 218491016078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016079 Signal peptide predicted for ECA3264 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.663 between residues 25 and 26; signal peptide 218491016080 HAMP domain; Region: HAMP; pfam00672 218491016081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491016082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491016083 metal binding site [ion binding]; metal-binding site 218491016084 active site 218491016085 I-site; other site 218491016086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491016087 2 probable transmembrane helices predicted for ECA3264 by TMHMM2.0 at aa 5-27 and 148-170 218491016088 HMMPfam hit to PF00672, DE HAMP domain, score 1.4e-08 218491016089 HMMPfam hit to PF00990, DE GGDEF domain, score 8.4e-08 218491016090 HMMPfam hit to PF00563, DE EAL domain, score 1.2e-17 218491016091 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491016092 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491016093 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491016094 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491016095 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491016096 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 218491016097 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 218491016098 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 47 218491016099 PS00330 Hemolysin-type calcium-binding region signature. 218491016100 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 0.0017 218491016101 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 0.00024 218491016102 PS00330 Hemolysin-type calcium-binding region signature. 218491016103 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 0.13 218491016104 HMMPfam hit to PF00353, DE Hemolysin-type calcium-binding repeat (2 copies), score 7.4 218491016105 PS00177 DNA topoisomerase II signature. 218491016106 Signal peptide predicted for ECA3267 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23; signal peptide 218491016107 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 218491016108 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 2.5e-27 218491016109 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 5.3e-29 218491016110 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 218491016111 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 218491016112 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218491016113 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 218491016114 Walker A/P-loop; other site 218491016115 ATP binding site [chemical binding]; other site 218491016116 Q-loop/lid; other site 218491016117 ABC transporter signature motif; other site 218491016118 Walker B; other site 218491016119 D-loop; other site 218491016120 H-loop/switch region; other site 218491016121 4 probable transmembrane helices predicted for ECA3268 by TMHMM2.0 at aa 186-208, 223-242, 314-336 and 423-445 218491016122 HMMPfam hit to PF00664, DE ABC transporter transmembrane region, score 0.00062 218491016123 HMMPfam hit to PF00005, DE ABC transporter, score 2.6e-58 218491016124 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016125 PS00211 ABC transporters family signature. 218491016126 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218491016127 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491016128 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491016129 1 probable transmembrane helix predicted for ECA3269 by TMHMM2.0 at aa 39-61 218491016130 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 4.8e-20 218491016131 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491016132 PS00543 HlyD family secretion proteins signature. 218491016133 Signal peptide predicted for ECA3270 by SignalP 2.0 HMM (Signal peptide probabilty 0.684) with cleavage site probability 0.498 between residues 21 and 22; signal peptide 218491016134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491016135 PAS domain; Region: PAS_9; pfam13426 218491016136 putative active site [active] 218491016137 heme pocket [chemical binding]; other site 218491016138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 218491016139 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 218491016140 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491016141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491016142 metal binding site [ion binding]; metal-binding site 218491016143 active site 218491016144 I-site; other site 218491016145 HMMPfam hit to PF00990, DE GGDEF domain, score 4.6e-56 218491016146 HMMPfam hit to PF01590, DE GAF domain, score 3.1e-07 218491016147 HMMPfam hit to PF00785, DE PAC motif, score 1.7e-07 218491016148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491016149 HMMPfam hit to PF00563, DE EAL domain, score 3.6e-12 218491016150 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 218491016151 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00027 218491016152 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491016153 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 218491016154 HMMPfam hit to PF01648, DE 4'-phosphopantetheinyl transferase superfamily, score 7.8e-39 218491016155 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 218491016156 active site 218491016157 hydrophilic channel; other site 218491016158 dimerization interface [polypeptide binding]; other site 218491016159 catalytic residues [active] 218491016160 active site lid [active] 218491016161 HMMPfam hit to PF03740, DE Pyridoxal phosphate biosynthesis protein PdxJ, score 1.4e-144 218491016162 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 218491016163 Recombination protein O N terminal; Region: RecO_N; pfam11967 218491016164 Recombination protein O C terminal; Region: RecO_C; pfam02565 218491016165 HMMPfam hit to PF02565, DE Recombination protein O, score 5.3e-86 218491016166 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491016167 GTPase Era; Reviewed; Region: era; PRK00089 218491016168 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 218491016169 G1 box; other site 218491016170 GTP/Mg2+ binding site [chemical binding]; other site 218491016171 Switch I region; other site 218491016172 G2 box; other site 218491016173 Switch II region; other site 218491016174 G3 box; other site 218491016175 G4 box; other site 218491016176 G5 box; other site 218491016177 KH domain; Region: KH_2; pfam07650 218491016178 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016179 ribonuclease III; Reviewed; Region: rnc; PRK00102 218491016180 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 218491016181 dimerization interface [polypeptide binding]; other site 218491016182 active site 218491016183 metal binding site [ion binding]; metal-binding site 218491016184 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 218491016185 dsRNA binding site [nucleotide binding]; other site 218491016186 HMMPfam hit to PF00035, DE Double-stranded RNA binding motif, score 4.8e-23 218491016187 HMMPfam hit to PF00636, DE RNase3 domain, score 2.2e-47 218491016188 PS00517 Ribonuclease III family signature. 218491016189 signal peptidase I; Provisional; Region: PRK10861 218491016190 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218491016191 Catalytic site [active] 218491016192 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218491016193 HMMPfam hit to PF00461, DE Signal peptidase I, score 1.8e-86 218491016194 PS00761 Signal peptidases I signature 3. 218491016195 PS00760 Signal peptidases I lysine active site. 218491016196 PS00501 Signal peptidases I serine active site. 218491016197 2 probable transmembrane helices predicted for ECA3279 by TMHMM2.0 at aa 5-27 and 58-80 218491016198 GTP-binding protein LepA; Provisional; Region: PRK05433 218491016199 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 218491016200 G1 box; other site 218491016201 putative GEF interaction site [polypeptide binding]; other site 218491016202 GTP/Mg2+ binding site [chemical binding]; other site 218491016203 Switch I region; other site 218491016204 G2 box; other site 218491016205 G3 box; other site 218491016206 Switch II region; other site 218491016207 G4 box; other site 218491016208 G5 box; other site 218491016209 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 218491016210 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 218491016211 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 218491016212 HMMPfam hit to PF00679, DE Elongation factor G C-terminus, score 1.4e-31 218491016213 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 3.2e-12 218491016214 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 5.5e-74 218491016215 PS00301 GTP-binding elongation factors signature. 218491016216 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016217 SoxR reducing system protein RseC; Provisional; Region: PRK10862 218491016218 2 probable transmembrane helices predicted for ECA3281 by TMHMM2.0 at aa 73-95 and 99-121 218491016219 anti-sigma E factor; Provisional; Region: rseB; PRK09455 218491016220 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 218491016221 Signal peptide predicted for ECA3282 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.683 between residues 23 and 24; signal peptide 218491016222 HMMPfam hit to PF03888, DE MucB/RseB family, score 4.2e-128 218491016223 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 218491016224 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 218491016225 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 218491016226 HMMPfam hit to PF03873, DE Anti sigma-E protein RseA, C-terminal domain, score 4.3e-11 218491016227 HMMPfam hit to PF03872, DE Anti sigma-E protein RseA, N-terminal domain, score 7.6e-39 218491016228 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 218491016229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491016230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491016231 DNA binding residues [nucleotide binding] 218491016232 Predicted helix-turn-helix motif with score 1031.000, SD 2.70 at aa 154-175, sequence LSYEEIAVIMDCPVGTVRSRIF 218491016233 HMMPfam hit to PF00776, , score 5.7e-26 218491016234 PS01063 Sigma-70 factors ECF subfamily signature. 218491016235 L-aspartate oxidase; Provisional; Region: PRK09077 218491016236 L-aspartate oxidase; Provisional; Region: PRK06175 218491016237 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218491016238 HMMPfam hit to PF00890, DE FAD binding domain, score 9.3e-161 218491016239 HMMPfam hit to PF02910, DE Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain, score 4.4e-10 218491016240 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 218491016241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491016242 S-adenosylmethionine binding site [chemical binding]; other site 218491016243 PS00092 N-6 Adenine-specific DNA methylases signature. 218491016244 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 218491016245 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218491016246 ATP binding site [chemical binding]; other site 218491016247 Mg++ binding site [ion binding]; other site 218491016248 motif III; other site 218491016249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491016250 nucleotide binding region [chemical binding]; other site 218491016251 ATP-binding site [chemical binding]; other site 218491016252 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 2e-78 218491016253 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016254 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491016255 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 1.9e-29 218491016256 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 218491016257 HMMPfam hit to PF01228, DE Glycine radical, score 4.6e-43 218491016258 PS00850 Glycine radical signature. 218491016259 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 218491016260 ligand binding site [chemical binding]; other site 218491016261 active site 218491016262 UGI interface [polypeptide binding]; other site 218491016263 catalytic site [active] 218491016264 HMMPfam hit to PF03167, DE Uracil DNA glycosylase superfamily, score 5.8e-86 218491016265 PS00130 Uracil-DNA glycosylase signature. 218491016266 Signal peptide predicted for ECA3290 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 23 and 24; signal peptide 218491016267 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 218491016268 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 218491016269 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218491016270 active site 218491016271 HIGH motif; other site 218491016272 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218491016273 active site 218491016274 KMSKS motif; other site 218491016275 Predicted helix-turn-helix motif with score 1031.000, SD 2.70 at aa 390-411, sequence LVREKLAAITSWTAENIHHAIQ 218491016276 HMMPfam hit to PF00749, DE tRNA synthetases class I (E and Q), catalytic domain, score 2.9e-174 218491016277 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491016278 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 218491016279 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 218491016280 putative active site [active] 218491016281 putative FMN binding site [chemical binding]; other site 218491016282 putative substrate binding site [chemical binding]; other site 218491016283 putative catalytic residue [active] 218491016284 HMMPfam hit to PF00724, DE NADH:flavin oxidoreductase / NADH oxidase family, score 2.8e-74 218491016285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218491016286 active site 218491016287 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218491016288 catalytic tetrad [active] 218491016289 HMMPfam hit to PF00248, DE Aldo/keto reductase family, score 8.3e-43 218491016290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491016291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491016292 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 3.3e-11 218491016293 PS01081 Bacterial regulatory proteins, tetR family signature. 218491016294 DoxX; Region: DoxX; pfam07681 218491016295 4 probable transmembrane helices predicted for ECA3295 by TMHMM2.0 at aa 48-65, 85-107, 112-134 and 144-166 218491016296 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 218491016297 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 218491016298 Walker A/P-loop; other site 218491016299 ATP binding site [chemical binding]; other site 218491016300 Q-loop/lid; other site 218491016301 ABC transporter signature motif; other site 218491016302 Walker B; other site 218491016303 D-loop; other site 218491016304 H-loop/switch region; other site 218491016305 TOBE-like domain; Region: TOBE_3; pfam12857 218491016306 HMMPfam hit to PF00005, DE ABC transporter, score 9.2e-71 218491016307 PS00211 ABC transporters family signature. 218491016308 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016309 sulfate transport protein; Provisional; Region: cysT; CHL00187 218491016310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491016311 dimer interface [polypeptide binding]; other site 218491016312 conserved gate region; other site 218491016313 putative PBP binding loops; other site 218491016314 ABC-ATPase subunit interface; other site 218491016315 6 probable transmembrane helices predicted for ECA3297 by TMHMM2.0 at aa 21-43, 71-93, 105-127, 142-164, 206-228 and 248-270 218491016316 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 8.3e-07 218491016317 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491016318 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 218491016319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491016320 dimer interface [polypeptide binding]; other site 218491016321 conserved gate region; other site 218491016322 putative PBP binding loops; other site 218491016323 ABC-ATPase subunit interface; other site 218491016324 7 probable transmembrane helices predicted for ECA3298 by TMHMM2.0 at aa 15-37, 61-83, 103-125, 132-154, 179-201, 208-230 and 240-262 218491016325 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9.6e-15 218491016326 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491016327 Signal peptide predicted for ECA3299 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 23 and 24; signal peptide 218491016328 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 218491016329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491016330 substrate binding pocket [chemical binding]; other site 218491016331 membrane-bound complex binding site; other site 218491016332 hinge residues; other site 218491016333 HMMPfam hit to PF01100, , score 8.4e-173 218491016334 PS00757 Prokaryotic sulfate-binding proteins signature 2. 218491016335 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 218491016336 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 218491016337 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 218491016338 Signal peptide predicted for ECA3301 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.988 between residues 26 and 27; signal peptide 218491016339 serine endoprotease; Provisional; Region: PRK10942 218491016340 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218491016341 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218491016342 protein binding site [polypeptide binding]; other site 218491016343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218491016344 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 4.3e-13 218491016345 HMMPfam hit to PF00595, DE PDZ domain (Also known as DHR or GLGF), score 1.4e-18 218491016346 HMMPfam hit to PF00089, DE Trypsin, score 1.2e-25 218491016347 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 218491016348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218491016349 Zn2+ binding site [ion binding]; other site 218491016350 Mg2+ binding site [ion binding]; other site 218491016351 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 218491016352 HMMPfam hit to PF01966, DE HD domain, score 0.00038 218491016353 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 218491016354 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 218491016355 HMMPfam hit to PF01048, DE Phosphorylase family, score 1.4e-96 218491016356 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 218491016357 Signal peptide predicted for ECA3304 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 20 and 21; signal peptide 218491016358 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 218491016359 cobalamin binding residues [chemical binding]; other site 218491016360 putative BtuC binding residues; other site 218491016361 dimer interface [polypeptide binding]; other site 218491016362 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 3.6e-33 218491016363 Signal peptide predicted for ECA3305 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.968 between residues 20 and 21; signal peptide 218491016364 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016365 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 218491016366 HMMPfam hit to PF01521, DE HesB-like domain, score 2.7e-55 218491016367 PS01152 Hypothetical hesB/yadR/yfhF family signature. 218491016368 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 218491016369 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491016370 inhibitor-cofactor binding pocket; inhibition site 218491016371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491016372 catalytic residue [active] 218491016373 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00202, DE Aminotransferase class-III, score 2.5e-115 218491016374 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491016375 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491016376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491016377 DNA-binding site [nucleotide binding]; DNA binding site 218491016378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491016379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491016380 homodimer interface [polypeptide binding]; other site 218491016381 catalytic residue [active] 218491016382 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 3.9e-07 218491016383 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 218491016384 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016385 4 probable transmembrane helices predicted for ECA3309 by TMHMM2.0 at aa 39-61, 68-85, 134-156 and 169-188 218491016386 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491016387 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491016388 ABC-ATPase subunit interface; other site 218491016389 dimer interface [polypeptide binding]; other site 218491016390 putative PBP binding regions; other site 218491016391 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491016392 ABC-ATPase subunit interface; other site 218491016393 dimer interface [polypeptide binding]; other site 218491016394 putative PBP binding regions; other site 218491016395 HMMPfam hit to PF01032, DE FecCD transport family, score 2.2e-60 218491016396 17 probable transmembrane helices predicted for ECA3310 by TMHMM2.0 at aa 12-34, 67-89, 102-121, 126-148, 155-177, 249-271, 284-302, 312-334, 359-381, 401-423, 436-454, 458-480, 492-511, 537-559, 580-602, 617-636 and 643-665 218491016397 HMMPfam hit to PF01032, DE FecCD transport family, score 7.2e-48 218491016398 Signal peptide predicted for ECA3311 by SignalP 2.0 HMM (Signal peptide probabilty 0.853) with cleavage site probability 0.371 between residues 35 and 36; signal peptide 218491016399 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 218491016400 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 218491016401 siderophore binding site; other site 218491016402 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 8.4e-06 218491016403 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 218491016404 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218491016405 Walker A/P-loop; other site 218491016406 ATP binding site [chemical binding]; other site 218491016407 Q-loop/lid; other site 218491016408 ABC transporter signature motif; other site 218491016409 Walker B; other site 218491016410 D-loop; other site 218491016411 H-loop/switch region; other site 218491016412 HMMPfam hit to PF00005, DE ABC transporter, score 2.3e-51 218491016413 PS00211 ABC transporters family signature. 218491016414 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016415 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 218491016416 Transglycosylase; Region: Transgly; pfam00912 218491016417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218491016418 HMMPfam hit to PF00905, DE Penicillin binding protein transpeptidase domain, score 4.6e-11 218491016419 HMMPfam hit to PF00912, DE Transglycosylase, score 1.5e-96 218491016420 1 probable transmembrane helix predicted for ECA3313 by TMHMM2.0 at aa 67-89 218491016421 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 218491016422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491016423 ATP binding site [chemical binding]; other site 218491016424 putative Mg++ binding site [ion binding]; other site 218491016425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491016426 nucleotide binding region [chemical binding]; other site 218491016427 ATP-binding site [chemical binding]; other site 218491016428 Helicase associated domain (HA2); Region: HA2; pfam04408 218491016429 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 218491016430 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 1.5e-11 218491016431 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016432 2'-5' RNA ligase; Provisional; Region: PRK15124 218491016433 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 218491016434 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 218491016435 HMMPfam hit to PF02834, DE 2',5' RNA ligase family, score 1.2e-13 218491016436 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 218491016437 HMMPfam hit to PF03749, DE Sugar fermentation stimulation protein, score 2.2e-100 218491016438 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 218491016439 HMMPfam hit to PF01258, DE Prokaryotic dksA/traR C4-type zinc finger, score 9e-34 218491016440 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 218491016441 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 218491016442 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 218491016443 active site 218491016444 nucleotide binding site [chemical binding]; other site 218491016445 HIGH motif; other site 218491016446 KMSKS motif; other site 218491016447 HMMPfam hit to PF00749, DE tRNA synthetases class I (E and Q), catalytic domain, score 7.4e-19 218491016448 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 218491016449 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218491016450 active site 218491016451 NTP binding site [chemical binding]; other site 218491016452 metal binding triad [ion binding]; metal-binding site 218491016453 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218491016454 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 218491016455 HMMPfam hit to PF01743, DE Poly A polymerase family, score 7.7e-68 218491016456 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 218491016457 catalytic center binding site [active] 218491016458 ATP binding site [chemical binding]; other site 218491016459 HMMPfam hit to PF01288, DE 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 1.9e-70 218491016460 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 218491016461 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 218491016462 oligomerization interface [polypeptide binding]; other site 218491016463 active site 218491016464 metal binding site [ion binding]; metal-binding site 218491016465 HMMPfam hit to PF02548, DE Ketopantoate hydroxymethyltransferase, score 1.1e-161 218491016466 Pantoate-beta-alanine ligase; Region: PanC; cd00560 218491016467 pantoate--beta-alanine ligase; Region: panC; TIGR00018 218491016468 active site 218491016469 ATP-binding site [chemical binding]; other site 218491016470 pantoate-binding site; other site 218491016471 HXXH motif; other site 218491016472 HMMPfam hit to PF02569, DE Pantoate-beta-alanine ligase, score 3.6e-144 218491016473 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 218491016474 tetramerization interface [polypeptide binding]; other site 218491016475 active site 218491016476 HMMPfam hit to PF02261, DE Aspartate decarboxylase, score 9.4e-80 218491016477 inner membrane transport permease; Provisional; Region: PRK15066 218491016478 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 218491016479 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01061, DE ABC-2 type transporter, score 0.00015 218491016480 6 probable transmembrane helices predicted for ECA3324 by TMHMM2.0 at aa 20-42, 62-84, 105-127, 137-159, 172-194 and 226-248 218491016481 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218491016482 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 218491016483 Walker A/P-loop; other site 218491016484 ATP binding site [chemical binding]; other site 218491016485 Q-loop/lid; other site 218491016486 ABC transporter signature motif; other site 218491016487 Walker B; other site 218491016488 D-loop; other site 218491016489 H-loop/switch region; other site 218491016490 HMMPfam hit to PF00005, DE ABC transporter, score 1.4e-52 218491016491 PS00211 ABC transporters family signature. 218491016492 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016493 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 218491016494 active site clefts [active] 218491016495 zinc binding site [ion binding]; other site 218491016496 dimer interface [polypeptide binding]; other site 218491016497 HMMPfam hit to PF00484, DE Carbonic anhydrase, score 9.8e-76 218491016498 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 218491016499 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 218491016500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491016501 active site 218491016502 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 2.3e-34 218491016503 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491016504 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218491016505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491016506 Coenzyme A binding pocket [chemical binding]; other site 218491016507 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 4.1e-08 218491016508 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 218491016509 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 218491016510 Walker A/P-loop; other site 218491016511 ATP binding site [chemical binding]; other site 218491016512 Q-loop/lid; other site 218491016513 ABC transporter signature motif; other site 218491016514 Walker B; other site 218491016515 D-loop; other site 218491016516 H-loop/switch region; other site 218491016517 TOBE domain; Region: TOBE_2; pfam08402 218491016518 HMMPfam hit to PF00005, DE ABC transporter, score 6.9e-55 218491016519 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016520 Signal peptide predicted for ECA3331 by SignalP 2.0 HMM (Signal peptide probabilty 0.847) with cleavage site probability 0.690 between residues 20 and 21; signal peptide 218491016521 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 218491016522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491016523 dimer interface [polypeptide binding]; other site 218491016524 conserved gate region; other site 218491016525 putative PBP binding loops; other site 218491016526 ABC-ATPase subunit interface; other site 218491016527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491016528 dimer interface [polypeptide binding]; other site 218491016529 conserved gate region; other site 218491016530 putative PBP binding loops; other site 218491016531 ABC-ATPase subunit interface; other site 218491016532 12 probable transmembrane helices predicted for ECA3331 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 122-144, 170-192, 225-247, 278-300, 320-339, 352-374, 384-406, 457-479 and 499-521 218491016533 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.00014 218491016534 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 9.7e-06 218491016535 Predicted helix-turn-helix motif with score 1055.000, SD 2.78 at aa 154-175, sequence ASLIHSARLLNQTRAQVFRRLC 218491016536 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491016537 Signal peptide predicted for ECA3332 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.368 between residues 20 and 21; signal peptide 218491016538 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 218491016539 spermidine synthase; Provisional; Region: PRK00811 218491016540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491016541 S-adenosylmethionine binding site [chemical binding]; other site 218491016542 HMMPfam hit to PF01564, DE Spermine/spermidine synthase, score 5.6e-128 218491016543 PS01330 Spermidine/spermine synthases family signature. 218491016544 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 218491016545 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 218491016546 catalytic residues [active] 218491016547 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 218491016548 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 218491016549 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 218491016550 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218491016551 active site 218491016552 dimer interface [polypeptide binding]; other site 218491016553 catalytic residues [active] 218491016554 effector binding site; other site 218491016555 R2 peptide binding site; other site 218491016556 HMMPfam hit to PF00317, DE Ribonucleotide reductase, all-alpha domain, score 6.7e-25 218491016557 PS00306 Caseins alpha/beta signature. 218491016558 HMMPfam hit to PF02867, DE Ribonucleotide reductase, barrel domain, score 1.8e-216 218491016559 PS00089 Ribonucleotide reductase large subunit signature. 218491016560 Predicted helix-turn-helix motif with score 1011.000, SD 2.63 at aa 672-693, sequence LFFRDTATTRDINKAQIYAWTK 218491016561 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 218491016562 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218491016563 dimer interface [polypeptide binding]; other site 218491016564 putative radical transfer pathway; other site 218491016565 diiron center [ion binding]; other site 218491016566 tyrosyl radical; other site 218491016567 HMMPfam hit to PF00268, DE Ribonucleotide reductase, small chain, score 6.3e-91 218491016568 PS00368 Ribonucleotide reductase small subunit signature. 218491016569 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 218491016570 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 218491016571 active site 218491016572 catalytic site [active] 218491016573 substrate binding site [chemical binding]; other site 218491016574 HMMPfam hit to PF00929, DE Exonuclease, score 1.7e-46 218491016575 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 218491016576 RNA/DNA hybrid binding site [nucleotide binding]; other site 218491016577 active site 218491016578 HMMPfam hit to PF00075, DE RNase H, score 2.6e-64 218491016579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491016580 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 218491016581 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 8.7e-44 218491016582 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 218491016583 Signal peptide predicted for ECA3343 by SignalP 2.0 HMM (Signal peptide probabilty 0.671) with cleavage site probability 0.369 between residues 24 and 25; signal peptide 218491016584 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491016585 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491016586 catalytic residue [active] 218491016587 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218491016588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218491016589 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016590 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 2.8e-32 218491016591 PS00922 Prokaryotic transglycosylases signature. 218491016592 HMMPfam hit to PF01476, DE LysM domain, score 2.9e-15 218491016593 Predicted helix-turn-helix motif with score 1072.000, SD 2.84 at aa 353-374, sequence DTLSAIATRLNVSTKDLQSWNN 218491016594 Predicted helix-turn-helix motif with score 1072.000, SD 2.84 at aa 407-374, sequence NLRSVGALKVGQTLQVAKASGTNGSITYQVRKGD 218491016595 HMMPfam hit to PF01476, DE LysM domain, score 8e-11 218491016596 Predicted helix-turn-helix motif with score 979.000, SD 2.52 at aa 407-428, sequence DSLASIAKRHGVNIADVMRWNT 218491016597 hypothetical protein; Provisional; Region: PRK05421 218491016598 putative catalytic site [active] 218491016599 putative metal binding site [ion binding]; other site 218491016600 putative catalytic site [active] 218491016601 putative phosphate binding site [ion binding]; other site 218491016602 putative phosphate binding site [ion binding]; other site 218491016603 putative metal binding site [ion binding]; other site 218491016604 HMMPfam hit to PF03372, DE Endonuclease/Exonuclease/phosphatase family, score 1e-10 218491016605 protein disaggregation chaperone; Provisional; Region: PRK10865 218491016606 Clp amino terminal domain; Region: Clp_N; pfam02861 218491016607 Clp amino terminal domain; Region: Clp_N; pfam02861 218491016608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491016609 Walker A motif; other site 218491016610 ATP binding site [chemical binding]; other site 218491016611 Walker B motif; other site 218491016612 arginine finger; other site 218491016613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491016614 Walker A motif; other site 218491016615 ATP binding site [chemical binding]; other site 218491016616 Walker B motif; other site 218491016617 arginine finger; other site 218491016618 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218491016619 PS00871 Chaperonins clpA/B signature 2. 218491016620 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016621 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016622 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 2.1e-10 218491016623 PS00870 Chaperonins clpA/B signature 1. 218491016624 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016625 HMMPfam hit to PF02861, DE Clp amino terminal domain, score 1.4e-12 218491016626 Predicted helix-turn-helix motif with score 1155.000, SD 3.12 at aa 120-141, sequence GTLGDILKKAGVTQQGVTNAID 218491016627 HMMPfam hit to PF02861, DE Clp amino terminal domain, score 4.5e-08 218491016628 hypothetical protein; Provisional; Region: PRK10723 218491016629 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 218491016630 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02578, DE Uncharacterised ACR, YfiH family COG1496, score 4.9e-81 218491016631 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 218491016632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491016633 RNA binding surface [nucleotide binding]; other site 218491016634 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218491016635 active site 218491016636 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 8.1e-67 218491016637 PS01129 Rlu family of pseudouridine synthase signature. 218491016638 HMMPfam hit to PF01479, DE S4 domain, score 6.3e-11 218491016639 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 218491016640 Signal peptide predicted for ECA3348 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.818 between residues 24 and 25; signal peptide 218491016641 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03696, DE Uncharacterised protein family (UPF0169), score 4.4e-127 218491016642 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016643 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 218491016644 30S subunit binding site; other site 218491016645 HMMPfam hit to PF02482, DE Sigma 54 modulation protein / S30EA ribosomal protein, score 5.1e-45 218491016646 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 218491016647 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 218491016648 Prephenate dehydratase; Region: PDT; pfam00800 218491016649 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 218491016650 putative L-Phe binding site [chemical binding]; other site 218491016651 HMMPfam hit to PF01817, DE Chorismate mutase, score 1.7e-24 218491016652 HMMPfam hit to PF00800, DE Prephenate dehydratase, score 8.5e-95 218491016653 PS00857 Prephenate dehydratase signature 1. 218491016654 PS00858 Prephenate dehydratase signature 2. 218491016655 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 218491016656 Chorismate mutase type II; Region: CM_2; cl00693 218491016657 prephenate dehydrogenase; Validated; Region: PRK08507 218491016658 HMMPfam hit to PF02153, DE Prephenate dehydrogenase, score 1.6e-12 218491016659 HMMPfam hit to PF01817, DE Chorismate mutase, score 6.1e-23 218491016660 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 218491016661 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218491016662 HMMPfam hit to PF00793, DE DAHP synthetase I family, score 8.6e-159 218491016663 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 218491016664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491016665 active site 218491016666 phosphorylation site [posttranslational modification] 218491016667 intermolecular recognition site; other site 218491016668 dimerization interface [polypeptide binding]; other site 218491016669 LytTr DNA-binding domain; Region: LytTR; pfam04397 218491016670 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.1e-33 218491016671 lipoprotein; Provisional; Region: PRK11443 218491016672 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 218491016673 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491016675 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 218491016676 HMMPfam hit to PF01245, DE Ribosomal protein L19, score 5.1e-76 218491016677 PS01015 Ribosomal protein L19 signature. 218491016678 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 218491016679 HMMPfam hit to PF01746, DE tRNA (Guanine-1)-methyltransferase, score 8.6e-138 218491016680 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 218491016681 RimM N-terminal domain; Region: RimM; pfam01782 218491016682 PRC-barrel domain; Region: PRC; pfam05239 218491016683 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01782, DE RimM N-terminal domain, score 3.8e-82 218491016684 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 218491016685 HMMPfam hit to PF00886, DE Ribosomal protein S16, score 3.7e-31 218491016686 PS00732 Ribosomal protein S16 signature. 218491016687 signal recognition particle protein; Provisional; Region: PRK10867 218491016688 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 218491016689 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218491016690 P loop; other site 218491016691 GTP binding site [chemical binding]; other site 218491016692 Signal peptide binding domain; Region: SRP_SPB; pfam02978 218491016693 HMMPfam hit to PF02978, DE Signal peptide binding domain, score 6.1e-48 218491016694 HMMPfam hit to PF00448, DE SRP54-type protein, GTPase domain, score 4.8e-120 218491016695 PS00300 SRP54-type proteins GTP-binding domain signature. 218491016696 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491016697 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016698 HMMPfam hit to PF02881, DE SRP54-type protein, helical bundle domain, score 1.7e-32 218491016699 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 218491016700 8 probable transmembrane helices predicted for ECA3361 by TMHMM2.0 at aa 2-24, 28-50, 62-84, 89-111, 123-145, 175-197, 210-227 and 237-254 218491016701 S-ribosylhomocysteinase; Provisional; Region: PRK02260 218491016702 HMMPfam hit to PF02664, DE LuxS protein, score 1.7e-107 218491016703 glutamate--cysteine ligase; Provisional; Region: PRK02107 218491016704 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 218491016705 Predicted membrane protein [Function unknown]; Region: COG1238 218491016706 3 probable transmembrane helices predicted for ECA3364 by TMHMM2.0 at aa 15-37, 57-79 and 89-111 218491016707 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 218491016708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491016709 motif II; other site 218491016710 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 2.3e-28 218491016711 carbon storage regulator; Provisional; Region: PRK01712 218491016712 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02599, DE Global regulator protein family, score 5e-36 218491016713 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 218491016714 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 218491016715 motif 1; other site 218491016716 active site 218491016717 motif 2; other site 218491016718 motif 3; other site 218491016719 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 218491016720 DHHA1 domain; Region: DHHA1; pfam02272 218491016721 HMMPfam hit to PF02272, DE DHHA1 domain, score 4.8e-19 218491016722 HMMPfam hit to PF01411, DE tRNA synthetases class II (A), score 0 218491016723 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491016724 recombination regulator RecX; Reviewed; Region: recX; PRK00117 218491016725 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02631, DE RecX family, score 2.9e-35 218491016726 recombinase A; Provisional; Region: recA; PRK09354 218491016727 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 218491016728 hexamer interface [polypeptide binding]; other site 218491016729 Walker A motif; other site 218491016730 ATP binding site [chemical binding]; other site 218491016731 Walker B motif; other site 218491016732 HMMPfam hit to PF00154, DE recA bacterial DNA recombination protein, score 9.3e-239 218491016733 PS00321 recA signature. 218491016734 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016735 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016736 hypothetical protein; Validated; Region: PRK03661 218491016737 HMMPfam hit to PF02464, DE Competence-damaged protein, score 1e-83 218491016738 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 218491016739 putative hydrophobic ligand binding site [chemical binding]; other site 218491016740 inner membrane protein; Provisional; Region: PRK10995 218491016741 HMMPfam hit to PF01914, DE MarC family integral membrane protein, score 1.5e-73 218491016742 6 probable transmembrane helices predicted for ECA3373 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 120-142, 157-178 and 199-221 218491016743 Signal peptide predicted for ECA3374 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.951 between residues 30 and 31; signal peptide 218491016744 Cache domain; Region: Cache_1; pfam02743 218491016745 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491016746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491016747 metal binding site [ion binding]; metal-binding site 218491016748 active site 218491016749 I-site; other site 218491016750 HMMPfam hit to PF02743, DE Cache domain, score 0.00032 218491016751 HMMPfam hit to PF00990, DE GGDEF domain, score 2e-63 218491016752 Signal peptide predicted for ECA3375 by SignalP 2.0 HMM (Signal peptide probabilty 0.684) with cleavage site probability 0.678 between residues 35 and 36; signal peptide 218491016753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491016754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491016755 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0022 218491016756 12 probable transmembrane helices predicted for ECA3375 by TMHMM2.0 at aa 21-39, 54-76, 89-111, 116-135, 142-164, 174-196, 225-244, 254-276, 283-305, 309-328, 345-367 and 371-393 218491016757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491016758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491016759 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491016760 putative effector binding pocket; other site 218491016761 dimerization interface [polypeptide binding]; other site 218491016762 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.7e-48 218491016763 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1e-18 218491016764 Predicted helix-turn-helix motif with score 1541.000, SD 4.44 at aa 29-50, sequence GSFSAASRRLGIGQPAVSKAIM 218491016765 glutaredoxin 2; Provisional; Region: PRK10387 218491016766 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 218491016767 C-terminal domain interface [polypeptide binding]; other site 218491016768 GSH binding site (G-site) [chemical binding]; other site 218491016769 catalytic residues [active] 218491016770 putative dimer interface [polypeptide binding]; other site 218491016771 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 218491016772 N-terminal domain interface [polypeptide binding]; other site 218491016773 PS00195 Glutaredoxin active site. 218491016774 Signal peptide predicted for ECA3378 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.983 between residues 20 and 21; signal peptide 218491016775 possible genomic island 218491016776 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 218491016777 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 218491016778 active site 218491016779 TDP-binding site; other site 218491016780 acceptor substrate-binding pocket; other site 218491016781 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 218491016782 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 218491016783 substrate binding pocket [chemical binding]; other site 218491016784 active site 218491016785 iron coordination sites [ion binding]; other site 218491016786 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 218491016787 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 218491016788 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 218491016789 RHS protein; Region: RHS; pfam03527 218491016790 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 218491016791 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 218491016792 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491016793 active site 218491016794 DNA binding site [nucleotide binding] 218491016795 Int/Topo IB signature motif; other site 218491016796 HMMPfam hit to PF00589, DE Phage integrase family, score 5.1e-32 218491016797 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 6.7e-06 218491016798 CHC2 zinc finger; Region: zf-CHC2; cl17510 218491016799 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491016800 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218491016801 active site 218491016802 metal binding site [ion binding]; metal-binding site 218491016803 interdomain interaction site; other site 218491016804 HMMPfam hit to PF01751, DE Toprim domain, score 2e-05 218491016805 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 2.3e-27 218491016806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491016807 non-specific DNA binding site [nucleotide binding]; other site 218491016808 salt bridge; other site 218491016809 sequence-specific DNA binding site [nucleotide binding]; other site 218491016810 HMMPfam hit to PF01381, DE Helix-turn-helix, score 2.4e-14 218491016811 Predicted helix-turn-helix motif with score 2637.000, SD 8.17 at aa 39-60, sequence ITQAELAEKLGVSQQTVQAWEA 218491016812 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491016813 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 218491016814 Signal peptide predicted for ECA3397 by SignalP 2.0 HMM (Signal peptide probabilty 0.936) with cleavage site probability 0.417 between residues 32 and 33; signal peptide 218491016815 1 probable transmembrane helix predicted for ECA3398 by TMHMM2.0 at aa 10-29 218491016816 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 218491016817 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491016818 active site 218491016819 DNA binding site [nucleotide binding] 218491016820 Int/Topo IB signature motif; other site 218491016821 HMMPfam hit to PF00589, DE Phage integrase family, score 2.4e-33 218491016822 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 0.00031 218491016823 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 218491016824 CHC2 zinc finger; Region: zf-CHC2; cl17510 218491016825 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491016826 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 218491016827 active site 218491016828 metal binding site [ion binding]; metal-binding site 218491016829 interdomain interaction site; other site 218491016830 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016831 HMMPfam hit to PF01751, DE Toprim domain, score 0.0014 218491016832 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 3.5e-24 218491016833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491016834 non-specific DNA binding site [nucleotide binding]; other site 218491016835 salt bridge; other site 218491016836 sequence-specific DNA binding site [nucleotide binding]; other site 218491016837 Predicted helix-turn-helix motif with score 2362.000, SD 7.23 at aa 31-63, sequence KRITALRKEAGMTQTQVAQALNVSQQAVQAWEA 218491016838 Predicted helix-turn-helix motif with score 1445.000, SD 4.11 at aa 31-52, sequence KRITALRKEAGMTQTQVAQALN 218491016839 HMMPfam hit to PF01381, DE Helix-turn-helix, score 9.3e-14 218491016840 Predicted helix-turn-helix motif with score 2362.000, SD 7.23 at aa 42-63, sequence MTQTQVAQALNVSQQAVQAWEA 218491016841 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491016842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 218491016843 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 218491016844 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491016845 active site 218491016846 DNA binding site [nucleotide binding] 218491016847 Int/Topo IB signature motif; other site 218491016848 HMMPfam hit to PF00589, DE Phage integrase family, score 7e-32 218491016849 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 7.3e-09 218491016850 CHC2 zinc finger; Region: zf-CHC2; cl17510 218491016851 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491016852 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 218491016853 active site 218491016854 metal binding site [ion binding]; metal-binding site 218491016855 interdomain interaction site; other site 218491016856 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016857 HMMPfam hit to PF01751, DE Toprim domain, score 0.00025 218491016858 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 2.5e-23 218491016859 HMMPfam hit to PF01381, DE Helix-turn-helix, score 5.9e-09 218491016860 Predicted helix-turn-helix motif with score 1948.000, SD 5.82 at aa 36-57, sequence LTQQQLAEQLGIAQQTMAHYEG 218491016861 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491016862 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491016863 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 218491016864 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 218491016865 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491016866 active site 218491016867 DNA binding site [nucleotide binding] 218491016868 Int/Topo IB signature motif; other site 218491016869 HMMPfam hit to PF00589, DE Phage integrase family, score 7e-32 218491016870 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 7.3e-09 218491016871 CHC2 zinc finger; Region: zf-CHC2; cl17510 218491016872 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491016873 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 218491016874 active site 218491016875 metal binding site [ion binding]; metal-binding site 218491016876 interdomain interaction site; other site 218491016877 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016878 HMMPfam hit to PF01751, DE Toprim domain, score 0.00025 218491016879 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 2.5e-23 218491016880 HMMPfam hit to PF01381, DE Helix-turn-helix, score 5.9e-09 218491016881 Predicted helix-turn-helix motif with score 1948.000, SD 5.82 at aa 36-57, sequence LTQQQLAEQLGIAQQTMAHYEG 218491016882 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491016883 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 218491016884 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 218491016885 RHS Repeat; Region: RHS_repeat; pfam05593 218491016886 RHS Repeat; Region: RHS_repeat; pfam05593 218491016887 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 218491016888 RHS Repeat; Region: RHS_repeat; pfam05593 218491016889 RHS Repeat; Region: RHS_repeat; pfam05593 218491016890 RHS Repeat; Region: RHS_repeat; pfam05593 218491016891 RHS protein; Region: RHS; pfam03527 218491016892 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 218491016893 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016894 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 218491016895 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 218491016896 Signal peptide predicted for ECA3424 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.375 between residues 21 and 22; signal peptide 218491016897 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 218491016898 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 218491016899 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 218491016900 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 218491016901 HMMPfam hit to PF00023, DE Ankyrin repeat, score 1.2 218491016902 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016903 Signal peptide predicted for ECA3425 by SignalP 2.0 HMM (Signal peptide probabilty 0.823) with cleavage site probability 0.342 between residues 25 and 26; signal peptide 218491016904 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 218491016905 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 218491016906 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016907 Uncharacterized conserved protein [Function unknown]; Region: COG4104 218491016908 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218491016909 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218491016910 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218491016911 PS00217 Sugar transport proteins signature 2. 218491016912 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491016913 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 218491016914 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 218491016915 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016916 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016917 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 218491016918 ImpA domain protein; Region: DUF3702; pfam12486 218491016919 1 probable transmembrane helix predicted for ECA3431 by TMHMM2.0 at aa 254-276 218491016920 Signal peptide predicted for ECA3432 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.618 between residues 35 and 36; signal peptide 218491016921 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 218491016922 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 218491016923 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 218491016924 3 probable transmembrane helices predicted for ECA3432 by TMHMM2.0 at aa 20-39, 54-76 and 450-472 218491016925 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016926 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 218491016927 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 218491016928 Signal peptide predicted for ECA3434 by SignalP 2.0 HMM (Signal peptide probabilty 0.796) with cleavage site probability 0.306 between residues 19 and 20; signal peptide 218491016929 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 218491016930 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 218491016931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491016932 Walker A motif; other site 218491016933 ATP binding site [chemical binding]; other site 218491016934 Walker B motif; other site 218491016935 arginine finger; other site 218491016936 PS00688 Sigma-54 interaction domain C-terminal part signature. 218491016937 HMMPfam hit to PF00158, DE Sigma-54 interaction domain, score 1.3e-110 218491016938 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 218491016939 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218491016940 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 218491016941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491016942 Walker A motif; other site 218491016943 ATP binding site [chemical binding]; other site 218491016944 Walker B motif; other site 218491016945 arginine finger; other site 218491016946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491016947 Walker A motif; other site 218491016948 ATP binding site [chemical binding]; other site 218491016949 Walker B motif; other site 218491016950 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 218491016951 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016952 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 2.3e-05 218491016953 PS00017 ATP/GTP-binding site motif A (P-loop). 218491016954 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 218491016955 1 probable transmembrane helix predicted for ECA3437 by TMHMM2.0 at aa 218-240 218491016956 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 218491016957 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 218491016958 Signal peptide predicted for ECA3439 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.476 between residues 28 and 29; signal peptide 218491016959 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 218491016960 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016961 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 218491016962 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 218491016963 phosphopeptide binding site; other site 218491016964 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 218491016965 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 218491016966 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 218491016967 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 218491016968 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 218491016969 Protein of unknown function (DUF877); Region: DUF877; pfam05943 218491016970 Protein of unknown function (DUF770); Region: DUF770; pfam05591 218491016971 Signal peptide predicted for ECA3446 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.434 between residues 22 and 23; signal peptide 218491016972 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 218491016973 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 1.2e-42 218491016974 HMMPfam hit to PF02321, DE Outer membrane efflux protein, score 1e-37 218491016975 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016976 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 218491016977 Signal peptide predicted for ECA3447 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.879 between residues 34 and 35; signal peptide 218491016978 Protein export membrane protein; Region: SecD_SecF; cl14618 218491016979 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 0 218491016980 11 probable transmembrane helices predicted for ECA3447 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 438-460, 475-497, 540-562, 865-887, 894-916, 921-943, 964-986 and 1001-1023 218491016981 Signal peptide predicted for ECA3448 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.262 between residues 25 and 26; signal peptide 218491016982 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 218491016983 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491016984 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 1.4e-59 218491016985 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491016986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491016987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218491016988 Predicted helix-turn-helix motif with score 1675.000, SD 4.89 at aa 50-71, sequence ANLQQIAKKAGISKATLYRIAP 218491016989 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 218491016990 Fic/DOC family; Region: Fic; cl00960 218491016991 HMMPfam hit to PF02661, DE Fic protein family, score 2.8e-25 218491016992 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 218491016993 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00622 Bacterial regulatory proteins, luxR family signature. 218491016994 4 probable transmembrane helices predicted for ECA3457 by TMHMM2.0 at aa 21-43, 53-75, 109-131 and 151-173 218491016995 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 218491016996 active site 218491016997 AAA ATPase domain; Region: AAA_15; pfam13175 218491016998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491016999 ABC transporter signature motif; other site 218491017000 Walker B; other site 218491017001 D-loop; other site 218491017002 H-loop/switch region; other site 218491017003 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017004 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 218491017005 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 218491017006 active site 218491017007 Int/Topo IB signature motif; other site 218491017008 HMMPfam hit to PF00589, DE Phage integrase family, score 1e-29 218491017009 Signal peptide predicted for ECA3461 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.989 between residues 22 and 23; signal peptide 218491017010 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 218491017011 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 218491017012 putative catalytic cysteine [active] 218491017013 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 9.3e-06 218491017014 PS01223 Gamma-glutamyl phosphate reductase signature. 218491017015 gamma-glutamyl kinase; Provisional; Region: PRK05429 218491017016 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 218491017017 nucleotide binding site [chemical binding]; other site 218491017018 homotetrameric interface [polypeptide binding]; other site 218491017019 putative phosphate binding site [ion binding]; other site 218491017020 putative allosteric binding site; other site 218491017021 PUA domain; Region: PUA; pfam01472 218491017022 HMMPfam hit to PF01472, DE PUA domain, score 1.7e-19 218491017023 HMMPfam hit to PF00696, DE Amino acid kinase family, score 5.2e-58 218491017024 PS00902 Glutamate 5-kinase signature. 218491017025 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 218491017026 PS00213 Lipocalin signature. 218491017027 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 218491017028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491017029 active site 218491017030 HMMPfam hit to PF00156, DE Phosphoribosyl transferase domain, score 2.1e-11 218491017031 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491017032 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 218491017033 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 218491017034 metal binding site [ion binding]; metal-binding site 218491017035 dimer interface [polypeptide binding]; other site 218491017036 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 8.1e-19 218491017037 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 218491017038 active site 218491017039 DNA polymerase IV; Validated; Region: PRK02406 218491017040 DNA binding site [nucleotide binding] 218491017041 HMMPfam hit to PF00817, DE impB/mucB/samB family, score 2.1e-114 218491017042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491017043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491017044 salt bridge; other site 218491017045 non-specific DNA binding site [nucleotide binding]; other site 218491017046 sequence-specific DNA binding site [nucleotide binding]; other site 218491017047 Predicted helix-turn-helix motif with score 1150.000, SD 3.10 at aa 47-68, sequence LRREELAQIARISTTWYTWIEQ 218491017048 Methyltransferase domain; Region: Methyltransf_31; pfam13847 218491017049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491017050 S-adenosylmethionine binding site [chemical binding]; other site 218491017051 HMMPfam hit to PF01209, DE ubiE/COQ5 methyltransferase family, score 1.2e-07 218491017052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 218491017053 Signal peptide predicted for ECA3471 by SignalP 2.0 HMM (Signal peptide probabilty 0.819) with cleavage site probability 0.216 between residues 23 and 24; signal peptide 218491017054 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 218491017055 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 218491017056 putative active site [active] 218491017057 putative dimer interface [polypeptide binding]; other site 218491017058 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 218491017059 dimer interface [polypeptide binding]; other site 218491017060 active site 218491017061 HMMPfam hit to PF01380, DE SIS domain, score 7.7e-42 218491017062 Signal peptide predicted for ECA3474 by SignalP 2.0 HMM (Signal peptide probabilty 0.922) with cleavage site probability 0.722 between residues 38 and 39; signal peptide 218491017063 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 218491017064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 218491017065 active site 218491017066 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 218491017067 2 probable transmembrane helices predicted for ECA3474 by TMHMM2.0 at aa 10-32 and 39-61 218491017068 HMMPfam hit to PF02771, DE Acyl-CoA dehydrogenase, N-terminal domain, score 0.00058 218491017069 HMMPfam hit to PF00441, DE Acyl-CoA dehydrogenase, C-terminal domain, score 9.4e-25 218491017070 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 218491017071 active site 218491017072 PS00190 Cytochrome c family heme-binding site signature. 218491017073 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 218491017074 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 218491017075 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 218491017076 HMMPfam hit to PF01008, DE Initiation factor 2 subunit family, score 1.3e-83 218491017077 PAAR motif; Region: PAAR_motif; pfam05488 218491017078 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 218491017079 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 218491017080 1 probable transmembrane helix predicted for ECA3480 by TMHMM2.0 at aa 25-44 218491017081 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 218491017082 1 probable transmembrane helix predicted for ECA3481 by TMHMM2.0 at aa 25-44 218491017083 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 218491017084 Pseudogene. This CDS contains an in-frame TAG stop codon. Similar to Escherichia coli vgrg protein SWALL:O52672 (EMBL:AF044503) (713 aa) fasta scores: E(): 4.8e-75, 38.19% id in 576 aa, and to Vibrio cholerae vgrg protein vca0018 SWALL:Q9KNE7 (EMBL:AE004345) (694 aa) fasta scores: E(): 4.9e-118, 51.71% id in 640 aa;VgrG protein (pseudogene) 218491017085 PS00217 Sugar transport proteins signature 2. 218491017086 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 218491017087 Cupin domain; Region: Cupin_2; cl17218 218491017088 HMMPfam hit to PF03079, DE ARD/ARD' family, score 1.3e-36 218491017089 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 218491017090 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 218491017091 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 1e-09 218491017092 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 218491017093 intersubunit interface [polypeptide binding]; other site 218491017094 active site 218491017095 Zn2+ binding site [ion binding]; other site 218491017096 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00596, DE Class II Aldolase and Adducin N-terminal domain, score 1.1e-34 218491017097 methionine aminotransferase; Validated; Region: PRK09082 218491017098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491017099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491017100 homodimer interface [polypeptide binding]; other site 218491017101 catalytic residue [active] 218491017102 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 7.4e-29 218491017103 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017104 C-N hydrolase family amidase; Provisional; Region: PRK10438 218491017105 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 218491017106 putative active site [active] 218491017107 catalytic triad [active] 218491017108 dimer interface [polypeptide binding]; other site 218491017109 multimer interface [polypeptide binding]; other site 218491017110 HMMPfam hit to PF00795, DE Carbon-nitrogen hydrolase, score 9.1e-23 218491017111 allantoate amidohydrolase; Reviewed; Region: PRK09290 218491017112 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 218491017113 active site 218491017114 metal binding site [ion binding]; metal-binding site 218491017115 dimer interface [polypeptide binding]; other site 218491017116 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 5.5e-23 218491017117 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218491017118 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 218491017119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491017120 catalytic residue [active] 218491017121 HMMPfam hit to PF00266, DE Aminotransferase class-V, score 3.3e-06 218491017122 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491017123 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491017124 Walker A/P-loop; other site 218491017125 ATP binding site [chemical binding]; other site 218491017126 Q-loop/lid; other site 218491017127 ABC transporter signature motif; other site 218491017128 Walker B; other site 218491017129 D-loop; other site 218491017130 H-loop/switch region; other site 218491017131 HMMPfam hit to PF00005, DE ABC transporter, score 2.9e-67 218491017132 PS00211 ABC transporters family signature. 218491017133 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017134 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 218491017135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491017136 ABC-ATPase subunit interface; other site 218491017137 putative PBP binding loops; other site 218491017138 5 probable transmembrane helices predicted for ECA3493 by TMHMM2.0 at aa 15-37, 58-80, 85-107, 141-163 and 178-200 218491017139 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4.7e-07 218491017140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491017141 dimer interface [polypeptide binding]; other site 218491017142 conserved gate region; other site 218491017143 putative PBP binding loops; other site 218491017144 ABC-ATPase subunit interface; other site 218491017145 4 probable transmembrane helices predicted for ECA3494 by TMHMM2.0 at aa 20-42, 63-85, 144-166 and 187-209 218491017146 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.7e-09 218491017147 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491017148 Signal peptide predicted for ECA3495 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 30 and 31; signal peptide 218491017149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491017150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491017151 substrate binding pocket [chemical binding]; other site 218491017152 membrane-bound complex binding site; other site 218491017153 hinge residues; other site 218491017154 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 5.2e-56 218491017155 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491017156 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 218491017157 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 218491017158 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218491017159 putative active site [active] 218491017160 Predicted helix-turn-helix motif with score 1733.000, SD 5.09 at aa 37-58, sequence YNSAELARLSGASKATVSRLFK 218491017161 Signal peptide predicted for ECA3497 by SignalP 2.0 HMM (Signal peptide probabilty 0.934) with cleavage site probability 0.537 between residues 21 and 22; signal peptide 218491017162 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 218491017163 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 218491017164 HMMPfam hit to PF01019, DE Gamma-glutamyltranspeptidase, score 9.2e-108 218491017165 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491017166 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 218491017167 amidase; Provisional; Region: PRK09201 218491017168 Amidase; Region: Amidase; cl11426 218491017169 HMMPfam hit to PF01425, DE Amidase, score 3.4e-116 218491017170 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 218491017171 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 218491017172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491017173 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 218491017174 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 218491017175 Walker A/P-loop; other site 218491017176 ATP binding site [chemical binding]; other site 218491017177 Q-loop/lid; other site 218491017178 ABC transporter signature motif; other site 218491017179 Walker B; other site 218491017180 D-loop; other site 218491017181 H-loop/switch region; other site 218491017182 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 218491017183 HMMPfam hit to PF00005, DE ABC transporter, score 1e-63 218491017184 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017185 PS00211 ABC transporters family signature. 218491017186 HMMPfam hit to PF00571, DE CBS domain, score 2.1 218491017187 HMMPfam hit to PF00571, DE CBS domain, score 0.00025 218491017188 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 218491017189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491017190 dimer interface [polypeptide binding]; other site 218491017191 conserved gate region; other site 218491017192 putative PBP binding loops; other site 218491017193 ABC-ATPase subunit interface; other site 218491017194 6 probable transmembrane helices predicted for ECA3503 by TMHMM2.0 at aa 134-156, 161-183, 187-209, 230-261, 307-329 and 336-358 218491017195 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.9e-16 218491017196 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491017197 Signal peptide predicted for ECA3504 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 22 and 23; signal peptide 218491017198 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 218491017199 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 218491017200 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 218491017201 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218491017202 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 6.8e-23 218491017203 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 218491017204 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 218491017205 CGNR zinc finger; Region: zf-CGNR; pfam11706 218491017206 Signal peptide predicted for ECA3507 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.926 between residues 34 and 35; signal peptide 218491017207 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 218491017208 Signal peptide predicted for ECA3508 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.506 between residues 38 and 39; signal peptide 218491017209 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491017210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017211 11 probable transmembrane helices predicted for ECA3508 by TMHMM2.0 at aa 16-38, 56-78, 85-104, 108-130, 143-162, 172-194, 225-247, 257-279, 292-314, 345-364 and 371-393 218491017212 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0011 218491017213 PS00012 Phosphopantetheine attachment site. 218491017214 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 218491017215 5 probable transmembrane helices predicted for ECA3509 by TMHMM2.0 at aa 19-41, 56-78, 140-162, 172-191 and 204-226 218491017216 HMMPfam hit to PF03591, DE AzlC protein, score 1.7e-64 218491017217 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017218 putative L-valine exporter; Provisional; Region: PRK10408 218491017219 3 probable transmembrane helices predicted for ECA3510 by TMHMM2.0 at aa 5-22, 42-61 and 71-93 218491017220 transcriptional repressor MprA; Provisional; Region: PRK10870 218491017221 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 218491017222 HMMPfam hit to PF01047, DE MarR family, score 3e-31 218491017223 PS01117 Bacterial regulatory proteins, marR family signature. 218491017224 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 218491017225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 218491017226 HlyD family secretion protein; Region: HlyD_3; pfam13437 218491017227 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017228 HMMPfam hit to PF00529, DE HlyD family secretion protein, score 2.7e-81 218491017229 Signal peptide predicted for ECA3513 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.513 between residues 34 and 35; signal peptide 218491017230 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 218491017231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017232 putative substrate translocation pore; other site 218491017233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017234 13 probable transmembrane helices predicted for ECA3513 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-127, 139-161, 166-188, 200-218, 233-250, 271-290, 300-322, 335-352, 367-389 and 479-497 218491017235 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0034 218491017236 Signal peptide predicted for ECA3514 by SignalP 2.0 HMM (Signal peptide probabilty 0.706) with cleavage site probability 0.522 between residues 22 and 23; signal peptide 218491017237 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 218491017238 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 218491017239 Nucleoside recognition; Region: Gate; pfam07670 218491017240 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 218491017241 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01773, DE Na+ dependent nucleoside transporter, score 9.6e-175 218491017242 9 probable transmembrane helices predicted for ECA3514 by TMHMM2.0 at aa 4-21, 42-64, 86-108, 194-216, 244-266, 273-295, 300-322, 334-356 and 371-393 218491017243 Signal peptide predicted for ECA3515 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.931 between residues 48 and 49; signal peptide 218491017244 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 218491017245 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017246 putative methyltransferase; Provisional; Region: PRK10864 218491017247 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 218491017248 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218491017249 HMMPfam hit to PF00588, DE SpoU rRNA Methylase family, score 8.2e-46 218491017250 thioredoxin 2; Provisional; Region: PRK10996 218491017251 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 218491017252 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218491017253 catalytic residues [active] 218491017254 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00085, DE Thioredoxin, score 1.5e-30 218491017255 PS00194 Thioredoxin family active site. 218491017256 Uncharacterized conserved protein [Function unknown]; Region: COG3148 218491017257 HMMPfam hit to PF03942, DE DTW domain, score 8.8e-60 218491017258 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 218491017259 CoA binding domain; Region: CoA_binding_2; pfam13380 218491017260 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 218491017261 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 218491017262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 218491017263 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 218491017264 HMMPfam hit to PF02629, DE CoA binding domain, score 2.5e-08 218491017265 PS00387 Inorganic pyrophosphatase signature. 218491017266 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 8.5e-14 218491017267 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 218491017268 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 218491017269 domain interface [polypeptide binding]; other site 218491017270 putative active site [active] 218491017271 catalytic site [active] 218491017272 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 218491017273 domain interface [polypeptide binding]; other site 218491017274 putative active site [active] 218491017275 catalytic site [active] 218491017276 HMMPfam hit to PF00614, DE Phospholipase D. Active site motif, score 5.4e-05 218491017277 HMMPfam hit to PF00614, DE Phospholipase D. Active site motif, score 0.00099 218491017278 lipoprotein; Provisional; Region: PRK10759 218491017279 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 218491017280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017281 putative substrate translocation pore; other site 218491017282 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 1.7e-83 218491017283 12 probable transmembrane helices predicted for ECA3522 by TMHMM2.0 at aa 21-43, 56-78, 90-107, 112-134, 154-176, 191-208, 238-260, 275-297, 304-326, 331-353, 366-388 and 398-417 218491017284 PS00217 Sugar transport proteins signature 2. 218491017285 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 218491017286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491017287 active site 218491017288 motif I; other site 218491017289 motif II; other site 218491017290 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 218491017291 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 218491017292 Walker A/P-loop; other site 218491017293 ATP binding site [chemical binding]; other site 218491017294 Q-loop/lid; other site 218491017295 ABC transporter signature motif; other site 218491017296 Walker B; other site 218491017297 D-loop; other site 218491017298 H-loop/switch region; other site 218491017299 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 218491017300 HMMPfam hit to PF00005, DE ABC transporter, score 4.2e-75 218491017301 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017302 PS00211 ABC transporters family signature. 218491017303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491017304 dimer interface [polypeptide binding]; other site 218491017305 conserved gate region; other site 218491017306 ABC-ATPase subunit interface; other site 218491017307 5 probable transmembrane helices predicted for ECA3525 by TMHMM2.0 at aa 17-39, 60-82, 86-105, 144-166 and 181-203 218491017308 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.5e-15 218491017309 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491017310 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 218491017311 Signal peptide predicted for ECA3526 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.374 between residues 24 and 25; signal peptide 218491017312 lipoprotein, YaeC family; Region: TIGR00363 218491017313 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017314 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03180, DE NLPA lipoprotein, score 3.5e-141 218491017315 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 218491017316 Signal peptide predicted for ECA3527 by SignalP 2.0 HMM (Signal peptide probabilty 0.830) with cleavage site probability 0.732 between residues 20 and 21; signal peptide 218491017317 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017318 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 218491017319 homodimer interaction site [polypeptide binding]; other site 218491017320 cofactor binding site; other site 218491017321 HMMPfam hit to PF01980, DE Uncharacterised protein family UPF0066, score 4.7e-51 218491017322 PS01318 Uncharacterized protein family UPF0066 signature. 218491017323 prolyl-tRNA synthetase; Provisional; Region: PRK09194 218491017324 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 218491017325 dimer interface [polypeptide binding]; other site 218491017326 motif 1; other site 218491017327 active site 218491017328 motif 2; other site 218491017329 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 218491017330 putative deacylase active site [active] 218491017331 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218491017332 active site 218491017333 motif 3; other site 218491017334 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 218491017335 anticodon binding site; other site 218491017336 HMMPfam hit to PF00587, DE tRNA synthetase class II core domain (G, H, P, S and T), score 7.2e-57 218491017337 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491017338 HMMPfam hit to PF03129, DE Anticodon binding domain, score 8.6e-29 218491017339 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 218491017340 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218491017341 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491017342 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218491017343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491017344 DNA binding residues [nucleotide binding] 218491017345 HMMPfam hit to PF00140, DE Sigma-70 factor, region 1.2, score 2e-110 218491017346 PS00716 Sigma-70 factors family signature 2. 218491017347 Predicted helix-turn-helix motif with score 1306.000, SD 3.64 at aa 286-307, sequence ATLEDVGREIGLTRERVRQIQV 218491017348 PS00715 Sigma-70 factors family signature 1. 218491017349 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 218491017350 Signal peptide predicted for ECA3531 by SignalP 2.0 HMM (Signal peptide probabilty 0.962) with cleavage site probability 0.468 between residues 29 and 30; signal peptide 218491017351 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218491017352 Peptidase family M23; Region: Peptidase_M23; pfam01551 218491017353 HMMPfam hit to PF01551, DE Peptidase family M23/M37, score 1.9e-39 218491017354 HMMPfam hit to PF01476, DE LysM domain, score 8.1e-11 218491017355 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017356 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 218491017357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491017358 S-adenosylmethionine binding site [chemical binding]; other site 218491017359 HMMPfam hit to PF01135, DE Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT), score 7.9e-113 218491017360 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491017361 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 218491017362 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 218491017363 Permutation of conserved domain; other site 218491017364 active site 218491017365 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 218491017366 HMMPfam hit to PF01142, DE Uncharacterized protein family UPF0024, score 6.1e-102 218491017367 PS01268 Uncharacterized protein family UPF0024 signature. 218491017368 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 218491017369 homotrimer interaction site [polypeptide binding]; other site 218491017370 zinc binding site [ion binding]; other site 218491017371 CDP-binding sites; other site 218491017372 HMMPfam hit to PF02542, DE YgbB family, score 2.1e-98 218491017373 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 218491017374 substrate binding site; other site 218491017375 dimer interface; other site 218491017376 HMMPfam hit to PF01128, DE Uncharacterized protein family UPF0007, score 7.5e-105 218491017377 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 218491017378 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 218491017379 Signal peptide predicted for ECA3537 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 27 and 28; signal peptide 218491017380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491017381 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491017382 substrate binding pocket [chemical binding]; other site 218491017383 membrane-bound complex binding site; other site 218491017384 hinge residues; other site 218491017385 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 9.4e-62 218491017386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491017387 dimer interface [polypeptide binding]; other site 218491017388 conserved gate region; other site 218491017389 putative PBP binding loops; other site 218491017390 ABC-ATPase subunit interface; other site 218491017391 4 probable transmembrane helices predicted for ECA3538 by TMHMM2.0 at aa 26-48, 68-90, 119-141 and 219-241 218491017392 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 5e-19 218491017393 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491017394 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491017395 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491017396 Walker A/P-loop; other site 218491017397 ATP binding site [chemical binding]; other site 218491017398 Q-loop/lid; other site 218491017399 ABC transporter signature motif; other site 218491017400 Walker B; other site 218491017401 D-loop; other site 218491017402 H-loop/switch region; other site 218491017403 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-65 218491017404 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017405 PS00211 ABC transporters family signature. 218491017406 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 218491017407 3 probable transmembrane helices predicted for ECA3540 by TMHMM2.0 at aa 26-48, 63-85 and 87-109 218491017408 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 218491017409 ligand-binding site [chemical binding]; other site 218491017410 HMMPfam hit to PF01583, DE Adenylylsulphate kinase, score 2.4e-110 218491017411 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017412 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 218491017413 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 218491017414 CysD dimerization site [polypeptide binding]; other site 218491017415 G1 box; other site 218491017416 putative GEF interaction site [polypeptide binding]; other site 218491017417 GTP/Mg2+ binding site [chemical binding]; other site 218491017418 Switch I region; other site 218491017419 G2 box; other site 218491017420 G3 box; other site 218491017421 Switch II region; other site 218491017422 G4 box; other site 218491017423 G5 box; other site 218491017424 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 218491017425 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 218491017426 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 8.8e-10 218491017427 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 4e-69 218491017428 PS00301 GTP-binding elongation factors signature. 218491017429 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017430 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 218491017431 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218491017432 Active Sites [active] 218491017433 HMMPfam hit to PF01507, DE Phosphoadenosine phosphosulfate reductase family, score 7.7e-95 218491017434 siroheme synthase; Provisional; Region: cysG; PRK10637 218491017435 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 218491017436 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 218491017437 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 218491017438 active site 218491017439 SAM binding site [chemical binding]; other site 218491017440 homodimer interface [polypeptide binding]; other site 218491017441 HMMPfam hit to PF00590, DE Tetrapyrrole (Corrin/Porphyrin) Methylases, score 6.9e-87 218491017442 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 218491017443 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 218491017444 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 218491017445 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 218491017446 Active Sites [active] 218491017447 HMMPfam hit to PF01507, DE Phosphoadenosine phosphosulfate reductase family, score 3.9e-81 218491017448 sulfite reductase subunit beta; Provisional; Region: PRK13504 218491017449 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218491017450 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218491017451 HMMPfam hit to PF01077, DE Nitrite and sulphite reductase 4Fe-4S domain, score 1.6e-28 218491017452 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 218491017453 HMMPfam hit to PF03460, DE Nitrite/Sulfite reductase ferredoxin-like half domain, score 3.9e-17 218491017454 HMMPfam hit to PF03460, DE Nitrite/Sulfite reductase ferredoxin-like half domain, score 1.3e-17 218491017455 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 218491017456 Flavodoxin; Region: Flavodoxin_1; pfam00258 218491017457 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 218491017458 FAD binding pocket [chemical binding]; other site 218491017459 FAD binding motif [chemical binding]; other site 218491017460 catalytic residues [active] 218491017461 NAD binding pocket [chemical binding]; other site 218491017462 phosphate binding motif [ion binding]; other site 218491017463 beta-alpha-beta structure motif; other site 218491017464 HMMPfam hit to PF00175, DE Oxidoreductase NAD-binding domain, score 2e-40 218491017465 HMMPfam hit to PF00667, DE FAD binding domain, score 7.8e-59 218491017466 HMMPfam hit to PF00258, DE Flavodoxin, score 3.7e-38 218491017467 PilZ domain; Region: PilZ; pfam07238 218491017468 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218491017469 Zn2+ binding site [ion binding]; other site 218491017470 Mg2+ binding site [ion binding]; other site 218491017471 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 218491017472 HMMPfam hit to PF00563, DE EAL domain, score 1.5e-24 218491017473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218491017474 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218491017475 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 6.3e-30 218491017476 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 218491017477 HMMPfam hit to PF00295, DE Glycosyl hydrolases family 28, score 0.00011 218491017478 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 218491017479 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 218491017480 active site 218491017481 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01242, DE 6-pyruvoyl tetrahydropterin synthase, score 1.9e-71 218491017482 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 218491017483 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 218491017484 HMMPfam hit to PF02143, , score 3.4e-08 218491017485 Signal peptide predicted for ECA3555 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.851 between residues 23 and 24; signal peptide 218491017486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218491017487 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 9e-09 218491017488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491017489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491017490 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 218491017491 putative substrate binding pocket [chemical binding]; other site 218491017492 putative dimerization interface [polypeptide binding]; other site 218491017493 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 8.1e-18 218491017494 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 8.4e-19 218491017495 Predicted helix-turn-helix motif with score 1201.000, SD 3.28 at aa 34-55, sequence KSVSAAADKLHLGQPAVSGALA 218491017496 Signal peptide predicted for ECA3557 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.827 between residues 25 and 26; signal peptide 218491017497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 218491017498 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 5.4e-11 218491017499 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 218491017500 classical (c) SDRs; Region: SDR_c; cd05233 218491017501 NAD(P) binding site [chemical binding]; other site 218491017502 active site 218491017503 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00106, DE short chain dehydrogenase, score 3.6e-63 218491017504 PS00061 Short-chain dehydrogenases/reductases family signature. 218491017505 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 218491017506 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218491017507 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 218491017508 12 probable transmembrane helices predicted for ECA3560 by TMHMM2.0 at aa 13-35, 45-67, 86-103, 108-130, 151-173, 178-200, 254-276, 286-308, 315-334, 339-361, 397-419 and 424-446 218491017509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491017510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491017511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491017512 dimerization interface [polypeptide binding]; other site 218491017513 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.2e-14 218491017514 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.4e-21 218491017515 PS00044 Bacterial regulatory proteins, lysR family signature. 218491017516 Predicted helix-turn-helix motif with score 1918.000, SD 5.72 at aa 16-37, sequence RSISGAARALNLTQPAVSQHIA 218491017517 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 218491017518 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 218491017519 NAD(P) binding site [chemical binding]; other site 218491017520 catalytic residues [active] 218491017521 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 8.6e-115 218491017522 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491017523 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 218491017524 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 218491017525 potential catalytic triad [active] 218491017526 conserved cys residue [active] 218491017527 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01965, DE DJ-1/PfpI family, score 7.6e-27 218491017528 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 218491017529 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 218491017530 putative ligand binding residues [chemical binding]; other site 218491017531 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 1.7e-05 218491017532 Signal peptide predicted for ECA3565 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.639 between residues 28 and 29; signal peptide 218491017533 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491017534 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491017535 N-terminal plug; other site 218491017536 ligand-binding site [chemical binding]; other site 218491017537 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 6.6e-13 218491017538 enolase; Provisional; Region: eno; PRK00077 218491017539 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 218491017540 dimer interface [polypeptide binding]; other site 218491017541 metal binding site [ion binding]; metal-binding site 218491017542 substrate binding pocket [chemical binding]; other site 218491017543 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00113, DE Enolase, C-terminal TIM barrel domain, score 5.4e-183 218491017544 PS00164 Enolase signature. 218491017545 HMMPfam hit to PF03952, DE Enolase, N-terminal domain, score 3.3e-68 218491017546 Signal peptide predicted for ECA3567 by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.901 between residues 26 and 27; signal peptide 218491017547 CTP synthetase; Validated; Region: pyrG; PRK05380 218491017548 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 218491017549 Catalytic site [active] 218491017550 active site 218491017551 UTP binding site [chemical binding]; other site 218491017552 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 218491017553 active site 218491017554 putative oxyanion hole; other site 218491017555 catalytic triad [active] 218491017556 HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 4.8e-74 218491017557 PS00442 Glutamine amidotransferases class-I active site. 218491017558 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 218491017559 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 218491017560 homodimer interface [polypeptide binding]; other site 218491017561 metal binding site [ion binding]; metal-binding site 218491017562 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 218491017563 homodimer interface [polypeptide binding]; other site 218491017564 active site 218491017565 putative chemical substrate binding site [chemical binding]; other site 218491017566 metal binding site [ion binding]; metal-binding site 218491017567 HMMPfam hit to PF03819, DE MazG family protein, score 6.7e-140 218491017568 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491017569 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 218491017570 HD domain; Region: HD_4; pfam13328 218491017571 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218491017572 synthetase active site [active] 218491017573 NTP binding site [chemical binding]; other site 218491017574 metal binding site [ion binding]; metal-binding site 218491017575 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 218491017576 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 218491017577 HMMPfam hit to PF01842, DE ACT domain, score 4e-12 218491017578 HMMPfam hit to PF02824, DE TGS domain, score 4.9e-30 218491017579 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 218491017580 TRAM domain; Region: TRAM; pfam01938 218491017581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 218491017582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491017583 S-adenosylmethionine binding site [chemical binding]; other site 218491017584 PS01231 RNA methyltransferase trmA family signature 2. 218491017585 PS01230 RNA methyltransferase trmA family signature 1. 218491017586 HMMPfam hit to PF01938, DE TRAM domain, score 9.3e-10 218491017587 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 218491017588 Signal peptide predicted for ECA3571 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.365 between residues 39 and 40; signal peptide 218491017589 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 218491017590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491017591 dimerization interface [polypeptide binding]; other site 218491017592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491017593 dimer interface [polypeptide binding]; other site 218491017594 phosphorylation site [posttranslational modification] 218491017595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491017596 ATP binding site [chemical binding]; other site 218491017597 Mg2+ binding site [ion binding]; other site 218491017598 G-X-G motif; other site 218491017599 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 218491017600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491017601 active site 218491017602 phosphorylation site [posttranslational modification] 218491017603 intermolecular recognition site; other site 218491017604 dimerization interface [polypeptide binding]; other site 218491017605 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 218491017606 putative binding surface; other site 218491017607 active site 218491017608 2 probable transmembrane helices predicted for ECA3571 by TMHMM2.0 at aa 10-32 and 177-199 218491017609 HMMPfam hit to PF00672, DE HAMP domain, score 1.2e-09 218491017610 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 1.7e-23 218491017611 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 3.2e-39 218491017612 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.3e-29 218491017613 HMMPfam hit to PF01627, DE Hpt domain, score 1.7e-19 218491017614 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 218491017615 HMMPfam hit to PF02595, DE Glycerate kinase family, score 2.2e-237 218491017616 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 218491017617 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218491017618 HMMPfam hit to PF03446, DE NAD binding domain of 6-phosphogluconate dehydrogenase, score 0.00026 218491017619 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 218491017620 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 218491017621 HMMPfam hit to PF03328, DE HpcH/HpaI aldolase family, score 2e-136 218491017622 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 218491017623 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 218491017624 active site 218491017625 tetramer interface [polypeptide binding]; other site 218491017626 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218491017627 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 0.00061 218491017628 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017629 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 218491017630 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 218491017631 active site 218491017632 tetramer interface [polypeptide binding]; other site 218491017633 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 5.3e-05 218491017634 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 218491017635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017636 D-galactonate transporter; Region: 2A0114; TIGR00893 218491017637 putative substrate translocation pore; other site 218491017638 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00022 218491017639 11 probable transmembrane helices predicted for ECA3577 by TMHMM2.0 at aa 20-42, 57-79, 92-114, 152-174, 179-201, 258-280, 292-314, 329-346, 351-373, 388-410 and 417-436 218491017640 galactarate dehydratase; Region: galactar-dH20; TIGR03248 218491017641 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 218491017642 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 218491017643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491017644 PAS domain; Region: PAS_9; pfam13426 218491017645 putative active site [active] 218491017646 heme pocket [chemical binding]; other site 218491017647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218491017648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491017649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491017650 dimer interface [polypeptide binding]; other site 218491017651 putative CheW interface [polypeptide binding]; other site 218491017652 1 probable transmembrane helix predicted for ECA3579 by TMHMM2.0 at aa 171-193 218491017653 HMMPfam hit to PF00672, DE HAMP domain, score 4.4e-05 218491017654 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 3.2e-70 218491017655 Signal peptide predicted for ECA3581 by SignalP 2.0 HMM (Signal peptide probabilty 0.932) with cleavage site probability 0.355 between residues 23 and 24; signal peptide 218491017656 Predicted helix-turn-helix motif with score 1248.000, SD 3.44 at aa 94-115, sequence SSTTQNAKQEGVNRPTADNKIN 218491017657 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 218491017658 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 218491017659 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 218491017660 nucleotide binding pocket [chemical binding]; other site 218491017661 K-X-D-G motif; other site 218491017662 catalytic site [active] 218491017663 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218491017664 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 218491017665 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 218491017666 Dimer interface [polypeptide binding]; other site 218491017667 BRCT sequence motif; other site 218491017668 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00533, DE BRCA1 C Terminus (BRCT) domain, score 1.7e-14 218491017669 HMMPfam hit to PF03119, DE NAD-dependent DNA ligase C4 zinc finger domain, score 3.2e-10 218491017670 HMMPfam hit to PF03120, DE NAD-dependent DNA ligase OB-fold domain, score 5.9e-46 218491017671 PS01056 NAD-dependent DNA ligase signature 2. 218491017672 HMMPfam hit to PF01653, DE NAD-dependent DNA ligase adenylation domain, score 3.9e-197 218491017673 PS01055 NAD-dependent DNA ligase signature 1. 218491017674 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 218491017675 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 218491017676 putative ribose interaction site [chemical binding]; other site 218491017677 putative ADP binding site [chemical binding]; other site 218491017678 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 218491017679 active site 218491017680 nucleotide binding site [chemical binding]; other site 218491017681 HIGH motif; other site 218491017682 KMSKS motif; other site 218491017683 HMMPfam hit to PF01467, DE Cytidylyltransferase, score 5.8e-37 218491017684 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 1.7e-52 218491017685 PS00583 pfkB family of carbohydrate kinases signature 1. 218491017686 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 218491017687 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 218491017688 metal binding triad; other site 218491017689 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 218491017690 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 218491017691 metal binding triad; other site 218491017692 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 218491017693 HMMPfam hit to PF03710, DE Glutamate-ammonia ligase adenylyltransferase, score 2.2e-124 218491017694 HMMPfam hit to PF03710, DE Glutamate-ammonia ligase adenylyltransferase, score 7.4e-123 218491017695 Uncharacterized conserved protein [Function unknown]; Region: COG3025 218491017696 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 218491017697 putative active site [active] 218491017698 putative metal binding residues [ion binding]; other site 218491017699 signature motif; other site 218491017700 putative triphosphate binding site [ion binding]; other site 218491017701 SH3 domain-containing protein; Provisional; Region: PRK10884 218491017702 Signal peptide predicted for ECA3587 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.988 between residues 22 and 23; signal peptide 218491017703 Bacterial SH3 domain homologues; Region: SH3b; smart00287 218491017704 1 probable transmembrane helix predicted for ECA3587 by TMHMM2.0 at aa 173-195 218491017705 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 218491017706 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218491017707 active site 218491017708 NTP binding site [chemical binding]; other site 218491017709 metal binding triad [ion binding]; metal-binding site 218491017710 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218491017711 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218491017712 Zn2+ binding site [ion binding]; other site 218491017713 Mg2+ binding site [ion binding]; other site 218491017714 HMMPfam hit to PF01743, DE Poly A polymerase family, score 7.3e-59 218491017715 HMMPfam hit to PF01966, DE HD domain, score 9.2e-15 218491017716 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 218491017717 7 probable transmembrane helices predicted for ECA3589 by TMHMM2.0 at aa 7-40, 50-69, 89-111, 121-138, 186-208, 223-245 and 252-271 218491017718 HMMPfam hit to PF02673, DE Bacitracin resistance protein BacA, score 5e-66 218491017719 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 218491017720 homooctamer interface [polypeptide binding]; other site 218491017721 active site 218491017722 HMMPfam hit to PF02152, DE Dihydroneopterin aldolase, score 5.9e-45 218491017723 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 218491017724 Signal peptide predicted for ECA3591 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.924 between residues 20 and 21; signal peptide 218491017725 5 probable transmembrane helices predicted for ECA3591 by TMHMM2.0 at aa 5-24, 53-75, 80-102, 109-131 and 136-158 218491017726 HMMPfam hit to PF02660, DE Domain of unknown function DUF, score 5.8e-99 218491017727 Signal peptide predicted for ECA3592 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.336 between residues 35 and 36; signal peptide 218491017728 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 218491017729 dimer interface [polypeptide binding]; other site 218491017730 ligand binding site [chemical binding]; other site 218491017731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491017732 dimerization interface [polypeptide binding]; other site 218491017733 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491017734 dimer interface [polypeptide binding]; other site 218491017735 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 218491017736 putative CheW interface [polypeptide binding]; other site 218491017737 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 4.7e-93 218491017738 HMMPfam hit to PF00672, DE HAMP domain, score 1.8e-10 218491017739 2 probable transmembrane helices predicted for ECA3592 by TMHMM2.0 at aa 10-32 and 193-212 218491017740 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491017741 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491017742 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 218491017743 dimer interface [polypeptide binding]; other site 218491017744 substrate binding site [chemical binding]; other site 218491017745 metal binding sites [ion binding]; metal-binding site 218491017746 HMMPfam hit to PF00719, DE Inorganic pyrophosphatase, score 1.2e-59 218491017747 PS00387 Inorganic pyrophosphatase signature. 218491017748 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 218491017749 putative active site pocket [active] 218491017750 dimerization interface [polypeptide binding]; other site 218491017751 putative catalytic residue [active] 218491017752 HMMPfam hit to PF03674, DE Uncharacterised protein family (UPF0131), score 5.7e-13 218491017753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 218491017754 Family of unknown function (DUF490); Region: DUF490; pfam04357 218491017755 1 probable transmembrane helix predicted for ECA3595 by TMHMM2.0 at aa 38-60 218491017756 Signal peptide predicted for ECA3596 by SignalP 2.0 HMM (Signal peptide probabilty 0.760) with cleavage site probability 0.734 between residues 61 and 62; signal peptide 218491017757 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 218491017758 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218491017759 Surface antigen; Region: Bac_surface_Ag; pfam01103 218491017760 PS00213 Lipocalin signature. 218491017761 methionine sulfoxide reductase A; Provisional; Region: PRK00058 218491017762 HMMPfam hit to PF01625, DE Peptide methionine sulfoxide reductase, score 5.6e-104 218491017763 Signal peptide predicted for ECA3598 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.776 between residues 26 and 27; signal peptide 218491017764 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218491017765 Domain of unknown function DUF21; Region: DUF21; pfam01595 218491017766 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218491017767 Transporter associated domain; Region: CorC_HlyC; smart01091 218491017768 HMMPfam hit to PF01595, DE Domain of unknown function DUF21, score 6.3e-67 218491017769 4 probable transmembrane helices predicted for ECA3598 by TMHMM2.0 at aa 5-27, 54-76, 100-117 and 144-162 218491017770 HMMPfam hit to PF00571, DE CBS domain, score 0.024 218491017771 HMMPfam hit to PF00571, DE CBS domain, score 0.00014 218491017772 HMMPfam hit to PF03471, DE Transporter associated domain, score 1.7e-28 218491017773 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 218491017774 Signal peptide predicted for ECA3600 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 26 and 27; signal peptide 218491017775 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 218491017776 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 218491017777 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 218491017778 active site 218491017779 HMMPfam hit to PF00459, DE Inositol monophosphatase family, score 8.4e-66 218491017780 PS00630 Inositol monophosphatase family signature 2. 218491017781 PS00629 Inositol monophosphatase family signature 1. 218491017782 Signal peptide predicted for ECA3602 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 20 and 21; signal peptide 218491017783 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 218491017784 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 218491017785 active site 218491017786 metal binding site [ion binding]; metal-binding site 218491017787 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218491017788 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 8.5e-16 218491017789 PS00785 5'-nucleotidase signature 1. 218491017790 PS00786 5'-nucleotidase signature 2. 218491017791 HMMPfam hit to PF02872, DE 5'-nucleotidase, C-terminal domain, score 3.1e-64 218491017792 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 218491017793 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 218491017794 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 218491017795 PS00201 Flavodoxin signature. 218491017796 Signal peptide predicted for ECA3604 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.454 between residues 23 and 24; signal peptide 218491017797 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 218491017798 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 218491017799 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 218491017800 dimer interface [polypeptide binding]; other site 218491017801 PYR/PP interface [polypeptide binding]; other site 218491017802 TPP binding site [chemical binding]; other site 218491017803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491017804 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 218491017805 TPP-binding site [chemical binding]; other site 218491017806 dimer interface [polypeptide binding]; other site 218491017807 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 7.8e-62 218491017808 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 1.4e-15 218491017809 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 2.7e-54 218491017810 PS00187 Thiamine pyrophosphate enzymes signature. 218491017811 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 218491017812 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 218491017813 Hemerythrin-like domain; Region: Hr-like; cd12108 218491017814 Fe binding site [ion binding]; other site 218491017815 HMMPfam hit to PF03794, DE Domain of Unknown function, score 6.3e-14 218491017816 HMMPfam hit to PF03794, DE Domain of Unknown function, score 1.6e-15 218491017817 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 218491017818 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 218491017819 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218491017820 HMMPfam hit to PF00254, DE FKBP-type peptidyl-prolyl cis-trans isomerase, score 1.6e-41 218491017821 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218491017822 HMMPfam hit to PF01346, DE Domain amino terminal to FKBP-type peptidyl-prolyl isomerase, score 7.9e-07 218491017823 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 218491017824 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 218491017825 1 probable transmembrane helix predicted for ECA3608 by TMHMM2.0 at aa 84-101 218491017826 Protein of unknown function, DUF488; Region: DUF488; cl01246 218491017827 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 218491017828 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 218491017829 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 218491017830 HMMPfam hit to PF03948, DE Ribosomal protein L9, C-terminal domain, score 5.7e-38 218491017831 HMMPfam hit to PF01281, DE Ribosomal protein L9, N-terminal domain, score 5.2e-28 218491017832 PS00651 Ribosomal protein L9 signature. 218491017833 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 218491017834 HMMPfam hit to PF01084, DE Ribosomal protein S18, score 1.5e-30 218491017835 PS00057 Ribosomal protein S18 signature. 218491017836 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218491017837 dimer interface [polypeptide binding]; other site 218491017838 ssDNA binding site [nucleotide binding]; other site 218491017839 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218491017840 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017841 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 218491017842 HMMPfam hit to PF01250, DE Ribosomal protein S6, score 5.6e-47 218491017843 PS01048 Ribosomal protein S6 signature. 218491017844 esterase; Provisional; Region: PRK10566 218491017845 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218491017846 Signal peptide predicted for ECA3615 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.948 between residues 38 and 39; signal peptide 218491017847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491017848 dimerization interface [polypeptide binding]; other site 218491017849 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491017850 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491017851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491017852 dimer interface [polypeptide binding]; other site 218491017853 putative CheW interface [polypeptide binding]; other site 218491017854 2 probable transmembrane helices predicted for ECA3615 by TMHMM2.0 at aa 15-34 and 323-342 218491017855 HMMPfam hit to PF03915, DE Actin interacting protein 3, score 7.7 218491017856 HMMPfam hit to PF00672, DE HAMP domain, score 3.4e-10 218491017857 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.1e-68 218491017858 hypothetical protein; Reviewed; Region: PRK09588 218491017859 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 218491017860 HMMPfam hit to PF01139, DE Uncharacterized protein family UPF0027, score 2.6e-11 218491017861 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 218491017862 putative peptide chain release factor H; Region: release_prfH; TIGR03072 218491017863 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00472, DE Peptidyl-tRNA hydrolase domain, score 4.9e-28 218491017864 Signal peptide predicted for ECA3618 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.993 between residues 21 and 22; signal peptide 218491017865 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 218491017866 Signal peptide predicted for ECA3619 by SignalP 2.0 HMM (Signal peptide probabilty 0.962) with cleavage site probability 0.483 between residues 23 and 24; signal peptide 218491017867 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017868 Predicted membrane protein [Function unknown]; Region: COG3766 218491017869 Signal peptide predicted for ECA3620 by SignalP 2.0 HMM (Signal peptide probabilty 0.921) with cleavage site probability 0.422 between residues 23 and 24; signal peptide 218491017870 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 218491017871 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 218491017872 4 probable transmembrane helices predicted for ECA3620 by TMHMM2.0 at aa 6-28, 48-70, 75-97 and 109-131 218491017873 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 218491017874 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 218491017875 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218491017876 HMMPfam hit to PF00588, DE SpoU rRNA Methylase family, score 8.5e-62 218491017877 exoribonuclease R; Provisional; Region: PRK11642 218491017878 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 218491017879 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 218491017880 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218491017881 RNB domain; Region: RNB; pfam00773 218491017882 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 218491017883 RNA binding site [nucleotide binding]; other site 218491017884 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 2.5e-16 218491017885 HMMPfam hit to PF00773, DE RNB-like protein, score 2e-136 218491017886 transcriptional repressor NsrR; Provisional; Region: PRK11014 218491017887 Rrf2 family protein; Region: rrf2_super; TIGR00738 218491017888 HMMPfam hit to PF02082, DE Transcriptional regulator, score 1e-41 218491017889 PS01332 Uncharacterized protein family UPF0074 signature. 218491017890 Predicted helix-turn-helix motif with score 1160.000, SD 3.14 at aa 16-37, sequence TSISEVTEVYGVSRNHMVKIIN 218491017891 Signal peptide predicted for ECA3624 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.336 between residues 33 and 34; signal peptide 218491017892 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 218491017893 dimer interface [polypeptide binding]; other site 218491017894 ligand binding site [chemical binding]; other site 218491017895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491017896 dimerization interface [polypeptide binding]; other site 218491017897 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491017898 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491017899 dimer interface [polypeptide binding]; other site 218491017900 putative CheW interface [polypeptide binding]; other site 218491017901 2 probable transmembrane helices predicted for ECA3624 by TMHMM2.0 at aa 10-32 and 192-214 218491017902 HMMPfam hit to PF00672, DE HAMP domain, score 1.2e-08 218491017903 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 3.5e-81 218491017904 PAS domain S-box; Region: sensory_box; TIGR00229 218491017905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491017906 putative active site [active] 218491017907 heme pocket [chemical binding]; other site 218491017908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 218491017909 PAS domain; Region: PAS_9; pfam13426 218491017910 putative active site [active] 218491017911 heme pocket [chemical binding]; other site 218491017912 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 218491017913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491017914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491017915 metal binding site [ion binding]; metal-binding site 218491017916 active site 218491017917 I-site; other site 218491017918 HMMPfam hit to PF00785, DE PAC motif, score 0.00028 218491017919 HMMPfam hit to PF00785, DE PAC motif, score 0.00091 218491017920 HMMPfam hit to PF01590, DE GAF domain, score 2.3e-05 218491017921 PS00881 Protein splicing signature. 218491017922 HMMPfam hit to PF00990, DE GGDEF domain, score 5.1e-55 218491017923 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 218491017924 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 218491017925 Walker A motif; other site 218491017926 ATP binding site [chemical binding]; other site 218491017927 Walker B motif; other site 218491017928 HMMPfam hit to PF00437, DE Type II/IV secretion system protein, score 1.7e-19 218491017929 PS00662 Bacterial type II secretion system protein E signature. 218491017930 PS00017 ATP/GTP-binding site motif A (P-loop). 218491017931 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 218491017932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491017933 catalytic residue [active] 218491017934 HMMPfam hit to PF01168, DE Alanine racemase, N-terminal domain, score 8.1e-142 218491017935 PS01211 Uncharacterized protein family UPF0001 signature. 218491017936 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 218491017937 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 218491017938 HMMPfam hit to PF01089, DE Delta 1-pyrroline-5-carboxylate reductase, score 1.2e-100 218491017939 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 218491017940 YGGT family; Region: YGGT; pfam02325 218491017941 Predicted integral membrane protein [Function unknown]; Region: COG0762 218491017942 HMMPfam hit to PF02325, DE YGGT family, score 2.1e-21 218491017943 4 probable transmembrane helices predicted for ECA3629 by TMHMM2.0 at aa 2-24, 66-88, 95-116 and 161-183 218491017944 HMMPfam hit to PF02325, DE YGGT family, score 2.2e-26 218491017945 hypothetical protein; Validated; Region: PRK05090 218491017946 HMMPfam hit to PF02594, DE Uncharacterized ACR, YggU family COG1872, score 2.4e-34 218491017947 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 218491017948 active site 218491017949 dimerization interface [polypeptide binding]; other site 218491017950 HMMPfam hit to PF01725, DE Ham1 family, score 3.2e-102 218491017951 HemN family oxidoreductase; Provisional; Region: PRK05660 218491017952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491017953 FeS/SAM binding site; other site 218491017954 HemN C-terminal domain; Region: HemN_C; pfam06969 218491017955 HMMPfam hit to PF02473, , score 1.9e-14 218491017956 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 218491017957 HMMPfam hit to PF03693, DE Uncharacterised protein family (UPF0156), score 2.4e-09 218491017958 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491017959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491017960 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491017961 putative effector binding pocket; other site 218491017962 dimerization interface [polypeptide binding]; other site 218491017963 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.9e-30 218491017964 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 9.4e-16 218491017965 PS00044 Bacterial regulatory proteins, lysR family signature. 218491017966 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491017967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017968 putative substrate translocation pore; other site 218491017969 12 probable transmembrane helices predicted for ECA3635 by TMHMM2.0 at aa 21-43, 58-80, 85-104, 109-131, 143-165, 170-192, 213-235, 240-262, 274-296, 300-322, 334-356 and 371-388 218491017970 Signal peptide predicted for ECA3636 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 25 and 26; signal peptide 218491017971 Signal peptide predicted for ECA3637 by SignalP 2.0 HMM (Signal peptide probabilty 0.929) with cleavage site probability 0.778 between residues 17 and 18; signal peptide 218491017972 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017973 entericidin A; Provisional; Region: PRK09810 218491017974 Signal peptide predicted for ECA3638 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.597 between residues 28 and 29; signal peptide 218491017975 1 probable transmembrane helix predicted for ECA3638 by TMHMM2.0 at aa 7-29 218491017976 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491017977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491017978 Coenzyme A binding pocket [chemical binding]; other site 218491017979 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 8.4e-13 218491017980 lysophospholipid transporter LplT; Provisional; Region: PRK11195 218491017981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491017982 putative substrate translocation pore; other site 218491017983 10 probable transmembrane helices predicted for ECA3640 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 163-185, 220-242, 257-279, 286-303, 308-330, 343-365 and 370-392 218491017984 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 218491017985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218491017986 putative acyl-acceptor binding pocket; other site 218491017987 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 218491017988 acyl-activating enzyme (AAE) consensus motif; other site 218491017989 putative AMP binding site [chemical binding]; other site 218491017990 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.5e-72 218491017991 PS00215 Mitochondrial energy transfer proteins signature. 218491017992 PS00455 AMP-binding domain signature. 218491017993 HMMPfam hit to PF01553, DE Acyltransferase, score 1.9e-24 218491017994 Signal peptide predicted for ECA3642 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.260 between residues 23 and 24; signal peptide 218491017995 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 218491017996 HAMP domain; Region: HAMP; pfam00672 218491017997 dimerization interface [polypeptide binding]; other site 218491017998 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491017999 dimer interface [polypeptide binding]; other site 218491018000 putative CheW interface [polypeptide binding]; other site 218491018001 2 probable transmembrane helices predicted for ECA3642 by TMHMM2.0 at aa 10-32 and 188-210 218491018002 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491018003 HMMPfam hit to PF00672, DE HAMP domain, score 1.3e-12 218491018004 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 6.6e-101 218491018005 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 218491018007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491018008 Coenzyme A binding pocket [chemical binding]; other site 218491018009 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 6.1e-12 218491018010 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 218491018011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491018012 DNA-binding site [nucleotide binding]; DNA binding site 218491018013 FCD domain; Region: FCD; pfam07729 218491018014 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 4.1e-25 218491018015 PS00043 Bacterial regulatory proteins, gntR family signature. 218491018016 Signal peptide predicted for ECA3645 by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.603 between residues 20 and 21; signal peptide 218491018017 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 218491018018 active site 218491018019 P-loop; other site 218491018020 phosphorylation site [posttranslational modification] 218491018021 HMMPfam hit to PF02302, DE PTS system, Lactose/Cellobiose specific IIB subunit, score 3.4e-35 218491018022 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 218491018023 beta-galactosidase; Region: BGL; TIGR03356 218491018024 HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 2e-65 218491018025 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 218491018026 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 218491018027 10 probable transmembrane helices predicted for ECA3647 by TMHMM2.0 at aa 30-52, 72-94, 106-128, 148-166, 186-208, 231-253, 265-282, 292-314, 351-373 and 403-422 218491018028 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218491018029 methionine cluster; other site 218491018030 active site 218491018031 phosphorylation site [posttranslational modification] 218491018032 metal binding site [ion binding]; metal-binding site 218491018033 HMMPfam hit to PF02255, DE PTS system, Lactose/Cellobiose specific IIA subunit, score 1.5e-31 218491018034 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491018035 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491018036 DNA binding site [nucleotide binding] 218491018037 domain linker motif; other site 218491018038 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218491018039 dimerization interface (closed form) [polypeptide binding]; other site 218491018040 ligand binding site [chemical binding]; other site 218491018041 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 5.2e-09 218491018042 Predicted helix-turn-helix motif with score 2013.000, SD 6.04 at aa 2-23, sequence KTMLEVAKRAGVSKATVSRVLN 218491018043 PS00356 Bacterial regulatory proteins, lacI family signature. 218491018044 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 2.6e-08 218491018045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491018046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491018047 non-specific DNA binding site [nucleotide binding]; other site 218491018048 salt bridge; other site 218491018049 sequence-specific DNA binding site [nucleotide binding]; other site 218491018050 Cupin domain; Region: Cupin_2; cl17218 218491018051 HMMPfam hit to PF01381, DE Helix-turn-helix, score 8e-16 218491018052 Predicted helix-turn-helix motif with score 1854.000, SD 5.50 at aa 23-44, sequence LSVTELAKRAGLAKSTLSQLES 218491018053 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218491018054 EamA-like transporter family; Region: EamA; pfam00892 218491018055 EamA-like transporter family; Region: EamA; pfam00892 218491018056 10 probable transmembrane helices predicted for ECA3651 by TMHMM2.0 at aa 7-29, 35-57, 69-88, 93-115, 127-144, 154-171, 178-200, 210-232, 239-261 and 265-287 218491018057 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 7.8e-08 218491018058 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 4e-16 218491018059 diaminopimelate decarboxylase; Provisional; Region: PRK11165 218491018060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 218491018061 active site 218491018062 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491018063 substrate binding site [chemical binding]; other site 218491018064 catalytic residues [active] 218491018065 dimer interface [polypeptide binding]; other site 218491018066 HMMPfam hit to PF00278, DE Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score 3.4e-51 218491018067 HMMPfam hit to PF02784, DE Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 3.2e-78 218491018068 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 218491018069 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 218491018070 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 218491018071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491018072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491018073 dimerization interface [polypeptide binding]; other site 218491018074 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.9e-20 218491018075 Predicted helix-turn-helix motif with score 1944.000, SD 5.81 at aa 19-40, sequence GNLTEAAALLNTSQPTVSRELA 218491018076 PS00044 Bacterial regulatory proteins, lysR family signature. 218491018077 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.6e-44 218491018078 transcriptional activator TtdR; Provisional; Region: PRK09801 218491018079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491018080 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491018081 putative effector binding pocket; other site 218491018082 dimerization interface [polypeptide binding]; other site 218491018083 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.2e-45 218491018084 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1e-12 218491018085 PS00044 Bacterial regulatory proteins, lysR family signature. 218491018086 Predicted helix-turn-helix motif with score 1300.000, SD 3.61 at aa 17-38, sequence GSMIAAAETLDMSRAMVTRYLA 218491018087 Signal peptide predicted for ECA3655 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 24 and 25; signal peptide 218491018088 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 218491018089 HMMPfam hit to PF00753, DE Metallo-beta-lactamase superfamily, score 0.0013 218491018090 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 218491018091 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 218491018092 catalytic residues [active] 218491018093 Signal peptide predicted for ECA3657 by SignalP 2.0 HMM (Signal peptide probabilty 0.701) with cleavage site probability 0.251 between residues 21 and 22; signal peptide 218491018094 1 probable transmembrane helix predicted for ECA3658 by TMHMM2.0 at aa 215-234 218491018095 Protein of unknown function DUF262; Region: DUF262; pfam03235 218491018096 Uncharacterized conserved protein [Function unknown]; Region: COG1479 218491018097 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 218491018098 HMMPfam hit to PF03235, DE Protein of unknown function DUF262, score 3.7e-32 218491018099 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 218491018100 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218491018101 FMN binding site [chemical binding]; other site 218491018102 active site 218491018103 catalytic residues [active] 218491018104 substrate binding site [chemical binding]; other site 218491018105 HMMPfam hit to PF01207, DE Dihydrouridine synthase (Dus), score 3.4e-128 218491018106 PS01136 Uncharacterized protein family UPF0034 signature. 218491018107 phage shock protein G; Reviewed; Region: pspG; PRK09459 218491018108 2 probable transmembrane helices predicted for ECA3661 by TMHMM2.0 at aa 7-29 and 39-61 218491018109 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 218491018110 Cytochrome P450; Region: p450; cl12078 218491018111 HMMPfam hit to PF00067, DE Cytochrome P450, score 3.1e-54 218491018112 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 218491018113 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 218491018114 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 218491018115 NADP binding site [chemical binding]; other site 218491018116 dimer interface [polypeptide binding]; other site 218491018117 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 1.8e-83 218491018118 replicative DNA helicase; Provisional; Region: PRK08006 218491018119 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 218491018120 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 218491018121 Walker A motif; other site 218491018122 ATP binding site [chemical binding]; other site 218491018123 Walker B motif; other site 218491018124 DNA binding loops [nucleotide binding] 218491018125 HMMPfam hit to PF00772, DE DnaB-like helicase N terminal domain, score 8.5e-52 218491018126 HMMPfam hit to PF03796, DE DnaB-like helicase C terminal domain, score 1.9e-134 218491018127 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018128 Predicted helix-turn-helix motif with score 1279.000, SD 3.54 at aa 363-384, sequence RSLKALAKELQVPVVALSQLNR 218491018129 alanine racemase; Reviewed; Region: alr; PRK00053 218491018130 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 218491018131 active site 218491018132 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491018133 substrate binding site [chemical binding]; other site 218491018134 catalytic residues [active] 218491018135 dimer interface [polypeptide binding]; other site 218491018136 HMMPfam hit to PF00842, DE Alanine racemase, C-terminal domain, score 8.6e-176 218491018137 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 218491018138 5 probable transmembrane helices predicted for ECA3666 by TMHMM2.0 at aa 21-43, 61-83, 88-110, 125-144 and 169-191 218491018139 Signal peptide predicted for ECA3667 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.493 between residues 25 and 26; signal peptide 218491018140 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018141 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 218491018142 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 218491018143 putative DNA binding site [nucleotide binding]; other site 218491018144 putative Zn2+ binding site [ion binding]; other site 218491018145 AsnC family; Region: AsnC_trans_reg; pfam01037 218491018146 Predicted helix-turn-helix motif with score 1253.000, SD 3.45 at aa 21-42, sequence LTNQELSELVGLSASQCSRRRI 218491018147 HMMPfam hit to PF01037, DE AsnC family, score 1.1e-22 218491018148 Uncharacterized conserved protein [Function unknown]; Region: COG1284 218491018149 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218491018150 5 probable transmembrane helices predicted for ECA3669 by TMHMM2.0 at aa 30-52, 62-84, 91-110, 125-143 and 176-198 218491018151 HMMPfam hit to PF02588, DE Uncharacterized BCR, YitT family COG1284, score 8.5e-07 218491018152 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 218491018153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491018154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491018155 homodimer interface [polypeptide binding]; other site 218491018156 catalytic residue [active] 218491018157 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 5.4e-87 218491018158 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 218491018159 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491018160 Signal peptide predicted for ECA3673 by SignalP 2.0 HMM (Signal peptide probabilty 0.701) with cleavage site probability 0.605 between residues 47 and 48; signal peptide 218491018161 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 218491018162 2 probable transmembrane helices predicted for ECA3673 by TMHMM2.0 at aa 15-37 and 57-79 218491018163 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 218491018164 3 probable transmembrane helices predicted for ECA3674 by TMHMM2.0 at aa 15-37, 50-72 and 87-109 218491018165 2 probable transmembrane helices predicted for ECA3675 by TMHMM2.0 at aa 190-209 and 224-246 218491018166 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018167 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 218491018168 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 218491018169 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 218491018170 PS00019 Actinin-type actin-binding domain signature 1. 218491018171 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018172 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09675 218491018173 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 218491018174 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 218491018175 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 218491018176 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 218491018177 oligomeric interface; other site 218491018178 putative active site [active] 218491018179 homodimer interface [polypeptide binding]; other site 218491018180 HMMPfam hit to PF01850, DE PIN domain, score 3.3e-13 218491018181 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 218491018182 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 218491018183 HMMPfam hit to PF01894, DE Uncharacterised protein family UPF0047, score 4.9e-56 218491018184 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 218491018185 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 218491018186 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 218491018187 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 218491018188 HMMPfam hit to PF00005, DE ABC transporter, score 6.5e-36 218491018189 PS00211 ABC transporters family signature. 218491018190 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018191 HMMPfam hit to PF00005, DE ABC transporter, score 4.4e-06 218491018192 PS00211 ABC transporters family signature. 218491018193 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018194 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 218491018195 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218491018196 dimer interface [polypeptide binding]; other site 218491018197 ssDNA binding site [nucleotide binding]; other site 218491018198 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218491018199 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 218491018200 HMMPfam hit to PF00436, DE Single-strand binding protein family, score 1.5e-64 218491018201 PS00735 Single-strand binding protein family signature 1. 218491018202 PS00736 Single-strand binding protein family signature 2. 218491018203 Signal peptide predicted for ECA3691 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.938 between residues 28 and 29; signal peptide 218491018204 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 218491018205 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 218491018206 active site 218491018207 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018208 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218491018209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491018210 Coenzyme A binding pocket [chemical binding]; other site 218491018211 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 1.7e-16 218491018212 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 218491018213 Uncharacterized conserved protein [Function unknown]; Region: COG2128 218491018214 prophage ECA41 218491018215 Mor transcription activator family; Region: Mor; pfam08765 218491018216 Predicted helix-turn-helix motif with score 1668.000, SD 4.87 at aa 81-102, sequence RNHHDLARKYGVSLQWVYSVIK 218491018217 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 218491018218 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 218491018219 metal binding site [ion binding]; metal-binding site 218491018220 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 218491018221 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 218491018222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491018223 Walker A/P-loop; other site 218491018224 ATP binding site [chemical binding]; other site 218491018225 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018226 Predicted helix-turn-helix motif with score 1323.000, SD 3.69 at aa 13-34, sequence LSQAVVARHIAVSEATLAQIVN 218491018227 Integrase core domain; Region: rve; pfam00665 218491018228 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 218491018229 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018230 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 218491018231 Predicted helix-turn-helix motif with score 1221.000, SD 3.35 at aa 28-49, sequence VSNGELAAALDDSPANVNRALN 218491018232 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 218491018233 Predicted helix-turn-helix motif with score 1979.000, SD 5.93 at aa 15-36, sequence ITITQWAQENGYSREAVYRVLN 218491018234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 218491018235 sequence-specific DNA binding site [nucleotide binding]; other site 218491018236 salt bridge; other site 218491018237 Predicted helix-turn-helix motif with score 1428.000, SD 4.05 at aa 16-37, sequence FSQADFAELVGASRKSQIRWEK 218491018238 2 probable transmembrane helices predicted for ECA3709 by TMHMM2.0 at aa 87-109 and 124-143 218491018239 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018240 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218491018241 Nucleoid-associated protein [General function prediction only]; Region: COG3081 218491018242 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 218491018243 Moulting cycle; Region: Moulting_cycle; pfam04870 218491018244 2 probable transmembrane helices predicted for ECA3712 by TMHMM2.0 at aa 286-308 and 357-379 218491018245 Signal peptide predicted for ECA3713 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.733 between residues 31 and 32; signal peptide 218491018246 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 218491018247 3 probable transmembrane helices predicted for ECA3713 by TMHMM2.0 at aa 13-32, 37-56 and 91-113 218491018248 Signal peptide predicted for ECA3714 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.614 between residues 31 and 32; signal peptide 218491018249 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491018250 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491018251 catalytic residue [active] 218491018252 1 probable transmembrane helix predicted for ECA3714 by TMHMM2.0 at aa 13-32 218491018253 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 2.4e-12 218491018254 Signal peptide predicted for ECA3715 by SignalP 2.0 HMM (Signal peptide probabilty 0.666) with cleavage site probability 0.337 between residues 38 and 39; signal peptide 218491018255 Signal peptide predicted for ECA3716 by SignalP 2.0 HMM (Signal peptide probabilty 0.843) with cleavage site probability 0.759 between residues 23 and 24; signal peptide 218491018256 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 218491018257 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 218491018258 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 218491018259 Protein of unknown function (DUF935); Region: DUF935; pfam06074 218491018260 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 218491018261 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 218491018262 Signal peptide predicted for ECA3725 by SignalP 2.0 HMM (Signal peptide probabilty 0.858) with cleavage site probability 0.719 between residues 20 and 21; signal peptide 218491018263 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 218491018264 Gp37 protein; Region: Gp37; pfam09646 218491018265 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 218491018266 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 218491018267 Phage tail tube protein FII; Region: Phage_tube; cl01390 218491018268 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 218491018269 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 218491018270 2 probable transmembrane helices predicted for ECA3732 by TMHMM2.0 at aa 577-599 and 620-642 218491018271 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 218491018272 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 218491018273 Phage protein D [General function prediction only]; Region: COG3500 218491018274 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 218491018275 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 218491018276 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 218491018277 Baseplate J-like protein; Region: Baseplate_J; cl01294 218491018278 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 218491018279 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 218491018280 Phage Tail Collar Domain; Region: Collar; pfam07484 218491018281 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 218491018282 HMMPfam hit to PF02413, DE Caudovirales tail fibre assembly protein, score 1.1e-21 218491018283 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491018284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491018285 DNA-binding site [nucleotide binding]; DNA binding site 218491018286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491018287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491018288 homodimer interface [polypeptide binding]; other site 218491018289 catalytic residue [active] 218491018290 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 2.9e-05 218491018291 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491018292 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491018293 DNA binding site [nucleotide binding] 218491018294 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 218491018295 ligand binding site [chemical binding]; other site 218491018296 dimerization interface [polypeptide binding]; other site 218491018297 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.0003 218491018298 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 1.3e-09 218491018299 Predicted helix-turn-helix motif with score 2268.000, SD 6.91 at aa 2-23, sequence ATLKDIADRAGVSISTVSRALN 218491018300 PS00356 Bacterial regulatory proteins, lacI family signature. 218491018301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218491018302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491018303 dimer interface [polypeptide binding]; other site 218491018304 conserved gate region; other site 218491018305 putative PBP binding loops; other site 218491018306 ABC-ATPase subunit interface; other site 218491018307 6 probable transmembrane helices predicted for ECA3746 by TMHMM2.0 at aa 22-44, 150-172, 183-205, 215-237, 258-280 and 314-336 218491018308 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3.2e-20 218491018309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 218491018310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491018311 ABC-ATPase subunit interface; other site 218491018312 putative PBP binding loops; other site 218491018313 6 probable transmembrane helices predicted for ECA3747 by TMHMM2.0 at aa 38-60, 111-133, 146-165, 194-216, 237-259 and 302-324 218491018314 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.5e-14 218491018315 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491018316 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218491018317 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218491018318 Walker A/P-loop; other site 218491018319 ATP binding site [chemical binding]; other site 218491018320 Q-loop/lid; other site 218491018321 ABC transporter signature motif; other site 218491018322 Walker B; other site 218491018323 D-loop; other site 218491018324 H-loop/switch region; other site 218491018325 TOBE domain; Region: TOBE_2; pfam08402 218491018326 HMMPfam hit to PF00005, DE ABC transporter, score 3.3e-60 218491018327 PS00211 ABC transporters family signature. 218491018328 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018329 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 218491018330 Signal peptide predicted for ECA3751 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 24 and 25; signal peptide 218491018331 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 218491018332 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 218491018333 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 4.1e-14 218491018334 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 218491018335 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 218491018336 Signal peptide predicted for ECA3754 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.745 between residues 29 and 30; signal peptide 218491018337 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 218491018338 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 218491018339 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 2.7e-14 218491018340 2 probable transmembrane helices predicted for ECA3755 by TMHMM2.0 at aa 96-118 and 123-142 218491018341 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218491018342 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 218491018343 HMMPfam hit to PF00005, DE ABC transporter, score 8.6e-37 218491018344 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018345 PS00211 ABC transporters family signature. 218491018346 Signal peptide predicted for ECA3757 by SignalP 2.0 HMM (Signal peptide probabilty 0.664) with cleavage site probability 0.552 between residues 31 and 32; signal peptide 218491018347 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218491018348 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491018349 ABC-ATPase subunit interface; other site 218491018350 dimer interface [polypeptide binding]; other site 218491018351 putative PBP binding regions; other site 218491018352 HMMPfam hit to PF00950, DE ABC 3 transport family, score 6e-46 218491018353 7 probable transmembrane helices predicted for ECA3757 by TMHMM2.0 at aa 15-37, 58-80, 100-122, 142-164, 184-206, 226-248 and 258-280 218491018354 Signal peptide predicted for ECA3758 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22; signal peptide 218491018355 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 218491018356 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 218491018357 metal binding site [ion binding]; metal-binding site 218491018358 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01297, DE Periplasmic solute binding protein family, score 7.9e-86 218491018359 PS00881 Protein splicing signature. 218491018360 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218491018361 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218491018362 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218491018363 HMMPfam hit to PF00455, DE Bacterial regulatory proteins, deoR family, score 4.8e-69 218491018364 PS00894 Bacterial regulatory proteins, deoR family signature. 218491018365 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 218491018366 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 218491018367 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 218491018369 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 218491018370 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 218491018371 putative active site [active] 218491018372 metal binding site [ion binding]; metal-binding site 218491018373 HMMPfam hit to PF00465, DE Iron-containing alcohol dehydrogenase, score 1.3e-59 218491018374 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 218491018375 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 218491018376 inhibitor site; inhibition site 218491018377 active site 218491018378 dimer interface [polypeptide binding]; other site 218491018379 catalytic residue [active] 218491018380 HMMPfam hit to PF00701, DE Dihydrodipicolinate synthetase family, score 2.1e-57 218491018381 PS00666 Dihydrodipicolinate synthetase signature 2. 218491018382 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 218491018383 Na binding site [ion binding]; other site 218491018384 13 probable transmembrane helices predicted for ECA3764 by TMHMM2.0 at aa 10-28, 41-60, 75-97, 126-148, 153-172, 179-201, 229-251, 263-285, 315-337, 358-377, 382-404, 409-428 and 432-449 218491018385 HMMPfam hit to PF00474, DE Sodium:solute symporter family, score 1.7e-05 218491018386 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491018387 BNR repeat-like domain; Region: BNR_2; pfam13088 218491018388 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 218491018389 Asp-box motif; other site 218491018390 HMMPfam hit to PF02012, DE BNR/Asp-box repeat, score 47 218491018391 HMMPfam hit to PF02012, DE BNR/Asp-box repeat, score 2.9 218491018392 HMMPfam hit to PF02012, DE BNR/Asp-box repeat, score 0.26 218491018393 HMMPfam hit to PF02012, DE BNR/Asp-box repeat, score 6.5 218491018394 Domain of unknown function (DUF386); Region: DUF386; cl01047 218491018395 short chain dehydrogenase; Provisional; Region: PRK07577 218491018396 classical (c) SDRs; Region: SDR_c; cd05233 218491018397 NAD(P) binding site [chemical binding]; other site 218491018398 active site 218491018399 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 2e-35 218491018400 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 218491018401 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 218491018402 dimer interface [polypeptide binding]; other site 218491018403 active site 218491018404 glycine loop; other site 218491018405 HMMPfam hit to PF02901, DE Pyruvate formate lyase, score 3.9e-53 218491018406 HMMPfam hit to PF01228, DE Glycine radical, score 2.4e-06 218491018407 PS00850 Glycine radical signature. 218491018408 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 218491018409 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 218491018410 HMMPfam hit to PF02143, , score 2.6e-11 218491018411 PS01087 Radical activating enzymes signature. 218491018412 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00013 218491018413 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491018414 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.00093 218491018415 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491018416 Signal peptide predicted for ECA3770 by SignalP 2.0 HMM (Signal peptide probabilty 0.854) with cleavage site probability 0.366 between residues 20 and 21; signal peptide 218491018417 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 218491018418 HMMPfam hit to PF00893, DE Small Multidrug Resistance protein, score 9.3e-21 218491018419 3 probable transmembrane helices predicted for ECA3770 by TMHMM2.0 at aa 37-54, 63-85 and 95-112 218491018420 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 218491018421 HMMPfam hit to PF00893, DE Small Multidrug Resistance protein, score 3.3e-28 218491018422 4 probable transmembrane helices predicted for ECA3771 by TMHMM2.0 at aa 5-22, 35-52, 57-79 and 86-105 218491018423 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491018424 DNA binding site [nucleotide binding] 218491018425 domain linker motif; other site 218491018426 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491018427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491018428 DNA binding site [nucleotide binding] 218491018429 domain linker motif; other site 218491018430 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 218491018431 putative dimerization interface [polypeptide binding]; other site 218491018432 putative ligand binding site [chemical binding]; other site 218491018433 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.00046 218491018434 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 8.8e-08 218491018435 Predicted helix-turn-helix motif with score 1871.000, SD 5.56 at aa 12-92, sequence VTLQDVADYAGVGTMTVSRVMRKPDLVSDKLRSKVELAARTLGYEPNQEASLLTESA NRVTLQDIANHAGVGVMTVSRALR 218491018436 Predicted helix-turn-helix motif with score 1871.000, SD 5.56 at aa 71-92, sequence VTLQDIANHAGVGVMTVSRALR 218491018437 PS00356 Bacterial regulatory proteins, lacI family signature. 218491018438 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 7e-08 218491018439 Predicted helix-turn-helix motif with score 1832.000, SD 5.43 at aa 12-33, sequence VTLQDVADYAGVGTMTVSRVMR 218491018440 PS00356 Bacterial regulatory proteins, lacI family signature. 218491018441 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218491018442 active site 218491018443 phosphorylation site [posttranslational modification] 218491018444 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00359, DE Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 3.6e-39 218491018445 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218491018446 active site 218491018447 P-loop; other site 218491018448 phosphorylation site [posttranslational modification] 218491018449 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 218491018450 10 probable transmembrane helices predicted for ECA3775 by TMHMM2.0 at aa 6-28, 48-70, 93-112, 119-141, 145-167, 224-246, 256-275, 316-338, 342-364 and 371-393 218491018451 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 218491018452 active site 218491018453 intersubunit interactions; other site 218491018454 catalytic residue [active] 218491018455 HMMPfam hit to PF00923, DE Transaldolase, score 5.1e-76 218491018456 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491018457 PS01054 Transaldolase signature 1. 218491018458 PS00958 Transaldolase active site. 218491018459 hypothetical protein; Provisional; Region: PRK05248 218491018460 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 218491018461 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 218491018462 substrate binding site [chemical binding]; other site 218491018463 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 218491018464 substrate binding site [chemical binding]; other site 218491018465 ligand binding site [chemical binding]; other site 218491018466 HMMPfam hit to PF00330, DE Aconitase family (aconitate hydratase), score 3.4e-07 218491018467 PS01244 Aconitase family signature 2. 218491018468 PS00450 Aconitase family signature 1. 218491018469 Signal peptide predicted for ECA3779 by SignalP 2.0 HMM (Signal peptide probabilty 0.852) with cleavage site probability 0.851 between residues 43 and 44; signal peptide 218491018470 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 218491018471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491018472 dimerization interface [polypeptide binding]; other site 218491018473 putative DNA binding site [nucleotide binding]; other site 218491018474 putative Zn2+ binding site [ion binding]; other site 218491018475 HMMPfam hit to PF01022, DE Bacterial regulatory protein, arsR family, score 4e-21 218491018476 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 43-64, sequence MSVGALLEHIPLSQSALSQHLA 218491018477 outer membrane receptor FepA; Provisional; Region: PRK13524 218491018478 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491018479 N-terminal plug; other site 218491018480 ligand-binding site [chemical binding]; other site 218491018481 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 4.1e-30 218491018482 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491018483 PS00070 Aldehyde dehydrogenases cysteine active site. 218491018484 PS00449 ATP synthase a subunit signature. 218491018485 PS00430 TonB-dependent receptor proteins signature 1. 218491018486 arginine decarboxylase; Region: PLN02439 218491018487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491018488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491018489 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 4.6e-06 218491018490 Predicted helix-turn-helix motif with score 2266.000, SD 6.90 at aa 242-263, sequence LSMSEIAKSVNMSESTLQRHFR 218491018491 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.00054 218491018492 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 218491018493 HMMPfam hit to PF03972, DE MmgE/PrpD family, score 2.2e-38 218491018494 Signal peptide predicted for ECA3785 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.967 between residues 24 and 25; signal peptide 218491018495 Abhydrolase family; Region: Abhydrolase_7; pfam12715 218491018496 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 218491018497 Signal peptide predicted for ECA3787 by SignalP 2.0 HMM (Signal peptide probabilty 0.663) with cleavage site probability 0.527 between residues 26 and 27; signal peptide 218491018498 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 218491018499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491018500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491018501 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218491018502 HMMPfam hit to PF02852, DE Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 1.1e-50 218491018503 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 5.8e-97 218491018504 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218491018505 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 218491018506 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218491018507 E3 interaction surface; other site 218491018508 lipoyl attachment site [posttranslational modification]; other site 218491018509 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218491018510 E3 interaction surface; other site 218491018511 lipoyl attachment site [posttranslational modification]; other site 218491018512 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218491018513 E3 interaction surface; other site 218491018514 lipoyl attachment site [posttranslational modification]; other site 218491018515 e3 binding domain; Region: E3_binding; pfam02817 218491018516 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218491018517 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00198, DE 2-oxoacid dehydrogenases acyltransferase (catalytic domain), score 7.8e-109 218491018518 HMMPfam hit to PF02817, DE e3 binding domain, score 4.4e-18 218491018519 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 2.6e-27 218491018520 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218491018521 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 9.9e-30 218491018522 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218491018523 HMMPfam hit to PF00364, DE Biotin-requiring enzyme, score 1.3e-28 218491018524 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218491018525 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 218491018526 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 218491018527 dimer interface [polypeptide binding]; other site 218491018528 TPP-binding site [chemical binding]; other site 218491018529 HMMPfam hit to PF00456, DE Transketolase, thiamine diphosphate binding domain, score 3.2e-06 218491018530 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 218491018531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491018532 DNA-binding site [nucleotide binding]; DNA binding site 218491018533 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218491018534 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 2.1e-32 218491018535 PS00043 Bacterial regulatory proteins, gntR family signature. 218491018536 Predicted helix-turn-helix motif with score 1327.000, SD 3.71 at aa 35-56, sequence PPERELAKQFDVSRPSLREAIQ 218491018537 aromatic amino acid transporter; Provisional; Region: PRK10238 218491018538 HMMPfam hit to PF00324, DE Amino acid permease, score 4.6e-208 218491018539 12 probable transmembrane helices predicted for ECA3791 by TMHMM2.0 at aa 21-40, 44-61, 99-121, 126-148, 153-175, 198-220, 240-262, 282-304, 331-353, 357-379, 399-421 and 426-445 218491018540 PS00218 Amino acid permeases signature. 218491018541 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218491018542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491018543 putative substrate translocation pore; other site 218491018544 12 probable transmembrane helices predicted for ECA3792 by TMHMM2.0 at aa 12-34, 39-61, 82-99, 109-131, 152-174, 184-201, 234-256, 266-285, 298-317, 322-344, 365-387 and 407-429 218491018545 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 218491018546 active site 218491018547 regulatory protein AmpE; Provisional; Region: PRK10987 218491018548 4 probable transmembrane helices predicted for ECA3794 by TMHMM2.0 at aa 38-60, 65-87, 146-168 and 266-283 218491018549 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 218491018550 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 218491018551 amidase catalytic site [active] 218491018552 substrate binding site [chemical binding]; other site 218491018553 Zn binding residues [ion binding]; other site 218491018554 HMMPfam hit to PF01510, DE N-acetylmuramoyl-L-alanine amidase, score 1.8e-53 218491018555 Signal peptide predicted for ECA3796 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 25 and 26; signal peptide 218491018556 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 218491018557 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018558 HMMPfam hit to PF03502, DE Nucleoside-specific channel-forming protein, Tsx, score 4e-88 218491018559 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 218491018560 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 218491018561 dimerization interface [polypeptide binding]; other site 218491018562 active site 218491018563 HMMPfam hit to PF02749, DE Quinolinate phosphoribosyl transferase, N-terminal domain, score 3.4e-33 218491018564 HMMPfam hit to PF01729, DE Quinolinate phosphoribosyl transferase, C-terminal domain, score 3.8e-93 218491018565 putative major pilin subunit; Provisional; Region: PRK10574 218491018566 Signal peptide predicted for ECA3798 by SignalP 2.0 HMM (Signal peptide probabilty 0.619) with cleavage site probability 0.259 between residues 26 and 27; signal peptide 218491018567 Pilin (bacterial filament); Region: Pilin; pfam00114 218491018568 PS00409 Prokaryotic N-terminal methylation site. 218491018569 HMMPfam hit to PF00114, DE Pilin (bacterial filament), score 1.7e-06 218491018570 1 probable transmembrane helix predicted for ECA3798 by TMHMM2.0 at aa 7-29 218491018571 hypothetical protein; Provisional; Region: PRK10436 218491018572 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 218491018573 Walker A motif; other site 218491018574 ATP binding site [chemical binding]; other site 218491018575 Walker B motif; other site 218491018576 HMMPfam hit to PF00437, DE Type II/IV secretion system protein, score 2.9e-159 218491018577 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018578 PS00662 Bacterial type II secretion system protein E signature. 218491018579 type IV pilin biogenesis protein; Provisional; Region: PRK10573 218491018580 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218491018581 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218491018582 HMMPfam hit to PF00482, DE Bacterial type II secretion system protein F domain, score 1.4e-96 218491018583 PS00874 Bacterial type II secretion system protein F signature. 218491018584 3 probable transmembrane helices predicted for ECA3800 by TMHMM2.0 at aa 164-186, 213-235 and 370-392 218491018585 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 218491018586 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 218491018587 active site 218491018588 HMMPfam hit to PF00478, DE IMP dehydrogenase / GMP reductase domain, score 1.2e-101 218491018589 PS00487 IMP dehydrogenase / GMP reductase signature. 218491018590 HMMPfam hit to PF01574, , score 0.00039 218491018591 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 218491018592 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 218491018593 CoA-binding site [chemical binding]; other site 218491018594 ATP-binding [chemical binding]; other site 218491018595 HMMPfam hit to PF01121, DE Dephospho-CoA kinase, score 5.7e-93 218491018596 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018597 PS01294 Uncharacterized protein family UPF0038 signature. 218491018598 hypothetical protein; Provisional; Region: PRK05287 218491018599 DNA gyrase inhibitor; Reviewed; Region: PRK00418 218491018600 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03884, DE Domain of unknown function (DUF329), score 1.7e-24 218491018601 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 218491018602 active site 218491018603 8-oxo-dGMP binding site [chemical binding]; other site 218491018604 nudix motif; other site 218491018605 metal binding site [ion binding]; metal-binding site 218491018606 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00293, DE NUDIX domain, score 1.6e-26 218491018607 PS00893 mutT domain signature. 218491018608 Predicted helix-turn-helix motif with score 1206.000, SD 3.29 at aa 1-22, sequence MTQKQLSVAVGIIRNTEQQYFI 218491018609 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 218491018610 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 218491018611 SEC-C motif; Region: SEC-C; pfam02810 218491018612 HMMPfam hit to PF02810, DE SEC-C motif, score 6e-10 218491018613 PS01312 Protein secA signatures. 218491018614 HMMPfam hit to PF01043, DE SecA protein, amino terminal region, score 0 218491018615 Signal peptide predicted for ECA3807 by SignalP 2.0 HMM (Signal peptide probabilty 0.946) with cleavage site probability 0.405 between residues 36 and 37; signal peptide 218491018616 SecA regulator SecM; Provisional; Region: PRK02943 218491018617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 218491018618 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 218491018619 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 218491018620 HMMPfam hit to PF03331, DE UDP-3-O-acyl N-acetylglycosamine deacetylase, score 1.8e-185 218491018621 cell division protein FtsZ; Validated; Region: PRK09330 218491018622 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 218491018623 nucleotide binding site [chemical binding]; other site 218491018624 SulA interaction site; other site 218491018625 HMMPfam hit to PF03953, DE Tubulin/FtsZ family, C-terminal domain, score 3.5e-44 218491018626 HMMPfam hit to PF00091, DE Tubulin/FtsZ family, GTPase domain, score 1e-88 218491018627 PS01135 FtsZ protein signature 2. 218491018628 PS01134 FtsZ protein signature 1. 218491018629 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 218491018630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 218491018631 Cell division protein FtsA; Region: FtsA; pfam14450 218491018632 HMMPfam hit to PF02491, DE Cell division protein FtsA, score 4.1e-67 218491018633 HMMPfam hit to PF02491, DE Cell division protein FtsA, score 1.7e-71 218491018634 cell division protein FtsQ; Provisional; Region: PRK10775 218491018635 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 218491018636 Cell division protein FtsQ; Region: FtsQ; pfam03799 218491018637 HMMPfam hit to PF03799, DE Cell division protein FtsQ, score 8e-56 218491018638 1 probable transmembrane helix predicted for ECA3812 by TMHMM2.0 at aa 31-53 218491018639 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 218491018640 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 218491018641 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 218491018642 HMMPfam hit to PF01820, DE D-ala D-ala ligase, score 2.9e-144 218491018643 PS00844 D-alanine--D-alanine ligase signature 2. 218491018644 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491018645 PS00843 D-alanine--D-alanine ligase signature 1. 218491018646 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 218491018647 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218491018648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218491018649 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218491018650 HMMPfam hit to PF02875, DE Mur ligase family, glutamate ligase domain, score 5.3e-24 218491018651 HMMPfam hit to PF01225, DE Mur ligase family, catalytic domain, score 9.7e-69 218491018652 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 218491018653 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 218491018654 active site 218491018655 homodimer interface [polypeptide binding]; other site 218491018656 HMMPfam hit to PF03033, DE Glycosyltransferase family 28 N-terminal domain, score 2.8e-131 218491018657 cell division protein FtsW; Provisional; Region: PRK10774 218491018658 HMMPfam hit to PF01098, DE Cell cycle protein, score 4.2e-171 218491018659 8 probable transmembrane helices predicted for ECA3816 by TMHMM2.0 at aa 35-57, 72-89, 96-118, 170-192, 205-227, 293-315, 327-349 and 359-381 218491018660 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 218491018661 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 218491018662 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218491018663 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218491018664 HMMPfam hit to PF02875, DE Mur ligase family, glutamate ligase domain, score 8.7e-13 218491018665 HMMPfam hit to PF01225, DE Mur ligase family, catalytic domain, score 2.7e-56 218491018666 PS00012 Phosphopantetheine attachment site. 218491018667 1 probable transmembrane helix predicted for ECA3817 by TMHMM2.0 at aa 9-31 218491018668 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018669 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 218491018670 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 218491018671 Mg++ binding site [ion binding]; other site 218491018672 putative catalytic motif [active] 218491018673 putative substrate binding site [chemical binding]; other site 218491018674 10 probable transmembrane helices predicted for ECA3818 by TMHMM2.0 at aa 26-48, 69-91, 95-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 218491018675 HMMPfam hit to PF00953, DE Glycosyl transferase, score 1.9e-85 218491018676 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 218491018677 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218491018678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218491018679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218491018680 HMMPfam hit to PF02875, DE Mur ligase family, glutamate ligase domain, score 7.1e-17 218491018681 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491018682 HMMPfam hit to PF01225, DE Mur ligase family, catalytic domain, score 1.2e-67 218491018683 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 218491018684 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218491018685 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218491018686 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218491018687 HMMPfam hit to PF02875, DE Mur ligase family, glutamate ligase domain, score 2.7e-38 218491018688 HMMPfam hit to PF01225, DE Mur ligase family, catalytic domain, score 1.7e-77 218491018689 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 218491018690 Signal peptide predicted for ECA3821 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.664 between residues 41 and 42; signal peptide 218491018691 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218491018692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218491018693 HMMPfam hit to PF00905, DE Penicillin binding protein transpeptidase domain, score 3.1e-130 218491018694 HMMPfam hit to PF03717, DE Penicillin-binding Protein dimerisation domain, score 5.9e-60 218491018695 1 probable transmembrane helix predicted for ECA3821 by TMHMM2.0 at aa 21-43 218491018696 cell division protein FtsL; Provisional; Region: PRK10772 218491018697 1 probable transmembrane helix predicted for ECA3822 by TMHMM2.0 at aa 21-43 218491018698 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 218491018699 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 218491018700 HMMPfam hit to PF01795, DE MraW methylase family, score 1e-176 218491018701 cell division protein MraZ; Reviewed; Region: PRK00326 218491018702 MraZ protein; Region: MraZ; pfam02381 218491018703 MraZ protein; Region: MraZ; pfam02381 218491018704 HMMPfam hit to PF02381, DE Domain of unknown function UPF0040 family, score 5.2e-22 218491018705 HMMPfam hit to PF02381, DE Domain of unknown function UPF0040 family, score 9.1e-27 218491018706 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 218491018707 3 probable transmembrane helices predicted for ECA3826 by TMHMM2.0 at aa 15-37, 87-106 and 111-133 218491018708 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 218491018709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491018710 DNA binding site [nucleotide binding] 218491018711 domain linker motif; other site 218491018712 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 218491018713 dimerization interface [polypeptide binding]; other site 218491018714 ligand binding site [chemical binding]; other site 218491018715 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.0001 218491018716 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 1.4e-06 218491018717 Predicted helix-turn-helix motif with score 1821.000, SD 5.39 at aa 1-22, sequence MKLDEIARLAGVSRTTASYVIN 218491018718 PS00356 Bacterial regulatory proteins, lacI family signature. 218491018719 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 218491018720 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 218491018721 putative valine binding site [chemical binding]; other site 218491018722 dimer interface [polypeptide binding]; other site 218491018723 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 218491018724 HMMPfam hit to PF01842, DE ACT domain, score 3.4e-16 218491018725 PS00430 TonB-dependent receptor proteins signature 1. 218491018726 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 218491018727 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491018728 PYR/PP interface [polypeptide binding]; other site 218491018729 dimer interface [polypeptide binding]; other site 218491018730 TPP binding site [chemical binding]; other site 218491018731 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491018732 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218491018733 TPP-binding site [chemical binding]; other site 218491018734 dimer interface [polypeptide binding]; other site 218491018735 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 5.1e-90 218491018736 PS00187 Thiamine pyrophosphate enzymes signature. 218491018737 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 4.4e-70 218491018738 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 3.4e-100 218491018739 PS00044 Bacterial regulatory proteins, lysR family signature. 218491018740 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 218491018741 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491018742 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 218491018743 acyl-activating enzyme (AAE) consensus motif; other site 218491018744 putative AMP binding site [chemical binding]; other site 218491018745 putative active site [active] 218491018746 putative CoA binding site [chemical binding]; other site 218491018747 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 5.8e-81 218491018748 PS00455 AMP-binding domain signature. 218491018749 2-isopropylmalate synthase; Validated; Region: PRK00915 218491018750 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 218491018751 active site 218491018752 catalytic residues [active] 218491018753 metal binding site [ion binding]; metal-binding site 218491018754 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 218491018755 HMMPfam hit to PF00682, DE HMGL-like, score 7.3e-148 218491018756 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 218491018757 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 218491018758 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 218491018759 tartrate dehydrogenase; Region: TTC; TIGR02089 218491018760 HMMPfam hit to PF00180, DE Isocitrate/isopropylmalate dehydrogenase, score 2.2e-214 218491018761 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018762 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 218491018763 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 218491018764 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 218491018765 substrate binding site [chemical binding]; other site 218491018766 ligand binding site [chemical binding]; other site 218491018767 HMMPfam hit to PF00330, DE Aconitase family (aconitate hydratase), score 3.1e-271 218491018768 PS00450 Aconitase family signature 1. 218491018769 PS01244 Aconitase family signature 2. 218491018770 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 218491018771 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 218491018772 substrate binding site [chemical binding]; other site 218491018773 HMMPfam hit to PF00694, DE Aconitase C-terminal domain, score 2.9e-86 218491018774 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 218491018775 3 probable transmembrane helices predicted for ECA3835 by TMHMM2.0 at aa 4-21, 41-60 and 80-102 218491018776 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 218491018777 6 probable transmembrane helices predicted for ECA3836 by TMHMM2.0 at aa 21-43, 58-77, 82-104, 143-165, 186-208 and 218-240 218491018778 HMMPfam hit to PF03591, DE AzlC protein, score 2.7e-54 218491018779 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 218491018780 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491018781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491018782 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 2.1e-08 218491018783 PS00041 Bacterial regulatory proteins, araC family signature. 218491018784 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 8.3e-05 218491018785 Tar ligand binding domain homologue; Region: TarH; pfam02203 218491018786 dimer interface [polypeptide binding]; other site 218491018787 ligand binding site [chemical binding]; other site 218491018788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491018789 dimerization interface [polypeptide binding]; other site 218491018790 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491018791 dimer interface [polypeptide binding]; other site 218491018792 putative CheW interface [polypeptide binding]; other site 218491018793 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 3.9e-94 218491018794 HMMPfam hit to PF00672, DE HAMP domain, score 3.4e-08 218491018795 2 probable transmembrane helices predicted for ECA3838 by TMHMM2.0 at aa 33-55 and 212-234 218491018796 PS00237 G-protein coupled receptors signature. 218491018797 transcriptional regulator SgrR; Provisional; Region: PRK13626 218491018798 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 218491018799 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 218491018800 Predicted helix-turn-helix motif with score 1233.000, SD 3.39 at aa 24-45, sequence TTLQELTGVLNCSRRHIRSLLN 218491018801 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 6.2e-05 218491018802 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 218491018803 NmrA-like family; Region: NmrA; pfam05368 218491018804 NAD(P) binding site [chemical binding]; other site 218491018805 active site lysine 218491018806 HMMPfam hit to PF02716, DE Isoflavone reductase, score 1.4e-05 218491018807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491018808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491018809 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 218491018810 putative effector binding pocket; other site 218491018811 putative dimerization interface [polypeptide binding]; other site 218491018812 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 9.6e-18 218491018813 Predicted helix-turn-helix motif with score 1609.000, SD 4.67 at aa 17-38, sequence GSFKKAAETLHVLPSTVTRSIK 218491018814 PS00044 Bacterial regulatory proteins, lysR family signature. 218491018815 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 9.5e-53 218491018816 Signal peptide predicted for ECA3844 by SignalP 2.0 HMM (Signal peptide probabilty 0.858) with cleavage site probability 0.857 between residues 45 and 46; signal peptide 218491018817 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 218491018818 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 218491018819 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 1.3e-11 218491018820 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 218491018821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491018822 dimer interface [polypeptide binding]; other site 218491018823 conserved gate region; other site 218491018824 putative PBP binding loops; other site 218491018825 ABC-ATPase subunit interface; other site 218491018826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491018827 dimer interface [polypeptide binding]; other site 218491018828 conserved gate region; other site 218491018829 putative PBP binding loops; other site 218491018830 ABC-ATPase subunit interface; other site 218491018831 12 probable transmembrane helices predicted for ECA3845 by TMHMM2.0 at aa 20-42, 62-84, 96-118, 141-163, 205-227, 247-264, 296-318, 338-360, 377-399, 409-428, 465-487 and 507-529 218491018832 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0052 218491018833 Predicted helix-turn-helix motif with score 1085.000, SD 2.88 at aa 171-192, sequence TEQRQLAANLGMNSWQHFRLLE 218491018834 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018835 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 218491018836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491018837 Walker A/P-loop; other site 218491018838 ATP binding site [chemical binding]; other site 218491018839 Q-loop/lid; other site 218491018840 ABC transporter signature motif; other site 218491018841 Walker B; other site 218491018842 D-loop; other site 218491018843 H-loop/switch region; other site 218491018844 HMMPfam hit to PF00005, DE ABC transporter, score 6.1e-63 218491018845 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018846 PS00211 ABC transporters family signature. 218491018847 Signal peptide predicted for ECA3847 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.825 between residues 27 and 28; signal peptide 218491018848 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 218491018849 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 218491018850 active site 218491018851 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 218491018852 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491018853 PYR/PP interface [polypeptide binding]; other site 218491018854 dimer interface [polypeptide binding]; other site 218491018855 TPP binding site [chemical binding]; other site 218491018856 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491018857 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218491018858 TPP-binding site [chemical binding]; other site 218491018859 dimer interface [polypeptide binding]; other site 218491018860 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 1.4e-100 218491018861 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 1.1e-61 218491018862 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 3.5e-88 218491018863 PS00187 Thiamine pyrophosphate enzymes signature. 218491018864 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 218491018865 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 218491018866 putative valine binding site [chemical binding]; other site 218491018867 dimer interface [polypeptide binding]; other site 218491018868 HMMPfam hit to PF01842, DE ACT domain, score 1.2e-10 218491018869 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218491018870 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 218491018871 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 218491018872 5 probable transmembrane helices predicted for ECA3850 by TMHMM2.0 at aa 13-35, 55-77, 140-162, 177-199 and 219-238 218491018873 HMMPfam hit to PF00597, DE DedA family, score 7.8e-45 218491018874 Signal peptide predicted for ECA3851 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.812 between residues 36 and 37; signal peptide 218491018875 Cache domain; Region: Cache_1; pfam02743 218491018876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491018877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491018878 metal binding site [ion binding]; metal-binding site 218491018879 active site 218491018880 I-site; other site 218491018881 HMMPfam hit to PF02743, DE Cache domain, score 0.0008 218491018882 HMMPfam hit to PF00990, DE GGDEF domain, score 1.4e-58 218491018883 DNA polymerase II; Reviewed; Region: PRK05762 218491018884 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 218491018885 active site 218491018886 catalytic site [active] 218491018887 substrate binding site [chemical binding]; other site 218491018888 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 218491018889 active site 218491018890 metal-binding site 218491018891 HMMPfam hit to PF03104, DE DNA polymerase family B, exonuclease domain, score 8.4e-14 218491018892 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00136, DE DNA polymerase family B, score 2.6e-70 218491018893 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018894 PS00116 DNA polymerase family B signature. 218491018895 ATP-dependent helicase HepA; Validated; Region: PRK04914 218491018896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491018897 ATP binding site [chemical binding]; other site 218491018898 putative Mg++ binding site [ion binding]; other site 218491018899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491018900 nucleotide binding region [chemical binding]; other site 218491018901 ATP-binding site [chemical binding]; other site 218491018902 HMMPfam hit to PF00176, DE SNF2 family N-terminal domain, score 6.8e-59 218491018903 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 8.7e-16 218491018904 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218491018905 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218491018906 active site 218491018907 HMMPfam hit to PF00849, DE RNA pseudouridylate synthase, score 4.6e-56 218491018908 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 218491018909 Signal peptide predicted for ECA3855 by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.477 between residues 22 and 23; signal peptide 218491018910 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 218491018911 putative metal binding site [ion binding]; other site 218491018912 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218491018913 HSP70 interaction site [polypeptide binding]; other site 218491018914 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00226, DE DnaJ domain, score 1.2e-08 218491018915 Predicted helix-turn-helix motif with score 1030.000, SD 2.70 at aa 153-174, sequence RVLYVIADELGVTREQFEFFLR 218491018916 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 218491018917 Signal peptide predicted for ECA3856 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25; signal peptide 218491018918 OstA-like protein; Region: OstA; pfam03968 218491018919 Organic solvent tolerance protein; Region: OstA_C; pfam04453 218491018920 Signal peptide predicted for ECA3857 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 20 and 21; signal peptide 218491018921 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 218491018922 SurA N-terminal domain; Region: SurA_N; pfam09312 218491018923 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 218491018924 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 218491018925 HMMPfam hit to PF00639, DE PPIC-type PPIASE domain, score 9.2e-34 218491018926 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 218491018927 HMMPfam hit to PF00639, DE PPIC-type PPIASE domain, score 1.7e-43 218491018928 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 218491018929 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 218491018930 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 218491018931 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 218491018932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491018933 S-adenosylmethionine binding site [chemical binding]; other site 218491018934 HMMPfam hit to PF00398, DE Ribosomal RNA adenine dimethylase, score 3.8e-105 218491018935 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 218491018936 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 218491018937 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 218491018938 active site 218491018939 metal binding site [ion binding]; metal-binding site 218491018940 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 3e-15 218491018941 Protein of unknown function, DUF606; Region: DUF606; pfam04657 218491018942 5 probable transmembrane helices predicted for ECA3862 by TMHMM2.0 at aa 20-42, 55-77, 92-111, 116-138 and 148-170 218491018943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491018944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491018945 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 218491018946 putative substrate binding pocket [chemical binding]; other site 218491018947 putative dimerization interface [polypeptide binding]; other site 218491018948 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 7.9e-17 218491018949 PS00044 Bacterial regulatory proteins, lysR family signature. 218491018950 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.4e-25 218491018951 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 218491018952 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 218491018953 folate binding site [chemical binding]; other site 218491018954 NADP+ binding site [chemical binding]; other site 218491018955 HMMPfam hit to PF00186, DE Dihydrofolate reductase, score 2.1e-52 218491018956 PS00075 Dihydrofolate reductase signature. 218491018957 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491018958 hypothetical protein; Provisional; Region: PRK09917 218491018959 Signal peptide predicted for ECA3865 by SignalP 2.0 HMM (Signal peptide probabilty 0.742) with cleavage site probability 0.230 between residues 16 and 17; signal peptide 218491018960 4 probable transmembrane helices predicted for ECA3865 by TMHMM2.0 at aa 7-29, 57-79, 91-113 and 133-155 218491018961 Uncharacterized conserved protein [Function unknown]; Region: COG2966 218491018962 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 218491018963 3 probable transmembrane helices predicted for ECA3866 by TMHMM2.0 at aa 179-201, 211-233 and 246-268 218491018964 LysE type translocator; Region: LysE; cl00565 218491018965 5 probable transmembrane helices predicted for ECA3867 by TMHMM2.0 at aa 5-27, 40-62, 77-96, 117-139 and 149-171 218491018966 HMMPfam hit to PF01810, DE LysE type translocator, score 2.5e-19 218491018967 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 218491018968 putative dimer interface [polypeptide binding]; other site 218491018969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491018970 Predicted transcriptional regulator [Transcription]; Region: COG2378 218491018971 HTH domain; Region: HTH_11; pfam08279 218491018972 WYL domain; Region: WYL; pfam13280 218491018973 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 21-42, sequence VTGAYLAEKLGVSQRTLYRDIA 218491018974 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 218491018975 Signal peptide predicted for ECA3870 by SignalP 2.0 HMM (Signal peptide probabilty 0.767) with cleavage site probability 0.700 between residues 23 and 24; signal peptide 218491018976 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218491018977 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 218491018978 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 218491018979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218491018980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 218491018981 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 218491018982 IMP binding site; other site 218491018983 dimer interface [polypeptide binding]; other site 218491018984 interdomain contacts; other site 218491018985 partial ornithine binding site; other site 218491018986 HMMPfam hit to PF02142, DE MGS-like domain, score 6.8e-31 218491018987 HMMPfam hit to PF02786, DE Carbamoyl-phosphate synthase L chain, ATP binding domain, score 1.1e-26 218491018988 PS00017 ATP/GTP-binding site motif A (P-loop). 218491018989 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218491018990 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218491018991 HMMPfam hit to PF00289, DE Carbamoyl-phosphate synthase L chain, N-terminal domain, score 5.5e-26 218491018992 HMMPfam hit to PF02787, DE Carbamoyl-phosphate synthetase large chain, oligomerisation domain, score 4e-65 218491018993 HMMPfam hit to PF02786, DE Carbamoyl-phosphate synthase L chain, ATP binding domain, score 5.1e-132 218491018994 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218491018995 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218491018996 HMMPfam hit to PF00289, DE Carbamoyl-phosphate synthase L chain, N-terminal domain, score 1.1e-62 218491018997 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491018998 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 218491018999 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 218491019000 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 218491019001 catalytic site [active] 218491019002 subunit interface [polypeptide binding]; other site 218491019003 HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 2.1e-70 218491019004 PS00442 Glutamine amidotransferases class-I active site. 218491019005 HMMPfam hit to PF00988, DE Carbamoyl-phosphate synthase small chain, CPSase domain, score 7.4e-89 218491019006 dihydrodipicolinate reductase; Provisional; Region: PRK00048 218491019007 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 218491019008 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 218491019009 HMMPfam hit to PF01113, DE Dihydrodipicolinate reductase, N-terminus, score 1.9e-102 218491019010 PS01298 Dihydrodipicolinate reductase signature. 218491019011 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 218491019012 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 218491019013 HMMPfam hit to PF02401, DE LytB protein, score 4.4e-179 218491019014 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 218491019015 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218491019016 HMMPfam hit to PF00254, DE FKBP-type peptidyl-prolyl cis-trans isomerase, score 1.8e-07 218491019017 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 218491019018 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218491019019 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 218491019020 lipoprotein signal peptidase; Provisional; Region: PRK14787 218491019021 HMMPfam hit to PF01252, DE Signal peptidase (SPase) II, score 3.2e-79 218491019022 4 probable transmembrane helices predicted for ECA3875 by TMHMM2.0 at aa 13-35, 69-91, 98-120 and 135-157 218491019023 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 218491019024 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218491019025 active site 218491019026 HIGH motif; other site 218491019027 nucleotide binding site [chemical binding]; other site 218491019028 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218491019029 active site 218491019030 KMSKS motif; other site 218491019031 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 218491019032 tRNA binding surface [nucleotide binding]; other site 218491019033 anticodon binding site; other site 218491019034 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218491019035 HMMPfam hit to PF00133, DE tRNA synthetases class I (I, L, M and V), score 0 218491019036 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491019037 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 218491019038 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 218491019039 active site 218491019040 Riboflavin kinase; Region: Flavokinase; smart00904 218491019041 HMMPfam hit to PF01687, DE Riboflavin kinase / FAD synthetase, score 5.7e-62 218491019042 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 218491019043 HMMPfam hit to PF01649, DE Ribosomal protein S20, score 3.4e-41 218491019044 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 218491019045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491019046 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 218491019047 putative dimerization interface [polypeptide binding]; other site 218491019048 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 0.00057 218491019049 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.6e-21 218491019050 PS00044 Bacterial regulatory proteins, lysR family signature. 218491019051 Predicted helix-turn-helix motif with score 1067.000, SD 2.82 at aa 19-40, sequence GSVAGAAEMLFLTPQTITGQIK 218491019052 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 218491019053 11 probable transmembrane helices predicted for ECA3880 by TMHMM2.0 at aa 33-55, 84-103, 120-142, 152-171, 178-200, 205-222, 234-265, 285-307, 314-336, 356-378 and 390-412 218491019054 chaperone protein DnaJ; Provisional; Region: PRK10767 218491019055 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218491019056 HSP70 interaction site [polypeptide binding]; other site 218491019057 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 218491019058 substrate binding site [polypeptide binding]; other site 218491019059 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 218491019060 Zn binding sites [ion binding]; other site 218491019061 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 218491019062 dimer interface [polypeptide binding]; other site 218491019063 HMMPfam hit to PF01556, DE DnaJ C terminal region, score 7.8e-77 218491019064 HMMPfam hit to PF00684, DE DnaJ central domain (4 repeats), score 2.1e-45 218491019065 PS00190 Cytochrome c family heme-binding site signature. 218491019066 PS00637 CXXCXGXG dnaJ domain signature. 218491019067 PS00190 Cytochrome c family heme-binding site signature. 218491019068 HMMPfam hit to PF00226, DE DnaJ domain, score 5.4e-38 218491019069 PS00636 Nt-dnaJ domain signature. 218491019070 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 218491019071 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 218491019072 nucleotide binding site [chemical binding]; other site 218491019073 HMMPfam hit to PF00012, DE Hsp70 protein, score 0 218491019074 PS01036 Heat shock hsp70 proteins family signature 3. 218491019075 PS00329 Heat shock hsp70 proteins family signature 2. 218491019076 PS00297 Heat shock hsp70 proteins family signature 1. 218491019077 hypothetical protein; Provisional; Region: PRK10659 218491019078 HMMPfam hit to PF01184, DE GPR1/FUN34/yaaH family, score 8.2e-92 218491019079 6 probable transmembrane helices predicted for ECA3883 by TMHMM2.0 at aa 31-50, 60-82, 89-111, 126-145, 152-169 and 174-196 218491019080 metabolite-proton symporter; Region: 2A0106; TIGR00883 218491019081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491019082 putative substrate translocation pore; other site 218491019083 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 2.4e-22 218491019084 12 probable transmembrane helices predicted for ECA3884 by TMHMM2.0 at aa 20-42, 62-84, 97-119, 124-146, 155-177, 192-214, 246-268, 283-305, 312-329, 339-361, 373-395 and 399-421 218491019085 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 218491019086 MPT binding site; other site 218491019087 trimer interface [polypeptide binding]; other site 218491019088 HMMPfam hit to PF00994, DE Probable molybdopterin binding domain, score 2.7e-38 218491019089 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 218491019090 Signal peptide predicted for ECA3886 by SignalP 2.0 HMM (Signal peptide probabilty 0.832) with cleavage site probability 0.307 between residues 36 and 37; signal peptide 218491019091 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 218491019092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491019093 metal binding site [ion binding]; metal-binding site 218491019094 active site 218491019095 I-site; other site 218491019096 2 probable transmembrane helices predicted for ECA3886 by TMHMM2.0 at aa 12-34 and 170-192 218491019097 HMMPfam hit to PF00990, DE GGDEF domain, score 1.5e-44 218491019098 transaldolase-like protein; Provisional; Region: PTZ00411 218491019099 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 218491019100 active site 218491019101 dimer interface [polypeptide binding]; other site 218491019102 catalytic residue [active] 218491019103 HMMPfam hit to PF00923, DE Transaldolase, score 6.9e-173 218491019104 PS00958 Transaldolase active site. 218491019105 PS01054 Transaldolase signature 1. 218491019106 hypothetical protein; Validated; Region: PRK02101 218491019107 HMMPfam hit to PF03883, DE Protein of unknown function (DUF328), score 2e-173 218491019108 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491019109 threonine synthase; Validated; Region: PRK09225 218491019110 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 218491019111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218491019112 catalytic residue [active] 218491019113 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 1.4e-32 218491019114 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218491019115 homoserine kinase; Provisional; Region: PRK01212 218491019116 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 218491019117 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 218491019118 HMMPfam hit to PF00288, DE GHMP kinases ATP-binding protein, score 5.9e-65 218491019119 PS00627 GHMP kinases ATP-binding domain. 218491019120 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491019121 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 218491019122 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 218491019123 putative catalytic residues [active] 218491019124 putative nucleotide binding site [chemical binding]; other site 218491019125 putative aspartate binding site [chemical binding]; other site 218491019126 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 218491019127 dimer interface [polypeptide binding]; other site 218491019128 putative threonine allosteric regulatory site; other site 218491019129 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 218491019130 putative threonine allosteric regulatory site; other site 218491019131 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 218491019132 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 218491019133 HMMPfam hit to PF00742, DE Homoserine dehydrogenase, score 2.4e-96 218491019134 PS01042 Homoserine dehydrogenase signature. 218491019135 HMMPfam hit to PF03447, DE Homoserine dehydrogenase, NAD binding domain, score 1.2e-51 218491019136 HMMPfam hit to PF01842, DE ACT domain, score 4.1e-07 218491019137 HMMPfam hit to PF01842, DE ACT domain, score 2e-08 218491019138 HMMPfam hit to PF00696, DE Amino acid kinase family, score 3.5e-59 218491019139 PS00324 Aspartokinase signature. 218491019140 putative RNA methyltransferase; Provisional; Region: PRK10433 218491019141 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 218491019142 HMMPfam hit to PF00588, DE SpoU rRNA Methylase family, score 6.6e-39 218491019143 two-component response regulator; Provisional; Region: PRK11173 218491019144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491019145 active site 218491019146 phosphorylation site [posttranslational modification] 218491019147 intermolecular recognition site; other site 218491019148 dimerization interface [polypeptide binding]; other site 218491019149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491019150 DNA binding site [nucleotide binding] 218491019151 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 6.6e-33 218491019152 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 9.6e-28 218491019153 hypothetical protein; Provisional; Region: PRK10756 218491019154 Signal peptide predicted for ECA3894 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.964 between residues 22 and 23; signal peptide 218491019155 CreA protein; Region: CreA; pfam05981 218491019156 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 218491019157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491019158 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 218491019159 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 2.2e-09 218491019160 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 22-43, sequence LSLDNVAAKAGYSKWHLQRMFK 218491019161 PS00041 Bacterial regulatory proteins, araC family signature. 218491019162 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 2.6e-09 218491019163 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218491019164 catalytic core [active] 218491019165 HMMPfam hit to PF00300, DE Phosphoglycerate mutase family, score 1e-58 218491019166 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 218491019167 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 218491019168 HMMPfam hit to PF01931, DE Protein of unknown function DUF84, score 8.5e-68 218491019169 Trp operon repressor; Provisional; Region: PRK01381 218491019170 HMMPfam hit to PF01371, DE Trp repressor protein, score 5.3e-52 218491019171 lytic murein transglycosylase; Provisional; Region: PRK11619 218491019172 Signal peptide predicted for ECA3900 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.997 between residues 27 and 28; signal peptide 218491019173 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 218491019174 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218491019175 catalytic residue [active] 218491019176 HMMPfam hit to PF01464, DE Transglycosylase SLT domain, score 4.9e-39 218491019177 PS00922 Prokaryotic transglycosylases signature. 218491019178 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 218491019179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491019180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491019181 ABC transporter; Region: ABC_tran_2; pfam12848 218491019182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491019183 HMMPfam hit to PF00005, DE ABC transporter, score 8.2e-55 218491019184 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019185 PS00211 ABC transporters family signature. 218491019186 HMMPfam hit to PF00005, DE ABC transporter, score 6.4e-45 218491019187 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019188 Signal peptide predicted for ECA3902 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.446 between residues 52 and 53; signal peptide 218491019189 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 218491019190 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 218491019191 dimer interface [polypeptide binding]; other site 218491019192 ligand binding site [chemical binding]; other site 218491019193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491019194 dimerization interface [polypeptide binding]; other site 218491019195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491019196 dimer interface [polypeptide binding]; other site 218491019197 putative CheW interface [polypeptide binding]; other site 218491019198 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 2.3e-111 218491019199 PS00538 Bacterial chemotaxis sensory transducers signature. 218491019200 HMMPfam hit to PF00672, DE HAMP domain, score 6.1e-10 218491019201 2 probable transmembrane helices predicted for ECA3902 by TMHMM2.0 at aa 29-51 and 208-230 218491019202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491019203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491019204 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 218491019205 putative effector binding pocket; other site 218491019206 dimerization interface [polypeptide binding]; other site 218491019207 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.1e-50 218491019208 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.3e-18 218491019209 PS00044 Bacterial regulatory proteins, lysR family signature. 218491019210 Predicted helix-turn-helix motif with score 1299.000, SD 3.61 at aa 18-39, sequence GSFTQAARKAGLAKSSLSLRIS 218491019211 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 218491019212 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 218491019213 putative NAD(P) binding site [chemical binding]; other site 218491019214 dimer interface [polypeptide binding]; other site 218491019215 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 2.3e-41 218491019216 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 218491019217 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 218491019218 ligand binding site [chemical binding]; other site 218491019219 NAD binding site [chemical binding]; other site 218491019220 tetramer interface [polypeptide binding]; other site 218491019221 catalytic site [active] 218491019222 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 218491019223 L-serine binding site [chemical binding]; other site 218491019224 ACT domain interface; other site 218491019225 HMMPfam hit to PF01842, DE ACT domain, score 4.7e-09 218491019226 HMMPfam hit to PF02826, DE D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 1.2e-91 218491019227 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 218491019228 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 218491019229 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 218491019230 HMMPfam hit to PF00389, DE D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 1.8e-31 218491019231 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 218491019232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218491019233 active site 218491019234 dimer interface [polypeptide binding]; other site 218491019235 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 218491019236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491019237 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 218491019238 putative dimerization interface [polypeptide binding]; other site 218491019239 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.5e-22 218491019240 Predicted helix-turn-helix motif with score 1987.000, SD 5.95 at aa 19-40, sequence RGFERAAQKLCITQSAVSQRIK 218491019241 PS00044 Bacterial regulatory proteins, lysR family signature. 218491019242 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 4.8e-08 218491019243 Signal peptide predicted for ECA3908 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.952 between residues 28 and 29; signal peptide 218491019244 oxidative stress defense protein; Provisional; Region: PRK11087 218491019245 Uncharacterized conserved protein [Function unknown]; Region: COG2968 218491019246 arginine exporter protein; Provisional; Region: PRK09304 218491019247 Signal peptide predicted for ECA3909 by SignalP 2.0 HMM (Signal peptide probabilty 0.735) with cleavage site probability 0.701 between residues 26 and 27; signal peptide 218491019248 6 probable transmembrane helices predicted for ECA3909 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 109-127, 147-169 and 182-199 218491019249 HMMPfam hit to PF01810, DE LysE type translocator, score 2.2e-31 218491019250 mechanosensitive channel MscS; Provisional; Region: PRK10334 218491019251 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218491019252 HMMPfam hit to PF00924, DE Mechanosensitive ion channel, score 7.3e-76 218491019253 PS01246 Uncharacterized protein family UPF0003 signature. 218491019254 3 probable transmembrane helices predicted for ECA3910 by TMHMM2.0 at aa 21-43, 63-85 and 92-114 218491019255 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 218491019256 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 218491019257 active site 218491019258 intersubunit interface [polypeptide binding]; other site 218491019259 zinc binding site [ion binding]; other site 218491019260 Na+ binding site [ion binding]; other site 218491019261 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01116, DE Fructose-bisphosphate aldolase class-II, score 4.8e-211 218491019262 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 218491019263 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 218491019264 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 218491019265 Phosphoglycerate kinase; Region: PGK; pfam00162 218491019266 substrate binding site [chemical binding]; other site 218491019267 hinge regions; other site 218491019268 ADP binding site [chemical binding]; other site 218491019269 catalytic site [active] 218491019270 HMMPfam hit to PF00162, DE Phosphoglycerate kinase, score 9.8e-205 218491019271 PS00111 Phosphoglycerate kinase signature. 218491019272 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 218491019273 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 218491019274 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218491019275 HMMPfam hit to PF02800, DE Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 1.2e-70 218491019276 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 218491019277 HMMPfam hit to PF00044, DE Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 4.2e-71 218491019278 transketolase; Reviewed; Region: PRK12753 218491019279 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218491019280 TPP-binding site [chemical binding]; other site 218491019281 dimer interface [polypeptide binding]; other site 218491019282 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218491019283 PYR/PP interface [polypeptide binding]; other site 218491019284 dimer interface [polypeptide binding]; other site 218491019285 TPP binding site [chemical binding]; other site 218491019286 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218491019287 HMMPfam hit to PF02780, DE Transketolase, C-terminal domain, score 3.2e-13 218491019288 HMMPfam hit to PF02779, DE Transketolase, pyridine binding domain, score 8.2e-66 218491019289 PS00802 Transketolase signature 2. 218491019290 HMMPfam hit to PF00456, DE Transketolase, thiamine diphosphate binding domain, score 1.9e-240 218491019291 PS00801 Transketolase signature 1. 218491019292 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 218491019293 Signal peptide predicted for ECA3915 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.609 between residues 37 and 38; signal peptide 218491019294 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491019295 HMMPfam hit to PF01435, DE Peptidase family M48, score 5.2e-05 218491019296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 218491019297 DNA binding residues [nucleotide binding] 218491019298 dimerization interface [polypeptide binding]; other site 218491019299 HMMPfam hit to PF00196, DE Bacterial regulatory proteins, luxR family, score 0.0017 218491019300 PS00622 Bacterial regulatory proteins, luxR family signature. 218491019301 arginine decarboxylase; Provisional; Region: PRK05354 218491019302 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 218491019303 dimer interface [polypeptide binding]; other site 218491019304 active site 218491019305 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491019306 catalytic residues [active] 218491019307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 218491019308 HMMPfam hit to PF00278, DE Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score 9.5e-49 218491019309 HMMPfam hit to PF02784, DE Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 9.5e-111 218491019310 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 218491019311 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 218491019312 S-adenosylmethionine synthetase; Validated; Region: PRK05250 218491019313 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 218491019314 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 218491019315 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 218491019316 HMMPfam hit to PF00438, DE S-adenosylmethionine synthetase, N-terminal domain, score 6.7e-62 218491019317 HMMPfam hit to PF02772, DE S-adenosylmethionine synthetase, central domain, score 1.5e-81 218491019318 PS00376 S-adenosylmethionine synthetase signature 1. 218491019319 HMMPfam hit to PF02773, DE S-adenosylmethionine synthetase, C-terminal domain, score 2.7e-92 218491019320 PS00377 S-adenosylmethionine synthetase signature 2. 218491019321 hypothetical protein; Provisional; Region: PRK04860 218491019322 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 218491019323 HMMPfam hit to PF03926, DE metallopeptidase (SprT family), score 5.3e-72 218491019324 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491019325 DNA-specific endonuclease I; Provisional; Region: PRK15137 218491019326 Signal peptide predicted for ECA3922 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.906 between residues 22 and 23; signal peptide 218491019327 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 218491019328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 218491019329 RNA methyltransferase, RsmE family; Region: TIGR00046 218491019330 PS00215 Mitochondrial energy transfer proteins signature. 218491019331 glutathione synthetase; Provisional; Region: PRK05246 218491019332 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 218491019333 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 218491019334 HMMPfam hit to PF02951, DE Prokaryotic glutathione synthetase, N-terminal domain, score 1.6e-69 218491019335 PS00018 EF-hand calcium-binding domain. 218491019336 HMMPfam hit to PF02955, DE Prokaryotic glutathione synthetase, ATP-binding domain, score 4.8e-74 218491019337 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491019338 hypothetical protein; Validated; Region: PRK00228 218491019339 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02622, DE Uncharacterized ACR, COG1678, score 4.9e-94 218491019340 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 218491019341 HMMPfam hit to PF03652, DE Uncharacterised protein family (UPF0081), score 3.5e-68 218491019342 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 218491019343 AMP binding site [chemical binding]; other site 218491019344 metal binding site [ion binding]; metal-binding site 218491019345 active site 218491019346 HMMPfam hit to PF00316, DE Fructose-1-6-bisphosphatase, score 7.6e-206 218491019347 PS00124 Fructose-1-6-bisphosphatase active site. 218491019348 Signal peptide predicted for ECA3928 by SignalP 2.0 HMM (Signal peptide probabilty 0.918) with cleavage site probability 0.485 between residues 20 and 21; signal peptide 218491019349 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 218491019350 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218491019351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218491019352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218491019353 HMMPfam hit to PF01225, DE Mur ligase family, catalytic domain, score 6e-60 218491019354 HMMPfam hit to PF02875, DE Mur ligase family, glutamate ligase domain, score 8.7e-17 218491019355 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 218491019356 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 218491019357 GDP-binding site [chemical binding]; other site 218491019358 ACT binding site; other site 218491019359 IMP binding site; other site 218491019360 HMMPfam hit to PF00709, DE Adenylosuccinate synthetase, score 0 218491019361 PS00513 Adenylosuccinate synthetase active site. 218491019362 PS01266 Adenylosuccinate synthetase GTP-binding site. 218491019363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 218491019364 2 probable transmembrane helices predicted for ECA3930 by TMHMM2.0 at aa 5-27 and 40-62 218491019365 FtsH protease regulator HflC; Provisional; Region: PRK11029 218491019366 Signal peptide predicted for ECA3931 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.351 between residues 18 and 19; signal peptide 218491019367 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 218491019368 HMMPfam hit to PF01145, DE SPFH domain / Band 7 family, score 1.2e-54 218491019369 1 probable transmembrane helix predicted for ECA3931 by TMHMM2.0 at aa 5-24 218491019370 FtsH protease regulator HflK; Provisional; Region: PRK10930 218491019371 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 218491019372 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 218491019373 HMMPfam hit to PF01145, DE SPFH domain / Band 7 family, score 3.4e-49 218491019374 1 probable transmembrane helix predicted for ECA3932 by TMHMM2.0 at aa 77-99 218491019375 GTPase HflX; Provisional; Region: PRK11058 218491019376 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 218491019377 HflX GTPase family; Region: HflX; cd01878 218491019378 G1 box; other site 218491019379 GTP/Mg2+ binding site [chemical binding]; other site 218491019380 Switch I region; other site 218491019381 G2 box; other site 218491019382 G3 box; other site 218491019383 Switch II region; other site 218491019384 G4 box; other site 218491019385 G5 box; other site 218491019386 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019387 bacterial Hfq-like; Region: Hfq; cd01716 218491019388 hexamer interface [polypeptide binding]; other site 218491019389 Sm1 motif; other site 218491019390 RNA binding site [nucleotide binding]; other site 218491019391 Sm2 motif; other site 218491019392 HMMPfam hit to PF03329, DE Host factor Hfq, score 2.8e-42 218491019393 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 218491019394 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 218491019395 HMMPfam hit to PF01715, DE IPP transferase, score 1.7e-146 218491019396 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019397 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 218491019398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491019399 ATP binding site [chemical binding]; other site 218491019400 Mg2+ binding site [ion binding]; other site 218491019401 G-X-G motif; other site 218491019402 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 218491019403 ATP binding site [chemical binding]; other site 218491019404 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 218491019405 HMMPfam hit to PF01119, DE DNA mismatch repair protein, C-terminal domain, score 5.2e-36 218491019406 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.5e-06 218491019407 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 218491019408 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 218491019409 Signal peptide predicted for ECA3937 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 22 and 23; signal peptide 218491019410 AMIN domain; Region: AMIN; pfam11741 218491019411 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218491019412 active site 218491019413 metal binding site [ion binding]; metal-binding site 218491019414 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218491019415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218491019416 HMMPfam hit to PF01476, DE LysM domain, score 2.6e-16 218491019417 HMMPfam hit to PF01476, DE LysM domain, score 5.8e-13 218491019418 HMMPfam hit to PF01520, DE N-acetylmuramoyl-L-alanine amidase, score 6.7e-75 218491019419 ADP-binding protein; Provisional; Region: PRK10646 218491019420 HMMPfam hit to PF02367, DE Uncharacterised P-loop hydrolase UPF0079, score 2.3e-58 218491019421 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019422 putative carbohydrate kinase; Provisional; Region: PRK10565 218491019423 Uncharacterized conserved protein [Function unknown]; Region: COG0062 218491019424 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 218491019425 putative substrate binding site [chemical binding]; other site 218491019426 putative ATP binding site [chemical binding]; other site 218491019427 HMMPfam hit to PF01256, DE Carbohydrate kinase, score 5.6e-91 218491019428 PS01050 Uncharacterized protein family UPF0031 signature 2. 218491019429 PS01049 Uncharacterized protein family UPF0031 signature 1. 218491019430 HMMPfam hit to PF03853, DE YjeF-related protein N-terminus, score 3.7e-54 218491019431 epoxyqueuosine reductase; Region: TIGR00276 218491019432 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 218491019433 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.0071 218491019434 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491019435 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 218491019436 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 218491019437 catalytic residue [active] 218491019438 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 218491019439 catalytic residues [active] 218491019440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491019441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491019442 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 5.1e-68 218491019443 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 218491019444 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 218491019445 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 218491019446 dimer interface [polypeptide binding]; other site 218491019447 decamer (pentamer of dimers) interface [polypeptide binding]; other site 218491019448 catalytic triad [active] 218491019449 peroxidatic and resolving cysteines [active] 218491019450 HMMPfam hit to PF00578, DE AhpC/TSA family, score 2.2e-62 218491019451 11 probable transmembrane helices predicted for ECA3943 by TMHMM2.0 at aa 41-60, 65-82, 95-114, 124-143, 163-185, 200-222, 234-256, 266-288, 301-323, 338-360 and 367-389 218491019452 1 probable transmembrane helix predicted for ECA3944 by TMHMM2.0 at aa 7-29 218491019453 1 probable transmembrane helix predicted for ECA3945 by TMHMM2.0 at aa 13-32 218491019454 Signal peptide predicted for ECA3946 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25; signal peptide 218491019455 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 218491019456 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 218491019457 NAD binding site [chemical binding]; other site 218491019458 ligand binding site [chemical binding]; other site 218491019459 catalytic site [active] 218491019460 HMMPfam hit to PF02826, DE D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 1.3e-16 218491019461 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 218491019462 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 218491019463 putative NAD(P) binding site [chemical binding]; other site 218491019464 putative substrate binding site [chemical binding]; other site 218491019465 catalytic Zn binding site [ion binding]; other site 218491019466 structural Zn binding site [ion binding]; other site 218491019467 dimer interface [polypeptide binding]; other site 218491019468 HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 1.6e-103 218491019469 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 218491019470 PS00059 Zinc-containing alcohol dehydrogenases signature. 218491019471 PS00190 Cytochrome c family heme-binding site signature. 218491019472 Signal peptide predicted for ECA3951 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.969 between residues 23 and 24; signal peptide 218491019473 LysE type translocator; Region: LysE; cl00565 218491019474 6 probable transmembrane helices predicted for ECA3951 by TMHMM2.0 at aa 4-26, 38-60, 64-86, 114-136, 146-168 and 181-203 218491019475 HMMPfam hit to PF01810, DE LysE type translocator, score 1.2e-10 218491019476 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 218491019477 Signal peptide predicted for ECA3952 by SignalP 2.0 HMM (Signal peptide probabilty 0.727) with cleavage site probability 0.476 between residues 18 and 19; signal peptide 218491019478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491019479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491019480 dimerization interface [polypeptide binding]; other site 218491019481 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.5e-20 218491019482 Predicted helix-turn-helix motif with score 1645.000, SD 4.79 at aa 21-42, sequence GSFVKAAESLHVTHGAVSRQIR 218491019483 PS00044 Bacterial regulatory proteins, lysR family signature. 218491019484 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 2.8e-18 218491019485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491019486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491019487 putative substrate translocation pore; other site 218491019488 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00027 218491019489 12 probable transmembrane helices predicted for ECA3953 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-123, 135-157, 162-179, 199-218, 238-260, 265-287, 291-313, 325-347 and 357-376 218491019490 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491019491 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 218491019492 Walker A/P-loop; other site 218491019493 ATP binding site [chemical binding]; other site 218491019494 Q-loop/lid; other site 218491019495 ABC transporter signature motif; other site 218491019496 Walker B; other site 218491019497 D-loop; other site 218491019498 H-loop/switch region; other site 218491019499 HMMPfam hit to PF00005, DE ABC transporter, score 9.9e-60 218491019500 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019501 Signal peptide predicted for ECA3955 by SignalP 2.0 HMM (Signal peptide probabilty 0.926) with cleavage site probability 0.495 between residues 28 and 29; signal peptide 218491019502 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491019503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491019504 dimer interface [polypeptide binding]; other site 218491019505 conserved gate region; other site 218491019506 putative PBP binding loops; other site 218491019507 ABC-ATPase subunit interface; other site 218491019508 6 probable transmembrane helices predicted for ECA3955 by TMHMM2.0 at aa 9-26, 63-85, 98-120, 125-144, 179-201 and 221-243 218491019509 Signal peptide predicted for ECA3956 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 38 and 39; signal peptide 218491019510 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 218491019511 NMT1-like family; Region: NMT1_2; pfam13379 218491019512 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 218491019513 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 218491019514 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 1.6e-12 218491019515 Signal peptide predicted for ECA3958 by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.773 between residues 43 and 44; signal peptide 218491019516 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 218491019517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491019518 putative substrate translocation pore; other site 218491019519 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0031 218491019520 12 probable transmembrane helices predicted for ECA3958 by TMHMM2.0 at aa 13-35, 50-72, 81-98, 102-124, 136-158, 168-190, 211-233, 246-268, 275-292, 296-318, 339-356 and 366-388 218491019521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218491019522 putative DNA binding site [nucleotide binding]; other site 218491019523 dimerization interface [polypeptide binding]; other site 218491019524 putative Zn2+ binding site [ion binding]; other site 218491019525 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019526 HMMPfam hit to PF01022, DE Bacterial regulatory protein, arsR family, score 3e-05 218491019527 Predicted helix-turn-helix motif with score 1368.000, SD 3.85 at aa 43-64, sequence VCITLIADALHIAQPTASRHVD 218491019528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 218491019529 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 2.4e-06 218491019530 Cupin domain; Region: Cupin_2; pfam07883 218491019531 Signal peptide predicted for ECA3962 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 25 and 26; signal peptide 218491019532 2 probable transmembrane helices predicted for ECA3963 by TMHMM2.0 at aa 2-19 and 39-61 218491019533 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 218491019534 catalytic site [active] 218491019535 putative active site [active] 218491019536 putative substrate binding site [chemical binding]; other site 218491019537 dimer interface [polypeptide binding]; other site 218491019538 HMMPfam hit to PF00929, DE Exonuclease, score 6.6e-41 218491019539 GTPase RsgA; Reviewed; Region: PRK12288 218491019540 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218491019541 RNA binding site [nucleotide binding]; other site 218491019542 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 218491019543 GTPase/Zn-binding domain interface [polypeptide binding]; other site 218491019544 GTP/Mg2+ binding site [chemical binding]; other site 218491019545 G4 box; other site 218491019546 G5 box; other site 218491019547 G1 box; other site 218491019548 Switch I region; other site 218491019549 G2 box; other site 218491019550 G3 box; other site 218491019551 Switch II region; other site 218491019552 HMMPfam hit to PF03193, DE Protein of unknown function, DUF258, score 3.1e-80 218491019553 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019554 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 218491019555 HMMPfam hit to PF02666, DE Phosphatidylserine decarboxylase, score 1.3e-91 218491019556 putative mechanosensitive channel protein; Provisional; Region: PRK10929 218491019557 Signal peptide predicted for ECA3967 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 19 and 20; signal peptide 218491019558 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 218491019559 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218491019560 11 probable transmembrane helices predicted for ECA3967 by TMHMM2.0 at aa 478-495, 524-546, 566-588, 601-620, 630-652, 673-695, 699-721, 788-810, 830-852, 883-902 and 912-934 218491019561 HMMPfam hit to PF00924, DE Mechanosensitive ion channel, score 1.1e-71 218491019562 PS01246 Uncharacterized protein family UPF0003 signature. 218491019563 poxB regulator PoxA; Provisional; Region: PRK09350 218491019564 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218491019565 motif 1; other site 218491019566 dimer interface [polypeptide binding]; other site 218491019567 active site 218491019568 motif 2; other site 218491019569 motif 3; other site 218491019570 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00152, DE tRNA synthetases class II (D, K and N), score 3.3e-117 218491019571 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218491019572 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218491019573 Signal peptide predicted for ECA3969 by SignalP 2.0 HMM (Signal peptide probabilty 0.936) with cleavage site probability 0.506 between residues 25 and 26; signal peptide 218491019574 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 218491019575 L-aspartate oxidase; Provisional; Region: PRK06175 218491019576 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218491019577 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 218491019578 HMMPfam hit to PF00890, DE FAD binding domain, score 1.5e-205 218491019579 HMMPfam hit to PF02910, DE Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain, score 2.4e-66 218491019580 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 218491019581 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 218491019582 HMMPfam hit to PF00111, DE 2Fe-2S iron-sulfur cluster binding domain, score 8e-05 218491019583 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 218491019584 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.0067 218491019585 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491019586 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 218491019587 D-subunit interface [polypeptide binding]; other site 218491019588 Iron-sulfur protein interface; other site 218491019589 proximal quinone binding site [chemical binding]; other site 218491019590 HMMPfam hit to PF02300, DE Fumarate reductase subunit C, score 6e-79 218491019591 3 probable transmembrane helices predicted for ECA3971 by TMHMM2.0 at aa 32-51, 61-83 and 109-131 218491019592 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 218491019593 Iron-sulfur protein interface; other site 218491019594 proximal quinone binding site [chemical binding]; other site 218491019595 C-subunit interface; other site 218491019596 distal quinone binding site; other site 218491019597 HMMPfam hit to PF02313, DE Fumarate reductase subunit D, score 4.9e-80 218491019598 3 probable transmembrane helices predicted for ECA3972 by TMHMM2.0 at aa 20-42, 61-83 and 98-117 218491019599 Signal peptide predicted for ECA3973 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.453 between residues 41 and 42; signal peptide 218491019600 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 218491019601 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 218491019602 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491019603 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218491019604 PS00213 Lipocalin signature. 218491019605 Protein of unknown function, DUF486; Region: DUF486; cl01236 218491019606 4 probable transmembrane helices predicted for ECA3974 by TMHMM2.0 at aa 4-26, 33-55, 70-88 and 95-112 218491019607 Predicted small secreted protein [Function unknown]; Region: COG5510 218491019608 Signal peptide predicted for ECA3975 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.918 between residues 20 and 21; signal peptide 218491019609 1 probable transmembrane helix predicted for ECA3975 by TMHMM2.0 at aa 5-27 218491019610 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491019611 elongation factor P; Validated; Region: PRK00529 218491019612 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218491019613 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218491019614 RNA binding site [nucleotide binding]; other site 218491019615 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218491019616 RNA binding site [nucleotide binding]; other site 218491019617 HMMPfam hit to PF01132, DE Elongation factor P (EF-P), score 1.7e-105 218491019618 PS01275 Elongation factor P signature. 218491019619 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 218491019620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218491019621 FeS/SAM binding site; other site 218491019622 HMMPfam hit to PF02587, , score 1.8e-164 218491019623 Signal peptide predicted for ECA3978 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.470 between residues 30 and 31; signal peptide 218491019624 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 218491019625 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491019626 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 218491019627 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 218491019628 active site 218491019629 dimer interface [polypeptide binding]; other site 218491019630 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 218491019631 dimer interface [polypeptide binding]; other site 218491019632 active site 218491019633 HMMPfam hit to PF00342, DE Phosphoglucose isomerase, score 0 218491019634 PS00174 Phosphoglucose isomerase signature 2. 218491019635 PS00765 Phosphoglucose isomerase signature 1. 218491019636 aspartate kinase III; Validated; Region: PRK09084 218491019637 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 218491019638 nucleotide binding site [chemical binding]; other site 218491019639 substrate binding site [chemical binding]; other site 218491019640 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 218491019641 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 218491019642 dimer interface [polypeptide binding]; other site 218491019643 HMMPfam hit to PF00696, DE Amino acid kinase family, score 4.9e-53 218491019644 PS00324 Aspartokinase signature. 218491019645 HMMPfam hit to PF01842, DE ACT domain, score 0.00043 218491019646 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 218491019647 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 218491019648 PhoU domain; Region: PhoU; pfam01895 218491019649 HMMPfam hit to PF02690, DE Na+/Pi-cotransporter, score 2.6e-128 218491019650 9 probable transmembrane helices predicted for ECA3983 by TMHMM2.0 at aa 7-26, 46-68, 75-97, 102-121, 133-155, 175-197, 202-224, 239-261 and 274-296 218491019651 Signal peptide predicted for ECA3984 by SignalP 2.0 HMM (Signal peptide probabilty 0.887) with cleavage site probability 0.739 between residues 26 and 27; signal peptide 218491019652 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218491019653 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218491019654 transmembrane helices; other site 218491019655 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00939, DE Sodium:sulfate symporter transmembrane region, score 1.2e-163 218491019656 12 probable transmembrane helices predicted for ECA3984 by TMHMM2.0 at aa 7-25, 35-52, 54-76, 91-110, 190-212, 227-249, 272-294, 299-321, 334-356, 371-393, 400-422 and 456-478 218491019657 Signal peptide predicted for ECA3985 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 24 and 25; signal peptide 218491019658 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 218491019659 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491019660 N-terminal plug; other site 218491019661 ligand-binding site [chemical binding]; other site 218491019662 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 1.6e-29 218491019663 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218491019664 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.11 218491019665 PS00041 Bacterial regulatory proteins, araC family signature. 218491019666 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 3.5e-06 218491019667 Predicted helix-turn-helix motif with score 1288.000, SD 3.57 at aa 234-255, sequence YTLNELAQLAAMSTSSLRTKFR 218491019668 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 218491019669 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 218491019670 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 218491019671 substrate binding pocket [chemical binding]; other site 218491019672 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 218491019673 B12 binding site [chemical binding]; other site 218491019674 cobalt ligand [ion binding]; other site 218491019675 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 218491019676 HMMPfam hit to PF02965, DE Vitamin B12 dependent methionine synthase, activation domain, score 1.3e-172 218491019677 PS00678 Trp-Asp (WD) repeats signature. 218491019678 HMMPfam hit to PF02310, DE B12 binding domain, score 3.9e-50 218491019679 HMMPfam hit to PF02607, DE B12 binding domain, score 1.4e-45 218491019680 HMMPfam hit to PF00809, DE Pterin binding enzyme, score 3e-92 218491019681 HMMPfam hit to PF02574, DE Homocysteine S-methyltransferase, score 2.9e-153 218491019682 transcriptional repressor IclR; Provisional; Region: PRK11569 218491019683 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 218491019684 Bacterial transcriptional regulator; Region: IclR; pfam01614 218491019685 Predicted helix-turn-helix motif with score 1141.000, SD 3.07 at aa 47-68, sequence VALTDLAQQAGLPNSTTHRLLT 218491019686 HMMPfam hit to PF01614, DE Bacterial transcriptional regulator, score 4.8e-74 218491019687 PS01051 Bacterial regulatory proteins, iclR family signature. 218491019688 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 218491019689 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 218491019690 isocitrate lyase; Provisional; Region: PRK15063 218491019691 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 218491019692 tetramer interface [polypeptide binding]; other site 218491019693 active site 218491019694 Mg2+/Mn2+ binding site [ion binding]; other site 218491019695 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00463, DE Isocitrate lyase family, score 2.5e-266 218491019696 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218491019697 PS00161 Isocitrate lyase signature. 218491019698 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 218491019699 malate synthase A; Region: malate_syn_A; TIGR01344 218491019700 active site 218491019701 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01274, DE Malate synthase, score 0 218491019702 Predicted helix-turn-helix motif with score 1150.000, SD 3.10 at aa 441-462, sequence YGLMEDAATAEISRTSIWQWIR 218491019703 PS00510 Malate synthase signature. 218491019704 homoserine O-succinyltransferase; Provisional; Region: PRK05368 218491019705 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 218491019706 proposed active site lysine [active] 218491019707 conserved cys residue [active] 218491019708 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 218491019709 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 218491019710 trimer interface [polypeptide binding]; other site 218491019711 putative metal binding site [ion binding]; other site 218491019712 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 52 218491019713 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 4.5e+02 218491019714 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1.5e+02 218491019715 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 34 218491019716 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1.2e+02 218491019717 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 218491019718 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 218491019719 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 218491019720 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 218491019721 shikimate binding site; other site 218491019722 NAD(P) binding site [chemical binding]; other site 218491019723 HMMPfam hit to PF01488, DE Shikimate / quinate 5-dehydrogenase, score 9.8e-91 218491019724 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218491019725 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 218491019726 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218491019727 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218491019728 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 218491019729 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01300, DE yrdC domain, score 2.8e-69 218491019730 PS01147 SUA5/yciO/yrdC family signature. 218491019731 HMMPfam hit to PF01396, DE Topoisomerase DNA binding C4 zinc finger, score 5.6e-13 218491019732 HMMPfam hit to PF01396, DE Topoisomerase DNA binding C4 zinc finger, score 3.8e-14 218491019733 HMMPfam hit to PF01396, DE Topoisomerase DNA binding C4 zinc finger, score 7.4e-17 218491019734 hypothetical protein; Validated; Region: PRK03430 218491019735 hypothetical protein; Provisional; Region: PRK10736 218491019736 DNA protecting protein DprA; Region: dprA; TIGR00732 218491019737 HMMPfam hit to PF02481, DE SMF family, score 8.6e-101 218491019738 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 218491019739 active site 218491019740 catalytic residues [active] 218491019741 metal binding site [ion binding]; metal-binding site 218491019742 HMMPfam hit to PF01327, DE Polypeptide deformylase, score 8.5e-82 218491019743 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 218491019744 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 218491019745 putative active site [active] 218491019746 substrate binding site [chemical binding]; other site 218491019747 putative cosubstrate binding site; other site 218491019748 catalytic site [active] 218491019749 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 218491019750 substrate binding site [chemical binding]; other site 218491019751 HMMPfam hit to PF00551, DE Formyl transferase, score 1.2e-75 218491019752 PS00373 Phosphoribosylglycinamide formyltransferase active site. 218491019753 HMMPfam hit to PF02911, DE Formyl transferase, C-terminal domain, score 2.8e-42 218491019754 16S rRNA methyltransferase B; Provisional; Region: PRK10901 218491019755 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 218491019756 putative RNA binding site [nucleotide binding]; other site 218491019757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491019758 S-adenosylmethionine binding site [chemical binding]; other site 218491019759 HMMPfam hit to PF01029, DE NusB family, score 1.2e-37 218491019760 HMMPfam hit to PF01189, DE NOL1/NOP2/sun family, score 2.1e-120 218491019761 PS01153 NOL1/NOP2/sun family signature. 218491019762 PS00141 Eukaryotic and viral aspartyl proteases active site. 218491019763 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 218491019764 TrkA-N domain; Region: TrkA_N; pfam02254 218491019765 TrkA-C domain; Region: TrkA_C; pfam02080 218491019766 TrkA-N domain; Region: TrkA_N; pfam02254 218491019767 TrkA-C domain; Region: TrkA_C; pfam02080 218491019768 HMMPfam hit to PF02254, DE TrkA-N domain, score 6.8e-18 218491019769 HMMPfam hit to PF02080, DE TrkA-C domain, score 9.6e-17 218491019770 HMMPfam hit to PF02254, DE TrkA-N domain, score 6.9e-15 218491019771 HMMPfam hit to PF02080, DE TrkA-C domain, score 3.2e-13 218491019772 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 218491019773 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 218491019774 HMMPfam hit to PF01741, DE Large-conductance mechanosensitive channel, MscL, score 7.7e-81 218491019775 PS01327 Large-conductance mechanosensitive channels mscL family signature. 218491019776 2 probable transmembrane helices predicted for ECA4003 by TMHMM2.0 at aa 20-42 and 77-96 218491019777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 218491019778 HMMPfam hit to PF03889, DE Domain of unknown function, score 4.3e-22 218491019779 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 218491019780 HMMPfam hit to PF01196, DE Ribosomal protein L17, score 2.7e-66 218491019781 PS01167 Ribosomal protein L17 signature. 218491019782 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 218491019783 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 218491019784 alphaNTD homodimer interface [polypeptide binding]; other site 218491019785 alphaNTD - beta interaction site [polypeptide binding]; other site 218491019786 alphaNTD - beta' interaction site [polypeptide binding]; other site 218491019787 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 218491019788 HMMPfam hit to PF03118, DE Bacterial RNA polymerase, alpha chain C terminal domain, score 1.4e-34 218491019789 HMMPfam hit to PF01000, DE RNA polymerase Rpb3/RpoA insert domain, score 7.7e-104 218491019790 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 218491019791 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 218491019792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491019793 RNA binding surface [nucleotide binding]; other site 218491019794 HMMPfam hit to PF01479, DE S4 domain, score 1.3e-19 218491019795 PS00632 Ribosomal protein S4 signature. 218491019796 HMMPfam hit to PF00163, DE Ribosomal protein S4/S9 N-terminal domain, score 7.2e-38 218491019797 30S ribosomal protein S11; Validated; Region: PRK05309 218491019798 HMMPfam hit to PF00411, DE Ribosomal protein S11, score 2.2e-75 218491019799 PS00054 Ribosomal protein S11 signature. 218491019800 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 218491019801 30S ribosomal protein S13; Region: bact_S13; TIGR03631 218491019802 HMMPfam hit to PF00416, DE Ribosomal protein S13/S18, score 9.6e-58 218491019803 PS00646 Ribosomal protein S13 signature. 218491019804 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 218491019805 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00444, DE Ribosomal protein L36, score 6.7e-15 218491019806 PS00828 Ribosomal protein L36 signature. 218491019807 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 218491019808 SecY translocase; Region: SecY; pfam00344 218491019809 10 probable transmembrane helices predicted for ECA4011 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 369-391 and 401-423 218491019810 HMMPfam hit to PF00344, DE eubacterial secY protein, score 2.4e-202 218491019811 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 218491019812 PS00756 Protein secY signature 2. 218491019813 PS00755 Protein secY signature 1. 218491019814 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 218491019815 HMMPfam hit to PF00256, DE Ribosomal protein L15, score 9.3e-10 218491019816 PS00475 Ribosomal protein L15 signature. 218491019817 HMMPfam hit to PF01305, DE Ribosomal protein L15 amino terminal region, score 3.7e-58 218491019818 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 218491019819 23S rRNA binding site [nucleotide binding]; other site 218491019820 HMMPfam hit to PF00327, DE Ribosomal protein L30p/L7e, score 6e-24 218491019821 PS00634 Ribosomal protein L30 signature. 218491019822 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 218491019823 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 218491019824 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 218491019825 HMMPfam hit to PF03719, DE Ribosomal protein S5, C-terminal domain, score 8.5e-41 218491019826 HMMPfam hit to PF00333, DE Ribosomal protein S5, N-terminal domain, score 8.7e-40 218491019827 PS00585 Ribosomal protein S5 signature. 218491019828 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 218491019829 5S rRNA interface [nucleotide binding]; other site 218491019830 23S rRNA interface [nucleotide binding]; other site 218491019831 L5 interface [polypeptide binding]; other site 218491019832 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00861, DE Ribosomal L18p/L5e family, score 4.7e-52 218491019833 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 218491019834 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218491019835 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218491019836 HMMPfam hit to PF00347, DE Ribosomal protein L6, score 6.8e-29 218491019837 PS00525 Ribosomal protein L6 signature 1. 218491019838 HMMPfam hit to PF00347, DE Ribosomal protein L6, score 9.1e-21 218491019839 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 218491019840 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00410, DE Ribosomal protein S8, score 3.9e-72 218491019841 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218491019842 PS00053 Ribosomal protein S8 signature. 218491019843 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 218491019844 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00253, DE Ribosomal protein S14p/S29e, score 3.4e-51 218491019845 PS00527 Ribosomal protein S14 signature. 218491019846 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 218491019847 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 218491019848 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 218491019849 HMMPfam hit to PF00673, DE ribosomal L5P family C-terminus, score 5e-59 218491019850 HMMPfam hit to PF00281, DE Ribosomal protein L5, score 1.1e-32 218491019851 PS00358 Ribosomal protein L5 signature. 218491019852 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 218491019853 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 218491019854 RNA binding site [nucleotide binding]; other site 218491019855 HMMPfam hit to PF00467, DE KOW motif, score 4.5e-06 218491019856 PS01108 Ribosomal protein L24 signature. 218491019857 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 218491019858 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00238, DE Ribosomal protein L14p/L23e, score 3.6e-71 218491019859 PS00049 Ribosomal protein L14 signature. 218491019860 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 218491019861 HMMPfam hit to PF00366, DE Ribosomal protein S17, score 6.9e-41 218491019862 PS00056 Ribosomal protein S17 signature. 218491019863 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 218491019864 23S rRNA interface [nucleotide binding]; other site 218491019865 putative translocon interaction site; other site 218491019866 signal recognition particle (SRP54) interaction site; other site 218491019867 L23 interface [polypeptide binding]; other site 218491019868 trigger factor interaction site; other site 218491019869 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00831, DE Ribosomal L29 protein, score 6.7e-23 218491019870 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 218491019871 23S rRNA interface [nucleotide binding]; other site 218491019872 5S rRNA interface [nucleotide binding]; other site 218491019873 putative antibiotic binding site [chemical binding]; other site 218491019874 L25 interface [polypeptide binding]; other site 218491019875 L27 interface [polypeptide binding]; other site 218491019876 HMMPfam hit to PF00252, DE Ribosomal protein L16, score 7.4e-92 218491019877 PS00701 Ribosomal protein L16 signature 2. 218491019878 PS00586 Ribosomal protein L16 signature 1. 218491019879 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 218491019880 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 218491019881 G-X-X-G motif; other site 218491019882 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 218491019883 HMMPfam hit to PF00189, DE Ribosomal protein S3, C-terminal domain, score 1.5e-53 218491019884 PS00548 Ribosomal protein S3 signature. 218491019885 HMMPfam hit to PF00013, DE KH domain, score 9.1e-07 218491019886 HMMPfam hit to PF00417, DE Ribosomal protein S3, N-terminal domain, score 4.1e-28 218491019887 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 218491019888 protein-rRNA interface [nucleotide binding]; other site 218491019889 putative translocon binding site; other site 218491019890 HMMPfam hit to PF00237, DE Ribosomal protein L22p/L17e, score 3.8e-55 218491019891 PS00464 Ribosomal protein L22 signature. 218491019892 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 218491019893 HMMPfam hit to PF00203, DE Ribosomal protein S19, score 1.1e-52 218491019894 PS00323 Ribosomal protein S19 signature. 218491019895 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 218491019896 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 218491019897 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 218491019898 HMMPfam hit to PF03947, DE Ribosomal Proteins L2, C-terminal domain, score 3.8e-83 218491019899 PS00467 Ribosomal protein L2 signature. 218491019900 HMMPfam hit to PF00181, DE Ribosomal Proteins L2, RNA binding domain, score 2e-46 218491019901 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 218491019902 HMMPfam hit to PF00276, DE Ribosomal protein L23, score 1.3e-43 218491019903 PS00050 Ribosomal protein L23 signature. 218491019904 PS00430 TonB-dependent receptor proteins signature 1. 218491019905 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 218491019906 HMMPfam hit to PF00573, DE Ribosomal protein L4/L1 family, score 5.1e-55 218491019907 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 218491019908 HMMPfam hit to PF00297, DE Ribosomal protein L3, score 1.5e-100 218491019909 PS00474 Ribosomal protein L3 signature. 218491019910 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 218491019911 HMMPfam hit to PF00338, DE Ribosomal protein S10p/S20e, score 2.9e-59 218491019912 PS00361 Ribosomal protein S10 signature. 218491019913 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 218491019914 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 218491019915 heme binding site [chemical binding]; other site 218491019916 ferroxidase pore; other site 218491019917 ferroxidase diiron center [ion binding]; other site 218491019918 HMMPfam hit to PF00210, DE Ferritin-like domain, score 1.9e-49 218491019919 PS00549 Bacterioferritin signature. 218491019920 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 218491019921 elongation factor Tu; Reviewed; Region: PRK00049 218491019922 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 218491019923 G1 box; other site 218491019924 GEF interaction site [polypeptide binding]; other site 218491019925 GTP/Mg2+ binding site [chemical binding]; other site 218491019926 Switch I region; other site 218491019927 G2 box; other site 218491019928 G3 box; other site 218491019929 Switch II region; other site 218491019930 G4 box; other site 218491019931 G5 box; other site 218491019932 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218491019933 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 218491019934 Antibiotic Binding Site [chemical binding]; other site 218491019935 HMMPfam hit to PF03143, DE Elongation factor Tu C-terminal domain, score 6.5e-60 218491019936 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 3.5e-28 218491019937 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 6.5e-95 218491019938 PS00301 GTP-binding elongation factors signature. 218491019939 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019940 elongation factor G; Reviewed; Region: PRK00007 218491019941 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 218491019942 G1 box; other site 218491019943 putative GEF interaction site [polypeptide binding]; other site 218491019944 GTP/Mg2+ binding site [chemical binding]; other site 218491019945 Switch I region; other site 218491019946 G2 box; other site 218491019947 G3 box; other site 218491019948 Switch II region; other site 218491019949 G4 box; other site 218491019950 G5 box; other site 218491019951 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 218491019952 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 218491019953 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 218491019954 HMMPfam hit to PF00679, DE Elongation factor G C-terminus, score 4.9e-45 218491019955 HMMPfam hit to PF03764, DE Elongation factor G, domain IV, score 3.5e-69 218491019956 HMMPfam hit to PF03144, DE Elongation factor Tu domain 2, score 5.5e-24 218491019957 HMMPfam hit to PF00009, DE Elongation factor Tu GTP binding domain, score 3.7e-110 218491019958 PS00301 GTP-binding elongation factors signature. 218491019959 PS00017 ATP/GTP-binding site motif A (P-loop). 218491019960 30S ribosomal protein S7; Validated; Region: PRK05302 218491019961 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00177, DE Ribosomal protein S7p/S5e, score 4.3e-93 218491019962 PS00052 Ribosomal protein S7 signature. 218491019963 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 218491019964 S17 interaction site [polypeptide binding]; other site 218491019965 S8 interaction site; other site 218491019966 16S rRNA interaction site [nucleotide binding]; other site 218491019967 streptomycin interaction site [chemical binding]; other site 218491019968 23S rRNA interaction site [nucleotide binding]; other site 218491019969 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 218491019970 HMMPfam hit to PF00164, DE Ribosomal protein S12, score 4.5e-79 218491019971 PS00055 Ribosomal protein S12 signature. 218491019972 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 218491019973 sulfur relay protein TusC; Validated; Region: PRK00211 218491019974 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02635, DE DsrE/DsrF-like family, score 6.9e-33 218491019975 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 218491019976 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02635, DE DsrE/DsrF-like family, score 5.2e-47 218491019977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 218491019978 YheO-like PAS domain; Region: PAS_6; pfam08348 218491019979 HTH domain; Region: HTH_22; pfam13309 218491019980 Predicted helix-turn-helix motif with score 1342.000, SD 3.76 at aa 213-234, sequence DAINQVAERLNISKHTVYLYIR 218491019981 Signal peptide predicted for ECA4043 by SignalP 2.0 HMM (Signal peptide probabilty 0.612) with cleavage site probability 0.445 between residues 28 and 29; signal peptide 218491019982 putative metal dependent hydrolase; Provisional; Region: PRK11598 218491019983 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 218491019984 Sulfatase; Region: Sulfatase; pfam00884 218491019985 HMMPfam hit to PF02418, , score 2.3e-228 218491019986 5 probable transmembrane helices predicted for ECA4043 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 120-142 and 155-177 218491019987 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 218491019988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491019989 active site 218491019990 phosphorylation site [posttranslational modification] 218491019991 intermolecular recognition site; other site 218491019992 dimerization interface [polypeptide binding]; other site 218491019993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491019994 DNA binding site [nucleotide binding] 218491019995 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 1.3e-35 218491019996 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 2.4e-22 218491019997 sensor protein BasS/PmrB; Provisional; Region: PRK10755 218491019998 HAMP domain; Region: HAMP; pfam00672 218491019999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491020000 dimer interface [polypeptide binding]; other site 218491020001 phosphorylation site [posttranslational modification] 218491020002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491020003 ATP binding site [chemical binding]; other site 218491020004 Mg2+ binding site [ion binding]; other site 218491020005 G-X-G motif; other site 218491020006 2 probable transmembrane helices predicted for ECA4045 by TMHMM2.0 at aa 13-35 and 67-89 218491020007 HMMPfam hit to PF00672, DE HAMP domain, score 0.00011 218491020008 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 8.3e-11 218491020009 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 6.4e-24 218491020010 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 218491020011 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 218491020012 dimer interface [polypeptide binding]; other site 218491020013 active site 218491020014 glycine-pyridoxal phosphate binding site [chemical binding]; other site 218491020015 folate binding site [chemical binding]; other site 218491020016 HMMPfam hit to PF00464, DE Serine hydroxymethyltransferase, score 7.5e-247 218491020017 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 218491020018 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 218491020019 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491020020 catalytic residue [active] 218491020021 HMMPfam hit to PF01168, DE Alanine racemase, N-terminal domain, score 1.9e-61 218491020022 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 218491020023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491020024 DNA-binding site [nucleotide binding]; DNA binding site 218491020025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491020026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491020027 homodimer interface [polypeptide binding]; other site 218491020028 catalytic residue [active] 218491020029 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 6.8e-17 218491020030 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020031 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 218491020032 Signal peptide predicted for ECA4049 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 25 and 26; signal peptide 218491020033 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 218491020034 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218491020035 HMMPfam hit to PF00254, DE FKBP-type peptidyl-prolyl cis-trans isomerase, score 5.5e-41 218491020036 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 218491020037 HMMPfam hit to PF01346, DE Domain amino terminal to FKBP-type peptidyl-prolyl isomerase, score 2e-46 218491020038 phi X174 lysis protein; Provisional; Region: PRK02793 218491020039 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491020040 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491020041 HMMPfam hit to PF01638, DE Transcriptional regulator, score 7.8e-45 218491020042 SnoaL-like domain; Region: SnoaL_2; pfam12680 218491020043 short chain dehydrogenase; Provisional; Region: PRK06523 218491020044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491020045 NAD(P) binding site [chemical binding]; other site 218491020046 active site 218491020047 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 8.9e-38 218491020048 PS00061 Short-chain dehydrogenases/reductases family signature. 218491020049 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 218491020050 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218491020051 HMMPfam hit to PF00254, DE FKBP-type peptidyl-prolyl cis-trans isomerase, score 3.1e-10 218491020052 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218491020053 Signal peptide predicted for ECA4055 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.965 between residues 20 and 21; signal peptide 218491020054 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 218491020055 Signal peptide predicted for ECA4056 by SignalP 2.0 HMM (Signal peptide probabilty 0.610) with cleavage site probability 0.512 between residues 20 and 21; signal peptide 218491020056 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 218491020057 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 218491020058 TrkA-N domain; Region: TrkA_N; pfam02254 218491020059 HMMPfam hit to PF02254, DE TrkA-N domain, score 1.1e-12 218491020060 HMMPfam hit to PF00999, DE Sodium/hydrogen exchanger family, score 1.3e-19 218491020061 12 probable transmembrane helices predicted for ECA4056 by TMHMM2.0 at aa 15-37, 42-64, 69-87, 100-122, 127-149, 162-184, 194-216, 237-259, 279-301, 308-327, 342-364 and 371-390 218491020062 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 218491020063 HMMPfam hit to PF02525, DE Flavodoxin-like fold, score 6.5e-62 218491020064 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 218491020065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491020066 Walker A/P-loop; other site 218491020067 ATP binding site [chemical binding]; other site 218491020068 Q-loop/lid; other site 218491020069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491020070 ABC transporter signature motif; other site 218491020071 Walker B; other site 218491020072 D-loop; other site 218491020073 ABC transporter; Region: ABC_tran_2; pfam12848 218491020074 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218491020075 HMMPfam hit to PF00005, DE ABC transporter, score 3.7e-42 218491020076 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020077 PS00211 ABC transporters family signature. 218491020078 HMMPfam hit to PF00005, DE ABC transporter, score 1.1e-37 218491020079 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020080 PS00211 ABC transporters family signature. 218491020081 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 218491020082 6 probable transmembrane helices predicted for ECA4059 by TMHMM2.0 at aa 5-27, 40-62, 66-88, 113-135, 145-167 and 180-199 218491020083 putative hydrolase; Provisional; Region: PRK10985 218491020084 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 1.5e-14 218491020085 PS01133 Uncharacterized protein family UPF0017 signature. 218491020086 hypothetical protein; Provisional; Region: PRK04966 218491020087 phosphoribulokinase; Provisional; Region: PRK15453 218491020088 active site 218491020089 HMMPfam hit to PF00485, DE Phosphoribulokinase / Uridine kinase family, score 5.1e-132 218491020090 PS00567 Phosphoribulokinase signature. 218491020091 hypothetical protein; Provisional; Region: PRK10738 218491020092 HMMPfam hit to PF02566, DE OsmC-like protein, score 1.1e-44 218491020093 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 218491020094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218491020095 ligand binding site [chemical binding]; other site 218491020096 flexible hinge region; other site 218491020097 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 218491020098 putative switch regulator; other site 218491020099 non-specific DNA interactions [nucleotide binding]; other site 218491020100 DNA binding site [nucleotide binding] 218491020101 sequence specific DNA binding site [nucleotide binding]; other site 218491020102 putative cAMP binding site [chemical binding]; other site 218491020103 HMMPfam hit to PF00027, DE Cyclic nucleotide-binding domain, score 1.9e-31 218491020104 PS00888 Cyclic nucleotide-binding domain signature 1. 218491020105 PS00889 Cyclic nucleotide-binding domain signature 2. 218491020106 HMMPfam hit to PF00325, DE Bacterial regulatory proteins, crp family, score 2.1e-14 218491020107 PS00042 Bacterial regulatory proteins, crp family signature. 218491020108 Predicted helix-turn-helix motif with score 2127.000, SD 6.43 at aa 168-189, sequence ITRQEIGQIVGCSRETVGRILK 218491020109 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 218491020110 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491020111 inhibitor-cofactor binding pocket; inhibition site 218491020112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491020113 catalytic residue [active] 218491020114 HMMPfam hit to PF00202, DE Aminotransferase class-III, score 3.2e-186 218491020115 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491020116 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 218491020117 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 218491020118 glutamine binding [chemical binding]; other site 218491020119 catalytic triad [active] 218491020120 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00117, DE Glutamine amidotransferase class-I, score 1.1e-85 218491020121 PS00442 Glutamine amidotransferases class-I active site. 218491020122 Signal peptide predicted for ECA4067 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23; signal peptide 218491020123 Pectate lyase; Region: Pec_lyase_C; pfam00544 218491020124 HMMPfam hit to PF00544, DE Pectate lyase, score 1.9e-170 218491020125 Signal peptide predicted for ECA4068 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 22 and 23; signal peptide 218491020126 Pectate lyase; Region: Pec_lyase_C; pfam00544 218491020127 HMMPfam hit to PF00544, DE Pectate lyase, score 4.7e-166 218491020128 Signal peptide predicted for ECA4069 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23; signal peptide 218491020129 Pectate lyase; Region: Pec_lyase_C; pfam00544 218491020130 HMMPfam hit to PF00544, DE Pectate lyase, score 1.1e-171 218491020131 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 218491020132 Signal peptide predicted for ECA4070 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.919 between residues 26 and 27; signal peptide 218491020133 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 218491020134 Signal peptide predicted for ECA4071 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 23 and 24; signal peptide 218491020135 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 218491020136 substrate binding site [chemical binding]; other site 218491020137 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00160, DE Cyclophilin type peptidyl-prolyl cis-trans isomerase, score 7.6e-73 218491020138 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 218491020139 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 218491020140 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491020141 Walker A/P-loop; other site 218491020142 ATP binding site [chemical binding]; other site 218491020143 Q-loop/lid; other site 218491020144 ABC transporter signature motif; other site 218491020145 Walker B; other site 218491020146 D-loop; other site 218491020147 H-loop/switch region; other site 218491020148 HMMPfam hit to PF00005, DE ABC transporter, score 4.8e-63 218491020149 PS00211 ABC transporters family signature. 218491020150 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 218491020152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491020153 Walker A/P-loop; other site 218491020154 ATP binding site [chemical binding]; other site 218491020155 Q-loop/lid; other site 218491020156 ABC transporter signature motif; other site 218491020157 Walker B; other site 218491020158 D-loop; other site 218491020159 H-loop/switch region; other site 218491020160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491020161 HMMPfam hit to PF00005, DE ABC transporter, score 8.6e-42 218491020162 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020163 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218491020164 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218491020165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491020166 dimer interface [polypeptide binding]; other site 218491020167 conserved gate region; other site 218491020168 ABC-ATPase subunit interface; other site 218491020169 5 probable transmembrane helices predicted for ECA4074 by TMHMM2.0 at aa 45-67, 108-130, 145-167, 236-253 and 273-295 218491020170 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0008 218491020171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491020172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491020173 dimer interface [polypeptide binding]; other site 218491020174 conserved gate region; other site 218491020175 putative PBP binding loops; other site 218491020176 ABC-ATPase subunit interface; other site 218491020177 6 probable transmembrane helices predicted for ECA4075 by TMHMM2.0 at aa 21-43, 110-132, 145-167, 206-228, 268-290 and 310-332 218491020178 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4.8e-09 218491020179 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491020180 Signal peptide predicted for ECA4076 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.840 between residues 27 and 28; signal peptide 218491020181 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 218491020182 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 1.2e-26 218491020183 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 218491020184 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 218491020185 putative active site pocket [active] 218491020186 metal binding site [ion binding]; metal-binding site 218491020187 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 3.5e-05 218491020188 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 1.9e-08 218491020189 PS00215 Mitochondrial energy transfer proteins signature. 218491020190 nitrite reductase subunit NirD; Provisional; Region: PRK14989 218491020191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491020192 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218491020193 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218491020194 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 218491020195 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 1.3e-76 218491020196 HMMPfam hit to PF03460, DE Nitrite/Sulfite reductase ferredoxin-like half domain, score 1e-18 218491020197 HMMPfam hit to PF01077, DE Nitrite and sulphite reductase 4Fe-4S domain, score 2.6e-26 218491020198 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 218491020199 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 218491020200 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491020201 siroheme synthase; Provisional; Region: cysG; PRK10637 218491020202 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 218491020203 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 218491020204 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 218491020205 active site 218491020206 SAM binding site [chemical binding]; other site 218491020207 homodimer interface [polypeptide binding]; other site 218491020208 HMMPfam hit to PF00590, DE Tetrapyrrole (Corrin/Porphyrin) Methylases, score 3.9e-84 218491020209 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 218491020210 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 218491020211 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491020212 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491020213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491020214 dimer interface [polypeptide binding]; other site 218491020215 conserved gate region; other site 218491020216 putative PBP binding loops; other site 218491020217 ABC-ATPase subunit interface; other site 218491020218 3 probable transmembrane helices predicted for ECA4082 by TMHMM2.0 at aa 24-46, 78-100 and 210-229 218491020219 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4.2e-10 218491020220 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491020221 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491020222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491020223 dimer interface [polypeptide binding]; other site 218491020224 conserved gate region; other site 218491020225 putative PBP binding loops; other site 218491020226 ABC-ATPase subunit interface; other site 218491020227 4 probable transmembrane helices predicted for ECA4083 by TMHMM2.0 at aa 28-50, 57-79, 167-186 and 193-215 218491020228 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.5e-13 218491020229 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491020230 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 218491020231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491020232 Walker A/P-loop; other site 218491020233 ATP binding site [chemical binding]; other site 218491020234 Q-loop/lid; other site 218491020235 ABC transporter signature motif; other site 218491020236 Walker B; other site 218491020237 D-loop; other site 218491020238 H-loop/switch region; other site 218491020239 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-62 218491020240 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020241 PS00211 ABC transporters family signature. 218491020242 Signal peptide predicted for ECA4085 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.944 between residues 27 and 28; signal peptide 218491020243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491020244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491020245 substrate binding pocket [chemical binding]; other site 218491020246 membrane-bound complex binding site; other site 218491020247 hinge residues; other site 218491020248 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491020249 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 3.4e-66 218491020250 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 218491020251 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 218491020252 putative metal binding site [ion binding]; other site 218491020253 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 1.6e-08 218491020254 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 218491020255 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 218491020256 active site 218491020257 HIGH motif; other site 218491020258 dimer interface [polypeptide binding]; other site 218491020259 KMSKS motif; other site 218491020260 HMMPfam hit to PF00579, DE tRNA synthetases class I (W and Y), score 3.6e-117 218491020261 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218491020262 phosphoglycolate phosphatase; Provisional; Region: PRK13222 218491020263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491020264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491020265 motif II; other site 218491020266 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 7.2e-39 218491020267 Signal peptide predicted for ECA4089 by SignalP 2.0 HMM (Signal peptide probabilty 0.778) with cleavage site probability 0.490 between residues 19 and 20; signal peptide 218491020268 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 218491020269 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 218491020270 substrate binding site [chemical binding]; other site 218491020271 hexamer interface [polypeptide binding]; other site 218491020272 metal binding site [ion binding]; metal-binding site 218491020273 HMMPfam hit to PF00834, DE Ribulose-phosphate 3 epimerase family, score 6.5e-137 218491020274 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 218491020275 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 218491020276 DNA adenine methylase; Provisional; Region: PRK10904 218491020277 HMMPfam hit to PF02086, DE D12 class N6 adenine-specific DNA methyltransferase, score 6.2e-100 218491020278 PS00092 N-6 Adenine-specific DNA methylases signature. 218491020279 hypothetical protein; Reviewed; Region: PRK11901 218491020280 cell division protein DamX; Validated; Region: PRK10905 218491020281 cell division protein DamX; Validated; Region: PRK10905 218491020282 1 probable transmembrane helix predicted for ECA4091 by TMHMM2.0 at aa 40-62 218491020283 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 218491020284 active site 218491020285 dimer interface [polypeptide binding]; other site 218491020286 metal binding site [ion binding]; metal-binding site 218491020287 HMMPfam hit to PF01761, DE 3-dehydroquinate synthase, score 2.1e-193 218491020288 shikimate kinase; Reviewed; Region: aroK; PRK00131 218491020289 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 218491020290 ADP binding site [chemical binding]; other site 218491020291 magnesium binding site [ion binding]; other site 218491020292 putative shikimate binding site; other site 218491020293 HMMPfam hit to PF01202, DE Shikimate kinase, score 4.7e-87 218491020294 PS01128 Shikimate kinase signature. 218491020295 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020296 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 218491020297 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218491020298 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218491020299 HMMPfam hit to PF00263, DE Bacterial type II and III secretion system protein, score 8.3e-90 218491020300 PS00875 Bacterial type II secretion system protein D signature. 218491020301 Signal peptide predicted for ECA4095 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.991 between residues 21 and 22; signal peptide 218491020302 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 218491020303 1 probable transmembrane helix predicted for ECA4096 by TMHMM2.0 at aa 26-45 218491020304 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 218491020305 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 218491020306 1 probable transmembrane helix predicted for ECA4097 by TMHMM2.0 at aa 21-43 218491020307 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 218491020308 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 218491020309 Signal peptide predicted for ECA4099 by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.394 between residues 19 and 20; signal peptide 218491020310 Transglycosylase; Region: Transgly; pfam00912 218491020311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218491020312 HMMPfam hit to PF00912, DE Transglycosylase, score 6.8e-112 218491020313 HMMPfam hit to PF00905, DE Penicillin binding protein transpeptidase domain, score 3.3e-11 218491020314 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 218491020315 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218491020316 ADP-ribose binding site [chemical binding]; other site 218491020317 dimer interface [polypeptide binding]; other site 218491020318 active site 218491020319 nudix motif; other site 218491020320 metal binding site [ion binding]; metal-binding site 218491020321 HMMPfam hit to PF00293, DE NUDIX domain, score 9.2e-12 218491020322 PS00893 mutT domain signature. 218491020323 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 218491020324 Signal peptide predicted for ECA4102 by SignalP 2.0 HMM (Signal peptide probabilty 0.944) with cleavage site probability 0.488 between residues 19 and 20; signal peptide 218491020325 3 probable transmembrane helices predicted for ECA4102 by TMHMM2.0 at aa 4-23, 207-229 and 654-676 218491020326 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491020327 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 218491020328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491020329 active site 218491020330 motif I; other site 218491020331 motif II; other site 218491020332 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 4.7e-22 218491020333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218491020334 RNA binding surface [nucleotide binding]; other site 218491020335 HMMPfam hit to PF01479, DE S4 domain, score 3.9e-12 218491020336 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 218491020337 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 218491020338 dimerization interface [polypeptide binding]; other site 218491020339 domain crossover interface; other site 218491020340 redox-dependent activation switch; other site 218491020341 HMMPfam hit to PF01430, DE Hsp33 protein, score 5.7e-145 218491020342 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 218491020343 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 218491020344 active site 218491020345 substrate-binding site [chemical binding]; other site 218491020346 metal-binding site [ion binding] 218491020347 ATP binding site [chemical binding]; other site 218491020348 HMMPfam hit to PF01293, DE Phosphoenolpyruvate carboxykinase, score 0 218491020349 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020350 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 218491020351 Signal peptide predicted for ECA4107 by SignalP 2.0 HMM (Signal peptide probabilty 0.959) with cleavage site probability 0.311 between residues 33 and 34; signal peptide 218491020352 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 218491020353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491020354 dimerization interface [polypeptide binding]; other site 218491020355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218491020356 dimer interface [polypeptide binding]; other site 218491020357 phosphorylation site [posttranslational modification] 218491020358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491020359 ATP binding site [chemical binding]; other site 218491020360 Mg2+ binding site [ion binding]; other site 218491020361 G-X-G motif; other site 218491020362 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1e-31 218491020363 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 1.9e-13 218491020364 HMMPfam hit to PF00672, DE HAMP domain, score 8.7e-10 218491020365 2 probable transmembrane helices predicted for ECA4107 by TMHMM2.0 at aa 15-37 and 159-178 218491020366 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218491020367 osmolarity response regulator; Provisional; Region: ompR; PRK09468 218491020368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491020369 active site 218491020370 phosphorylation site [posttranslational modification] 218491020371 intermolecular recognition site; other site 218491020372 dimerization interface [polypeptide binding]; other site 218491020373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491020374 DNA binding site [nucleotide binding] 218491020375 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 1e-34 218491020376 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 6.3e-43 218491020377 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 218491020378 ParB-like nuclease domain; Region: ParB; smart00470 218491020379 Signal peptide predicted for ECA4110 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.749 between residues 30 and 31; signal peptide 218491020380 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 218491020381 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 218491020382 putative ligand binding residues [chemical binding]; other site 218491020383 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 0.00049 218491020384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491020385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491020386 putative substrate translocation pore; other site 218491020387 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0016 218491020388 12 probable transmembrane helices predicted for ECA4111 by TMHMM2.0 at aa 7-26, 46-68, 81-103, 108-130, 137-159, 164-186, 211-233, 253-275, 287-309, 313-332, 345-367 and 372-394 218491020389 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 218491020390 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 218491020391 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 218491020392 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 218491020393 dimer interface [polypeptide binding]; other site 218491020394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491020395 catalytic residue [active] 218491020396 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 2.6e-67 218491020397 Signal peptide predicted for ECA4114 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.874 between residues 18 and 19; signal peptide 218491020398 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 218491020399 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 218491020400 dimer interface [polypeptide binding]; other site 218491020401 active site 218491020402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218491020403 catalytic residues [active] 218491020404 substrate binding site [chemical binding]; other site 218491020405 HMMPfam hit to PF02784, DE Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 4.5e-10 218491020406 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 218491020407 Signal peptide predicted for ECA4115 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.994 between residues 42 and 43; signal peptide 218491020408 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491020409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491020410 N-terminal plug; other site 218491020411 ligand-binding site [chemical binding]; other site 218491020412 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 5.7e-19 218491020413 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491020414 IucA / IucC family; Region: IucA_IucC; pfam04183 218491020415 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 218491020416 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 218491020417 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 218491020418 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 218491020419 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218491020420 HMMPfam hit to PF01272, DE Prokaryotic transcription elongation factor, GreA/GreB, C-terminal domain, score 9.6e-25 218491020421 PS00830 Prokaryotic transcription elongation factors signature 2. 218491020422 HMMPfam hit to PF03449, DE Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain, score 1.5e-35 218491020423 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 218491020424 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 218491020425 putative acyl-acceptor binding pocket; other site 218491020426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 218491020427 HMMPfam hit to PF01553, DE Acyltransferase, score 0.002 218491020428 Signal peptide predicted for ECA4120 by SignalP 2.0 HMM (Signal peptide probabilty 0.850) with cleavage site probability 0.241 between residues 29 and 30; signal peptide 218491020429 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491020430 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491020431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491020432 dimer interface [polypeptide binding]; other site 218491020433 putative CheW interface [polypeptide binding]; other site 218491020434 2 probable transmembrane helices predicted for ECA4120 by TMHMM2.0 at aa 10-29 and 190-212 218491020435 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.1e-91 218491020436 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 218491020437 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 218491020438 dimer interface [polypeptide binding]; other site 218491020439 active site 218491020440 citrylCoA binding site [chemical binding]; other site 218491020441 NADH binding [chemical binding]; other site 218491020442 cationic pore residues; other site 218491020443 oxalacetate/citrate binding site [chemical binding]; other site 218491020444 coenzyme A binding site [chemical binding]; other site 218491020445 catalytic triad [active] 218491020446 HMMPfam hit to PF00285, DE Citrate synthase, score 9.1e-178 218491020447 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 218491020448 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 218491020449 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 218491020450 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 218491020451 RNA binding site [nucleotide binding]; other site 218491020452 HMMPfam hit to PF00575, DE S1 RNA binding domain, score 9.1e-26 218491020453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 218491020454 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 218491020455 Bacterial transcriptional regulator; Region: IclR; pfam01614 218491020456 HMMPfam hit to PF01614, DE Bacterial transcriptional regulator, score 4.4e-44 218491020457 2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812 218491020458 HMMPfam hit to PF03812, DE 2-keto-3-deoxygluconate permease, score 8.5e-248 218491020459 10 probable transmembrane helices predicted for ECA4124 by TMHMM2.0 at aa 12-33, 43-62, 75-97, 107-129, 142-164, 168-187, 194-216, 222-244, 251-273 and 288-310 218491020460 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 218491020461 Signal peptide predicted for ECA4126 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.976 between residues 24 and 25; signal peptide 218491020462 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 218491020463 active site 218491020464 homotetramer interface [polypeptide binding]; other site 218491020465 homodimer interface [polypeptide binding]; other site 218491020466 PS00144 Asparaginase / glutaminase active site signature 1. 218491020467 HMMPfam hit to PF00710, DE Asparaginase, score 4.4e-118 218491020468 PS00917 Asparaginase / glutaminase active site signature 2. 218491020469 Signal peptide predicted for ECA4127 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.303 between residues 32 and 33; signal peptide 218491020470 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218491020471 HMMPfam hit to PF02687, DE Predicted permease, score 2.9e-07 218491020472 4 probable transmembrane helices predicted for ECA4127 by TMHMM2.0 at aa 13-35, 299-321, 341-374 and 394-416 218491020473 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218491020474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218491020475 Walker A/P-loop; other site 218491020476 ATP binding site [chemical binding]; other site 218491020477 Q-loop/lid; other site 218491020478 ABC transporter signature motif; other site 218491020479 Walker B; other site 218491020480 D-loop; other site 218491020481 H-loop/switch region; other site 218491020482 HMMPfam hit to PF00005, DE ABC transporter, score 8.4e-48 218491020483 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020484 Signal peptide predicted for ECA4129 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.971 between residues 36 and 37; signal peptide 218491020485 Signal peptide predicted for ECA4130 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 21 and 22; signal peptide 218491020486 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 218491020487 dimer interface [polypeptide binding]; other site 218491020488 Alkaline phosphatase homologues; Region: alkPPc; smart00098 218491020489 active site 218491020490 HMMPfam hit to PF00245, DE Alkaline phosphatase, score 1.2e-27 218491020491 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 218491020492 Protein export membrane protein; Region: SecD_SecF; cl14618 218491020493 HMMPfam hit to PF00873, DE AcrB/AcrD/AcrF family, score 0 218491020494 11 probable transmembrane helices predicted for ECA4131 by TMHMM2.0 at aa 10-32, 340-362, 366-388, 440-462, 472-494, 540-562, 868-890, 897-919, 924-946, 972-994 and 1004-1026 218491020495 carboxylesterase BioH; Provisional; Region: PRK10349 218491020496 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 3.7e-29 218491020497 DNA utilization protein GntX; Provisional; Region: PRK11595 218491020498 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218491020499 active site 218491020500 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218491020501 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 218491020502 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 218491020503 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 218491020504 HMMPfam hit to PF01521, DE HesB-like domain, score 1.3e-35 218491020505 HMMPfam hit to PF01106, DE NifU-like domain, score 1.7e-06 218491020506 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 218491020507 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 218491020508 HMMPfam hit to PF02446, DE 4-alpha-glucanotransferase, score 2.8e-180 218491020509 maltodextrin phosphorylase; Provisional; Region: PRK14985 218491020510 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 218491020511 active site pocket [active] 218491020512 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00343, DE Carbohydrate phosphorylase, score 0 218491020513 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 218491020514 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 218491020515 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 218491020516 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218491020517 HMMPfam hit to PF00455, DE Bacterial regulatory proteins, deoR family, score 1.1e-110 218491020518 Predicted helix-turn-helix motif with score 1453.000, SD 4.14 at aa 20-41, sequence VSTEELVDHFAVSPQTIRRDLN 218491020519 PS00894 Bacterial regulatory proteins, deoR family signature. 218491020520 intramembrane serine protease GlpG; Provisional; Region: PRK10907 218491020521 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 218491020522 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 218491020523 HMMPfam hit to PF01694, DE Rhomboid family, score 6.9e-36 218491020524 5 probable transmembrane helices predicted for ECA4138 by TMHMM2.0 at aa 95-117, 143-162, 169-191, 195-214 and 235-268 218491020525 PS00214 Cytosolic fatty-acid binding proteins signature. 218491020526 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 218491020527 active site residue [active] 218491020528 HMMPfam hit to PF00581, DE Rhodanese-like domain, score 3.8e-10 218491020529 PS00380 Rhodanese signature 1. 218491020530 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 218491020531 dimer interface [polypeptide binding]; other site 218491020532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218491020533 ligand binding site [chemical binding]; other site 218491020534 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 218491020535 HMMPfam hit to PF01266, DE FAD dependent oxidoreductase, score 1.4e-132 218491020536 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 218491020537 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 218491020538 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218491020539 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218491020540 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218491020541 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 218491020542 PS00217 Sugar transport proteins signature 2. 218491020543 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 218491020544 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 218491020545 1 probable transmembrane helix predicted for ECA4144 by TMHMM2.0 at aa 25-44 218491020546 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020547 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 218491020548 1 probable transmembrane helix predicted for ECA4145 by TMHMM2.0 at aa 25-44 218491020549 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 218491020550 glycogen phosphorylase; Provisional; Region: PRK14986 218491020551 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 218491020552 homodimer interface [polypeptide binding]; other site 218491020553 active site pocket [active] 218491020554 HMMPfam hit to PF00343, DE Carbohydrate phosphorylase, score 0 218491020555 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 218491020556 glycogen synthase; Provisional; Region: glgA; PRK00654 218491020557 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 218491020558 ADP-binding pocket [chemical binding]; other site 218491020559 homodimer interface [polypeptide binding]; other site 218491020560 HMMPfam hit to PF00534, DE Glycosyl transferases group 1, score 4.8e-06 218491020561 PS00589 PTS HPR component serine phosphorylation site signature. 218491020562 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 218491020563 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 218491020564 ligand binding site; other site 218491020565 oligomer interface; other site 218491020566 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 218491020567 dimer interface [polypeptide binding]; other site 218491020568 N-terminal domain interface [polypeptide binding]; other site 218491020569 sulfate 1 binding site; other site 218491020570 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 5.4e-85 218491020571 PS00810 ADP-glucose pyrophosphorylase signature 3. 218491020572 PS00809 ADP-glucose pyrophosphorylase signature 2. 218491020573 PS00808 ADP-glucose pyrophosphorylase signature 1. 218491020574 glycogen debranching enzyme; Provisional; Region: PRK03705 218491020575 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 218491020576 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 218491020577 active site 218491020578 catalytic site [active] 218491020579 HMMPfam hit to PF00128, DE Alpha amylase, catalytic domain, score 8.1e-10 218491020580 HMMPfam hit to PF02922, DE Isoamylase N-terminal domain, score 1.2e-28 218491020581 glycogen branching enzyme; Provisional; Region: PRK05402 218491020582 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 218491020583 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 218491020584 active site 218491020585 catalytic site [active] 218491020586 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 218491020587 HMMPfam hit to PF00128, DE Alpha amylase, catalytic domain, score 1.9e-08 218491020588 HMMPfam hit to PF02922, DE Isoamylase N-terminal domain, score 4.6e-39 218491020589 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 218491020590 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 218491020591 GAF domain; Region: GAF; pfam01590 218491020592 Histidine kinase; Region: His_kinase; pfam06580 218491020593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491020594 ATP binding site [chemical binding]; other site 218491020595 Mg2+ binding site [ion binding]; other site 218491020596 G-X-G motif; other site 218491020597 5 probable transmembrane helices predicted for ECA4152 by TMHMM2.0 at aa 17-36, 51-73, 86-108, 113-135 and 147-169 218491020598 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 4.6e-07 218491020599 HipA N-terminal domain; Region: Couple_hipA; cl11853 218491020600 HipA-like N-terminal domain; Region: HipA_N; pfam07805 218491020601 HipA-like C-terminal domain; Region: HipA_C; pfam07804 218491020602 PS00238 Visual pigments (opsins) retinal binding site. 218491020603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491020604 sequence-specific DNA binding site [nucleotide binding]; other site 218491020605 salt bridge; other site 218491020606 HMMPfam hit to PF01381, DE Helix-turn-helix, score 4.3e-09 218491020607 Predicted helix-turn-helix motif with score 1834.000, SD 5.43 at aa 29-50, sequence MTQSDVAARSGIGVNTVSNLES 218491020608 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 218491020609 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218491020610 HMMPfam hit to PF02774, DE Semialdehyde dehydrogenase, dimerisation domain, score 4e-82 218491020611 PS01103 Aspartate-semialdehyde dehydrogenase signature. 218491020612 HMMPfam hit to PF01118, DE Semialdehyde dehydrogenase, NAD binding domain, score 3.2e-41 218491020613 putative antibiotic transporter; Provisional; Region: PRK10739 218491020614 HMMPfam hit to PF01914, DE MarC family integral membrane protein, score 1.7e-74 218491020615 6 probable transmembrane helices predicted for ECA4157 by TMHMM2.0 at aa 7-28, 43-65, 72-90, 105-127, 140-159 and 174-191 218491020616 Signal peptide predicted for ECA4158 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.433 between residues 35 and 36; signal peptide 218491020617 fructuronate transporter; Provisional; Region: PRK10034; cl15264 218491020618 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 218491020619 13 probable transmembrane helices predicted for ECA4158 by TMHMM2.0 at aa 4-26, 33-50, 60-82, 111-133, 143-165, 177-199, 238-260, 273-295, 310-332, 337-359, 369-391, 398-420 and 435-457 218491020620 HMMPfam hit to PF02447, DE GntP family permease, score 1.9e-127 218491020621 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 218491020622 ATP-binding site [chemical binding]; other site 218491020623 Gluconate-6-phosphate binding site [chemical binding]; other site 218491020624 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491020626 DNA binding site [nucleotide binding] 218491020627 domain linker motif; other site 218491020628 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 218491020629 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 218491020630 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 218491020631 HMMPfam hit to PF00933, DE Glycosyl hydrolase family 3 N terminal domain, score 6e-55 218491020632 PS00775 Glycosyl hydrolases family 3 active site. 218491020633 Pirin-related protein [General function prediction only]; Region: COG1741 218491020634 Pirin; Region: Pirin; pfam02678 218491020635 HMMPfam hit to PF02678, DE Pirin, score 2.8e-148 218491020636 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491020637 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 218491020638 Cysteine-rich domain; Region: CCG; pfam02754 218491020639 Cysteine-rich domain; Region: CCG; pfam02754 218491020640 HMMPfam hit to PF02754, DE Cysteine-rich domain, score 3.8e-15 218491020641 HMMPfam hit to PF02754, DE Cysteine-rich domain, score 6.8e-07 218491020642 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 0.023 218491020643 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491020644 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491020645 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 218491020646 Signal peptide predicted for ECA4164 by SignalP 2.0 HMM (Signal peptide probabilty 0.722) with cleavage site probability 0.722 between residues 22 and 23; signal peptide 218491020647 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 218491020648 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 218491020649 hydroxyglutarate oxidase; Provisional; Region: PRK11728 218491020650 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 218491020651 HMMPfam hit to PF01266, DE FAD dependent oxidoreductase, score 6e-121 218491020652 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 218491020653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491020654 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 218491020655 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 218491020656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491020657 putative substrate translocation pore; other site 218491020658 12 probable transmembrane helices predicted for ECA4166 by TMHMM2.0 at aa 26-45, 65-87, 94-116, 120-142, 161-183, 188-207, 254-273, 293-312, 319-341, 351-373, 385-407 and 417-436 218491020659 PS00942 glpT family of transporters signature. 218491020660 Signal peptide predicted for ECA4167 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.442 between residues 24 and 25; signal peptide 218491020661 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 218491020662 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 218491020663 active site 218491020664 catalytic site [active] 218491020665 metal binding site [ion binding]; metal-binding site 218491020666 HMMPfam hit to PF03009, DE Glycerophosphoryl diester phosphodiesterase family, score 1.7e-90 218491020667 putative hydrolase; Provisional; Region: PRK10976 218491020668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491020669 active site 218491020670 motif I; other site 218491020671 motif II; other site 218491020672 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491020673 PS01229 Hypothetical cof family signature 2. 218491020674 lysophospholipase L2; Provisional; Region: PRK10749 218491020675 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218491020676 HMMPfam hit to PF00561, DE alpha/beta hydrolase fold, score 1.4e-16 218491020677 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 218491020678 5 probable transmembrane helices predicted for ECA4170 by TMHMM2.0 at aa 35-57, 72-94, 145-167, 172-194 and 214-232 218491020679 HMMPfam hit to PF01810, DE LysE type translocator, score 7.7e-35 218491020680 threonine efflux system; Provisional; Region: PRK10229 218491020681 Signal peptide predicted for ECA4171 by SignalP 2.0 HMM (Signal peptide probabilty 0.681) with cleavage site probability 0.184 between residues 30 and 31; signal peptide 218491020682 6 probable transmembrane helices predicted for ECA4171 by TMHMM2.0 at aa 5-27, 40-62, 67-86, 120-142, 152-174 and 187-206 218491020683 HMMPfam hit to PF01810, DE LysE type translocator, score 1.1e-27 218491020684 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 218491020685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491020686 ATP binding site [chemical binding]; other site 218491020687 putative Mg++ binding site [ion binding]; other site 218491020688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491020689 nucleotide binding region [chemical binding]; other site 218491020690 ATP-binding site [chemical binding]; other site 218491020691 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 218491020692 Helicase and RNase D C-terminal; Region: HRDC; smart00341 218491020693 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00570, DE HRDC domain, score 1.7e-27 218491020694 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 1.4e-26 218491020695 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 2.1e-40 218491020696 Signal peptide predicted for ECA4173 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 18 and 19; signal peptide 218491020697 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 218491020698 dimerization interface [polypeptide binding]; other site 218491020699 substrate binding site [chemical binding]; other site 218491020700 active site 218491020701 calcium binding site [ion binding]; other site 218491020702 HMMPfam hit to PF02253, DE Phospholipase A1, score 3.6e-146 218491020703 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218491020704 CoenzymeA binding site [chemical binding]; other site 218491020705 subunit interaction site [polypeptide binding]; other site 218491020706 PHB binding site; other site 218491020707 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 218491020708 EamA-like transporter family; Region: EamA; cl17759 218491020709 10 probable transmembrane helices predicted for ECA4175 by TMHMM2.0 at aa 9-28, 38-60, 72-94, 104-121, 128-145, 150-167, 180-197, 212-234, 239-261 and 271-290 218491020710 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 1e-12 218491020711 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 0.039 218491020712 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 218491020713 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 218491020714 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 218491020715 10 probable transmembrane helices predicted for ECA4176 by TMHMM2.0 at aa 7-24, 29-51, 58-80, 85-107, 148-167, 182-201, 208-230, 234-256, 263-285 and 321-343 218491020716 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 218491020717 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 218491020718 Cl binding site [ion binding]; other site 218491020719 oligomer interface [polypeptide binding]; other site 218491020720 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01544, DE CorA-like Mg2+ transporter protein, score 1.4e-112 218491020721 2 probable transmembrane helices predicted for ECA4177 by TMHMM2.0 at aa 255-273 and 288-310 218491020722 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 218491020723 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218491020724 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 218491020725 Part of AAA domain; Region: AAA_19; pfam13245 218491020726 Family description; Region: UvrD_C_2; pfam13538 218491020727 HMMPfam hit to PF00580, DE UvrD/REP helicase, score 3.8e-197 218491020728 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020729 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 218491020730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491020731 motif II; other site 218491020732 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 6.5e-22 218491020733 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218491020734 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 218491020735 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491020736 active site 218491020737 DNA binding site [nucleotide binding] 218491020738 Int/Topo IB signature motif; other site 218491020739 HMMPfam hit to PF00589, DE Phage integrase family, score 7.5e-60 218491020740 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 4.7e-26 218491020741 hypothetical protein; Provisional; Region: PRK10963 218491020742 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 218491020743 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 218491020744 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 218491020745 HMMPfam hit to PF01678, DE Diaminopimelate epimerase, score 2.1e-50 218491020746 HMMPfam hit to PF01678, DE Diaminopimelate epimerase, score 3.1e-53 218491020747 PS01326 Diaminopimelate epimerase signature. 218491020748 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 218491020749 1 probable transmembrane helix predicted for ECA4184 by TMHMM2.0 at aa 13-35 218491020750 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491020751 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 218491020752 putative iron binding site [ion binding]; other site 218491020753 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01491, DE Frataxin-like domain, score 2.3e-66 218491020754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491020755 12 probable transmembrane helices predicted for ECA4186 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-123, 136-155, 165-187, 214-236, 251-273, 280-302, 307-329, 341-363 and 367-389 218491020756 adenylate cyclase; Provisional; Region: cyaA; PRK09450 218491020757 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 218491020758 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 218491020759 HMMPfam hit to PF01295, DE Adenylate cyclase, class-I, score 0 218491020760 PS01093 Adenylate cyclases class-I signature 2. 218491020761 PS01092 Adenylate cyclases class-I signature 1. 218491020762 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 218491020763 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 218491020764 domain interfaces; other site 218491020765 active site 218491020766 HMMPfam hit to PF01379, DE Porphobilinogen deaminase, dipyromethane cofactor binding domain, score 1.6e-138 218491020767 HMMPfam hit to PF03900, DE Porphobilinogen deaminase, C-terminal domain, score 1.4e-29 218491020768 PS00533 Porphobilinogen deaminase cofactor-binding site. 218491020769 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 218491020770 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 218491020771 active site 218491020772 HMMPfam hit to PF02602, DE Uroporphyrinogen-III synthase HemD, score 1.4e-45 218491020773 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 218491020774 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 218491020775 1 probable transmembrane helix predicted for ECA4190 by TMHMM2.0 at aa 35-57 218491020776 Signal peptide predicted for ECA4191 by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.593 between residues 22 and 23; signal peptide 218491020777 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 218491020778 HemY protein N-terminus; Region: HemY_N; pfam07219 218491020779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218491020780 TPR motif; other site 218491020781 binding surface 218491020782 2 probable transmembrane helices predicted for ECA4191 by TMHMM2.0 at aa 5-27 and 40-62 218491020783 PS00215 Mitochondrial energy transfer proteins signature. 218491020784 HMMPfam hit to PF00515, DE TPR Domain, score 0.016 218491020785 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 218491020786 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 218491020787 metal binding site [ion binding]; metal-binding site 218491020788 dimer interface [polypeptide binding]; other site 218491020789 HMMPfam hit to PF01546, DE Peptidase family M20/M25/M40, score 2.3e-76 218491020790 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491020791 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491020792 Walker A/P-loop; other site 218491020793 ATP binding site [chemical binding]; other site 218491020794 Q-loop/lid; other site 218491020795 ABC transporter signature motif; other site 218491020796 Walker B; other site 218491020797 D-loop; other site 218491020798 H-loop/switch region; other site 218491020799 HMMPfam hit to PF00005, DE ABC transporter, score 7e-65 218491020800 PS00211 ABC transporters family signature. 218491020801 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491020803 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491020804 dimer interface [polypeptide binding]; other site 218491020805 conserved gate region; other site 218491020806 putative PBP binding loops; other site 218491020807 ABC-ATPase subunit interface; other site 218491020808 3 probable transmembrane helices predicted for ECA4194 by TMHMM2.0 at aa 20-42, 63-85 and 191-213 218491020809 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 5.4e-14 218491020810 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491020811 Predicted helix-turn-helix motif with score 1274.000, SD 3.53 at aa 123-144, sequence FGQTEAGLSIGMSKAQVYRRIV 218491020812 Signal peptide predicted for ECA4195 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.773 between residues 20 and 21; signal peptide 218491020813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491020814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491020815 substrate binding pocket [chemical binding]; other site 218491020816 membrane-bound complex binding site; other site 218491020817 hinge residues; other site 218491020818 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 6.2e-59 218491020819 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491020820 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020821 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491020822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 218491020823 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.2e-10 218491020824 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 218491020825 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 218491020826 tetramer interface [polypeptide binding]; other site 218491020827 active site 218491020828 HMMPfam hit to PF00206, DE Lyase, score 4.4e-35 218491020829 PS00163 Fumarate lyases signature. 218491020830 Signal peptide predicted for ECA4198 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.533 between residues 27 and 28; signal peptide 218491020831 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 218491020832 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 218491020833 catalytic core [active] 218491020834 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 218491020835 HMMPfam hit to PF00328, DE Histidine acid phosphatase, score 1.4e-09 218491020836 PS00616 Histidine acid phosphatases phosphohistidine signature. 218491020837 putative transport protein YifK; Provisional; Region: PRK10746 218491020838 HMMPfam hit to PF00324, DE Amino acid permease, score 3.4e-145 218491020839 12 probable transmembrane helices predicted for ECA4199 by TMHMM2.0 at aa 21-38, 42-61, 95-117, 127-149, 156-178, 193-215, 241-263, 273-295, 329-351, 361-383, 403-425 and 430-452 218491020840 PS00218 Amino acid permeases signature. 218491020841 Enterobacterial common antigen (ECA) biosynthesis cluster 218491020842 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 218491020843 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 218491020844 HMMPfam hit to PF03808, DE Glycosyl transferase WecB/TagA/CpsF family, score 2e-84 218491020845 putative common antigen polymerase; Provisional; Region: PRK02975 218491020846 11 probable transmembrane helices predicted for ECA4201 by TMHMM2.0 at aa 4-26, 38-60, 70-89, 110-132, 152-174, 181-200, 204-223, 225-244, 337-359, 380-397 and 407-429 218491020847 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 218491020848 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 218491020849 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 218491020850 12 probable transmembrane helices predicted for ECA4203 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 117-139, 146-168, 173-195, 216-238, 263-280, 301-323, 333-355, 362-384 and 390-412 218491020851 HMMPfam hit to PF01943, DE Polysaccharide biosynthesis protein, score 0.00072 218491020852 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 218491020853 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 218491020854 inhibitor-cofactor binding pocket; inhibition site 218491020855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491020856 catalytic residue [active] 218491020857 HMMPfam hit to PF01041, DE DegT/DnrJ/EryC1/StrS aminotransferase family, score 1.7e-85 218491020858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 218491020859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491020860 Coenzyme A binding pocket [chemical binding]; other site 218491020861 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.2e-11 218491020862 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 218491020863 Signal peptide predicted for ECA4206 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.977 between residues 23 and 24; signal peptide 218491020864 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 218491020865 NAD binding site [chemical binding]; other site 218491020866 substrate binding site [chemical binding]; other site 218491020867 homodimer interface [polypeptide binding]; other site 218491020868 active site 218491020869 HMMPfam hit to PF01370, DE NAD dependent epimerase/dehydratase family, score 3.3e-212 218491020870 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 218491020871 Signal peptide predicted for ECA4207 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.899 between residues 23 and 24; signal peptide 218491020872 TrkA-N domain; Region: TrkA_N; pfam02254 218491020873 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 218491020874 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 218491020875 HMMPfam hit to PF03720, DE UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain, score 2e-21 218491020876 HMMPfam hit to PF00984, DE UDP-glucose/GDP-mannose dehydrogenase family, central domain, score 7.4e-43 218491020877 HMMPfam hit to PF03721, DE UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain, score 3.2e-83 218491020878 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 218491020879 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 218491020880 active site 218491020881 homodimer interface [polypeptide binding]; other site 218491020882 HMMPfam hit to PF02350, DE UDP-N-acetylglucosamine 2-epimerase, score 8.5e-203 218491020883 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 218491020884 Chain length determinant protein; Region: Wzz; pfam02706 218491020885 2 probable transmembrane helices predicted for ECA4209 by TMHMM2.0 at aa 32-51 and 325-344 218491020886 HMMPfam hit to PF02706, DE Chain length determinant protein, score 1.1e-05 218491020887 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 218491020888 Signal peptide predicted for ECA4210 by SignalP 2.0 HMM (Signal peptide probabilty 0.940) with cleavage site probability 0.622 between residues 23 and 24; signal peptide 218491020889 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 218491020890 Mg++ binding site [ion binding]; other site 218491020891 putative catalytic motif [active] 218491020892 substrate binding site [chemical binding]; other site 218491020893 11 probable transmembrane helices predicted for ECA4210 by TMHMM2.0 at aa 5-24, 41-60, 65-84, 96-118, 128-150, 155-174, 179-201, 208-230, 240-258, 289-311 and 316-333 218491020894 HMMPfam hit to PF00953, DE Glycosyl transferase, score 8e-09 218491020895 transcription termination factor Rho; Provisional; Region: rho; PRK09376 218491020896 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 218491020897 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 218491020898 RNA binding site [nucleotide binding]; other site 218491020899 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 218491020900 multimer interface [polypeptide binding]; other site 218491020901 Walker A motif; other site 218491020902 ATP binding site [chemical binding]; other site 218491020903 Walker B motif; other site 218491020904 HMMPfam hit to PF00006, DE ATP synthase alpha/beta family, nucleotide-binding domain, score 2.3e-82 218491020905 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020906 PS00464 Ribosomal protein L22 signature. 218491020907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218491020908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218491020909 catalytic residues [active] 218491020910 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00085, DE Thioredoxin, score 2e-43 218491020911 PS00194 Thioredoxin family active site. 218491020912 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 218491020913 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218491020914 ATP binding site [chemical binding]; other site 218491020915 Mg++ binding site [ion binding]; other site 218491020916 motif III; other site 218491020917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218491020918 nucleotide binding region [chemical binding]; other site 218491020919 ATP-binding site [chemical binding]; other site 218491020920 HMMPfam hit to PF00270, DE DEAD/DEAH box helicase, score 1.1e-70 218491020921 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020922 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218491020923 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 8.2e-32 218491020924 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491020925 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 218491020926 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 218491020927 HMMPfam hit to PF02541, DE Ppx/GppA phosphatase family, score 3.9e-125 218491020928 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 218491020929 Part of AAA domain; Region: AAA_19; pfam13245 218491020930 Family description; Region: UvrD_C_2; pfam13538 218491020931 HMMPfam hit to PF00580, DE UvrD/REP helicase, score 1.7e-215 218491020932 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020933 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 218491020934 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 218491020935 HMMPfam hit to PF00639, DE PPIC-type PPIASE domain, score 2.8e-34 218491020936 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 218491020937 Predicted transcriptional regulator [Transcription]; Region: COG3905 218491020938 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 218491020939 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 218491020940 Glutamate binding site [chemical binding]; other site 218491020941 NAD binding site [chemical binding]; other site 218491020942 catalytic residues [active] 218491020943 HMMPfam hit to PF00171, DE Aldehyde dehydrogenase family, score 7.1e-101 218491020944 PS00070 Aldehyde dehydrogenases cysteine active site. 218491020945 PS00687 Aldehyde dehydrogenases glutamic acid active site. 218491020946 HMMPfam hit to PF01619, DE Proline dehydrogenase, score 8e-179 218491020947 Signal peptide predicted for ECA4218 by SignalP 2.0 HMM (Signal peptide probabilty 0.707) with cleavage site probability 0.618 between residues 27 and 28; signal peptide 218491020948 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 218491020949 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 218491020950 Na binding site [ion binding]; other site 218491020951 12 probable transmembrane helices predicted for ECA4218 by TMHMM2.0 at aa 7-29, 66-88, 124-146, 161-183, 196-218, 233-255, 276-298, 313-335, 372-391, 401-423, 428-450 and 455-473 218491020952 HMMPfam hit to PF00474, DE Sodium:solute symporter family, score 1.6e-195 218491020953 PS00456 Sodium:solute symporter family signature 1. 218491020954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491020955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491020956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491020957 dimerization interface [polypeptide binding]; other site 218491020958 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03466, DE LysR substrate binding domain, score 3.6e-46 218491020959 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.2e-16 218491020960 PS00044 Bacterial regulatory proteins, lysR family signature. 218491020961 Predicted helix-turn-helix motif with score 1100.000, SD 2.93 at aa 17-38, sequence GSFVAAAEVLGISPQMVAKQVA 218491020962 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 218491020963 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 218491020964 ketol-acid reductoisomerase; Validated; Region: PRK05225 218491020965 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 218491020966 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 218491020967 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 218491020968 HMMPfam hit to PF01450, DE Acetohydroxy acid isomeroreductase, catalytic domain, score 7.4e-131 218491020969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491020970 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 218491020971 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 218491020972 putative dimerization interface [polypeptide binding]; other site 218491020973 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 3.8e-26 218491020974 Predicted helix-turn-helix motif with score 2064.000, SD 6.22 at aa 16-37, sequence RHFGRTAKAMHISPSTLSRQIQ 218491020975 PS00044 Bacterial regulatory proteins, lysR family signature. 218491020976 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF03466, DE LysR substrate binding domain, score 7.5e-30 218491020977 Signal peptide predicted for ECA4223 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25; signal peptide 218491020978 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 218491020979 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 218491020980 threonine dehydratase; Reviewed; Region: PRK09224 218491020981 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218491020982 tetramer interface [polypeptide binding]; other site 218491020983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491020984 catalytic residue [active] 218491020985 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 218491020986 putative Ile/Val binding site [chemical binding]; other site 218491020987 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 218491020988 putative Ile/Val binding site [chemical binding]; other site 218491020989 HMMPfam hit to PF00585, DE C-terminal regulatory domain of Threonine dehydratase, score 2.6e-38 218491020990 HMMPfam hit to PF00585, DE C-terminal regulatory domain of Threonine dehydratase, score 2.4e-43 218491020991 HMMPfam hit to PF00291, DE Pyridoxal-phosphate dependent enzyme, score 1.5e-94 218491020992 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218491020993 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 218491020994 HMMPfam hit to PF00920, DE Dehydratase family, score 0 218491020995 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 218491020996 PS00017 ATP/GTP-binding site motif A (P-loop). 218491020997 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 218491020998 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 218491020999 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 218491021000 homodimer interface [polypeptide binding]; other site 218491021001 substrate-cofactor binding pocket; other site 218491021002 catalytic residue [active] 218491021003 HMMPfam hit to PF01063, DE Aminotransferase class IV, score 3e-137 218491021004 PS00770 Aminotransferases class-IV signature. 218491021005 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 218491021006 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 218491021007 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218491021008 PYR/PP interface [polypeptide binding]; other site 218491021009 dimer interface [polypeptide binding]; other site 218491021010 TPP binding site [chemical binding]; other site 218491021011 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218491021012 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218491021013 TPP-binding site [chemical binding]; other site 218491021014 dimer interface [polypeptide binding]; other site 218491021015 HMMPfam hit to PF02775, DE Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 1.2e-85 218491021016 PS00187 Thiamine pyrophosphate enzymes signature. 218491021017 HMMPfam hit to PF00205, DE Thiamine pyrophosphate enzyme, central domain, score 6.3e-66 218491021018 HMMPfam hit to PF02776, DE Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 1.6e-98 218491021019 PS00044 Bacterial regulatory proteins, lysR family signature. 218491021020 putative ATP-dependent protease; Provisional; Region: PRK09862 218491021021 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 218491021022 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 218491021023 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 218491021024 HMMPfam hit to PF01078, DE Magnesium chelatase, subunit ChlI, score 9.1e-89 218491021025 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021026 Predicted helix-turn-helix motif with score 1086.000, SD 2.89 at aa 447-468, sequence AYLEDVMNKLGLSVRAWHRILK 218491021027 hypothetical protein; Provisional; Region: PRK11027 218491021028 transcriptional regulator HdfR; Provisional; Region: PRK03601 218491021029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491021030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491021031 dimerization interface [polypeptide binding]; other site 218491021032 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.3e-24 218491021033 Predicted helix-turn-helix motif with score 1285.000, SD 3.56 at aa 36-57, sequence RHFGRAAESLYLTQSAVSFRIR 218491021034 PS00044 Bacterial regulatory proteins, lysR family signature. 218491021035 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 2.5e-20 218491021036 Signal peptide predicted for ECA4233 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.901 between residues 30 and 31; signal peptide 218491021037 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491021038 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491021039 TM-ABC transporter signature motif; other site 218491021040 9 probable transmembrane helices predicted for ECA4233 by TMHMM2.0 at aa 7-29, 44-61, 63-85, 90-109, 114-136, 159-181, 210-232, 252-274 and 295-317 218491021041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491021042 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218491021043 TM-ABC transporter signature motif; other site 218491021044 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 0.0022 218491021045 8 probable transmembrane helices predicted for ECA4234 by TMHMM2.0 at aa 23-45, 65-87, 108-130, 171-193, 222-244, 254-273, 280-302 and 306-328 218491021046 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 218491021047 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 218491021048 Walker A/P-loop; other site 218491021049 ATP binding site [chemical binding]; other site 218491021050 Q-loop/lid; other site 218491021051 ABC transporter signature motif; other site 218491021052 Walker B; other site 218491021053 D-loop; other site 218491021054 H-loop/switch region; other site 218491021055 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 218491021056 HMMPfam hit to PF00005, DE ABC transporter, score 5.6e-25 218491021057 PS00211 ABC transporters family signature. 218491021058 HMMPfam hit to PF00005, DE ABC transporter, score 5.6e-60 218491021059 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021060 Signal peptide predicted for ECA4236 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 21 and 22; signal peptide 218491021061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 218491021062 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 218491021063 putative ligand binding site [chemical binding]; other site 218491021064 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 7.9e-05 218491021065 glutamate racemase; Provisional; Region: PRK00865 218491021066 HMMPfam hit to PF01177, DE Asp/Glu/Hydantoin racemase, score 2.7e-97 218491021067 PS00924 Aspartate and glutamate racemases signature 2. 218491021068 PS00923 Aspartate and glutamate racemases signature 1. 218491021069 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 218491021070 Signal peptide predicted for ECA4238 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 20 and 21; signal peptide 218491021071 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491021072 N-terminal plug; other site 218491021073 ligand-binding site [chemical binding]; other site 218491021074 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00593, DE TonB dependent receptor, score 1e-21 218491021075 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS01156 TonB-dependent receptor proteins signature 2. 218491021076 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 218491021077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491021078 S-adenosylmethionine binding site [chemical binding]; other site 218491021079 PS01230 RNA methyltransferase trmA family signature 1. 218491021080 PS01231 RNA methyltransferase trmA family signature 2. 218491021081 hypothetical protein; Provisional; Region: PRK11056 218491021082 Signal peptide predicted for ECA4240 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.981 between residues 27 and 28; signal peptide 218491021083 4 probable transmembrane helices predicted for ECA4240 by TMHMM2.0 at aa 12-29, 33-51, 64-83 and 87-109 218491021084 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 218491021085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 218491021086 HMMPfam hit to PF00440, DE Bacterial regulatory proteins, tetR family, score 3.8e-11 218491021087 Predicted helix-turn-helix motif with score 1809.000, SD 5.35 at aa 36-57, sequence LSLREVAREAGIAPTSFYRHFR 218491021088 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 218491021089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491021090 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218491021091 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 1.5e-70 218491021092 HMMPfam hit to PF02852, DE Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 2.8e-36 218491021093 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 218491021094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491021095 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 218491021096 dimerization interface [polypeptide binding]; other site 218491021097 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.2e-59 218491021098 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 1.4e-26 218491021099 PS00044 Bacterial regulatory proteins, lysR family signature. 218491021100 Predicted helix-turn-helix motif with score 1674.000, SD 4.89 at aa 16-37, sequence RHFRRAADSCHVSQPTLSGQIR 218491021101 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 218491021102 FAD binding site [chemical binding]; other site 218491021103 HMMPfam hit to PF02219, DE Methylenetetrahydrofolate reductase, score 2.8e-169 218491021104 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 218491021105 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 218491021106 active site 218491021107 metal binding site [ion binding]; metal-binding site 218491021108 hexamer interface [polypeptide binding]; other site 218491021109 HMMPfam hit to PF00149, DE Calcineurin-like phosphoesterase, score 9.6e-14 218491021110 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491021111 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491021112 domain linker motif; other site 218491021113 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 218491021114 putative dimerization interface [polypeptide binding]; other site 218491021115 putative ligand binding site [chemical binding]; other site 218491021116 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 0.00015 218491021117 PS00678 Trp-Asp (WD) repeats signature. 218491021118 Predicted helix-turn-helix motif with score 2007.000, SD 6.02 at aa 9-30, sequence VSAQDVARRAGVSRSAVSRSFT 218491021119 Signal peptide predicted for ECA4247 by SignalP 2.0 HMM (Signal peptide probabilty 0.841) with cleavage site probability 0.486 between residues 26 and 27; signal peptide 218491021120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021121 dimer interface [polypeptide binding]; other site 218491021122 conserved gate region; other site 218491021123 putative PBP binding loops; other site 218491021124 ABC-ATPase subunit interface; other site 218491021125 6 probable transmembrane helices predicted for ECA4247 by TMHMM2.0 at aa 12-34, 70-92, 99-121, 136-158, 178-200 and 232-254 218491021126 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 3e-17 218491021127 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491021128 Signal peptide predicted for ECA4248 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.497 between residues 22 and 23; signal peptide 218491021129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021130 dimer interface [polypeptide binding]; other site 218491021131 conserved gate region; other site 218491021132 putative PBP binding loops; other site 218491021133 ABC-ATPase subunit interface; other site 218491021134 6 probable transmembrane helices predicted for ECA4248 by TMHMM2.0 at aa 12-34, 67-89, 101-123, 152-174, 207-229 and 249-271 218491021135 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.0018 218491021136 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491021137 Signal peptide predicted for ECA4249 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.982 between residues 20 and 21; signal peptide 218491021138 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 218491021139 hypothetical protein; Provisional; Region: PRK11622 218491021140 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 4.9e-05 218491021141 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 218491021142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491021143 Walker A/P-loop; other site 218491021144 ATP binding site [chemical binding]; other site 218491021145 Q-loop/lid; other site 218491021146 ABC transporter signature motif; other site 218491021147 Walker B; other site 218491021148 D-loop; other site 218491021149 H-loop/switch region; other site 218491021150 HMMPfam hit to PF00005, DE ABC transporter, score 1.9e-65 218491021151 PS00211 ABC transporters family signature. 218491021152 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021153 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 218491021154 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 218491021155 putative catalytic residues [active] 218491021156 putative nucleotide binding site [chemical binding]; other site 218491021157 putative aspartate binding site [chemical binding]; other site 218491021158 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 218491021159 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 218491021160 HMMPfam hit to PF00742, DE Homoserine dehydrogenase, score 2.6e-89 218491021161 PS01042 Homoserine dehydrogenase signature. 218491021162 HMMPfam hit to PF03447, DE Homoserine dehydrogenase, NAD binding domain, score 4.1e-44 218491021163 HMMPfam hit to PF00696, DE Amino acid kinase family, score 1e-45 218491021164 PS00324 Aspartokinase signature. 218491021165 cystathionine gamma-synthase; Provisional; Region: PRK08045 218491021166 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218491021167 homodimer interface [polypeptide binding]; other site 218491021168 substrate-cofactor binding pocket; other site 218491021169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491021170 catalytic residue [active] 218491021171 HMMPfam hit to PF01053, DE Cys/Met metabolism PLP-dependent enzyme, score 1.8e-214 218491021172 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 218491021173 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 218491021174 dimerization interface [polypeptide binding]; other site 218491021175 DNA binding site [nucleotide binding] 218491021176 corepressor binding sites; other site 218491021177 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF01340, DE Met Apo-repressor, MetJ, score 3.6e-84 218491021178 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218491021179 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 218491021180 Walker A/P-loop; other site 218491021181 ATP binding site [chemical binding]; other site 218491021182 Q-loop/lid; other site 218491021183 ABC transporter signature motif; other site 218491021184 Walker B; other site 218491021185 D-loop; other site 218491021186 H-loop/switch region; other site 218491021187 HMMPfam hit to PF00005, DE ABC transporter, score 3.2e-55 218491021188 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021189 PS00211 ABC transporters family signature. 218491021190 Signal peptide predicted for ECA4255 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.989 between residues 19 and 20; signal peptide 218491021191 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 218491021192 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 218491021193 putative ligand binding residues [chemical binding]; other site 218491021194 HMMPfam hit to PF01497, DE Periplasmic binding protein, score 2e-18 218491021195 Signal peptide predicted for ECA4256 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.373 between residues 27 and 28; signal peptide 218491021196 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 218491021197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218491021198 ABC-ATPase subunit interface; other site 218491021199 dimer interface [polypeptide binding]; other site 218491021200 putative PBP binding regions; other site 218491021201 8 probable transmembrane helices predicted for ECA4256 by TMHMM2.0 at aa 5-27, 58-80, 92-109, 119-141, 148-170, 190-212, 241-263 and 309-328 218491021202 HMMPfam hit to PF01032, DE FecCD transport family, score 1.8e-66 218491021203 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 218491021204 HMMPfam hit to PF01197, DE Ribosomal protein L31, score 1.7e-41 218491021205 PS01143 Ribosomal protein L31 signature. 218491021206 PS00190 Cytochrome c family heme-binding site signature. 218491021207 primosome assembly protein PriA; Validated; Region: PRK05580 218491021208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218491021209 ATP binding site [chemical binding]; other site 218491021210 putative Mg++ binding site [ion binding]; other site 218491021211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 218491021212 PS00211 ABC transporters family signature. 218491021213 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021214 HMMPfam hit to PF00271, DE Helicase conserved C-terminal domain, score 4.6e-05 218491021215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491021216 DNA binding site [nucleotide binding] 218491021217 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 218491021218 domain linker motif; other site 218491021219 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 218491021220 dimerization interface [polypeptide binding]; other site 218491021221 ligand binding site [chemical binding]; other site 218491021222 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 3.8e-09 218491021223 Predicted helix-turn-helix motif with score 1450.000, SD 4.13 at aa 10-31, sequence ATMKNVADEAGVSTATVSRTLM 218491021224 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 1.6e-25 218491021225 Signal peptide predicted for ECA4260 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.498 between residues 41 and 42; signal peptide 218491021226 essential cell division protein FtsN; Provisional; Region: PRK10927 218491021227 cell division protein FtsN; Provisional; Region: PRK12757 218491021228 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 218491021229 active site 218491021230 HslU subunit interaction site [polypeptide binding]; other site 218491021231 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 218491021232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491021233 Walker A motif; other site 218491021234 ATP binding site [chemical binding]; other site 218491021235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491021236 Walker B motif; other site 218491021237 arginine finger; other site 218491021238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 218491021239 HMMPfam hit to PF00004, DE ATPase family associated with various cellular activities (AAA), score 1.5e-05 218491021240 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021241 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 218491021242 UbiA prenyltransferase family; Region: UbiA; pfam01040 218491021243 HMMPfam hit to PF01040, DE UbiA prenyltransferase family, score 1.6e-37 218491021244 5 probable transmembrane helices predicted for ECA4263 by TMHMM2.0 at aa 136-155, 162-179, 189-211, 218-237 and 280-302 218491021245 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 218491021246 HMMPfam hit to PF03737, DE Dimethylmenaquinone methyltransferase, score 1.8e-73 218491021247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 218491021248 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 218491021249 amphipathic channel; other site 218491021250 Asn-Pro-Ala signature motifs; other site 218491021251 HMMPfam hit to PF00230, DE Major intrinsic protein, score 4.3e-122 218491021252 6 probable transmembrane helices predicted for ECA4266 by TMHMM2.0 at aa 13-32, 47-69, 89-111, 145-167, 180-202 and 235-257 218491021253 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021254 PS00221 MIP family signature. 218491021255 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021256 glycerol kinase; Provisional; Region: glpK; PRK00047 218491021257 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 218491021258 N- and C-terminal domain interface [polypeptide binding]; other site 218491021259 active site 218491021260 MgATP binding site [chemical binding]; other site 218491021261 catalytic site [active] 218491021262 metal binding site [ion binding]; metal-binding site 218491021263 glycerol binding site [chemical binding]; other site 218491021264 homotetramer interface [polypeptide binding]; other site 218491021265 homodimer interface [polypeptide binding]; other site 218491021266 FBP binding site [chemical binding]; other site 218491021267 protein IIAGlc interface [polypeptide binding]; other site 218491021268 HMMPfam hit to PF00370, DE FGGY family of carbohydrate kinases, N-terminal domain, score 4.9e-133 218491021269 PS00933 FGGY family of carbohydrate kinases signature 1. 218491021270 PS00070 Aldehyde dehydrogenases cysteine active site. 218491021271 HMMPfam hit to PF02782, DE FGGY family of carbohydrate kinases, C-terminal domain, score 6.1e-101 218491021272 PS00445 FGGY family of carbohydrate kinases signature 2. 218491021273 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 218491021274 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 218491021275 putative active site [active] 218491021276 HMMPfam hit to PF03320, DE Bacterial fructose-1,6-bisphosphatase, glpX-encoded, score 5.4e-232 218491021277 ferredoxin-NADP reductase; Provisional; Region: PRK10926 218491021278 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 218491021279 FAD binding pocket [chemical binding]; other site 218491021280 FAD binding motif [chemical binding]; other site 218491021281 phosphate binding motif [ion binding]; other site 218491021282 beta-alpha-beta structure motif; other site 218491021283 NAD binding pocket [chemical binding]; other site 218491021284 HMMPfam hit to PF00970, DE Oxidoreductase FAD-binding domain, score 3e-05 218491021285 HMMPfam hit to PF00175, DE Oxidoreductase NAD-binding domain, score 1.4e-24 218491021286 Predicted membrane protein [Function unknown]; Region: COG3152 218491021287 4 probable transmembrane helices predicted for ECA4270 by TMHMM2.0 at aa 20-42, 46-63, 75-97 and 101-123 218491021288 Signal peptide predicted for ECA4271 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.873 between residues 24 and 25; signal peptide 218491021289 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 218491021290 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 218491021291 triosephosphate isomerase; Provisional; Region: PRK14567 218491021292 substrate binding site [chemical binding]; other site 218491021293 dimer interface [polypeptide binding]; other site 218491021294 catalytic triad [active] 218491021295 HMMPfam hit to PF00121, DE Triosephosphate isomerase, score 6.4e-155 218491021296 PS00171 Triosephosphate isomerase active site. 218491021297 agmatine deiminase; Provisional; Region: PRK13551 218491021298 agmatine deiminase; Region: agmatine_aguA; TIGR03380 218491021299 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 218491021300 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 218491021301 putative active site; other site 218491021302 catalytic triad [active] 218491021303 putative dimer interface [polypeptide binding]; other site 218491021304 HMMPfam hit to PF00795, DE Carbon-nitrogen hydrolase, score 2.1e-81 218491021305 repetitive region 218491021306 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 218491021307 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 218491021308 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 218491021309 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 218491021310 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 218491021311 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 218491021312 PAAR motif; Region: PAAR_motif; pfam05488 218491021313 RHS Repeat; Region: RHS_repeat; pfam05593 218491021314 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 218491021315 RHS Repeat; Region: RHS_repeat; pfam05593 218491021316 RHS Repeat; Region: RHS_repeat; pfam05593 218491021317 RHS Repeat; Region: RHS_repeat; pfam05593 218491021318 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 218491021319 RHS Repeat; Region: RHS_repeat; pfam05593 218491021320 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 218491021321 2 probable transmembrane helices predicted for ECA4278 by TMHMM2.0 at aa 48-70 and 77-99 218491021322 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491021323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491021324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491021325 sequence-specific DNA binding site [nucleotide binding]; other site 218491021326 salt bridge; other site 218491021327 HMMPfam hit to PF01381, DE Helix-turn-helix, score 5.9e-17 218491021328 Predicted helix-turn-helix motif with score 1607.000, SD 4.66 at aa 29-50, sequence LSQVRLAELLGVDPRVYNRWEK 218491021329 CHC2 zinc finger; Region: zf-CHC2; cl17510 218491021330 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491021331 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218491021332 active site 218491021333 metal binding site [ion binding]; metal-binding site 218491021334 interdomain interaction site; other site 218491021335 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 5.2e-23 218491021336 HMMPfam hit to PF01751, DE Toprim domain, score 5.8e-06 218491021337 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 218491021338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491021339 active site 218491021340 DNA binding site [nucleotide binding] 218491021341 Int/Topo IB signature motif; other site 218491021342 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 0.034 218491021343 HMMPfam hit to PF00589, DE Phage integrase family, score 1e-34 218491021344 Signal peptide predicted for ECA4284 by SignalP 2.0 HMM (Signal peptide probabilty 0.911) with cleavage site probability 0.468 between residues 25 and 26; signal peptide 218491021345 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021346 PS00369 PTS HPR component histidine phosphorylation site signature. 218491021347 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021348 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491021349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218491021350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491021351 sequence-specific DNA binding site [nucleotide binding]; other site 218491021352 salt bridge; other site 218491021353 HMMPfam hit to PF01381, DE Helix-turn-helix, score 5.9e-17 218491021354 Predicted helix-turn-helix motif with score 1607.000, SD 4.66 at aa 29-50, sequence LSQVRLAELLGVDPRVYNRWEK 218491021355 CHC2 zinc finger; Region: zf-CHC2; cl17510 218491021356 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218491021357 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218491021358 active site 218491021359 metal binding site [ion binding]; metal-binding site 218491021360 interdomain interaction site; other site 218491021361 HMMPfam hit to PF01807, DE CHC2 zinc finger, score 5.2e-23 218491021362 HMMPfam hit to PF01751, DE Toprim domain, score 5.8e-06 218491021363 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287 218491021364 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218491021365 active site 218491021366 DNA binding site [nucleotide binding] 218491021367 Int/Topo IB signature motif; other site 218491021368 HMMPfam hit to PF02899, DE Phage integrase, N-terminal SAM-like domain, score 0.034 218491021369 HMMPfam hit to PF00589, DE Phage integrase family, score 1e-34 218491021370 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 218491021371 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 218491021372 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218491021373 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491021374 Walker A/P-loop; other site 218491021375 ATP binding site [chemical binding]; other site 218491021376 Q-loop/lid; other site 218491021377 ABC transporter signature motif; other site 218491021378 Walker B; other site 218491021379 D-loop; other site 218491021380 H-loop/switch region; other site 218491021381 HMMPfam hit to PF00005, DE ABC transporter, score 1.2e-61 218491021382 PS00211 ABC transporters family signature. 218491021383 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021384 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491021385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021386 dimer interface [polypeptide binding]; other site 218491021387 conserved gate region; other site 218491021388 putative PBP binding loops; other site 218491021389 ABC-ATPase subunit interface; other site 218491021390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491021391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021392 ABC-ATPase subunit interface; other site 218491021393 12 probable transmembrane helices predicted for ECA4297 by TMHMM2.0 at aa 35-57, 95-117, 124-146, 156-175, 195-217, 249-271, 292-314, 354-376, 388-410, 415-437, 458-480 and 512-532 218491021394 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.1e-08 218491021395 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.00016 218491021396 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218491021397 TolR protein; Region: tolR; TIGR02801 218491021398 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02472, DE Biopolymer transport protein ExbD/TolR, score 5.9e-17 218491021399 1 probable transmembrane helix predicted for ECA4298 by TMHMM2.0 at aa 20-42 218491021400 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 218491021401 HMMPfam hit to PF01618, DE MotA/TolQ/ExbB proton channel family, score 2.3e-45 218491021402 3 probable transmembrane helices predicted for ECA4299 by TMHMM2.0 at aa 15-37, 120-142 and 167-189 218491021403 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 218491021404 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 218491021405 HMMPfam hit to PF03544, DE Gram-negative bacterial tonB protein, score 8.4e-06 218491021406 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 218491021407 Signal peptide predicted for ECA4301 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.964 between residues 26 and 27; signal peptide 218491021408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 218491021409 Signal peptide predicted for ECA4302 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.961 between residues 35 and 36; signal peptide 218491021410 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 218491021411 N-terminal plug; other site 218491021412 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 218491021413 ligand-binding site [chemical binding]; other site 218491021414 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021415 HMMPfam hit to PF00593, DE TonB dependent receptor, score 1.2e-06 218491021416 Signal peptide predicted for ECA4303 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.779 between residues 30 and 31; signal peptide 218491021417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218491021418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491021419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218491021420 dimerization interface [polypeptide binding]; other site 218491021421 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 5.1e-26 218491021422 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 218491021423 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 218491021424 active site 218491021425 ADP/pyrophosphate binding site [chemical binding]; other site 218491021426 dimerization interface [polypeptide binding]; other site 218491021427 allosteric effector site; other site 218491021428 fructose-1,6-bisphosphate binding site; other site 218491021429 HMMPfam hit to PF00365, DE Phosphofructokinase, score 1.9e-178 218491021430 PS00433 Phosphofructokinase signature. 218491021431 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 218491021432 Signal peptide predicted for ECA4308 by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.394 between residues 41 and 42; signal peptide 218491021433 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 218491021434 HMMPfam hit to PF01545, DE Cation efflux family, score 1e-97 218491021435 6 probable transmembrane helices predicted for ECA4308 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139, 158-175 and 180-199 218491021436 Signal peptide predicted for ECA4309 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.271 between residues 44 and 45; signal peptide 218491021437 putative arabinose transporter; Provisional; Region: PRK03545 218491021438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491021439 putative substrate translocation pore; other site 218491021440 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.00033 218491021441 12 probable transmembrane helices predicted for ECA4309 by TMHMM2.0 at aa 13-35, 48-70, 77-99, 103-125, 137-159, 164-186, 207-229, 244-263, 270-292, 302-324, 331-353 and 363-385 218491021442 Signal peptide predicted for ECA4310 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23; signal peptide 218491021443 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 218491021444 dimer interface [polypeptide binding]; other site 218491021445 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 218491021446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491021447 active site 218491021448 phosphorylation site [posttranslational modification] 218491021449 intermolecular recognition site; other site 218491021450 dimerization interface [polypeptide binding]; other site 218491021451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218491021452 DNA binding site [nucleotide binding] 218491021453 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 7.9e-41 218491021454 HMMPfam hit to PF00486, DE Transcriptional regulatory protein, C terminal, score 4.6e-27 218491021455 two-component sensor protein; Provisional; Region: cpxA; PRK09470 218491021456 Signal peptide predicted for ECA4312 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.312 between residues 26 and 27; signal peptide 218491021457 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 218491021458 dimerization interface [polypeptide binding]; other site 218491021459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 218491021460 dimer interface [polypeptide binding]; other site 218491021461 phosphorylation site [posttranslational modification] 218491021462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491021463 ATP binding site [chemical binding]; other site 218491021464 Mg2+ binding site [ion binding]; other site 218491021465 G-X-G motif; other site 218491021466 2 probable transmembrane helices predicted for ECA4312 by TMHMM2.0 at aa 5-27 and 165-187 218491021467 HMMPfam hit to PF00672, DE HAMP domain, score 4.5e-09 218491021468 HMMPfam hit to PF00512, DE His Kinase A (phosphoacceptor) domain, score 1.1e-14 218491021469 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 5.1e-34 218491021470 Signal peptide predicted for ECA4313 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.980 between residues 21 and 22; signal peptide 218491021471 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 218491021472 Signal peptide predicted for ECA4314 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.991 between residues 18 and 19; signal peptide 218491021473 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 218491021474 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 218491021475 HMMPfam hit to PF00588, DE SpoU rRNA Methylase family, score 7.7e-40 218491021476 Signal peptide predicted for ECA4316 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.414 between residues 26 and 27; signal peptide 218491021477 Predicted permeases [General function prediction only]; Region: COG0679 218491021478 10 probable transmembrane helices predicted for ECA4317 by TMHMM2.0 at aa 10-32, 45-62, 72-91, 104-126, 130-152, 172-194, 204-223, 236-258, 263-280 and 292-314 218491021479 HMMPfam hit to PF03547, DE Auxin Efflux Carrier, score 1.4e-11 218491021480 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 218491021481 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 218491021482 putative active site [active] 218491021483 catalytic site [active] 218491021484 putative metal binding site [ion binding]; other site 218491021485 HMMPfam hit to PF03009, DE Glycerophosphoryl diester phosphodiesterase family, score 8.1e-57 218491021486 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218491021487 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 218491021488 Walker A/P-loop; other site 218491021489 ATP binding site [chemical binding]; other site 218491021490 Q-loop/lid; other site 218491021491 ABC transporter signature motif; other site 218491021492 Walker B; other site 218491021493 D-loop; other site 218491021494 H-loop/switch region; other site 218491021495 TOBE domain; Region: TOBE_2; pfam08402 218491021496 HMMPfam hit to PF00005, DE ABC transporter, score 2.1e-61 218491021497 PS00211 ABC transporters family signature. 218491021498 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218491021500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021501 dimer interface [polypeptide binding]; other site 218491021502 conserved gate region; other site 218491021503 ABC-ATPase subunit interface; other site 218491021504 6 probable transmembrane helices predicted for ECA4320 by TMHMM2.0 at aa 12-34, 84-106, 113-132, 147-169, 190-212 and 253-275 218491021505 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 5e-14 218491021506 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491021507 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218491021508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021509 dimer interface [polypeptide binding]; other site 218491021510 conserved gate region; other site 218491021511 putative PBP binding loops; other site 218491021512 ABC-ATPase subunit interface; other site 218491021513 6 probable transmembrane helices predicted for ECA4321 by TMHMM2.0 at aa 12-34, 75-97, 110-130, 157-179, 206-228 and 266-288 218491021514 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.1e-17 218491021515 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491021516 Signal peptide predicted for ECA4322 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 30 and 31; signal peptide 218491021517 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 218491021518 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218491021519 HMMPfam hit to PF01547, DE Bacterial extracellular solute-binding protein, score 1.4e-72 218491021520 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 218491021521 Signal peptide predicted for ECA4323 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.375 between residues 16 and 17; signal peptide 218491021522 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218491021523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491021524 DNA-binding site [nucleotide binding]; DNA binding site 218491021525 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 218491021526 HMMPfam hit to PF00455, DE Bacterial regulatory proteins, deoR family, score 6.6e-65 218491021527 Predicted helix-turn-helix motif with score 1632.000, SD 4.75 at aa 20-41, sequence VSINELTERLGVSHMTVRRDVQ 218491021528 PS00894 Bacterial regulatory proteins, deoR family signature. 218491021529 1 probable transmembrane helix predicted for ECA4326 by TMHMM2.0 at aa 5-24 218491021530 Signal peptide predicted for ECA4327 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.252 between residues 22 and 23; signal peptide 218491021531 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 218491021532 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 218491021533 HMMPfam hit to PF03446, DE NAD binding domain of 6-phosphogluconate dehydrogenase, score 0.017 218491021534 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 218491021535 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 218491021537 putative aldolase; Validated; Region: PRK08130 218491021538 intersubunit interface [polypeptide binding]; other site 218491021539 active site 218491021540 Zn2+ binding site [ion binding]; other site 218491021541 HMMPfam hit to PF00596, DE Class II Aldolase and Adducin N-terminal domain, score 3.2e-61 218491021542 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 218491021543 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 218491021544 AP (apurinic/apyrimidinic) site pocket; other site 218491021545 DNA interaction; other site 218491021546 Metal-binding active site; metal-binding site 218491021547 putative transporter; Provisional; Region: PRK09821 218491021548 Signal peptide predicted for ECA4331 by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.536 between residues 42 and 43; signal peptide 218491021549 GntP family permease; Region: GntP_permease; pfam02447 218491021550 HMMPfam hit to PF02447, DE GntP family permease, score 4.2e-191 218491021551 12 probable transmembrane helices predicted for ECA4331 by TMHMM2.0 at aa 5-22, 26-48, 53-75, 103-125, 138-160, 175-197, 237-259, 269-291, 304-326, 341-360, 392-414 and 429-451 218491021552 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218491021553 Signal peptide predicted for ECA4332 by SignalP 2.0 HMM (Signal peptide probabilty 0.619) with cleavage site probability 0.265 between residues 27 and 28; signal peptide 218491021554 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491021555 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491021556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491021557 dimer interface [polypeptide binding]; other site 218491021558 putative CheW interface [polypeptide binding]; other site 218491021559 2 probable transmembrane helices predicted for ECA4332 by TMHMM2.0 at aa 10-32 and 196-218 218491021560 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 4.6e-93 218491021561 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491021562 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 218491021563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491021564 dimer interface [polypeptide binding]; other site 218491021565 putative CheW interface [polypeptide binding]; other site 218491021566 1 probable transmembrane helix predicted for ECA4333 by TMHMM2.0 at aa 13-35 218491021567 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 1.3e-93 218491021568 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491021569 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491021570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218491021571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491021572 dimer interface [polypeptide binding]; other site 218491021573 putative CheW interface [polypeptide binding]; other site 218491021574 2 probable transmembrane helices predicted for ECA4334 by TMHMM2.0 at aa 13-35 and 189-211 218491021575 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 2.7e-96 218491021576 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 218491021577 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 218491021578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491021579 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 218491021580 dimer interface [polypeptide binding]; other site 218491021581 putative CheW interface [polypeptide binding]; other site 218491021582 2 probable transmembrane helices predicted for ECA4335 by TMHMM2.0 at aa 10-32 and 186-208 218491021583 HMMPfam hit to PF00015, DE Methyl-accepting chemotaxis protein (MCP) signaling domain, score 4.1e-94 218491021584 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 218491021585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491021586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491021587 homodimer interface [polypeptide binding]; other site 218491021588 catalytic residue [active] 218491021589 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 2.4e-08 218491021590 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 218491021591 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 218491021592 Walker A/P-loop; other site 218491021593 ATP binding site [chemical binding]; other site 218491021594 Q-loop/lid; other site 218491021595 ABC transporter signature motif; other site 218491021596 Walker B; other site 218491021597 D-loop; other site 218491021598 H-loop/switch region; other site 218491021599 HMMPfam hit to PF00005, DE ABC transporter, score 2.9e-56 218491021600 PS00211 ABC transporters family signature. 218491021601 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021602 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 218491021603 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 218491021604 Walker A/P-loop; other site 218491021605 ATP binding site [chemical binding]; other site 218491021606 Q-loop/lid; other site 218491021607 ABC transporter signature motif; other site 218491021608 Walker B; other site 218491021609 D-loop; other site 218491021610 H-loop/switch region; other site 218491021611 HMMPfam hit to PF00005, DE ABC transporter, score 3.2e-63 218491021612 PS00211 ABC transporters family signature. 218491021613 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021614 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 218491021615 Signal peptide predicted for ECA4339 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.498 between residues 29 and 30; signal peptide 218491021616 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 218491021617 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 218491021618 TM-ABC transporter signature motif; other site 218491021619 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 1.2e-103 218491021620 11 probable transmembrane helices predicted for ECA4339 by TMHMM2.0 at aa 7-28, 43-65, 91-107, 111-133, 138-160, 164-186, 193-210, 261-283, 315-337, 352-374 and 386-405 218491021621 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 218491021622 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 218491021623 TM-ABC transporter signature motif; other site 218491021624 HMMPfam hit to PF02653, DE Branched-chain amino acid transport system / permease component, score 3e-97 218491021625 8 probable transmembrane helices predicted for ECA4340 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124, 153-175, 207-229, 244-266 and 282-301 218491021626 Signal peptide predicted for ECA4341 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 24 and 25; signal peptide 218491021627 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 218491021628 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 218491021629 dimerization interface [polypeptide binding]; other site 218491021630 ligand binding site [chemical binding]; other site 218491021631 HMMPfam hit to PF01094, DE Receptor family ligand binding region, score 1.3e-54 218491021632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218491021633 Coenzyme A binding pocket [chemical binding]; other site 218491021634 HMMPfam hit to PF00583, DE Acetyltransferase (GNAT) family, score 2.8e-06 218491021635 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 218491021636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218491021637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218491021638 DNA binding residues [nucleotide binding] 218491021639 HMMPfam hit to PF00140, DE Sigma-70 factor, region 1.2, score 8.4e-99 218491021640 PS00716 Sigma-70 factors family signature 2. 218491021641 Predicted helix-turn-helix motif with score 2068.000, SD 6.23 at aa 252-273, sequence STLQELADQYGVSAERVRQLEK 218491021642 PS00715 Sigma-70 factors family signature 1. 218491021643 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 218491021644 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 218491021645 HMMPfam hit to PF02687, DE Predicted permease, score 9.3e-17 218491021646 4 probable transmembrane helices predicted for ECA4344 by TMHMM2.0 at aa 42-64, 194-216, 237-259 and 294-313 218491021647 cell division protein FtsE; Provisional; Region: PRK10908 218491021648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491021649 Walker A/P-loop; other site 218491021650 ATP binding site [chemical binding]; other site 218491021651 Q-loop/lid; other site 218491021652 ABC transporter signature motif; other site 218491021653 Walker B; other site 218491021654 D-loop; other site 218491021655 H-loop/switch region; other site 218491021656 HMMPfam hit to PF00005, DE ABC transporter, score 3.5e-70 218491021657 PS00211 ABC transporters family signature. 218491021658 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021659 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 218491021660 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 218491021661 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218491021662 P loop; other site 218491021663 GTP binding site [chemical binding]; other site 218491021664 HMMPfam hit to PF00448, DE SRP54-type protein, GTPase domain, score 4.2e-122 218491021665 PS00300 SRP54-type proteins GTP-binding domain signature. 218491021666 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021667 HMMPfam hit to PF02881, DE SRP54-type protein, helical bundle domain, score 6.9e-17 218491021668 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 218491021669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491021670 S-adenosylmethionine binding site [chemical binding]; other site 218491021671 HMMPfam hit to PF03602, DE Conserved hypothetical protein 95, score 7.2e-92 218491021672 PS00092 N-6 Adenine-specific DNA methylases signature. 218491021673 hypothetical protein; Provisional; Region: PRK10910 218491021674 2 probable transmembrane helices predicted for ECA4348 by TMHMM2.0 at aa 4-23 and 30-52 218491021675 Signal peptide predicted for ECA4349 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.960 between residues 19 and 20; signal peptide 218491021676 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 218491021677 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 218491021678 Predicted membrane protein [Function unknown]; Region: COG3714 218491021679 7 probable transmembrane helices predicted for ECA4351 by TMHMM2.0 at aa 2-21, 41-63, 76-98, 102-124, 131-148, 158-180 and 187-204 218491021680 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 218491021681 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218491021682 metal-binding site [ion binding] 218491021683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218491021684 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491021685 HMMPfam hit to PF00403, DE Heavy-metal-associated domain, score 2.1e-13 218491021686 PS01047 Heavy-metal-associated domain. 218491021687 6 probable transmembrane helices predicted for ECA4352 by TMHMM2.0 at aa 178-197, 204-226, 241-263, 400-422, 437-459 and 744-766 218491021688 HMMPfam hit to PF00122, DE E1-E2 ATPase, score 3.7e-91 218491021689 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 2.9e-30 218491021690 PS00154 E1-E2 ATPases phosphorylation site. 218491021691 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021692 PS01229 Hypothetical cof family signature 2. 218491021693 PS00141 Eukaryotic and viral aspartyl proteases active site. 218491021694 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 218491021695 CPxP motif; other site 218491021696 HMMPfam hit to PF01206, DE Uncharacterized protein family UPF0033, score 1.8e-34 218491021697 PS01148 Uncharacterized protein family UPF0033 signature. 218491021698 hypothetical protein; Provisional; Region: PRK11212 218491021699 HMMPfam hit to PF02592, DE Uncharacterized ACR, YhhQ family COG1738, score 1.1e-70 218491021700 6 probable transmembrane helices predicted for ECA4354 by TMHMM2.0 at aa 13-32, 42-64, 71-93, 108-130, 142-164 and 184-206 218491021701 Signal peptide predicted for ECA4355 by SignalP 2.0 HMM (Signal peptide probabilty 0.860) with cleavage site probability 0.595 between residues 32 and 33; signal peptide 218491021702 hypothetical protein; Provisional; Region: PRK11615 218491021703 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021704 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 218491021705 Signal peptide predicted for ECA4357 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.750 between residues 19 and 20; signal peptide 218491021706 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218491021707 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021708 major facilitator superfamily transporter; Provisional; Region: PRK05122 218491021709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491021710 putative substrate translocation pore; other site 218491021711 12 probable transmembrane helices predicted for ECA4358 by TMHMM2.0 at aa 20-42, 52-74, 86-108, 123-145, 152-174, 178-200, 221-243, 253-272, 279-301, 311-333, 340-362 and 367-389 218491021712 inner membrane protein YhjD; Region: TIGR00766 218491021713 Signal peptide predicted for ECA4359 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.882 between residues 33 and 34; signal peptide 218491021714 HMMPfam hit to PF03631, DE Ribonuclease BN-like family, score 3.4e-25 218491021715 6 probable transmembrane helices predicted for ECA4359 by TMHMM2.0 at aa 12-34, 70-92, 122-144, 164-186, 198-220 and 235-257 218491021716 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218491021717 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218491021718 substrate binding site [chemical binding]; other site 218491021719 ATP binding site [chemical binding]; other site 218491021720 HMMPfam hit to PF00294, DE pfkB family carbohydrate kinase, score 1.5e-78 218491021721 PS00584 pfkB family of carbohydrate kinases signature 2. 218491021722 Predicted helix-turn-helix motif with score 1083.000, SD 2.88 at aa 279-300, sequence GSTQEAAQRGHLTASTVIQYRG 218491021723 Signal peptide predicted for ECA4361 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25; signal peptide 218491021724 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 218491021725 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218491021726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218491021727 HMMPfam hit to PF00675, DE Insulinase (Peptidase family M16), score 0.016 218491021728 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 218491021729 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218491021730 HMMPfam hit to PF00375, DE Sodium:dicarboxylate symporter family, score 2.4e-205 218491021731 9 probable transmembrane helices predicted for ECA4362 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 142-164, 184-206, 219-241, 289-311, 326-348 and 353-375 218491021732 PS00714 Sodium:dicarboxylate symporter family signature 2. 218491021733 PS00713 Sodium:dicarboxylate symporter family signature 1. 218491021734 Signal peptide predicted for ECA4363 by SignalP 2.0 HMM (Signal peptide probabilty 0.636) with cleavage site probability 0.472 between residues 37 and 38; signal peptide 218491021735 putative diguanylate cyclase; Provisional; Region: PRK13561 218491021736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 218491021737 metal binding site [ion binding]; metal-binding site 218491021738 active site 218491021739 I-site; other site 218491021740 HMMPfam hit to PF00990, DE GGDEF domain, score 0.04 218491021741 HMMPfam hit to PF00672, DE HAMP domain, score 0.0046 218491021742 2 probable transmembrane helices predicted for ECA4363 by TMHMM2.0 at aa 13-35 and 156-178 218491021743 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 218491021744 5 probable transmembrane helices predicted for ECA4364 by TMHMM2.0 at aa 20-39, 44-63, 70-92, 112-131 and 138-160 218491021745 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 218491021746 1 probable transmembrane helix predicted for ECA4365 by TMHMM2.0 at aa 7-29 218491021747 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 218491021748 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 218491021749 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 218491021750 YhjQ protein; Region: YhjQ; pfam06564 218491021751 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218491021752 Pseudogene. This CDS appears to have a frameshift mutation around codon 140. The frameshift occurs within a polymeric tract of (C)8. Similar to Escherichia coli cellulose synthase catalytic subunit [UDP-forming] BcsA or b3533 SWALL:BCSA_ECOLI (SWALL:P37653) (872 aa) fasta scores: E(): 0, 68.33% id in 878 aa;cellulose synthase catalytic subunit [UDP-forming] (pseudogene) 218491021753 1 probable transmembrane helix predicted for ECA4370 by TMHMM2.0 at aa 29-48 218491021754 Signal peptide predicted for ECA4371 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.379 between residues 16 and 17 218491021755 7 probable transmembrane helices predicted for ECA4371 by TMHMM2.0 at aa 5-27, 42-64, 77-99, 393-415, 487-506, 516-538 and 681-700 218491021756 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021757 HMMPfam hit to PF00535, DE Glycosyl transferase, score 6.1e-22 218491021758 cellulose synthase regulator protein; Provisional; Region: PRK11114 218491021759 Signal peptide predicted for ECA4372 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.528 between residues 21 and 22; signal peptide 218491021760 HMMPfam hit to PF03170, DE Bacterial cellulose synthase subunit, score 8.3e-188 218491021761 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021762 1 probable transmembrane helix predicted for ECA4372 by TMHMM2.0 at aa 728-747 218491021763 Signal peptide predicted for ECA4373 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.963 between residues 22 and 23; signal peptide 218491021764 endo-1,4-D-glucanase; Provisional; Region: PRK11097 218491021765 HMMPfam hit to PF01270, DE Glycosyl hydrolases family 8, score 2.6e-96 218491021766 HMMPfam hit to PF00515, DE TPR Domain, score 0.11 218491021767 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 218491021768 Protein of unknown function (DUF1308); Region: DUF1308; pfam07000 218491021769 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 218491021770 HMMPfam hit to PF00515, DE TPR Domain, score 0.33 218491021771 HMMPfam hit to PF00515, DE TPR Domain, score 0.059 218491021772 HMMPfam hit to PF00515, DE TPR Domain, score 11 218491021773 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 218491021774 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218491021775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218491021776 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 1.9e-11 218491021777 HMMPfam hit to PF00165, DE Bacterial regulatory helix-turn-helix proteins, araC family, score 0.29 218491021778 Predicted helix-turn-helix motif with score 1529.000, SD 4.39 at aa 263-284, sequence PTLEEVADKVGLSSWSLQRRLR 218491021779 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 218491021780 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 218491021781 active site 218491021782 substrate binding site [chemical binding]; other site 218491021783 ATP binding site [chemical binding]; other site 218491021784 PS00109 Tyrosine protein kinases specific active-site signature. 218491021785 ethanolamine permease; Region: 2A0305; TIGR00908 218491021786 HMMPfam hit to PF00324, DE Amino acid permease, score 2.2e-08 218491021787 12 probable transmembrane helices predicted for ECA4377 by TMHMM2.0 at aa 83-102, 112-134, 160-182, 197-214, 221-243, 258-280, 301-323, 350-372, 402-424, 428-450, 466-488 and 492-509 218491021788 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 218491021789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218491021790 inhibitor-cofactor binding pocket; inhibition site 218491021791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491021792 catalytic residue [active] 218491021793 HMMPfam hit to PF00202, DE Aminotransferase class-III, score 3.4e-83 218491021794 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218491021795 Signal peptide predicted for ECA4379 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 28 and 29; signal peptide 218491021796 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 218491021797 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 218491021798 HMMPfam hit to PF01019, DE Gamma-glutamyltranspeptidase, score 1.6e-222 218491021799 PS00462 Gamma-glutamyltranspeptidase signature. 218491021800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491021801 D-galactonate transporter; Region: 2A0114; TIGR00893 218491021802 putative substrate translocation pore; other site 218491021803 11 probable transmembrane helices predicted for ECA4380 by TMHMM2.0 at aa 35-52, 68-89, 104-126, 165-187, 191-213, 254-276, 291-313, 326-348, 358-380, 393-412 and 417-439 218491021804 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0012 218491021805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491021806 DNA-binding site [nucleotide binding]; DNA binding site 218491021807 Transcriptional regulators [Transcription]; Region: GntR; COG1802 218491021808 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 218491021809 Predicted helix-turn-helix motif with score 1810.000, SD 5.35 at aa 29-50, sequence PSQNALAEMYNISRTTVRHILA 218491021810 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218491021811 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 218491021812 putative NAD(P) binding site [chemical binding]; other site 218491021813 catalytic Zn binding site [ion binding]; other site 218491021814 structural Zn binding site [ion binding]; other site 218491021815 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00107, DE Zinc-binding dehydrogenase, score 2.4e-87 218491021816 PS00059 Zinc-containing alcohol dehydrogenases signature. 218491021817 altronate oxidoreductase; Provisional; Region: PRK03643 218491021818 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 218491021819 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 218491021820 HMMPfam hit to PF01232, DE Mannitol dehydrogenase, score 2.6e-135 218491021821 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 218491021822 EamA-like transporter family; Region: EamA; pfam00892 218491021823 10 probable transmembrane helices predicted for ECA4384 by TMHMM2.0 at aa 7-26, 31-53, 60-82, 86-108, 115-137, 142-164, 177-199, 214-236, 249-266 and 270-292 218491021824 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 2.3e-15 218491021825 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 1.3e-10 218491021826 Signal peptide predicted for ECA4385 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.948 between residues 23 and 24; signal peptide 218491021827 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 218491021828 active site 218491021829 catalytic residues [active] 218491021830 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 218491021831 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491021832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491021833 homodimer interface [polypeptide binding]; other site 218491021834 catalytic residue [active] 218491021835 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218491021836 beta-galactosidase; Region: BGL; TIGR03356 218491021837 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 9e-136 218491021838 PS00572 Glycosyl hydrolases family 1 active site. 218491021839 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491021840 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 218491021841 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218491021842 active site turn [active] 218491021843 phosphorylation site [posttranslational modification] 218491021844 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 218491021845 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218491021846 HPr interaction site; other site 218491021847 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218491021848 active site 218491021849 phosphorylation site [posttranslational modification] 218491021850 HMMPfam hit to PF00358, DE phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 3.1e-57 218491021851 PS00371 PTS EIIA domains phosphorylation site signature 1. 218491021852 9 probable transmembrane helices predicted for ECA4388 by TMHMM2.0 at aa 112-134, 149-168, 175-197, 207-229, 249-271, 286-308, 358-380, 390-412 and 425-447 218491021853 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 5.1e-23 218491021854 HMMPfam hit to PF00367, DE phosphotransferase system, EIIB, score 9.4e-16 218491021855 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218491021856 transcriptional antiterminator BglG; Provisional; Region: PRK09772 218491021857 CAT RNA binding domain; Region: CAT_RBD; smart01061 218491021858 PRD domain; Region: PRD; pfam00874 218491021859 PRD domain; Region: PRD; pfam00874 218491021860 HMMPfam hit to PF00874, DE PRD domain, score 2.2e-07 218491021861 HMMPfam hit to PF00874, DE PRD domain, score 5.9e-30 218491021862 HMMPfam hit to PF03123, DE CAT RNA binding domain, score 3.7e-18 218491021863 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 218491021864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491021865 Walker A/P-loop; other site 218491021866 ATP binding site [chemical binding]; other site 218491021867 Q-loop/lid; other site 218491021868 ABC transporter signature motif; other site 218491021869 Walker B; other site 218491021870 D-loop; other site 218491021871 H-loop/switch region; other site 218491021872 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 218491021873 HMMPfam hit to PF00005, DE ABC transporter, score 5.8e-62 218491021874 PS00211 ABC transporters family signature. 218491021875 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021876 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 218491021877 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491021878 Walker A/P-loop; other site 218491021879 ATP binding site [chemical binding]; other site 218491021880 Q-loop/lid; other site 218491021881 ABC transporter signature motif; other site 218491021882 Walker B; other site 218491021883 D-loop; other site 218491021884 H-loop/switch region; other site 218491021885 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491021886 HMMPfam hit to PF00005, DE ABC transporter, score 5.7e-58 218491021887 PS00211 ABC transporters family signature. 218491021888 PS00017 ATP/GTP-binding site motif A (P-loop). 218491021889 dipeptide transporter; Provisional; Region: PRK10913 218491021890 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218491021891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021892 dimer interface [polypeptide binding]; other site 218491021893 conserved gate region; other site 218491021894 putative PBP binding loops; other site 218491021895 ABC-ATPase subunit interface; other site 218491021896 4 probable transmembrane helices predicted for ECA4392 by TMHMM2.0 at aa 58-80, 130-152, 167-189 and 291-313 218491021897 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 5.9e-06 218491021898 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491021899 Signal peptide predicted for ECA4393 by SignalP 2.0 HMM (Signal peptide probabilty 0.621) with cleavage site probability 0.270 between residues 28 and 29; signal peptide 218491021900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021901 dimer interface [polypeptide binding]; other site 218491021902 conserved gate region; other site 218491021903 putative PBP binding loops; other site 218491021904 ABC-ATPase subunit interface; other site 218491021905 6 probable transmembrane helices predicted for ECA4393 by TMHMM2.0 at aa 7-29, 98-120, 133-155, 198-220, 258-280 and 308-330 218491021906 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.3e-07 218491021907 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491021908 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491021909 Signal peptide predicted for ECA4394 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 28 and 29; signal peptide 218491021910 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 218491021911 peptide binding site [polypeptide binding]; other site 218491021912 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 2.8e-241 218491021913 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 218491021914 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 218491021915 HMMPfam hit to PF03390, DE Bacterial sodium:citrate symporter, score 4.7e-191 218491021916 12 probable transmembrane helices predicted for ECA4395 by TMHMM2.0 at aa 56-75, 85-107, 112-131, 146-163, 176-195, 205-227, 240-262, 297-319, 326-348, 363-385, 387-409 and 448-470 218491021917 Signal peptide predicted for ECA4396 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.842 between residues 33 and 34; signal peptide 218491021918 2 probable transmembrane helices predicted for ECA4396 by TMHMM2.0 at aa 13-35 and 68-87 218491021919 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 218491021920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218491021921 active site 218491021922 phosphorylation site [posttranslational modification] 218491021923 intermolecular recognition site; other site 218491021924 dimerization interface [polypeptide binding]; other site 218491021925 Predicted helix-turn-helix motif with score 1115.000, SD 2.98 at aa 180-201, sequence FSTEMLANAIGISRVSCRKYLI 218491021926 HMMPfam hit to PF00072, DE Response regulator receiver domain, score 2.2e-27 218491021927 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021928 sensory histidine kinase DcuS; Provisional; Region: PRK11086 218491021929 PAS domain; Region: PAS; smart00091 218491021930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 218491021931 putative active site [active] 218491021932 heme pocket [chemical binding]; other site 218491021933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491021934 ATP binding site [chemical binding]; other site 218491021935 Mg2+ binding site [ion binding]; other site 218491021936 G-X-G motif; other site 218491021937 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 2.8e-28 218491021938 2 probable transmembrane helices predicted for ECA4399 by TMHMM2.0 at aa 20-42 and 184-206 218491021939 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218491021940 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218491021941 transmembrane helices; other site 218491021942 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00939, DE Sodium:sulfate symporter transmembrane region, score 3.3e-181 218491021943 12 probable transmembrane helices predicted for ECA4400 by TMHMM2.0 at aa 7-24, 34-53, 55-74, 84-101, 108-130, 218-240, 269-288, 292-311, 324-346, 356-378, 390-412 and 438-460 218491021944 putative transporter; Validated; Region: PRK03818 218491021945 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 218491021946 TrkA-C domain; Region: TrkA_C; pfam02080 218491021947 TrkA-C domain; Region: TrkA_C; pfam02080 218491021948 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 218491021949 11 probable transmembrane helices predicted for ECA4401 by TMHMM2.0 at aa 4-21, 26-48, 61-83, 90-112, 160-182, 371-393, 397-419, 431-448, 463-485, 492-513 and 528-550 218491021950 HMMPfam hit to PF02080, DE TrkA-C domain, score 1.1e-11 218491021951 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 218491021952 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 218491021953 putative dimer interface [polypeptide binding]; other site 218491021954 HMMPfam hit to PF00011, DE Hsp20/alpha crystallin family, score 1.3e-15 218491021955 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 218491021956 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 218491021957 putative dimer interface [polypeptide binding]; other site 218491021958 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00011, DE Hsp20/alpha crystallin family, score 1.7e-23 218491021959 Signal peptide predicted for ECA4404 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.516 between residues 29 and 30; signal peptide 218491021960 hypothetical protein; Provisional; Region: PRK11616 218491021961 2 probable transmembrane helices predicted for ECA4404 by TMHMM2.0 at aa 7-29 and 56-78 218491021962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491021963 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 218491021964 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 218491021965 Signal peptide predicted for ECA4406 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.972 between residues 22 and 23; signal peptide 218491021966 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 218491021967 beta-galactosidase; Region: BGL; TIGR03356 218491021968 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 4.1e-130 218491021969 PS00572 Glycosyl hydrolases family 1 active site. 218491021970 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 218491021971 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 218491021972 10 probable transmembrane helices predicted for ECA4408 by TMHMM2.0 at aa 35-57, 82-104, 111-129, 139-161, 181-203, 213-235, 240-262, 289-311, 332-354 and 392-414 218491021973 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 0.1 218491021974 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 218491021975 active site 218491021976 P-loop; other site 218491021977 phosphorylation site [posttranslational modification] 218491021978 HMMPfam hit to PF02302, DE PTS system, Lactose/Cellobiose specific IIB subunit, score 2.1e-32 218491021979 Signal peptide predicted for ECA4410 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 47 and 48; signal peptide 218491021980 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 218491021981 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491021982 substrate binding pocket [chemical binding]; other site 218491021983 membrane-bound complex binding site; other site 218491021984 hinge residues; other site 218491021985 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 218491021986 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 218491021987 active site 218491021988 dimer interface [polypeptide binding]; other site 218491021989 non-prolyl cis peptide bond; other site 218491021990 insertion regions; other site 218491021991 HMMPfam hit to PF00296, DE Luciferase-like monooxygenase, score 0.0029 218491021992 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218491021993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491021994 dimer interface [polypeptide binding]; other site 218491021995 conserved gate region; other site 218491021996 putative PBP binding loops; other site 218491021997 ABC-ATPase subunit interface; other site 218491021998 7 probable transmembrane helices predicted for ECA4412 by TMHMM2.0 at aa 12-34, 64-86, 106-123, 128-150, 163-185, 189-211 and 223-245 218491021999 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.4e-08 218491022000 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 218491022001 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 218491022002 Walker A/P-loop; other site 218491022003 ATP binding site [chemical binding]; other site 218491022004 Q-loop/lid; other site 218491022005 ABC transporter signature motif; other site 218491022006 Walker B; other site 218491022007 D-loop; other site 218491022008 H-loop/switch region; other site 218491022009 HMMPfam hit to PF00005, DE ABC transporter, score 9.7e-56 218491022010 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022011 PS00211 ABC transporters family signature. 218491022012 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 218491022013 Signal peptide predicted for ECA4414 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 22 and 23; signal peptide 218491022014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491022015 D-galactonate transporter; Region: 2A0114; TIGR00893 218491022016 putative substrate translocation pore; other site 218491022017 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0002 218491022018 10 probable transmembrane helices predicted for ECA4415 by TMHMM2.0 at aa 13-32, 52-74, 81-103, 168-190, 241-262, 277-299, 311-333, 338-360, 373-395 and 400-422 218491022019 galactonate dehydratase; Provisional; Region: PRK14017 218491022020 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 218491022021 putative active site pocket [active] 218491022022 putative metal binding site [ion binding]; other site 218491022023 HMMPfam hit to PF01188, DE Mandelate racemase / muconate lactonizing enzyme, C-terminal domain, score 5e-102 218491022024 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022025 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 218491022026 HMMPfam hit to PF02746, DE Mandelate racemase / muconate lactonizing enzyme, N-terminal domain, score 9.3e-51 218491022027 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 218491022028 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 218491022029 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 218491022030 active site 218491022031 intersubunit interface [polypeptide binding]; other site 218491022032 catalytic residue [active] 218491022033 HMMPfam hit to PF01081, DE KDPG and KHG aldolase, score 2e-12 218491022034 PS00606 Beta-ketoacyl synthases active site. 218491022035 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 218491022036 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 218491022037 Transcriptional regulators [Transcription]; Region: FadR; COG2186 218491022038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218491022039 DNA-binding site [nucleotide binding]; DNA binding site 218491022040 FCD domain; Region: FCD; pfam07729 218491022041 HMMPfam hit to PF00392, DE Bacterial regulatory proteins, gntR family, score 9e-14 218491022042 PS00043 Bacterial regulatory proteins, gntR family signature. 218491022043 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218491022044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491022045 Walker A/P-loop; other site 218491022046 ATP binding site [chemical binding]; other site 218491022047 Q-loop/lid; other site 218491022048 ABC transporter signature motif; other site 218491022049 Walker B; other site 218491022050 D-loop; other site 218491022051 H-loop/switch region; other site 218491022052 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491022053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218491022054 Walker A/P-loop; other site 218491022055 ATP binding site [chemical binding]; other site 218491022056 Q-loop/lid; other site 218491022057 ABC transporter signature motif; other site 218491022058 Walker B; other site 218491022059 D-loop; other site 218491022060 H-loop/switch region; other site 218491022061 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218491022062 HMMPfam hit to PF00005, DE ABC transporter, score 3.2e-58 218491022063 PS00211 ABC transporters family signature. 218491022064 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022065 HMMPfam hit to PF00005, DE ABC transporter, score 7.1e-65 218491022066 PS00211 ABC transporters family signature. 218491022067 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022068 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 218491022069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022070 dimer interface [polypeptide binding]; other site 218491022071 conserved gate region; other site 218491022072 putative PBP binding loops; other site 218491022073 ABC-ATPase subunit interface; other site 218491022074 6 probable transmembrane helices predicted for ECA4421 by TMHMM2.0 at aa 31-53, 103-125, 145-162, 167-189, 210-232 and 269-291 218491022075 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1.9e-10 218491022076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218491022077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022078 dimer interface [polypeptide binding]; other site 218491022079 conserved gate region; other site 218491022080 putative PBP binding loops; other site 218491022081 ABC-ATPase subunit interface; other site 218491022082 6 probable transmembrane helices predicted for ECA4422 by TMHMM2.0 at aa 13-30, 99-121, 134-156, 184-206, 246-268 and 288-310 218491022083 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 0.00036 218491022084 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 218491022085 active site 218491022086 tetramer interface [polypeptide binding]; other site 218491022087 HMMPfam hit to PF01156, DE Inosine-uridine preferring nucleoside hydrolase, score 1.5e-80 218491022088 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022089 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 218491022090 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 218491022091 active site 218491022092 tetramer interface [polypeptide binding]; other site 218491022093 HMMPfam hit to PF01156, DE Inosine-uridine preferring nucleoside hydrolase, score 1.2e-104 218491022094 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 218491022095 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 218491022096 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 218491022097 inhibitor site; inhibition site 218491022098 active site 218491022099 dimer interface [polypeptide binding]; other site 218491022100 catalytic residue [active] 218491022101 HMMPfam hit to PF00701, DE Dihydrodipicolinate synthetase family, score 4.4e-49 218491022102 PS00665 Dihydrodipicolinate synthetase signature 1. 218491022103 Signal peptide predicted for ECA4426 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.976 between residues 22 and 23; signal peptide 218491022104 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 218491022105 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 218491022106 HMMPfam hit to PF00496, DE Bacterial extracellular solute-binding proteins, family 5, score 2.8e-75 218491022107 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 218491022108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491022109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218491022110 dimerization interface [polypeptide binding]; other site 218491022111 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 2.1e-17 218491022112 Predicted helix-turn-helix motif with score 1727.000, SD 5.07 at aa 26-47, sequence GGITAAANMMFITQPAVSRLIK 218491022113 PS00044 Bacterial regulatory proteins, lysR family signature. 218491022114 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 6.3e-26 218491022115 sugar phosphate phosphatase; Provisional; Region: PRK10513 218491022116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491022117 active site 218491022118 motif I; other site 218491022119 motif II; other site 218491022120 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 218491022121 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 1.4e-07 218491022122 PS01229 Hypothetical cof family signature 2. 218491022123 PS01228 Hypothetical cof family signature 1. 218491022124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 218491022125 PS00589 PTS HPR component serine phosphorylation site signature. 218491022126 Signal peptide predicted for ECA4430 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.733 between residues 19 and 20; signal peptide 218491022127 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 218491022128 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022129 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 218491022130 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218491022131 beta-galactosidase; Region: BGL; TIGR03356 218491022132 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00232, DE Glycosyl hydrolase family 1, score 2.8e-135 218491022133 PS00572 Glycosyl hydrolases family 1 active site. 218491022134 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218491022135 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218491022136 active site 218491022137 methionine cluster; other site 218491022138 phosphorylation site [posttranslational modification] 218491022139 metal binding site [ion binding]; metal-binding site 218491022140 HMMPfam hit to PF02255, DE PTS system, Lactose/Cellobiose specific IIA subunit, score 1.9e-35 218491022141 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 218491022142 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 218491022143 10 probable transmembrane helices predicted for ECA4434 by TMHMM2.0 at aa 35-57, 82-104, 111-128, 138-160, 181-203, 213-235, 240-262, 284-306, 332-354 and 395-414 218491022144 HMMPfam hit to PF02378, DE Phosphotransferase system, EIIC, score 0.24 218491022145 Signal peptide predicted for ECA4435 by SignalP 2.0 HMM (Signal peptide probabilty 0.960) with cleavage site probability 0.764 between residues 20 and 21; signal peptide 218491022146 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 218491022147 active site 218491022148 P-loop; other site 218491022149 phosphorylation site [posttranslational modification] 218491022150 HMMPfam hit to PF02302, DE PTS system, Lactose/Cellobiose specific IIB subunit, score 1.4e-39 218491022151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218491022152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218491022153 DNA binding site [nucleotide binding] 218491022154 domain linker motif; other site 218491022155 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 218491022156 dimerization interface (closed form) [polypeptide binding]; other site 218491022157 ligand binding site [chemical binding]; other site 218491022158 HMMPfam hit to PF00356, DE Bacterial regulatory proteins, lacI family, score 5.3e-10 218491022159 Predicted helix-turn-helix motif with score 1702.000, SD 4.98 at aa 2-23, sequence ATMLDVAKKAGVSKATVSRVLT 218491022160 PS00356 Bacterial regulatory proteins, lacI family signature. 218491022161 HMMPfam hit to PF00532, DE Periplasmic binding proteins and sugar binding domain of the LacI family, score 3.9e-12 218491022162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491022163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218491022164 putative substrate translocation pore; other site 218491022165 HMMPfam hit to PF00083, DE Sugar (and other) transporter, score 0.0092 218491022166 12 probable transmembrane helices predicted for ECA4437 by TMHMM2.0 at aa 12-34, 39-56, 69-91, 95-112, 133-155, 160-179, 203-225, 245-267, 274-296, 300-317, 337-359 and 365-384 218491022167 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022168 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 218491022169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218491022170 Mg2+ binding site [ion binding]; other site 218491022171 G-X-G motif; other site 218491022172 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218491022173 anchoring element; other site 218491022174 dimer interface [polypeptide binding]; other site 218491022175 ATP binding site [chemical binding]; other site 218491022176 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 218491022177 active site 218491022178 putative metal-binding site [ion binding]; other site 218491022179 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218491022180 HMMPfam hit to PF00986, DE DNA gyrase B subunit, carboxyl terminus, score 1.5e-45 218491022181 HMMPfam hit to PF01751, DE Toprim domain, score 0.00033 218491022182 PS00177 DNA topoisomerase II signature. 218491022183 HMMPfam hit to PF00204, DE DNA gyrase B, score 5.5e-92 218491022184 HMMPfam hit to PF02518, DE Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, score 1.9e-32 218491022185 recF protein; Region: recf; TIGR00611 218491022186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491022187 Walker A/P-loop; other site 218491022188 ATP binding site [chemical binding]; other site 218491022189 Q-loop/lid; other site 218491022190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218491022191 ABC transporter signature motif; other site 218491022192 Walker B; other site 218491022193 D-loop; other site 218491022194 H-loop/switch region; other site 218491022195 HMMPfam hit to PF02463, DE RecF/RecN/SMC N terminal domain, score 2.9e-134 218491022196 PS00618 RecF protein signature 2. 218491022197 PS00617 RecF protein signature 1. 218491022198 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022199 DNA polymerase III subunit beta; Validated; Region: PRK05643 218491022200 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 218491022201 putative DNA binding surface [nucleotide binding]; other site 218491022202 dimer interface [polypeptide binding]; other site 218491022203 beta-clamp/clamp loader binding surface; other site 218491022204 beta-clamp/translesion DNA polymerase binding surface; other site 218491022205 HMMPfam hit to PF02768, DE DNA polymerase III beta subunit, C-terminal domain, score 4.4e-58 218491022206 HMMPfam hit to PF02767, DE DNA polymerase III beta subunit, central domain, score 8.6e-63 218491022207 HMMPfam hit to PF00712, DE DNA polymerase III beta subunit, N-terminal domain, score 6.5e-64 218491022208 DnaA N-terminal domain; Region: DnaA_N; pfam11638 218491022209 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 218491022210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218491022211 Walker A motif; other site 218491022212 ATP binding site [chemical binding]; other site 218491022213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 218491022214 Walker B motif; other site 218491022215 arginine finger; other site 218491022216 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 218491022217 DnaA box-binding interface [nucleotide binding]; other site 218491022218 HMMPfam hit to PF00308, DE Bacterial dnaA protein, score 2e-218 218491022219 PS01008 DnaA protein signature. 218491022220 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022221 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 218491022222 HMMPfam hit to PF00468, DE Ribosomal protein L34, score 5.1e-21 218491022223 PS00784 Ribosomal protein L34 signature. 218491022224 ribonuclease P; Reviewed; Region: rnpA; PRK01732 218491022225 HMMPfam hit to PF00825, DE Ribonuclease P, score 5.5e-57 218491022226 PS00648 Bacterial ribonuclease P protein component signature. 218491022227 membrane protein insertase; Provisional; Region: PRK01318 218491022228 Signal peptide predicted for ECA4445 by SignalP 2.0 HMM (Signal peptide probabilty 0.957) with cleavage site probability 0.865 between residues 21 and 22; signal peptide 218491022229 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 218491022230 5 probable transmembrane helices predicted for ECA4445 by TMHMM2.0 at aa 7-24, 348-370, 416-438, 458-475 and 495-517 218491022231 HMMPfam hit to PF02096, DE 60Kd inner membrane protein, score 7.4e-118 218491022232 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 218491022233 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 218491022234 trmE is a tRNA modification GTPase; Region: trmE; cd04164 218491022235 G1 box; other site 218491022236 GTP/Mg2+ binding site [chemical binding]; other site 218491022237 Switch I region; other site 218491022238 G2 box; other site 218491022239 Switch II region; other site 218491022240 G3 box; other site 218491022241 G4 box; other site 218491022242 G5 box; other site 218491022243 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 218491022244 HMMPfam hit to PF01926, DE GTPase of unknown function, score 1.1e-06 218491022245 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022246 HNH endonuclease; Region: HNH_2; pfam13391 218491022247 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 218491022248 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 218491022249 NADP binding site [chemical binding]; other site 218491022250 Predicted transcriptional regulators [Transcription]; Region: COG1733 218491022251 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 218491022252 HMMPfam hit to PF01638, DE Transcriptional regulator, score 1.2e-36 218491022253 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD; Region: PGA_PgaD; TIGR03940 218491022254 2 probable transmembrane helices predicted for ECA4451 by TMHMM2.0 at aa 20-42 and 57-79 218491022255 N-glycosyltransferase; Provisional; Region: PRK11204 218491022256 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 218491022257 DXD motif; other site 218491022258 5 probable transmembrane helices predicted for ECA4452 by TMHMM2.0 at aa 7-29, 39-61, 332-354, 369-388 and 401-423 218491022259 HMMPfam hit to PF00535, DE Glycosyl transferase, score 1.8e-37 218491022260 PS00606 Beta-ketoacyl synthases active site. 218491022261 Signal peptide predicted for ECA4452 by SignalP 2.0 HMM (Signal peptide probabilty 0.944) with cleavage site probability 0.498 between residues 31 and 32 218491022262 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 218491022263 Signal peptide predicted for ECA4453 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.670 between residues 22 and 23; signal peptide 218491022264 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 218491022265 putative active site [active] 218491022266 putative metal binding site [ion binding]; other site 218491022267 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022268 Signal peptide predicted for ECA4454 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.922 between residues 33 and 34; signal peptide 218491022269 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 218491022270 WYL domain; Region: WYL; pfam13280 218491022271 Pseudogene. This CDS appears to have a framshift mutation around codon 404. The framshift occurs within a polymeric tract of (G)10. Similar to Pseudomonas putida GGDEF domain protein pp3932 SWALL:AAN69526 (EMBL:AE016788) (402 aa) fasta scores: E(): 4.9e-10, 23.91% id in 230 aa; signal transduction protein (pseudogene) 218491022272 8 probable transmembrane helices predicted for ECA4456 by TMHMM2.0 at aa 5-27, 31-48, 61-80, 90-112, 125-147, 202-233, 240-262 and 277-296 218491022273 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00990, DE GGDEF domain, score 5.1e-06 218491022274 Signal peptide predicted for ECA4457 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.547 between residues 29 and 30; signal peptide 218491022275 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 218491022276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491022277 putative substrate translocation pore; other site 218491022278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218491022279 14 probable transmembrane helices predicted for ECA4457 by TMHMM2.0 at aa 9-31, 46-68, 75-94, 99-121, 134-156, 160-182, 195-214, 224-242, 263-285, 290-312, 325-347, 352-374, 395-417 and 464-486 218491022280 Signal peptide predicted for ECA4458 by SignalP 2.0 HMM (Signal peptide probabilty 0.954) with cleavage site probability 0.750 between residues 20 and 21; signal peptide 218491022281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 218491022282 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022283 Signal peptide predicted for ECA4459 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.543 between residues 22 and 23; signal peptide 218491022284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 218491022285 1 probable transmembrane helix predicted for ECA4459 by TMHMM2.0 at aa 7-29 218491022286 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022287 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 218491022288 Signal peptide predicted for ECA4460 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.481 between residues 30 and 31; signal peptide 218491022289 HMMPfam hit to PF03783, DE Curli production assembly/transport component CsgG, score 1.5e-57 218491022290 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022291 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022292 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 218491022293 4Fe-4S binding domain; Region: Fer4; pfam00037 218491022294 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 218491022295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218491022296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218491022297 PS00190 Cytochrome c family heme-binding site signature. 218491022298 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 5.8e-07 218491022299 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491022300 HMMPfam hit to PF00070, DE Pyridine nucleotide-disulphide oxidoreductase, score 2.4e-18 218491022301 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022302 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 218491022303 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 218491022304 HMMPfam hit to PF00037, DE 4Fe-4S binding domain, score 2e-07 218491022305 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218491022306 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 218491022307 1 probable transmembrane helix predicted for ECA4463 by TMHMM2.0 at aa 44-66 218491022308 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 218491022309 13 probable transmembrane helices predicted for ECA4464 by TMHMM2.0 at aa 7-26, 58-80, 87-109, 133-155, 167-186, 201-223, 230-252, 272-291, 320-342, 352-374, 381-399, 414-436 and 449-467 218491022310 HMMPfam hit to PF00860, DE Permease family, score 3.4e-19 218491022311 2 probable transmembrane helices predicted for ECA4465 by TMHMM2.0 at aa 21-43 and 58-80 218491022312 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 218491022313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218491022314 motif I; other site 218491022315 active site 218491022316 HMMPfam hit to PF00702, DE haloacid dehalogenase-like hydrolase, score 1.8e-21 218491022317 PS00215 Mitochondrial energy transfer proteins signature. 218491022318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022319 dimer interface [polypeptide binding]; other site 218491022320 conserved gate region; other site 218491022321 putative PBP binding loops; other site 218491022322 ABC-ATPase subunit interface; other site 218491022323 5 probable transmembrane helices predicted for ECA4467 by TMHMM2.0 at aa 27-49, 61-83, 93-115, 161-183 and 198-220 218491022324 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.9e-17 218491022325 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491022326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022327 dimer interface [polypeptide binding]; other site 218491022328 conserved gate region; other site 218491022329 putative PBP binding loops; other site 218491022330 ABC-ATPase subunit interface; other site 218491022331 4 probable transmembrane helices predicted for ECA4468 by TMHMM2.0 at aa 24-46, 66-88, 108-130 and 214-236 218491022332 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.1e-09 218491022333 Signal peptide predicted for ECA4470 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.962 between residues 23 and 24; signal peptide 218491022334 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491022335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491022336 substrate binding pocket [chemical binding]; other site 218491022337 membrane-bound complex binding site; other site 218491022338 hinge residues; other site 218491022339 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 6.4e-67 218491022340 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218491022341 Signal peptide predicted for ECA4471 by SignalP 2.0 HMM (Signal peptide probabilty 0.629) with cleavage site probability 0.416 between residues 44 and 45; signal peptide 218491022342 benzoate transporter; Region: benE; TIGR00843 218491022343 Benzoate membrane transport protein; Region: BenE; pfam03594 218491022344 HMMPfam hit to PF03594, DE Benzoate membrane transport protein, score 9.4e-185 218491022345 11 probable transmembrane helices predicted for ECA4471 by TMHMM2.0 at aa 20-42, 52-74, 79-98, 103-125, 132-153, 173-192, 213-235, 255-277, 297-318, 328-350 and 357-379 218491022346 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 218491022347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218491022348 non-specific DNA binding site [nucleotide binding]; other site 218491022349 salt bridge; other site 218491022350 sequence-specific DNA binding site [nucleotide binding]; other site 218491022351 Cupin domain; Region: Cupin_2; pfam07883 218491022352 HMMPfam hit to PF01381, DE Helix-turn-helix, score 1.5e-11 218491022353 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 23-44, sequence WSLTRAAEETGVSKAMLGQIER 218491022354 transcriptional regulator PhoU; Provisional; Region: PRK11115 218491022355 PhoU domain; Region: PhoU; pfam01895 218491022356 PhoU domain; Region: PhoU; pfam01895 218491022357 HMMPfam hit to PF01895, DE PhoU family, score 1.2e-30 218491022358 HMMPfam hit to PF01895, DE PhoU family, score 5.7e-33 218491022359 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 218491022360 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 218491022361 Walker A/P-loop; other site 218491022362 ATP binding site [chemical binding]; other site 218491022363 Q-loop/lid; other site 218491022364 ABC transporter signature motif; other site 218491022365 Walker B; other site 218491022366 D-loop; other site 218491022367 H-loop/switch region; other site 218491022368 HMMPfam hit to PF00005, DE ABC transporter, score 1e-71 218491022369 PS00211 ABC transporters family signature. 218491022370 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022371 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 218491022372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022373 dimer interface [polypeptide binding]; other site 218491022374 conserved gate region; other site 218491022375 putative PBP binding loops; other site 218491022376 ABC-ATPase subunit interface; other site 218491022377 6 probable transmembrane helices predicted for ECA4475 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290 218491022378 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4.6e-17 218491022379 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491022380 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 218491022381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022382 dimer interface [polypeptide binding]; other site 218491022383 conserved gate region; other site 218491022384 putative PBP binding loops; other site 218491022385 ABC-ATPase subunit interface; other site 218491022386 6 probable transmembrane helices predicted for ECA4476 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304 218491022387 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 4e-07 218491022388 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491022389 Signal peptide predicted for ECA4477 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.954 between residues 25 and 26; signal peptide 218491022390 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491022391 substrate binding pocket [chemical binding]; other site 218491022392 membrane-bound complex binding site; other site 218491022393 hinge residues; other site 218491022394 HMMPfam hit to PF01449, , score 8.7e-140 218491022395 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218491022396 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 218491022397 Walker A/P-loop; other site 218491022398 ATP binding site [chemical binding]; other site 218491022399 Q-loop/lid; other site 218491022400 ABC transporter signature motif; other site 218491022401 Walker B; other site 218491022402 D-loop; other site 218491022403 H-loop/switch region; other site 218491022404 HMMPfam hit to PF00005, DE ABC transporter, score 1.6e-71 218491022405 PS00211 ABC transporters family signature. 218491022406 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022408 dimer interface [polypeptide binding]; other site 218491022409 conserved gate region; other site 218491022410 putative PBP binding loops; other site 218491022411 ABC-ATPase subunit interface; other site 218491022412 3 probable transmembrane helices predicted for ECA4479 by TMHMM2.0 at aa 27-49, 69-91 and 197-219 218491022413 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 1e-15 218491022414 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491022415 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218491022416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218491022417 dimer interface [polypeptide binding]; other site 218491022418 conserved gate region; other site 218491022419 putative PBP binding loops; other site 218491022420 ABC-ATPase subunit interface; other site 218491022421 5 probable transmembrane helices predicted for ECA4480 by TMHMM2.0 at aa 20-42, 54-76, 91-113, 163-185 and 200-222 218491022422 HMMPfam hit to PF00528, DE Binding-protein-dependent transport system inner membrane component, score 2.6e-13 218491022423 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218491022424 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 218491022425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491022426 NAD(P) binding site [chemical binding]; other site 218491022427 active site 218491022428 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 3.9e-49 218491022429 Predicted helix-turn-helix motif with score 1129.000, SD 3.03 at aa 128-149, sequence INITSIAAIYNFNGNSVYHATK 218491022430 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 218491022431 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 218491022432 lipoyl-biotinyl attachment site [posttranslational modification]; other site 218491022433 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 218491022434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 218491022435 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 218491022436 putative dimerization interface [polypeptide binding]; other site 218491022437 HMMPfam hit to PF03466, DE LysR substrate binding domain, score 1.5e-33 218491022438 HMMPfam hit to PF00126, DE Bacterial regulatory helix-turn-helix protein, lysR family, score 6.4e-25 218491022439 PS00044 Bacterial regulatory proteins, lysR family signature. 218491022440 Predicted helix-turn-helix motif with score 1802.000, SD 5.32 at aa 16-37, sequence GSLTQAADILHIAQPALSQQLA 218491022441 aspartate aminotransferase; Provisional; Region: PRK05764 218491022442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218491022443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218491022444 homodimer interface [polypeptide binding]; other site 218491022445 catalytic residue [active] 218491022446 HMMPfam hit to PF00155, DE Aminotransferase class I and II, score 3.7e-64 218491022447 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218491022448 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 218491022449 putative active site [active] 218491022450 HMMPfam hit to PF03746, DE LamB/YcsF family, score 1.5e-89 218491022451 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 218491022452 HMMPfam hit to PF02626, DE Allophanate hydrolase subunit 2, score 4.9e-91 218491022453 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022454 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 218491022455 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 218491022456 HMMPfam hit to PF02682, DE Allophanate hydrolase subunit 1, score 1.4e-42 218491022457 Signal peptide predicted for ECA4489 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 24 and 25; signal peptide 218491022458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218491022459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218491022460 substrate binding pocket [chemical binding]; other site 218491022461 membrane-bound complex binding site; other site 218491022462 hinge residues; other site 218491022463 HMMPfam hit to PF00497, DE Bacterial extracellular solute-binding proteins, family 3, score 2.1e-51 218491022464 PS00443 Glutamine amidotransferases class-II active site. 218491022465 Signal peptide predicted for ECA4490 by SignalP 2.0 HMM (Signal peptide probabilty 0.919) with cleavage site probability 0.701 between residues 29 and 30; signal peptide 218491022466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218491022467 EamA-like transporter family; Region: EamA; pfam00892 218491022468 10 probable transmembrane helices predicted for ECA4490 by TMHMM2.0 at aa 5-22, 37-59, 71-93, 98-115, 122-144, 154-176, 189-211, 216-238, 245-267 and 273-292 218491022469 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022470 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 3.6e-16 218491022471 HMMPfam hit to PF00892, DE Integral membrane protein DUF6, score 6e-10 218491022472 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 218491022473 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218491022474 dimer interface [polypeptide binding]; other site 218491022475 active site 218491022476 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 1.6e-46 218491022477 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 6.5e-47 218491022478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218491022479 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 218491022480 NAD(P) binding site [chemical binding]; other site 218491022481 active site 218491022482 HMMPfam hit to PF00106, DE short chain dehydrogenase, score 4.3e-70 218491022483 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 218491022484 putative active site 1 [active] 218491022485 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 218491022486 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218491022487 dimer interface [polypeptide binding]; other site 218491022488 active site 218491022489 HMMPfam hit to PF02801, DE Beta-ketoacyl synthase, C-terminal domain, score 7.2e-36 218491022490 HMMPfam hit to PF00109, DE Beta-ketoacyl synthase, N-terminal domain, score 3.7e-08 218491022491 PS00606 Beta-ketoacyl synthases active site. 218491022492 Signal peptide predicted for ECA4495 by SignalP 2.0 HMM (Signal peptide probabilty 0.894) with cleavage site probability 0.494 between residues 22 and 23; signal peptide 218491022493 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 218491022494 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022495 Predicted exporter [General function prediction only]; Region: COG4258 218491022496 12 probable transmembrane helices predicted for ECA4496 by TMHMM2.0 at aa 12-34, 260-279, 286-308, 312-334, 355-377, 381-403, 430-452, 631-653, 660-682, 687-709, 716-738 and 743-765 218491022497 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 218491022498 Signal peptide predicted for ECA4497 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 18 and 19; signal peptide 218491022499 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 218491022500 active site 218491022501 HMMPfam hit to PF03061, DE Thioesterase superfamily, score 9.6e-12 218491022502 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218491022503 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 218491022504 Ligand binding site; other site 218491022505 Putative Catalytic site; other site 218491022506 DXD motif; other site 218491022507 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218491022508 putative acyl-acceptor binding pocket; other site 218491022509 HMMPfam hit to PF00535, DE Glycosyl transferase, score 2.6e-14 218491022510 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 218491022511 active site 2 [active] 218491022512 dimer interface [polypeptide binding]; other site 218491022513 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 218491022514 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491022515 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218491022516 acyl-activating enzyme (AAE) consensus motif; other site 218491022517 acyl-activating enzyme (AAE) consensus motif; other site 218491022518 active site 218491022519 AMP binding site [chemical binding]; other site 218491022520 CoA binding site [chemical binding]; other site 218491022521 HMMPfam hit to PF00501, DE AMP-binding enzyme, score 1.8e-05 218491022522 PS00455 AMP-binding domain signature. 218491022523 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022524 Predicted membrane protein [Function unknown]; Region: COG4648 218491022525 6 probable transmembrane helices predicted for ECA4502 by TMHMM2.0 at aa 7-26, 31-48, 55-77, 87-109, 138-157 and 162-184 218491022526 acyl carrier protein; Provisional; Region: PRK05350 218491022527 HMMPfam hit to PF00550, DE Phosphopantetheine attachment site, score 6.4e-11 218491022528 Phosphopantetheine attachment site; Region: PP-binding; cl09936 218491022529 PS00012 Phosphopantetheine attachment site. 218491022530 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 218491022531 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218491022532 putative acyl-acceptor binding pocket; other site 218491022533 HMMPfam hit to PF01553, DE Acyltransferase, score 1.1e-09 218491022534 1 probable transmembrane helix predicted for ECA4505 by TMHMM2.0 at aa 49-71 218491022535 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 218491022536 Signal peptide predicted for ECA4507 by SignalP 2.0 HMM (Signal peptide probabilty 0.873) with cleavage site probability 0.371 between residues 31 and 32; signal peptide 218491022537 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218491022538 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 218491022539 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 218491022540 glutaminase active site [active] 218491022541 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218491022542 dimer interface [polypeptide binding]; other site 218491022543 active site 218491022544 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218491022545 dimer interface [polypeptide binding]; other site 218491022546 active site 218491022547 HMMPfam hit to PF01380, DE SIS domain, score 2.1e-37 218491022548 HMMPfam hit to PF01380, DE SIS domain, score 1.1e-45 218491022549 HMMPfam hit to PF00310, DE Glutamine amidotransferases class-II, score 6.5e-88 218491022550 PS00443 Glutamine amidotransferases class-II active site. 218491022551 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 218491022552 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 218491022553 Substrate binding site; other site 218491022554 Mg++ binding site; other site 218491022555 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 218491022556 active site 218491022557 substrate binding site [chemical binding]; other site 218491022558 CoA binding site [chemical binding]; other site 218491022559 PS00101 Hexapeptide-repeat containing-transferases signature. 218491022560 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1e+02 218491022561 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 75 218491022562 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 6.2e+02 218491022563 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 1.2e+02 218491022564 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.8 218491022565 HMMPfam hit to PF00132, DE Bacterial transferase hexapeptide (three repeats), score 0.92 218491022566 HMMPfam hit to PF00483, DE Nucleotidyl transferase, score 9.1e-06 218491022567 Signal peptide predicted for ECA4510 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 37 and 38; signal peptide 218491022568 Right handed beta helix region; Region: Beta_helix; pfam13229 218491022569 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022570 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 218491022571 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 218491022572 gamma subunit interface [polypeptide binding]; other site 218491022573 epsilon subunit interface [polypeptide binding]; other site 218491022574 LBP interface [polypeptide binding]; other site 218491022575 HMMPfam hit to PF00401, DE ATP synthase, Delta/Epsilon chain, long alpha-helix domain, score 1.4e-10 218491022576 HMMPfam hit to PF02823, DE ATP synthase, Delta/Epsilon chain, beta-sandwich domain, score 4.5e-36 218491022577 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 218491022578 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218491022579 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 218491022580 alpha subunit interaction interface [polypeptide binding]; other site 218491022581 Walker A motif; other site 218491022582 ATP binding site [chemical binding]; other site 218491022583 Walker B motif; other site 218491022584 inhibitor binding site; inhibition site 218491022585 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218491022586 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00306, DE ATP synthase alpha/beta chain, C terminal domain, score 8e-52 218491022587 HMMPfam hit to PF00006, DE ATP synthase alpha/beta family, nucleotide-binding domain, score 2.8e-134 218491022588 PS00152 ATP synthase alpha and beta subunits signature. 218491022589 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022590 HMMPfam hit to PF02874, DE ATP synthase alpha/beta family, beta-barrel domain, score 1.3e-24 218491022591 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 218491022592 core domain interface [polypeptide binding]; other site 218491022593 delta subunit interface [polypeptide binding]; other site 218491022594 epsilon subunit interface [polypeptide binding]; other site 218491022595 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00231, DE ATP synthase, score 3.2e-168 218491022596 PS00153 ATP synthase gamma subunit signature. 218491022597 PS00041 Bacterial regulatory proteins, araC family signature. 218491022598 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 218491022599 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218491022600 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 218491022601 beta subunit interaction interface [polypeptide binding]; other site 218491022602 Walker A motif; other site 218491022603 ATP binding site [chemical binding]; other site 218491022604 Walker B motif; other site 218491022605 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218491022606 HMMPfam hit to PF00306, DE ATP synthase alpha/beta chain, C terminal domain, score 5.5e-27 218491022607 HMMPfam hit to PF00006, DE ATP synthase alpha/beta family, nucleotide-binding domain, score 5.7e-153 218491022608 PS00152 ATP synthase alpha and beta subunits signature. 218491022609 PS00017 ATP/GTP-binding site motif A (P-loop). 218491022610 HMMPfam hit to PF02874, DE ATP synthase alpha/beta family, beta-barrel domain, score 1.9e-16 218491022611 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 218491022612 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 218491022613 HMMPfam hit to PF00213, DE ATP synthase delta (OSCP) subunit, score 2.7e-63 218491022614 PS00389 ATP synthase delta (OSCP) subunit signature. 218491022615 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 218491022616 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 218491022617 This hit extended beyond the end of the feature by 1 aa and was clipped.; HMMPfam hit to PF00430, DE ATP synthase B/B' CF(0), score 8e-45 218491022618 1 probable transmembrane helix predicted for ECA4516 by TMHMM2.0 at aa 7-26 218491022619 Signal peptide predicted for ECA4517 by SignalP 2.0 HMM (Signal peptide probabilty 0.779) with cleavage site probability 0.568 between residues 23 and 24; signal peptide 218491022620 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 218491022621 HMMPfam hit to PF00137, DE ATP synthase subunit C, score 3.4e-24 218491022622 2 probable transmembrane helices predicted for ECA4517 by TMHMM2.0 at aa 10-32 and 53-75 218491022623 PS00605 ATP synthase c subunit signature. 218491022624 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 218491022625 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 218491022626 HMMPfam hit to PF00119, DE ATP synthase A chain, score 7.5e-62 218491022627 5 probable transmembrane helices predicted for ECA4518 by TMHMM2.0 at aa 26-48, 88-110, 139-161, 206-228 and 238-260 218491022628 PS00449 ATP synthase a subunit signature. 218491022629 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 218491022630 Signal peptide predicted for ECA4519 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.460 between residues 38 and 39; signal peptide 218491022631 HMMPfam hit to PF03899, DE ATP synthase I chain, score 6.7e-33 218491022632 4 probable transmembrane helices predicted for ECA4519 by TMHMM2.0 at aa 10-32, 39-61, 71-93 and 100-122 218491022633 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 218491022634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218491022635 S-adenosylmethionine binding site [chemical binding]; other site 218491022636 HMMPfam hit to PF02527, DE Glucose inhibited division protein, score 9.7e-81 218491022637 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 218491022638 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 218491022639 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 218491022640 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 218491022641 HMMPfam hit to PF01134, DE Glucose inhibited division protein A, score 0 218491022642 Predicted helix-turn-helix motif with score 1170.000, SD 3.17 at aa 596-617, sequence SSIGQASRISGITPAAISILLI 218491022643 PS01281 Glucose inhibited division protein A family signature 2. 218491022644 PS01280 Glucose inhibited division protein A family signature 1.