-- dump date 20140619_232259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1166016000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1166016000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1166016000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016000004 Walker A motif; other site 1166016000005 ATP binding site [chemical binding]; other site 1166016000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1166016000007 Walker B motif; other site 1166016000008 arginine finger; other site 1166016000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1166016000010 DnaA box-binding interface [nucleotide binding]; other site 1166016000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1166016000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1166016000013 putative DNA binding surface [nucleotide binding]; other site 1166016000014 dimer interface [polypeptide binding]; other site 1166016000015 beta-clamp/clamp loader binding surface; other site 1166016000016 beta-clamp/translesion DNA polymerase binding surface; other site 1166016000017 recF protein; Region: recf; TIGR00611 1166016000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016000019 Walker A/P-loop; other site 1166016000020 ATP binding site [chemical binding]; other site 1166016000021 Q-loop/lid; other site 1166016000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016000023 ABC transporter signature motif; other site 1166016000024 Walker B; other site 1166016000025 D-loop; other site 1166016000026 H-loop/switch region; other site 1166016000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1166016000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016000029 Mg2+ binding site [ion binding]; other site 1166016000030 G-X-G motif; other site 1166016000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1166016000032 anchoring element; other site 1166016000033 dimer interface [polypeptide binding]; other site 1166016000034 ATP binding site [chemical binding]; other site 1166016000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1166016000036 active site 1166016000037 putative metal-binding site [ion binding]; other site 1166016000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1166016000039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016000041 putative substrate translocation pore; other site 1166016000042 Cache domain; Region: Cache_1; pfam02743 1166016000043 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1166016000044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016000045 dimer interface [polypeptide binding]; other site 1166016000046 putative CheW interface [polypeptide binding]; other site 1166016000047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016000048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016000049 DNA binding site [nucleotide binding] 1166016000050 domain linker motif; other site 1166016000051 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166016000052 dimerization interface (closed form) [polypeptide binding]; other site 1166016000053 ligand binding site [chemical binding]; other site 1166016000054 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166016000055 active site 1166016000056 P-loop; other site 1166016000057 phosphorylation site [posttranslational modification] 1166016000058 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166016000059 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166016000060 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1166016000061 active site 1166016000062 methionine cluster; other site 1166016000063 phosphorylation site [posttranslational modification] 1166016000064 metal binding site [ion binding]; metal-binding site 1166016000065 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166016000066 beta-galactosidase; Region: BGL; TIGR03356 1166016000067 sugar phosphate phosphatase; Provisional; Region: PRK10513 1166016000068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016000069 active site 1166016000070 motif I; other site 1166016000071 motif II; other site 1166016000072 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166016000073 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1166016000074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016000075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016000076 dimerization interface [polypeptide binding]; other site 1166016000077 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166016000078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1166016000079 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1166016000080 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1166016000081 inhibitor site; inhibition site 1166016000082 active site 1166016000083 dimer interface [polypeptide binding]; other site 1166016000084 catalytic residue [active] 1166016000085 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1166016000086 active site 1166016000087 tetramer interface [polypeptide binding]; other site 1166016000088 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1166016000089 active site 1166016000090 tetramer interface [polypeptide binding]; other site 1166016000091 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166016000092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000093 dimer interface [polypeptide binding]; other site 1166016000094 conserved gate region; other site 1166016000095 putative PBP binding loops; other site 1166016000096 ABC-ATPase subunit interface; other site 1166016000097 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166016000098 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166016000099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000100 dimer interface [polypeptide binding]; other site 1166016000101 conserved gate region; other site 1166016000102 putative PBP binding loops; other site 1166016000103 ABC-ATPase subunit interface; other site 1166016000104 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1166016000105 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016000106 Walker A/P-loop; other site 1166016000107 ATP binding site [chemical binding]; other site 1166016000108 Q-loop/lid; other site 1166016000109 ABC transporter signature motif; other site 1166016000110 Walker B; other site 1166016000111 D-loop; other site 1166016000112 H-loop/switch region; other site 1166016000113 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016000114 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016000115 Walker A/P-loop; other site 1166016000116 ATP binding site [chemical binding]; other site 1166016000117 Q-loop/lid; other site 1166016000118 ABC transporter signature motif; other site 1166016000119 Walker B; other site 1166016000120 D-loop; other site 1166016000121 H-loop/switch region; other site 1166016000122 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016000123 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1166016000124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016000125 DNA-binding site [nucleotide binding]; DNA binding site 1166016000126 FCD domain; Region: FCD; pfam07729 1166016000127 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1166016000128 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1166016000129 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1166016000130 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1166016000131 active site 1166016000132 intersubunit interface [polypeptide binding]; other site 1166016000133 catalytic residue [active] 1166016000134 galactonate dehydratase; Provisional; Region: PRK14017 1166016000135 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1166016000136 putative active site pocket [active] 1166016000137 putative metal binding site [ion binding]; other site 1166016000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000139 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016000140 putative substrate translocation pore; other site 1166016000141 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1166016000142 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1166016000143 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016000144 Walker A/P-loop; other site 1166016000145 ATP binding site [chemical binding]; other site 1166016000146 Q-loop/lid; other site 1166016000147 ABC transporter signature motif; other site 1166016000148 Walker B; other site 1166016000149 D-loop; other site 1166016000150 H-loop/switch region; other site 1166016000151 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016000152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000153 dimer interface [polypeptide binding]; other site 1166016000154 conserved gate region; other site 1166016000155 putative PBP binding loops; other site 1166016000156 ABC-ATPase subunit interface; other site 1166016000157 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1166016000158 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1166016000159 active site 1166016000160 dimer interface [polypeptide binding]; other site 1166016000161 non-prolyl cis peptide bond; other site 1166016000162 insertion regions; other site 1166016000163 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1166016000164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016000165 substrate binding pocket [chemical binding]; other site 1166016000166 membrane-bound complex binding site; other site 1166016000167 hinge residues; other site 1166016000168 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166016000169 active site 1166016000170 P-loop; other site 1166016000171 phosphorylation site [posttranslational modification] 1166016000172 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166016000173 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166016000174 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1166016000175 beta-galactosidase; Region: BGL; TIGR03356 1166016000176 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1166016000177 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1166016000178 hypothetical protein; Provisional; Region: PRK11616 1166016000179 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1166016000180 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1166016000181 putative dimer interface [polypeptide binding]; other site 1166016000182 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1166016000183 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1166016000184 putative dimer interface [polypeptide binding]; other site 1166016000185 putative transporter; Validated; Region: PRK03818 1166016000186 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1166016000187 TrkA-C domain; Region: TrkA_C; pfam02080 1166016000188 TrkA-C domain; Region: TrkA_C; pfam02080 1166016000189 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1166016000190 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166016000191 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1166016000192 transmembrane helices; other site 1166016000193 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1166016000194 PAS domain; Region: PAS; smart00091 1166016000195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016000196 ATP binding site [chemical binding]; other site 1166016000197 Mg2+ binding site [ion binding]; other site 1166016000198 G-X-G motif; other site 1166016000199 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1166016000200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016000201 active site 1166016000202 phosphorylation site [posttranslational modification] 1166016000203 intermolecular recognition site; other site 1166016000204 dimerization interface [polypeptide binding]; other site 1166016000205 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1166016000206 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166016000207 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166016000208 peptide binding site [polypeptide binding]; other site 1166016000209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166016000210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000211 dimer interface [polypeptide binding]; other site 1166016000212 conserved gate region; other site 1166016000213 putative PBP binding loops; other site 1166016000214 ABC-ATPase subunit interface; other site 1166016000215 dipeptide transporter; Provisional; Region: PRK10913 1166016000216 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166016000217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000218 dimer interface [polypeptide binding]; other site 1166016000219 conserved gate region; other site 1166016000220 putative PBP binding loops; other site 1166016000221 ABC-ATPase subunit interface; other site 1166016000222 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1166016000223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016000224 Walker A/P-loop; other site 1166016000225 ATP binding site [chemical binding]; other site 1166016000226 Q-loop/lid; other site 1166016000227 ABC transporter signature motif; other site 1166016000228 Walker B; other site 1166016000229 D-loop; other site 1166016000230 H-loop/switch region; other site 1166016000231 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166016000232 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1166016000233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016000234 Walker A/P-loop; other site 1166016000235 ATP binding site [chemical binding]; other site 1166016000236 Q-loop/lid; other site 1166016000237 ABC transporter signature motif; other site 1166016000238 Walker B; other site 1166016000239 D-loop; other site 1166016000240 H-loop/switch region; other site 1166016000241 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166016000242 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 1166016000243 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016000244 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1166016000245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016000246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016000247 homodimer interface [polypeptide binding]; other site 1166016000248 catalytic residue [active] 1166016000249 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1166016000250 active site 1166016000251 catalytic residues [active] 1166016000252 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1166016000253 EamA-like transporter family; Region: EamA; pfam00892 1166016000254 altronate oxidoreductase; Provisional; Region: PRK03643 1166016000255 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166016000256 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166016000257 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1166016000258 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1166016000259 putative NAD(P) binding site [chemical binding]; other site 1166016000260 catalytic Zn binding site [ion binding]; other site 1166016000261 structural Zn binding site [ion binding]; other site 1166016000262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016000263 DNA-binding site [nucleotide binding]; DNA binding site 1166016000264 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166016000265 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166016000266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000267 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016000268 putative substrate translocation pore; other site 1166016000269 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1166016000270 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1166016000271 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 1166016000272 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1166016000273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016000274 binding surface 1166016000275 TPR motif; other site 1166016000276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016000277 binding surface 1166016000278 TPR motif; other site 1166016000279 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1166016000280 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1166016000281 cellulose synthase regulator protein; Provisional; Region: PRK11114 1166016000282 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1166016000283 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1166016000284 DXD motif; other site 1166016000285 PilZ domain; Region: PilZ; pfam07238 1166016000286 YhjQ protein; Region: YhjQ; pfam06564 1166016000287 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166016000288 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1166016000289 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1166016000290 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1166016000291 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1166016000292 putative diguanylate cyclase; Provisional; Region: PRK13561 1166016000293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016000294 metal binding site [ion binding]; metal-binding site 1166016000295 active site 1166016000296 I-site; other site 1166016000297 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1166016000298 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166016000299 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1166016000300 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1166016000301 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166016000302 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016000303 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1166016000304 substrate binding site [chemical binding]; other site 1166016000305 ATP binding site [chemical binding]; other site 1166016000306 inner membrane protein YhjD; Region: TIGR00766 1166016000307 major facilitator superfamily transporter; Provisional; Region: PRK05122 1166016000308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000309 putative substrate translocation pore; other site 1166016000310 hypothetical protein; Provisional; Region: PRK11615 1166016000311 hypothetical protein; Provisional; Region: PRK11212 1166016000312 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1166016000313 CPxP motif; other site 1166016000314 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1166016000315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166016000316 metal-binding site [ion binding] 1166016000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166016000318 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166016000319 Predicted membrane protein [Function unknown]; Region: COG3714 1166016000320 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 1166016000321 hypothetical protein; Provisional; Region: PRK10910 1166016000322 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1166016000323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016000324 S-adenosylmethionine binding site [chemical binding]; other site 1166016000325 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1166016000326 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1166016000327 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1166016000328 P loop; other site 1166016000329 GTP binding site [chemical binding]; other site 1166016000330 cell division protein FtsE; Provisional; Region: PRK10908 1166016000331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016000332 Walker A/P-loop; other site 1166016000333 ATP binding site [chemical binding]; other site 1166016000334 Q-loop/lid; other site 1166016000335 ABC transporter signature motif; other site 1166016000336 Walker B; other site 1166016000337 D-loop; other site 1166016000338 H-loop/switch region; other site 1166016000339 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1166016000340 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1166016000341 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1166016000342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016000343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016000344 DNA binding residues [nucleotide binding] 1166016000345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016000346 Coenzyme A binding pocket [chemical binding]; other site 1166016000347 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1166016000348 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1166016000349 dimerization interface [polypeptide binding]; other site 1166016000350 ligand binding site [chemical binding]; other site 1166016000351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016000352 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1166016000353 TM-ABC transporter signature motif; other site 1166016000354 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1166016000355 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1166016000356 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1166016000357 TM-ABC transporter signature motif; other site 1166016000358 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1166016000359 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1166016000360 Walker A/P-loop; other site 1166016000361 ATP binding site [chemical binding]; other site 1166016000362 Q-loop/lid; other site 1166016000363 ABC transporter signature motif; other site 1166016000364 Walker B; other site 1166016000365 D-loop; other site 1166016000366 H-loop/switch region; other site 1166016000367 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1166016000368 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1166016000369 Walker A/P-loop; other site 1166016000370 ATP binding site [chemical binding]; other site 1166016000371 Q-loop/lid; other site 1166016000372 ABC transporter signature motif; other site 1166016000373 Walker B; other site 1166016000374 D-loop; other site 1166016000375 H-loop/switch region; other site 1166016000376 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1166016000377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016000378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016000379 homodimer interface [polypeptide binding]; other site 1166016000380 catalytic residue [active] 1166016000381 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016000382 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016000383 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016000384 dimer interface [polypeptide binding]; other site 1166016000385 putative CheW interface [polypeptide binding]; other site 1166016000386 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016000387 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016000388 HAMP domain; Region: HAMP; pfam00672 1166016000389 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016000390 dimer interface [polypeptide binding]; other site 1166016000391 putative CheW interface [polypeptide binding]; other site 1166016000392 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016000393 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016000394 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016000395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016000396 dimer interface [polypeptide binding]; other site 1166016000397 putative CheW interface [polypeptide binding]; other site 1166016000398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016000399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016000400 dimer interface [polypeptide binding]; other site 1166016000401 putative CheW interface [polypeptide binding]; other site 1166016000402 putative transporter; Provisional; Region: PRK09821 1166016000403 GntP family permease; Region: GntP_permease; pfam02447 1166016000404 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1166016000405 putative aldolase; Validated; Region: PRK08130 1166016000406 intersubunit interface [polypeptide binding]; other site 1166016000407 active site 1166016000408 Zn2+ binding site [ion binding]; other site 1166016000409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1166016000410 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1166016000411 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1166016000412 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166016000413 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1166016000414 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016000415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1166016000416 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1166016000417 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1166016000418 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1166016000419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166016000420 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1166016000421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000422 dimer interface [polypeptide binding]; other site 1166016000423 conserved gate region; other site 1166016000424 putative PBP binding loops; other site 1166016000425 ABC-ATPase subunit interface; other site 1166016000426 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166016000427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000428 dimer interface [polypeptide binding]; other site 1166016000429 conserved gate region; other site 1166016000430 putative PBP binding loops; other site 1166016000431 ABC-ATPase subunit interface; other site 1166016000432 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1166016000433 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166016000434 Walker A/P-loop; other site 1166016000435 ATP binding site [chemical binding]; other site 1166016000436 Q-loop/lid; other site 1166016000437 ABC transporter signature motif; other site 1166016000438 Walker B; other site 1166016000439 D-loop; other site 1166016000440 H-loop/switch region; other site 1166016000441 TOBE domain; Region: TOBE_2; pfam08402 1166016000442 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1166016000443 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1166016000444 putative active site [active] 1166016000445 catalytic site [active] 1166016000446 putative metal binding site [ion binding]; other site 1166016000447 Predicted permeases [General function prediction only]; Region: COG0679 1166016000448 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1166016000449 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1166016000450 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1166016000451 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1166016000452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016000453 dimerization interface [polypeptide binding]; other site 1166016000454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016000455 dimer interface [polypeptide binding]; other site 1166016000456 phosphorylation site [posttranslational modification] 1166016000457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016000458 ATP binding site [chemical binding]; other site 1166016000459 Mg2+ binding site [ion binding]; other site 1166016000460 G-X-G motif; other site 1166016000461 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1166016000462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016000463 active site 1166016000464 phosphorylation site [posttranslational modification] 1166016000465 intermolecular recognition site; other site 1166016000466 dimerization interface [polypeptide binding]; other site 1166016000467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016000468 DNA binding site [nucleotide binding] 1166016000469 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1166016000470 dimer interface [polypeptide binding]; other site 1166016000471 HEAT repeats; Region: HEAT_2; pfam13646 1166016000472 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1166016000473 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1166016000474 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1166016000475 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1166016000476 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1166016000477 metal ion-dependent adhesion site (MIDAS); other site 1166016000478 SWIM zinc finger; Region: SWIM; pfam04434 1166016000479 putative arabinose transporter; Provisional; Region: PRK03545 1166016000480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000481 putative substrate translocation pore; other site 1166016000482 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1166016000483 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1166016000484 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1166016000485 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1166016000486 active site 1166016000487 ADP/pyrophosphate binding site [chemical binding]; other site 1166016000488 dimerization interface [polypeptide binding]; other site 1166016000489 allosteric effector site; other site 1166016000490 fructose-1,6-bisphosphate binding site; other site 1166016000491 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016000492 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016000493 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016000494 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1166016000495 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1166016000496 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1166016000497 PAAR motif; Region: PAAR_motif; pfam05488 1166016000498 RHS Repeat; Region: RHS_repeat; pfam05593 1166016000499 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016000500 RHS Repeat; Region: RHS_repeat; cl11982 1166016000501 RHS Repeat; Region: RHS_repeat; pfam05593 1166016000502 RHS Repeat; Region: RHS_repeat; pfam05593 1166016000503 RHS Repeat; Region: RHS_repeat; pfam05593 1166016000504 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166016000505 RHS Repeat; Region: RHS_repeat; cl11982 1166016000506 RHS Repeat; Region: RHS_repeat; pfam05593 1166016000507 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016000508 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016000509 RHS Repeat; Region: RHS_repeat; pfam05593 1166016000510 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016000511 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016000512 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1166016000513 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1166016000514 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016000515 RHS Repeat; Region: RHS_repeat; cl11982 1166016000516 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016000517 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 1166016000518 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016000519 dipeptidase PepV; Region: dipeptidase; TIGR01886 1166016000520 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1166016000521 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1166016000522 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1166016000523 putative active site; other site 1166016000524 catalytic triad [active] 1166016000525 putative dimer interface [polypeptide binding]; other site 1166016000526 agmatine deiminase; Provisional; Region: PRK13551 1166016000527 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1166016000528 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1166016000529 triosephosphate isomerase; Provisional; Region: PRK14567 1166016000530 substrate binding site [chemical binding]; other site 1166016000531 dimer interface [polypeptide binding]; other site 1166016000532 catalytic triad [active] 1166016000533 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1166016000534 Predicted membrane protein [Function unknown]; Region: COG3152 1166016000535 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1166016000536 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1166016000537 FAD binding pocket [chemical binding]; other site 1166016000538 FAD binding motif [chemical binding]; other site 1166016000539 phosphate binding motif [ion binding]; other site 1166016000540 beta-alpha-beta structure motif; other site 1166016000541 NAD binding pocket [chemical binding]; other site 1166016000542 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1166016000543 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1166016000544 putative active site [active] 1166016000545 glycerol kinase; Provisional; Region: glpK; PRK00047 1166016000546 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1166016000547 N- and C-terminal domain interface [polypeptide binding]; other site 1166016000548 active site 1166016000549 MgATP binding site [chemical binding]; other site 1166016000550 catalytic site [active] 1166016000551 metal binding site [ion binding]; metal-binding site 1166016000552 glycerol binding site [chemical binding]; other site 1166016000553 homotetramer interface [polypeptide binding]; other site 1166016000554 homodimer interface [polypeptide binding]; other site 1166016000555 FBP binding site [chemical binding]; other site 1166016000556 protein IIAGlc interface [polypeptide binding]; other site 1166016000557 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1166016000558 amphipathic channel; other site 1166016000559 Asn-Pro-Ala signature motifs; other site 1166016000560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 1166016000561 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1166016000562 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1166016000563 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166016000564 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1166016000565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016000566 Walker A motif; other site 1166016000567 ATP binding site [chemical binding]; other site 1166016000568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016000569 Walker B motif; other site 1166016000570 arginine finger; other site 1166016000571 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166016000572 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1166016000573 active site 1166016000574 HslU subunit interaction site [polypeptide binding]; other site 1166016000575 essential cell division protein FtsN; Provisional; Region: PRK10927 1166016000576 cell division protein FtsN; Provisional; Region: PRK12757 1166016000577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016000578 DNA binding site [nucleotide binding] 1166016000579 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1166016000580 domain linker motif; other site 1166016000581 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1166016000582 dimerization interface [polypeptide binding]; other site 1166016000583 ligand binding site [chemical binding]; other site 1166016000584 primosome assembly protein PriA; Validated; Region: PRK05580 1166016000585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016000586 ATP binding site [chemical binding]; other site 1166016000587 putative Mg++ binding site [ion binding]; other site 1166016000588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1166016000589 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1166016000590 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016000591 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016000592 ABC-ATPase subunit interface; other site 1166016000593 dimer interface [polypeptide binding]; other site 1166016000594 putative PBP binding regions; other site 1166016000595 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1166016000596 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1166016000597 putative ligand binding residues [chemical binding]; other site 1166016000598 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016000599 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016000600 Walker A/P-loop; other site 1166016000601 ATP binding site [chemical binding]; other site 1166016000602 Q-loop/lid; other site 1166016000603 ABC transporter signature motif; other site 1166016000604 Walker B; other site 1166016000605 D-loop; other site 1166016000606 H-loop/switch region; other site 1166016000607 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1166016000608 dimerization interface [polypeptide binding]; other site 1166016000609 DNA binding site [nucleotide binding] 1166016000610 corepressor binding sites; other site 1166016000611 cystathionine gamma-synthase; Provisional; Region: PRK08045 1166016000612 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166016000613 homodimer interface [polypeptide binding]; other site 1166016000614 substrate-cofactor binding pocket; other site 1166016000615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016000616 catalytic residue [active] 1166016000617 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1166016000618 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1166016000619 putative catalytic residues [active] 1166016000620 putative nucleotide binding site [chemical binding]; other site 1166016000621 putative aspartate binding site [chemical binding]; other site 1166016000622 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166016000623 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1166016000624 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1166016000625 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1166016000626 FAD binding site [chemical binding]; other site 1166016000627 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1166016000628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016000629 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1166016000630 dimerization interface [polypeptide binding]; other site 1166016000631 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1166016000632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016000633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1166016000634 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1166016000635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016000636 hypothetical protein; Provisional; Region: PRK11056 1166016000637 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1166016000638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016000639 S-adenosylmethionine binding site [chemical binding]; other site 1166016000640 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1166016000641 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016000642 N-terminal plug; other site 1166016000643 ligand-binding site [chemical binding]; other site 1166016000644 glutamate racemase; Provisional; Region: PRK00865 1166016000645 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1166016000646 FAD binding domain; Region: FAD_binding_4; pfam01565 1166016000647 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1166016000648 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1166016000649 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1166016000650 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1166016000651 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1166016000652 pantothenate kinase; Provisional; Region: PRK05439 1166016000653 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1166016000654 ATP-binding site [chemical binding]; other site 1166016000655 CoA-binding site [chemical binding]; other site 1166016000656 Mg2+-binding site [ion binding]; other site 1166016000657 elongation factor Tu; Reviewed; Region: PRK00049 1166016000658 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1166016000659 G1 box; other site 1166016000660 GEF interaction site [polypeptide binding]; other site 1166016000661 GTP/Mg2+ binding site [chemical binding]; other site 1166016000662 Switch I region; other site 1166016000663 G2 box; other site 1166016000664 G3 box; other site 1166016000665 Switch II region; other site 1166016000666 G4 box; other site 1166016000667 G5 box; other site 1166016000668 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1166016000669 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1166016000670 Antibiotic Binding Site [chemical binding]; other site 1166016000671 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1166016000672 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1166016000673 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1166016000674 putative homodimer interface [polypeptide binding]; other site 1166016000675 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1166016000676 heterodimer interface [polypeptide binding]; other site 1166016000677 homodimer interface [polypeptide binding]; other site 1166016000678 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1166016000679 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1166016000680 23S rRNA interface [nucleotide binding]; other site 1166016000681 L7/L12 interface [polypeptide binding]; other site 1166016000682 putative thiostrepton binding site; other site 1166016000683 L25 interface [polypeptide binding]; other site 1166016000684 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1166016000685 mRNA/rRNA interface [nucleotide binding]; other site 1166016000686 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1166016000687 23S rRNA interface [nucleotide binding]; other site 1166016000688 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1166016000689 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1166016000690 core dimer interface [polypeptide binding]; other site 1166016000691 peripheral dimer interface [polypeptide binding]; other site 1166016000692 L10 interface [polypeptide binding]; other site 1166016000693 L11 interface [polypeptide binding]; other site 1166016000694 putative EF-Tu interaction site [polypeptide binding]; other site 1166016000695 putative EF-G interaction site [polypeptide binding]; other site 1166016000696 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1166016000697 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1166016000698 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1166016000699 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1166016000700 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1166016000701 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1166016000702 RPB3 interaction site [polypeptide binding]; other site 1166016000703 RPB1 interaction site [polypeptide binding]; other site 1166016000704 RPB11 interaction site [polypeptide binding]; other site 1166016000705 RPB10 interaction site [polypeptide binding]; other site 1166016000706 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1166016000707 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1166016000708 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1166016000709 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1166016000710 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1166016000711 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1166016000712 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1166016000713 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1166016000714 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1166016000715 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1166016000716 DNA binding site [nucleotide binding] 1166016000717 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1166016000718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000719 putative substrate translocation pore; other site 1166016000720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016000721 putative substrate translocation pore; other site 1166016000722 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 1166016000723 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166016000724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016000725 DNA-binding site [nucleotide binding]; DNA binding site 1166016000726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016000727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016000728 homodimer interface [polypeptide binding]; other site 1166016000729 catalytic residue [active] 1166016000730 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1166016000731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016000732 FeS/SAM binding site; other site 1166016000733 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1166016000734 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1166016000735 ThiS interaction site; other site 1166016000736 putative active site [active] 1166016000737 tetramer interface [polypeptide binding]; other site 1166016000738 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1166016000739 thiS-thiF/thiG interaction site; other site 1166016000740 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1166016000741 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1166016000742 ATP binding site [chemical binding]; other site 1166016000743 substrate interface [chemical binding]; other site 1166016000744 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1166016000745 thiamine phosphate binding site [chemical binding]; other site 1166016000746 active site 1166016000747 pyrophosphate binding site [ion binding]; other site 1166016000748 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1166016000749 ThiC-associated domain; Region: ThiC-associated; pfam13667 1166016000750 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1166016000751 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1166016000752 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1166016000753 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1166016000754 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1166016000755 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1166016000756 putative NADH binding site [chemical binding]; other site 1166016000757 putative active site [active] 1166016000758 nudix motif; other site 1166016000759 putative metal binding site [ion binding]; other site 1166016000760 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1166016000761 substrate binding site [chemical binding]; other site 1166016000762 active site 1166016000763 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1166016000764 Active_site [active] 1166016000765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1166016000766 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166016000767 IHF dimer interface [polypeptide binding]; other site 1166016000768 IHF - DNA interface [nucleotide binding]; other site 1166016000769 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1166016000770 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1166016000771 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1166016000772 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1166016000773 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1166016000774 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1166016000775 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1166016000776 purine monophosphate binding site [chemical binding]; other site 1166016000777 dimer interface [polypeptide binding]; other site 1166016000778 putative catalytic residues [active] 1166016000779 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1166016000780 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1166016000781 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016000782 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016000783 Walker A/P-loop; other site 1166016000784 ATP binding site [chemical binding]; other site 1166016000785 Q-loop/lid; other site 1166016000786 ABC transporter signature motif; other site 1166016000787 Walker B; other site 1166016000788 D-loop; other site 1166016000789 H-loop/switch region; other site 1166016000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000791 dimer interface [polypeptide binding]; other site 1166016000792 conserved gate region; other site 1166016000793 putative PBP binding loops; other site 1166016000794 ABC-ATPase subunit interface; other site 1166016000795 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1166016000796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000797 conserved gate region; other site 1166016000798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000799 dimer interface [polypeptide binding]; other site 1166016000800 ABC-ATPase subunit interface; other site 1166016000801 putative PBP binding loops; other site 1166016000802 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1166016000803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016000804 substrate binding pocket [chemical binding]; other site 1166016000805 membrane-bound complex binding site; other site 1166016000806 hinge residues; other site 1166016000807 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016000808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016000809 dimer interface [polypeptide binding]; other site 1166016000810 conserved gate region; other site 1166016000811 putative PBP binding loops; other site 1166016000812 ABC-ATPase subunit interface; other site 1166016000813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016000814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016000815 substrate binding pocket [chemical binding]; other site 1166016000816 membrane-bound complex binding site; other site 1166016000817 hinge residues; other site 1166016000818 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1166016000819 putative catalytic site [active] 1166016000820 putative phosphate binding site [ion binding]; other site 1166016000821 putative metal binding site [ion binding]; other site 1166016000822 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1166016000823 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1166016000824 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1166016000825 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1166016000826 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1166016000827 FMN binding site [chemical binding]; other site 1166016000828 active site 1166016000829 catalytic residues [active] 1166016000830 substrate binding site [chemical binding]; other site 1166016000831 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1166016000832 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1166016000833 active site 1166016000834 zinc binding site [ion binding]; other site 1166016000835 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1166016000836 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1166016000837 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1166016000838 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1166016000839 Na binding site [ion binding]; other site 1166016000840 hypothetical protein; Provisional; Region: PRK10633 1166016000841 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1166016000842 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1166016000843 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1166016000844 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1166016000845 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016000846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016000847 ABC-ATPase subunit interface; other site 1166016000848 dimer interface [polypeptide binding]; other site 1166016000849 putative PBP binding regions; other site 1166016000850 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016000851 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016000852 Walker A/P-loop; other site 1166016000853 ATP binding site [chemical binding]; other site 1166016000854 Q-loop/lid; other site 1166016000855 ABC transporter signature motif; other site 1166016000856 Walker B; other site 1166016000857 D-loop; other site 1166016000858 H-loop/switch region; other site 1166016000859 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166016000860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016000861 S-adenosylmethionine binding site [chemical binding]; other site 1166016000862 molybdenum transport protein ModD; Provisional; Region: PRK06096 1166016000863 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1166016000864 dimerization interface [polypeptide binding]; other site 1166016000865 active site 1166016000866 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1166016000867 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016000868 N-terminal plug; other site 1166016000869 ligand-binding site [chemical binding]; other site 1166016000870 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1166016000871 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166016000872 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1166016000873 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1166016000874 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1166016000875 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166016000876 carboxyltransferase (CT) interaction site; other site 1166016000877 biotinylation site [posttranslational modification]; other site 1166016000878 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1166016000879 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1166016000880 active site 1166016000881 trimer interface [polypeptide binding]; other site 1166016000882 dimer interface [polypeptide binding]; other site 1166016000883 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1166016000884 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1166016000885 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1166016000886 Moco binding site; other site 1166016000887 metal coordination site [ion binding]; other site 1166016000888 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1166016000889 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1166016000890 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1166016000891 NADP binding site [chemical binding]; other site 1166016000892 dimer interface [polypeptide binding]; other site 1166016000893 regulatory protein CsrD; Provisional; Region: PRK11059 1166016000894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016000895 metal binding site [ion binding]; metal-binding site 1166016000896 active site 1166016000897 I-site; other site 1166016000898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016000899 rod shape-determining protein MreB; Provisional; Region: PRK13927 1166016000900 MreB and similar proteins; Region: MreB_like; cd10225 1166016000901 nucleotide binding site [chemical binding]; other site 1166016000902 Mg binding site [ion binding]; other site 1166016000903 putative protofilament interaction site [polypeptide binding]; other site 1166016000904 RodZ interaction site [polypeptide binding]; other site 1166016000905 rod shape-determining protein MreC; Region: mreC; TIGR00219 1166016000906 rod shape-determining protein MreC; Region: MreC; pfam04085 1166016000907 rod shape-determining protein MreD; Provisional; Region: PRK11060 1166016000908 Maf-like protein; Region: Maf; pfam02545 1166016000909 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1166016000910 active site 1166016000911 dimer interface [polypeptide binding]; other site 1166016000912 ribonuclease G; Provisional; Region: PRK11712 1166016000913 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1166016000914 homodimer interface [polypeptide binding]; other site 1166016000915 oligonucleotide binding site [chemical binding]; other site 1166016000916 hypothetical protein; Provisional; Region: PRK10899 1166016000917 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1166016000918 protease TldD; Provisional; Region: tldD; PRK10735 1166016000919 transcriptional regulator; Provisional; Region: PRK10632 1166016000920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016000921 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166016000922 putative effector binding pocket; other site 1166016000923 dimerization interface [polypeptide binding]; other site 1166016000924 efflux system membrane protein; Provisional; Region: PRK11594 1166016000925 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1166016000926 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016000927 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016000928 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1166016000929 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166016000930 hypothetical protein; Provisional; Region: PRK05255 1166016000931 peptidase PmbA; Provisional; Region: PRK11040 1166016000932 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1166016000933 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1166016000934 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1166016000935 dimerization domain swap beta strand [polypeptide binding]; other site 1166016000936 regulatory protein interface [polypeptide binding]; other site 1166016000937 active site 1166016000938 regulatory phosphorylation site [posttranslational modification]; other site 1166016000939 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1166016000940 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016000941 active site 1166016000942 phosphorylation site [posttranslational modification] 1166016000943 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1166016000944 30S subunit binding site; other site 1166016000945 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1166016000946 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1166016000947 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1166016000948 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1166016000949 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1166016000950 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1166016000951 Walker A/P-loop; other site 1166016000952 ATP binding site [chemical binding]; other site 1166016000953 Q-loop/lid; other site 1166016000954 ABC transporter signature motif; other site 1166016000955 Walker B; other site 1166016000956 D-loop; other site 1166016000957 H-loop/switch region; other site 1166016000958 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1166016000959 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1166016000960 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1166016000961 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1166016000962 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1166016000963 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1166016000964 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1166016000965 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1166016000966 putative active site [active] 1166016000967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1166016000968 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1166016000969 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1166016000970 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1166016000971 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1166016000972 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1166016000973 Walker A/P-loop; other site 1166016000974 ATP binding site [chemical binding]; other site 1166016000975 Q-loop/lid; other site 1166016000976 ABC transporter signature motif; other site 1166016000977 Walker B; other site 1166016000978 D-loop; other site 1166016000979 H-loop/switch region; other site 1166016000980 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1166016000981 conserved hypothetical integral membrane protein; Region: TIGR00056 1166016000982 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1166016000983 mce related protein; Region: MCE; pfam02470 1166016000984 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1166016000985 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1166016000986 anti sigma factor interaction site; other site 1166016000987 regulatory phosphorylation site [posttranslational modification]; other site 1166016000988 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1166016000989 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1166016000990 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1166016000991 hinge; other site 1166016000992 active site 1166016000993 serine endoprotease; Provisional; Region: PRK10898 1166016000994 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1166016000995 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166016000996 protein binding site [polypeptide binding]; other site 1166016000997 serine endoprotease; Provisional; Region: PRK10139 1166016000998 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1166016000999 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166016001000 protein binding site [polypeptide binding]; other site 1166016001001 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166016001002 hypothetical protein; Provisional; Region: PRK11677 1166016001003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1166016001004 Predicted ATPase [General function prediction only]; Region: COG1485 1166016001005 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1166016001006 23S rRNA interface [nucleotide binding]; other site 1166016001007 L3 interface [polypeptide binding]; other site 1166016001008 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1166016001009 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1166016001010 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1166016001011 C-terminal domain interface [polypeptide binding]; other site 1166016001012 putative GSH binding site (G-site) [chemical binding]; other site 1166016001013 dimer interface [polypeptide binding]; other site 1166016001014 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1166016001015 dimer interface [polypeptide binding]; other site 1166016001016 N-terminal domain interface [polypeptide binding]; other site 1166016001017 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1166016001018 acetoin reductase; Validated; Region: PRK08643 1166016001019 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1166016001020 NAD binding site [chemical binding]; other site 1166016001021 homotetramer interface [polypeptide binding]; other site 1166016001022 homodimer interface [polypeptide binding]; other site 1166016001023 active site 1166016001024 substrate binding site [chemical binding]; other site 1166016001025 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1166016001026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016001027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016001028 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1166016001029 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1166016001030 active site 1166016001031 dimer interface [polypeptide binding]; other site 1166016001032 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1166016001033 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1166016001034 active site 1166016001035 FMN binding site [chemical binding]; other site 1166016001036 substrate binding site [chemical binding]; other site 1166016001037 3Fe-4S cluster binding site [ion binding]; other site 1166016001038 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1166016001039 domain interface; other site 1166016001040 radical SAM protein, TIGR01212 family; Region: TIGR01212 1166016001041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016001042 FeS/SAM binding site; other site 1166016001043 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1166016001044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016001045 putative active site [active] 1166016001046 heme pocket [chemical binding]; other site 1166016001047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016001048 dimer interface [polypeptide binding]; other site 1166016001049 phosphorylation site [posttranslational modification] 1166016001050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016001051 ATP binding site [chemical binding]; other site 1166016001052 Mg2+ binding site [ion binding]; other site 1166016001053 G-X-G motif; other site 1166016001054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016001055 active site 1166016001056 phosphorylation site [posttranslational modification] 1166016001057 intermolecular recognition site; other site 1166016001058 dimerization interface [polypeptide binding]; other site 1166016001059 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166016001060 putative binding surface; other site 1166016001061 active site 1166016001062 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1166016001063 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1166016001064 conserved cys residue [active] 1166016001065 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1166016001066 Transglycosylase; Region: Transgly; cl17702 1166016001067 Alginate lyase; Region: Alginate_lyase; pfam05426 1166016001068 outer membrane lipoprotein; Provisional; Region: PRK11023 1166016001069 BON domain; Region: BON; pfam04972 1166016001070 BON domain; Region: BON; pfam04972 1166016001071 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1166016001072 dimer interface [polypeptide binding]; other site 1166016001073 active site 1166016001074 hypothetical protein; Reviewed; Region: PRK12497 1166016001075 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1166016001076 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1166016001077 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1166016001078 putative ligand binding site [chemical binding]; other site 1166016001079 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1166016001080 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1166016001081 putative SAM binding site [chemical binding]; other site 1166016001082 putative homodimer interface [polypeptide binding]; other site 1166016001083 primosomal protein DnaI; Provisional; Region: PRK02854 1166016001084 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1166016001085 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1166016001086 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1166016001087 putative active site [active] 1166016001088 metal binding site [ion binding]; metal-binding site 1166016001089 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1166016001090 hypothetical protein; Provisional; Region: PRK11653 1166016001091 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1166016001092 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1166016001093 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166016001094 dimer interface [polypeptide binding]; other site 1166016001095 ADP-ribose binding site [chemical binding]; other site 1166016001096 active site 1166016001097 nudix motif; other site 1166016001098 metal binding site [ion binding]; metal-binding site 1166016001099 putative dehydrogenase; Provisional; Region: PRK11039 1166016001100 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1166016001101 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166016001102 active site 1166016001103 metal binding site [ion binding]; metal-binding site 1166016001104 hexamer interface [polypeptide binding]; other site 1166016001105 esterase YqiA; Provisional; Region: PRK11071 1166016001106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166016001107 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1166016001108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016001109 ATP binding site [chemical binding]; other site 1166016001110 Mg2+ binding site [ion binding]; other site 1166016001111 G-X-G motif; other site 1166016001112 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1166016001113 anchoring element; other site 1166016001114 dimer interface [polypeptide binding]; other site 1166016001115 ATP binding site [chemical binding]; other site 1166016001116 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1166016001117 active site 1166016001118 metal binding site [ion binding]; metal-binding site 1166016001119 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1166016001120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016001121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016001122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016001123 dimerization interface [polypeptide binding]; other site 1166016001124 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1166016001125 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1166016001126 intersubunit interface [polypeptide binding]; other site 1166016001127 active site 1166016001128 zinc binding site [ion binding]; other site 1166016001129 Na+ binding site [ion binding]; other site 1166016001130 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1166016001131 intersubunit interface [polypeptide binding]; other site 1166016001132 active site 1166016001133 zinc binding site [ion binding]; other site 1166016001134 Na+ binding site [ion binding]; other site 1166016001135 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1166016001136 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1166016001137 active site 1166016001138 P-loop; other site 1166016001139 phosphorylation site [posttranslational modification] 1166016001140 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016001141 active site 1166016001142 phosphorylation site [posttranslational modification] 1166016001143 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1166016001144 HTH domain; Region: HTH_11; pfam08279 1166016001145 Mga helix-turn-helix domain; Region: Mga; pfam05043 1166016001146 PRD domain; Region: PRD; pfam00874 1166016001147 PRD domain; Region: PRD; pfam00874 1166016001148 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1166016001149 active site 1166016001150 P-loop; other site 1166016001151 phosphorylation site [posttranslational modification] 1166016001152 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1166016001153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016001154 N-terminal plug; other site 1166016001155 ligand-binding site [chemical binding]; other site 1166016001156 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 1166016001157 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1166016001158 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1166016001159 CAP-like domain; other site 1166016001160 active site 1166016001161 primary dimer interface [polypeptide binding]; other site 1166016001162 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1166016001163 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1166016001164 putative acyl-acceptor binding pocket; other site 1166016001165 FtsI repressor; Provisional; Region: PRK10883 1166016001166 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1166016001167 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1166016001168 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1166016001169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016001170 DNA-binding site [nucleotide binding]; DNA binding site 1166016001171 UTRA domain; Region: UTRA; pfam07702 1166016001172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016001173 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016001174 active site 1166016001175 catalytic tetrad [active] 1166016001176 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016001177 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016001178 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016001179 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016001180 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1166016001181 PAAR motif; Region: PAAR_motif; pfam05488 1166016001182 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016001183 RHS Repeat; Region: RHS_repeat; pfam05593 1166016001184 RHS Repeat; Region: RHS_repeat; pfam05593 1166016001185 RHS Repeat; Region: RHS_repeat; pfam05593 1166016001186 RHS Repeat; Region: RHS_repeat; cl11982 1166016001187 RHS protein; Region: RHS; pfam03527 1166016001188 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001189 RHS protein; Region: RHS; pfam03527 1166016001190 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001191 RHS protein; Region: RHS; pfam03527 1166016001192 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001193 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016001194 RHS protein; Region: RHS; pfam03527 1166016001195 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001196 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1166016001197 RNAase interaction site [polypeptide binding]; other site 1166016001198 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1166016001199 active site 1166016001200 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1166016001201 RNAase interaction site [polypeptide binding]; other site 1166016001202 Homeodomain-like domain; Region: HTH_23; pfam13384 1166016001203 Winged helix-turn helix; Region: HTH_29; pfam13551 1166016001204 Homeodomain-like domain; Region: HTH_32; pfam13565 1166016001205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1166016001206 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1166016001207 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1166016001208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1166016001209 binding surface 1166016001210 TPR motif; other site 1166016001211 Transposase; Region: HTH_Tnp_1; pfam01527 1166016001212 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1166016001213 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1166016001214 dimer interface [polypeptide binding]; other site 1166016001215 active site 1166016001216 metal binding site [ion binding]; metal-binding site 1166016001217 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1166016001218 dimer interface [polypeptide binding]; other site 1166016001219 FMN binding site [chemical binding]; other site 1166016001220 NADPH bind site [chemical binding]; other site 1166016001221 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1166016001222 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166016001223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016001224 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1166016001225 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166016001226 cystathionine beta-lyase; Provisional; Region: PRK08114 1166016001227 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166016001228 homodimer interface [polypeptide binding]; other site 1166016001229 substrate-cofactor binding pocket; other site 1166016001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016001231 catalytic residue [active] 1166016001232 DctM-like transporters; Region: DctM; pfam06808 1166016001233 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1166016001234 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1166016001235 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1166016001236 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1166016001237 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1166016001238 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1166016001239 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1166016001240 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1166016001241 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1166016001242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016001243 DNA binding site [nucleotide binding] 1166016001244 domain linker motif; other site 1166016001245 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1166016001246 dimerization interface [polypeptide binding]; other site 1166016001247 ligand binding site [chemical binding]; other site 1166016001248 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1166016001249 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1166016001250 substrate binding [chemical binding]; other site 1166016001251 active site 1166016001252 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1166016001253 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1166016001254 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016001255 active site turn [active] 1166016001256 phosphorylation site [posttranslational modification] 1166016001257 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016001258 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166016001259 trimer interface; other site 1166016001260 sugar binding site [chemical binding]; other site 1166016001261 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016001262 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1166016001263 putative substrate binding site [chemical binding]; other site 1166016001264 putative ATP binding site [chemical binding]; other site 1166016001265 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1166016001266 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1166016001267 helicase Cas3; Provisional; Region: PRK09694 1166016001268 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1166016001269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016001270 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1166016001271 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1166016001272 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1166016001273 CT1975-like protein; Region: Cas_CT1975; pfam09344 1166016001274 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1166016001275 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1166016001276 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1166016001277 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1166016001278 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1166016001279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001280 salt bridge; other site 1166016001281 non-specific DNA binding site [nucleotide binding]; other site 1166016001282 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001283 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1166016001284 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1166016001285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001286 non-specific DNA binding site [nucleotide binding]; other site 1166016001287 salt bridge; other site 1166016001288 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001289 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 1166016001290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1166016001291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016001292 catalytic residue [active] 1166016001293 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166016001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016001295 putative substrate translocation pore; other site 1166016001296 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166016001297 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166016001298 hypothetical protein; Provisional; Region: PRK03467 1166016001299 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1166016001300 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1166016001301 NAD binding site [chemical binding]; other site 1166016001302 active site 1166016001303 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1166016001304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016001305 FeS/SAM binding site; other site 1166016001306 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1166016001307 ATP cone domain; Region: ATP-cone; pfam03477 1166016001308 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1166016001309 effector binding site; other site 1166016001310 active site 1166016001311 Zn binding site [ion binding]; other site 1166016001312 glycine loop; other site 1166016001313 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1166016001314 homotrimer interaction site [polypeptide binding]; other site 1166016001315 putative active site [active] 1166016001316 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1166016001317 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1166016001318 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1166016001319 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1166016001320 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1166016001321 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1166016001322 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1166016001323 PAS fold; Region: PAS_4; pfam08448 1166016001324 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166016001325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016001326 DNA binding residues [nucleotide binding] 1166016001327 dimerization interface [polypeptide binding]; other site 1166016001328 PAS fold; Region: PAS_4; pfam08448 1166016001329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016001330 DNA binding residues [nucleotide binding] 1166016001331 dimerization interface [polypeptide binding]; other site 1166016001332 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1166016001333 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1166016001334 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1166016001335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1166016001336 RNase E inhibitor protein; Provisional; Region: PRK11191 1166016001337 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166016001338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016001339 Coenzyme A binding pocket [chemical binding]; other site 1166016001340 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1166016001341 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1166016001342 hypothetical protein; Provisional; Region: PRK06489 1166016001343 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1166016001344 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1166016001345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016001346 dimerization interface [polypeptide binding]; other site 1166016001347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016001348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016001349 dimer interface [polypeptide binding]; other site 1166016001350 putative CheW interface [polypeptide binding]; other site 1166016001351 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1166016001352 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1166016001353 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1166016001354 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1166016001355 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1166016001356 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1166016001357 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1166016001358 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1166016001359 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1166016001360 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1166016001361 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1166016001362 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 1166016001363 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1166016001364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016001365 Q-loop/lid; other site 1166016001366 ABC transporter signature motif; other site 1166016001367 Walker B; other site 1166016001368 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166016001369 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1166016001370 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1166016001371 HIGH motif; other site 1166016001372 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1166016001373 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1166016001374 active site 1166016001375 KMSKS motif; other site 1166016001376 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1166016001377 tRNA binding surface [nucleotide binding]; other site 1166016001378 anticodon binding site; other site 1166016001379 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1166016001380 DNA polymerase III subunit chi; Validated; Region: PRK05728 1166016001381 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1166016001382 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1166016001383 interface (dimer of trimers) [polypeptide binding]; other site 1166016001384 Substrate-binding/catalytic site; other site 1166016001385 Zn-binding sites [ion binding]; other site 1166016001386 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1166016001387 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1166016001388 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1166016001389 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1166016001390 integrase; Provisional; Region: PRK09692 1166016001391 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016001392 active site 1166016001393 Int/Topo IB signature motif; other site 1166016001394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001395 non-specific DNA binding site [nucleotide binding]; other site 1166016001396 salt bridge; other site 1166016001397 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001398 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1166016001399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1166016001400 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1166016001401 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1166016001402 active site 1166016001403 metal binding site [ion binding]; metal-binding site 1166016001404 AAA domain; Region: AAA_25; pfam13481 1166016001405 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1166016001406 Walker B motif; other site 1166016001407 Ash protein family; Region: Phage_ASH; pfam10554 1166016001408 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166016001409 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1166016001410 Integrase; Region: Integrase_1; pfam12835 1166016001411 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1166016001412 Predicted transcriptional regulator [Transcription]; Region: COG2944 1166016001413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001414 non-specific DNA binding site [nucleotide binding]; other site 1166016001415 salt bridge; other site 1166016001416 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016001418 ATP binding site [chemical binding]; other site 1166016001419 Mg2+ binding site [ion binding]; other site 1166016001420 G-X-G motif; other site 1166016001421 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1166016001422 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016001423 active site 1166016001424 Int/Topo IB signature motif; other site 1166016001425 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1166016001426 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1166016001427 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1166016001428 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1166016001429 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1166016001430 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1166016001431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016001432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016001433 ATP binding site [chemical binding]; other site 1166016001434 putative Mg++ binding site [ion binding]; other site 1166016001435 Virulence protein [General function prediction only]; Region: COG3943 1166016001436 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1166016001437 PAAR motif; Region: PAAR_motif; pfam05488 1166016001438 PAAR motif; Region: PAAR_motif; pfam05488 1166016001439 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1166016001440 Vps5 C terminal like; Region: Vps5; pfam09325 1166016001441 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1166016001442 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1166016001443 FtsX-like permease family; Region: FtsX; pfam02687 1166016001444 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166016001445 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1166016001446 Walker A/P-loop; other site 1166016001447 ATP binding site [chemical binding]; other site 1166016001448 Q-loop/lid; other site 1166016001449 ABC transporter signature motif; other site 1166016001450 Walker B; other site 1166016001451 D-loop; other site 1166016001452 H-loop/switch region; other site 1166016001453 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1166016001454 metal ion-dependent adhesion site (MIDAS); other site 1166016001455 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1166016001456 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1166016001457 Virulence factor SrfB; Region: SrfB; pfam07520 1166016001458 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1166016001459 metal ion-dependent adhesion site (MIDAS); other site 1166016001460 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1166016001461 Secretory lipase; Region: LIP; pfam03583 1166016001462 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166016001463 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1166016001464 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1166016001465 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1166016001466 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1166016001467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016001468 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016001469 Outer membrane efflux protein; Region: OEP; pfam02321 1166016001470 Outer membrane efflux protein; Region: OEP; pfam02321 1166016001471 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166016001472 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1166016001473 Walker A/P-loop; other site 1166016001474 ATP binding site [chemical binding]; other site 1166016001475 Q-loop/lid; other site 1166016001476 ABC transporter signature motif; other site 1166016001477 Walker B; other site 1166016001478 D-loop; other site 1166016001479 H-loop/switch region; other site 1166016001480 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1166016001481 Aspartase; Region: Aspartase; cd01357 1166016001482 active sites [active] 1166016001483 tetramer interface [polypeptide binding]; other site 1166016001484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016001485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016001486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016001487 dimerization interface [polypeptide binding]; other site 1166016001488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001489 non-specific DNA binding site [nucleotide binding]; other site 1166016001490 salt bridge; other site 1166016001491 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001492 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1166016001493 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1166016001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016001495 Walker A motif; other site 1166016001496 ATP binding site [chemical binding]; other site 1166016001497 Walker B motif; other site 1166016001498 arginine finger; other site 1166016001499 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1166016001500 hypothetical protein; Reviewed; Region: PRK09588 1166016001501 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1166016001502 HNH endonuclease; Region: HNH_2; pfam13391 1166016001503 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1166016001504 Nitrate and nitrite sensing; Region: NIT; pfam08376 1166016001505 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016001506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1166016001507 dimerization interface [polypeptide binding]; other site 1166016001508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016001509 dimer interface [polypeptide binding]; other site 1166016001510 putative CheW interface [polypeptide binding]; other site 1166016001511 magnesium-transporting ATPase; Provisional; Region: PRK15122 1166016001512 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1166016001513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166016001514 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1166016001515 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1166016001516 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1166016001517 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1166016001518 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016001519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016001520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016001521 dimer interface [polypeptide binding]; other site 1166016001522 putative CheW interface [polypeptide binding]; other site 1166016001523 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1166016001524 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1166016001525 intersubunit interface [polypeptide binding]; other site 1166016001526 active site 1166016001527 Zn2+ binding site [ion binding]; other site 1166016001528 L-rhamnose isomerase; Provisional; Region: PRK01076 1166016001529 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1166016001530 N- and C-terminal domain interface [polypeptide binding]; other site 1166016001531 active site 1166016001532 putative catalytic site [active] 1166016001533 metal binding site [ion binding]; metal-binding site 1166016001534 ATP binding site [chemical binding]; other site 1166016001535 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1166016001536 carbohydrate binding site [chemical binding]; other site 1166016001537 transcriptional activator RhaS; Provisional; Region: PRK13503 1166016001538 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016001539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016001540 transcriptional activator RhaR; Provisional; Region: PRK13501 1166016001541 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016001542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016001543 Predicted transcriptional regulator [Transcription]; Region: COG3905 1166016001544 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1166016001545 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1166016001546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016001547 Walker A/P-loop; other site 1166016001548 ATP binding site [chemical binding]; other site 1166016001549 Q-loop/lid; other site 1166016001550 ABC transporter signature motif; other site 1166016001551 Walker B; other site 1166016001552 D-loop; other site 1166016001553 H-loop/switch region; other site 1166016001554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016001555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016001556 Walker A/P-loop; other site 1166016001557 ATP binding site [chemical binding]; other site 1166016001558 Q-loop/lid; other site 1166016001559 ABC transporter signature motif; other site 1166016001560 Walker B; other site 1166016001561 D-loop; other site 1166016001562 H-loop/switch region; other site 1166016001563 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016001564 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1166016001565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016001566 dimer interface [polypeptide binding]; other site 1166016001567 conserved gate region; other site 1166016001568 putative PBP binding loops; other site 1166016001569 ABC-ATPase subunit interface; other site 1166016001570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166016001571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016001572 dimer interface [polypeptide binding]; other site 1166016001573 conserved gate region; other site 1166016001574 putative PBP binding loops; other site 1166016001575 ABC-ATPase subunit interface; other site 1166016001576 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166016001577 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1166016001578 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 1166016001579 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1166016001580 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1166016001581 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1166016001582 hypothetical protein; Provisional; Region: PRK05208 1166016001583 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1166016001584 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1166016001585 NAD(P) binding site [chemical binding]; other site 1166016001586 substrate binding site [chemical binding]; other site 1166016001587 dimer interface [polypeptide binding]; other site 1166016001588 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 1166016001589 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001590 RHS protein; Region: RHS; pfam03527 1166016001591 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001592 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016001593 PAAR motif; Region: PAAR_motif; pfam05488 1166016001594 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016001595 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 1166016001596 oxidoreductase; Provisional; Region: PRK08013 1166016001597 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1166016001598 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1166016001599 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1166016001600 proline aminopeptidase P II; Provisional; Region: PRK10879 1166016001601 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1166016001602 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1166016001603 active site 1166016001604 hypothetical protein; Reviewed; Region: PRK01736 1166016001605 Z-ring-associated protein; Provisional; Region: PRK10972 1166016001606 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1166016001607 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1166016001608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001609 non-specific DNA binding site [nucleotide binding]; other site 1166016001610 salt bridge; other site 1166016001611 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1166016001612 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001613 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1166016001614 active site 1166016001615 (T/H)XGH motif; other site 1166016001616 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1166016001617 DNA repair protein RadA; Region: sms; TIGR00416 1166016001618 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1166016001619 Walker A motif/ATP binding site; other site 1166016001620 ATP binding site [chemical binding]; other site 1166016001621 Walker B motif; other site 1166016001622 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1166016001623 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1166016001624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016001625 motif I; other site 1166016001626 motif II; other site 1166016001627 hypothetical protein; Provisional; Region: PRK11246 1166016001628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016001629 non-specific DNA binding site [nucleotide binding]; other site 1166016001630 salt bridge; other site 1166016001631 sequence-specific DNA binding site [nucleotide binding]; other site 1166016001632 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1166016001633 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1166016001634 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1166016001635 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1166016001636 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1166016001637 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1166016001638 G1 box; other site 1166016001639 putative GEF interaction site [polypeptide binding]; other site 1166016001640 GTP/Mg2+ binding site [chemical binding]; other site 1166016001641 Switch I region; other site 1166016001642 G2 box; other site 1166016001643 G3 box; other site 1166016001644 Switch II region; other site 1166016001645 G4 box; other site 1166016001646 G5 box; other site 1166016001647 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1166016001648 periplasmic protein; Provisional; Region: PRK10568 1166016001649 BON domain; Region: BON; pfam04972 1166016001650 BON domain; Region: BON; pfam04972 1166016001651 CsbD-like; Region: CsbD; cl17424 1166016001652 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1166016001653 active site 1166016001654 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1166016001655 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1166016001656 Nucleoside recognition; Region: Gate; pfam07670 1166016001657 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1166016001658 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1166016001659 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1166016001660 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016001661 ligand-binding site [chemical binding]; other site 1166016001662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016001663 N-terminal plug; other site 1166016001664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1166016001665 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1166016001666 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1166016001667 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1166016001668 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1166016001669 acyl-activating enzyme (AAE) consensus motif; other site 1166016001670 active site 1166016001671 AMP binding site [chemical binding]; other site 1166016001672 substrate binding site [chemical binding]; other site 1166016001673 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1166016001674 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1166016001675 putative NAD(P) binding site [chemical binding]; other site 1166016001676 active site 1166016001677 Outer membrane efflux protein; Region: OEP; pfam02321 1166016001678 Outer membrane efflux protein; Region: OEP; pfam02321 1166016001679 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1166016001680 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001681 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001682 Ca2+ binding site [ion binding]; other site 1166016001683 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001684 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001685 Ca2+ binding site [ion binding]; other site 1166016001686 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001687 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001688 Ca2+ binding site [ion binding]; other site 1166016001689 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001690 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001691 Ca2+ binding site [ion binding]; other site 1166016001692 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001693 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001694 Ca2+ binding site [ion binding]; other site 1166016001695 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001696 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001697 Ca2+ binding site [ion binding]; other site 1166016001698 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001699 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001700 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001701 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001702 Ca2+ binding site [ion binding]; other site 1166016001703 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001704 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001705 Ca2+ binding site [ion binding]; other site 1166016001706 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001707 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001708 Ca2+ binding site [ion binding]; other site 1166016001709 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001710 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001711 Ca2+ binding site [ion binding]; other site 1166016001712 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016001713 Cadherin repeat-like domain; Region: CA_like; cl15786 1166016001714 Ca2+ binding site [ion binding]; other site 1166016001715 Phage Tail Collar Domain; Region: Collar; pfam07484 1166016001716 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1166016001717 active site 1166016001718 putative substrate binding region [chemical binding]; other site 1166016001719 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166016001720 carboxyltransferase (CT) interaction site; other site 1166016001721 biotinylation site [posttranslational modification]; other site 1166016001722 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016001723 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016001724 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016001725 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016001726 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016001727 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 1166016001728 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1166016001729 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1166016001730 tetramer interface [polypeptide binding]; other site 1166016001731 active site 1166016001732 Mg2+/Mn2+ binding site [ion binding]; other site 1166016001733 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166016001734 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 1166016001735 PYR/PP interface [polypeptide binding]; other site 1166016001736 dimer interface [polypeptide binding]; other site 1166016001737 TPP binding site [chemical binding]; other site 1166016001738 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 1166016001739 TPP-binding site; other site 1166016001740 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1166016001741 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1166016001742 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1166016001743 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1166016001744 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 1166016001745 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1166016001746 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016001747 Walker A/P-loop; other site 1166016001748 ATP binding site [chemical binding]; other site 1166016001749 Q-loop/lid; other site 1166016001750 ABC transporter signature motif; other site 1166016001751 Walker B; other site 1166016001752 D-loop; other site 1166016001753 H-loop/switch region; other site 1166016001754 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016001755 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1166016001756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016001757 Walker A/P-loop; other site 1166016001758 ATP binding site [chemical binding]; other site 1166016001759 Q-loop/lid; other site 1166016001760 ABC transporter signature motif; other site 1166016001761 Walker B; other site 1166016001762 D-loop; other site 1166016001763 H-loop/switch region; other site 1166016001764 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1166016001765 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1166016001766 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1166016001767 active site 1166016001768 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1166016001769 Guanylate kinase; Region: Guanylate_kin; pfam00625 1166016001770 active site 1166016001771 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1166016001772 putative hydrolase; Provisional; Region: PRK02113 1166016001773 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1166016001774 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1166016001775 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1166016001776 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1166016001777 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1166016001778 SLBB domain; Region: SLBB; pfam10531 1166016001779 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1166016001780 Chain length determinant protein; Region: Wzz; pfam02706 1166016001781 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1166016001782 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1166016001783 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1166016001784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166016001785 active site 1166016001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166016001787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166016001788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166016001789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166016001790 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1166016001791 putative acyl transferase; Provisional; Region: PRK10191 1166016001792 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1166016001793 trimer interface [polypeptide binding]; other site 1166016001794 active site 1166016001795 substrate binding site [chemical binding]; other site 1166016001796 CoA binding site [chemical binding]; other site 1166016001797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1166016001798 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 1166016001799 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016001800 Helix-turn-helix domain; Region: HTH_18; pfam12833 1166016001801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016001802 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166016001803 putative transcriptional regulator; Provisional; Region: PRK11640 1166016001804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016001805 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1166016001806 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1166016001807 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1166016001808 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1166016001809 DsbD alpha interface [polypeptide binding]; other site 1166016001810 catalytic residues [active] 1166016001811 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1166016001812 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1166016001813 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1166016001814 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1166016001815 Aspartase; Region: Aspartase; cd01357 1166016001816 active sites [active] 1166016001817 tetramer interface [polypeptide binding]; other site 1166016001818 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1166016001819 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1166016001820 oligomerisation interface [polypeptide binding]; other site 1166016001821 mobile loop; other site 1166016001822 roof hairpin; other site 1166016001823 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1166016001824 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1166016001825 ring oligomerisation interface [polypeptide binding]; other site 1166016001826 ATP/Mg binding site [chemical binding]; other site 1166016001827 stacking interactions; other site 1166016001828 hinge regions; other site 1166016001829 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1166016001830 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1166016001831 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166016001832 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1166016001833 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1166016001834 putative acyl-acceptor binding pocket; other site 1166016001835 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1166016001836 LexA repressor; Validated; Region: PRK00215 1166016001837 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1166016001838 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1166016001839 Catalytic site [active] 1166016001840 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1166016001841 metal binding site 2 [ion binding]; metal-binding site 1166016001842 putative DNA binding helix; other site 1166016001843 metal binding site 1 [ion binding]; metal-binding site 1166016001844 dimer interface [polypeptide binding]; other site 1166016001845 structural Zn2+ binding site [ion binding]; other site 1166016001846 Pirin-related protein [General function prediction only]; Region: COG1741 1166016001847 Pirin; Region: Pirin; pfam02678 1166016001848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016001849 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1166016001850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016001851 dimerization interface [polypeptide binding]; other site 1166016001852 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1166016001853 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1166016001854 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1166016001855 putative dimer interface [polypeptide binding]; other site 1166016001856 N-terminal domain interface [polypeptide binding]; other site 1166016001857 putative substrate binding pocket (H-site) [chemical binding]; other site 1166016001858 Predicted membrane protein [Function unknown]; Region: COG2259 1166016001859 YqjK-like protein; Region: YqjK; pfam13997 1166016001860 Predicted membrane protein [Function unknown]; Region: COG5393 1166016001861 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1166016001862 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1166016001863 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166016001864 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1166016001865 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1166016001866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016001867 DNA-binding site [nucleotide binding]; DNA binding site 1166016001868 FCD domain; Region: FCD; pfam07729 1166016001869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016001870 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016001871 putative substrate translocation pore; other site 1166016001872 Glucuronate isomerase; Region: UxaC; pfam02614 1166016001873 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1166016001874 altronate oxidoreductase; Provisional; Region: PRK03643 1166016001875 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166016001876 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166016001877 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1166016001878 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1166016001879 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1166016001880 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1166016001881 serine/threonine transporter SstT; Provisional; Region: PRK13628 1166016001882 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166016001883 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1166016001884 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016001885 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016001886 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1166016001887 Methyltransferase small domain; Region: MTS; pfam05175 1166016001888 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166016001889 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1166016001890 active site 1166016001891 FMN binding site [chemical binding]; other site 1166016001892 2,4-decadienoyl-CoA binding site; other site 1166016001893 catalytic residue [active] 1166016001894 4Fe-4S cluster binding site [ion binding]; other site 1166016001895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1166016001896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016001897 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1166016001898 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1166016001899 dimer interface [polypeptide binding]; other site 1166016001900 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016001901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016001902 metal binding site [ion binding]; metal-binding site 1166016001903 active site 1166016001904 I-site; other site 1166016001905 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1166016001906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016001907 active site turn [active] 1166016001908 phosphorylation site [posttranslational modification] 1166016001909 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016001910 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1166016001911 HPr interaction site; other site 1166016001912 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166016001913 active site 1166016001914 phosphorylation site [posttranslational modification] 1166016001915 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1166016001916 CAT RNA binding domain; Region: CAT_RBD; smart01061 1166016001917 PRD domain; Region: PRD; pfam00874 1166016001918 PRD domain; Region: PRD; pfam00874 1166016001919 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166016001920 trimer interface; other site 1166016001921 sugar binding site [chemical binding]; other site 1166016001922 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 1166016001923 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1166016001924 Sulfatase; Region: Sulfatase; cl17466 1166016001925 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1166016001926 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1166016001927 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016001928 FeS/SAM binding site; other site 1166016001929 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1166016001930 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1166016001931 Sulfatase; Region: Sulfatase; pfam00884 1166016001932 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1166016001933 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1166016001934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016001935 motif II; other site 1166016001936 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1166016001937 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1166016001938 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1166016001939 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1166016001940 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 1166016001941 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016001942 active site turn [active] 1166016001943 phosphorylation site [posttranslational modification] 1166016001944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016001945 trehalose repressor; Provisional; Region: treR; PRK09492 1166016001946 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016001947 DNA binding site [nucleotide binding] 1166016001948 domain linker motif; other site 1166016001949 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1166016001950 dimerization interface [polypeptide binding]; other site 1166016001951 ligand binding site [chemical binding]; other site 1166016001952 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166016001953 beta-galactosidase; Region: BGL; TIGR03356 1166016001954 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1166016001955 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1166016001956 molybdopterin cofactor binding site; other site 1166016001957 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1166016001958 molybdopterin cofactor binding site; other site 1166016001959 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1166016001960 Flavodoxin; Region: Flavodoxin_1; pfam00258 1166016001961 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1166016001962 FAD binding pocket [chemical binding]; other site 1166016001963 FAD binding motif [chemical binding]; other site 1166016001964 catalytic residues [active] 1166016001965 NAD binding pocket [chemical binding]; other site 1166016001966 phosphate binding motif [ion binding]; other site 1166016001967 beta-alpha-beta structure motif; other site 1166016001968 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1166016001969 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1166016001970 potential catalytic triad [active] 1166016001971 conserved cys residue [active] 1166016001972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016001973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016001974 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166016001975 putative effector binding pocket; other site 1166016001976 putative dimerization interface [polypeptide binding]; other site 1166016001977 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1166016001978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016001979 DNA-binding site [nucleotide binding]; DNA binding site 1166016001980 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1166016001981 transketolase; Reviewed; Region: PRK12753 1166016001982 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166016001983 TPP-binding site [chemical binding]; other site 1166016001984 dimer interface [polypeptide binding]; other site 1166016001985 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166016001986 PYR/PP interface [polypeptide binding]; other site 1166016001987 dimer interface [polypeptide binding]; other site 1166016001988 TPP binding site [chemical binding]; other site 1166016001989 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166016001990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016001991 active site 1166016001992 phosphorylation site [posttranslational modification] 1166016001993 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1166016001994 active site 1166016001995 P-loop; other site 1166016001996 phosphorylation site [posttranslational modification] 1166016001997 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1166016001998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166016001999 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1166016002000 active site 1166016002001 SUMO-1 interface [polypeptide binding]; other site 1166016002002 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1166016002003 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1166016002004 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1166016002005 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1166016002006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016002007 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166016002008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016002009 DNA binding residues [nucleotide binding] 1166016002010 DNA primase; Validated; Region: dnaG; PRK05667 1166016002011 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1166016002012 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1166016002013 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1166016002014 active site 1166016002015 metal binding site [ion binding]; metal-binding site 1166016002016 interdomain interaction site; other site 1166016002017 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1166016002018 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1166016002019 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1166016002020 UGMP family protein; Validated; Region: PRK09604 1166016002021 arginine repressor; Provisional; Region: PRK05066 1166016002022 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1166016002023 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1166016002024 malate dehydrogenase; Provisional; Region: PRK05086 1166016002025 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1166016002026 NAD binding site [chemical binding]; other site 1166016002027 dimerization interface [polypeptide binding]; other site 1166016002028 Substrate binding site [chemical binding]; other site 1166016002029 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1166016002030 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1166016002031 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1166016002032 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1166016002033 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1166016002034 substrate binding pocket [chemical binding]; other site 1166016002035 chain length determination region; other site 1166016002036 substrate-Mg2+ binding site; other site 1166016002037 catalytic residues [active] 1166016002038 aspartate-rich region 1; other site 1166016002039 active site lid residues [active] 1166016002040 aspartate-rich region 2; other site 1166016002041 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1166016002042 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1166016002043 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1166016002044 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166016002045 EamA-like transporter family; Region: EamA; pfam00892 1166016002046 EamA-like transporter family; Region: EamA; pfam00892 1166016002047 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1166016002048 GTP1/OBG; Region: GTP1_OBG; pfam01018 1166016002049 Obg GTPase; Region: Obg; cd01898 1166016002050 G1 box; other site 1166016002051 GTP/Mg2+ binding site [chemical binding]; other site 1166016002052 Switch I region; other site 1166016002053 G2 box; other site 1166016002054 G3 box; other site 1166016002055 Switch II region; other site 1166016002056 G4 box; other site 1166016002057 G5 box; other site 1166016002058 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1166016002059 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1166016002060 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1166016002061 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1166016002062 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1166016002063 RNA-binding protein YhbY; Provisional; Region: PRK10343 1166016002064 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1166016002065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016002066 S-adenosylmethionine binding site [chemical binding]; other site 1166016002067 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1166016002068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016002069 Walker A motif; other site 1166016002070 ATP binding site [chemical binding]; other site 1166016002071 Walker B motif; other site 1166016002072 arginine finger; other site 1166016002073 Peptidase family M41; Region: Peptidase_M41; pfam01434 1166016002074 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1166016002075 dihydropteroate synthase; Region: DHPS; TIGR01496 1166016002076 substrate binding pocket [chemical binding]; other site 1166016002077 dimer interface [polypeptide binding]; other site 1166016002078 inhibitor binding site; inhibition site 1166016002079 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1166016002080 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1166016002081 active site 1166016002082 substrate binding site [chemical binding]; other site 1166016002083 metal binding site [ion binding]; metal-binding site 1166016002084 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1166016002085 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1166016002086 Sm and related proteins; Region: Sm_like; cl00259 1166016002087 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1166016002088 putative oligomer interface [polypeptide binding]; other site 1166016002089 putative RNA binding site [nucleotide binding]; other site 1166016002090 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1166016002091 NusA N-terminal domain; Region: NusA_N; pfam08529 1166016002092 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1166016002093 RNA binding site [nucleotide binding]; other site 1166016002094 homodimer interface [polypeptide binding]; other site 1166016002095 NusA-like KH domain; Region: KH_5; pfam13184 1166016002096 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1166016002097 G-X-X-G motif; other site 1166016002098 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1166016002099 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1166016002100 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1166016002101 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1166016002102 translation initiation factor IF-2; Region: IF-2; TIGR00487 1166016002103 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1166016002104 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1166016002105 G1 box; other site 1166016002106 putative GEF interaction site [polypeptide binding]; other site 1166016002107 GTP/Mg2+ binding site [chemical binding]; other site 1166016002108 Switch I region; other site 1166016002109 G2 box; other site 1166016002110 G3 box; other site 1166016002111 Switch II region; other site 1166016002112 G4 box; other site 1166016002113 G5 box; other site 1166016002114 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1166016002115 Translation-initiation factor 2; Region: IF-2; pfam11987 1166016002116 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1166016002117 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1166016002118 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1166016002119 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1166016002120 RNA binding site [nucleotide binding]; other site 1166016002121 active site 1166016002122 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1166016002123 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1166016002124 16S/18S rRNA binding site [nucleotide binding]; other site 1166016002125 S13e-L30e interaction site [polypeptide binding]; other site 1166016002126 25S rRNA binding site [nucleotide binding]; other site 1166016002127 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1166016002128 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1166016002129 RNase E interface [polypeptide binding]; other site 1166016002130 trimer interface [polypeptide binding]; other site 1166016002131 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1166016002132 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1166016002133 RNase E interface [polypeptide binding]; other site 1166016002134 trimer interface [polypeptide binding]; other site 1166016002135 active site 1166016002136 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1166016002137 putative nucleic acid binding region [nucleotide binding]; other site 1166016002138 G-X-X-G motif; other site 1166016002139 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1166016002140 RNA binding site [nucleotide binding]; other site 1166016002141 domain interface; other site 1166016002142 lipoprotein NlpI; Provisional; Region: PRK11189 1166016002143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016002144 binding surface 1166016002145 TPR motif; other site 1166016002146 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166016002147 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1166016002148 ATP binding site [chemical binding]; other site 1166016002149 Mg++ binding site [ion binding]; other site 1166016002150 motif III; other site 1166016002151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016002152 nucleotide binding region [chemical binding]; other site 1166016002153 ATP-binding site [chemical binding]; other site 1166016002154 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1166016002155 putative RNA binding site [nucleotide binding]; other site 1166016002156 hypothetical protein; Provisional; Region: PRK10508 1166016002157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1166016002158 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1166016002159 putative protease; Provisional; Region: PRK15447 1166016002160 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1166016002161 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1166016002162 Peptidase family U32; Region: Peptidase_U32; pfam01136 1166016002163 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1166016002164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016002165 Coenzyme A binding pocket [chemical binding]; other site 1166016002166 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1166016002167 GIY-YIG motif/motif A; other site 1166016002168 putative active site [active] 1166016002169 putative metal binding site [ion binding]; other site 1166016002170 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1166016002171 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1166016002172 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1166016002173 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1166016002174 phosphopentomutase; Provisional; Region: PRK05362 1166016002175 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1166016002176 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1166016002177 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1166016002178 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166016002179 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016002180 N-terminal plug; other site 1166016002181 ligand-binding site [chemical binding]; other site 1166016002182 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1166016002183 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1166016002184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016002185 Coenzyme A binding pocket [chemical binding]; other site 1166016002186 DNA polymerase III subunit psi; Validated; Region: PRK06856 1166016002187 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1166016002188 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1166016002189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016002190 S-adenosylmethionine binding site [chemical binding]; other site 1166016002191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016002192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016002193 active site 1166016002194 catalytic tetrad [active] 1166016002195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016002196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016002197 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1166016002198 putative effector binding pocket; other site 1166016002199 putative dimerization interface [polypeptide binding]; other site 1166016002200 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1166016002201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016002202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016002203 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1166016002204 putative dimerization interface [polypeptide binding]; other site 1166016002205 putative substrate binding pocket [chemical binding]; other site 1166016002206 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1166016002207 acetolactate synthase; Reviewed; Region: PRK08617 1166016002208 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166016002209 PYR/PP interface [polypeptide binding]; other site 1166016002210 dimer interface [polypeptide binding]; other site 1166016002211 TPP binding site [chemical binding]; other site 1166016002212 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166016002213 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1166016002214 TPP-binding site [chemical binding]; other site 1166016002215 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1166016002216 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1166016002217 dimer interface [polypeptide binding]; other site 1166016002218 active site 1166016002219 metal binding site [ion binding]; metal-binding site 1166016002220 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1166016002221 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1166016002222 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1166016002223 lipoyl attachment site [posttranslational modification]; other site 1166016002224 glycine dehydrogenase; Provisional; Region: PRK05367 1166016002225 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1166016002226 tetramer interface [polypeptide binding]; other site 1166016002227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016002228 catalytic residue [active] 1166016002229 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1166016002230 tetramer interface [polypeptide binding]; other site 1166016002231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016002232 catalytic residue [active] 1166016002233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002234 dimer interface [polypeptide binding]; other site 1166016002235 conserved gate region; other site 1166016002236 putative PBP binding loops; other site 1166016002237 ABC-ATPase subunit interface; other site 1166016002238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166016002239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002240 dimer interface [polypeptide binding]; other site 1166016002241 conserved gate region; other site 1166016002242 putative PBP binding loops; other site 1166016002243 ABC-ATPase subunit interface; other site 1166016002244 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1166016002245 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166016002246 active site 1166016002247 metal binding site [ion binding]; metal-binding site 1166016002248 hexamer interface [polypeptide binding]; other site 1166016002249 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1166016002250 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166016002251 Walker A/P-loop; other site 1166016002252 ATP binding site [chemical binding]; other site 1166016002253 Q-loop/lid; other site 1166016002254 ABC transporter signature motif; other site 1166016002255 Walker B; other site 1166016002256 D-loop; other site 1166016002257 H-loop/switch region; other site 1166016002258 TOBE domain; Region: TOBE_2; pfam08402 1166016002259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166016002260 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1166016002261 galactoside permease; Reviewed; Region: lacY; PRK09528 1166016002262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002263 putative substrate translocation pore; other site 1166016002264 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1166016002265 Melibiase; Region: Melibiase; pfam02065 1166016002266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016002267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016002268 DNA binding site [nucleotide binding] 1166016002269 domain linker motif; other site 1166016002270 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1166016002271 ligand binding site [chemical binding]; other site 1166016002272 HD domain; Region: HD_3; pfam13023 1166016002273 hemolysin; Provisional; Region: PRK15087 1166016002274 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1166016002275 putative global regulator; Reviewed; Region: PRK09559 1166016002276 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1166016002277 hypothetical protein; Provisional; Region: PRK10878 1166016002278 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1166016002279 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1166016002280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016002281 S-adenosylmethionine binding site [chemical binding]; other site 1166016002282 flavodoxin FldB; Provisional; Region: PRK12359 1166016002283 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1166016002284 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166016002285 Walker A/P-loop; other site 1166016002286 ATP binding site [chemical binding]; other site 1166016002287 Q-loop/lid; other site 1166016002288 ABC transporter signature motif; other site 1166016002289 Walker B; other site 1166016002290 D-loop; other site 1166016002291 H-loop/switch region; other site 1166016002292 NIL domain; Region: NIL; pfam09383 1166016002293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002294 dimer interface [polypeptide binding]; other site 1166016002295 conserved gate region; other site 1166016002296 putative PBP binding loops; other site 1166016002297 ABC-ATPase subunit interface; other site 1166016002298 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1166016002299 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1166016002300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002301 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166016002302 putative substrate translocation pore; other site 1166016002303 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1166016002304 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1166016002305 active site 1166016002306 Int/Topo IB signature motif; other site 1166016002307 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1166016002308 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1166016002309 dimerization domain [polypeptide binding]; other site 1166016002310 dimer interface [polypeptide binding]; other site 1166016002311 catalytic residues [active] 1166016002312 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1166016002313 DHH family; Region: DHH; pfam01368 1166016002314 DHHA1 domain; Region: DHHA1; pfam02272 1166016002315 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1166016002316 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1166016002317 RF-1 domain; Region: RF-1; pfam00472 1166016002318 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1166016002319 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1166016002320 dimer interface [polypeptide binding]; other site 1166016002321 putative anticodon binding site; other site 1166016002322 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1166016002323 motif 1; other site 1166016002324 active site 1166016002325 motif 2; other site 1166016002326 motif 3; other site 1166016002327 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016002328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016002329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016002330 LysE type translocator; Region: LysE; cl00565 1166016002331 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1166016002332 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1166016002333 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166016002334 putative acyl-acceptor binding pocket; other site 1166016002335 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1166016002336 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1166016002337 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1166016002338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166016002339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016002340 active site 1166016002341 phosphorylation site [posttranslational modification] 1166016002342 intermolecular recognition site; other site 1166016002343 dimerization interface [polypeptide binding]; other site 1166016002344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016002345 DNA binding site [nucleotide binding] 1166016002346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1166016002347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1166016002348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016002349 dimer interface [polypeptide binding]; other site 1166016002350 phosphorylation site [posttranslational modification] 1166016002351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016002352 ATP binding site [chemical binding]; other site 1166016002353 Mg2+ binding site [ion binding]; other site 1166016002354 G-X-G motif; other site 1166016002355 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1166016002356 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 1166016002357 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1166016002358 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1166016002359 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016002360 pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522 1166016002361 Type IV pili component [Cell motility and secretion]; Region: COG5461 1166016002362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1166016002363 active site 1166016002364 phosphorylation site [posttranslational modification] 1166016002365 dimerization interface [polypeptide binding]; other site 1166016002366 AAA domain; Region: AAA_31; pfam13614 1166016002367 Type II/IV secretion system protein; Region: T2SE; pfam00437 1166016002368 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1166016002369 ATP binding site [chemical binding]; other site 1166016002370 Walker A motif; other site 1166016002371 hexamer interface [polypeptide binding]; other site 1166016002372 Walker B motif; other site 1166016002373 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1166016002374 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016002375 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1166016002376 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016002377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016002378 binding surface 1166016002379 TPR motif; other site 1166016002380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1166016002381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016002382 binding surface 1166016002383 TPR motif; other site 1166016002384 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1166016002385 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1166016002386 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1166016002387 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1166016002388 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1166016002389 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016002390 Putative Ig domain; Region: He_PIG; pfam05345 1166016002391 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1166016002392 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1166016002393 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1166016002394 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1166016002395 Putative Ig domain; Region: He_PIG; pfam05345 1166016002396 Outer membrane efflux protein; Region: OEP; pfam02321 1166016002397 Outer membrane efflux protein; Region: OEP; pfam02321 1166016002398 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016002399 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016002400 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166016002401 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016002402 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1166016002403 active site 1166016002404 putative substrate binding region [chemical binding]; other site 1166016002405 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016002406 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016002407 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 1166016002408 active site 1166016002409 catalytic site [active] 1166016002410 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 1166016002411 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 1166016002412 Ca binding site [ion binding]; other site 1166016002413 substrate binding site [chemical binding]; other site 1166016002414 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1166016002415 putative transposase; Provisional; Region: PRK09857 1166016002416 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1166016002417 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1166016002418 Na binding site [ion binding]; other site 1166016002419 Predicted membrane protein [Function unknown]; Region: COG3162 1166016002420 acetyl-CoA synthetase; Provisional; Region: PRK00174 1166016002421 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1166016002422 active site 1166016002423 CoA binding site [chemical binding]; other site 1166016002424 acyl-activating enzyme (AAE) consensus motif; other site 1166016002425 AMP binding site [chemical binding]; other site 1166016002426 acetate binding site [chemical binding]; other site 1166016002427 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1166016002428 HTH domain; Region: HTH_11; pfam08279 1166016002429 Mga helix-turn-helix domain; Region: Mga; pfam05043 1166016002430 PRD domain; Region: PRD; pfam00874 1166016002431 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1166016002432 active site 1166016002433 P-loop; other site 1166016002434 phosphorylation site [posttranslational modification] 1166016002435 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1166016002436 active site 1166016002437 phosphorylation site [posttranslational modification] 1166016002438 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1166016002439 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1166016002440 dihydroorotase; Provisional; Region: PRK09237 1166016002441 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1166016002442 active site 1166016002443 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1166016002444 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1166016002445 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1166016002446 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1166016002447 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1166016002448 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1166016002449 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1166016002450 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1166016002451 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1166016002452 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166016002453 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166016002454 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1166016002455 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166016002456 homodimer interface [polypeptide binding]; other site 1166016002457 substrate-cofactor binding pocket; other site 1166016002458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016002459 catalytic residue [active] 1166016002460 L,D-transpeptidase; Provisional; Region: PRK10260 1166016002461 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166016002462 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1166016002463 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1166016002464 putative active site [active] 1166016002465 catalytic triad [active] 1166016002466 putative dimer interface [polypeptide binding]; other site 1166016002467 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1166016002468 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1166016002469 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1166016002470 dimer interface [polypeptide binding]; other site 1166016002471 PYR/PP interface [polypeptide binding]; other site 1166016002472 TPP binding site [chemical binding]; other site 1166016002473 substrate binding site [chemical binding]; other site 1166016002474 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1166016002475 Domain of unknown function; Region: EKR; smart00890 1166016002476 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1166016002477 4Fe-4S binding domain; Region: Fer4; pfam00037 1166016002478 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1166016002479 TPP-binding site [chemical binding]; other site 1166016002480 dimer interface [polypeptide binding]; other site 1166016002481 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1166016002482 active site 1166016002483 putative symporter YagG; Provisional; Region: PRK09669 1166016002484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002485 putative substrate translocation pore; other site 1166016002486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016002487 Coenzyme A binding pocket [chemical binding]; other site 1166016002488 LysE type translocator; Region: LysE; cl00565 1166016002489 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1166016002490 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 1166016002491 Fic/DOC family; Region: Fic; cl00960 1166016002492 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1166016002493 Predicted transcriptional regulator [Transcription]; Region: COG3905 1166016002494 Siderophore-interacting FAD-binding domain; Region: FAD_binding_9; pfam08021 1166016002495 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1166016002496 IucA / IucC family; Region: IucA_IucC; pfam04183 1166016002497 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1166016002498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1166016002499 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1166016002500 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1166016002501 IucA / IucC family; Region: IucA_IucC; pfam04183 1166016002502 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1166016002503 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1166016002504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016002505 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166016002506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016002507 N-terminal plug; other site 1166016002508 ligand-binding site [chemical binding]; other site 1166016002509 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1166016002510 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1166016002511 Predicted ATPase [General function prediction only]; Region: COG3911 1166016002512 AAA domain; Region: AAA_28; pfam13521 1166016002513 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1166016002514 integrase; Provisional; Region: PRK09692 1166016002515 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016002516 active site 1166016002517 Int/Topo IB signature motif; other site 1166016002518 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1166016002519 SmpB-tmRNA interface; other site 1166016002520 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1166016002521 putative coenzyme Q binding site [chemical binding]; other site 1166016002522 hypothetical protein; Validated; Region: PRK01777 1166016002523 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1166016002524 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1166016002525 recombination and repair protein; Provisional; Region: PRK10869 1166016002526 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1166016002527 Walker A/P-loop; other site 1166016002528 ATP binding site [chemical binding]; other site 1166016002529 Q-loop/lid; other site 1166016002530 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1166016002531 ABC transporter signature motif; other site 1166016002532 Walker B; other site 1166016002533 D-loop; other site 1166016002534 H-loop/switch region; other site 1166016002535 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1166016002536 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1166016002537 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1166016002538 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1166016002539 dimer interface [polypeptide binding]; other site 1166016002540 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1166016002541 manganese transport protein MntH; Reviewed; Region: PRK00701 1166016002542 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1166016002543 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1166016002544 active site 1 [active] 1166016002545 dimer interface [polypeptide binding]; other site 1166016002546 hexamer interface [polypeptide binding]; other site 1166016002547 active site 2 [active] 1166016002548 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1166016002549 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166016002550 dimer interface [polypeptide binding]; other site 1166016002551 ADP-ribose binding site [chemical binding]; other site 1166016002552 active site 1166016002553 nudix motif; other site 1166016002554 metal binding site [ion binding]; metal-binding site 1166016002555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166016002556 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016002557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002558 dimer interface [polypeptide binding]; other site 1166016002559 conserved gate region; other site 1166016002560 putative PBP binding loops; other site 1166016002561 ABC-ATPase subunit interface; other site 1166016002562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166016002563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002564 dimer interface [polypeptide binding]; other site 1166016002565 conserved gate region; other site 1166016002566 putative PBP binding loops; other site 1166016002567 ABC-ATPase subunit interface; other site 1166016002568 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1166016002569 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166016002570 Walker A/P-loop; other site 1166016002571 ATP binding site [chemical binding]; other site 1166016002572 Q-loop/lid; other site 1166016002573 ABC transporter signature motif; other site 1166016002574 Walker B; other site 1166016002575 D-loop; other site 1166016002576 H-loop/switch region; other site 1166016002577 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1166016002578 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1166016002579 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1166016002580 putative sugar binding sites [chemical binding]; other site 1166016002581 Q-X-W motif; other site 1166016002582 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1166016002583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016002584 DNA binding site [nucleotide binding] 1166016002585 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1166016002586 putative dimerization interface [polypeptide binding]; other site 1166016002587 putative ligand binding site [chemical binding]; other site 1166016002588 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1166016002589 CAT RNA binding domain; Region: CAT_RBD; smart01061 1166016002590 PRD domain; Region: PRD; pfam00874 1166016002591 PRD domain; Region: PRD; pfam00874 1166016002592 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1166016002593 beta-galactosidase; Region: BGL; TIGR03356 1166016002594 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1166016002595 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016002596 active site turn [active] 1166016002597 phosphorylation site [posttranslational modification] 1166016002598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016002599 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1166016002600 HPr interaction site; other site 1166016002601 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166016002602 active site 1166016002603 phosphorylation site [posttranslational modification] 1166016002604 transketolase; Reviewed; Region: PRK12753 1166016002605 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166016002606 TPP-binding site [chemical binding]; other site 1166016002607 dimer interface [polypeptide binding]; other site 1166016002608 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166016002609 PYR/PP interface [polypeptide binding]; other site 1166016002610 dimer interface [polypeptide binding]; other site 1166016002611 TPP binding site [chemical binding]; other site 1166016002612 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166016002613 transaldolase-like protein; Provisional; Region: PTZ00411 1166016002614 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1166016002615 active site 1166016002616 dimer interface [polypeptide binding]; other site 1166016002617 catalytic residue [active] 1166016002618 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1166016002619 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1166016002620 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1166016002621 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1166016002622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1166016002623 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1166016002624 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1166016002625 triosephosphate isomerase; Provisional; Region: PRK14567 1166016002626 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1166016002627 substrate binding site [chemical binding]; other site 1166016002628 dimer interface [polypeptide binding]; other site 1166016002629 catalytic triad [active] 1166016002630 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1166016002631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016002632 DNA binding residues [nucleotide binding] 1166016002633 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1166016002634 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1166016002635 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1166016002636 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1166016002637 putative NAD(P) binding site [chemical binding]; other site 1166016002638 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1166016002639 tryptophan permease; Provisional; Region: PRK10483 1166016002640 aromatic amino acid transport protein; Region: araaP; TIGR00837 1166016002641 hypothetical protein; Validated; Region: PRK00124 1166016002642 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1166016002643 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1166016002644 putative acetyltransferase; Provisional; Region: PRK03624 1166016002645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016002646 Coenzyme A binding pocket [chemical binding]; other site 1166016002647 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1166016002648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016002649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016002650 DNA binding residues [nucleotide binding] 1166016002651 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1166016002652 FecR protein; Region: FecR; pfam04773 1166016002653 Secretin and TonB N terminus short domain; Region: STN; smart00965 1166016002654 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016002655 hypothetical protein; Region: PHA02067 1166016002656 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1166016002657 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1166016002658 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166016002659 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1166016002660 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1166016002661 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1166016002662 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1166016002663 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1166016002664 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1166016002665 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1166016002666 thiosulfate transporter subunit; Provisional; Region: PRK10852 1166016002667 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166016002668 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166016002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002670 dimer interface [polypeptide binding]; other site 1166016002671 conserved gate region; other site 1166016002672 putative PBP binding loops; other site 1166016002673 ABC-ATPase subunit interface; other site 1166016002674 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166016002675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002676 dimer interface [polypeptide binding]; other site 1166016002677 conserved gate region; other site 1166016002678 putative PBP binding loops; other site 1166016002679 ABC-ATPase subunit interface; other site 1166016002680 cysteine synthase B; Region: cysM; TIGR01138 1166016002681 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1166016002682 dimer interface [polypeptide binding]; other site 1166016002683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016002684 catalytic residue [active] 1166016002685 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1166016002686 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166016002687 Walker A/P-loop; other site 1166016002688 ATP binding site [chemical binding]; other site 1166016002689 Q-loop/lid; other site 1166016002690 ABC transporter signature motif; other site 1166016002691 Walker B; other site 1166016002692 D-loop; other site 1166016002693 H-loop/switch region; other site 1166016002694 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166016002695 FtsX-like permease family; Region: FtsX; pfam02687 1166016002696 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1166016002697 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016002698 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016002699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1166016002700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016002701 active site 1166016002702 phosphorylation site [posttranslational modification] 1166016002703 intermolecular recognition site; other site 1166016002704 dimerization interface [polypeptide binding]; other site 1166016002705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016002706 DNA binding site [nucleotide binding] 1166016002707 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1166016002708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016002709 dimerization interface [polypeptide binding]; other site 1166016002710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016002711 dimer interface [polypeptide binding]; other site 1166016002712 phosphorylation site [posttranslational modification] 1166016002713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016002714 ATP binding site [chemical binding]; other site 1166016002715 Mg2+ binding site [ion binding]; other site 1166016002716 G-X-G motif; other site 1166016002717 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1166016002718 HPr interaction site; other site 1166016002719 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166016002720 active site 1166016002721 phosphorylation site [posttranslational modification] 1166016002722 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1166016002723 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1166016002724 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1166016002725 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1166016002726 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1166016002727 dimerization domain swap beta strand [polypeptide binding]; other site 1166016002728 regulatory protein interface [polypeptide binding]; other site 1166016002729 active site 1166016002730 regulatory phosphorylation site [posttranslational modification]; other site 1166016002731 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1166016002732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016002733 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1166016002734 cell division protein ZipA; Provisional; Region: PRK03427 1166016002735 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1166016002736 FtsZ protein binding site [polypeptide binding]; other site 1166016002737 putative transporter; Provisional; Region: PRK11021 1166016002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1166016002739 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1166016002740 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1166016002741 tellurite resistance protein TehB; Provisional; Region: PRK12335 1166016002742 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1166016002743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016002744 S-adenosylmethionine binding site [chemical binding]; other site 1166016002745 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1166016002746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016002747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016002748 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1166016002749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166016002750 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166016002751 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1166016002752 iron binding site [ion binding]; other site 1166016002753 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1166016002754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166016002755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016002756 Walker A motif; other site 1166016002757 ATP binding site [chemical binding]; other site 1166016002758 Walker B motif; other site 1166016002759 arginine finger; other site 1166016002760 fumarate hydratase; Provisional; Region: PRK15389 1166016002761 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1166016002762 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1166016002763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016002764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016002765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016002766 dimerization interface [polypeptide binding]; other site 1166016002767 Predicted membrane protein [Function unknown]; Region: COG4125 1166016002768 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1166016002769 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1166016002770 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1166016002771 endonuclease III; Region: ENDO3c; smart00478 1166016002772 minor groove reading motif; other site 1166016002773 helix-hairpin-helix signature motif; other site 1166016002774 substrate binding pocket [chemical binding]; other site 1166016002775 active site 1166016002776 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1166016002777 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1166016002778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016002779 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1166016002780 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166016002781 DNA binding site [nucleotide binding] 1166016002782 active site 1166016002783 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1166016002784 hypothetical protein; Validated; Region: PRK07121 1166016002785 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1166016002786 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1166016002787 FMN-binding domain; Region: FMN_bind; pfam04205 1166016002788 putative transporter; Provisional; Region: PRK10504 1166016002789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002790 putative substrate translocation pore; other site 1166016002791 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1166016002792 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1166016002793 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1166016002794 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016002795 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1166016002796 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1166016002797 substrate binding pocket [chemical binding]; other site 1166016002798 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016002799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016002800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016002801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016002802 dimerization interface [polypeptide binding]; other site 1166016002803 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1166016002804 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1166016002805 putative active site pocket [active] 1166016002806 putative metal binding site [ion binding]; other site 1166016002807 putative oxidoreductase; Provisional; Region: PRK10083 1166016002808 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1166016002809 putative NAD(P) binding site [chemical binding]; other site 1166016002810 catalytic Zn binding site [ion binding]; other site 1166016002811 structural Zn binding site [ion binding]; other site 1166016002812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002813 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166016002814 putative substrate translocation pore; other site 1166016002815 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1166016002816 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166016002817 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166016002818 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166016002819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016002820 DNA-binding site [nucleotide binding]; DNA binding site 1166016002821 FCD domain; Region: FCD; pfam07729 1166016002822 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1166016002823 drug efflux system protein MdtG; Provisional; Region: PRK09874 1166016002824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002825 putative substrate translocation pore; other site 1166016002826 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1166016002827 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1166016002828 Na binding site [ion binding]; other site 1166016002829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166016002830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016002831 DNA binding residues [nucleotide binding] 1166016002832 dimerization interface [polypeptide binding]; other site 1166016002833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016002834 Coenzyme A binding pocket [chemical binding]; other site 1166016002835 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016002836 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016002837 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016002838 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1166016002839 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1166016002840 active site residue [active] 1166016002841 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1166016002842 active site residue [active] 1166016002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002844 dimer interface [polypeptide binding]; other site 1166016002845 conserved gate region; other site 1166016002846 putative PBP binding loops; other site 1166016002847 ABC-ATPase subunit interface; other site 1166016002848 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016002849 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016002850 Walker A/P-loop; other site 1166016002851 ATP binding site [chemical binding]; other site 1166016002852 Q-loop/lid; other site 1166016002853 ABC transporter signature motif; other site 1166016002854 Walker B; other site 1166016002855 D-loop; other site 1166016002856 H-loop/switch region; other site 1166016002857 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016002858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002859 dimer interface [polypeptide binding]; other site 1166016002860 conserved gate region; other site 1166016002861 putative PBP binding loops; other site 1166016002862 ABC-ATPase subunit interface; other site 1166016002863 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016002864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016002865 substrate binding pocket [chemical binding]; other site 1166016002866 membrane-bound complex binding site; other site 1166016002867 hinge residues; other site 1166016002868 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1166016002869 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1166016002870 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166016002871 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1166016002872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1166016002873 homodimer interface [polypeptide binding]; other site 1166016002874 substrate-cofactor binding pocket; other site 1166016002875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016002876 catalytic residue [active] 1166016002877 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 1166016002878 active site 1166016002879 metal binding site [ion binding]; metal-binding site 1166016002880 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1166016002881 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1166016002882 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016002883 N-terminal plug; other site 1166016002884 ligand-binding site [chemical binding]; other site 1166016002885 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1166016002886 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1166016002887 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1166016002888 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166016002889 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166016002890 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1166016002891 DNA binding site [nucleotide binding] 1166016002892 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1166016002893 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166016002894 hypothetical protein; Provisional; Region: PRK10621 1166016002895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016002896 Coenzyme A binding pocket [chemical binding]; other site 1166016002897 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016002898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016002899 dimer interface [polypeptide binding]; other site 1166016002900 conserved gate region; other site 1166016002901 putative PBP binding loops; other site 1166016002902 ABC-ATPase subunit interface; other site 1166016002903 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1166016002904 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1166016002905 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1166016002906 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1166016002907 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1166016002908 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 1166016002909 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1166016002910 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1166016002911 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1166016002912 phosphopeptide binding site; other site 1166016002913 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 1166016002914 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1166016002915 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1166016002916 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1166016002917 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1166016002918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016002919 Walker A motif; other site 1166016002920 ATP binding site [chemical binding]; other site 1166016002921 Walker B motif; other site 1166016002922 arginine finger; other site 1166016002923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016002924 Walker A motif; other site 1166016002925 ATP binding site [chemical binding]; other site 1166016002926 Walker B motif; other site 1166016002927 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166016002928 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1166016002929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016002930 Walker A motif; other site 1166016002931 ATP binding site [chemical binding]; other site 1166016002932 Walker B motif; other site 1166016002933 arginine finger; other site 1166016002934 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 1166016002935 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1166016002936 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1166016002937 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1166016002938 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1166016002939 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1166016002940 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1166016002941 ImpA domain protein; Region: DUF3702; pfam12486 1166016002942 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1166016002943 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1166016002944 Transcription elongation factor Spt4; Region: Spt4; cl12033 1166016002945 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016002946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016002947 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1166016002948 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1166016002949 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 1166016002950 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1166016002951 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1166016002952 substrate binding pocket [chemical binding]; other site 1166016002953 active site 1166016002954 iron coordination sites [ion binding]; other site 1166016002955 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1166016002956 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1166016002957 active site 1166016002958 TDP-binding site; other site 1166016002959 acceptor substrate-binding pocket; other site 1166016002960 glutaredoxin 2; Provisional; Region: PRK10387 1166016002961 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1166016002962 C-terminal domain interface [polypeptide binding]; other site 1166016002963 GSH binding site (G-site) [chemical binding]; other site 1166016002964 catalytic residues [active] 1166016002965 putative dimer interface [polypeptide binding]; other site 1166016002966 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1166016002967 N-terminal domain interface [polypeptide binding]; other site 1166016002968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016002969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016002970 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166016002971 putative effector binding pocket; other site 1166016002972 dimerization interface [polypeptide binding]; other site 1166016002973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016002974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016002975 putative substrate translocation pore; other site 1166016002976 Cache domain; Region: Cache_1; pfam02743 1166016002977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016002978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016002979 metal binding site [ion binding]; metal-binding site 1166016002980 active site 1166016002981 I-site; other site 1166016002982 inner membrane protein; Provisional; Region: PRK10995 1166016002983 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1166016002984 putative hydrophobic ligand binding site [chemical binding]; other site 1166016002985 hypothetical protein; Validated; Region: PRK03661 1166016002986 recombinase A; Provisional; Region: recA; PRK09354 1166016002987 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1166016002988 hexamer interface [polypeptide binding]; other site 1166016002989 Walker A motif; other site 1166016002990 ATP binding site [chemical binding]; other site 1166016002991 Walker B motif; other site 1166016002992 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1166016002993 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1166016002994 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1166016002995 motif 1; other site 1166016002996 active site 1166016002997 motif 2; other site 1166016002998 motif 3; other site 1166016002999 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1166016003000 DHHA1 domain; Region: DHHA1; pfam02272 1166016003001 carbon storage regulator; Provisional; Region: PRK01712 1166016003002 HTH-like domain; Region: HTH_21; pfam13276 1166016003003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016003004 Integrase core domain; Region: rve; pfam00665 1166016003005 Integrase core domain; Region: rve_3; pfam13683 1166016003006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016003007 Transposase; Region: HTH_Tnp_1; pfam01527 1166016003008 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1166016003009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016003010 motif II; other site 1166016003011 Predicted membrane protein [Function unknown]; Region: COG1238 1166016003012 glutamate--cysteine ligase; Provisional; Region: PRK02107 1166016003013 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1166016003014 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1166016003015 signal recognition particle protein; Provisional; Region: PRK10867 1166016003016 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1166016003017 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1166016003018 P loop; other site 1166016003019 GTP binding site [chemical binding]; other site 1166016003020 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1166016003021 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1166016003022 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1166016003023 RimM N-terminal domain; Region: RimM; pfam01782 1166016003024 PRC-barrel domain; Region: PRC; pfam05239 1166016003025 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1166016003026 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1166016003027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016003028 lipoprotein; Provisional; Region: PRK11443 1166016003029 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1166016003030 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1166016003031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016003032 active site 1166016003033 phosphorylation site [posttranslational modification] 1166016003034 intermolecular recognition site; other site 1166016003035 dimerization interface [polypeptide binding]; other site 1166016003036 LytTr DNA-binding domain; Region: LytTR; pfam04397 1166016003037 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1166016003038 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166016003039 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1166016003040 Chorismate mutase type II; Region: CM_2; cl00693 1166016003041 prephenate dehydrogenase; Validated; Region: PRK08507 1166016003042 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1166016003043 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1166016003044 Prephenate dehydratase; Region: PDT; pfam00800 1166016003045 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1166016003046 putative L-Phe binding site [chemical binding]; other site 1166016003047 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1166016003048 30S subunit binding site; other site 1166016003049 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1166016003050 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1166016003051 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016003052 RNA binding surface [nucleotide binding]; other site 1166016003053 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1166016003054 active site 1166016003055 hypothetical protein; Provisional; Region: PRK10723 1166016003056 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1166016003057 protein disaggregation chaperone; Provisional; Region: PRK10865 1166016003058 Clp amino terminal domain; Region: Clp_N; pfam02861 1166016003059 Clp amino terminal domain; Region: Clp_N; pfam02861 1166016003060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016003061 Walker A motif; other site 1166016003062 ATP binding site [chemical binding]; other site 1166016003063 Walker B motif; other site 1166016003064 arginine finger; other site 1166016003065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016003066 Walker A motif; other site 1166016003067 ATP binding site [chemical binding]; other site 1166016003068 Walker B motif; other site 1166016003069 arginine finger; other site 1166016003070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1166016003071 hypothetical protein; Provisional; Region: PRK05421 1166016003072 putative catalytic site [active] 1166016003073 putative metal binding site [ion binding]; other site 1166016003074 putative phosphate binding site [ion binding]; other site 1166016003075 putative catalytic site [active] 1166016003076 putative phosphate binding site [ion binding]; other site 1166016003077 putative metal binding site [ion binding]; other site 1166016003078 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1166016003079 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016003080 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016003081 catalytic residue [active] 1166016003082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166016003083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166016003084 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1166016003085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016003086 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1166016003087 RNA/DNA hybrid binding site [nucleotide binding]; other site 1166016003088 active site 1166016003089 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1166016003090 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1166016003091 active site 1166016003092 catalytic site [active] 1166016003093 substrate binding site [chemical binding]; other site 1166016003094 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1166016003095 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1166016003096 dimer interface [polypeptide binding]; other site 1166016003097 putative radical transfer pathway; other site 1166016003098 diiron center [ion binding]; other site 1166016003099 tyrosyl radical; other site 1166016003100 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1166016003101 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1166016003102 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1166016003103 active site 1166016003104 dimer interface [polypeptide binding]; other site 1166016003105 catalytic residues [active] 1166016003106 effector binding site; other site 1166016003107 R2 peptide binding site; other site 1166016003108 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1166016003109 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1166016003110 catalytic residues [active] 1166016003111 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1166016003112 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166016003113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003114 dimer interface [polypeptide binding]; other site 1166016003115 conserved gate region; other site 1166016003116 putative PBP binding loops; other site 1166016003117 ABC-ATPase subunit interface; other site 1166016003118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003119 dimer interface [polypeptide binding]; other site 1166016003120 conserved gate region; other site 1166016003121 putative PBP binding loops; other site 1166016003122 ABC-ATPase subunit interface; other site 1166016003123 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166016003124 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1166016003125 Walker A/P-loop; other site 1166016003126 ATP binding site [chemical binding]; other site 1166016003127 Q-loop/lid; other site 1166016003128 ABC transporter signature motif; other site 1166016003129 Walker B; other site 1166016003130 D-loop; other site 1166016003131 H-loop/switch region; other site 1166016003132 TOBE domain; Region: TOBE_2; pfam08402 1166016003133 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166016003134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016003135 Coenzyme A binding pocket [chemical binding]; other site 1166016003136 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016003137 active site 1166016003138 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1166016003139 active site clefts [active] 1166016003140 zinc binding site [ion binding]; other site 1166016003141 dimer interface [polypeptide binding]; other site 1166016003142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1166016003143 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1166016003144 Walker A/P-loop; other site 1166016003145 ATP binding site [chemical binding]; other site 1166016003146 Q-loop/lid; other site 1166016003147 ABC transporter signature motif; other site 1166016003148 Walker B; other site 1166016003149 D-loop; other site 1166016003150 H-loop/switch region; other site 1166016003151 inner membrane transport permease; Provisional; Region: PRK15066 1166016003152 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166016003153 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1166016003154 tetramerization interface [polypeptide binding]; other site 1166016003155 active site 1166016003156 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1166016003157 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1166016003158 active site 1166016003159 ATP-binding site [chemical binding]; other site 1166016003160 pantoate-binding site; other site 1166016003161 HXXH motif; other site 1166016003162 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1166016003163 oligomerization interface [polypeptide binding]; other site 1166016003164 active site 1166016003165 metal binding site [ion binding]; metal-binding site 1166016003166 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1166016003167 catalytic center binding site [active] 1166016003168 ATP binding site [chemical binding]; other site 1166016003169 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1166016003170 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1166016003171 active site 1166016003172 NTP binding site [chemical binding]; other site 1166016003173 metal binding triad [ion binding]; metal-binding site 1166016003174 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1166016003175 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1166016003176 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1166016003177 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1166016003178 active site 1166016003179 nucleotide binding site [chemical binding]; other site 1166016003180 HIGH motif; other site 1166016003181 KMSKS motif; other site 1166016003182 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1166016003183 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1166016003184 2'-5' RNA ligase; Provisional; Region: PRK15124 1166016003185 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1166016003186 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1166016003187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016003188 ATP binding site [chemical binding]; other site 1166016003189 putative Mg++ binding site [ion binding]; other site 1166016003190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016003191 nucleotide binding region [chemical binding]; other site 1166016003192 ATP-binding site [chemical binding]; other site 1166016003193 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1166016003194 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1166016003195 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1166016003196 Transglycosylase; Region: Transgly; pfam00912 1166016003197 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1166016003198 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1166016003199 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016003200 Walker A/P-loop; other site 1166016003201 ATP binding site [chemical binding]; other site 1166016003202 Q-loop/lid; other site 1166016003203 ABC transporter signature motif; other site 1166016003204 Walker B; other site 1166016003205 D-loop; other site 1166016003206 H-loop/switch region; other site 1166016003207 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1166016003208 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1166016003209 siderophore binding site; other site 1166016003210 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016003211 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1166016003212 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016003213 ABC-ATPase subunit interface; other site 1166016003214 dimer interface [polypeptide binding]; other site 1166016003215 putative PBP binding regions; other site 1166016003216 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016003217 ABC-ATPase subunit interface; other site 1166016003218 dimer interface [polypeptide binding]; other site 1166016003219 putative PBP binding regions; other site 1166016003220 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166016003221 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166016003222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016003223 DNA-binding site [nucleotide binding]; DNA binding site 1166016003224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016003225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016003226 homodimer interface [polypeptide binding]; other site 1166016003227 catalytic residue [active] 1166016003228 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166016003229 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1166016003230 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1166016003231 putative N-terminal domain interface [polypeptide binding]; other site 1166016003232 putative dimer interface [polypeptide binding]; other site 1166016003233 putative substrate binding pocket (H-site) [chemical binding]; other site 1166016003234 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1166016003235 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016003236 inhibitor-cofactor binding pocket; inhibition site 1166016003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016003238 catalytic residue [active] 1166016003239 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1166016003240 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1166016003241 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1166016003242 cobalamin binding residues [chemical binding]; other site 1166016003243 putative BtuC binding residues; other site 1166016003244 dimer interface [polypeptide binding]; other site 1166016003245 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1166016003246 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1166016003247 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1166016003248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1166016003249 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1166016003250 serine endoprotease; Provisional; Region: PRK10942 1166016003251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1166016003252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166016003253 protein binding site [polypeptide binding]; other site 1166016003254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1166016003255 protein binding site [polypeptide binding]; other site 1166016003256 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1166016003257 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1166016003258 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1166016003259 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166016003260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016003261 substrate binding pocket [chemical binding]; other site 1166016003262 membrane-bound complex binding site; other site 1166016003263 hinge residues; other site 1166016003264 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166016003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003266 dimer interface [polypeptide binding]; other site 1166016003267 conserved gate region; other site 1166016003268 putative PBP binding loops; other site 1166016003269 ABC-ATPase subunit interface; other site 1166016003270 sulfate transport protein; Provisional; Region: cysT; CHL00187 1166016003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003272 dimer interface [polypeptide binding]; other site 1166016003273 conserved gate region; other site 1166016003274 putative PBP binding loops; other site 1166016003275 ABC-ATPase subunit interface; other site 1166016003276 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1166016003277 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1166016003278 Walker A/P-loop; other site 1166016003279 ATP binding site [chemical binding]; other site 1166016003280 Q-loop/lid; other site 1166016003281 ABC transporter signature motif; other site 1166016003282 Walker B; other site 1166016003283 D-loop; other site 1166016003284 H-loop/switch region; other site 1166016003285 TOBE-like domain; Region: TOBE_3; pfam12857 1166016003286 DoxX; Region: DoxX; pfam07681 1166016003287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016003288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016003289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016003290 active site 1166016003291 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016003292 catalytic tetrad [active] 1166016003293 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166016003294 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1166016003295 putative active site [active] 1166016003296 putative FMN binding site [chemical binding]; other site 1166016003297 putative substrate binding site [chemical binding]; other site 1166016003298 putative catalytic residue [active] 1166016003299 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1166016003300 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1166016003301 active site 1166016003302 HIGH motif; other site 1166016003303 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1166016003304 active site 1166016003305 KMSKS motif; other site 1166016003306 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1166016003307 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1166016003308 ligand binding site [chemical binding]; other site 1166016003309 active site 1166016003310 UGI interface [polypeptide binding]; other site 1166016003311 catalytic site [active] 1166016003312 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1166016003313 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1166016003314 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166016003315 ATP binding site [chemical binding]; other site 1166016003316 Mg++ binding site [ion binding]; other site 1166016003317 motif III; other site 1166016003318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016003319 nucleotide binding region [chemical binding]; other site 1166016003320 ATP-binding site [chemical binding]; other site 1166016003321 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1166016003322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016003323 S-adenosylmethionine binding site [chemical binding]; other site 1166016003324 L-aspartate oxidase; Provisional; Region: PRK09077 1166016003325 L-aspartate oxidase; Provisional; Region: PRK06175 1166016003326 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1166016003327 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1166016003328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016003329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016003330 DNA binding residues [nucleotide binding] 1166016003331 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1166016003332 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1166016003333 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1166016003334 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1166016003335 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1166016003336 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1166016003337 GTP-binding protein LepA; Provisional; Region: PRK05433 1166016003338 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1166016003339 G1 box; other site 1166016003340 putative GEF interaction site [polypeptide binding]; other site 1166016003341 GTP/Mg2+ binding site [chemical binding]; other site 1166016003342 Switch I region; other site 1166016003343 G2 box; other site 1166016003344 G3 box; other site 1166016003345 Switch II region; other site 1166016003346 G4 box; other site 1166016003347 G5 box; other site 1166016003348 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1166016003349 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1166016003350 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1166016003351 signal peptidase I; Provisional; Region: PRK10861 1166016003352 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1166016003353 Catalytic site [active] 1166016003354 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1166016003355 ribonuclease III; Reviewed; Region: rnc; PRK00102 1166016003356 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1166016003357 dimerization interface [polypeptide binding]; other site 1166016003358 active site 1166016003359 metal binding site [ion binding]; metal-binding site 1166016003360 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1166016003361 dsRNA binding site [nucleotide binding]; other site 1166016003362 GTPase Era; Reviewed; Region: era; PRK00089 1166016003363 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1166016003364 G1 box; other site 1166016003365 GTP/Mg2+ binding site [chemical binding]; other site 1166016003366 Switch I region; other site 1166016003367 G2 box; other site 1166016003368 Switch II region; other site 1166016003369 G3 box; other site 1166016003370 G4 box; other site 1166016003371 G5 box; other site 1166016003372 KH domain; Region: KH_2; pfam07650 1166016003373 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1166016003374 Recombination protein O N terminal; Region: RecO_N; pfam11967 1166016003375 Recombination protein O C terminal; Region: RecO_C; pfam02565 1166016003376 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1166016003377 active site 1166016003378 hydrophilic channel; other site 1166016003379 dimerization interface [polypeptide binding]; other site 1166016003380 catalytic residues [active] 1166016003381 active site lid [active] 1166016003382 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1166016003383 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1166016003384 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016003385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016003386 PAS domain; Region: PAS_9; pfam13426 1166016003387 putative active site [active] 1166016003388 heme pocket [chemical binding]; other site 1166016003389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166016003390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1166016003391 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016003392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016003393 metal binding site [ion binding]; metal-binding site 1166016003394 active site 1166016003395 I-site; other site 1166016003396 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1166016003397 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016003398 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1166016003399 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016003400 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1166016003401 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1166016003402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016003403 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1166016003404 Walker A/P-loop; other site 1166016003405 ATP binding site [chemical binding]; other site 1166016003406 Q-loop/lid; other site 1166016003407 ABC transporter signature motif; other site 1166016003408 Walker B; other site 1166016003409 D-loop; other site 1166016003410 H-loop/switch region; other site 1166016003411 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1166016003412 VCBS repeat; Region: VCBS_repeat; TIGR01965 1166016003413 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1166016003414 HAMP domain; Region: HAMP; pfam00672 1166016003415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016003416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016003417 metal binding site [ion binding]; metal-binding site 1166016003418 active site 1166016003419 I-site; other site 1166016003420 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016003421 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1166016003422 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1166016003423 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1166016003424 putative active site [active] 1166016003425 hypothetical protein; Provisional; Region: PRK11590 1166016003426 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1166016003427 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1166016003428 nucleoside/Zn binding site; other site 1166016003429 dimer interface [polypeptide binding]; other site 1166016003430 catalytic motif [active] 1166016003431 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1166016003432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016003433 substrate binding pocket [chemical binding]; other site 1166016003434 membrane-bound complex binding site; other site 1166016003435 hinge residues; other site 1166016003436 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016003437 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016003438 catalytic residue [active] 1166016003439 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1166016003440 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1166016003441 dimerization interface [polypeptide binding]; other site 1166016003442 ATP binding site [chemical binding]; other site 1166016003443 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1166016003444 dimerization interface [polypeptide binding]; other site 1166016003445 ATP binding site [chemical binding]; other site 1166016003446 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1166016003447 putative active site [active] 1166016003448 catalytic triad [active] 1166016003449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1166016003450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016003451 dimer interface [polypeptide binding]; other site 1166016003452 phosphorylation site [posttranslational modification] 1166016003453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016003454 ATP binding site [chemical binding]; other site 1166016003455 Mg2+ binding site [ion binding]; other site 1166016003456 G-X-G motif; other site 1166016003457 hypothetical protein; Provisional; Region: PRK10722 1166016003458 response regulator GlrR; Provisional; Region: PRK15115 1166016003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016003460 active site 1166016003461 phosphorylation site [posttranslational modification] 1166016003462 intermolecular recognition site; other site 1166016003463 dimerization interface [polypeptide binding]; other site 1166016003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016003465 Walker A motif; other site 1166016003466 ATP binding site [chemical binding]; other site 1166016003467 Walker B motif; other site 1166016003468 arginine finger; other site 1166016003469 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1166016003470 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1166016003471 putative pectinesterase; Region: PLN02432; cl01911 1166016003472 Pectinesterase; Region: Pectinesterase; pfam01095 1166016003473 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1166016003474 active site 1166016003475 catalytic triad [active] 1166016003476 oxyanion hole [active] 1166016003477 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1166016003478 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1166016003479 heme-binding site [chemical binding]; other site 1166016003480 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1166016003481 FAD binding pocket [chemical binding]; other site 1166016003482 FAD binding motif [chemical binding]; other site 1166016003483 phosphate binding motif [ion binding]; other site 1166016003484 beta-alpha-beta structure motif; other site 1166016003485 NAD binding pocket [chemical binding]; other site 1166016003486 Heme binding pocket [chemical binding]; other site 1166016003487 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1166016003488 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1166016003489 dimer interface [polypeptide binding]; other site 1166016003490 active site 1166016003491 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1166016003492 folate binding site [chemical binding]; other site 1166016003493 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1166016003494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016003495 putative substrate translocation pore; other site 1166016003496 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1166016003497 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1166016003498 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1166016003499 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1166016003500 putative ligand binding residues [chemical binding]; other site 1166016003501 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016003502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1166016003503 dimerization interface [polypeptide binding]; other site 1166016003504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016003505 dimer interface [polypeptide binding]; other site 1166016003506 putative CheW interface [polypeptide binding]; other site 1166016003507 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016003508 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016003509 Walker A/P-loop; other site 1166016003510 ATP binding site [chemical binding]; other site 1166016003511 Q-loop/lid; other site 1166016003512 ABC transporter signature motif; other site 1166016003513 Walker B; other site 1166016003514 D-loop; other site 1166016003515 H-loop/switch region; other site 1166016003516 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016003517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016003518 ABC-ATPase subunit interface; other site 1166016003519 dimer interface [polypeptide binding]; other site 1166016003520 putative PBP binding regions; other site 1166016003521 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1166016003522 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166016003523 intersubunit interface [polypeptide binding]; other site 1166016003524 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1166016003525 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1166016003526 active site 1166016003527 dimerization interface [polypeptide binding]; other site 1166016003528 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1166016003529 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166016003530 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1166016003531 Rrf2 family protein; Region: rrf2_super; TIGR00738 1166016003532 cysteine desulfurase; Provisional; Region: PRK14012 1166016003533 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1166016003534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016003535 catalytic residue [active] 1166016003536 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1166016003537 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1166016003538 trimerization site [polypeptide binding]; other site 1166016003539 active site 1166016003540 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1166016003541 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1166016003542 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166016003543 HSP70 interaction site [polypeptide binding]; other site 1166016003544 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1166016003545 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1166016003546 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1166016003547 nucleotide binding site [chemical binding]; other site 1166016003548 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1166016003549 SBD interface [polypeptide binding]; other site 1166016003550 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1166016003551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166016003552 catalytic loop [active] 1166016003553 iron binding site [ion binding]; other site 1166016003554 hypothetical protein; Provisional; Region: PRK10721 1166016003555 aminopeptidase B; Provisional; Region: PRK05015 1166016003556 Peptidase; Region: DUF3663; pfam12404 1166016003557 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1166016003558 interface (dimer of trimers) [polypeptide binding]; other site 1166016003559 Substrate-binding/catalytic site; other site 1166016003560 Zn-binding sites [ion binding]; other site 1166016003561 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1166016003562 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1166016003563 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1166016003564 active site residue [active] 1166016003565 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1166016003566 active site residue [active] 1166016003567 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1166016003568 active site 1166016003569 multimer interface [polypeptide binding]; other site 1166016003570 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1166016003571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016003572 FeS/SAM binding site; other site 1166016003573 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1166016003574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016003575 binding surface 1166016003576 TPR motif; other site 1166016003577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016003578 binding surface 1166016003579 TPR motif; other site 1166016003580 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1166016003581 Helix-turn-helix domain; Region: HTH_25; pfam13413 1166016003582 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1166016003583 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1166016003584 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1166016003585 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1166016003586 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1166016003587 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1166016003588 dimer interface [polypeptide binding]; other site 1166016003589 motif 1; other site 1166016003590 active site 1166016003591 motif 2; other site 1166016003592 motif 3; other site 1166016003593 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1166016003594 anticodon binding site; other site 1166016003595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1166016003596 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1166016003597 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1166016003598 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1166016003599 Trp docking motif [polypeptide binding]; other site 1166016003600 GTP-binding protein Der; Reviewed; Region: PRK00093 1166016003601 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1166016003602 G1 box; other site 1166016003603 GTP/Mg2+ binding site [chemical binding]; other site 1166016003604 Switch I region; other site 1166016003605 G2 box; other site 1166016003606 Switch II region; other site 1166016003607 G3 box; other site 1166016003608 G4 box; other site 1166016003609 G5 box; other site 1166016003610 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1166016003611 G1 box; other site 1166016003612 GTP/Mg2+ binding site [chemical binding]; other site 1166016003613 Switch I region; other site 1166016003614 G2 box; other site 1166016003615 G3 box; other site 1166016003616 Switch II region; other site 1166016003617 G4 box; other site 1166016003618 G5 box; other site 1166016003619 Predicted permeases [General function prediction only]; Region: COG0679 1166016003620 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1166016003621 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1166016003622 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1166016003623 active site 1166016003624 Zn binding site [ion binding]; other site 1166016003625 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1166016003626 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1166016003627 generic binding surface II; other site 1166016003628 generic binding surface I; other site 1166016003629 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1166016003630 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1166016003631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1166016003632 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1166016003633 active site 1166016003634 GMP synthase; Reviewed; Region: guaA; PRK00074 1166016003635 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1166016003636 AMP/PPi binding site [chemical binding]; other site 1166016003637 candidate oxyanion hole; other site 1166016003638 catalytic triad [active] 1166016003639 potential glutamine specificity residues [chemical binding]; other site 1166016003640 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1166016003641 ATP Binding subdomain [chemical binding]; other site 1166016003642 Ligand Binding sites [chemical binding]; other site 1166016003643 Dimerization subdomain; other site 1166016003644 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1166016003645 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1166016003646 ATP binding site [chemical binding]; other site 1166016003647 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016003648 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016003649 active site 1166016003650 catalytic tetrad [active] 1166016003651 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1166016003652 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166016003653 putative NAD(P) binding site [chemical binding]; other site 1166016003654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016003655 Sel1-like repeats; Region: SEL1; smart00671 1166016003656 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1166016003657 Sel1-like repeats; Region: SEL1; smart00671 1166016003658 Sel1-like repeats; Region: SEL1; smart00671 1166016003659 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1166016003660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016003661 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166016003662 YCII-related domain; Region: YCII; cl00999 1166016003663 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 1166016003664 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1166016003665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016003666 Coenzyme A binding pocket [chemical binding]; other site 1166016003667 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1166016003668 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1166016003669 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166016003670 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1166016003671 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1166016003672 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1166016003673 NAD binding site [chemical binding]; other site 1166016003674 substrate binding site [chemical binding]; other site 1166016003675 catalytic Zn binding site [ion binding]; other site 1166016003676 tetramer interface [polypeptide binding]; other site 1166016003677 structural Zn binding site [ion binding]; other site 1166016003678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016003679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016003680 metal binding site [ion binding]; metal-binding site 1166016003681 active site 1166016003682 I-site; other site 1166016003683 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1166016003684 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1166016003685 putative NAD(P) binding site [chemical binding]; other site 1166016003686 putative substrate binding site [chemical binding]; other site 1166016003687 catalytic Zn binding site [ion binding]; other site 1166016003688 structural Zn binding site [ion binding]; other site 1166016003689 dimer interface [polypeptide binding]; other site 1166016003690 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1166016003691 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1166016003692 substrate binding site [chemical binding]; other site 1166016003693 ligand binding site [chemical binding]; other site 1166016003694 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1166016003695 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1166016003696 substrate binding site [chemical binding]; other site 1166016003697 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1166016003698 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1166016003699 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1166016003700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016003701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016003702 dimerization interface [polypeptide binding]; other site 1166016003703 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1166016003704 substrate binding site [chemical binding]; other site 1166016003705 multimerization interface [polypeptide binding]; other site 1166016003706 ATP binding site [chemical binding]; other site 1166016003707 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1166016003708 dimer interface [polypeptide binding]; other site 1166016003709 substrate binding site [chemical binding]; other site 1166016003710 ATP binding site [chemical binding]; other site 1166016003711 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1166016003712 lipid kinase; Reviewed; Region: PRK13054 1166016003713 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1166016003714 putative protease; Provisional; Region: PRK15452 1166016003715 Peptidase family U32; Region: Peptidase_U32; pfam01136 1166016003716 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1166016003717 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1166016003718 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1166016003719 putative dimer interface [polypeptide binding]; other site 1166016003720 N-terminal domain interface [polypeptide binding]; other site 1166016003721 putative substrate binding pocket (H-site) [chemical binding]; other site 1166016003722 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166016003723 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166016003724 Coenzyme A binding pocket [chemical binding]; other site 1166016003725 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1166016003726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016003727 active site 1166016003728 phosphorylation site [posttranslational modification] 1166016003729 intermolecular recognition site; other site 1166016003730 dimerization interface [polypeptide binding]; other site 1166016003731 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016003732 DNA binding site [nucleotide binding] 1166016003733 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1166016003734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016003735 dimerization interface [polypeptide binding]; other site 1166016003736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016003737 dimer interface [polypeptide binding]; other site 1166016003738 phosphorylation site [posttranslational modification] 1166016003739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016003740 ATP binding site [chemical binding]; other site 1166016003741 Mg2+ binding site [ion binding]; other site 1166016003742 G-X-G motif; other site 1166016003743 putative transporter; Provisional; Region: PRK10504 1166016003744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016003745 putative substrate translocation pore; other site 1166016003746 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1166016003747 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1166016003748 Protein export membrane protein; Region: SecD_SecF; cl14618 1166016003749 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1166016003750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016003751 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016003752 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1166016003753 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1166016003754 Nucleoside recognition; Region: Gate; pfam07670 1166016003755 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1166016003756 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016003757 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016003758 active site 1166016003759 catalytic tetrad [active] 1166016003760 D-lactate dehydrogenase; Provisional; Region: PRK11183 1166016003761 FAD binding domain; Region: FAD_binding_4; pfam01565 1166016003762 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1166016003763 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016003764 active site turn [active] 1166016003765 phosphorylation site [posttranslational modification] 1166016003766 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1166016003767 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1166016003768 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1166016003769 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1166016003770 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1166016003771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166016003772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003773 dimer interface [polypeptide binding]; other site 1166016003774 conserved gate region; other site 1166016003775 putative PBP binding loops; other site 1166016003776 ABC-ATPase subunit interface; other site 1166016003777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003778 dimer interface [polypeptide binding]; other site 1166016003779 conserved gate region; other site 1166016003780 ABC-ATPase subunit interface; other site 1166016003781 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1166016003782 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166016003783 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1166016003784 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166016003785 Walker A/P-loop; other site 1166016003786 ATP binding site [chemical binding]; other site 1166016003787 Q-loop/lid; other site 1166016003788 ABC transporter signature motif; other site 1166016003789 Walker B; other site 1166016003790 D-loop; other site 1166016003791 H-loop/switch region; other site 1166016003792 TOBE domain; Region: TOBE_2; pfam08402 1166016003793 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1166016003794 trimer interface; other site 1166016003795 sugar binding site [chemical binding]; other site 1166016003796 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1166016003797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016003798 DNA binding site [nucleotide binding] 1166016003799 domain linker motif; other site 1166016003800 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166016003801 dimerization interface (closed form) [polypeptide binding]; other site 1166016003802 ligand binding site [chemical binding]; other site 1166016003803 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1166016003804 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1166016003805 dimer interface [polypeptide binding]; other site 1166016003806 active site 1166016003807 galactokinase; Provisional; Region: PRK05101 1166016003808 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1166016003809 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1166016003810 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1166016003811 MgtE intracellular N domain; Region: MgtE_N; smart00924 1166016003812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1166016003813 Divalent cation transporter; Region: MgtE; cl00786 1166016003814 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1166016003815 MarR family; Region: MarR; pfam01047 1166016003816 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1166016003817 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1166016003818 Putative motility protein; Region: YjfB_motility; pfam14070 1166016003819 exopolyphosphatase; Provisional; Region: PRK10854 1166016003820 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166016003821 nucleotide binding site [chemical binding]; other site 1166016003822 polyphosphate kinase; Provisional; Region: PRK05443 1166016003823 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1166016003824 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1166016003825 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1166016003826 domain interface [polypeptide binding]; other site 1166016003827 active site 1166016003828 catalytic site [active] 1166016003829 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1166016003830 domain interface [polypeptide binding]; other site 1166016003831 active site 1166016003832 catalytic site [active] 1166016003833 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1166016003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003835 dimer interface [polypeptide binding]; other site 1166016003836 conserved gate region; other site 1166016003837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003838 dimer interface [polypeptide binding]; other site 1166016003839 conserved gate region; other site 1166016003840 putative PBP binding loops; other site 1166016003841 ABC-ATPase subunit interface; other site 1166016003842 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1166016003843 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1166016003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003845 dimer interface [polypeptide binding]; other site 1166016003846 conserved gate region; other site 1166016003847 ABC-ATPase subunit interface; other site 1166016003848 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1166016003849 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1166016003850 Walker A/P-loop; other site 1166016003851 ATP binding site [chemical binding]; other site 1166016003852 Q-loop/lid; other site 1166016003853 ABC transporter signature motif; other site 1166016003854 Walker B; other site 1166016003855 D-loop; other site 1166016003856 H-loop/switch region; other site 1166016003857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1166016003858 non-specific DNA binding site [nucleotide binding]; other site 1166016003859 salt bridge; other site 1166016003860 sequence-specific DNA binding site [nucleotide binding]; other site 1166016003861 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1166016003862 serine transporter; Region: stp; TIGR00814 1166016003863 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1166016003864 ATP-grasp domain; Region: ATP-grasp; pfam02222 1166016003865 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1166016003866 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1166016003867 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166016003868 putative active site [active] 1166016003869 putative metal binding site [ion binding]; other site 1166016003870 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1166016003871 substrate binding site [chemical binding]; other site 1166016003872 DoxX; Region: DoxX; pfam07681 1166016003873 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1166016003874 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1166016003875 active site 1166016003876 HIGH motif; other site 1166016003877 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1166016003878 KMSKS motif; other site 1166016003879 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1166016003880 tRNA binding surface [nucleotide binding]; other site 1166016003881 anticodon binding site; other site 1166016003882 ribosome-associated protein; Provisional; Region: PRK11507 1166016003883 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1166016003884 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1166016003885 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1166016003886 homodimer interface [polypeptide binding]; other site 1166016003887 NADP binding site [chemical binding]; other site 1166016003888 substrate binding site [chemical binding]; other site 1166016003889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016003890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016003891 metal binding site [ion binding]; metal-binding site 1166016003892 active site 1166016003893 I-site; other site 1166016003894 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1166016003895 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1166016003896 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1166016003897 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166016003898 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166016003899 inhibitor-cofactor binding pocket; inhibition site 1166016003900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016003901 catalytic residue [active] 1166016003902 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1166016003903 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1166016003904 Ligand binding site; other site 1166016003905 Putative Catalytic site; other site 1166016003906 DXD motif; other site 1166016003907 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1166016003908 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1166016003909 active site 1166016003910 substrate binding site [chemical binding]; other site 1166016003911 cosubstrate binding site; other site 1166016003912 catalytic site [active] 1166016003913 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1166016003914 active site 1166016003915 hexamer interface [polypeptide binding]; other site 1166016003916 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1166016003917 NAD binding site [chemical binding]; other site 1166016003918 substrate binding site [chemical binding]; other site 1166016003919 active site 1166016003920 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1166016003921 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1166016003922 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1166016003923 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1166016003924 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1166016003925 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1166016003926 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166016003927 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1166016003928 Walker A/P-loop; other site 1166016003929 ATP binding site [chemical binding]; other site 1166016003930 Q-loop/lid; other site 1166016003931 ABC transporter signature motif; other site 1166016003932 Walker B; other site 1166016003933 D-loop; other site 1166016003934 H-loop/switch region; other site 1166016003935 TOBE domain; Region: TOBE_2; pfam08402 1166016003936 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166016003937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003938 dimer interface [polypeptide binding]; other site 1166016003939 conserved gate region; other site 1166016003940 ABC-ATPase subunit interface; other site 1166016003941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016003942 dimer interface [polypeptide binding]; other site 1166016003943 conserved gate region; other site 1166016003944 putative PBP binding loops; other site 1166016003945 ABC-ATPase subunit interface; other site 1166016003946 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166016003947 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166016003948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016003949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016003950 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166016003951 putative effector binding pocket; other site 1166016003952 putative dimerization interface [polypeptide binding]; other site 1166016003953 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1166016003954 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1166016003955 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1166016003956 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1166016003957 acyl-activating enzyme (AAE) consensus motif; other site 1166016003958 AMP binding site [chemical binding]; other site 1166016003959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1166016003960 diaminopimelate aminotransferase; Provisional; Region: PRK13983 1166016003961 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1166016003962 metal binding site [ion binding]; metal-binding site 1166016003963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016003964 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166016003965 DNA binding residues [nucleotide binding] 1166016003966 dimerization interface [polypeptide binding]; other site 1166016003967 outer membrane protease; Reviewed; Region: PRK10993 1166016003968 methionine synthase; Provisional; Region: PRK01207 1166016003969 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1166016003970 substrate binding site [chemical binding]; other site 1166016003971 THF binding site; other site 1166016003972 zinc-binding site [ion binding]; other site 1166016003973 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1166016003974 HTH-like domain; Region: HTH_21; pfam13276 1166016003975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016003976 Integrase core domain; Region: rve; pfam00665 1166016003977 Integrase core domain; Region: rve_3; pfam13683 1166016003978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016003979 Transposase; Region: HTH_Tnp_1; pfam01527 1166016003980 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1166016003981 nudix motif; other site 1166016003982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016003983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016003984 Integrase core domain; Region: rve_3; pfam13683 1166016003985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016003986 Transposase; Region: HTH_Tnp_1; pfam01527 1166016003987 integrase; Provisional; Region: PRK09692 1166016003988 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016003989 active site 1166016003990 Int/Topo IB signature motif; other site 1166016003991 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1166016003992 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1166016003993 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166016003994 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1166016003995 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1166016003996 homodimer interface [polypeptide binding]; other site 1166016003997 substrate-cofactor binding pocket; other site 1166016003998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016003999 catalytic residue [active] 1166016004000 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1166016004001 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1166016004002 active site 1166016004003 aminotransferase; Validated; Region: PRK08175 1166016004004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016004005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016004006 homodimer interface [polypeptide binding]; other site 1166016004007 catalytic residue [active] 1166016004008 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1166016004009 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1166016004010 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1166016004011 Interdomain contacts; other site 1166016004012 Cytokine receptor motif; other site 1166016004013 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1166016004014 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1166016004015 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1166016004016 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1166016004017 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1166016004018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166016004019 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166016004020 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166016004021 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016004022 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1166016004023 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1166016004024 Walker A motif; other site 1166016004025 ATP binding site [chemical binding]; other site 1166016004026 Walker B motif; other site 1166016004027 type II secretion system protein F; Region: GspF; TIGR02120 1166016004028 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016004029 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016004030 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1166016004031 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1166016004032 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1166016004033 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1166016004034 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1166016004035 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1166016004036 type II secretion system protein I; Region: gspI; TIGR01707 1166016004037 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1166016004038 type II secretion system protein J; Region: gspJ; TIGR01711 1166016004039 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1166016004040 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1166016004041 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1166016004042 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1166016004043 GspL periplasmic domain; Region: GspL_C; pfam12693 1166016004044 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1166016004045 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1166016004046 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1166016004047 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1166016004048 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1166016004049 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1166016004050 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1166016004051 putative ligand binding residues [chemical binding]; other site 1166016004052 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1166016004053 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016004054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016004055 ABC-ATPase subunit interface; other site 1166016004056 dimer interface [polypeptide binding]; other site 1166016004057 putative PBP binding regions; other site 1166016004058 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016004059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016004060 Walker A/P-loop; other site 1166016004061 ATP binding site [chemical binding]; other site 1166016004062 Q-loop/lid; other site 1166016004063 ABC transporter signature motif; other site 1166016004064 Walker B; other site 1166016004065 D-loop; other site 1166016004066 H-loop/switch region; other site 1166016004067 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166016004068 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1166016004069 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1166016004070 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016004071 ATP binding site [chemical binding]; other site 1166016004072 putative Mg++ binding site [ion binding]; other site 1166016004073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016004074 nucleotide binding region [chemical binding]; other site 1166016004075 ATP-binding site [chemical binding]; other site 1166016004076 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1166016004077 putative RNA binding site [nucleotide binding]; other site 1166016004078 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1166016004079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166016004080 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1166016004081 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166016004082 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1166016004083 malate:quinone oxidoreductase; Validated; Region: PRK05257 1166016004084 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1166016004085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016004086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016004087 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166016004088 putative effector binding pocket; other site 1166016004089 dimerization interface [polypeptide binding]; other site 1166016004090 short chain dehydrogenase; Provisional; Region: PRK06500 1166016004091 classical (c) SDRs; Region: SDR_c; cd05233 1166016004092 NAD(P) binding site [chemical binding]; other site 1166016004093 active site 1166016004094 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1166016004095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1166016004096 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1166016004097 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166016004098 dimer interface [polypeptide binding]; other site 1166016004099 active site 1166016004100 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1166016004101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166016004102 substrate binding site [chemical binding]; other site 1166016004103 oxyanion hole (OAH) forming residues; other site 1166016004104 trimer interface [polypeptide binding]; other site 1166016004105 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1166016004106 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166016004107 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166016004108 Spore Coat Protein U domain; Region: SCPU; smart00972 1166016004109 Spore Coat Protein U domain; Region: SCPU; pfam05229 1166016004110 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166016004111 PapC N-terminal domain; Region: PapC_N; pfam13954 1166016004112 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166016004113 PapC C-terminal domain; Region: PapC_C; pfam13953 1166016004114 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1166016004115 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166016004116 Spore Coat Protein U domain; Region: SCPU; pfam05229 1166016004117 Spore Coat Protein U domain; Region: SCPU; pfam05229 1166016004118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166016004119 catalytic core [active] 1166016004120 hypothetical protein; Provisional; Region: PRK04946 1166016004121 Smr domain; Region: Smr; pfam01713 1166016004122 HemK family putative methylases; Region: hemK_fam; TIGR00536 1166016004123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016004124 S-adenosylmethionine binding site [chemical binding]; other site 1166016004125 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1166016004126 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1166016004127 Tetramer interface [polypeptide binding]; other site 1166016004128 active site 1166016004129 FMN-binding site [chemical binding]; other site 1166016004130 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1166016004131 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1166016004132 hypothetical protein; Provisional; Region: PRK10621 1166016004133 Predicted permeases [General function prediction only]; Region: COG0730 1166016004134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1166016004135 YfcL protein; Region: YfcL; pfam08891 1166016004136 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1166016004137 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1166016004138 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1166016004139 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166016004140 dimer interface [polypeptide binding]; other site 1166016004141 active site 1166016004142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1166016004143 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1166016004144 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016004145 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1166016004146 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1166016004147 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166016004148 EamA-like transporter family; Region: EamA; pfam00892 1166016004149 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1166016004150 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1166016004151 ligand binding site [chemical binding]; other site 1166016004152 NAD binding site [chemical binding]; other site 1166016004153 catalytic site [active] 1166016004154 homodimer interface [polypeptide binding]; other site 1166016004155 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1166016004156 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1166016004157 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1166016004158 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1166016004159 dimerization interface 3.5A [polypeptide binding]; other site 1166016004160 active site 1166016004161 hypothetical protein; Provisional; Region: PRK10847 1166016004162 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166016004163 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1166016004164 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1166016004165 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1166016004166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166016004167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166016004168 cell division protein DedD; Provisional; Region: PRK11633 1166016004169 Sporulation related domain; Region: SPOR; pfam05036 1166016004170 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1166016004171 colicin V production protein; Provisional; Region: PRK10845 1166016004172 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1166016004173 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1166016004174 active site 1166016004175 tetramer interface [polypeptide binding]; other site 1166016004176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016004177 active site 1166016004178 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1166016004179 Flavoprotein; Region: Flavoprotein; pfam02441 1166016004180 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1166016004181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016004182 substrate binding pocket [chemical binding]; other site 1166016004183 membrane-bound complex binding site; other site 1166016004184 hinge residues; other site 1166016004185 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016004186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016004187 dimer interface [polypeptide binding]; other site 1166016004188 conserved gate region; other site 1166016004189 putative PBP binding loops; other site 1166016004190 ABC-ATPase subunit interface; other site 1166016004191 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016004192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016004193 dimer interface [polypeptide binding]; other site 1166016004194 conserved gate region; other site 1166016004195 putative PBP binding loops; other site 1166016004196 ABC-ATPase subunit interface; other site 1166016004197 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1166016004198 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016004199 Walker A/P-loop; other site 1166016004200 ATP binding site [chemical binding]; other site 1166016004201 Q-loop/lid; other site 1166016004202 ABC transporter signature motif; other site 1166016004203 Walker B; other site 1166016004204 D-loop; other site 1166016004205 H-loop/switch region; other site 1166016004206 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1166016004207 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1166016004208 putative NAD(P) binding site [chemical binding]; other site 1166016004209 putative active site [active] 1166016004210 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1166016004211 homooctamer interface [polypeptide binding]; other site 1166016004212 active site 1166016004213 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1166016004214 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1166016004215 C-terminal domain interface [polypeptide binding]; other site 1166016004216 GSH binding site (G-site) [chemical binding]; other site 1166016004217 dimer interface [polypeptide binding]; other site 1166016004218 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1166016004219 N-terminal domain interface [polypeptide binding]; other site 1166016004220 putative dimer interface [polypeptide binding]; other site 1166016004221 active site 1166016004222 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1166016004223 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166016004224 active site 1166016004225 metal binding site [ion binding]; metal-binding site 1166016004226 homotetramer interface [polypeptide binding]; other site 1166016004227 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1166016004228 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1166016004229 nudix motif; other site 1166016004230 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1166016004231 phosphate acetyltransferase; Reviewed; Region: PRK05632 1166016004232 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166016004233 DRTGG domain; Region: DRTGG; pfam07085 1166016004234 phosphate acetyltransferase; Region: pta; TIGR00651 1166016004235 propionate/acetate kinase; Provisional; Region: PRK12379 1166016004236 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1166016004237 hypothetical protein; Provisional; Region: PRK01816 1166016004238 hypothetical protein; Validated; Region: PRK05445 1166016004239 putative phosphatase; Provisional; Region: PRK11587 1166016004240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016004241 motif II; other site 1166016004242 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1166016004243 transmembrane helices; other site 1166016004244 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166016004245 TrkA-C domain; Region: TrkA_C; pfam02080 1166016004246 TrkA-C domain; Region: TrkA_C; pfam02080 1166016004247 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1166016004248 5'-nucleotidase; Provisional; Region: PRK03826 1166016004249 aminotransferase AlaT; Validated; Region: PRK09265 1166016004250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016004251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016004252 homodimer interface [polypeptide binding]; other site 1166016004253 catalytic residue [active] 1166016004254 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1166016004255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016004256 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1166016004257 putative dimerization interface [polypeptide binding]; other site 1166016004258 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1166016004259 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1166016004260 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1166016004261 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1166016004262 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1166016004263 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1166016004264 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1166016004265 putative dimer interface [polypeptide binding]; other site 1166016004266 [2Fe-2S] cluster binding site [ion binding]; other site 1166016004267 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1166016004268 SLBB domain; Region: SLBB; pfam10531 1166016004269 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1166016004270 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1166016004271 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166016004272 catalytic loop [active] 1166016004273 iron binding site [ion binding]; other site 1166016004274 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1166016004275 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1166016004276 [4Fe-4S] binding site [ion binding]; other site 1166016004277 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1166016004278 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1166016004279 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1166016004280 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1166016004281 4Fe-4S binding domain; Region: Fer4; pfam00037 1166016004282 4Fe-4S binding domain; Region: Fer4; pfam00037 1166016004283 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1166016004284 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1166016004285 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1166016004286 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1166016004287 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1166016004288 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166016004289 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1166016004290 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166016004291 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1166016004292 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1166016004293 hypothetical protein; Provisional; Region: PRK10404 1166016004294 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1166016004295 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1166016004296 Ca binding site [ion binding]; other site 1166016004297 active site 1166016004298 catalytic site [active] 1166016004299 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1166016004300 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1166016004301 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016004302 active site turn [active] 1166016004303 phosphorylation site [posttranslational modification] 1166016004304 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016004305 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016004306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016004307 putative substrate translocation pore; other site 1166016004308 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1166016004309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016004310 FeS/SAM binding site; other site 1166016004311 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1166016004312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1166016004313 active site 1166016004314 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166016004315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166016004316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166016004317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166016004318 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1166016004319 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1166016004320 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1166016004321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016004322 Walker A/P-loop; other site 1166016004323 ATP binding site [chemical binding]; other site 1166016004324 Q-loop/lid; other site 1166016004325 ABC transporter signature motif; other site 1166016004326 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016004327 Walker B; other site 1166016004328 D-loop; other site 1166016004329 H-loop/switch region; other site 1166016004330 ABC transporter; Region: ABC_tran_2; pfam12848 1166016004331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016004332 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1166016004333 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016004334 N-terminal plug; other site 1166016004335 ligand-binding site [chemical binding]; other site 1166016004336 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 1166016004337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016004338 FeS/SAM binding site; other site 1166016004339 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 1166016004340 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1166016004341 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1166016004342 NAD(P) binding site [chemical binding]; other site 1166016004343 putative active site [active] 1166016004344 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1166016004345 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1166016004346 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1166016004347 catalytic triad [active] 1166016004348 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166016004349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016004350 DNA-binding site [nucleotide binding]; DNA binding site 1166016004351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016004352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016004353 homodimer interface [polypeptide binding]; other site 1166016004354 catalytic residue [active] 1166016004355 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1166016004356 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1166016004357 Domain of unknown function (DUF202); Region: DUF202; cl09954 1166016004358 Domain of unknown function (DUF202); Region: DUF202; cl09954 1166016004359 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166016004360 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166016004361 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166016004362 putative active site [active] 1166016004363 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1166016004364 active site 1166016004365 catalytic residues [active] 1166016004366 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1166016004367 Sulfatase; Region: Sulfatase; cl17466 1166016004368 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1166016004369 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016004370 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016004371 active site turn [active] 1166016004372 phosphorylation site [posttranslational modification] 1166016004373 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1166016004374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016004375 FeS/SAM binding site; other site 1166016004376 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1166016004377 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1166016004378 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1166016004379 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1166016004380 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1166016004381 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1166016004382 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166016004383 Phage Tail Collar Domain; Region: Collar; pfam07484 1166016004384 Nitrate and nitrite sensing; Region: NIT; pfam08376 1166016004385 ANTAR domain; Region: ANTAR; pfam03861 1166016004386 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1166016004387 NMT1-like family; Region: NMT1_2; pfam13379 1166016004388 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016004389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016004390 dimer interface [polypeptide binding]; other site 1166016004391 conserved gate region; other site 1166016004392 putative PBP binding loops; other site 1166016004393 ABC-ATPase subunit interface; other site 1166016004394 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1166016004395 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016004396 Walker A/P-loop; other site 1166016004397 ATP binding site [chemical binding]; other site 1166016004398 Q-loop/lid; other site 1166016004399 ABC transporter signature motif; other site 1166016004400 Walker B; other site 1166016004401 D-loop; other site 1166016004402 H-loop/switch region; other site 1166016004403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1166016004404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016004405 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1166016004406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016004407 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166016004408 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1166016004409 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1166016004410 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1166016004411 [4Fe-4S] binding site [ion binding]; other site 1166016004412 molybdopterin cofactor binding site; other site 1166016004413 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1166016004414 molybdopterin cofactor binding site; other site 1166016004415 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166016004416 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1166016004417 active site 1166016004418 SAM binding site [chemical binding]; other site 1166016004419 homodimer interface [polypeptide binding]; other site 1166016004420 hypothetical protein; Provisional; Region: PRK09956 1166016004421 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1166016004422 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1166016004423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1166016004424 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1166016004425 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1166016004426 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1166016004427 Cupin domain; Region: Cupin_2; cl17218 1166016004428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016004429 dimerization interface [polypeptide binding]; other site 1166016004430 putative DNA binding site [nucleotide binding]; other site 1166016004431 putative Zn2+ binding site [ion binding]; other site 1166016004432 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166016004433 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1166016004434 active site 1166016004435 FMN binding site [chemical binding]; other site 1166016004436 substrate binding site [chemical binding]; other site 1166016004437 homotetramer interface [polypeptide binding]; other site 1166016004438 catalytic residue [active] 1166016004439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1166016004440 SnoaL-like domain; Region: SnoaL_2; pfam12680 1166016004441 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1166016004442 galactonate dehydratase; Provisional; Region: PRK14017 1166016004443 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1166016004444 active site pocket [active] 1166016004445 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1166016004446 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1166016004447 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1166016004448 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1166016004449 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1166016004450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016004451 NAD(P) binding site [chemical binding]; other site 1166016004452 active site 1166016004453 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1166016004454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016004455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016004456 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1166016004457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016004458 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016004459 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1166016004460 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1166016004461 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016004462 DNA binding site [nucleotide binding] 1166016004463 active site 1166016004464 Int/Topo IB signature motif; other site 1166016004465 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016004466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016004467 anti-RssB factor; Provisional; Region: PRK10244 1166016004468 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1166016004469 hypothetical protein; Provisional; Region: PRK10613 1166016004470 response regulator; Provisional; Region: PRK09483 1166016004471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016004472 active site 1166016004473 phosphorylation site [posttranslational modification] 1166016004474 intermolecular recognition site; other site 1166016004475 dimerization interface [polypeptide binding]; other site 1166016004476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016004477 DNA binding residues [nucleotide binding] 1166016004478 dimerization interface [polypeptide binding]; other site 1166016004479 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1166016004480 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1166016004481 GIY-YIG motif/motif A; other site 1166016004482 active site 1166016004483 catalytic site [active] 1166016004484 putative DNA binding site [nucleotide binding]; other site 1166016004485 metal binding site [ion binding]; metal-binding site 1166016004486 UvrB/uvrC motif; Region: UVR; pfam02151 1166016004487 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1166016004488 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1166016004489 integrase; Provisional; Region: PRK09692 1166016004490 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016004491 active site 1166016004492 Int/Topo IB signature motif; other site 1166016004493 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1166016004494 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1166016004495 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016004496 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016004497 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016004498 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016004499 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1166016004500 PAAR motif; Region: PAAR_motif; pfam05488 1166016004501 RHS Repeat; Region: RHS_repeat; cl11982 1166016004502 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016004503 RHS Repeat; Region: RHS_repeat; pfam05593 1166016004504 RHS Repeat; Region: RHS_repeat; pfam05593 1166016004505 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166016004506 RHS Repeat; Region: RHS_repeat; cl11982 1166016004507 RHS Repeat; Region: RHS_repeat; cl11982 1166016004508 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016004509 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 1166016004510 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1166016004511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016004512 Walker A motif; other site 1166016004513 ATP binding site [chemical binding]; other site 1166016004514 Walker B motif; other site 1166016004515 arginine finger; other site 1166016004516 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1166016004517 Putative helicase; Region: TraI_2; pfam07514 1166016004518 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1166016004519 transposase/IS protein; Provisional; Region: PRK09183 1166016004520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016004521 Walker A motif; other site 1166016004522 ATP binding site [chemical binding]; other site 1166016004523 Walker B motif; other site 1166016004524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1166016004525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016004526 putative DNA binding site [nucleotide binding]; other site 1166016004527 putative Zn2+ binding site [ion binding]; other site 1166016004528 Integrase core domain; Region: rve; pfam00665 1166016004529 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 1166016004530 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1166016004531 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1166016004532 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1166016004533 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1166016004534 TIR domain; Region: TIR_2; pfam13676 1166016004535 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1166016004536 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1166016004537 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1166016004538 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1166016004539 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 1166016004540 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 1166016004541 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1166016004542 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1166016004543 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1166016004544 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1166016004545 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1166016004546 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1166016004547 Vacuolar protein sorting-associated protein 35; Region: Vps35; pfam03635 1166016004548 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1166016004549 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1166016004550 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1166016004551 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1166016004552 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016004553 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016004554 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1166016004555 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1166016004556 SEC-C motif; Region: SEC-C; pfam02810 1166016004557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016004558 nucleotide binding region [chemical binding]; other site 1166016004559 ATP-binding site [chemical binding]; other site 1166016004560 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1166016004561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016004562 ATP binding site [chemical binding]; other site 1166016004563 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1166016004564 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1166016004565 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1166016004566 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1166016004567 H-NS histone family; Region: Histone_HNS; pfam00816 1166016004568 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1166016004569 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1166016004570 Active Sites [active] 1166016004571 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1166016004572 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1166016004573 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1166016004574 cofactor binding site; other site 1166016004575 DNA binding site [nucleotide binding] 1166016004576 substrate interaction site [chemical binding]; other site 1166016004577 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1166016004578 DNA topoisomerase III; Provisional; Region: PRK07726 1166016004579 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1166016004580 active site 1166016004581 putative interdomain interaction site [polypeptide binding]; other site 1166016004582 putative metal-binding site [ion binding]; other site 1166016004583 putative nucleotide binding site [chemical binding]; other site 1166016004584 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1166016004585 domain I; other site 1166016004586 DNA binding groove [nucleotide binding] 1166016004587 phosphate binding site [ion binding]; other site 1166016004588 domain II; other site 1166016004589 domain III; other site 1166016004590 nucleotide binding site [chemical binding]; other site 1166016004591 catalytic site [active] 1166016004592 domain IV; other site 1166016004593 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016004594 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1166016004595 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1166016004596 NAD binding site [chemical binding]; other site 1166016004597 substrate binding site [chemical binding]; other site 1166016004598 putative active site [active] 1166016004599 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166016004600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016004601 dimerization interface [polypeptide binding]; other site 1166016004602 putative DNA binding site [nucleotide binding]; other site 1166016004603 putative Zn2+ binding site [ion binding]; other site 1166016004604 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1166016004605 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1166016004606 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1166016004607 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1166016004608 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1166016004609 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1166016004610 ParB-like nuclease domain; Region: ParBc; pfam02195 1166016004611 YcfA-like protein; Region: YcfA; cl00752 1166016004612 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1166016004613 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1166016004614 P-loop; other site 1166016004615 Magnesium ion binding site [ion binding]; other site 1166016004616 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1166016004617 Magnesium ion binding site [ion binding]; other site 1166016004618 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1166016004619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016004620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016004621 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1166016004622 dimerization interface [polypeptide binding]; other site 1166016004623 substrate binding pocket [chemical binding]; other site 1166016004624 integrase; Provisional; Region: PRK09692 1166016004625 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016004626 active site 1166016004627 Int/Topo IB signature motif; other site 1166016004628 Haemolysin expression modulating protein; Region: HHA; cl11501 1166016004629 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166016004630 PapC N-terminal domain; Region: PapC_N; pfam13954 1166016004631 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166016004632 PapC C-terminal domain; Region: PapC_C; pfam13953 1166016004633 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1166016004634 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166016004635 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166016004636 Bor protein; Region: Lambda_Bor; pfam06291 1166016004637 MASE1; Region: MASE1; cl17823 1166016004638 transcriptional regulator RcsB; Provisional; Region: PRK10840 1166016004639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016004640 active site 1166016004641 phosphorylation site [posttranslational modification] 1166016004642 intermolecular recognition site; other site 1166016004643 dimerization interface [polypeptide binding]; other site 1166016004644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016004645 DNA binding residues [nucleotide binding] 1166016004646 dimerization interface [polypeptide binding]; other site 1166016004647 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016004648 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1166016004649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016004650 putative active site [active] 1166016004651 heme pocket [chemical binding]; other site 1166016004652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016004653 dimer interface [polypeptide binding]; other site 1166016004654 phosphorylation site [posttranslational modification] 1166016004655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016004656 ATP binding site [chemical binding]; other site 1166016004657 Mg2+ binding site [ion binding]; other site 1166016004658 G-X-G motif; other site 1166016004659 Response regulator receiver domain; Region: Response_reg; pfam00072 1166016004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016004661 active site 1166016004662 phosphorylation site [posttranslational modification] 1166016004663 intermolecular recognition site; other site 1166016004664 dimerization interface [polypeptide binding]; other site 1166016004665 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1166016004666 putative binding surface; other site 1166016004667 active site 1166016004668 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1166016004669 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1166016004670 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1166016004671 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1166016004672 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1166016004673 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1166016004674 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1166016004675 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1166016004676 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166016004677 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016004678 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1166016004679 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1166016004680 Walker A motif; other site 1166016004681 ATP binding site [chemical binding]; other site 1166016004682 Walker B motif; other site 1166016004683 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1166016004684 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016004685 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016004686 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1166016004687 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016004688 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016004689 catalytic residue [active] 1166016004690 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1166016004691 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1166016004692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166016004693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016004694 active site 1166016004695 phosphorylation site [posttranslational modification] 1166016004696 intermolecular recognition site; other site 1166016004697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016004698 DNA binding residues [nucleotide binding] 1166016004699 dimerization interface [polypeptide binding]; other site 1166016004700 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1166016004701 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 1166016004702 active site 1166016004703 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1166016004704 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1166016004705 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1166016004706 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1166016004707 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1166016004708 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1166016004709 active site 1166016004710 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1166016004711 Interdomain contacts; other site 1166016004712 Cytokine receptor motif; other site 1166016004713 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1166016004714 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1166016004715 Interdomain contacts; other site 1166016004716 Cytokine receptor motif; other site 1166016004717 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1166016004718 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1166016004719 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1166016004720 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1166016004721 Fimbrial protein; Region: Fimbrial; cl01416 1166016004722 excinuclease ABC subunit B; Provisional; Region: PRK05298 1166016004723 PapC N-terminal domain; Region: PapC_N; pfam13954 1166016004724 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166016004725 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166016004726 PapC C-terminal domain; Region: PapC_C; pfam13953 1166016004727 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166016004728 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166016004729 Fimbrial protein; Region: Fimbrial; pfam00419 1166016004730 Fimbrial protein; Region: Fimbrial; cl01416 1166016004731 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1166016004732 YadA-like C-terminal region; Region: YadA; pfam03895 1166016004733 short chain dehydrogenase; Provisional; Region: PRK06500 1166016004734 classical (c) SDRs; Region: SDR_c; cd05233 1166016004735 NAD(P) binding site [chemical binding]; other site 1166016004736 active site 1166016004737 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1166016004738 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1166016004739 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1166016004740 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1166016004741 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166016004742 PapC N-terminal domain; Region: PapC_N; pfam13954 1166016004743 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166016004744 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1166016004745 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1166016004746 PapC C-terminal domain; Region: PapC_C; pfam13953 1166016004747 Fimbrial protein; Region: Fimbrial; cl01416 1166016004748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016004749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016004750 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166016004751 putative effector binding pocket; other site 1166016004752 dimerization interface [polypeptide binding]; other site 1166016004753 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1166016004754 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1166016004755 catalytic residues [active] 1166016004756 hinge region; other site 1166016004757 alpha helical domain; other site 1166016004758 HTH-like domain; Region: HTH_21; pfam13276 1166016004759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016004760 Integrase core domain; Region: rve; pfam00665 1166016004761 Integrase core domain; Region: rve_3; pfam13683 1166016004762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016004763 Transposase; Region: HTH_Tnp_1; pfam01527 1166016004764 Uncharacterized conserved protein [Function unknown]; Region: COG4104 1166016004765 S-type Pyocin; Region: Pyocin_S; pfam06958 1166016004766 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1166016004767 SEFIR domain; Region: SEFIR; pfam08357 1166016004768 integrase; Provisional; Region: PRK09692 1166016004769 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016004770 active site 1166016004771 Int/Topo IB signature motif; other site 1166016004772 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1166016004773 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1166016004774 cofactor binding site; other site 1166016004775 DNA binding site [nucleotide binding] 1166016004776 substrate interaction site [chemical binding]; other site 1166016004777 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1166016004778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016004779 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1166016004780 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1166016004781 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1166016004782 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1166016004783 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1166016004784 CcdB protein; Region: CcdB; pfam01845 1166016004785 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1166016004786 TrbM; Region: TrbM; pfam07424 1166016004787 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1166016004788 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1166016004789 Walker A motif; other site 1166016004790 hexamer interface [polypeptide binding]; other site 1166016004791 ATP binding site [chemical binding]; other site 1166016004792 Walker B motif; other site 1166016004793 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1166016004794 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1166016004795 VirB7 interaction site; other site 1166016004796 VirB8 protein; Region: VirB8; pfam04335 1166016004797 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1166016004798 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1166016004799 Type IV secretion system proteins; Region: T4SS; pfam07996 1166016004800 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1166016004801 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1166016004802 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1166016004803 TrbC/VIRB2 family; Region: TrbC; pfam04956 1166016004804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016004805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016004806 catalytic residue [active] 1166016004807 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 1166016004808 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1166016004809 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166016004810 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1166016004811 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166016004812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016004813 non-specific DNA binding site [nucleotide binding]; other site 1166016004814 salt bridge; other site 1166016004815 sequence-specific DNA binding site [nucleotide binding]; other site 1166016004816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166016004817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016004818 non-specific DNA binding site [nucleotide binding]; other site 1166016004819 salt bridge; other site 1166016004820 sequence-specific DNA binding site [nucleotide binding]; other site 1166016004821 integrase; Provisional; Region: PRK09692 1166016004822 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016004823 active site 1166016004824 Int/Topo IB signature motif; other site 1166016004825 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166016004826 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1166016004827 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1166016004828 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1166016004829 active site 1166016004830 catalytic residues [active] 1166016004831 Int/Topo IB signature motif; other site 1166016004832 DNA binding site [nucleotide binding] 1166016004833 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1166016004834 active site 1166016004835 Int/Topo IB signature motif; other site 1166016004836 catalytic residues [active] 1166016004837 DNA binding site [nucleotide binding] 1166016004838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1166016004839 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1166016004840 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1166016004841 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1166016004842 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016004843 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 1166016004844 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1166016004845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016004846 AAA domain; Region: AAA_21; pfam13304 1166016004847 Walker A/P-loop; other site 1166016004848 ATP binding site [chemical binding]; other site 1166016004849 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1166016004850 putative active site [active] 1166016004851 putative metal-binding site [ion binding]; other site 1166016004852 Part of AAA domain; Region: AAA_19; pfam13245 1166016004853 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1166016004854 Family description; Region: UvrD_C_2; pfam13538 1166016004855 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1166016004856 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1166016004857 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1166016004858 Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and...; Region: KR; cl00100 1166016004859 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016004860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016004861 ABC transporter signature motif; other site 1166016004862 Walker B; other site 1166016004863 D-loop; other site 1166016004864 H-loop/switch region; other site 1166016004865 Protein of unknown function (DUF867); Region: DUF867; cl01713 1166016004866 integrase; Provisional; Region: PRK09692 1166016004867 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016004868 active site 1166016004869 Int/Topo IB signature motif; other site 1166016004870 galactoside permease; Reviewed; Region: lacY; PRK09528 1166016004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016004872 putative substrate translocation pore; other site 1166016004873 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1166016004874 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1166016004875 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1166016004876 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1166016004877 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1166016004878 lac repressor; Reviewed; Region: lacI; PRK09526 1166016004879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016004880 DNA binding site [nucleotide binding] 1166016004881 domain linker motif; other site 1166016004882 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1166016004883 ligand binding site [chemical binding]; other site 1166016004884 dimerization interface (open form) [polypeptide binding]; other site 1166016004885 dimerization interface (closed form) [polypeptide binding]; other site 1166016004886 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 1166016004887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016004888 Walker A/P-loop; other site 1166016004889 ATP binding site [chemical binding]; other site 1166016004890 Q-loop/lid; other site 1166016004891 ABC transporter signature motif; other site 1166016004892 Walker B; other site 1166016004893 D-loop; other site 1166016004894 H-loop/switch region; other site 1166016004895 TOBE domain; Region: TOBE_2; pfam08402 1166016004896 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166016004897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016004898 dimer interface [polypeptide binding]; other site 1166016004899 conserved gate region; other site 1166016004900 putative PBP binding loops; other site 1166016004901 ABC-ATPase subunit interface; other site 1166016004902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016004903 dimer interface [polypeptide binding]; other site 1166016004904 conserved gate region; other site 1166016004905 putative PBP binding loops; other site 1166016004906 ABC-ATPase subunit interface; other site 1166016004907 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1166016004908 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166016004909 regulatory protein UhpC; Provisional; Region: PRK11663 1166016004910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016004911 putative substrate translocation pore; other site 1166016004912 MASE1; Region: MASE1; pfam05231 1166016004913 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 1166016004914 Histidine kinase; Region: HisKA_3; pfam07730 1166016004915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016004916 ATP binding site [chemical binding]; other site 1166016004917 Mg2+ binding site [ion binding]; other site 1166016004918 G-X-G motif; other site 1166016004919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1166016004920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016004921 active site 1166016004922 phosphorylation site [posttranslational modification] 1166016004923 intermolecular recognition site; other site 1166016004924 dimerization interface [polypeptide binding]; other site 1166016004925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016004926 DNA binding residues [nucleotide binding] 1166016004927 dimerization interface [polypeptide binding]; other site 1166016004928 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1166016004929 lipoprotein, YaeC family; Region: TIGR00363 1166016004930 Pectate lyase; Region: Pec_lyase_C; cl01593 1166016004931 aspartate racemase; Region: asp_race; TIGR00035 1166016004932 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1166016004933 cell density-dependent motility repressor; Provisional; Region: PRK10082 1166016004934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016004935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016004936 dimerization interface [polypeptide binding]; other site 1166016004937 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166016004938 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1166016004939 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1166016004940 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1166016004941 [4Fe-4S] binding site [ion binding]; other site 1166016004942 molybdopterin cofactor binding site; other site 1166016004943 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1166016004944 molybdopterin cofactor binding site; other site 1166016004945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016004946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016004947 dimer interface [polypeptide binding]; other site 1166016004948 putative CheW interface [polypeptide binding]; other site 1166016004949 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1166016004950 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 1166016004951 Predicted membrane protein [Function unknown]; Region: COG4393 1166016004952 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1166016004953 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1166016004954 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166016004955 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1166016004956 FtsX-like permease family; Region: FtsX; pfam02687 1166016004957 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1166016004958 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166016004959 FtsX-like permease family; Region: FtsX; pfam02687 1166016004960 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166016004961 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166016004962 Walker A/P-loop; other site 1166016004963 ATP binding site [chemical binding]; other site 1166016004964 Q-loop/lid; other site 1166016004965 ABC transporter signature motif; other site 1166016004966 Walker B; other site 1166016004967 D-loop; other site 1166016004968 H-loop/switch region; other site 1166016004969 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1166016004970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1166016004971 catalytic residues [active] 1166016004972 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166016004973 EamA-like transporter family; Region: EamA; pfam00892 1166016004974 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016004975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016004976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016004977 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1166016004978 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1166016004979 substrate binding site [chemical binding]; other site 1166016004980 dimerization interface [polypeptide binding]; other site 1166016004981 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1166016004982 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166016004983 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1166016004984 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1166016004985 putative active site [active] 1166016004986 metal binding site [ion binding]; metal-binding site 1166016004987 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016004988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016004989 putative PBP binding loops; other site 1166016004990 dimer interface [polypeptide binding]; other site 1166016004991 ABC-ATPase subunit interface; other site 1166016004992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166016004993 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016004994 Walker A/P-loop; other site 1166016004995 ATP binding site [chemical binding]; other site 1166016004996 Q-loop/lid; other site 1166016004997 ABC transporter signature motif; other site 1166016004998 Walker B; other site 1166016004999 D-loop; other site 1166016005000 H-loop/switch region; other site 1166016005001 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1166016005002 NMT1-like family; Region: NMT1_2; pfam13379 1166016005003 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1166016005004 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1166016005005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016005006 substrate binding pocket [chemical binding]; other site 1166016005007 membrane-bound complex binding site; other site 1166016005008 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016005009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005010 dimer interface [polypeptide binding]; other site 1166016005011 conserved gate region; other site 1166016005012 putative PBP binding loops; other site 1166016005013 ABC-ATPase subunit interface; other site 1166016005014 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1166016005015 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016005016 Walker A/P-loop; other site 1166016005017 ATP binding site [chemical binding]; other site 1166016005018 Q-loop/lid; other site 1166016005019 ABC transporter signature motif; other site 1166016005020 Walker B; other site 1166016005021 D-loop; other site 1166016005022 H-loop/switch region; other site 1166016005023 D-cysteine desulfhydrase; Validated; Region: PRK03910 1166016005024 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1166016005025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016005026 catalytic residue [active] 1166016005027 aspartate racemase; Region: asp_race; TIGR00035 1166016005028 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1166016005029 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016005030 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016005031 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1166016005032 Lysis protein; Region: Lysis_col; pfam02402 1166016005033 PAAR motif; Region: PAAR_motif; pfam05488 1166016005034 Integrase core domain; Region: rve_3; cl15866 1166016005035 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1166016005036 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1166016005037 Secretin and TonB N terminus short domain; Region: STN; smart00965 1166016005038 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1166016005039 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016005040 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1166016005041 FecR protein; Region: FecR; pfam04773 1166016005042 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1166016005043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016005044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016005045 DNA binding residues [nucleotide binding] 1166016005046 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1166016005047 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1166016005048 tetrameric interface [polypeptide binding]; other site 1166016005049 NAD binding site [chemical binding]; other site 1166016005050 catalytic residues [active] 1166016005051 substrate binding site [chemical binding]; other site 1166016005052 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1166016005053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016005054 inhibitor-cofactor binding pocket; inhibition site 1166016005055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016005056 catalytic residue [active] 1166016005057 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016005058 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016005059 HAMP domain; Region: HAMP; pfam00672 1166016005060 dimerization interface [polypeptide binding]; other site 1166016005061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016005062 dimer interface [polypeptide binding]; other site 1166016005063 putative CheW interface [polypeptide binding]; other site 1166016005064 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1166016005065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016005066 S-adenosylmethionine binding site [chemical binding]; other site 1166016005067 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016005068 AMP nucleosidase; Provisional; Region: PRK08292 1166016005069 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1166016005070 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1166016005071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166016005072 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166016005073 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1166016005074 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1166016005075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016005076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016005077 putative substrate translocation pore; other site 1166016005078 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1166016005079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016005080 Walker A/P-loop; other site 1166016005081 ATP binding site [chemical binding]; other site 1166016005082 Q-loop/lid; other site 1166016005083 ABC transporter signature motif; other site 1166016005084 Walker B; other site 1166016005085 D-loop; other site 1166016005086 H-loop/switch region; other site 1166016005087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016005088 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1166016005089 Walker A/P-loop; other site 1166016005090 ATP binding site [chemical binding]; other site 1166016005091 Q-loop/lid; other site 1166016005092 ABC transporter signature motif; other site 1166016005093 Walker B; other site 1166016005094 D-loop; other site 1166016005095 H-loop/switch region; other site 1166016005096 hypothetical protein; Provisional; Region: PRK09956 1166016005097 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1166016005098 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1166016005099 catalytic residues [active] 1166016005100 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1166016005101 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016005102 Walker A/P-loop; other site 1166016005103 ATP binding site [chemical binding]; other site 1166016005104 Q-loop/lid; other site 1166016005105 ABC transporter signature motif; other site 1166016005106 Walker B; other site 1166016005107 D-loop; other site 1166016005108 H-loop/switch region; other site 1166016005109 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016005110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005111 dimer interface [polypeptide binding]; other site 1166016005112 conserved gate region; other site 1166016005113 putative PBP binding loops; other site 1166016005114 ABC-ATPase subunit interface; other site 1166016005115 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016005116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005117 dimer interface [polypeptide binding]; other site 1166016005118 conserved gate region; other site 1166016005119 putative PBP binding loops; other site 1166016005120 ABC-ATPase subunit interface; other site 1166016005121 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1166016005122 NMT1-like family; Region: NMT1_2; pfam13379 1166016005123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016005124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016005125 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1166016005126 dimerization interface [polypeptide binding]; other site 1166016005127 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1166016005128 transcriptional regulator TraR; Provisional; Region: PRK13870 1166016005129 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1166016005130 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016005131 DNA binding residues [nucleotide binding] 1166016005132 dimerization interface [polypeptide binding]; other site 1166016005133 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1166016005134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016005135 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1166016005136 active site 1166016005137 phosphorylation site [posttranslational modification] 1166016005138 intermolecular recognition site; other site 1166016005139 dimerization interface [polypeptide binding]; other site 1166016005140 outer membrane receptor FepA; Provisional; Region: PRK13528 1166016005141 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016005142 N-terminal plug; other site 1166016005143 ligand-binding site [chemical binding]; other site 1166016005144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016005145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016005146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1166016005147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016005148 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1166016005149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016005150 putative substrate translocation pore; other site 1166016005151 putative S-transferase; Provisional; Region: PRK11752 1166016005152 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1166016005153 C-terminal domain interface [polypeptide binding]; other site 1166016005154 GSH binding site (G-site) [chemical binding]; other site 1166016005155 dimer interface [polypeptide binding]; other site 1166016005156 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1166016005157 dimer interface [polypeptide binding]; other site 1166016005158 N-terminal domain interface [polypeptide binding]; other site 1166016005159 active site 1166016005160 hypothetical protein; Provisional; Region: PRK06815 1166016005161 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1166016005162 tetramer interface [polypeptide binding]; other site 1166016005163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016005164 catalytic residue [active] 1166016005165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016005166 dimerization interface [polypeptide binding]; other site 1166016005167 putative DNA binding site [nucleotide binding]; other site 1166016005168 putative Zn2+ binding site [ion binding]; other site 1166016005169 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1166016005170 heme-binding site [chemical binding]; other site 1166016005171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016005172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016005173 metal binding site [ion binding]; metal-binding site 1166016005174 active site 1166016005175 I-site; other site 1166016005176 hypothetical protein; Provisional; Region: PRK10708 1166016005177 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166016005178 ligand binding site [chemical binding]; other site 1166016005179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016005180 dimerization interface [polypeptide binding]; other site 1166016005181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016005182 dimer interface [polypeptide binding]; other site 1166016005183 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016005184 putative CheW interface [polypeptide binding]; other site 1166016005185 EamA-like transporter family; Region: EamA; pfam00892 1166016005186 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1166016005187 EamA-like transporter family; Region: EamA; pfam00892 1166016005188 transcriptional activator FlhD; Provisional; Region: PRK02909 1166016005189 transcriptional activator FlhC; Provisional; Region: PRK12722 1166016005190 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1166016005191 flagellar motor protein MotA; Validated; Region: PRK09110 1166016005192 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1166016005193 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1166016005194 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166016005195 ligand binding site [chemical binding]; other site 1166016005196 chemotaxis protein CheA; Provisional; Region: PRK10547 1166016005197 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166016005198 putative binding surface; other site 1166016005199 active site 1166016005200 CheY binding; Region: CheY-binding; pfam09078 1166016005201 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1166016005202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016005203 ATP binding site [chemical binding]; other site 1166016005204 Mg2+ binding site [ion binding]; other site 1166016005205 G-X-G motif; other site 1166016005206 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1166016005207 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1166016005208 putative CheA interaction surface; other site 1166016005209 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166016005210 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166016005211 dimer interface [polypeptide binding]; other site 1166016005212 ligand binding site [chemical binding]; other site 1166016005213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016005214 dimerization interface [polypeptide binding]; other site 1166016005215 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016005216 dimer interface [polypeptide binding]; other site 1166016005217 putative CheW interface [polypeptide binding]; other site 1166016005218 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1166016005219 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1166016005220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016005221 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1166016005222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016005223 active site 1166016005224 phosphorylation site [posttranslational modification] 1166016005225 intermolecular recognition site; other site 1166016005226 dimerization interface [polypeptide binding]; other site 1166016005227 CheB methylesterase; Region: CheB_methylest; pfam01339 1166016005228 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1166016005229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016005230 active site 1166016005231 phosphorylation site [posttranslational modification] 1166016005232 intermolecular recognition site; other site 1166016005233 dimerization interface [polypeptide binding]; other site 1166016005234 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1166016005235 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 1166016005236 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1166016005237 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1166016005238 FHIPEP family; Region: FHIPEP; pfam00771 1166016005239 Flagellar protein FlhE; Region: FlhE; pfam06366 1166016005240 Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418 1166016005241 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1166016005242 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1166016005243 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1166016005244 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1166016005245 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1166016005246 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1166016005247 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1166016005248 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166016005249 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166016005250 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1166016005251 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1166016005252 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1166016005253 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1166016005254 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166016005255 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1166016005256 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166016005257 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1166016005258 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166016005259 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166016005260 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1166016005261 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1166016005262 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166016005263 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1166016005264 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1166016005265 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1166016005266 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1166016005267 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1166016005268 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1166016005269 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1166016005270 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1166016005271 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1166016005272 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1166016005273 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166016005274 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1166016005275 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1166016005276 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1166016005277 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1166016005278 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1166016005279 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1166016005280 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1166016005281 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1166016005282 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1166016005283 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1166016005284 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1166016005285 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1166016005286 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1166016005287 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1166016005288 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1166016005289 Walker A motif/ATP binding site; other site 1166016005290 Walker B motif; other site 1166016005291 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1166016005292 Flagellar assembly protein FliH; Region: FliH; pfam02108 1166016005293 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1166016005294 FliG C-terminal domain; Region: FliG_C; pfam01706 1166016005295 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1166016005296 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1166016005297 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1166016005298 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1166016005299 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1166016005300 flagellar protein FliS; Validated; Region: fliS; PRK05685 1166016005301 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1166016005302 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1166016005303 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1166016005304 flagellin; Validated; Region: PRK06819 1166016005305 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1166016005306 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1166016005307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016005308 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166016005309 S-adenosylmethionine binding site [chemical binding]; other site 1166016005310 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1166016005311 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 1166016005312 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1166016005313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016005314 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166016005315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016005316 DNA binding residues [nucleotide binding] 1166016005317 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1166016005318 hypothetical protein; Provisional; Region: PRK10536 1166016005319 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1166016005320 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016005321 DNA binding site [nucleotide binding] 1166016005322 Int/Topo IB signature motif; other site 1166016005323 active site 1166016005324 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016005325 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166016005326 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016005327 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1166016005328 active site 1166016005329 Int/Topo IB signature motif; other site 1166016005330 catalytic residues [active] 1166016005331 DNA binding site [nucleotide binding] 1166016005332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1166016005333 AAA domain; Region: AAA_21; pfam13304 1166016005334 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1166016005335 META domain; Region: META; cl01245 1166016005336 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1166016005337 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1166016005338 ParB-like nuclease domain; Region: ParBc; cl02129 1166016005339 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1166016005340 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1166016005341 HicB family; Region: HicB; pfam05534 1166016005342 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016005343 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1166016005344 integrase; Provisional; Region: PRK09692 1166016005345 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016005346 active site 1166016005347 Int/Topo IB signature motif; other site 1166016005348 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1166016005349 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1166016005350 Sulfatase; Region: Sulfatase; cl17466 1166016005351 hypothetical protein; Provisional; Region: PRK13689 1166016005352 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1166016005353 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1166016005354 Predicted membrane protein [Function unknown]; Region: COG3503 1166016005355 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1166016005356 5S rRNA interface [nucleotide binding]; other site 1166016005357 CTC domain interface [polypeptide binding]; other site 1166016005358 L16 interface [polypeptide binding]; other site 1166016005359 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1166016005360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016005361 ATP binding site [chemical binding]; other site 1166016005362 putative Mg++ binding site [ion binding]; other site 1166016005363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016005364 nucleotide binding region [chemical binding]; other site 1166016005365 ATP-binding site [chemical binding]; other site 1166016005366 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1166016005367 probable metal-binding protein; Region: matur_matur; TIGR03853 1166016005368 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1166016005369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016005370 RNA binding surface [nucleotide binding]; other site 1166016005371 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1166016005372 active site 1166016005373 uracil binding [chemical binding]; other site 1166016005374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016005375 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1166016005376 putative substrate translocation pore; other site 1166016005377 hypothetical protein; Provisional; Region: PRK11835 1166016005378 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1166016005379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016005380 Walker A/P-loop; other site 1166016005381 ATP binding site [chemical binding]; other site 1166016005382 Q-loop/lid; other site 1166016005383 ABC transporter signature motif; other site 1166016005384 Walker B; other site 1166016005385 D-loop; other site 1166016005386 H-loop/switch region; other site 1166016005387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016005388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016005389 Walker A/P-loop; other site 1166016005390 ATP binding site [chemical binding]; other site 1166016005391 Q-loop/lid; other site 1166016005392 ABC transporter signature motif; other site 1166016005393 Walker B; other site 1166016005394 D-loop; other site 1166016005395 H-loop/switch region; other site 1166016005396 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1166016005397 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166016005398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005399 dimer interface [polypeptide binding]; other site 1166016005400 conserved gate region; other site 1166016005401 putative PBP binding loops; other site 1166016005402 ABC-ATPase subunit interface; other site 1166016005403 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1166016005404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005405 dimer interface [polypeptide binding]; other site 1166016005406 conserved gate region; other site 1166016005407 putative PBP binding loops; other site 1166016005408 ABC-ATPase subunit interface; other site 1166016005409 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1166016005410 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1166016005411 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1166016005412 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166016005413 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1166016005414 active site 1166016005415 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1166016005416 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1166016005417 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1166016005418 elongation factor P; Provisional; Region: PRK04542 1166016005419 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1166016005420 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1166016005421 RNA binding site [nucleotide binding]; other site 1166016005422 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1166016005423 RNA binding site [nucleotide binding]; other site 1166016005424 sugar efflux transporter B; Provisional; Region: PRK15011 1166016005425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016005426 putative substrate translocation pore; other site 1166016005427 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1166016005428 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016005429 active site 1166016005430 phosphorylation site [posttranslational modification] 1166016005431 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1166016005432 dimerization domain swap beta strand [polypeptide binding]; other site 1166016005433 regulatory protein interface [polypeptide binding]; other site 1166016005434 active site 1166016005435 regulatory phosphorylation site [posttranslational modification]; other site 1166016005436 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1166016005437 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1166016005438 putative substrate binding site [chemical binding]; other site 1166016005439 putative ATP binding site [chemical binding]; other site 1166016005440 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1166016005441 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1166016005442 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1166016005443 active site 1166016005444 P-loop; other site 1166016005445 phosphorylation site [posttranslational modification] 1166016005446 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1166016005447 endonuclease IV; Provisional; Region: PRK01060 1166016005448 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1166016005449 AP (apurinic/apyrimidinic) site pocket; other site 1166016005450 DNA interaction; other site 1166016005451 Metal-binding active site; metal-binding site 1166016005452 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1166016005453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016005454 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1166016005455 putative dimerization interface [polypeptide binding]; other site 1166016005456 lysine transporter; Provisional; Region: PRK10836 1166016005457 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 1166016005458 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016005459 N-terminal plug; other site 1166016005460 ligand-binding site [chemical binding]; other site 1166016005461 glycerate dehydrogenase; Provisional; Region: PRK06932 1166016005462 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1166016005463 putative ligand binding site [chemical binding]; other site 1166016005464 putative NAD binding site [chemical binding]; other site 1166016005465 catalytic site [active] 1166016005466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016005467 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016005468 TM-ABC transporter signature motif; other site 1166016005469 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166016005470 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016005471 Walker A/P-loop; other site 1166016005472 ATP binding site [chemical binding]; other site 1166016005473 Q-loop/lid; other site 1166016005474 ABC transporter signature motif; other site 1166016005475 Walker B; other site 1166016005476 D-loop; other site 1166016005477 H-loop/switch region; other site 1166016005478 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016005479 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1166016005480 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1166016005481 putative active site [active] 1166016005482 metal binding site [ion binding]; metal-binding site 1166016005483 KTSC domain; Region: KTSC; pfam13619 1166016005484 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166016005485 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1166016005486 putative C-terminal domain interface [polypeptide binding]; other site 1166016005487 putative GSH binding site (G-site) [chemical binding]; other site 1166016005488 putative dimer interface [polypeptide binding]; other site 1166016005489 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1166016005490 putative N-terminal domain interface [polypeptide binding]; other site 1166016005491 putative dimer interface [polypeptide binding]; other site 1166016005492 putative substrate binding pocket (H-site) [chemical binding]; other site 1166016005493 S-formylglutathione hydrolase; Region: PLN02442 1166016005494 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1166016005495 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1166016005496 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1166016005497 substrate binding site [chemical binding]; other site 1166016005498 catalytic Zn binding site [ion binding]; other site 1166016005499 NAD binding site [chemical binding]; other site 1166016005500 structural Zn binding site [ion binding]; other site 1166016005501 dimer interface [polypeptide binding]; other site 1166016005502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016005503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016005504 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1166016005505 putative dimerization interface [polypeptide binding]; other site 1166016005506 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1166016005507 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016005508 dimer interface [polypeptide binding]; other site 1166016005509 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016005510 putative CheW interface [polypeptide binding]; other site 1166016005511 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1166016005512 active site 1166016005513 Predicted membrane protein [Function unknown]; Region: COG2311 1166016005514 hypothetical protein; Provisional; Region: PRK10835 1166016005515 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1166016005516 putative active site [active] 1166016005517 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1166016005518 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1166016005519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016005520 FeS/SAM binding site; other site 1166016005521 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1166016005522 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1166016005523 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166016005524 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1166016005525 putative C-terminal domain interface [polypeptide binding]; other site 1166016005526 putative GSH binding site (G-site) [chemical binding]; other site 1166016005527 putative dimer interface [polypeptide binding]; other site 1166016005528 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1166016005529 putative N-terminal domain interface [polypeptide binding]; other site 1166016005530 putative dimer interface [polypeptide binding]; other site 1166016005531 putative substrate binding pocket (H-site) [chemical binding]; other site 1166016005532 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1166016005533 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1166016005534 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1166016005535 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1166016005536 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1166016005537 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1166016005538 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166016005539 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016005540 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1166016005541 intersubunit interface [polypeptide binding]; other site 1166016005542 active site 1166016005543 catalytic residue [active] 1166016005544 putative transporter; Provisional; Region: PRK04972 1166016005545 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1166016005546 TrkA-C domain; Region: TrkA_C; pfam02080 1166016005547 TrkA-C domain; Region: TrkA_C; pfam02080 1166016005548 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1166016005549 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1166016005550 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1166016005551 GSH binding site [chemical binding]; other site 1166016005552 catalytic residues [active] 1166016005553 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1166016005554 dimer interface [polypeptide binding]; other site 1166016005555 FMN binding site [chemical binding]; other site 1166016005556 NADPH bind site [chemical binding]; other site 1166016005557 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1166016005558 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1166016005559 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1166016005560 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1166016005561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166016005562 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1166016005563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016005564 Walker A/P-loop; other site 1166016005565 ATP binding site [chemical binding]; other site 1166016005566 Q-loop/lid; other site 1166016005567 ABC transporter signature motif; other site 1166016005568 Walker B; other site 1166016005569 D-loop; other site 1166016005570 H-loop/switch region; other site 1166016005571 TOBE domain; Region: TOBE_2; pfam08402 1166016005572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005573 dimer interface [polypeptide binding]; other site 1166016005574 conserved gate region; other site 1166016005575 putative PBP binding loops; other site 1166016005576 ABC-ATPase subunit interface; other site 1166016005577 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016005578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005579 dimer interface [polypeptide binding]; other site 1166016005580 conserved gate region; other site 1166016005581 putative PBP binding loops; other site 1166016005582 ABC-ATPase subunit interface; other site 1166016005583 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1166016005584 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1166016005585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016005586 S-adenosylmethionine binding site [chemical binding]; other site 1166016005587 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1166016005588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016005589 substrate binding pocket [chemical binding]; other site 1166016005590 membrane-bound complex binding site; other site 1166016005591 hinge residues; other site 1166016005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005593 dimer interface [polypeptide binding]; other site 1166016005594 conserved gate region; other site 1166016005595 putative PBP binding loops; other site 1166016005596 ABC-ATPase subunit interface; other site 1166016005597 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016005598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016005599 dimer interface [polypeptide binding]; other site 1166016005600 conserved gate region; other site 1166016005601 putative PBP binding loops; other site 1166016005602 ABC-ATPase subunit interface; other site 1166016005603 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1166016005604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016005605 substrate binding pocket [chemical binding]; other site 1166016005606 membrane-bound complex binding site; other site 1166016005607 hinge residues; other site 1166016005608 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1166016005609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016005610 Walker A/P-loop; other site 1166016005611 ATP binding site [chemical binding]; other site 1166016005612 Q-loop/lid; other site 1166016005613 ABC transporter signature motif; other site 1166016005614 Walker B; other site 1166016005615 D-loop; other site 1166016005616 H-loop/switch region; other site 1166016005617 hypothetical protein; Provisional; Region: PRK02877 1166016005618 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1166016005619 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1166016005620 amidase catalytic site [active] 1166016005621 Zn binding residues [ion binding]; other site 1166016005622 substrate binding site [chemical binding]; other site 1166016005623 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1166016005624 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1166016005625 putative NAD(P) binding site [chemical binding]; other site 1166016005626 putative active site [active] 1166016005627 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1166016005628 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1166016005629 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1166016005630 FAD binding pocket [chemical binding]; other site 1166016005631 FAD binding motif [chemical binding]; other site 1166016005632 phosphate binding motif [ion binding]; other site 1166016005633 beta-alpha-beta structure motif; other site 1166016005634 NAD binding pocket [chemical binding]; other site 1166016005635 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166016005636 catalytic loop [active] 1166016005637 iron binding site [ion binding]; other site 1166016005638 hybrid cluster protein; Provisional; Region: PRK05290 1166016005639 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016005640 ACS interaction site; other site 1166016005641 CODH interaction site; other site 1166016005642 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1166016005643 hybrid metal cluster; other site 1166016005644 Predicted membrane protein [Function unknown]; Region: COG2431 1166016005645 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1166016005646 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1166016005647 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1166016005648 putative active site [active] 1166016005649 putative metal-binding site [ion binding]; other site 1166016005650 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166016005651 DNA-binding site [nucleotide binding]; DNA binding site 1166016005652 RNA-binding motif; other site 1166016005653 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1166016005654 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1166016005655 Clp amino terminal domain; Region: Clp_N; pfam02861 1166016005656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016005657 Walker A motif; other site 1166016005658 ATP binding site [chemical binding]; other site 1166016005659 Walker B motif; other site 1166016005660 arginine finger; other site 1166016005661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016005662 Walker A motif; other site 1166016005663 ATP binding site [chemical binding]; other site 1166016005664 Walker B motif; other site 1166016005665 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1166016005666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166016005667 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1166016005668 putative dimer interface [polypeptide binding]; other site 1166016005669 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1166016005670 rRNA binding site [nucleotide binding]; other site 1166016005671 predicted 30S ribosome binding site; other site 1166016005672 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1166016005673 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1166016005674 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016005675 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1166016005676 Walker A/P-loop; other site 1166016005677 ATP binding site [chemical binding]; other site 1166016005678 Q-loop/lid; other site 1166016005679 ABC transporter signature motif; other site 1166016005680 Walker B; other site 1166016005681 D-loop; other site 1166016005682 H-loop/switch region; other site 1166016005683 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1166016005684 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016005685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016005686 Walker A/P-loop; other site 1166016005687 ATP binding site [chemical binding]; other site 1166016005688 Q-loop/lid; other site 1166016005689 ABC transporter signature motif; other site 1166016005690 Walker B; other site 1166016005691 D-loop; other site 1166016005692 H-loop/switch region; other site 1166016005693 thioredoxin reductase; Provisional; Region: PRK10262 1166016005694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016005695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016005696 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1166016005697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016005698 putative DNA binding site [nucleotide binding]; other site 1166016005699 putative Zn2+ binding site [ion binding]; other site 1166016005700 AsnC family; Region: AsnC_trans_reg; pfam01037 1166016005701 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1166016005702 DNA translocase FtsK; Provisional; Region: PRK10263 1166016005703 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1166016005704 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1166016005705 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1166016005706 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1166016005707 recombination factor protein RarA; Reviewed; Region: PRK13342 1166016005708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016005709 Walker A motif; other site 1166016005710 ATP binding site [chemical binding]; other site 1166016005711 Walker B motif; other site 1166016005712 arginine finger; other site 1166016005713 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1166016005714 seryl-tRNA synthetase; Provisional; Region: PRK05431 1166016005715 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1166016005716 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1166016005717 dimer interface [polypeptide binding]; other site 1166016005718 active site 1166016005719 motif 1; other site 1166016005720 motif 2; other site 1166016005721 motif 3; other site 1166016005722 putative MFS family transporter protein; Provisional; Region: PRK03633 1166016005723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016005724 putative substrate translocation pore; other site 1166016005725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016005726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016005727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016005728 dimerization interface [polypeptide binding]; other site 1166016005729 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1166016005730 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1166016005731 Na binding site [ion binding]; other site 1166016005732 Protein of unknown function (DUF917); Region: DUF917; pfam06032 1166016005733 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1166016005734 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1166016005735 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1166016005736 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1166016005737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016005738 FeS/SAM binding site; other site 1166016005739 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1166016005740 Pyruvate formate lyase 1; Region: PFL1; cd01678 1166016005741 coenzyme A binding site [chemical binding]; other site 1166016005742 active site 1166016005743 catalytic residues [active] 1166016005744 glycine loop; other site 1166016005745 formate transporter; Provisional; Region: PRK10805 1166016005746 uncharacterized domain; Region: TIGR00702 1166016005747 YcaO-like family; Region: YcaO; pfam02624 1166016005748 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1166016005749 homodimer interface [polypeptide binding]; other site 1166016005750 substrate-cofactor binding pocket; other site 1166016005751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016005752 catalytic residue [active] 1166016005753 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1166016005754 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1166016005755 hinge; other site 1166016005756 active site 1166016005757 cytidylate kinase; Provisional; Region: cmk; PRK00023 1166016005758 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1166016005759 CMP-binding site; other site 1166016005760 The sites determining sugar specificity; other site 1166016005761 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1166016005762 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1166016005763 RNA binding site [nucleotide binding]; other site 1166016005764 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1166016005765 RNA binding site [nucleotide binding]; other site 1166016005766 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1166016005767 RNA binding site [nucleotide binding]; other site 1166016005768 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1166016005769 RNA binding site [nucleotide binding]; other site 1166016005770 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1166016005771 RNA binding site [nucleotide binding]; other site 1166016005772 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1166016005773 RNA binding site [nucleotide binding]; other site 1166016005774 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166016005775 IHF dimer interface [polypeptide binding]; other site 1166016005776 IHF - DNA interface [nucleotide binding]; other site 1166016005777 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1166016005778 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1166016005779 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1166016005780 metal binding site [ion binding]; metal-binding site 1166016005781 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1166016005782 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1166016005783 substrate binding site [chemical binding]; other site 1166016005784 glutamase interaction surface [polypeptide binding]; other site 1166016005785 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1166016005786 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1166016005787 catalytic residues [active] 1166016005788 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1166016005789 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1166016005790 putative active site [active] 1166016005791 oxyanion strand; other site 1166016005792 catalytic triad [active] 1166016005793 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1166016005794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016005795 active site 1166016005796 motif I; other site 1166016005797 motif II; other site 1166016005798 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1166016005799 putative active site pocket [active] 1166016005800 4-fold oligomerization interface [polypeptide binding]; other site 1166016005801 metal binding residues [ion binding]; metal-binding site 1166016005802 3-fold/trimer interface [polypeptide binding]; other site 1166016005803 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1166016005804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016005805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016005806 homodimer interface [polypeptide binding]; other site 1166016005807 catalytic residue [active] 1166016005808 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1166016005809 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1166016005810 NAD binding site [chemical binding]; other site 1166016005811 dimerization interface [polypeptide binding]; other site 1166016005812 product binding site; other site 1166016005813 substrate binding site [chemical binding]; other site 1166016005814 zinc binding site [ion binding]; other site 1166016005815 catalytic residues [active] 1166016005816 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1166016005817 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1166016005818 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1166016005819 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166016005820 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1166016005821 putative NAD(P) binding site [chemical binding]; other site 1166016005822 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016005823 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016005824 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016005825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016005826 dimerization interface [polypeptide binding]; other site 1166016005827 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016005828 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016005829 dimer interface [polypeptide binding]; other site 1166016005830 putative CheW interface [polypeptide binding]; other site 1166016005831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016005832 dimerization interface [polypeptide binding]; other site 1166016005833 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016005834 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016005835 dimer interface [polypeptide binding]; other site 1166016005836 putative CheW interface [polypeptide binding]; other site 1166016005837 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1166016005838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016005839 active site 1166016005840 phosphorylation site [posttranslational modification] 1166016005841 intermolecular recognition site; other site 1166016005842 dimerization interface [polypeptide binding]; other site 1166016005843 Transcriptional regulator; Region: CitT; pfam12431 1166016005844 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1166016005845 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1166016005846 PAS domain; Region: PAS; smart00091 1166016005847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016005848 ATP binding site [chemical binding]; other site 1166016005849 Mg2+ binding site [ion binding]; other site 1166016005850 G-X-G motif; other site 1166016005851 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1166016005852 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1166016005853 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1166016005854 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1166016005855 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1166016005856 putative active site [active] 1166016005857 (T/H)XGH motif; other site 1166016005858 citrate lyase subunit gamma; Provisional; Region: PRK13253 1166016005859 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1166016005860 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1166016005861 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 1166016005862 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1166016005863 Flagellar regulator YcgR; Region: YcgR; pfam07317 1166016005864 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1166016005865 PilZ domain; Region: PilZ; pfam07238 1166016005866 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1166016005867 exonuclease I; Provisional; Region: sbcB; PRK11779 1166016005868 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1166016005869 active site 1166016005870 catalytic site [active] 1166016005871 substrate binding site [chemical binding]; other site 1166016005872 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1166016005873 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1166016005874 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1166016005875 putative ligand binding residues [chemical binding]; other site 1166016005876 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016005877 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016005878 ABC-ATPase subunit interface; other site 1166016005879 dimer interface [polypeptide binding]; other site 1166016005880 putative PBP binding regions; other site 1166016005881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016005882 ABC-ATPase subunit interface; other site 1166016005883 dimer interface [polypeptide binding]; other site 1166016005884 putative PBP binding regions; other site 1166016005885 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1166016005886 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016005887 Walker A/P-loop; other site 1166016005888 ATP binding site [chemical binding]; other site 1166016005889 Q-loop/lid; other site 1166016005890 ABC transporter signature motif; other site 1166016005891 Walker B; other site 1166016005892 D-loop; other site 1166016005893 H-loop/switch region; other site 1166016005894 hypothetical protein; Provisional; Region: PRK05423 1166016005895 ComEC family competence protein; Provisional; Region: PRK11539 1166016005896 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1166016005897 Competence protein; Region: Competence; pfam03772 1166016005898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1166016005899 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1166016005900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016005901 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1166016005902 Walker A/P-loop; other site 1166016005903 ATP binding site [chemical binding]; other site 1166016005904 Q-loop/lid; other site 1166016005905 ABC transporter signature motif; other site 1166016005906 Walker B; other site 1166016005907 D-loop; other site 1166016005908 H-loop/switch region; other site 1166016005909 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1166016005910 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1166016005911 Trm112p-like protein; Region: Trm112p; cl01066 1166016005912 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1166016005913 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1166016005914 Ligand binding site; other site 1166016005915 oligomer interface; other site 1166016005916 Right handed beta helix region; Region: Beta_helix; pfam13229 1166016005917 hypothetical protein; Provisional; Region: PRK10593 1166016005918 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1166016005919 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1166016005920 putative active site [active] 1166016005921 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166016005922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016005923 S-adenosylmethionine binding site [chemical binding]; other site 1166016005924 condesin subunit F; Provisional; Region: PRK05260 1166016005925 condesin subunit E; Provisional; Region: PRK05256 1166016005926 cell division protein MukB; Provisional; Region: mukB; PRK04863 1166016005927 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1166016005928 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1166016005929 murein L,D-transpeptidase; Provisional; Region: PRK10594 1166016005930 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1166016005931 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166016005932 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 1166016005933 active site 1166016005934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1166016005935 Peptidase M15; Region: Peptidase_M15_3; cl01194 1166016005936 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1166016005937 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1166016005938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016005939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016005940 homodimer interface [polypeptide binding]; other site 1166016005941 catalytic residue [active] 1166016005942 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1166016005943 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1166016005944 trimer interface [polypeptide binding]; other site 1166016005945 eyelet of channel; other site 1166016005946 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1166016005947 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1166016005948 putative dimer interface [polypeptide binding]; other site 1166016005949 putative anticodon binding site; other site 1166016005950 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1166016005951 homodimer interface [polypeptide binding]; other site 1166016005952 motif 1; other site 1166016005953 motif 2; other site 1166016005954 active site 1166016005955 motif 3; other site 1166016005956 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1166016005957 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1166016005958 active site 1166016005959 aminopeptidase N; Provisional; Region: pepN; PRK14015 1166016005960 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1166016005961 active site 1166016005962 Zn binding site [ion binding]; other site 1166016005963 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1166016005964 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1166016005965 quinone interaction residues [chemical binding]; other site 1166016005966 active site 1166016005967 catalytic residues [active] 1166016005968 FMN binding site [chemical binding]; other site 1166016005969 substrate binding site [chemical binding]; other site 1166016005970 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1166016005971 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1166016005972 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1166016005973 MOSC domain; Region: MOSC; pfam03473 1166016005974 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166016005975 catalytic loop [active] 1166016005976 iron binding site [ion binding]; other site 1166016005977 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1166016005978 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1166016005979 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1166016005980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016005981 S-adenosylmethionine binding site [chemical binding]; other site 1166016005982 ABC transporter ATPase component; Reviewed; Region: PRK11147 1166016005983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016005984 Walker A/P-loop; other site 1166016005985 ATP binding site [chemical binding]; other site 1166016005986 Q-loop/lid; other site 1166016005987 ABC transporter signature motif; other site 1166016005988 Walker B; other site 1166016005989 D-loop; other site 1166016005990 H-loop/switch region; other site 1166016005991 ABC transporter; Region: ABC_tran_2; pfam12848 1166016005992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016005993 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1166016005994 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166016005995 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166016005996 paraquat-inducible protein B; Provisional; Region: PRK10807 1166016005997 mce related protein; Region: MCE; pfam02470 1166016005998 mce related protein; Region: MCE; pfam02470 1166016005999 mce related protein; Region: MCE; pfam02470 1166016006000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1166016006001 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1166016006002 ribosome modulation factor; Provisional; Region: PRK14563 1166016006003 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1166016006004 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016006005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016006006 dimer interface [polypeptide binding]; other site 1166016006007 putative CheW interface [polypeptide binding]; other site 1166016006008 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166016006009 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166016006010 putative hydrolase; Validated; Region: PRK09248 1166016006011 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1166016006012 active site 1166016006013 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1166016006014 lipoprotein; Provisional; Region: PRK10598 1166016006015 glutaredoxin 2; Provisional; Region: PRK10387 1166016006016 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1166016006017 C-terminal domain interface [polypeptide binding]; other site 1166016006018 GSH binding site (G-site) [chemical binding]; other site 1166016006019 catalytic residues [active] 1166016006020 putative dimer interface [polypeptide binding]; other site 1166016006021 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1166016006022 N-terminal domain interface [polypeptide binding]; other site 1166016006023 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1166016006024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006025 putative substrate translocation pore; other site 1166016006026 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1166016006027 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1166016006028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1166016006029 hypothetical protein; Provisional; Region: PRK11239 1166016006030 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016006031 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016006032 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1166016006033 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1166016006034 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1166016006035 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1166016006036 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1166016006037 active site 1166016006038 HIGH motif; other site 1166016006039 KMSK motif region; other site 1166016006040 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1166016006041 tRNA binding surface [nucleotide binding]; other site 1166016006042 anticodon binding site; other site 1166016006043 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1166016006044 putative metal binding site [ion binding]; other site 1166016006045 copper homeostasis protein CutC; Provisional; Region: PRK11572 1166016006046 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1166016006047 putative active site [active] 1166016006048 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1166016006049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016006050 S-adenosylmethionine binding site [chemical binding]; other site 1166016006051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016006052 S-adenosylmethionine binding site [chemical binding]; other site 1166016006053 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1166016006054 hypothetical protein; Provisional; Region: PRK10302 1166016006055 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1166016006056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016006057 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1166016006058 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1166016006059 dimer interface [polypeptide binding]; other site 1166016006060 anticodon binding site; other site 1166016006061 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1166016006062 homodimer interface [polypeptide binding]; other site 1166016006063 motif 1; other site 1166016006064 active site 1166016006065 motif 2; other site 1166016006066 GAD domain; Region: GAD; pfam02938 1166016006067 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1166016006068 active site 1166016006069 motif 3; other site 1166016006070 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1166016006071 nudix motif; other site 1166016006072 hypothetical protein; Validated; Region: PRK00110 1166016006073 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1166016006074 active site 1166016006075 putative DNA-binding cleft [nucleotide binding]; other site 1166016006076 dimer interface [polypeptide binding]; other site 1166016006077 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1166016006078 RuvA N terminal domain; Region: RuvA_N; pfam01330 1166016006079 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1166016006080 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1166016006081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016006082 Walker A motif; other site 1166016006083 ATP binding site [chemical binding]; other site 1166016006084 Walker B motif; other site 1166016006085 arginine finger; other site 1166016006086 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1166016006087 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016006088 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1166016006089 methionine cluster; other site 1166016006090 active site 1166016006091 phosphorylation site [posttranslational modification] 1166016006092 metal binding site [ion binding]; metal-binding site 1166016006093 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166016006094 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166016006095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016006096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016006097 DNA binding site [nucleotide binding] 1166016006098 domain linker motif; other site 1166016006099 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1166016006100 ligand binding site [chemical binding]; other site 1166016006101 dimerization interface [polypeptide binding]; other site 1166016006102 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166016006103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016006104 ABC-ATPase subunit interface; other site 1166016006105 dimer interface [polypeptide binding]; other site 1166016006106 putative PBP binding regions; other site 1166016006107 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1166016006108 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1166016006109 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1166016006110 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1166016006111 metal binding site [ion binding]; metal-binding site 1166016006112 putative peptidase; Provisional; Region: PRK11649 1166016006113 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1166016006114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166016006115 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166016006116 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1166016006117 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166016006118 putative acyl-acceptor binding pocket; other site 1166016006119 pyruvate kinase; Provisional; Region: PRK05826 1166016006120 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1166016006121 domain interfaces; other site 1166016006122 active site 1166016006123 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1166016006124 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166016006125 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166016006126 putative active site [active] 1166016006127 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1166016006128 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1166016006129 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1166016006130 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1166016006131 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1166016006132 active site 1166016006133 intersubunit interface [polypeptide binding]; other site 1166016006134 catalytic residue [active] 1166016006135 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1166016006136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016006137 ATP-grasp domain; Region: ATP-grasp; pfam02222 1166016006138 protease 2; Provisional; Region: PRK10115 1166016006139 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1166016006140 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016006141 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1166016006142 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1166016006143 Ferritin-like domain; Region: Ferritin; pfam00210 1166016006144 ferroxidase diiron center [ion binding]; other site 1166016006145 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1166016006146 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016006147 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1166016006148 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166016006149 DNA-binding site [nucleotide binding]; DNA binding site 1166016006150 RNA-binding motif; other site 1166016006151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166016006152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016006153 Coenzyme A binding pocket [chemical binding]; other site 1166016006154 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1166016006155 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1166016006156 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1166016006157 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1166016006158 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1166016006159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016006160 S-adenosylmethionine binding site [chemical binding]; other site 1166016006161 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1166016006162 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1166016006163 mce related protein; Region: MCE; pfam02470 1166016006164 mce related protein; Region: MCE; pfam02470 1166016006165 mce related protein; Region: MCE; pfam02470 1166016006166 mce related protein; Region: MCE; pfam02470 1166016006167 mce related protein; Region: MCE; pfam02470 1166016006168 mce related protein; Region: MCE; pfam02470 1166016006169 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1166016006170 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166016006171 Paraquat-inducible protein A; Region: PqiA; pfam04403 1166016006172 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1166016006173 GAF domain; Region: GAF_2; pfam13185 1166016006174 ProP expression regulator; Provisional; Region: PRK04950 1166016006175 ProQ/FINO family; Region: ProQ; pfam04352 1166016006176 carboxy-terminal protease; Provisional; Region: PRK11186 1166016006177 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1166016006178 protein binding site [polypeptide binding]; other site 1166016006179 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1166016006180 Catalytic dyad [active] 1166016006181 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1166016006182 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016006183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016006184 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1166016006185 substrate binding site [chemical binding]; other site 1166016006186 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1166016006187 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1166016006188 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016006189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016006190 dimer interface [polypeptide binding]; other site 1166016006191 conserved gate region; other site 1166016006192 putative PBP binding loops; other site 1166016006193 ABC-ATPase subunit interface; other site 1166016006194 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016006195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016006196 dimer interface [polypeptide binding]; other site 1166016006197 conserved gate region; other site 1166016006198 putative PBP binding loops; other site 1166016006199 ABC-ATPase subunit interface; other site 1166016006200 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1166016006201 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1166016006202 Walker A/P-loop; other site 1166016006203 ATP binding site [chemical binding]; other site 1166016006204 Q-loop/lid; other site 1166016006205 ABC transporter signature motif; other site 1166016006206 Walker B; other site 1166016006207 D-loop; other site 1166016006208 H-loop/switch region; other site 1166016006209 TOBE domain; Region: TOBE_2; pfam08402 1166016006210 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1166016006211 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1166016006212 metal binding site [ion binding]; metal-binding site 1166016006213 dimer interface [polypeptide binding]; other site 1166016006214 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1166016006215 Cupin domain; Region: Cupin_2; cl17218 1166016006216 sensor protein PhoQ; Provisional; Region: PRK10815 1166016006217 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1166016006218 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1166016006219 dimer interface [polypeptide binding]; other site 1166016006220 phosphorylation site [posttranslational modification] 1166016006221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016006222 ATP binding site [chemical binding]; other site 1166016006223 Mg2+ binding site [ion binding]; other site 1166016006224 G-X-G motif; other site 1166016006225 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1166016006226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016006227 active site 1166016006228 phosphorylation site [posttranslational modification] 1166016006229 intermolecular recognition site; other site 1166016006230 dimerization interface [polypeptide binding]; other site 1166016006231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016006232 DNA binding site [nucleotide binding] 1166016006233 adenylosuccinate lyase; Provisional; Region: PRK09285 1166016006234 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1166016006235 tetramer interface [polypeptide binding]; other site 1166016006236 active site 1166016006237 putative lysogenization regulator; Reviewed; Region: PRK00218 1166016006238 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1166016006239 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1166016006240 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1166016006241 nudix motif; other site 1166016006242 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1166016006243 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1166016006244 active site 1166016006245 isocitrate dehydrogenase; Validated; Region: PRK07362 1166016006246 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1166016006247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1166016006248 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1166016006249 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1166016006250 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1166016006251 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1166016006252 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016006253 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1166016006254 Mor transcription activator family; Region: Mor; pfam08765 1166016006255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016006256 non-specific DNA binding site [nucleotide binding]; other site 1166016006257 salt bridge; other site 1166016006258 Predicted transcriptional regulator [Transcription]; Region: COG2932 1166016006259 sequence-specific DNA binding site [nucleotide binding]; other site 1166016006260 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1166016006261 Catalytic site [active] 1166016006262 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166016006263 GAF domain; Region: GAF; pfam01590 1166016006264 PAS domain S-box; Region: sensory_box; TIGR00229 1166016006265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016006266 putative active site [active] 1166016006267 heme pocket [chemical binding]; other site 1166016006268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016006269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016006270 metal binding site [ion binding]; metal-binding site 1166016006271 active site 1166016006272 I-site; other site 1166016006273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016006274 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1166016006275 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1166016006276 GAF domain; Region: GAF_3; pfam13492 1166016006277 Histidine kinase; Region: His_kinase; pfam06580 1166016006278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016006279 ATP binding site [chemical binding]; other site 1166016006280 Mg2+ binding site [ion binding]; other site 1166016006281 G-X-G motif; other site 1166016006282 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1166016006283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016006284 active site 1166016006285 phosphorylation site [posttranslational modification] 1166016006286 intermolecular recognition site; other site 1166016006287 dimerization interface [polypeptide binding]; other site 1166016006288 LytTr DNA-binding domain; Region: LytTR; pfam04397 1166016006289 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1166016006290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006291 putative substrate translocation pore; other site 1166016006292 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166016006293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166016006294 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1166016006295 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 1166016006296 putative active site [active] 1166016006297 catalytic site [active] 1166016006298 putative metal binding site [ion binding]; other site 1166016006299 oligomer interface [polypeptide binding]; other site 1166016006300 heat shock protein HtpX; Provisional; Region: PRK05457 1166016006301 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1166016006302 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166016006303 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1166016006304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016006305 dimerization interface [polypeptide binding]; other site 1166016006306 putative Zn2+ binding site [ion binding]; other site 1166016006307 putative DNA binding site [nucleotide binding]; other site 1166016006308 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166016006309 YebO-like protein; Region: YebO; pfam13974 1166016006310 aromatic amino acid transporter; Provisional; Region: PRK10238 1166016006311 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1166016006312 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1166016006313 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1166016006314 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1166016006315 active site 1166016006316 dimer interface [polypeptide binding]; other site 1166016006317 motif 1; other site 1166016006318 motif 2; other site 1166016006319 motif 3; other site 1166016006320 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1166016006321 anticodon binding site; other site 1166016006322 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1166016006323 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1166016006324 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1166016006325 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1166016006326 23S rRNA binding site [nucleotide binding]; other site 1166016006327 L21 binding site [polypeptide binding]; other site 1166016006328 L13 binding site [polypeptide binding]; other site 1166016006329 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1166016006330 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1166016006331 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1166016006332 dimer interface [polypeptide binding]; other site 1166016006333 motif 1; other site 1166016006334 active site 1166016006335 motif 2; other site 1166016006336 motif 3; other site 1166016006337 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1166016006338 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1166016006339 putative tRNA-binding site [nucleotide binding]; other site 1166016006340 B3/4 domain; Region: B3_4; pfam03483 1166016006341 tRNA synthetase B5 domain; Region: B5; smart00874 1166016006342 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1166016006343 dimer interface [polypeptide binding]; other site 1166016006344 motif 1; other site 1166016006345 motif 3; other site 1166016006346 motif 2; other site 1166016006347 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1166016006348 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166016006349 IHF dimer interface [polypeptide binding]; other site 1166016006350 IHF - DNA interface [nucleotide binding]; other site 1166016006351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166016006352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016006353 Coenzyme A binding pocket [chemical binding]; other site 1166016006354 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1166016006355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1166016006356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016006357 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1166016006358 Walker A/P-loop; other site 1166016006359 ATP binding site [chemical binding]; other site 1166016006360 Q-loop/lid; other site 1166016006361 ABC transporter signature motif; other site 1166016006362 Walker B; other site 1166016006363 D-loop; other site 1166016006364 H-loop/switch region; other site 1166016006365 aromatic amino acid exporter; Provisional; Region: PRK11689 1166016006366 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1166016006367 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1166016006368 homodimer interface [polypeptide binding]; other site 1166016006369 NAD binding pocket [chemical binding]; other site 1166016006370 ATP binding pocket [chemical binding]; other site 1166016006371 Mg binding site [ion binding]; other site 1166016006372 active-site loop [active] 1166016006373 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1166016006374 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1166016006375 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166016006376 inner membrane protein; Provisional; Region: PRK11648 1166016006377 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1166016006378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016006379 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1166016006380 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166016006381 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166016006382 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1166016006383 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166016006384 Walker A/P-loop; other site 1166016006385 ATP binding site [chemical binding]; other site 1166016006386 Q-loop/lid; other site 1166016006387 ABC transporter signature motif; other site 1166016006388 Walker B; other site 1166016006389 D-loop; other site 1166016006390 H-loop/switch region; other site 1166016006391 TOBE domain; Region: TOBE; pfam03459 1166016006392 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166016006393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016006394 dimer interface [polypeptide binding]; other site 1166016006395 conserved gate region; other site 1166016006396 putative PBP binding loops; other site 1166016006397 ABC-ATPase subunit interface; other site 1166016006398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016006399 dimer interface [polypeptide binding]; other site 1166016006400 conserved gate region; other site 1166016006401 putative PBP binding loops; other site 1166016006402 ABC-ATPase subunit interface; other site 1166016006403 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 1166016006404 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1166016006405 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1166016006406 NADP binding site [chemical binding]; other site 1166016006407 homodimer interface [polypeptide binding]; other site 1166016006408 active site 1166016006409 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1166016006410 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1166016006411 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1166016006412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016006413 motif II; other site 1166016006414 YniB-like protein; Region: YniB; pfam14002 1166016006415 Phosphotransferase enzyme family; Region: APH; pfam01636 1166016006416 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1166016006417 active site 1166016006418 ATP binding site [chemical binding]; other site 1166016006419 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1166016006420 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166016006421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016006422 ABC-ATPase subunit interface; other site 1166016006423 dimer interface [polypeptide binding]; other site 1166016006424 putative PBP binding regions; other site 1166016006425 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166016006426 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016006427 ABC-ATPase subunit interface; other site 1166016006428 dimer interface [polypeptide binding]; other site 1166016006429 putative PBP binding regions; other site 1166016006430 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1166016006431 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1166016006432 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1166016006433 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1166016006434 metal binding site [ion binding]; metal-binding site 1166016006435 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166016006436 DNA-binding site [nucleotide binding]; DNA binding site 1166016006437 RNA-binding motif; other site 1166016006438 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1166016006439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016006440 S-adenosylmethionine binding site [chemical binding]; other site 1166016006441 hypothetical protein; Provisional; Region: PRK11469 1166016006442 Domain of unknown function DUF; Region: DUF204; pfam02659 1166016006443 Domain of unknown function DUF; Region: DUF204; pfam02659 1166016006444 hypothetical protein; Provisional; Region: PRK02913 1166016006445 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1166016006446 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1166016006447 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1166016006448 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1166016006449 active pocket/dimerization site; other site 1166016006450 active site 1166016006451 phosphorylation site [posttranslational modification] 1166016006452 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1166016006453 active site 1166016006454 phosphorylation site [posttranslational modification] 1166016006455 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1166016006456 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1166016006457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166016006458 Transporter associated domain; Region: CorC_HlyC; smart01091 1166016006459 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1166016006460 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1166016006461 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1166016006462 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1166016006463 putative active site [active] 1166016006464 putative CoA binding site [chemical binding]; other site 1166016006465 nudix motif; other site 1166016006466 metal binding site [ion binding]; metal-binding site 1166016006467 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1166016006468 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1166016006469 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1166016006470 hypothetical protein; Provisional; Region: PRK05114 1166016006471 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1166016006472 homotrimer interaction site [polypeptide binding]; other site 1166016006473 putative active site [active] 1166016006474 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1166016006475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1166016006476 DEAD_2; Region: DEAD_2; pfam06733 1166016006477 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1166016006478 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1166016006479 Glycoprotease family; Region: Peptidase_M22; pfam00814 1166016006480 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1166016006481 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1166016006482 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1166016006483 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1166016006484 acyl-activating enzyme (AAE) consensus motif; other site 1166016006485 putative AMP binding site [chemical binding]; other site 1166016006486 putative active site [active] 1166016006487 putative CoA binding site [chemical binding]; other site 1166016006488 ribonuclease D; Provisional; Region: PRK10829 1166016006489 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1166016006490 catalytic site [active] 1166016006491 putative active site [active] 1166016006492 putative substrate binding site [chemical binding]; other site 1166016006493 HRDC domain; Region: HRDC; pfam00570 1166016006494 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1166016006495 cell division inhibitor MinD; Provisional; Region: PRK10818 1166016006496 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1166016006497 Switch I; other site 1166016006498 Switch II; other site 1166016006499 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1166016006500 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1166016006501 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1166016006502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1166016006503 hypothetical protein; Provisional; Region: PRK10691 1166016006504 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1166016006505 hypothetical protein; Provisional; Region: PRK05170 1166016006506 Glycogen synthesis protein; Region: GlgS; cl11663 1166016006507 disulfide bond formation protein B; Provisional; Region: PRK01749 1166016006508 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1166016006509 fatty acid metabolism regulator; Provisional; Region: PRK04984 1166016006510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016006511 DNA-binding site [nucleotide binding]; DNA binding site 1166016006512 FadR C-terminal domain; Region: FadR_C; pfam07840 1166016006513 SpoVR family protein; Provisional; Region: PRK11767 1166016006514 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1166016006515 Class I aldolases; Region: Aldolase_Class_I; cl17187 1166016006516 catalytic residue [active] 1166016006517 AAA domain; Region: AAA_17; pfam13207 1166016006518 AAA domain; Region: AAA_18; pfam13238 1166016006519 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016006520 active site 1166016006521 phosphorylation site [posttranslational modification] 1166016006522 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1166016006523 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1166016006524 active site 1166016006525 P-loop; other site 1166016006526 phosphorylation site [posttranslational modification] 1166016006527 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1166016006528 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1166016006529 active site 1166016006530 ADP/pyrophosphate binding site [chemical binding]; other site 1166016006531 dimerization interface [polypeptide binding]; other site 1166016006532 allosteric effector site; other site 1166016006533 fructose-1,6-bisphosphate binding site; other site 1166016006534 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1166016006535 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1166016006536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006537 putative substrate translocation pore; other site 1166016006538 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1166016006539 hypothetical protein; Provisional; Region: PRK05325 1166016006540 PrkA family serine protein kinase; Provisional; Region: PRK15455 1166016006541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016006542 Walker A motif; other site 1166016006543 ATP binding site [chemical binding]; other site 1166016006544 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1166016006545 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1166016006546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016006547 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016006548 active site 1166016006549 catalytic tetrad [active] 1166016006550 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1166016006551 active site 1166016006552 phosphate binding residues; other site 1166016006553 catalytic residues [active] 1166016006554 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1166016006555 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1166016006556 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1166016006557 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1166016006558 SelR domain; Region: SelR; pfam01641 1166016006559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1166016006560 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1166016006561 Isochorismatase family; Region: Isochorismatase; pfam00857 1166016006562 catalytic triad [active] 1166016006563 metal binding site [ion binding]; metal-binding site 1166016006564 conserved cis-peptide bond; other site 1166016006565 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1166016006566 active site 1166016006567 homodimer interface [polypeptide binding]; other site 1166016006568 protease 4; Provisional; Region: PRK10949 1166016006569 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1166016006570 tandem repeat interface [polypeptide binding]; other site 1166016006571 oligomer interface [polypeptide binding]; other site 1166016006572 active site residues [active] 1166016006573 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1166016006574 tandem repeat interface [polypeptide binding]; other site 1166016006575 oligomer interface [polypeptide binding]; other site 1166016006576 active site residues [active] 1166016006577 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1166016006578 putative FMN binding site [chemical binding]; other site 1166016006579 DNA topoisomerase III; Provisional; Region: PRK07726 1166016006580 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1166016006581 active site 1166016006582 putative interdomain interaction site [polypeptide binding]; other site 1166016006583 putative metal-binding site [ion binding]; other site 1166016006584 putative nucleotide binding site [chemical binding]; other site 1166016006585 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1166016006586 domain I; other site 1166016006587 DNA binding groove [nucleotide binding] 1166016006588 phosphate binding site [ion binding]; other site 1166016006589 domain II; other site 1166016006590 domain III; other site 1166016006591 nucleotide binding site [chemical binding]; other site 1166016006592 catalytic site [active] 1166016006593 domain IV; other site 1166016006594 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1166016006595 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1166016006596 putative catalytic site [active] 1166016006597 putative phosphate binding site [ion binding]; other site 1166016006598 active site 1166016006599 metal binding site A [ion binding]; metal-binding site 1166016006600 DNA binding site [nucleotide binding] 1166016006601 putative AP binding site [nucleotide binding]; other site 1166016006602 putative metal binding site B [ion binding]; other site 1166016006603 Predicted membrane protein [Function unknown]; Region: COG2860 1166016006604 UPF0126 domain; Region: UPF0126; pfam03458 1166016006605 UPF0126 domain; Region: UPF0126; pfam03458 1166016006606 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016006607 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1166016006608 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1166016006609 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1166016006610 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1166016006611 putative active site [active] 1166016006612 putative substrate binding site [chemical binding]; other site 1166016006613 putative cosubstrate binding site; other site 1166016006614 catalytic site [active] 1166016006615 hypothetical protein; Provisional; Region: PRK04233 1166016006616 hypothetical protein; Provisional; Region: PRK10279 1166016006617 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1166016006618 active site 1166016006619 nucleophile elbow; other site 1166016006620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016006621 active site 1166016006622 response regulator of RpoS; Provisional; Region: PRK10693 1166016006623 phosphorylation site [posttranslational modification] 1166016006624 intermolecular recognition site; other site 1166016006625 dimerization interface [polypeptide binding]; other site 1166016006626 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1166016006627 active site 1166016006628 tetramer interface; other site 1166016006629 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1166016006630 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1166016006631 thymidine kinase; Provisional; Region: PRK04296 1166016006632 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1166016006633 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1166016006634 putative catalytic cysteine [active] 1166016006635 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1166016006636 putative active site [active] 1166016006637 metal binding site [ion binding]; metal-binding site 1166016006638 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166016006639 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166016006640 peptide binding site [polypeptide binding]; other site 1166016006641 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166016006642 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166016006643 peptide binding site [polypeptide binding]; other site 1166016006644 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1166016006645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016006646 dimer interface [polypeptide binding]; other site 1166016006647 conserved gate region; other site 1166016006648 putative PBP binding loops; other site 1166016006649 ABC-ATPase subunit interface; other site 1166016006650 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1166016006651 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166016006652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016006653 dimer interface [polypeptide binding]; other site 1166016006654 conserved gate region; other site 1166016006655 ABC-ATPase subunit interface; other site 1166016006656 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1166016006657 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016006658 Walker A/P-loop; other site 1166016006659 ATP binding site [chemical binding]; other site 1166016006660 Q-loop/lid; other site 1166016006661 ABC transporter signature motif; other site 1166016006662 Walker B; other site 1166016006663 D-loop; other site 1166016006664 H-loop/switch region; other site 1166016006665 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166016006666 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1166016006667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016006668 Walker A/P-loop; other site 1166016006669 ATP binding site [chemical binding]; other site 1166016006670 Q-loop/lid; other site 1166016006671 ABC transporter signature motif; other site 1166016006672 Walker B; other site 1166016006673 D-loop; other site 1166016006674 H-loop/switch region; other site 1166016006675 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1166016006676 dsDNA-mimic protein; Reviewed; Region: PRK05094 1166016006677 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1166016006678 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1166016006679 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1166016006680 putative active site [active] 1166016006681 catalytic site [active] 1166016006682 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1166016006683 putative active site [active] 1166016006684 catalytic site [active] 1166016006685 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1166016006686 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166016006687 dimer interface [polypeptide binding]; other site 1166016006688 ligand binding site [chemical binding]; other site 1166016006689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016006690 dimerization interface [polypeptide binding]; other site 1166016006691 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016006692 dimer interface [polypeptide binding]; other site 1166016006693 putative CheW interface [polypeptide binding]; other site 1166016006694 YciI-like protein; Reviewed; Region: PRK11370 1166016006695 transport protein TonB; Provisional; Region: PRK10819 1166016006696 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1166016006697 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1166016006698 intracellular septation protein A; Reviewed; Region: PRK00259 1166016006699 hypothetical protein; Provisional; Region: PRK02868 1166016006700 outer membrane protein W; Provisional; Region: PRK10959 1166016006701 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1166016006702 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1166016006703 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1166016006704 substrate binding site [chemical binding]; other site 1166016006705 active site 1166016006706 catalytic residues [active] 1166016006707 heterodimer interface [polypeptide binding]; other site 1166016006708 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1166016006709 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1166016006710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016006711 catalytic residue [active] 1166016006712 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1166016006713 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1166016006714 active site 1166016006715 ribulose/triose binding site [chemical binding]; other site 1166016006716 phosphate binding site [ion binding]; other site 1166016006717 substrate (anthranilate) binding pocket [chemical binding]; other site 1166016006718 product (indole) binding pocket [chemical binding]; other site 1166016006719 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1166016006720 active site 1166016006721 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1166016006722 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1166016006723 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1166016006724 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1166016006725 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1166016006726 glutamine binding [chemical binding]; other site 1166016006727 catalytic triad [active] 1166016006728 anthranilate synthase component I; Provisional; Region: PRK13564 1166016006729 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1166016006730 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1166016006731 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1166016006732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016006733 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1166016006734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166016006735 active site 1166016006736 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1166016006737 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1166016006738 active site 1166016006739 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1166016006740 hypothetical protein; Provisional; Region: PRK11630 1166016006741 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1166016006742 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016006743 RNA binding surface [nucleotide binding]; other site 1166016006744 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1166016006745 probable active site [active] 1166016006746 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1166016006747 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1166016006748 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1166016006749 homodimer interface [polypeptide binding]; other site 1166016006750 Walker A motif; other site 1166016006751 ATP binding site [chemical binding]; other site 1166016006752 hydroxycobalamin binding site [chemical binding]; other site 1166016006753 Walker B motif; other site 1166016006754 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1166016006755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016006756 NAD(P) binding site [chemical binding]; other site 1166016006757 active site 1166016006758 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1166016006759 putative inner membrane peptidase; Provisional; Region: PRK11778 1166016006760 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1166016006761 tandem repeat interface [polypeptide binding]; other site 1166016006762 oligomer interface [polypeptide binding]; other site 1166016006763 active site residues [active] 1166016006764 hypothetical protein; Provisional; Region: PRK11037 1166016006765 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1166016006766 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1166016006767 active site 1166016006768 interdomain interaction site; other site 1166016006769 putative metal-binding site [ion binding]; other site 1166016006770 nucleotide binding site [chemical binding]; other site 1166016006771 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1166016006772 domain I; other site 1166016006773 DNA binding groove [nucleotide binding] 1166016006774 phosphate binding site [ion binding]; other site 1166016006775 domain II; other site 1166016006776 domain III; other site 1166016006777 nucleotide binding site [chemical binding]; other site 1166016006778 catalytic site [active] 1166016006779 domain IV; other site 1166016006780 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016006781 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016006782 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1166016006783 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1166016006784 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1166016006785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016006786 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1166016006787 substrate binding site [chemical binding]; other site 1166016006788 putative dimerization interface [polypeptide binding]; other site 1166016006789 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1166016006790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006791 putative substrate translocation pore; other site 1166016006792 POT family; Region: PTR2; pfam00854 1166016006793 endonuclease III; Provisional; Region: PRK10702 1166016006794 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1166016006795 minor groove reading motif; other site 1166016006796 helix-hairpin-helix signature motif; other site 1166016006797 substrate binding pocket [chemical binding]; other site 1166016006798 active site 1166016006799 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1166016006800 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1166016006801 electron transport complex protein RnfG; Validated; Region: PRK01908 1166016006802 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1166016006803 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1166016006804 SLBB domain; Region: SLBB; pfam10531 1166016006805 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016006806 electron transport complex protein RnfB; Provisional; Region: PRK05113 1166016006807 Putative Fe-S cluster; Region: FeS; pfam04060 1166016006808 4Fe-4S binding domain; Region: Fer4; pfam00037 1166016006809 electron transport complex protein RsxA; Provisional; Region: PRK05151 1166016006810 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1166016006811 ribulokinase; Provisional; Region: PRK04123 1166016006812 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1166016006813 N- and C-terminal domain interface [polypeptide binding]; other site 1166016006814 active site 1166016006815 MgATP binding site [chemical binding]; other site 1166016006816 catalytic site [active] 1166016006817 metal binding site [ion binding]; metal-binding site 1166016006818 carbohydrate binding site [chemical binding]; other site 1166016006819 homodimer interface [polypeptide binding]; other site 1166016006820 L-arabinose isomerase; Provisional; Region: PRK02929 1166016006821 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1166016006822 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1166016006823 trimer interface [polypeptide binding]; other site 1166016006824 putative substrate binding site [chemical binding]; other site 1166016006825 putative metal binding site [ion binding]; other site 1166016006826 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1166016006827 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1166016006828 ligand binding site [chemical binding]; other site 1166016006829 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1166016006830 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016006831 Walker A/P-loop; other site 1166016006832 ATP binding site [chemical binding]; other site 1166016006833 Q-loop/lid; other site 1166016006834 ABC transporter signature motif; other site 1166016006835 Walker B; other site 1166016006836 D-loop; other site 1166016006837 H-loop/switch region; other site 1166016006838 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016006839 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016006840 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016006841 TM-ABC transporter signature motif; other site 1166016006842 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1166016006843 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016006844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016006845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016006846 putative oxidoreductase; Provisional; Region: PRK11579 1166016006847 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016006848 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016006849 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1166016006850 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1166016006851 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1166016006852 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1166016006853 SnoaL-like domain; Region: SnoaL_3; pfam13474 1166016006854 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1166016006855 adenosine deaminase; Provisional; Region: PRK09358 1166016006856 active site 1166016006857 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1166016006858 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1166016006859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1166016006860 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1166016006861 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1166016006862 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1166016006863 Class II fumarases; Region: Fumarase_classII; cd01362 1166016006864 active site 1166016006865 tetramer interface [polypeptide binding]; other site 1166016006866 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1166016006867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006868 putative substrate translocation pore; other site 1166016006869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016006870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016006871 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1166016006872 dimerization interface [polypeptide binding]; other site 1166016006873 substrate binding pocket [chemical binding]; other site 1166016006874 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1166016006875 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1166016006876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166016006877 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1166016006878 AAA domain; Region: AAA_26; pfam13500 1166016006879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006880 putative substrate translocation pore; other site 1166016006881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016006882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006883 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1166016006884 hypothetical protein; Provisional; Region: PRK13659 1166016006885 malonic semialdehyde reductase; Provisional; Region: PRK10538 1166016006886 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1166016006887 putative NAD(P) binding site [chemical binding]; other site 1166016006888 homodimer interface [polypeptide binding]; other site 1166016006889 homotetramer interface [polypeptide binding]; other site 1166016006890 active site 1166016006891 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1166016006892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016006893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016006894 homodimer interface [polypeptide binding]; other site 1166016006895 catalytic residue [active] 1166016006896 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1166016006897 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1166016006898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016006899 catalytic residue [active] 1166016006900 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1166016006901 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016006902 inhibitor-cofactor binding pocket; inhibition site 1166016006903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016006904 catalytic residue [active] 1166016006905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1166016006906 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1166016006907 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1166016006908 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1166016006909 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1166016006910 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166016006911 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1166016006912 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1166016006913 active site 1166016006914 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1166016006915 active site 1166016006916 catalytic residues [active] 1166016006917 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1166016006918 phage assembly protein; Region: IV; PHA00019 1166016006919 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016006920 Zonular occludens toxin (Zot); Region: Zot; cl17485 1166016006921 Replication initiation factor; Region: Rep_trans; pfam02486 1166016006922 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1166016006923 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1166016006924 HTH-like domain; Region: HTH_21; pfam13276 1166016006925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016006926 Integrase core domain; Region: rve; pfam00665 1166016006927 Integrase core domain; Region: rve_3; pfam13683 1166016006928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016006929 Transposase; Region: HTH_Tnp_1; pfam01527 1166016006930 phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629 1166016006931 Phage X family; Region: Phage_X; cl11585 1166016006932 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 1166016006933 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1166016006934 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1166016006935 phage assembly protein; Region: IV; PHA00019 1166016006936 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016006937 Zonular occludens toxin (Zot); Region: Zot; cl17485 1166016006938 PPP4R2; Region: PPP4R2; pfam09184 1166016006939 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 1166016006940 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 1166016006941 hypothetical protein; Provisional; Region: PRK10515 1166016006942 Cache domain; Region: Cache_1; pfam02743 1166016006943 HAMP domain; Region: HAMP; pfam00672 1166016006944 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016006945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016006946 dimer interface [polypeptide binding]; other site 1166016006947 putative CheW interface [polypeptide binding]; other site 1166016006948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016006949 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166016006950 Coenzyme A binding pocket [chemical binding]; other site 1166016006951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016006952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016006953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1166016006954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016006955 Cytochrome b562; Region: Cytochrom_B562; pfam07361 1166016006956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016006957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016006958 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166016006959 putative effector binding pocket; other site 1166016006960 dimerization interface [polypeptide binding]; other site 1166016006961 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1166016006962 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1166016006963 putative NAD(P) binding site [chemical binding]; other site 1166016006964 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1166016006965 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1166016006966 Virulence factor SrfB; Region: SrfB; pfam07520 1166016006967 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1166016006968 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1166016006969 putative catalytic site [active] 1166016006970 putative metal binding site [ion binding]; other site 1166016006971 putative phosphate binding site [ion binding]; other site 1166016006972 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1166016006973 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166016006974 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016006975 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1166016006976 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1166016006977 active site 1166016006978 phosphorylation site [posttranslational modification] 1166016006979 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1166016006980 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1166016006981 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1166016006982 active pocket/dimerization site; other site 1166016006983 active site 1166016006984 phosphorylation site [posttranslational modification] 1166016006985 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1166016006986 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1166016006987 active site 1166016006988 dimer interface [polypeptide binding]; other site 1166016006989 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1166016006990 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1166016006991 dimer interface [polypeptide binding]; other site 1166016006992 active site 1166016006993 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1166016006994 putative active site [active] 1166016006995 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1166016006996 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1166016006997 intersubunit interface [polypeptide binding]; other site 1166016006998 active site 1166016006999 zinc binding site [ion binding]; other site 1166016007000 Na+ binding site [ion binding]; other site 1166016007001 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1166016007002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166016007003 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016007004 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016007005 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016007006 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1166016007007 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1166016007008 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166016007009 DNA binding site [nucleotide binding] 1166016007010 active site 1166016007011 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1166016007012 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1166016007013 ligand binding site [chemical binding]; other site 1166016007014 flexible hinge region; other site 1166016007015 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1166016007016 putative switch regulator; other site 1166016007017 non-specific DNA interactions [nucleotide binding]; other site 1166016007018 DNA binding site [nucleotide binding] 1166016007019 sequence specific DNA binding site [nucleotide binding]; other site 1166016007020 putative cAMP binding site [chemical binding]; other site 1166016007021 universal stress protein UspE; Provisional; Region: PRK11175 1166016007022 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166016007023 Ligand Binding Site [chemical binding]; other site 1166016007024 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166016007025 Ligand Binding Site [chemical binding]; other site 1166016007026 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1166016007027 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1166016007028 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1166016007029 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1166016007030 ligand binding site [chemical binding]; other site 1166016007031 homodimer interface [polypeptide binding]; other site 1166016007032 NAD(P) binding site [chemical binding]; other site 1166016007033 trimer interface B [polypeptide binding]; other site 1166016007034 trimer interface A [polypeptide binding]; other site 1166016007035 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1166016007036 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166016007037 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166016007038 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1166016007039 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1166016007040 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166016007041 hypothetical protein; Provisional; Region: PRK10941 1166016007042 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1166016007043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1166016007044 binding surface 1166016007045 TPR motif; other site 1166016007046 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1166016007047 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1166016007048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016007049 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1166016007050 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1166016007051 RF-1 domain; Region: RF-1; pfam00472 1166016007052 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1166016007053 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1166016007054 tRNA; other site 1166016007055 putative tRNA binding site [nucleotide binding]; other site 1166016007056 putative NADP binding site [chemical binding]; other site 1166016007057 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1166016007058 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1166016007059 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1166016007060 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1166016007061 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1166016007062 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1166016007063 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1166016007064 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1166016007065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016007066 active site 1166016007067 hypothetical protein; Provisional; Region: PRK10692 1166016007068 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1166016007069 putative active site [active] 1166016007070 catalytic residue [active] 1166016007071 GTP-binding protein YchF; Reviewed; Region: PRK09601 1166016007072 YchF GTPase; Region: YchF; cd01900 1166016007073 G1 box; other site 1166016007074 GTP/Mg2+ binding site [chemical binding]; other site 1166016007075 Switch I region; other site 1166016007076 G2 box; other site 1166016007077 Switch II region; other site 1166016007078 G3 box; other site 1166016007079 G4 box; other site 1166016007080 G5 box; other site 1166016007081 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1166016007082 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1166016007083 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1166016007084 RHS Repeat; Region: RHS_repeat; pfam05593 1166016007085 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016007086 RHS Repeat; Region: RHS_repeat; cl11982 1166016007087 RHS Repeat; Region: RHS_repeat; pfam05593 1166016007088 RHS Repeat; Region: RHS_repeat; cl11982 1166016007089 RHS Repeat; Region: RHS_repeat; cl11982 1166016007090 RHS Repeat; Region: RHS_repeat; cl11982 1166016007091 RHS protein; Region: RHS; pfam03527 1166016007092 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016007093 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016007094 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1166016007095 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016007096 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016007097 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1166016007098 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1166016007099 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016007100 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016007101 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016007102 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1166016007103 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1166016007104 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1166016007105 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1166016007106 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1166016007107 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1166016007108 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1166016007109 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166016007110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166016007111 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166016007112 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1166016007113 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1166016007114 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166016007115 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166016007116 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1166016007117 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1166016007118 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1166016007119 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016007120 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016007121 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016007122 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1166016007123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1166016007124 active site 1166016007125 ATP binding site [chemical binding]; other site 1166016007126 substrate binding site [chemical binding]; other site 1166016007127 activation loop (A-loop); other site 1166016007128 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1166016007129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016007130 Walker A motif; other site 1166016007131 ATP binding site [chemical binding]; other site 1166016007132 Walker B motif; other site 1166016007133 arginine finger; other site 1166016007134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016007135 Walker A motif; other site 1166016007136 ATP binding site [chemical binding]; other site 1166016007137 Walker B motif; other site 1166016007138 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166016007139 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1166016007140 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1166016007141 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1166016007142 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1166016007143 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1166016007144 ImpE protein; Region: ImpE; pfam07024 1166016007145 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1166016007146 active site 1166016007147 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1166016007148 phosphopeptide binding site; other site 1166016007149 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1166016007150 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1166016007151 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1166016007152 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1166016007153 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1166016007154 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1166016007155 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1166016007156 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1166016007157 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1166016007158 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1166016007159 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1166016007160 hypothetical protein; Provisional; Region: PRK07033 1166016007161 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1166016007162 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166016007163 ligand binding site [chemical binding]; other site 1166016007164 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1166016007165 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1166016007166 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1166016007167 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1166016007168 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1166016007169 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016007170 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1166016007171 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166016007172 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016007173 ABC-ATPase subunit interface; other site 1166016007174 dimer interface [polypeptide binding]; other site 1166016007175 putative PBP binding regions; other site 1166016007176 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166016007177 intersubunit interface [polypeptide binding]; other site 1166016007178 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1166016007179 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166016007180 RNA ligase; Region: RNA_ligase; pfam09414 1166016007181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166016007182 Zn2+ binding site [ion binding]; other site 1166016007183 Mg2+ binding site [ion binding]; other site 1166016007184 AAA domain; Region: AAA_33; pfam13671 1166016007185 AAA domain; Region: AAA_17; pfam13207 1166016007186 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1166016007187 active site 1166016007188 metal binding site [ion binding]; metal-binding site 1166016007189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166016007190 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1166016007191 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1166016007192 active site 1166016007193 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1166016007194 beta-galactosidase; Region: BGL; TIGR03356 1166016007195 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1166016007196 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016007197 active site turn [active] 1166016007198 phosphorylation site [posttranslational modification] 1166016007199 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1166016007200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016007201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016007202 DNA binding site [nucleotide binding] 1166016007203 domain linker motif; other site 1166016007204 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166016007205 dimerization interface (closed form) [polypeptide binding]; other site 1166016007206 ligand binding site [chemical binding]; other site 1166016007207 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1166016007208 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1166016007209 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1166016007210 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1166016007211 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1166016007212 metal binding site [ion binding]; metal-binding site 1166016007213 dimer interface [polypeptide binding]; other site 1166016007214 Flavin Reductases; Region: FlaRed; cl00801 1166016007215 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1166016007216 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1166016007217 active site 1166016007218 non-prolyl cis peptide bond; other site 1166016007219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016007220 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016007221 substrate binding pocket [chemical binding]; other site 1166016007222 membrane-bound complex binding site; other site 1166016007223 hinge residues; other site 1166016007224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016007225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016007226 substrate binding pocket [chemical binding]; other site 1166016007227 membrane-bound complex binding site; other site 1166016007228 hinge residues; other site 1166016007229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016007230 Coenzyme A binding pocket [chemical binding]; other site 1166016007231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016007232 dimer interface [polypeptide binding]; other site 1166016007233 conserved gate region; other site 1166016007234 putative PBP binding loops; other site 1166016007235 ABC-ATPase subunit interface; other site 1166016007236 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016007237 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016007238 Walker A/P-loop; other site 1166016007239 ATP binding site [chemical binding]; other site 1166016007240 Q-loop/lid; other site 1166016007241 ABC transporter signature motif; other site 1166016007242 Walker B; other site 1166016007243 D-loop; other site 1166016007244 H-loop/switch region; other site 1166016007245 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1166016007246 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1166016007247 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1166016007248 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1166016007249 Walker A/P-loop; other site 1166016007250 ATP binding site [chemical binding]; other site 1166016007251 Q-loop/lid; other site 1166016007252 ABC transporter signature motif; other site 1166016007253 Walker B; other site 1166016007254 D-loop; other site 1166016007255 H-loop/switch region; other site 1166016007256 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1166016007257 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1166016007258 Walker A/P-loop; other site 1166016007259 ATP binding site [chemical binding]; other site 1166016007260 Q-loop/lid; other site 1166016007261 ABC transporter signature motif; other site 1166016007262 Walker B; other site 1166016007263 D-loop; other site 1166016007264 H-loop/switch region; other site 1166016007265 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1166016007266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1166016007267 TM-ABC transporter signature motif; other site 1166016007268 HEAT repeats; Region: HEAT_2; pfam13646 1166016007269 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1166016007270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016007271 TM-ABC transporter signature motif; other site 1166016007272 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1166016007273 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1166016007274 putative ligand binding site [chemical binding]; other site 1166016007275 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166016007276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016007277 DNA-binding site [nucleotide binding]; DNA binding site 1166016007278 FCD domain; Region: FCD; pfam07729 1166016007279 urea carboxylase; Region: urea_carbox; TIGR02712 1166016007280 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166016007281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1166016007282 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1166016007283 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1166016007284 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1166016007285 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166016007286 carboxyltransferase (CT) interaction site; other site 1166016007287 biotinylation site [posttranslational modification]; other site 1166016007288 allophanate hydrolase; Provisional; Region: PRK08186 1166016007289 Amidase; Region: Amidase; cl11426 1166016007290 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1166016007291 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1166016007292 inhibitor binding site; inhibition site 1166016007293 active site 1166016007294 putative symporter YagG; Provisional; Region: PRK09669 1166016007295 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1166016007296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016007297 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016007298 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016007299 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016007300 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1166016007301 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1166016007302 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 1166016007303 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166016007304 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1166016007305 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1166016007306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1166016007307 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1166016007308 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1166016007309 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1166016007310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016007311 DNA-binding site [nucleotide binding]; DNA binding site 1166016007312 FCD domain; Region: FCD; pfam07729 1166016007313 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1166016007314 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166016007315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016007316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016007317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016007318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016007319 dimerization interface [polypeptide binding]; other site 1166016007320 hypothetical protein; Provisional; Region: PRK07079 1166016007321 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1166016007322 metal binding site [ion binding]; metal-binding site 1166016007323 putative dimer interface [polypeptide binding]; other site 1166016007324 Bor protein; Region: Lambda_Bor; pfam06291 1166016007325 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1166016007326 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1166016007327 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1166016007328 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1166016007329 active site 1166016007330 octamer interface [polypeptide binding]; other site 1166016007331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016007332 dimer interface [polypeptide binding]; other site 1166016007333 conserved gate region; other site 1166016007334 ABC-ATPase subunit interface; other site 1166016007335 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1166016007336 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166016007337 Walker A/P-loop; other site 1166016007338 ATP binding site [chemical binding]; other site 1166016007339 Q-loop/lid; other site 1166016007340 ABC transporter signature motif; other site 1166016007341 Walker B; other site 1166016007342 D-loop; other site 1166016007343 H-loop/switch region; other site 1166016007344 NIL domain; Region: NIL; pfam09383 1166016007345 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1166016007346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016007347 motif II; other site 1166016007348 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1166016007349 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166016007350 active site 1166016007351 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016007352 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1166016007353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016007354 dimerization interface [polypeptide binding]; other site 1166016007355 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016007356 dimer interface [polypeptide binding]; other site 1166016007357 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016007358 putative CheW interface [polypeptide binding]; other site 1166016007359 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1166016007360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016007361 inhibitor-cofactor binding pocket; inhibition site 1166016007362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016007363 catalytic residue [active] 1166016007364 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1166016007365 active site 1166016007366 ATP binding site [chemical binding]; other site 1166016007367 substrate binding site [chemical binding]; other site 1166016007368 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1166016007369 classical (c) SDRs; Region: SDR_c; cd05233 1166016007370 NAD(P) binding site [chemical binding]; other site 1166016007371 active site 1166016007372 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016007373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016007374 dimer interface [polypeptide binding]; other site 1166016007375 conserved gate region; other site 1166016007376 putative PBP binding loops; other site 1166016007377 ABC-ATPase subunit interface; other site 1166016007378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016007379 dimer interface [polypeptide binding]; other site 1166016007380 conserved gate region; other site 1166016007381 putative PBP binding loops; other site 1166016007382 ABC-ATPase subunit interface; other site 1166016007383 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1166016007384 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166016007385 succinic semialdehyde dehydrogenase; Region: PLN02278 1166016007386 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1166016007387 tetramerization interface [polypeptide binding]; other site 1166016007388 NAD(P) binding site [chemical binding]; other site 1166016007389 catalytic residues [active] 1166016007390 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1166016007391 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016007392 inhibitor-cofactor binding pocket; inhibition site 1166016007393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016007394 catalytic residue [active] 1166016007395 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166016007396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016007397 DNA-binding site [nucleotide binding]; DNA binding site 1166016007398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016007399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016007400 homodimer interface [polypeptide binding]; other site 1166016007401 catalytic residue [active] 1166016007402 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166016007403 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1166016007404 Walker A/P-loop; other site 1166016007405 ATP binding site [chemical binding]; other site 1166016007406 Q-loop/lid; other site 1166016007407 ABC transporter signature motif; other site 1166016007408 Walker B; other site 1166016007409 D-loop; other site 1166016007410 H-loop/switch region; other site 1166016007411 TOBE domain; Region: TOBE_2; pfam08402 1166016007412 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166016007413 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1166016007414 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1166016007415 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166016007416 active site 1166016007417 C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin; Region: Chitin_synth_C; cd04190 1166016007418 DXD motif; other site 1166016007419 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1166016007420 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1166016007421 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166016007422 inhibitor-cofactor binding pocket; inhibition site 1166016007423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016007424 catalytic residue [active] 1166016007425 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166016007426 extended (e) SDRs; Region: SDR_e; cd08946 1166016007427 NAD(P) binding site [chemical binding]; other site 1166016007428 active site 1166016007429 substrate binding site [chemical binding]; other site 1166016007430 hypothetical protein; Provisional; Region: PRK10457 1166016007431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1166016007432 YheO-like PAS domain; Region: PAS_6; pfam08348 1166016007433 HTH domain; Region: HTH_22; pfam13309 1166016007434 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1166016007435 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1166016007436 tetramer interface [polypeptide binding]; other site 1166016007437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016007438 catalytic residue [active] 1166016007439 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1166016007440 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1166016007441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1166016007442 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1166016007443 dimer interface [polypeptide binding]; other site 1166016007444 active site 1166016007445 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166016007446 substrate binding site [chemical binding]; other site 1166016007447 catalytic residue [active] 1166016007448 MarR family; Region: MarR_2; cl17246 1166016007449 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166016007450 EamA-like transporter family; Region: EamA; pfam00892 1166016007451 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166016007452 EamA-like transporter family; Region: EamA; pfam00892 1166016007453 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1166016007454 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1166016007455 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1166016007456 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1166016007457 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1166016007458 [4Fe-4S] binding site [ion binding]; other site 1166016007459 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166016007460 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166016007461 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166016007462 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1166016007463 molybdopterin cofactor binding site; other site 1166016007464 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1166016007465 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1166016007466 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1166016007467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016007468 dimerization interface [polypeptide binding]; other site 1166016007469 Histidine kinase; Region: HisKA_3; pfam07730 1166016007470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016007471 ATP binding site [chemical binding]; other site 1166016007472 Mg2+ binding site [ion binding]; other site 1166016007473 G-X-G motif; other site 1166016007474 transcriptional regulator NarL; Provisional; Region: PRK10651 1166016007475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016007476 active site 1166016007477 phosphorylation site [posttranslational modification] 1166016007478 intermolecular recognition site; other site 1166016007479 dimerization interface [polypeptide binding]; other site 1166016007480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016007481 DNA binding residues [nucleotide binding] 1166016007482 dimerization interface [polypeptide binding]; other site 1166016007483 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166016007484 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1166016007485 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1166016007486 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1166016007487 putative active site pocket [active] 1166016007488 dimerization interface [polypeptide binding]; other site 1166016007489 putative catalytic residue [active] 1166016007490 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1166016007491 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1166016007492 FAD binding pocket [chemical binding]; other site 1166016007493 FAD binding motif [chemical binding]; other site 1166016007494 phosphate binding motif [ion binding]; other site 1166016007495 NAD binding pocket [chemical binding]; other site 1166016007496 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1166016007497 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1166016007498 putative transporter; Provisional; Region: PRK11660 1166016007499 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1166016007500 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1166016007501 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1166016007502 dihydromonapterin reductase; Provisional; Region: PRK06483 1166016007503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016007504 NAD(P) binding site [chemical binding]; other site 1166016007505 active site 1166016007506 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166016007507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016007508 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1166016007509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016007510 active site 1166016007511 phosphorylation site [posttranslational modification] 1166016007512 intermolecular recognition site; other site 1166016007513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016007514 DNA binding site [nucleotide binding] 1166016007515 sensor protein RstB; Provisional; Region: PRK10604 1166016007516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016007517 dimerization interface [polypeptide binding]; other site 1166016007518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016007519 dimer interface [polypeptide binding]; other site 1166016007520 phosphorylation site [posttranslational modification] 1166016007521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016007522 ATP binding site [chemical binding]; other site 1166016007523 Mg2+ binding site [ion binding]; other site 1166016007524 G-X-G motif; other site 1166016007525 acid shock protein precursor; Provisional; Region: PRK03577 1166016007526 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1166016007527 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1166016007528 GAF domain; Region: GAF; pfam01590 1166016007529 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1166016007530 nucleotidyl binding site; other site 1166016007531 metal binding site [ion binding]; metal-binding site 1166016007532 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016007533 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1166016007534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016007535 ATP binding site [chemical binding]; other site 1166016007536 putative Mg++ binding site [ion binding]; other site 1166016007537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016007538 nucleotide binding region [chemical binding]; other site 1166016007539 ATP-binding site [chemical binding]; other site 1166016007540 Helicase associated domain (HA2); Region: HA2; pfam04408 1166016007541 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1166016007542 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1166016007543 azoreductase; Reviewed; Region: PRK00170 1166016007544 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166016007545 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1166016007546 hypothetical protein; Provisional; Region: PRK10695 1166016007547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016007548 PAS domain; Region: PAS_9; pfam13426 1166016007549 putative active site [active] 1166016007550 heme pocket [chemical binding]; other site 1166016007551 HAMP domain; Region: HAMP; pfam00672 1166016007552 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016007553 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016007554 dimer interface [polypeptide binding]; other site 1166016007555 putative CheW interface [polypeptide binding]; other site 1166016007556 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1166016007557 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1166016007558 putative ligand binding site [chemical binding]; other site 1166016007559 putative NAD binding site [chemical binding]; other site 1166016007560 catalytic site [active] 1166016007561 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1166016007562 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1166016007563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016007564 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1166016007565 DNA binding site [nucleotide binding] 1166016007566 active site 1166016007567 Int/Topo IB signature motif; other site 1166016007568 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1166016007569 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1166016007570 Ligand Binding Site [chemical binding]; other site 1166016007571 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1166016007572 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1166016007573 Cl binding site [ion binding]; other site 1166016007574 oligomer interface [polypeptide binding]; other site 1166016007575 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166016007576 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166016007577 peptide binding site [polypeptide binding]; other site 1166016007578 murein peptide amidase A; Provisional; Region: PRK10602 1166016007579 active site 1166016007580 Zn binding site [ion binding]; other site 1166016007581 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1166016007582 dimer interface [polypeptide binding]; other site 1166016007583 catalytic triad [active] 1166016007584 peroxidatic and resolving cysteines [active] 1166016007585 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1166016007586 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1166016007587 putative aromatic amino acid binding site; other site 1166016007588 PAS domain; Region: PAS; smart00091 1166016007589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016007590 Walker A motif; other site 1166016007591 ATP binding site [chemical binding]; other site 1166016007592 Walker B motif; other site 1166016007593 arginine finger; other site 1166016007594 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 1166016007595 hypothetical protein; Provisional; Region: PRK08201 1166016007596 putative metal binding site [ion binding]; other site 1166016007597 putative dimer interface [polypeptide binding]; other site 1166016007598 hypothetical protein; Provisional; Region: PRK05415 1166016007599 Domain of unknown function (DUF697); Region: DUF697; cl12064 1166016007600 Predicted ATPase [General function prediction only]; Region: COG3106 1166016007601 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1166016007602 phage shock protein C; Region: phageshock_pspC; TIGR02978 1166016007603 phage shock protein B; Provisional; Region: pspB; PRK09458 1166016007604 phage shock protein PspA; Provisional; Region: PRK10698 1166016007605 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1166016007606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016007607 Walker A motif; other site 1166016007608 ATP binding site [chemical binding]; other site 1166016007609 Walker B motif; other site 1166016007610 arginine finger; other site 1166016007611 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166016007612 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1166016007613 Cellulose binding domain; Region: CBM_3; pfam00942 1166016007614 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1166016007615 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166016007616 peptide binding site [polypeptide binding]; other site 1166016007617 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1166016007618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016007619 putative PBP binding loops; other site 1166016007620 dimer interface [polypeptide binding]; other site 1166016007621 ABC-ATPase subunit interface; other site 1166016007622 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1166016007623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016007624 dimer interface [polypeptide binding]; other site 1166016007625 conserved gate region; other site 1166016007626 putative PBP binding loops; other site 1166016007627 ABC-ATPase subunit interface; other site 1166016007628 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1166016007629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016007630 Walker A/P-loop; other site 1166016007631 ATP binding site [chemical binding]; other site 1166016007632 Q-loop/lid; other site 1166016007633 ABC transporter signature motif; other site 1166016007634 Walker B; other site 1166016007635 D-loop; other site 1166016007636 H-loop/switch region; other site 1166016007637 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016007638 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1166016007639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016007640 Walker A/P-loop; other site 1166016007641 ATP binding site [chemical binding]; other site 1166016007642 Q-loop/lid; other site 1166016007643 ABC transporter signature motif; other site 1166016007644 Walker B; other site 1166016007645 D-loop; other site 1166016007646 H-loop/switch region; other site 1166016007647 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016007648 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1166016007649 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1166016007650 NAD binding site [chemical binding]; other site 1166016007651 homotetramer interface [polypeptide binding]; other site 1166016007652 homodimer interface [polypeptide binding]; other site 1166016007653 substrate binding site [chemical binding]; other site 1166016007654 active site 1166016007655 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166016007656 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166016007657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016007658 putative DNA binding site [nucleotide binding]; other site 1166016007659 putative Zn2+ binding site [ion binding]; other site 1166016007660 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1166016007661 ApbE family; Region: ApbE; pfam02424 1166016007662 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166016007663 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1166016007664 putative active site [active] 1166016007665 putative FMN binding site [chemical binding]; other site 1166016007666 putative substrate binding site [chemical binding]; other site 1166016007667 putative catalytic residue [active] 1166016007668 FMN-binding domain; Region: FMN_bind; cl01081 1166016007669 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1166016007670 L-aspartate oxidase; Provisional; Region: PRK06175 1166016007671 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1166016007672 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1166016007673 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1166016007674 putative active site [active] 1166016007675 putative catalytic site [active] 1166016007676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016007677 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016007678 putative substrate translocation pore; other site 1166016007679 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016007680 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016007681 DNA binding site [nucleotide binding] 1166016007682 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1166016007683 ligand binding site [chemical binding]; other site 1166016007684 dimerization interface [polypeptide binding]; other site 1166016007685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016007686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016007687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016007688 dimerization interface [polypeptide binding]; other site 1166016007689 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1166016007690 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1166016007691 putative molybdopterin cofactor binding site [chemical binding]; other site 1166016007692 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1166016007693 putative molybdopterin cofactor binding site; other site 1166016007694 exoribonuclease II; Provisional; Region: PRK05054 1166016007695 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1166016007696 RNB domain; Region: RNB; pfam00773 1166016007697 S1 RNA binding domain; Region: S1; pfam00575 1166016007698 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016007699 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016007700 active site 1166016007701 catalytic tetrad [active] 1166016007702 carbon starvation protein A; Provisional; Region: PRK15015 1166016007703 Carbon starvation protein CstA; Region: CstA; pfam02554 1166016007704 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1166016007705 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1166016007706 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016007707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016007708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016007709 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1166016007710 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1166016007711 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1166016007712 galactoside permease; Reviewed; Region: lacY; PRK09528 1166016007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016007714 putative substrate translocation pore; other site 1166016007715 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1166016007716 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1166016007717 intersubunit interface [polypeptide binding]; other site 1166016007718 active site 1166016007719 Zn2+ binding site [ion binding]; other site 1166016007720 lipoprotein; Provisional; Region: PRK10540 1166016007721 translation initiation factor Sui1; Validated; Region: PRK06824 1166016007722 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1166016007723 putative rRNA binding site [nucleotide binding]; other site 1166016007724 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1166016007725 active site 1166016007726 dimer interface [polypeptide binding]; other site 1166016007727 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1166016007728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1166016007729 TPR motif; other site 1166016007730 binding surface 1166016007731 Predicted membrane protein [Function unknown]; Region: COG3771 1166016007732 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1166016007733 MarR family; Region: MarR_2; pfam12802 1166016007734 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1166016007735 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1166016007736 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1166016007737 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1166016007738 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1166016007739 N- and C-terminal domain interface [polypeptide binding]; other site 1166016007740 active site 1166016007741 MgATP binding site [chemical binding]; other site 1166016007742 catalytic site [active] 1166016007743 metal binding site [ion binding]; metal-binding site 1166016007744 putative homotetramer interface [polypeptide binding]; other site 1166016007745 putative homodimer interface [polypeptide binding]; other site 1166016007746 glycerol binding site [chemical binding]; other site 1166016007747 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1166016007748 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166016007749 PYR/PP interface [polypeptide binding]; other site 1166016007750 dimer interface [polypeptide binding]; other site 1166016007751 TPP binding site [chemical binding]; other site 1166016007752 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166016007753 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166016007754 TPP-binding site [chemical binding]; other site 1166016007755 dimer interface [polypeptide binding]; other site 1166016007756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016007757 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016007758 TM-ABC transporter signature motif; other site 1166016007759 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166016007760 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016007761 Walker A/P-loop; other site 1166016007762 ATP binding site [chemical binding]; other site 1166016007763 Q-loop/lid; other site 1166016007764 ABC transporter signature motif; other site 1166016007765 Walker B; other site 1166016007766 D-loop; other site 1166016007767 H-loop/switch region; other site 1166016007768 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016007769 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 1166016007770 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1166016007771 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1166016007772 ligand binding site [chemical binding]; other site 1166016007773 dimerization interface [polypeptide binding]; other site 1166016007774 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166016007775 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1166016007776 active site 1166016007777 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1166016007778 dimerization interface [polypeptide binding]; other site 1166016007779 active site 1166016007780 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1166016007781 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1166016007782 peptide binding site [polypeptide binding]; other site 1166016007783 aconitate hydratase; Validated; Region: PRK09277 1166016007784 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1166016007785 substrate binding site [chemical binding]; other site 1166016007786 ligand binding site [chemical binding]; other site 1166016007787 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1166016007788 substrate binding site [chemical binding]; other site 1166016007789 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1166016007790 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1166016007791 glutathionine S-transferase; Provisional; Region: PRK10542 1166016007792 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1166016007793 C-terminal domain interface [polypeptide binding]; other site 1166016007794 GSH binding site (G-site) [chemical binding]; other site 1166016007795 dimer interface [polypeptide binding]; other site 1166016007796 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1166016007797 N-terminal domain interface [polypeptide binding]; other site 1166016007798 dimer interface [polypeptide binding]; other site 1166016007799 substrate binding pocket (H-site) [chemical binding]; other site 1166016007800 pyridoxamine kinase; Validated; Region: PRK05756 1166016007801 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1166016007802 dimer interface [polypeptide binding]; other site 1166016007803 pyridoxal binding site [chemical binding]; other site 1166016007804 ATP binding site [chemical binding]; other site 1166016007805 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1166016007806 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1166016007807 active site 1166016007808 HIGH motif; other site 1166016007809 dimer interface [polypeptide binding]; other site 1166016007810 KMSKS motif; other site 1166016007811 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016007812 RNA binding surface [nucleotide binding]; other site 1166016007813 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1166016007814 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1166016007815 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1166016007816 lysozyme inhibitor; Provisional; Region: PRK11372 1166016007817 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1166016007818 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1166016007819 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1166016007820 transcriptional regulator SlyA; Provisional; Region: PRK03573 1166016007821 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1166016007822 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1166016007823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166016007824 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1166016007825 dimer interface [polypeptide binding]; other site 1166016007826 active site 1166016007827 metal binding site [ion binding]; metal-binding site 1166016007828 glutathione binding site [chemical binding]; other site 1166016007829 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1166016007830 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1166016007831 dimer interface [polypeptide binding]; other site 1166016007832 catalytic site [active] 1166016007833 putative active site [active] 1166016007834 putative substrate binding site [chemical binding]; other site 1166016007835 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1166016007836 putative GSH binding site [chemical binding]; other site 1166016007837 catalytic residues [active] 1166016007838 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1166016007839 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166016007840 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1166016007841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016007842 DNA binding site [nucleotide binding] 1166016007843 domain linker motif; other site 1166016007844 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1166016007845 dimerization interface [polypeptide binding]; other site 1166016007846 ligand binding site [chemical binding]; other site 1166016007847 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1166016007848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016007849 S-adenosylmethionine binding site [chemical binding]; other site 1166016007850 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1166016007851 Lumazine binding domain; Region: Lum_binding; pfam00677 1166016007852 Lumazine binding domain; Region: Lum_binding; pfam00677 1166016007853 multidrug efflux protein; Reviewed; Region: PRK01766 1166016007854 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1166016007855 cation binding site [ion binding]; other site 1166016007856 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1166016007857 L-lactate permease; Region: Lactate_perm; cl00701 1166016007858 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1166016007859 Cysteine-rich domain; Region: CCG; pfam02754 1166016007860 Cysteine-rich domain; Region: CCG; pfam02754 1166016007861 iron-sulfur cluster-binding protein; Region: TIGR00273 1166016007862 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1166016007863 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016007864 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1166016007865 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1166016007866 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1166016007867 aspartate racemase; Region: asp_race; TIGR00035 1166016007868 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1166016007869 active site 1 [active] 1166016007870 dimer interface [polypeptide binding]; other site 1166016007871 hexamer interface [polypeptide binding]; other site 1166016007872 active site 2 [active] 1166016007873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016007874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016007875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016007876 dimerization interface [polypeptide binding]; other site 1166016007877 Predicted permeases [General function prediction only]; Region: COG0679 1166016007878 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166016007879 beta-galactosidase; Region: BGL; TIGR03356 1166016007880 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1166016007881 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016007882 active site turn [active] 1166016007883 phosphorylation site [posttranslational modification] 1166016007884 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016007885 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1166016007886 HPr interaction site; other site 1166016007887 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166016007888 active site 1166016007889 phosphorylation site [posttranslational modification] 1166016007890 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1166016007891 CAT RNA binding domain; Region: CAT_RBD; smart01061 1166016007892 PRD domain; Region: PRD; pfam00874 1166016007893 PRD domain; Region: PRD; pfam00874 1166016007894 urea carboxylase; Region: urea_carbox; TIGR02712 1166016007895 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166016007896 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1166016007897 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1166016007898 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1166016007899 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1166016007900 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1166016007901 carboxyltransferase (CT) interaction site; other site 1166016007902 biotinylation site [posttranslational modification]; other site 1166016007903 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1166016007904 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1166016007905 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1166016007906 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1166016007907 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1166016007908 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016007909 Walker A/P-loop; other site 1166016007910 ATP binding site [chemical binding]; other site 1166016007911 Q-loop/lid; other site 1166016007912 ABC transporter signature motif; other site 1166016007913 Walker B; other site 1166016007914 D-loop; other site 1166016007915 H-loop/switch region; other site 1166016007916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1166016007917 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1166016007918 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1166016007919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166016007920 MarR family; Region: MarR_2; cl17246 1166016007921 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 1166016007922 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1166016007923 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1166016007924 dimer interface [polypeptide binding]; other site 1166016007925 active site 1166016007926 heme binding site [chemical binding]; other site 1166016007927 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1166016007928 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1166016007929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016007930 Transposase; Region: HTH_Tnp_1; pfam01527 1166016007931 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1166016007932 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1166016007933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016007934 Walker A motif; other site 1166016007935 ATP binding site [chemical binding]; other site 1166016007936 Walker B motif; other site 1166016007937 arginine finger; other site 1166016007938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1166016007939 PAAR motif; Region: PAAR_motif; pfam05488 1166016007940 RHS Repeat; Region: RHS_repeat; cl11982 1166016007941 RHS Repeat; Region: RHS_repeat; pfam05593 1166016007942 RHS Repeat; Region: RHS_repeat; pfam05593 1166016007943 RHS Repeat; Region: RHS_repeat; pfam05593 1166016007944 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016007945 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166016007946 RHS Repeat; Region: RHS_repeat; cl11982 1166016007947 RHS Repeat; Region: RHS_repeat; pfam05593 1166016007948 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016007949 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1166016007950 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1166016007951 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016007952 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016007953 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016007954 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1166016007955 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1166016007956 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016007957 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1166016007958 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1166016007959 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1166016007960 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1166016007961 NAD binding site [chemical binding]; other site 1166016007962 ligand binding site [chemical binding]; other site 1166016007963 catalytic site [active] 1166016007964 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1166016007965 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1166016007966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016007967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016007968 putative substrate translocation pore; other site 1166016007969 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1166016007970 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1166016007971 transcriptional regulator NarP; Provisional; Region: PRK10403 1166016007972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016007973 active site 1166016007974 phosphorylation site [posttranslational modification] 1166016007975 intermolecular recognition site; other site 1166016007976 dimerization interface [polypeptide binding]; other site 1166016007977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016007978 DNA binding residues [nucleotide binding] 1166016007979 dimerization interface [polypeptide binding]; other site 1166016007980 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1166016007981 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1166016007982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016007983 dimerization interface [polypeptide binding]; other site 1166016007984 Histidine kinase; Region: HisKA_3; pfam07730 1166016007985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016007986 ATP binding site [chemical binding]; other site 1166016007987 Mg2+ binding site [ion binding]; other site 1166016007988 G-X-G motif; other site 1166016007989 ferredoxin-type protein; Provisional; Region: PRK10194 1166016007990 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1166016007991 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1166016007992 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1166016007993 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1166016007994 [4Fe-4S] binding site [ion binding]; other site 1166016007995 molybdopterin cofactor binding site; other site 1166016007996 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1166016007997 molybdopterin cofactor binding site; other site 1166016007998 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1166016007999 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1166016008000 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1166016008001 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016008002 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1166016008003 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1166016008004 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1166016008005 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1166016008006 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1166016008007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016008008 binding surface 1166016008009 TPR motif; other site 1166016008010 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1166016008011 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1166016008012 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1166016008013 catalytic residues [active] 1166016008014 central insert; other site 1166016008015 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1166016008016 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1166016008017 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1166016008018 heme exporter protein CcmC; Region: ccmC; TIGR01191 1166016008019 heme exporter protein CcmB; Region: ccmB; TIGR01190 1166016008020 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1166016008021 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1166016008022 Walker A/P-loop; other site 1166016008023 ATP binding site [chemical binding]; other site 1166016008024 Q-loop/lid; other site 1166016008025 ABC transporter signature motif; other site 1166016008026 Walker B; other site 1166016008027 D-loop; other site 1166016008028 H-loop/switch region; other site 1166016008029 TPR repeat; Region: TPR_11; pfam13414 1166016008030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016008031 binding surface 1166016008032 TPR motif; other site 1166016008033 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1166016008034 heme lyase subunit NrfE; Provisional; Region: PRK10369 1166016008035 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1166016008036 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1166016008037 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1166016008038 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1166016008039 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1166016008040 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1166016008041 active site 1166016008042 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1166016008043 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1166016008044 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1166016008045 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1166016008046 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016008047 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1166016008048 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016008049 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1166016008050 beta-galactosidase; Region: BGL; TIGR03356 1166016008051 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1166016008052 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016008053 active site turn [active] 1166016008054 phosphorylation site [posttranslational modification] 1166016008055 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016008056 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1166016008057 HPr interaction site; other site 1166016008058 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1166016008059 active site 1166016008060 phosphorylation site [posttranslational modification] 1166016008061 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1166016008062 CAT RNA binding domain; Region: CAT_RBD; smart01061 1166016008063 PRD domain; Region: PRD; pfam00874 1166016008064 PRD domain; Region: PRD; pfam00874 1166016008065 pyruvate kinase; Provisional; Region: PRK09206 1166016008066 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1166016008067 domain interfaces; other site 1166016008068 active site 1166016008069 murein lipoprotein; Provisional; Region: PRK15396 1166016008070 L,D-transpeptidase; Provisional; Region: PRK10190 1166016008071 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1166016008072 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1166016008073 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1166016008074 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1166016008075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016008076 catalytic residue [active] 1166016008077 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1166016008078 FeS assembly protein SufD; Region: sufD; TIGR01981 1166016008079 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1166016008080 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1166016008081 Walker A/P-loop; other site 1166016008082 ATP binding site [chemical binding]; other site 1166016008083 Q-loop/lid; other site 1166016008084 ABC transporter signature motif; other site 1166016008085 Walker B; other site 1166016008086 D-loop; other site 1166016008087 H-loop/switch region; other site 1166016008088 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1166016008089 putative ABC transporter; Region: ycf24; CHL00085 1166016008090 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1166016008091 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1166016008092 CoenzymeA binding site [chemical binding]; other site 1166016008093 subunit interaction site [polypeptide binding]; other site 1166016008094 PHB binding site; other site 1166016008095 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1166016008096 FAD binding domain; Region: FAD_binding_4; pfam01565 1166016008097 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1166016008098 putative inner membrane protein; Provisional; Region: PRK10983 1166016008099 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1166016008100 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1166016008101 ApbE family; Region: ApbE; pfam02424 1166016008102 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1166016008103 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1166016008104 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1166016008105 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1166016008106 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1166016008107 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1166016008108 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166016008109 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1166016008110 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1166016008111 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1166016008112 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1166016008113 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1166016008114 putative hemin binding site; other site 1166016008115 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016008116 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016008117 ABC-ATPase subunit interface; other site 1166016008118 dimer interface [polypeptide binding]; other site 1166016008119 putative PBP binding regions; other site 1166016008120 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1166016008121 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016008122 Walker A/P-loop; other site 1166016008123 ATP binding site [chemical binding]; other site 1166016008124 Q-loop/lid; other site 1166016008125 ABC transporter signature motif; other site 1166016008126 Walker B; other site 1166016008127 D-loop; other site 1166016008128 H-loop/switch region; other site 1166016008129 hypothetical protein; Validated; Region: PRK00029 1166016008130 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1166016008131 EAL domain; Region: EAL; pfam00563 1166016008132 high-affinity gluconate transporter; Provisional; Region: PRK14984 1166016008133 gluconate transporter; Region: gntP; TIGR00791 1166016008134 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1166016008135 ATP-binding site [chemical binding]; other site 1166016008136 Gluconate-6-phosphate binding site [chemical binding]; other site 1166016008137 Shikimate kinase; Region: SKI; pfam01202 1166016008138 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1166016008139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016008140 DNA binding site [nucleotide binding] 1166016008141 domain linker motif; other site 1166016008142 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1166016008143 putative ligand binding site [chemical binding]; other site 1166016008144 putative dimerization interface [polypeptide binding]; other site 1166016008145 phosphogluconate dehydratase; Validated; Region: PRK09054 1166016008146 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1166016008147 NlpC/P60 family; Region: NLPC_P60; pfam00877 1166016008148 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1166016008149 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016008150 Walker A/P-loop; other site 1166016008151 ATP binding site [chemical binding]; other site 1166016008152 Q-loop/lid; other site 1166016008153 ABC transporter signature motif; other site 1166016008154 Walker B; other site 1166016008155 D-loop; other site 1166016008156 H-loop/switch region; other site 1166016008157 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1166016008158 catalytic residues [active] 1166016008159 dimer interface [polypeptide binding]; other site 1166016008160 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016008161 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016008162 ABC-ATPase subunit interface; other site 1166016008163 dimer interface [polypeptide binding]; other site 1166016008164 putative PBP binding regions; other site 1166016008165 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166016008166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016008167 S-adenosylmethionine binding site [chemical binding]; other site 1166016008168 Cupin domain; Region: Cupin_2; cl17218 1166016008169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1166016008170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1166016008171 ligand binding site [chemical binding]; other site 1166016008172 flexible hinge region; other site 1166016008173 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1166016008174 NAD-dependent deacetylase; Provisional; Region: PRK00481 1166016008175 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1166016008176 NAD+ binding site [chemical binding]; other site 1166016008177 substrate binding site [chemical binding]; other site 1166016008178 Zn binding site [ion binding]; other site 1166016008179 fructokinase; Reviewed; Region: PRK09557 1166016008180 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166016008181 nucleotide binding site [chemical binding]; other site 1166016008182 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1166016008183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166016008184 FtsX-like permease family; Region: FtsX; pfam02687 1166016008185 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1166016008186 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166016008187 Walker A/P-loop; other site 1166016008188 ATP binding site [chemical binding]; other site 1166016008189 Q-loop/lid; other site 1166016008190 ABC transporter signature motif; other site 1166016008191 Walker B; other site 1166016008192 D-loop; other site 1166016008193 H-loop/switch region; other site 1166016008194 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1166016008195 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166016008196 FtsX-like permease family; Region: FtsX; pfam02687 1166016008197 transcription-repair coupling factor; Provisional; Region: PRK10689 1166016008198 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1166016008199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016008200 ATP binding site [chemical binding]; other site 1166016008201 putative Mg++ binding site [ion binding]; other site 1166016008202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016008203 nucleotide binding region [chemical binding]; other site 1166016008204 ATP-binding site [chemical binding]; other site 1166016008205 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1166016008206 putative chaperone; Provisional; Region: PRK11678 1166016008207 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1166016008208 nucleotide binding site [chemical binding]; other site 1166016008209 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1166016008210 SBD interface [polypeptide binding]; other site 1166016008211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016008212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016008213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016008214 putative substrate translocation pore; other site 1166016008215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016008216 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166016008217 hypothetical protein; Provisional; Region: PRK11280 1166016008218 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1166016008219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016008220 hypothetical protein; Provisional; Region: PRK04940 1166016008221 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1166016008222 beta-hexosaminidase; Provisional; Region: PRK05337 1166016008223 thiamine kinase; Region: ycfN_thiK; TIGR02721 1166016008224 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1166016008225 active site 1166016008226 substrate binding site [chemical binding]; other site 1166016008227 ATP binding site [chemical binding]; other site 1166016008228 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1166016008229 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1166016008230 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1166016008231 putative dimer interface [polypeptide binding]; other site 1166016008232 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1166016008233 nucleotide binding site/active site [active] 1166016008234 HIT family signature motif; other site 1166016008235 catalytic residue [active] 1166016008236 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1166016008237 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016008238 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016008239 active site turn [active] 1166016008240 phosphorylation site [posttranslational modification] 1166016008241 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1166016008242 active site 1166016008243 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1166016008244 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1166016008245 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1166016008246 thymidylate kinase; Validated; Region: tmk; PRK00698 1166016008247 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1166016008248 TMP-binding site; other site 1166016008249 ATP-binding site [chemical binding]; other site 1166016008250 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1166016008251 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1166016008252 dimerization interface [polypeptide binding]; other site 1166016008253 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1166016008254 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1166016008255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016008256 catalytic residue [active] 1166016008257 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166016008258 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1166016008259 intersubunit interface [polypeptide binding]; other site 1166016008260 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1166016008261 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166016008262 dimer interface [polypeptide binding]; other site 1166016008263 active site 1166016008264 acyl carrier protein; Provisional; Region: acpP; PRK00982 1166016008265 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1166016008266 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1166016008267 NAD(P) binding site [chemical binding]; other site 1166016008268 homotetramer interface [polypeptide binding]; other site 1166016008269 homodimer interface [polypeptide binding]; other site 1166016008270 active site 1166016008271 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1166016008272 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1166016008273 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1166016008274 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1166016008275 dimer interface [polypeptide binding]; other site 1166016008276 active site 1166016008277 CoA binding pocket [chemical binding]; other site 1166016008278 putative phosphate acyltransferase; Provisional; Region: PRK05331 1166016008279 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1166016008280 hypothetical protein; Provisional; Region: PRK11193 1166016008281 Maf-like protein; Region: Maf; pfam02545 1166016008282 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1166016008283 active site 1166016008284 dimer interface [polypeptide binding]; other site 1166016008285 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1166016008286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016008287 RNA binding surface [nucleotide binding]; other site 1166016008288 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1166016008289 active site 1166016008290 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1166016008291 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1166016008292 homodimer interface [polypeptide binding]; other site 1166016008293 oligonucleotide binding site [chemical binding]; other site 1166016008294 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1166016008295 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1166016008296 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1166016008297 active site 1166016008298 substrate binding pocket [chemical binding]; other site 1166016008299 dimer interface [polypeptide binding]; other site 1166016008300 DNA damage-inducible protein I; Provisional; Region: PRK10597 1166016008301 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1166016008302 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1166016008303 hypothetical protein; Provisional; Region: PRK03757 1166016008304 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1166016008305 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1166016008306 active site residue [active] 1166016008307 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166016008308 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1166016008309 active site 1166016008310 FMN binding site [chemical binding]; other site 1166016008311 substrate binding site [chemical binding]; other site 1166016008312 homotetramer interface [polypeptide binding]; other site 1166016008313 catalytic residue [active] 1166016008314 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1166016008315 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166016008316 putative acyl-acceptor binding pocket; other site 1166016008317 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1166016008318 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1166016008319 Ligand binding site; other site 1166016008320 DXD motif; other site 1166016008321 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1166016008322 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1166016008323 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1166016008324 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1166016008325 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1166016008326 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016008327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016008328 dimerization interface [polypeptide binding]; other site 1166016008329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016008330 dimer interface [polypeptide binding]; other site 1166016008331 putative CheW interface [polypeptide binding]; other site 1166016008332 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1166016008333 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166016008334 Ligand Binding Site [chemical binding]; other site 1166016008335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016008336 Coenzyme A binding pocket [chemical binding]; other site 1166016008337 Isochorismatase family; Region: Isochorismatase; pfam00857 1166016008338 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1166016008339 catalytic triad [active] 1166016008340 conserved cis-peptide bond; other site 1166016008341 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1166016008342 nudix motif; other site 1166016008343 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1166016008344 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016008345 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016008346 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1166016008347 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1166016008348 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1166016008349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016008350 Transposase; Region: HTH_Tnp_1; pfam01527 1166016008351 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1166016008352 YccA-like proteins; Region: YccA_like; cd10433 1166016008353 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1166016008354 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1166016008355 acylphosphatase; Provisional; Region: PRK14426 1166016008356 heat shock protein HspQ; Provisional; Region: PRK14129 1166016008357 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1166016008358 hypothetical protein; Provisional; Region: PRK03641 1166016008359 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 1166016008360 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1166016008361 active site 1166016008362 dimer interfaces [polypeptide binding]; other site 1166016008363 catalytic residues [active] 1166016008364 DNA helicase IV; Provisional; Region: helD; PRK11054 1166016008365 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1166016008366 Part of AAA domain; Region: AAA_19; pfam13245 1166016008367 Family description; Region: UvrD_C_2; pfam13538 1166016008368 Predicted membrane protein [Function unknown]; Region: COG3304 1166016008369 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1166016008370 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1166016008371 TIGR01666 family membrane protein; Region: YCCS 1166016008372 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1166016008373 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1166016008374 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1166016008375 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1166016008376 SOS cell division inhibitor; Provisional; Region: PRK10595 1166016008377 outer membrane protein A; Reviewed; Region: PRK10808 1166016008378 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1166016008379 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166016008380 ligand binding site [chemical binding]; other site 1166016008381 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1166016008382 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1166016008383 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1166016008384 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1166016008385 active site 1 [active] 1166016008386 dimer interface [polypeptide binding]; other site 1166016008387 active site 2 [active] 1166016008388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1166016008389 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1166016008390 putative metal binding site [ion binding]; other site 1166016008391 hypothetical protein; Provisional; Region: PRK09273 1166016008392 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1166016008393 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1166016008394 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1166016008395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1166016008396 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166016008397 DNA-binding site [nucleotide binding]; DNA binding site 1166016008398 RNA-binding motif; other site 1166016008399 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1166016008400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1166016008401 active site residue [active] 1166016008402 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1166016008403 MATE family multidrug exporter; Provisional; Region: PRK10189 1166016008404 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1166016008405 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1166016008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016008407 putative substrate translocation pore; other site 1166016008408 outer membrane protein X; Provisional; Region: ompX; PRK09408 1166016008409 threonine and homoserine efflux system; Provisional; Region: PRK10532 1166016008410 EamA-like transporter family; Region: EamA; pfam00892 1166016008411 topology modulation protein; Reviewed; Region: PRK08118 1166016008412 AAA domain; Region: AAA_17; pfam13207 1166016008413 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1166016008414 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1166016008415 dimerization interface [polypeptide binding]; other site 1166016008416 DPS ferroxidase diiron center [ion binding]; other site 1166016008417 ion pore; other site 1166016008418 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1166016008419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016008420 substrate binding pocket [chemical binding]; other site 1166016008421 membrane-bound complex binding site; other site 1166016008422 hinge residues; other site 1166016008423 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016008424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016008425 dimer interface [polypeptide binding]; other site 1166016008426 conserved gate region; other site 1166016008427 putative PBP binding loops; other site 1166016008428 ABC-ATPase subunit interface; other site 1166016008429 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1166016008430 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016008431 Walker A/P-loop; other site 1166016008432 ATP binding site [chemical binding]; other site 1166016008433 Q-loop/lid; other site 1166016008434 ABC transporter signature motif; other site 1166016008435 Walker B; other site 1166016008436 D-loop; other site 1166016008437 H-loop/switch region; other site 1166016008438 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1166016008439 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 1166016008440 active site 1166016008441 Zn binding site [ion binding]; other site 1166016008442 glycosyl transferase family protein; Provisional; Region: PRK08136 1166016008443 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1166016008444 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1166016008445 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1166016008446 catalytic residues [active] 1166016008447 catalytic nucleophile [active] 1166016008448 Presynaptic Site I dimer interface [polypeptide binding]; other site 1166016008449 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1166016008450 Synaptic Flat tetramer interface [polypeptide binding]; other site 1166016008451 Synaptic Site I dimer interface [polypeptide binding]; other site 1166016008452 DNA binding site [nucleotide binding] 1166016008453 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1166016008454 DNA-binding interface [nucleotide binding]; DNA binding site 1166016008455 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166016008456 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1166016008457 Phage Tail Collar Domain; Region: Collar; pfam07484 1166016008458 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1166016008459 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1166016008460 Baseplate J-like protein; Region: Baseplate_J; cl01294 1166016008461 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1166016008462 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1166016008463 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1166016008464 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1166016008465 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1166016008466 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1166016008467 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1166016008468 Phage tail tube protein FII; Region: Phage_tube; cl01390 1166016008469 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1166016008470 Gp37 protein; Region: Gp37; pfam09646 1166016008471 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016008472 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016008473 catalytic residue [active] 1166016008474 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1166016008475 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1166016008476 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1166016008477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016008478 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016008479 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1166016008480 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1166016008481 Walker A/P-loop; other site 1166016008482 ATP binding site [chemical binding]; other site 1166016008483 Q-loop/lid; other site 1166016008484 ABC transporter signature motif; other site 1166016008485 Walker B; other site 1166016008486 D-loop; other site 1166016008487 H-loop/switch region; other site 1166016008488 Protease inhibitor Inh; Region: Inh; pfam02974 1166016008489 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1166016008490 active site 1166016008491 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1166016008492 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1166016008493 DEAD_2; Region: DEAD_2; pfam06733 1166016008494 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1166016008495 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016008496 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016008497 LysE type translocator; Region: LysE; cl00565 1166016008498 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1166016008499 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1166016008500 active site 1166016008501 metal binding site [ion binding]; metal-binding site 1166016008502 nudix motif; other site 1166016008503 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1166016008504 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1166016008505 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1166016008506 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1166016008507 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016008508 inhibitor-cofactor binding pocket; inhibition site 1166016008509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016008510 catalytic residue [active] 1166016008511 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1166016008512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166016008513 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1166016008514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016008515 Walker A/P-loop; other site 1166016008516 ATP binding site [chemical binding]; other site 1166016008517 Q-loop/lid; other site 1166016008518 ABC transporter signature motif; other site 1166016008519 Walker B; other site 1166016008520 D-loop; other site 1166016008521 H-loop/switch region; other site 1166016008522 TOBE domain; Region: TOBE_2; pfam08402 1166016008523 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1166016008524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016008525 putative PBP binding loops; other site 1166016008526 dimer interface [polypeptide binding]; other site 1166016008527 ABC-ATPase subunit interface; other site 1166016008528 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1166016008529 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166016008530 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1166016008531 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016008532 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1166016008533 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1166016008534 putative C-terminal domain interface [polypeptide binding]; other site 1166016008535 putative GSH binding site (G-site) [chemical binding]; other site 1166016008536 putative dimer interface [polypeptide binding]; other site 1166016008537 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1166016008538 putative substrate binding pocket (H-site) [chemical binding]; other site 1166016008539 putative N-terminal domain interface [polypeptide binding]; other site 1166016008540 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1166016008541 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1166016008542 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 1166016008543 FMN-binding domain; Region: FMN_bind; cl01081 1166016008544 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1166016008545 putative active site [active] 1166016008546 putative metal binding residues [ion binding]; other site 1166016008547 signature motif; other site 1166016008548 putative triphosphate binding site [ion binding]; other site 1166016008549 dimer interface [polypeptide binding]; other site 1166016008550 aminopeptidase B; Provisional; Region: PRK05015 1166016008551 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1166016008552 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1166016008553 S-methylmethionine transporter; Provisional; Region: PRK11387 1166016008554 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1166016008555 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1166016008556 FMN binding site [chemical binding]; other site 1166016008557 active site 1166016008558 catalytic residues [active] 1166016008559 substrate binding site [chemical binding]; other site 1166016008560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1166016008561 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166016008562 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1166016008563 peptide binding site [polypeptide binding]; other site 1166016008564 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1166016008565 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1166016008566 metal binding site [ion binding]; metal-binding site 1166016008567 dimer interface [polypeptide binding]; other site 1166016008568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016008569 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016008570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016008571 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166016008572 EamA-like transporter family; Region: EamA; pfam00892 1166016008573 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1166016008574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1166016008575 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1166016008576 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1166016008577 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1166016008578 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166016008579 ATP binding site [chemical binding]; other site 1166016008580 Mg++ binding site [ion binding]; other site 1166016008581 motif III; other site 1166016008582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016008583 nucleotide binding region [chemical binding]; other site 1166016008584 ATP-binding site [chemical binding]; other site 1166016008585 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1166016008586 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1166016008587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016008588 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016008589 Walker A/P-loop; other site 1166016008590 ATP binding site [chemical binding]; other site 1166016008591 Q-loop/lid; other site 1166016008592 ABC transporter signature motif; other site 1166016008593 Walker B; other site 1166016008594 D-loop; other site 1166016008595 H-loop/switch region; other site 1166016008596 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166016008597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016008598 ABC-ATPase subunit interface; other site 1166016008599 dimer interface [polypeptide binding]; other site 1166016008600 putative PBP binding regions; other site 1166016008601 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1166016008602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016008603 ABC-ATPase subunit interface; other site 1166016008604 dimer interface [polypeptide binding]; other site 1166016008605 putative PBP binding regions; other site 1166016008606 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1166016008607 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1166016008608 siderophore binding site; other site 1166016008609 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1166016008610 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016008611 N-terminal plug; other site 1166016008612 ligand-binding site [chemical binding]; other site 1166016008613 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1166016008614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016008615 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016008616 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1166016008617 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1166016008618 Walker A/P-loop; other site 1166016008619 ATP binding site [chemical binding]; other site 1166016008620 Q-loop/lid; other site 1166016008621 ABC transporter signature motif; other site 1166016008622 Walker B; other site 1166016008623 D-loop; other site 1166016008624 H-loop/switch region; other site 1166016008625 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1166016008626 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1166016008627 Walker A/P-loop; other site 1166016008628 ATP binding site [chemical binding]; other site 1166016008629 Q-loop/lid; other site 1166016008630 ABC transporter signature motif; other site 1166016008631 Walker B; other site 1166016008632 D-loop; other site 1166016008633 H-loop/switch region; other site 1166016008634 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166016008635 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1166016008636 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1166016008637 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1166016008638 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1166016008639 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1166016008640 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1166016008641 MoaE homodimer interface [polypeptide binding]; other site 1166016008642 MoaD interaction [polypeptide binding]; other site 1166016008643 active site residues [active] 1166016008644 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1166016008645 MoaE interaction surface [polypeptide binding]; other site 1166016008646 MoeB interaction surface [polypeptide binding]; other site 1166016008647 thiocarboxylated glycine; other site 1166016008648 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1166016008649 trimer interface [polypeptide binding]; other site 1166016008650 dimer interface [polypeptide binding]; other site 1166016008651 putative active site [active] 1166016008652 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1166016008653 MPT binding site; other site 1166016008654 trimer interface [polypeptide binding]; other site 1166016008655 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1166016008656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016008657 FeS/SAM binding site; other site 1166016008658 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1166016008659 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1166016008660 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1166016008661 phosphate binding site [ion binding]; other site 1166016008662 putative substrate binding pocket [chemical binding]; other site 1166016008663 dimer interface [polypeptide binding]; other site 1166016008664 phosphodiesterase; Provisional; Region: PRK12704 1166016008665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1166016008666 active site 1166016008667 excinuclease ABC subunit B; Provisional; Region: PRK05298 1166016008668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016008669 ATP binding site [chemical binding]; other site 1166016008670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016008671 nucleotide binding region [chemical binding]; other site 1166016008672 ATP-binding site [chemical binding]; other site 1166016008673 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1166016008674 UvrB/uvrC motif; Region: UVR; pfam02151 1166016008675 AAA domain; Region: AAA_26; pfam13500 1166016008676 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166016008677 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1166016008678 ADP binding site [chemical binding]; other site 1166016008679 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1166016008680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016008681 S-adenosylmethionine binding site [chemical binding]; other site 1166016008682 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1166016008683 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1166016008684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016008685 catalytic residue [active] 1166016008686 biotin synthase; Provisional; Region: PRK15108 1166016008687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016008688 FeS/SAM binding site; other site 1166016008689 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1166016008690 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1166016008691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016008692 inhibitor-cofactor binding pocket; inhibition site 1166016008693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016008694 catalytic residue [active] 1166016008695 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1166016008696 hypothetical protein; Provisional; Region: PRK01821 1166016008697 hypothetical protein; Provisional; Region: PRK10711 1166016008698 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1166016008699 cytidine deaminase; Provisional; Region: PRK09027 1166016008700 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1166016008701 active site 1166016008702 catalytic motif [active] 1166016008703 Zn binding site [ion binding]; other site 1166016008704 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1166016008705 active site 1166016008706 catalytic motif [active] 1166016008707 Zn binding site [ion binding]; other site 1166016008708 malate dehydrogenase; Provisional; Region: PRK13529 1166016008709 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1166016008710 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1166016008711 NAD(P) binding site [chemical binding]; other site 1166016008712 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1166016008713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016008714 dimer interface [polypeptide binding]; other site 1166016008715 conserved gate region; other site 1166016008716 putative PBP binding loops; other site 1166016008717 ABC-ATPase subunit interface; other site 1166016008718 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1166016008719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016008720 dimer interface [polypeptide binding]; other site 1166016008721 conserved gate region; other site 1166016008722 putative PBP binding loops; other site 1166016008723 ABC-ATPase subunit interface; other site 1166016008724 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1166016008725 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1166016008726 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1166016008727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016008728 Walker A/P-loop; other site 1166016008729 ATP binding site [chemical binding]; other site 1166016008730 Q-loop/lid; other site 1166016008731 ABC transporter signature motif; other site 1166016008732 Walker B; other site 1166016008733 D-loop; other site 1166016008734 H-loop/switch region; other site 1166016008735 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016008736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016008737 Walker A/P-loop; other site 1166016008738 ATP binding site [chemical binding]; other site 1166016008739 Q-loop/lid; other site 1166016008740 ABC transporter signature motif; other site 1166016008741 Walker B; other site 1166016008742 D-loop; other site 1166016008743 H-loop/switch region; other site 1166016008744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016008745 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1166016008746 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1166016008747 dimer interface [polypeptide binding]; other site 1166016008748 putative functional site; other site 1166016008749 putative MPT binding site; other site 1166016008750 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1166016008751 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1166016008752 ATP binding site [chemical binding]; other site 1166016008753 substrate interface [chemical binding]; other site 1166016008754 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1166016008755 dimer interface [polypeptide binding]; other site 1166016008756 FMN binding site [chemical binding]; other site 1166016008757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016008758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016008759 metal binding site [ion binding]; metal-binding site 1166016008760 active site 1166016008761 I-site; other site 1166016008762 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1166016008763 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1166016008764 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016008765 N-terminal plug; other site 1166016008766 ligand-binding site [chemical binding]; other site 1166016008767 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1166016008768 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1166016008769 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1166016008770 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1166016008771 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166016008772 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1166016008773 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1166016008774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016008775 dimer interface [polypeptide binding]; other site 1166016008776 conserved gate region; other site 1166016008777 putative PBP binding loops; other site 1166016008778 ABC-ATPase subunit interface; other site 1166016008779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016008780 dimer interface [polypeptide binding]; other site 1166016008781 conserved gate region; other site 1166016008782 putative PBP binding loops; other site 1166016008783 ABC-ATPase subunit interface; other site 1166016008784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016008785 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166016008786 Walker A/P-loop; other site 1166016008787 ATP binding site [chemical binding]; other site 1166016008788 Q-loop/lid; other site 1166016008789 ABC transporter signature motif; other site 1166016008790 Walker B; other site 1166016008791 D-loop; other site 1166016008792 H-loop/switch region; other site 1166016008793 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1166016008794 AAA domain; Region: AAA_33; pfam13671 1166016008795 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1166016008796 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1166016008797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016008798 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1166016008799 substrate binding site [chemical binding]; other site 1166016008800 ATP binding site [chemical binding]; other site 1166016008801 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1166016008802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1166016008803 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016008804 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016008805 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016008806 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016008807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016008808 TM-ABC transporter signature motif; other site 1166016008809 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166016008810 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016008811 Walker A/P-loop; other site 1166016008812 ATP binding site [chemical binding]; other site 1166016008813 Q-loop/lid; other site 1166016008814 ABC transporter signature motif; other site 1166016008815 Walker B; other site 1166016008816 D-loop; other site 1166016008817 H-loop/switch region; other site 1166016008818 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016008819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1166016008820 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1166016008821 ligand binding site [chemical binding]; other site 1166016008822 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016008823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016008824 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016008825 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1166016008826 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166016008827 PYR/PP interface [polypeptide binding]; other site 1166016008828 dimer interface [polypeptide binding]; other site 1166016008829 TPP binding site [chemical binding]; other site 1166016008830 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166016008831 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1166016008832 TPP-binding site; other site 1166016008833 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1166016008834 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1166016008835 tetrameric interface [polypeptide binding]; other site 1166016008836 NAD binding site [chemical binding]; other site 1166016008837 catalytic residues [active] 1166016008838 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166016008839 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166016008840 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166016008841 putative active site [active] 1166016008842 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1166016008843 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1166016008844 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1166016008845 MASE2 domain; Region: MASE2; pfam05230 1166016008846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016008847 metal binding site [ion binding]; metal-binding site 1166016008848 active site 1166016008849 I-site; other site 1166016008850 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1166016008851 peptidase domain interface [polypeptide binding]; other site 1166016008852 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1166016008853 active site 1166016008854 catalytic triad [active] 1166016008855 calcium binding site [ion binding]; other site 1166016008856 chorismate mutase; Provisional; Region: PRK08055 1166016008857 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1166016008858 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1166016008859 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1166016008860 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1166016008861 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1166016008862 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1166016008863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1166016008864 active site 1166016008865 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1166016008866 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1166016008867 substrate binding site; other site 1166016008868 tetramer interface; other site 1166016008869 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1166016008870 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1166016008871 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1166016008872 NADP binding site [chemical binding]; other site 1166016008873 active site 1166016008874 putative substrate binding site [chemical binding]; other site 1166016008875 UDP-galactopyranose mutase; Region: GLF; pfam03275 1166016008876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1166016008877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1166016008878 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1166016008879 Winged helix-turn helix; Region: HTH_29; pfam13551 1166016008880 Winged helix-turn helix; Region: HTH_33; pfam13592 1166016008881 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1166016008882 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1166016008883 active site 1166016008884 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1166016008885 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1166016008886 putative ADP-binding pocket [chemical binding]; other site 1166016008887 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 1166016008888 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1166016008889 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1166016008890 pseudaminic acid synthase; Region: PseI; TIGR03586 1166016008891 NeuB family; Region: NeuB; pfam03102 1166016008892 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1166016008893 NeuB binding interface [polypeptide binding]; other site 1166016008894 putative substrate binding site [chemical binding]; other site 1166016008895 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1166016008896 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166016008897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1166016008898 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1166016008899 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1166016008900 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1166016008901 ligand binding site; other site 1166016008902 tetramer interface; other site 1166016008903 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166016008904 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166016008905 inhibitor-cofactor binding pocket; inhibition site 1166016008906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016008907 catalytic residue [active] 1166016008908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1166016008909 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1166016008910 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1166016008911 NAD(P) binding site [chemical binding]; other site 1166016008912 homodimer interface [polypeptide binding]; other site 1166016008913 substrate binding site [chemical binding]; other site 1166016008914 active site 1166016008915 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1166016008916 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1166016008917 tyrosine kinase; Provisional; Region: PRK11519 1166016008918 Chain length determinant protein; Region: Wzz; pfam02706 1166016008919 Chain length determinant protein; Region: Wzz; cl15801 1166016008920 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1166016008921 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1166016008922 Nucleotide binding site [chemical binding]; other site 1166016008923 DTAP/Switch II; other site 1166016008924 Switch I; other site 1166016008925 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1166016008926 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1166016008927 active site 1166016008928 polysaccharide export protein Wza; Provisional; Region: PRK15078 1166016008929 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1166016008930 SLBB domain; Region: SLBB; pfam10531 1166016008931 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 1166016008932 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1166016008933 Mg++ binding site [ion binding]; other site 1166016008934 putative catalytic motif [active] 1166016008935 substrate binding site [chemical binding]; other site 1166016008936 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1166016008937 FOG: CBS domain [General function prediction only]; Region: COG0517 1166016008938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166016008939 Transporter associated domain; Region: CorC_HlyC; smart01091 1166016008940 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1166016008941 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1166016008942 putative assembly protein; Provisional; Region: PRK10833 1166016008943 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1166016008944 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1166016008945 trimer interface [polypeptide binding]; other site 1166016008946 active site 1166016008947 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1166016008948 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1166016008949 Sugar specificity; other site 1166016008950 Pyrimidine base specificity; other site 1166016008951 ATP-binding site [chemical binding]; other site 1166016008952 antiporter inner membrane protein; Provisional; Region: PRK11670 1166016008953 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1166016008954 Walker A motif; other site 1166016008955 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1166016008956 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1166016008957 active site 1166016008958 HIGH motif; other site 1166016008959 KMSKS motif; other site 1166016008960 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1166016008961 tRNA binding surface [nucleotide binding]; other site 1166016008962 anticodon binding site; other site 1166016008963 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1166016008964 dimer interface [polypeptide binding]; other site 1166016008965 putative tRNA-binding site [nucleotide binding]; other site 1166016008966 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1166016008967 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1166016008968 [4Fe-4S] binding site [ion binding]; other site 1166016008969 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1166016008970 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1166016008971 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1166016008972 molybdopterin cofactor binding site; other site 1166016008973 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1166016008974 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1166016008975 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1166016008976 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1166016008977 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1166016008978 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1166016008979 putative ligand binding site [chemical binding]; other site 1166016008980 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1166016008981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1166016008982 6-phosphogluconolactonase; Provisional; Region: PRK11028 1166016008983 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1166016008984 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1166016008985 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1166016008986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016008987 active site 1166016008988 motif I; other site 1166016008989 motif II; other site 1166016008990 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166016008991 glucokinase; Provisional; Region: glk; PRK00292 1166016008992 glucokinase, proteobacterial type; Region: glk; TIGR00749 1166016008993 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 1166016008994 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1166016008995 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1166016008996 Metal-binding active site; metal-binding site 1166016008997 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1166016008998 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1166016008999 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1166016009000 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1166016009001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016009002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016009003 DNA binding site [nucleotide binding] 1166016009004 domain linker motif; other site 1166016009005 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1166016009006 dimerization interface [polypeptide binding]; other site 1166016009007 ligand binding site [chemical binding]; other site 1166016009008 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1166016009009 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1166016009010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016009011 Walker A/P-loop; other site 1166016009012 ATP binding site [chemical binding]; other site 1166016009013 Q-loop/lid; other site 1166016009014 ABC transporter signature motif; other site 1166016009015 Walker B; other site 1166016009016 D-loop; other site 1166016009017 H-loop/switch region; other site 1166016009018 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1166016009019 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1166016009020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016009021 dimer interface [polypeptide binding]; other site 1166016009022 conserved gate region; other site 1166016009023 putative PBP binding loops; other site 1166016009024 ABC-ATPase subunit interface; other site 1166016009025 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1166016009026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1166016009027 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1166016009028 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1166016009029 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1166016009030 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1166016009031 TOBE domain; Region: TOBE; cl01440 1166016009032 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1166016009033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016009034 Walker A/P-loop; other site 1166016009035 ATP binding site [chemical binding]; other site 1166016009036 Q-loop/lid; other site 1166016009037 ABC transporter signature motif; other site 1166016009038 Walker B; other site 1166016009039 D-loop; other site 1166016009040 H-loop/switch region; other site 1166016009041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016009042 Walker A/P-loop; other site 1166016009043 ATP binding site [chemical binding]; other site 1166016009044 Q-loop/lid; other site 1166016009045 ABC transporter signature motif; other site 1166016009046 Walker B; other site 1166016009047 D-loop; other site 1166016009048 H-loop/switch region; other site 1166016009049 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1166016009050 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1166016009051 NAD binding site [chemical binding]; other site 1166016009052 homodimer interface [polypeptide binding]; other site 1166016009053 active site 1166016009054 substrate binding site [chemical binding]; other site 1166016009055 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1166016009056 active site 1166016009057 catalytic residues [active] 1166016009058 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1166016009059 Outer membrane efflux protein; Region: OEP; pfam02321 1166016009060 Outer membrane efflux protein; Region: OEP; pfam02321 1166016009061 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1166016009062 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016009063 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1166016009064 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1166016009065 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166016009066 catalytic core [active] 1166016009067 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166016009068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016009069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016009070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016009071 dimerization interface [polypeptide binding]; other site 1166016009072 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166016009073 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166016009074 Predicted membrane protein [Function unknown]; Region: COG2259 1166016009075 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1166016009076 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1166016009077 zinc transporter ZitB; Provisional; Region: PRK03557 1166016009078 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1166016009079 quinolinate synthetase; Provisional; Region: PRK09375 1166016009080 hypothetical protein; Provisional; Region: PRK10039 1166016009081 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1166016009082 tol-pal system protein YbgF; Provisional; Region: PRK10803 1166016009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016009084 binding surface 1166016009085 TPR motif; other site 1166016009086 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1166016009087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1166016009088 ligand binding site [chemical binding]; other site 1166016009089 translocation protein TolB; Provisional; Region: tolB; PRK03629 1166016009090 TolB amino-terminal domain; Region: TolB_N; pfam04052 1166016009091 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166016009092 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1166016009093 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1166016009094 TolA C-terminal; Region: TolA; pfam06519 1166016009095 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1166016009096 colicin uptake protein TolR; Provisional; Region: PRK11024 1166016009097 colicin uptake protein TolQ; Provisional; Region: PRK10801 1166016009098 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1166016009099 active site 1166016009100 hypothetical protein; Provisional; Region: PRK10588 1166016009101 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1166016009102 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1166016009103 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1166016009104 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1166016009105 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1166016009106 TPR repeat; Region: TPR_11; pfam13414 1166016009107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1166016009108 TPR motif; other site 1166016009109 binding surface 1166016009110 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1166016009111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1166016009112 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1166016009113 CoA binding domain; Region: CoA_binding; smart00881 1166016009114 CoA-ligase; Region: Ligase_CoA; pfam00549 1166016009115 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1166016009116 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1166016009117 CoA-ligase; Region: Ligase_CoA; pfam00549 1166016009118 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1166016009119 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166016009120 E3 interaction surface; other site 1166016009121 lipoyl attachment site [posttranslational modification]; other site 1166016009122 e3 binding domain; Region: E3_binding; pfam02817 1166016009123 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1166016009124 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1166016009125 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1166016009126 TPP-binding site [chemical binding]; other site 1166016009127 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1166016009128 dimer interface [polypeptide binding]; other site 1166016009129 PYR/PP interface [polypeptide binding]; other site 1166016009130 TPP binding site [chemical binding]; other site 1166016009131 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1166016009132 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1166016009133 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1166016009134 L-aspartate oxidase; Provisional; Region: PRK06175 1166016009135 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1166016009136 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1166016009137 SdhC subunit interface [polypeptide binding]; other site 1166016009138 proximal heme binding site [chemical binding]; other site 1166016009139 cardiolipin binding site; other site 1166016009140 Iron-sulfur protein interface; other site 1166016009141 proximal quinone binding site [chemical binding]; other site 1166016009142 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1166016009143 Iron-sulfur protein interface; other site 1166016009144 proximal quinone binding site [chemical binding]; other site 1166016009145 SdhD (CybS) interface [polypeptide binding]; other site 1166016009146 proximal heme binding site [chemical binding]; other site 1166016009147 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1166016009148 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1166016009149 dimer interface [polypeptide binding]; other site 1166016009150 active site 1166016009151 citrylCoA binding site [chemical binding]; other site 1166016009152 NADH binding [chemical binding]; other site 1166016009153 cationic pore residues; other site 1166016009154 oxalacetate/citrate binding site [chemical binding]; other site 1166016009155 coenzyme A binding site [chemical binding]; other site 1166016009156 catalytic triad [active] 1166016009157 endonuclease VIII; Provisional; Region: PRK10445 1166016009158 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1166016009159 DNA binding site [nucleotide binding] 1166016009160 catalytic residue [active] 1166016009161 H2TH interface [polypeptide binding]; other site 1166016009162 putative catalytic residues [active] 1166016009163 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1166016009164 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1166016009165 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1166016009166 putative substrate binding pocket [chemical binding]; other site 1166016009167 AC domain interface; other site 1166016009168 catalytic triad [active] 1166016009169 AB domain interface; other site 1166016009170 interchain disulfide; other site 1166016009171 LamB/YcsF family protein; Provisional; Region: PRK05406 1166016009172 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1166016009173 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1166016009174 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1166016009175 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1166016009176 metal-binding protein; Provisional; Region: PRK10799 1166016009177 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1166016009178 DNA photolyase; Region: DNA_photolyase; pfam00875 1166016009179 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1166016009180 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1166016009181 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1166016009182 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1166016009183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016009184 active site 1166016009185 dimerization interface [polypeptide binding]; other site 1166016009186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016009187 Predicted membrane protein [Function unknown]; Region: COG2510 1166016009188 phosphoglucomutase; Validated; Region: PRK07564 1166016009189 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1166016009190 active site 1166016009191 substrate binding site [chemical binding]; other site 1166016009192 metal binding site [ion binding]; metal-binding site 1166016009193 replication initiation regulator SeqA; Provisional; Region: PRK11187 1166016009194 acyl-CoA esterase; Provisional; Region: PRK10673 1166016009195 PGAP1-like protein; Region: PGAP1; pfam07819 1166016009196 LexA regulated protein; Provisional; Region: PRK11675 1166016009197 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166016009198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016009199 dimer interface [polypeptide binding]; other site 1166016009200 putative CheW interface [polypeptide binding]; other site 1166016009201 flavodoxin FldA; Validated; Region: PRK09267 1166016009202 ferric uptake regulator; Provisional; Region: fur; PRK09462 1166016009203 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1166016009204 metal binding site 2 [ion binding]; metal-binding site 1166016009205 putative DNA binding helix; other site 1166016009206 metal binding site 1 [ion binding]; metal-binding site 1166016009207 dimer interface [polypeptide binding]; other site 1166016009208 structural Zn2+ binding site [ion binding]; other site 1166016009209 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1166016009210 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166016009211 active site 1166016009212 HIGH motif; other site 1166016009213 nucleotide binding site [chemical binding]; other site 1166016009214 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1166016009215 KMSKS motif; other site 1166016009216 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1166016009217 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016009218 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1166016009219 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016009220 active site turn [active] 1166016009221 phosphorylation site [posttranslational modification] 1166016009222 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1166016009223 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1166016009224 active site 1166016009225 trimer interface [polypeptide binding]; other site 1166016009226 allosteric site; other site 1166016009227 active site lid [active] 1166016009228 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1166016009229 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1166016009230 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1166016009231 active site 1166016009232 dimer interface [polypeptide binding]; other site 1166016009233 MarR family; Region: MarR; pfam01047 1166016009234 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1166016009235 ROK family; Region: ROK; pfam00480 1166016009236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1166016009237 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1166016009238 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1166016009239 active site 1166016009240 dimer interface [polypeptide binding]; other site 1166016009241 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1166016009242 Ligand Binding Site [chemical binding]; other site 1166016009243 Molecular Tunnel; other site 1166016009244 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1166016009245 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1166016009246 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1166016009247 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1166016009248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016009249 FeS/SAM binding site; other site 1166016009250 TRAM domain; Region: TRAM; pfam01938 1166016009251 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1166016009252 PhoH-like protein; Region: PhoH; pfam02562 1166016009253 metal-binding heat shock protein; Provisional; Region: PRK00016 1166016009254 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1166016009255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166016009256 Transporter associated domain; Region: CorC_HlyC; smart01091 1166016009257 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1166016009258 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1166016009259 putative active site [active] 1166016009260 catalytic triad [active] 1166016009261 putative dimer interface [polypeptide binding]; other site 1166016009262 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1166016009263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016009264 substrate binding pocket [chemical binding]; other site 1166016009265 membrane-bound complex binding site; other site 1166016009266 hinge residues; other site 1166016009267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016009268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016009269 dimer interface [polypeptide binding]; other site 1166016009270 conserved gate region; other site 1166016009271 putative PBP binding loops; other site 1166016009272 ABC-ATPase subunit interface; other site 1166016009273 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016009274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016009275 dimer interface [polypeptide binding]; other site 1166016009276 conserved gate region; other site 1166016009277 putative PBP binding loops; other site 1166016009278 ABC-ATPase subunit interface; other site 1166016009279 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016009280 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016009281 Walker A/P-loop; other site 1166016009282 ATP binding site [chemical binding]; other site 1166016009283 Q-loop/lid; other site 1166016009284 ABC transporter signature motif; other site 1166016009285 Walker B; other site 1166016009286 D-loop; other site 1166016009287 H-loop/switch region; other site 1166016009288 hypothetical protein; Provisional; Region: PRK11032 1166016009289 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1166016009290 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1166016009291 HIGH motif; other site 1166016009292 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1166016009293 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166016009294 active site 1166016009295 KMSKS motif; other site 1166016009296 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1166016009297 tRNA binding surface [nucleotide binding]; other site 1166016009298 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1166016009299 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1166016009300 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1166016009301 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1166016009302 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1166016009303 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1166016009304 active site 1166016009305 ribosome-associated protein; Provisional; Region: PRK11538 1166016009306 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1166016009307 penicillin-binding protein 2; Provisional; Region: PRK10795 1166016009308 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1166016009309 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1166016009310 cell wall shape-determining protein; Provisional; Region: PRK10794 1166016009311 rare lipoprotein A; Provisional; Region: PRK10672 1166016009312 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1166016009313 Sporulation related domain; Region: SPOR; pfam05036 1166016009314 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1166016009315 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1166016009316 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1166016009317 hypothetical protein; Provisional; Region: PRK04998 1166016009318 lipoate-protein ligase B; Provisional; Region: PRK14342 1166016009319 lipoyl synthase; Provisional; Region: PRK05481 1166016009320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016009321 FeS/SAM binding site; other site 1166016009322 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 1166016009323 chromosome condensation membrane protein; Provisional; Region: PRK14196 1166016009324 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1166016009325 DNA-binding site [nucleotide binding]; DNA binding site 1166016009326 RNA-binding motif; other site 1166016009327 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1166016009328 aspartate racemase; Region: asp_race; TIGR00035 1166016009329 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1166016009330 ArsC family; Region: ArsC; pfam03960 1166016009331 putative catalytic residues [active] 1166016009332 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1166016009333 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1166016009334 metal binding site [ion binding]; metal-binding site 1166016009335 dimer interface [polypeptide binding]; other site 1166016009336 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1166016009337 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1166016009338 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 1166016009339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016009340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016009341 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1166016009342 putative dimerization interface [polypeptide binding]; other site 1166016009343 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1166016009344 Citrate transporter; Region: CitMHS; pfam03600 1166016009345 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1166016009346 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 1166016009347 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1166016009348 putative acyltransferase; Provisional; Region: PRK05790 1166016009349 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166016009350 dimer interface [polypeptide binding]; other site 1166016009351 active site 1166016009352 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1166016009353 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166016009354 dimer interface [polypeptide binding]; other site 1166016009355 ligand binding site [chemical binding]; other site 1166016009356 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016009357 dimerization interface [polypeptide binding]; other site 1166016009358 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016009359 dimer interface [polypeptide binding]; other site 1166016009360 putative CheW interface [polypeptide binding]; other site 1166016009361 putative hydrolase; Provisional; Region: PRK11460 1166016009362 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1166016009363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1166016009364 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1166016009365 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1166016009366 Helicase; Region: Helicase_RecD; pfam05127 1166016009367 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1166016009368 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1166016009369 Predicted membrane protein [Function unknown]; Region: COG2707 1166016009370 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1166016009371 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1166016009372 ATP binding site [chemical binding]; other site 1166016009373 active site 1166016009374 substrate binding site [chemical binding]; other site 1166016009375 lipoprotein; Provisional; Region: PRK11679 1166016009376 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1166016009377 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1166016009378 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1166016009379 dimer interface [polypeptide binding]; other site 1166016009380 active site 1166016009381 catalytic residue [active] 1166016009382 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1166016009383 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1166016009384 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166016009385 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1166016009386 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1166016009387 catalytic triad [active] 1166016009388 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1166016009389 Peptidase family M48; Region: Peptidase_M48; pfam01435 1166016009390 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1166016009391 ArsC family; Region: ArsC; pfam03960 1166016009392 catalytic residues [active] 1166016009393 DNA replication initiation factor; Provisional; Region: PRK08084 1166016009394 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1166016009395 uracil transporter; Provisional; Region: PRK10720 1166016009396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016009397 active site 1166016009398 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1166016009399 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1166016009400 dimerization interface [polypeptide binding]; other site 1166016009401 putative ATP binding site [chemical binding]; other site 1166016009402 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1166016009403 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1166016009404 active site 1166016009405 substrate binding site [chemical binding]; other site 1166016009406 cosubstrate binding site; other site 1166016009407 catalytic site [active] 1166016009408 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016009409 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1166016009410 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1166016009411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016009412 Coenzyme A binding pocket [chemical binding]; other site 1166016009413 FtsX-like permease family; Region: FtsX; pfam02687 1166016009414 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1166016009415 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166016009416 Walker A/P-loop; other site 1166016009417 ATP binding site [chemical binding]; other site 1166016009418 Q-loop/lid; other site 1166016009419 ABC transporter signature motif; other site 1166016009420 Walker B; other site 1166016009421 D-loop; other site 1166016009422 H-loop/switch region; other site 1166016009423 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1166016009424 active site 1166016009425 oxyanion hole [active] 1166016009426 switch loop; other site 1166016009427 catalytic triad [active] 1166016009428 oxidoreductase; Provisional; Region: PRK08017 1166016009429 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1166016009430 NADP binding site [chemical binding]; other site 1166016009431 active site 1166016009432 steroid binding site; other site 1166016009433 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1166016009434 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1166016009435 hypothetical protein; Provisional; Region: PRK03673 1166016009436 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1166016009437 putative MPT binding site; other site 1166016009438 Competence-damaged protein; Region: CinA; cl00666 1166016009439 tyrosine transporter TyrP; Provisional; Region: PRK15132 1166016009440 aromatic amino acid transport protein; Region: araaP; TIGR00837 1166016009441 YfaZ precursor; Region: YfaZ; pfam07437 1166016009442 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1166016009443 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1166016009444 acyl-activating enzyme (AAE) consensus motif; other site 1166016009445 putative AMP binding site [chemical binding]; other site 1166016009446 putative active site [active] 1166016009447 putative CoA binding site [chemical binding]; other site 1166016009448 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1166016009449 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1166016009450 active site 1166016009451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166016009452 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1166016009453 substrate binding site [chemical binding]; other site 1166016009454 oxyanion hole (OAH) forming residues; other site 1166016009455 trimer interface [polypeptide binding]; other site 1166016009456 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1166016009457 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1166016009458 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1166016009459 dimer interface [polypeptide binding]; other site 1166016009460 tetramer interface [polypeptide binding]; other site 1166016009461 PYR/PP interface [polypeptide binding]; other site 1166016009462 TPP binding site [chemical binding]; other site 1166016009463 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1166016009464 TPP-binding site; other site 1166016009465 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1166016009466 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1166016009467 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1166016009468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016009469 NAD(P) binding site [chemical binding]; other site 1166016009470 active site 1166016009471 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166016009472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016009473 putative DNA binding site [nucleotide binding]; other site 1166016009474 putative Zn2+ binding site [ion binding]; other site 1166016009475 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1166016009476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016009477 ATP binding site [chemical binding]; other site 1166016009478 G-X-G motif; other site 1166016009479 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166016009480 putative binding surface; other site 1166016009481 active site 1166016009482 transcriptional regulator RcsB; Provisional; Region: PRK10840 1166016009483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016009484 active site 1166016009485 phosphorylation site [posttranslational modification] 1166016009486 intermolecular recognition site; other site 1166016009487 dimerization interface [polypeptide binding]; other site 1166016009488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016009489 DNA binding residues [nucleotide binding] 1166016009490 dimerization interface [polypeptide binding]; other site 1166016009491 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1166016009492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016009493 dimer interface [polypeptide binding]; other site 1166016009494 phosphorylation site [posttranslational modification] 1166016009495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016009496 ATP binding site [chemical binding]; other site 1166016009497 Mg2+ binding site [ion binding]; other site 1166016009498 G-X-G motif; other site 1166016009499 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1166016009500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016009501 active site 1166016009502 phosphorylation site [posttranslational modification] 1166016009503 intermolecular recognition site; other site 1166016009504 dimerization interface [polypeptide binding]; other site 1166016009505 DNA gyrase subunit A; Validated; Region: PRK05560 1166016009506 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1166016009507 CAP-like domain; other site 1166016009508 active site 1166016009509 primary dimer interface [polypeptide binding]; other site 1166016009510 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166016009511 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166016009512 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166016009513 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166016009514 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166016009515 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1166016009516 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1166016009517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016009518 S-adenosylmethionine binding site [chemical binding]; other site 1166016009519 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1166016009520 ATP cone domain; Region: ATP-cone; pfam03477 1166016009521 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1166016009522 active site 1166016009523 dimer interface [polypeptide binding]; other site 1166016009524 catalytic residues [active] 1166016009525 effector binding site; other site 1166016009526 R2 peptide binding site; other site 1166016009527 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1166016009528 dimer interface [polypeptide binding]; other site 1166016009529 putative radical transfer pathway; other site 1166016009530 diiron center [ion binding]; other site 1166016009531 tyrosyl radical; other site 1166016009532 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166016009533 catalytic loop [active] 1166016009534 iron binding site [ion binding]; other site 1166016009535 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1166016009536 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1166016009537 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1166016009538 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1166016009539 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1166016009540 DNA binding residues [nucleotide binding] 1166016009541 dimer interface [polypeptide binding]; other site 1166016009542 copper binding site [ion binding]; other site 1166016009543 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166016009544 metal-binding site [ion binding] 1166016009545 copper exporting ATPase; Provisional; Region: copA; PRK10671 1166016009546 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166016009547 metal-binding site [ion binding] 1166016009548 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1166016009549 metal-binding site [ion binding] 1166016009550 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1166016009551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016009552 motif II; other site 1166016009553 TraB family; Region: TraB; cl12050 1166016009554 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1166016009555 putative deacylase active site [active] 1166016009556 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1166016009557 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1166016009558 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1166016009559 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1166016009560 P-loop, Walker A motif; other site 1166016009561 Base recognition motif; other site 1166016009562 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1166016009563 Uncharacterized small protein [Function unknown]; Region: COG2879 1166016009564 carbon starvation protein A; Provisional; Region: PRK15015 1166016009565 Carbon starvation protein CstA; Region: CstA; pfam02554 1166016009566 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1166016009567 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1166016009568 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1166016009569 active site 1166016009570 metal binding site [ion binding]; metal-binding site 1166016009571 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1166016009572 putative cation:proton antiport protein; Provisional; Region: PRK10669 1166016009573 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1166016009574 TrkA-N domain; Region: TrkA_N; pfam02254 1166016009575 ferrochelatase; Reviewed; Region: hemH; PRK00035 1166016009576 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1166016009577 C-terminal domain interface [polypeptide binding]; other site 1166016009578 active site 1166016009579 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1166016009580 active site 1166016009581 N-terminal domain interface [polypeptide binding]; other site 1166016009582 adenylate kinase; Reviewed; Region: adk; PRK00279 1166016009583 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1166016009584 AMP-binding site [chemical binding]; other site 1166016009585 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1166016009586 heat shock protein 90; Provisional; Region: PRK05218 1166016009587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016009588 ATP binding site [chemical binding]; other site 1166016009589 Mg2+ binding site [ion binding]; other site 1166016009590 G-X-G motif; other site 1166016009591 recombination protein RecR; Reviewed; Region: recR; PRK00076 1166016009592 RecR protein; Region: RecR; pfam02132 1166016009593 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1166016009594 putative active site [active] 1166016009595 putative metal-binding site [ion binding]; other site 1166016009596 tetramer interface [polypeptide binding]; other site 1166016009597 hypothetical protein; Validated; Region: PRK00153 1166016009598 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1166016009599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016009600 Walker A motif; other site 1166016009601 ATP binding site [chemical binding]; other site 1166016009602 Walker B motif; other site 1166016009603 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1166016009604 arginine finger; other site 1166016009605 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1166016009606 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1166016009607 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1166016009608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016009609 active site 1166016009610 hypothetical protein; Provisional; Region: PRK10527 1166016009611 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 1166016009612 hypothetical protein; Provisional; Region: PRK11038 1166016009613 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1166016009614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016009615 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1166016009616 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1166016009617 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016009618 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016009619 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1166016009620 Protein export membrane protein; Region: SecD_SecF; cl14618 1166016009621 Protein export membrane protein; Region: SecD_SecF; cl14618 1166016009622 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1166016009623 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1166016009624 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1166016009625 gene expression modulator; Provisional; Region: PRK10945 1166016009626 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1166016009627 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1166016009628 DNA binding site [nucleotide binding] 1166016009629 active site 1166016009630 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; pfam09619 1166016009631 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1166016009632 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1166016009633 active site 1166016009634 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1166016009635 catalytic triad [active] 1166016009636 dimer interface [polypeptide binding]; other site 1166016009637 ammonium transporter; Provisional; Region: PRK10666 1166016009638 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1166016009639 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1166016009640 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1166016009641 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016009642 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1166016009643 Walker A/P-loop; other site 1166016009644 ATP binding site [chemical binding]; other site 1166016009645 Q-loop/lid; other site 1166016009646 ABC transporter signature motif; other site 1166016009647 Walker B; other site 1166016009648 D-loop; other site 1166016009649 H-loop/switch region; other site 1166016009650 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1166016009651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016009652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016009653 Walker A/P-loop; other site 1166016009654 ATP binding site [chemical binding]; other site 1166016009655 Q-loop/lid; other site 1166016009656 ABC transporter signature motif; other site 1166016009657 Walker B; other site 1166016009658 D-loop; other site 1166016009659 H-loop/switch region; other site 1166016009660 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1166016009661 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1166016009662 putative DNA binding site [nucleotide binding]; other site 1166016009663 putative Zn2+ binding site [ion binding]; other site 1166016009664 AsnC family; Region: AsnC_trans_reg; pfam01037 1166016009665 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1166016009666 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1166016009667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016009668 catalytic residue [active] 1166016009669 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1166016009670 Ligand Binding Site [chemical binding]; other site 1166016009671 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1166016009672 active site 1166016009673 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1166016009674 periplasmic folding chaperone; Provisional; Region: PRK10788 1166016009675 SurA N-terminal domain; Region: SurA_N_3; cl07813 1166016009676 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1166016009677 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1166016009678 IHF dimer interface [polypeptide binding]; other site 1166016009679 IHF - DNA interface [nucleotide binding]; other site 1166016009680 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1166016009681 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1166016009682 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1166016009683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016009684 Walker A motif; other site 1166016009685 ATP binding site [chemical binding]; other site 1166016009686 Walker B motif; other site 1166016009687 arginine finger; other site 1166016009688 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1166016009689 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1166016009690 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1166016009691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016009692 Walker A motif; other site 1166016009693 ATP binding site [chemical binding]; other site 1166016009694 Walker B motif; other site 1166016009695 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1166016009696 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1166016009697 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1166016009698 oligomer interface [polypeptide binding]; other site 1166016009699 active site residues [active] 1166016009700 trigger factor; Provisional; Region: tig; PRK01490 1166016009701 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166016009702 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1166016009703 transcriptional regulator BolA; Provisional; Region: PRK11628 1166016009704 hypothetical protein; Provisional; Region: PRK11627 1166016009705 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1166016009706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016009707 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1166016009708 putative substrate translocation pore; other site 1166016009709 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1166016009710 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1166016009711 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1166016009712 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1166016009713 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1166016009714 D-pathway; other site 1166016009715 Putative ubiquinol binding site [chemical binding]; other site 1166016009716 Low-spin heme (heme b) binding site [chemical binding]; other site 1166016009717 Putative water exit pathway; other site 1166016009718 Binuclear center (heme o3/CuB) [ion binding]; other site 1166016009719 K-pathway; other site 1166016009720 Putative proton exit pathway; other site 1166016009721 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1166016009722 Subunit I/III interface [polypeptide binding]; other site 1166016009723 Subunit III/IV interface [polypeptide binding]; other site 1166016009724 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1166016009725 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1166016009726 UbiA prenyltransferase family; Region: UbiA; pfam01040 1166016009727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016009728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016009729 putative substrate translocation pore; other site 1166016009730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1166016009731 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1166016009732 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1166016009733 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1166016009734 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1166016009735 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1166016009736 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1166016009737 conserved cys residue [active] 1166016009738 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1166016009739 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1166016009740 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1166016009741 Ligand Binding Site [chemical binding]; other site 1166016009742 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1166016009743 active site residue [active] 1166016009744 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1166016009745 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1166016009746 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1166016009747 substrate binding pocket [chemical binding]; other site 1166016009748 chain length determination region; other site 1166016009749 substrate-Mg2+ binding site; other site 1166016009750 catalytic residues [active] 1166016009751 aspartate-rich region 1; other site 1166016009752 active site lid residues [active] 1166016009753 aspartate-rich region 2; other site 1166016009754 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1166016009755 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1166016009756 TPP-binding site; other site 1166016009757 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166016009758 PYR/PP interface [polypeptide binding]; other site 1166016009759 dimer interface [polypeptide binding]; other site 1166016009760 TPP binding site [chemical binding]; other site 1166016009761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166016009762 thiamine monophosphate kinase; Provisional; Region: PRK05731 1166016009763 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1166016009764 ATP binding site [chemical binding]; other site 1166016009765 dimerization interface [polypeptide binding]; other site 1166016009766 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1166016009767 putative RNA binding site [nucleotide binding]; other site 1166016009768 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1166016009769 homopentamer interface [polypeptide binding]; other site 1166016009770 active site 1166016009771 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1166016009772 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1166016009773 catalytic motif [active] 1166016009774 Zn binding site [ion binding]; other site 1166016009775 RibD C-terminal domain; Region: RibD_C; cl17279 1166016009776 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1166016009777 ATP cone domain; Region: ATP-cone; pfam03477 1166016009778 hypothetical protein; Provisional; Region: PRK11530 1166016009779 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1166016009780 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1166016009781 Protein export membrane protein; Region: SecD_SecF; pfam02355 1166016009782 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1166016009783 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1166016009784 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1166016009785 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1166016009786 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1166016009787 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1166016009788 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1166016009789 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1166016009790 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1166016009791 Protein of unknown function, DUF479; Region: DUF479; cl01203 1166016009792 peroxidase; Provisional; Region: PRK15000 1166016009793 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1166016009794 dimer interface [polypeptide binding]; other site 1166016009795 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1166016009796 catalytic triad [active] 1166016009797 peroxidatic and resolving cysteines [active] 1166016009798 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1166016009799 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166016009800 putative proline-specific permease; Provisional; Region: proY; PRK10580 1166016009801 Spore germination protein; Region: Spore_permease; cl17796 1166016009802 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1166016009803 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1166016009804 substrate binding site [chemical binding]; other site 1166016009805 THF binding site; other site 1166016009806 zinc-binding site [ion binding]; other site 1166016009807 PBP superfamily domain; Region: PBP_like_2; cl17296 1166016009808 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1166016009809 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1166016009810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016009811 putative active site [active] 1166016009812 heme pocket [chemical binding]; other site 1166016009813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016009814 dimer interface [polypeptide binding]; other site 1166016009815 phosphorylation site [posttranslational modification] 1166016009816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016009817 ATP binding site [chemical binding]; other site 1166016009818 Mg2+ binding site [ion binding]; other site 1166016009819 G-X-G motif; other site 1166016009820 transcriptional regulator PhoB; Provisional; Region: PRK10161 1166016009821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016009822 active site 1166016009823 phosphorylation site [posttranslational modification] 1166016009824 intermolecular recognition site; other site 1166016009825 dimerization interface [polypeptide binding]; other site 1166016009826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016009827 DNA binding site [nucleotide binding] 1166016009828 exonuclease subunit SbcD; Provisional; Region: PRK10966 1166016009829 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1166016009830 active site 1166016009831 metal binding site [ion binding]; metal-binding site 1166016009832 DNA binding site [nucleotide binding] 1166016009833 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1166016009834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016009835 AAA domain; Region: AAA_23; pfam13476 1166016009836 Walker A/P-loop; other site 1166016009837 ATP binding site [chemical binding]; other site 1166016009838 Q-loop/lid; other site 1166016009839 exonuclease subunit SbcC; Provisional; Region: PRK10246 1166016009840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016009841 Q-loop/lid; other site 1166016009842 ABC transporter signature motif; other site 1166016009843 Walker B; other site 1166016009844 D-loop; other site 1166016009845 H-loop/switch region; other site 1166016009846 fructokinase; Reviewed; Region: PRK09557 1166016009847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166016009848 nucleotide binding site [chemical binding]; other site 1166016009849 Acetokinase family; Region: Acetate_kinase; cl17229 1166016009850 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1166016009851 Cache domain; Region: Cache_1; pfam02743 1166016009852 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016009853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016009854 dimerization interface [polypeptide binding]; other site 1166016009855 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016009856 dimer interface [polypeptide binding]; other site 1166016009857 putative CheW interface [polypeptide binding]; other site 1166016009858 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1166016009859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016009860 DNA-binding site [nucleotide binding]; DNA binding site 1166016009861 UTRA domain; Region: UTRA; pfam07702 1166016009862 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016009863 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1166016009864 substrate binding site [chemical binding]; other site 1166016009865 ATP binding site [chemical binding]; other site 1166016009866 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1166016009867 nucleoside transporter; Region: 2A0110; TIGR00889 1166016009868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016009869 putative substrate translocation pore; other site 1166016009870 hypothetical protein; Provisional; Region: PRK10579 1166016009871 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1166016009872 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1166016009873 ADP binding site [chemical binding]; other site 1166016009874 magnesium binding site [ion binding]; other site 1166016009875 putative shikimate binding site; other site 1166016009876 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1166016009877 active site 1166016009878 homodimer interface [polypeptide binding]; other site 1166016009879 homotetramer interface [polypeptide binding]; other site 1166016009880 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1166016009881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016009882 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1166016009883 Walker A/P-loop; other site 1166016009884 ATP binding site [chemical binding]; other site 1166016009885 Q-loop/lid; other site 1166016009886 ABC transporter signature motif; other site 1166016009887 Walker B; other site 1166016009888 D-loop; other site 1166016009889 H-loop/switch region; other site 1166016009890 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009891 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009892 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009893 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009894 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009895 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009896 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009897 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009898 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009899 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009900 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009901 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009902 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009903 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009904 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009905 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009906 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009907 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009908 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009909 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009910 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009911 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009912 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009913 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009914 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009915 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009916 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009917 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009918 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009919 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1166016009920 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1166016009921 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1166016009922 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1166016009923 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1166016009924 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1166016009925 Walker A/P-loop; other site 1166016009926 ATP binding site [chemical binding]; other site 1166016009927 Q-loop/lid; other site 1166016009928 ABC transporter signature motif; other site 1166016009929 Walker B; other site 1166016009930 D-loop; other site 1166016009931 H-loop/switch region; other site 1166016009932 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1166016009933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016009934 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016009935 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1166016009936 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1166016009937 Pectate lyase; Region: Pectate_lyase; pfam03211 1166016009938 mannonate dehydratase; Provisional; Region: PRK03906 1166016009939 mannonate dehydratase; Region: uxuA; TIGR00695 1166016009940 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1166016009941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016009942 DNA-binding site [nucleotide binding]; DNA binding site 1166016009943 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166016009944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166016009945 Esterase/lipase [General function prediction only]; Region: COG1647 1166016009946 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1166016009947 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1166016009948 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1166016009949 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016009950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016009951 metal binding site [ion binding]; metal-binding site 1166016009952 active site 1166016009953 I-site; other site 1166016009954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016009955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016009956 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1166016009957 putative dimerization interface [polypeptide binding]; other site 1166016009958 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166016009959 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1166016009960 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016009961 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016009962 catalytic residue [active] 1166016009963 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1166016009964 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1166016009965 PhnA protein; Region: PhnA; pfam03831 1166016009966 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1166016009967 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166016009968 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016009969 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1166016009970 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1166016009971 MutS domain I; Region: MutS_I; pfam01624 1166016009972 MutS domain II; Region: MutS_II; pfam05188 1166016009973 MutS domain III; Region: MutS_III; pfam05192 1166016009974 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1166016009975 Walker A/P-loop; other site 1166016009976 ATP binding site [chemical binding]; other site 1166016009977 Q-loop/lid; other site 1166016009978 ABC transporter signature motif; other site 1166016009979 Walker B; other site 1166016009980 D-loop; other site 1166016009981 H-loop/switch region; other site 1166016009982 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1166016009983 NlpE N-terminal domain; Region: NlpE; pfam04170 1166016009984 YaeQ protein; Region: YaeQ; pfam07152 1166016009985 hypothetical protein; Provisional; Region: PRK04964 1166016009986 Rho-binding antiterminator; Provisional; Region: PRK11625 1166016009987 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1166016009988 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1166016009989 Ligand Binding Site [chemical binding]; other site 1166016009990 TilS substrate binding domain; Region: TilS; pfam09179 1166016009991 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1166016009992 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1166016009993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166016009994 putative metal binding site [ion binding]; other site 1166016009995 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1166016009996 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1166016009997 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1166016009998 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1166016009999 putative active site [active] 1166016010000 putative PHP Thumb interface [polypeptide binding]; other site 1166016010001 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1166016010002 generic binding surface II; other site 1166016010003 generic binding surface I; other site 1166016010004 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1166016010005 RNA/DNA hybrid binding site [nucleotide binding]; other site 1166016010006 active site 1166016010007 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1166016010008 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1166016010009 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1166016010010 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1166016010011 active site 1166016010012 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1166016010013 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1166016010014 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1166016010015 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1166016010016 trimer interface [polypeptide binding]; other site 1166016010017 active site 1166016010018 UDP-GlcNAc binding site [chemical binding]; other site 1166016010019 lipid binding site [chemical binding]; lipid-binding site 1166016010020 periplasmic chaperone; Provisional; Region: PRK10780 1166016010021 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1166016010022 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1166016010023 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166016010024 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166016010025 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166016010026 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166016010027 Surface antigen; Region: Bac_surface_Ag; pfam01103 1166016010028 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1166016010029 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1166016010030 active site 1166016010031 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1166016010032 protein binding site [polypeptide binding]; other site 1166016010033 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1166016010034 protein binding site [polypeptide binding]; other site 1166016010035 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1166016010036 putative substrate binding region [chemical binding]; other site 1166016010037 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1166016010038 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1166016010039 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1166016010040 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1166016010041 catalytic residue [active] 1166016010042 putative FPP diphosphate binding site; other site 1166016010043 putative FPP binding hydrophobic cleft; other site 1166016010044 dimer interface [polypeptide binding]; other site 1166016010045 putative IPP diphosphate binding site; other site 1166016010046 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1166016010047 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1166016010048 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1166016010049 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1166016010050 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1166016010051 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1166016010052 hinge region; other site 1166016010053 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1166016010054 putative nucleotide binding site [chemical binding]; other site 1166016010055 uridine monophosphate binding site [chemical binding]; other site 1166016010056 homohexameric interface [polypeptide binding]; other site 1166016010057 elongation factor Ts; Provisional; Region: tsf; PRK09377 1166016010058 UBA/TS-N domain; Region: UBA; pfam00627 1166016010059 Elongation factor TS; Region: EF_TS; pfam00889 1166016010060 Elongation factor TS; Region: EF_TS; pfam00889 1166016010061 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1166016010062 rRNA interaction site [nucleotide binding]; other site 1166016010063 S8 interaction site; other site 1166016010064 putative laminin-1 binding site; other site 1166016010065 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1166016010066 active site 1166016010067 PII uridylyl-transferase; Provisional; Region: PRK05007 1166016010068 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1166016010069 metal binding triad; other site 1166016010070 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1166016010071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1166016010072 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1166016010073 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1166016010074 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1166016010075 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1166016010076 trimer interface [polypeptide binding]; other site 1166016010077 active site 1166016010078 substrate binding site [chemical binding]; other site 1166016010079 CoA binding site [chemical binding]; other site 1166016010080 hypothetical protein; Provisional; Region: PRK13677 1166016010081 flavodoxin; Provisional; Region: PRK08105 1166016010082 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1166016010083 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1166016010084 probable active site [active] 1166016010085 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1166016010086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166016010087 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1166016010088 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1166016010089 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1166016010090 active site 1166016010091 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1166016010092 SecY interacting protein Syd; Provisional; Region: PRK04968 1166016010093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1166016010094 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1166016010095 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1166016010096 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1166016010097 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1166016010098 flap endonuclease-like protein; Provisional; Region: PRK09482 1166016010099 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1166016010100 active site 1166016010101 metal binding site 1 [ion binding]; metal-binding site 1166016010102 putative 5' ssDNA interaction site; other site 1166016010103 metal binding site 3; metal-binding site 1166016010104 metal binding site 2 [ion binding]; metal-binding site 1166016010105 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1166016010106 putative DNA binding site [nucleotide binding]; other site 1166016010107 putative metal binding site [ion binding]; other site 1166016010108 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1166016010109 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1166016010110 hypothetical protein; Provisional; Region: PRK10873 1166016010111 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1166016010112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016010113 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1166016010114 dimerization interface [polypeptide binding]; other site 1166016010115 substrate binding pocket [chemical binding]; other site 1166016010116 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1166016010117 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1166016010118 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1166016010119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016010120 catalytic residue [active] 1166016010121 Fe-S metabolism associated domain; Region: SufE; cl00951 1166016010122 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1166016010123 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1166016010124 putative ATP binding site [chemical binding]; other site 1166016010125 putative substrate interface [chemical binding]; other site 1166016010126 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1166016010127 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1166016010128 molybdopterin cofactor binding site [chemical binding]; other site 1166016010129 substrate binding site [chemical binding]; other site 1166016010130 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1166016010131 molybdopterin cofactor binding site; other site 1166016010132 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1166016010133 MltA specific insert domain; Region: MltA; smart00925 1166016010134 3D domain; Region: 3D; pfam06725 1166016010135 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1166016010136 AMIN domain; Region: AMIN; pfam11741 1166016010137 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1166016010138 active site 1166016010139 metal binding site [ion binding]; metal-binding site 1166016010140 N-acetylglutamate synthase; Validated; Region: PRK05279 1166016010141 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1166016010142 putative feedback inhibition sensing region; other site 1166016010143 putative nucleotide binding site [chemical binding]; other site 1166016010144 putative substrate binding site [chemical binding]; other site 1166016010145 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 1166016010146 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1166016010147 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1166016010148 active site pocket [active] 1166016010149 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016010150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016010151 DNA binding site [nucleotide binding] 1166016010152 domain linker motif; other site 1166016010153 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1166016010154 putative dimerization interface [polypeptide binding]; other site 1166016010155 putative ligand binding site [chemical binding]; other site 1166016010156 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1166016010157 AAA domain; Region: AAA_30; pfam13604 1166016010158 Family description; Region: UvrD_C_2; pfam13538 1166016010159 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1166016010160 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1166016010161 protease3; Provisional; Region: PRK15101 1166016010162 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1166016010163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166016010164 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1166016010165 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1166016010166 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1166016010167 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1166016010168 Protein of unknown function (DUF2509); Region: DUF2509; pfam10713 1166016010169 hypothetical protein; Provisional; Region: PRK10557 1166016010170 hypothetical protein; Provisional; Region: PRK10506 1166016010171 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1166016010172 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1166016010173 dimerization interface [polypeptide binding]; other site 1166016010174 active site 1166016010175 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1166016010176 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1166016010177 GAF domain; Region: GAF; pfam01590 1166016010178 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1166016010179 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1166016010180 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1166016010181 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1166016010182 putative active site [active] 1166016010183 Ap4A binding site [chemical binding]; other site 1166016010184 nudix motif; other site 1166016010185 putative metal binding site [ion binding]; other site 1166016010186 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1166016010187 putative DNA-binding cleft [nucleotide binding]; other site 1166016010188 putative DNA clevage site; other site 1166016010189 molecular lever; other site 1166016010190 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1166016010191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1166016010192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1166016010193 active site 1166016010194 catalytic tetrad [active] 1166016010195 hypothetical protein; Provisional; Region: PRK10626 1166016010196 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1166016010197 hypothetical protein; Provisional; Region: PRK11702 1166016010198 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1166016010199 adenine DNA glycosylase; Provisional; Region: PRK10880 1166016010200 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1166016010201 minor groove reading motif; other site 1166016010202 helix-hairpin-helix signature motif; other site 1166016010203 substrate binding pocket [chemical binding]; other site 1166016010204 active site 1166016010205 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1166016010206 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1166016010207 DNA binding and oxoG recognition site [nucleotide binding] 1166016010208 oxidative damage protection protein; Provisional; Region: PRK05408 1166016010209 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1166016010210 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1166016010211 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016010212 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016010213 catalytic residue [active] 1166016010214 Helix-turn-helix domain; Region: HTH_18; pfam12833 1166016010215 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1166016010216 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016010217 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1166016010218 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1166016010219 hypothetical protein; Provisional; Region: PRK02399 1166016010220 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1166016010221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016010222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016010223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016010224 L-asparagine permease; Provisional; Region: PRK15049 1166016010225 ornithine decarboxylase; Provisional; Region: PRK13578 1166016010226 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1166016010227 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1166016010228 homodimer interface [polypeptide binding]; other site 1166016010229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016010230 catalytic residue [active] 1166016010231 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1166016010232 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1166016010233 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1166016010234 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1166016010235 active site 1166016010236 catalytic residues [active] 1166016010237 DNA binding site [nucleotide binding] 1166016010238 Int/Topo IB signature motif; other site 1166016010239 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1166016010240 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1166016010241 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1166016010242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1166016010243 MULE transposase domain; Region: MULE; pfam10551 1166016010244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1166016010245 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1166016010246 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1166016010247 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1166016010248 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1166016010249 hypothetical protein; Reviewed; Region: PRK00024 1166016010250 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1166016010251 MPN+ (JAMM) motif; other site 1166016010252 Zinc-binding site [ion binding]; other site 1166016010253 Antirestriction protein; Region: Antirestrict; pfam03230 1166016010254 Protein of unknown function (DUF983); Region: DUF983; cl02211 1166016010255 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1166016010256 Integrase; Region: Integrase_1; pfam12835 1166016010257 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1166016010258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016010259 Coenzyme A binding pocket [chemical binding]; other site 1166016010260 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1166016010261 ArsC family; Region: ArsC; pfam03960 1166016010262 catalytic residues [active] 1166016010263 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1166016010264 putative transposase OrfB; Reviewed; Region: PHA02517 1166016010265 HTH-like domain; Region: HTH_21; pfam13276 1166016010266 Integrase core domain; Region: rve; pfam00665 1166016010267 Integrase core domain; Region: rve_3; pfam13683 1166016010268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1166016010269 Transposase; Region: HTH_Tnp_1; pfam01527 1166016010270 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1166016010271 HTH-like domain; Region: HTH_21; pfam13276 1166016010272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016010273 Integrase core domain; Region: rve; pfam00665 1166016010274 Integrase core domain; Region: rve_3; pfam13683 1166016010275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016010276 Transposase; Region: HTH_Tnp_1; pfam01527 1166016010277 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1166016010278 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016010279 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166016010280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016010281 putative substrate translocation pore; other site 1166016010282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016010283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016010284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1166016010285 putative effector binding pocket; other site 1166016010286 putative dimerization interface [polypeptide binding]; other site 1166016010287 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1166016010288 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1166016010289 DHH family; Region: DHH; pfam01368 1166016010290 DHHA2 domain; Region: DHHA2; pfam02833 1166016010291 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1166016010292 enolase; Provisional; Region: eno; PRK00077 1166016010293 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1166016010294 dimer interface [polypeptide binding]; other site 1166016010295 metal binding site [ion binding]; metal-binding site 1166016010296 substrate binding pocket [chemical binding]; other site 1166016010297 chromosome condensation membrane protein; Provisional; Region: PRK14196 1166016010298 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1166016010299 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166016010300 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1166016010301 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1166016010302 active site 1166016010303 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1166016010304 ArsC family; Region: ArsC; pfam03960 1166016010305 catalytic residues [active] 1166016010306 arsenical pump membrane protein; Provisional; Region: PRK15445 1166016010307 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1166016010308 transmembrane helices; other site 1166016010309 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1166016010310 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1166016010311 P loop; other site 1166016010312 Nucleotide binding site [chemical binding]; other site 1166016010313 DTAP/Switch II; other site 1166016010314 Switch I; other site 1166016010315 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1166016010316 DTAP/Switch II; other site 1166016010317 Switch I; other site 1166016010318 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1166016010319 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1166016010320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016010321 dimerization interface [polypeptide binding]; other site 1166016010322 putative DNA binding site [nucleotide binding]; other site 1166016010323 putative Zn2+ binding site [ion binding]; other site 1166016010324 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 1166016010325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016010326 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016010327 DNA binding residues [nucleotide binding] 1166016010328 Predicted permease; Region: DUF318; cl17795 1166016010329 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1166016010330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166016010331 Ligand Binding Site [chemical binding]; other site 1166016010332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166016010333 Ligand Binding Site [chemical binding]; other site 1166016010334 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1166016010335 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1166016010336 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1166016010337 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1166016010338 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1166016010339 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1166016010340 P loop; other site 1166016010341 Nucleotide binding site [chemical binding]; other site 1166016010342 Switch I; other site 1166016010343 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1166016010344 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 1166016010345 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1166016010346 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1166016010347 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1166016010348 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1166016010349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1166016010350 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1166016010351 classical (c) SDRs; Region: SDR_c; cd05233 1166016010352 NAD(P) binding site [chemical binding]; other site 1166016010353 active site 1166016010354 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1166016010355 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1166016010356 catalytic residues [active] 1166016010357 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1166016010358 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1166016010359 FMN binding site [chemical binding]; other site 1166016010360 active site 1166016010361 substrate binding site [chemical binding]; other site 1166016010362 catalytic residue [active] 1166016010363 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1166016010364 catalytic residues [active] 1166016010365 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1166016010366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1166016010367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016010368 OsmC-like protein; Region: OsmC; pfam02566 1166016010369 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1166016010370 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1166016010371 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1166016010372 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1166016010373 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1166016010374 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1166016010375 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1166016010376 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 1166016010377 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1166016010378 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1166016010379 PAAR motif; Region: PAAR_motif; pfam05488 1166016010380 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016010381 RHS Repeat; Region: RHS_repeat; pfam05593 1166016010382 RHS Repeat; Region: RHS_repeat; pfam05593 1166016010383 RHS Repeat; Region: RHS_repeat; pfam05593 1166016010384 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166016010385 RHS Repeat; Region: RHS_repeat; pfam05593 1166016010386 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016010387 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1166016010388 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016010389 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016010390 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016010391 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1166016010392 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016010393 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1166016010394 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1166016010395 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1166016010396 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1166016010397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016010398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016010399 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1166016010400 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1166016010401 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016010402 active site 1166016010403 DNA binding site [nucleotide binding] 1166016010404 Int/Topo IB signature motif; other site 1166016010405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016010406 Phage Tail Collar Domain; Region: Collar; pfam07484 1166016010407 Phage Tail Collar Domain; Region: Collar; pfam07484 1166016010408 Phage Tail Collar Domain; Region: Collar; pfam07484 1166016010409 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1166016010410 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1166016010411 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016010412 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016010413 catalytic residue [active] 1166016010414 PilS N terminal; Region: PilS; pfam08805 1166016010415 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1166016010416 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016010417 Type II/IV secretion system protein; Region: T2SE; pfam00437 1166016010418 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1166016010419 Walker A motif; other site 1166016010420 ATP binding site [chemical binding]; other site 1166016010421 Walker B motif; other site 1166016010422 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1166016010423 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1166016010424 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1166016010425 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016010426 PilM; Region: PilM; pfam07419 1166016010427 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1166016010428 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1166016010429 Domain of unknown function DUF29; Region: DUF29; pfam01724 1166016010430 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1166016010431 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1166016010432 dimer interface [polypeptide binding]; other site 1166016010433 ssDNA binding site [nucleotide binding]; other site 1166016010434 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166016010435 putative single-stranded DNA-binding protein; Region: PHA01740 1166016010436 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1166016010437 DNA topoisomerase III; Provisional; Region: PRK07726 1166016010438 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1166016010439 active site 1166016010440 putative interdomain interaction site [polypeptide binding]; other site 1166016010441 putative metal-binding site [ion binding]; other site 1166016010442 putative nucleotide binding site [chemical binding]; other site 1166016010443 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1166016010444 domain I; other site 1166016010445 DNA binding groove [nucleotide binding] 1166016010446 phosphate binding site [ion binding]; other site 1166016010447 domain II; other site 1166016010448 domain III; other site 1166016010449 nucleotide binding site [chemical binding]; other site 1166016010450 catalytic site [active] 1166016010451 domain IV; other site 1166016010452 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016010453 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 1166016010454 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1166016010455 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1166016010456 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1166016010457 ParB-like nuclease domain; Region: ParBc; pfam02195 1166016010458 replicative DNA helicase; Region: DnaB; TIGR00665 1166016010459 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1166016010460 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1166016010461 Walker A motif; other site 1166016010462 ATP binding site [chemical binding]; other site 1166016010463 Walker B motif; other site 1166016010464 DNA binding loops [nucleotide binding] 1166016010465 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1166016010466 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1166016010467 catalytic residue [active] 1166016010468 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1166016010469 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1166016010470 P-loop; other site 1166016010471 Magnesium ion binding site [ion binding]; other site 1166016010472 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1166016010473 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016010474 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1166016010475 Prophage antirepressor [Transcription]; Region: COG3617 1166016010476 BRO family, N-terminal domain; Region: Bro-N; smart01040 1166016010477 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1166016010478 integrase; Provisional; Region: PRK09692 1166016010479 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016010480 active site 1166016010481 Int/Topo IB signature motif; other site 1166016010482 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1166016010483 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1166016010484 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1166016010485 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1166016010486 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1166016010487 putative catalytic cysteine [active] 1166016010488 gamma-glutamyl kinase; Provisional; Region: PRK05429 1166016010489 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1166016010490 nucleotide binding site [chemical binding]; other site 1166016010491 homotetrameric interface [polypeptide binding]; other site 1166016010492 putative phosphate binding site [ion binding]; other site 1166016010493 putative allosteric binding site; other site 1166016010494 PUA domain; Region: PUA; pfam01472 1166016010495 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1166016010496 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016010497 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016010498 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016010499 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1166016010500 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016010501 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016010502 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016010503 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016010504 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016010505 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1166016010506 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1166016010507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016010508 active site 1166016010509 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1166016010510 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1166016010511 metal binding site [ion binding]; metal-binding site 1166016010512 dimer interface [polypeptide binding]; other site 1166016010513 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1166016010514 active site 1166016010515 DNA polymerase IV; Validated; Region: PRK02406 1166016010516 DNA binding site [nucleotide binding] 1166016010517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1166016010518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016010519 salt bridge; other site 1166016010520 non-specific DNA binding site [nucleotide binding]; other site 1166016010521 sequence-specific DNA binding site [nucleotide binding]; other site 1166016010522 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1166016010523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016010524 S-adenosylmethionine binding site [chemical binding]; other site 1166016010525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1166016010526 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1166016010527 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1166016010528 putative active site [active] 1166016010529 putative dimer interface [polypeptide binding]; other site 1166016010530 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1166016010531 dimer interface [polypeptide binding]; other site 1166016010532 active site 1166016010533 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1166016010534 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1166016010535 active site 1166016010536 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1166016010537 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1166016010538 active site 1166016010539 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1166016010540 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1166016010541 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1166016010542 PAAR motif; Region: PAAR_motif; pfam05488 1166016010543 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1166016010544 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016010545 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016010546 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1166016010547 Cupin domain; Region: Cupin_2; cl17218 1166016010548 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1166016010549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1166016010550 motif II; other site 1166016010551 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1166016010552 intersubunit interface [polypeptide binding]; other site 1166016010553 active site 1166016010554 Zn2+ binding site [ion binding]; other site 1166016010555 methionine aminotransferase; Validated; Region: PRK09082 1166016010556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016010557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016010558 homodimer interface [polypeptide binding]; other site 1166016010559 catalytic residue [active] 1166016010560 C-N hydrolase family amidase; Provisional; Region: PRK10438 1166016010561 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1166016010562 putative active site [active] 1166016010563 catalytic triad [active] 1166016010564 dimer interface [polypeptide binding]; other site 1166016010565 multimer interface [polypeptide binding]; other site 1166016010566 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1166016010567 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1166016010568 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1166016010569 dimer interface [polypeptide binding]; other site 1166016010570 active site 1166016010571 glycine loop; other site 1166016010572 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1166016010573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016010574 substrate binding pocket [chemical binding]; other site 1166016010575 membrane-bound complex binding site; other site 1166016010576 hinge residues; other site 1166016010577 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016010578 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1166016010579 inhibitor-cofactor binding pocket; inhibition site 1166016010580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016010581 catalytic residue [active] 1166016010582 allantoate amidohydrolase; Reviewed; Region: PRK09290 1166016010583 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1166016010584 active site 1166016010585 metal binding site [ion binding]; metal-binding site 1166016010586 dimer interface [polypeptide binding]; other site 1166016010587 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1166016010588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016010589 catalytic residue [active] 1166016010590 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016010591 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016010592 Walker A/P-loop; other site 1166016010593 ATP binding site [chemical binding]; other site 1166016010594 Q-loop/lid; other site 1166016010595 ABC transporter signature motif; other site 1166016010596 Walker B; other site 1166016010597 D-loop; other site 1166016010598 H-loop/switch region; other site 1166016010599 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1166016010600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016010601 ABC-ATPase subunit interface; other site 1166016010602 putative PBP binding loops; other site 1166016010603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016010604 dimer interface [polypeptide binding]; other site 1166016010605 conserved gate region; other site 1166016010606 putative PBP binding loops; other site 1166016010607 ABC-ATPase subunit interface; other site 1166016010608 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016010609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016010610 substrate binding pocket [chemical binding]; other site 1166016010611 membrane-bound complex binding site; other site 1166016010612 hinge residues; other site 1166016010613 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1166016010614 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1166016010615 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1166016010616 putative active site [active] 1166016010617 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1166016010618 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1166016010619 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1166016010620 amidase; Provisional; Region: PRK09201 1166016010621 Amidase; Region: Amidase; cl11426 1166016010622 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1166016010623 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1166016010624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1166016010625 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1166016010626 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1166016010627 Walker A/P-loop; other site 1166016010628 ATP binding site [chemical binding]; other site 1166016010629 Q-loop/lid; other site 1166016010630 ABC transporter signature motif; other site 1166016010631 Walker B; other site 1166016010632 D-loop; other site 1166016010633 H-loop/switch region; other site 1166016010634 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1166016010635 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1166016010636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016010637 dimer interface [polypeptide binding]; other site 1166016010638 conserved gate region; other site 1166016010639 putative PBP binding loops; other site 1166016010640 ABC-ATPase subunit interface; other site 1166016010641 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1166016010642 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1166016010643 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1166016010644 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1166016010645 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1166016010646 CGNR zinc finger; Region: zf-CGNR; pfam11706 1166016010647 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1166016010648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016010649 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1166016010650 putative L-valine exporter; Provisional; Region: PRK10408 1166016010651 transcriptional repressor MprA; Provisional; Region: PRK10870 1166016010652 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1166016010653 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1166016010654 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1166016010655 HlyD family secretion protein; Region: HlyD_3; pfam13437 1166016010656 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1166016010657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016010658 putative substrate translocation pore; other site 1166016010659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016010660 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1166016010661 putative methyltransferase; Provisional; Region: PRK10864 1166016010662 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1166016010663 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166016010664 thioredoxin 2; Provisional; Region: PRK10996 1166016010665 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1166016010666 catalytic residues [active] 1166016010667 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1166016010668 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1166016010669 CoA binding domain; Region: CoA_binding_2; pfam13380 1166016010670 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1166016010671 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1166016010672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1166016010673 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1166016010674 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1166016010675 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1166016010676 domain interface [polypeptide binding]; other site 1166016010677 putative active site [active] 1166016010678 catalytic site [active] 1166016010679 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1166016010680 domain interface [polypeptide binding]; other site 1166016010681 putative active site [active] 1166016010682 catalytic site [active] 1166016010683 lipoprotein; Provisional; Region: PRK10759 1166016010684 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1166016010685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016010686 putative substrate translocation pore; other site 1166016010687 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1166016010688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016010689 active site 1166016010690 motif I; other site 1166016010691 motif II; other site 1166016010692 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1166016010693 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1166016010694 Walker A/P-loop; other site 1166016010695 ATP binding site [chemical binding]; other site 1166016010696 Q-loop/lid; other site 1166016010697 ABC transporter signature motif; other site 1166016010698 Walker B; other site 1166016010699 D-loop; other site 1166016010700 H-loop/switch region; other site 1166016010701 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1166016010702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016010703 dimer interface [polypeptide binding]; other site 1166016010704 conserved gate region; other site 1166016010705 ABC-ATPase subunit interface; other site 1166016010706 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1166016010707 lipoprotein, YaeC family; Region: TIGR00363 1166016010708 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1166016010709 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1166016010710 homodimer interaction site [polypeptide binding]; other site 1166016010711 cofactor binding site; other site 1166016010712 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1166016010713 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1166016010714 dimer interface [polypeptide binding]; other site 1166016010715 motif 1; other site 1166016010716 active site 1166016010717 motif 2; other site 1166016010718 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1166016010719 putative deacylase active site [active] 1166016010720 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1166016010721 active site 1166016010722 motif 3; other site 1166016010723 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1166016010724 anticodon binding site; other site 1166016010725 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1166016010726 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1166016010727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1166016010728 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1166016010729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1166016010730 DNA binding residues [nucleotide binding] 1166016010731 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1166016010732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166016010733 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166016010734 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1166016010735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016010736 S-adenosylmethionine binding site [chemical binding]; other site 1166016010737 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1166016010738 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1166016010739 Permutation of conserved domain; other site 1166016010740 active site 1166016010741 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1166016010742 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1166016010743 homotrimer interaction site [polypeptide binding]; other site 1166016010744 zinc binding site [ion binding]; other site 1166016010745 CDP-binding sites; other site 1166016010746 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1166016010747 substrate binding site; other site 1166016010748 dimer interface; other site 1166016010749 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1166016010750 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1166016010751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016010752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016010753 substrate binding pocket [chemical binding]; other site 1166016010754 membrane-bound complex binding site; other site 1166016010755 hinge residues; other site 1166016010756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016010757 dimer interface [polypeptide binding]; other site 1166016010758 conserved gate region; other site 1166016010759 putative PBP binding loops; other site 1166016010760 ABC-ATPase subunit interface; other site 1166016010761 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016010762 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016010763 Walker A/P-loop; other site 1166016010764 ATP binding site [chemical binding]; other site 1166016010765 Q-loop/lid; other site 1166016010766 ABC transporter signature motif; other site 1166016010767 Walker B; other site 1166016010768 D-loop; other site 1166016010769 H-loop/switch region; other site 1166016010770 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1166016010771 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1166016010772 ligand-binding site [chemical binding]; other site 1166016010773 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1166016010774 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1166016010775 CysD dimerization site [polypeptide binding]; other site 1166016010776 G1 box; other site 1166016010777 putative GEF interaction site [polypeptide binding]; other site 1166016010778 GTP/Mg2+ binding site [chemical binding]; other site 1166016010779 Switch I region; other site 1166016010780 G2 box; other site 1166016010781 G3 box; other site 1166016010782 Switch II region; other site 1166016010783 G4 box; other site 1166016010784 G5 box; other site 1166016010785 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1166016010786 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1166016010787 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1166016010788 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1166016010789 Active Sites [active] 1166016010790 siroheme synthase; Provisional; Region: cysG; PRK10637 1166016010791 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1166016010792 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1166016010793 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1166016010794 active site 1166016010795 SAM binding site [chemical binding]; other site 1166016010796 homodimer interface [polypeptide binding]; other site 1166016010797 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016010798 active site 1166016010799 phosphorylation site [posttranslational modification] 1166016010800 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1166016010801 active site 1166016010802 P-loop; other site 1166016010803 phosphorylation site [posttranslational modification] 1166016010804 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1166016010805 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1166016010806 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1166016010807 beta-galactosidase; Region: BGL; TIGR03356 1166016010808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016010809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016010810 DNA binding site [nucleotide binding] 1166016010811 domain linker motif; other site 1166016010812 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1166016010813 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1166016010814 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1166016010815 Active Sites [active] 1166016010816 sulfite reductase subunit beta; Provisional; Region: PRK13504 1166016010817 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166016010818 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166016010819 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1166016010820 Flavodoxin; Region: Flavodoxin_1; pfam00258 1166016010821 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1166016010822 FAD binding pocket [chemical binding]; other site 1166016010823 FAD binding motif [chemical binding]; other site 1166016010824 catalytic residues [active] 1166016010825 NAD binding pocket [chemical binding]; other site 1166016010826 phosphate binding motif [ion binding]; other site 1166016010827 beta-alpha-beta structure motif; other site 1166016010828 PilZ domain; Region: PilZ; pfam07238 1166016010829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166016010830 Zn2+ binding site [ion binding]; other site 1166016010831 Mg2+ binding site [ion binding]; other site 1166016010832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016010833 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1166016010834 active site 1166016010835 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1166016010836 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1166016010837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166016010838 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016010839 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016010840 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016010841 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1166016010842 VRR-NUC domain; Region: VRR_NUC; pfam08774 1166016010843 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1166016010844 PAAR motif; Region: PAAR_motif; pfam05488 1166016010845 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1166016010846 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1166016010847 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1166016010848 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1166016010849 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1166016010850 putative ligand binding residues [chemical binding]; other site 1166016010851 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166016010852 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016010853 N-terminal plug; other site 1166016010854 ligand-binding site [chemical binding]; other site 1166016010855 enolase; Provisional; Region: eno; PRK00077 1166016010856 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1166016010857 dimer interface [polypeptide binding]; other site 1166016010858 metal binding site [ion binding]; metal-binding site 1166016010859 substrate binding pocket [chemical binding]; other site 1166016010860 CTP synthetase; Validated; Region: pyrG; PRK05380 1166016010861 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1166016010862 Catalytic site [active] 1166016010863 active site 1166016010864 UTP binding site [chemical binding]; other site 1166016010865 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1166016010866 active site 1166016010867 putative oxyanion hole; other site 1166016010868 catalytic triad [active] 1166016010869 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1166016010870 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1166016010871 homodimer interface [polypeptide binding]; other site 1166016010872 metal binding site [ion binding]; metal-binding site 1166016010873 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1166016010874 homodimer interface [polypeptide binding]; other site 1166016010875 active site 1166016010876 putative chemical substrate binding site [chemical binding]; other site 1166016010877 metal binding site [ion binding]; metal-binding site 1166016010878 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1166016010879 HD domain; Region: HD_4; pfam13328 1166016010880 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1166016010881 synthetase active site [active] 1166016010882 NTP binding site [chemical binding]; other site 1166016010883 metal binding site [ion binding]; metal-binding site 1166016010884 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1166016010885 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1166016010886 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1166016010887 TRAM domain; Region: TRAM; pfam01938 1166016010888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1166016010889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016010890 S-adenosylmethionine binding site [chemical binding]; other site 1166016010891 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1166016010892 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1166016010893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016010894 dimerization interface [polypeptide binding]; other site 1166016010895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016010896 dimer interface [polypeptide binding]; other site 1166016010897 phosphorylation site [posttranslational modification] 1166016010898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016010899 ATP binding site [chemical binding]; other site 1166016010900 Mg2+ binding site [ion binding]; other site 1166016010901 G-X-G motif; other site 1166016010902 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1166016010903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016010904 active site 1166016010905 phosphorylation site [posttranslational modification] 1166016010906 intermolecular recognition site; other site 1166016010907 dimerization interface [polypeptide binding]; other site 1166016010908 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1166016010909 putative binding surface; other site 1166016010910 active site 1166016010911 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1166016010912 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1166016010913 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1166016010914 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1166016010915 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1166016010916 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1166016010917 active site 1166016010918 tetramer interface [polypeptide binding]; other site 1166016010919 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1166016010920 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1166016010921 active site 1166016010922 tetramer interface [polypeptide binding]; other site 1166016010923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016010924 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016010925 putative substrate translocation pore; other site 1166016010926 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1166016010927 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1166016010928 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1166016010929 PAS domain; Region: PAS_9; pfam13426 1166016010930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016010931 putative active site [active] 1166016010932 heme pocket [chemical binding]; other site 1166016010933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016010934 dimerization interface [polypeptide binding]; other site 1166016010935 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016010936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016010937 dimer interface [polypeptide binding]; other site 1166016010938 putative CheW interface [polypeptide binding]; other site 1166016010939 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1166016010940 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1166016010941 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1166016010942 nucleotide binding pocket [chemical binding]; other site 1166016010943 K-X-D-G motif; other site 1166016010944 catalytic site [active] 1166016010945 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1166016010946 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1166016010947 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1166016010948 Dimer interface [polypeptide binding]; other site 1166016010949 BRCT sequence motif; other site 1166016010950 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1166016010951 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1166016010952 putative ribose interaction site [chemical binding]; other site 1166016010953 putative ADP binding site [chemical binding]; other site 1166016010954 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1166016010955 active site 1166016010956 nucleotide binding site [chemical binding]; other site 1166016010957 HIGH motif; other site 1166016010958 KMSKS motif; other site 1166016010959 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1166016010960 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1166016010961 metal binding triad; other site 1166016010962 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1166016010963 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1166016010964 metal binding triad; other site 1166016010965 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1166016010966 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1166016010967 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1166016010968 putative active site [active] 1166016010969 putative metal binding residues [ion binding]; other site 1166016010970 signature motif; other site 1166016010971 putative triphosphate binding site [ion binding]; other site 1166016010972 SH3 domain-containing protein; Provisional; Region: PRK10884 1166016010973 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1166016010974 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1166016010975 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1166016010976 active site 1166016010977 NTP binding site [chemical binding]; other site 1166016010978 metal binding triad [ion binding]; metal-binding site 1166016010979 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1166016010980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166016010981 Zn2+ binding site [ion binding]; other site 1166016010982 Mg2+ binding site [ion binding]; other site 1166016010983 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1166016010984 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1166016010985 homooctamer interface [polypeptide binding]; other site 1166016010986 active site 1166016010987 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1166016010988 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166016010989 dimer interface [polypeptide binding]; other site 1166016010990 ligand binding site [chemical binding]; other site 1166016010991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016010992 dimerization interface [polypeptide binding]; other site 1166016010993 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016010994 dimer interface [polypeptide binding]; other site 1166016010995 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016010996 putative CheW interface [polypeptide binding]; other site 1166016010997 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1166016010998 dimer interface [polypeptide binding]; other site 1166016010999 substrate binding site [chemical binding]; other site 1166016011000 metal binding sites [ion binding]; metal-binding site 1166016011001 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1166016011002 putative active site pocket [active] 1166016011003 dimerization interface [polypeptide binding]; other site 1166016011004 putative catalytic residue [active] 1166016011005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1166016011006 Family of unknown function (DUF490); Region: DUF490; pfam04357 1166016011007 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1166016011008 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1166016011009 Surface antigen; Region: Bac_surface_Ag; pfam01103 1166016011010 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1166016011011 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1166016011012 Domain of unknown function DUF21; Region: DUF21; pfam01595 1166016011013 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1166016011014 Transporter associated domain; Region: CorC_HlyC; smart01091 1166016011015 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1166016011016 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1166016011017 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1166016011018 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1166016011019 active site 1166016011020 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1166016011021 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1166016011022 active site 1166016011023 metal binding site [ion binding]; metal-binding site 1166016011024 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1166016011025 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1166016011026 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1166016011027 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1166016011028 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1166016011029 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1166016011030 Hemerythrin-like domain; Region: Hr-like; cd12108 1166016011031 Fe binding site [ion binding]; other site 1166016011032 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1166016011033 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1166016011034 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166016011035 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1166016011036 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1166016011037 Protein of unknown function, DUF488; Region: DUF488; cl01246 1166016011038 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1166016011039 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1166016011040 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1166016011041 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1166016011042 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1166016011043 dimer interface [polypeptide binding]; other site 1166016011044 ssDNA binding site [nucleotide binding]; other site 1166016011045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166016011046 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1166016011047 esterase; Provisional; Region: PRK10566 1166016011048 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166016011049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016011050 PAS fold; Region: PAS_4; pfam08448 1166016011051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016011052 dimerization interface [polypeptide binding]; other site 1166016011053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016011055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011056 dimer interface [polypeptide binding]; other site 1166016011057 putative CheW interface [polypeptide binding]; other site 1166016011058 hypothetical protein; Reviewed; Region: PRK09588 1166016011059 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1166016011060 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1166016011061 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1166016011062 Predicted membrane protein [Function unknown]; Region: COG3766 1166016011063 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1166016011064 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1166016011065 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016011066 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016011067 dimerization interface [polypeptide binding]; other site 1166016011068 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016011069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011070 dimer interface [polypeptide binding]; other site 1166016011071 putative CheW interface [polypeptide binding]; other site 1166016011072 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1166016011073 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1166016011074 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166016011075 exoribonuclease R; Provisional; Region: PRK11642 1166016011076 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1166016011077 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1166016011078 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1166016011079 RNB domain; Region: RNB; pfam00773 1166016011080 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1166016011081 RNA binding site [nucleotide binding]; other site 1166016011082 transcriptional repressor NsrR; Provisional; Region: PRK11014 1166016011083 Rrf2 family protein; Region: rrf2_super; TIGR00738 1166016011084 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1166016011085 dimer interface [polypeptide binding]; other site 1166016011086 ligand binding site [chemical binding]; other site 1166016011087 HAMP domain; Region: HAMP; pfam00672 1166016011088 dimerization interface [polypeptide binding]; other site 1166016011089 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016011090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011091 dimer interface [polypeptide binding]; other site 1166016011092 putative CheW interface [polypeptide binding]; other site 1166016011093 PAS domain S-box; Region: sensory_box; TIGR00229 1166016011094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016011095 putative active site [active] 1166016011096 heme pocket [chemical binding]; other site 1166016011097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1166016011098 PAS domain; Region: PAS_9; pfam13426 1166016011099 putative active site [active] 1166016011100 heme pocket [chemical binding]; other site 1166016011101 GAF domain; Region: GAF_2; pfam13185 1166016011102 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016011103 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016011104 metal binding site [ion binding]; metal-binding site 1166016011105 active site 1166016011106 I-site; other site 1166016011107 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1166016011108 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1166016011109 Walker A motif; other site 1166016011110 ATP binding site [chemical binding]; other site 1166016011111 Walker B motif; other site 1166016011112 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1166016011113 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166016011114 catalytic residue [active] 1166016011115 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1166016011116 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1166016011117 YGGT family; Region: YGGT; pfam02325 1166016011118 YGGT family; Region: YGGT; pfam02325 1166016011119 hypothetical protein; Validated; Region: PRK05090 1166016011120 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1166016011121 active site 1166016011122 dimerization interface [polypeptide binding]; other site 1166016011123 HemN family oxidoreductase; Provisional; Region: PRK05660 1166016011124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016011125 FeS/SAM binding site; other site 1166016011126 HemN C-terminal domain; Region: HemN_C; pfam06969 1166016011127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016011128 Coenzyme A binding pocket [chemical binding]; other site 1166016011129 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1166016011130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016011131 putative substrate translocation pore; other site 1166016011132 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1166016011133 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1166016011134 putative acyl-acceptor binding pocket; other site 1166016011135 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1166016011136 acyl-activating enzyme (AAE) consensus motif; other site 1166016011137 putative AMP binding site [chemical binding]; other site 1166016011138 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016011139 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016011140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016011141 dimerization interface [polypeptide binding]; other site 1166016011142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011143 dimer interface [polypeptide binding]; other site 1166016011144 putative CheW interface [polypeptide binding]; other site 1166016011145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166016011146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016011147 Coenzyme A binding pocket [chemical binding]; other site 1166016011148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016011149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016011150 DNA binding site [nucleotide binding] 1166016011151 domain linker motif; other site 1166016011152 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1166016011153 dimerization interface (closed form) [polypeptide binding]; other site 1166016011154 ligand binding site [chemical binding]; other site 1166016011155 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1166016011156 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1166016011157 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1166016011158 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1166016011159 pyruvate kinase; Provisional; Region: PRK05826 1166016011160 domain interfaces; other site 1166016011161 active site 1166016011162 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1166016011163 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1166016011164 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1166016011165 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1166016011166 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1166016011167 active site 1166016011168 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166016011169 substrate binding site [chemical binding]; other site 1166016011170 catalytic residues [active] 1166016011171 dimer interface [polypeptide binding]; other site 1166016011172 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1166016011173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016011174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016011175 dimerization interface [polypeptide binding]; other site 1166016011176 transcriptional activator TtdR; Provisional; Region: PRK09801 1166016011177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016011178 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1166016011179 putative effector binding pocket; other site 1166016011180 dimerization interface [polypeptide binding]; other site 1166016011181 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1166016011182 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1166016011183 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1166016011184 catalytic residues [active] 1166016011185 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1166016011186 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1166016011187 Sel1-like repeats; Region: SEL1; smart00671 1166016011188 Sel1-like repeats; Region: SEL1; smart00671 1166016011189 Sel1-like repeats; Region: SEL1; smart00671 1166016011190 Transglycosylase; Region: Transgly; pfam00912 1166016011191 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1166016011192 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1166016011193 FMN binding site [chemical binding]; other site 1166016011194 active site 1166016011195 catalytic residues [active] 1166016011196 substrate binding site [chemical binding]; other site 1166016011197 phage shock protein G; Reviewed; Region: pspG; PRK09459 1166016011198 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1166016011199 Cytochrome P450; Region: p450; cl12078 1166016011200 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1166016011201 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1166016011202 NADP binding site [chemical binding]; other site 1166016011203 dimer interface [polypeptide binding]; other site 1166016011204 replicative DNA helicase; Provisional; Region: PRK08006 1166016011205 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1166016011206 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1166016011207 Walker A motif; other site 1166016011208 ATP binding site [chemical binding]; other site 1166016011209 Walker B motif; other site 1166016011210 DNA binding loops [nucleotide binding] 1166016011211 alanine racemase; Reviewed; Region: alr; PRK00053 1166016011212 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1166016011213 active site 1166016011214 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166016011215 substrate binding site [chemical binding]; other site 1166016011216 catalytic residues [active] 1166016011217 dimer interface [polypeptide binding]; other site 1166016011218 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1166016011219 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1166016011220 putative DNA binding site [nucleotide binding]; other site 1166016011221 putative Zn2+ binding site [ion binding]; other site 1166016011222 AsnC family; Region: AsnC_trans_reg; pfam01037 1166016011223 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1166016011224 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1166016011225 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1166016011226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016011227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016011228 homodimer interface [polypeptide binding]; other site 1166016011229 catalytic residue [active] 1166016011230 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1166016011231 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016011232 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1166016011233 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1166016011234 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1166016011235 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1166016011236 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1166016011237 Protein of unknown function (DUF1240); Region: DUF1240; pfam06836 1166016011238 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 1166016011239 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 1166016011240 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 1166016011241 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 1166016011242 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1166016011243 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 1166016011244 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 1166016011245 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1166016011246 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1166016011247 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1166016011248 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1166016011249 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1166016011250 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1166016011251 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1166016011252 dimer interface [polypeptide binding]; other site 1166016011253 ssDNA binding site [nucleotide binding]; other site 1166016011254 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166016011255 putative single-stranded DNA-binding protein; Region: PHA01740 1166016011256 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1166016011257 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1166016011258 active site 1166016011259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016011260 Coenzyme A binding pocket [chemical binding]; other site 1166016011261 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1166016011262 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1166016011263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016011264 Coenzyme A binding pocket [chemical binding]; other site 1166016011265 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166016011266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016011267 DNA-binding site [nucleotide binding]; DNA binding site 1166016011268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016011269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016011270 homodimer interface [polypeptide binding]; other site 1166016011271 catalytic residue [active] 1166016011272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016011273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016011274 DNA binding site [nucleotide binding] 1166016011275 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1166016011276 ligand binding site [chemical binding]; other site 1166016011277 dimerization interface [polypeptide binding]; other site 1166016011278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1166016011279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016011280 dimer interface [polypeptide binding]; other site 1166016011281 conserved gate region; other site 1166016011282 putative PBP binding loops; other site 1166016011283 ABC-ATPase subunit interface; other site 1166016011284 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1166016011285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016011286 ABC-ATPase subunit interface; other site 1166016011287 putative PBP binding loops; other site 1166016011288 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1166016011289 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1166016011290 Walker A/P-loop; other site 1166016011291 ATP binding site [chemical binding]; other site 1166016011292 Q-loop/lid; other site 1166016011293 ABC transporter signature motif; other site 1166016011294 Walker B; other site 1166016011295 D-loop; other site 1166016011296 H-loop/switch region; other site 1166016011297 TOBE domain; Region: TOBE_2; pfam08402 1166016011298 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1166016011299 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1166016011300 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1166016011301 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1166016011302 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1166016011303 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1166016011304 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1166016011305 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1166016011306 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1166016011307 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1166016011308 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016011309 ABC-ATPase subunit interface; other site 1166016011310 dimer interface [polypeptide binding]; other site 1166016011311 putative PBP binding regions; other site 1166016011312 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1166016011313 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1166016011314 metal binding site [ion binding]; metal-binding site 1166016011315 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1166016011316 substrate binding site [chemical binding]; other site 1166016011317 activation loop (A-loop); other site 1166016011318 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1166016011319 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1166016011320 metal ion-dependent adhesion site (MIDAS); other site 1166016011321 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1166016011322 metal ion-dependent adhesion site (MIDAS); other site 1166016011323 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1166016011324 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1166016011325 putative metal binding site [ion binding]; other site 1166016011326 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1166016011327 metal ion-dependent adhesion site (MIDAS); other site 1166016011328 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1166016011329 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1166016011330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016011331 active site 1166016011332 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1166016011333 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1166016011334 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1166016011335 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1166016011336 putative metal binding site [ion binding]; other site 1166016011337 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1166016011338 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1166016011339 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1166016011340 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1166016011341 putative metal binding site [ion binding]; other site 1166016011342 tellurite resistance protein terB; Region: terB; cd07176 1166016011343 putative metal binding site [ion binding]; other site 1166016011344 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1166016011345 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1166016011346 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1166016011347 putative metal binding site [ion binding]; other site 1166016011348 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1166016011349 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1166016011350 putative metal binding site [ion binding]; other site 1166016011351 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1166016011352 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166016011353 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166016011354 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166016011355 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016011356 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1166016011357 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1166016011358 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166016011359 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1166016011360 gluconate transporter; Region: gntP; TIGR00791 1166016011361 putative dehydratase; Provisional; Region: PRK08211 1166016011362 Dehydratase family; Region: ILVD_EDD; cl00340 1166016011363 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1166016011364 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1166016011365 inhibitor site; inhibition site 1166016011366 active site 1166016011367 dimer interface [polypeptide binding]; other site 1166016011368 catalytic residue [active] 1166016011369 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1166016011370 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1166016011371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1166016011372 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1166016011373 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1166016011374 putative active site [active] 1166016011375 metal binding site [ion binding]; metal-binding site 1166016011376 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1166016011377 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1166016011378 inhibitor site; inhibition site 1166016011379 active site 1166016011380 dimer interface [polypeptide binding]; other site 1166016011381 catalytic residue [active] 1166016011382 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1166016011383 Na binding site [ion binding]; other site 1166016011384 BNR repeat-like domain; Region: BNR_2; pfam13088 1166016011385 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1166016011386 Asp-box motif; other site 1166016011387 Domain of unknown function (DUF386); Region: DUF386; cl01047 1166016011388 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1166016011389 classical (c) SDRs; Region: SDR_c; cd05233 1166016011390 NAD(P) binding site [chemical binding]; other site 1166016011391 active site 1166016011392 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1166016011393 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1166016011394 dimer interface [polypeptide binding]; other site 1166016011395 active site 1166016011396 glycine loop; other site 1166016011397 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1166016011398 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016011399 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1166016011400 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1166016011401 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016011402 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1166016011403 substrate binding site [chemical binding]; other site 1166016011404 dimer interface [polypeptide binding]; other site 1166016011405 ATP binding site [chemical binding]; other site 1166016011406 D-allose kinase; Provisional; Region: PRK09698 1166016011407 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166016011408 nucleotide binding site [chemical binding]; other site 1166016011409 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1166016011410 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1166016011411 substrate binding site [chemical binding]; other site 1166016011412 hexamer interface [polypeptide binding]; other site 1166016011413 metal binding site [ion binding]; metal-binding site 1166016011414 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016011415 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016011416 TM-ABC transporter signature motif; other site 1166016011417 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016011418 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016011419 TM-ABC transporter signature motif; other site 1166016011420 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166016011421 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016011422 Walker A/P-loop; other site 1166016011423 ATP binding site [chemical binding]; other site 1166016011424 Q-loop/lid; other site 1166016011425 ABC transporter signature motif; other site 1166016011426 Walker B; other site 1166016011427 D-loop; other site 1166016011428 H-loop/switch region; other site 1166016011429 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016011430 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1166016011431 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1166016011432 ligand binding site [chemical binding]; other site 1166016011433 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166016011434 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1166016011435 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016011436 hypothetical protein; Provisional; Region: PRK05248 1166016011437 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1166016011438 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166016011439 intersubunit interface [polypeptide binding]; other site 1166016011440 enterobactin exporter EntS; Provisional; Region: PRK10489 1166016011441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016011442 putative substrate translocation pore; other site 1166016011443 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166016011444 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016011445 ABC-ATPase subunit interface; other site 1166016011446 dimer interface [polypeptide binding]; other site 1166016011447 putative PBP binding regions; other site 1166016011448 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1166016011449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1166016011450 ABC-ATPase subunit interface; other site 1166016011451 dimer interface [polypeptide binding]; other site 1166016011452 putative PBP binding regions; other site 1166016011453 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1166016011454 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1166016011455 Walker A/P-loop; other site 1166016011456 ATP binding site [chemical binding]; other site 1166016011457 Q-loop/lid; other site 1166016011458 ABC transporter signature motif; other site 1166016011459 Walker B; other site 1166016011460 D-loop; other site 1166016011461 H-loop/switch region; other site 1166016011462 Condensation domain; Region: Condensation; pfam00668 1166016011463 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1166016011464 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1166016011465 acyl-activating enzyme (AAE) consensus motif; other site 1166016011466 AMP binding site [chemical binding]; other site 1166016011467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1166016011468 Condensation domain; Region: Condensation; pfam00668 1166016011469 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1166016011470 Condensation domain; Region: Condensation; pfam00668 1166016011471 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1166016011472 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1166016011473 acyl-activating enzyme (AAE) consensus motif; other site 1166016011474 AMP binding site [chemical binding]; other site 1166016011475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1166016011476 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1166016011477 MbtH-like protein; Region: MbtH; cl01279 1166016011478 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1166016011479 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1166016011480 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1166016011481 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016011482 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016011483 ligand-binding site [chemical binding]; other site 1166016011484 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1166016011485 hydrophobic substrate binding pocket; other site 1166016011486 Isochorismatase family; Region: Isochorismatase; pfam00857 1166016011487 active site 1166016011488 conserved cis-peptide bond; other site 1166016011489 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1166016011490 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1166016011491 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1166016011492 substrate binding site [chemical binding]; other site 1166016011493 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1166016011494 substrate binding site [chemical binding]; other site 1166016011495 ligand binding site [chemical binding]; other site 1166016011496 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1166016011497 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1166016011498 hypothetical protein; Reviewed; Region: PRK09588 1166016011499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016011500 dimerization interface [polypeptide binding]; other site 1166016011501 putative DNA binding site [nucleotide binding]; other site 1166016011502 putative Zn2+ binding site [ion binding]; other site 1166016011503 outer membrane receptor FepA; Provisional; Region: PRK13524 1166016011504 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016011505 N-terminal plug; other site 1166016011506 ligand-binding site [chemical binding]; other site 1166016011507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016011508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016011509 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1166016011510 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1166016011511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166016011512 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1166016011513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016011514 putative substrate translocation pore; other site 1166016011515 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1166016011516 Beta-lactamase; Region: Beta-lactamase; pfam00144 1166016011517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016011518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016011519 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1166016011520 putative dimerization interface [polypeptide binding]; other site 1166016011521 putative effector binding pocket; other site 1166016011522 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1166016011523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016011524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016011525 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1166016011526 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1166016011527 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166016011528 E3 interaction surface; other site 1166016011529 lipoyl attachment site [posttranslational modification]; other site 1166016011530 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166016011531 E3 interaction surface; other site 1166016011532 lipoyl attachment site [posttranslational modification]; other site 1166016011533 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1166016011534 E3 interaction surface; other site 1166016011535 lipoyl attachment site [posttranslational modification]; other site 1166016011536 e3 binding domain; Region: E3_binding; pfam02817 1166016011537 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1166016011538 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1166016011539 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1166016011540 dimer interface [polypeptide binding]; other site 1166016011541 TPP-binding site [chemical binding]; other site 1166016011542 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1166016011543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016011544 DNA-binding site [nucleotide binding]; DNA binding site 1166016011545 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1166016011546 aromatic amino acid transporter; Provisional; Region: PRK10238 1166016011547 regulatory protein AmpE; Provisional; Region: PRK10987 1166016011548 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1166016011549 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1166016011550 amidase catalytic site [active] 1166016011551 Zn binding residues [ion binding]; other site 1166016011552 substrate binding site [chemical binding]; other site 1166016011553 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1166016011554 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1166016011555 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1166016011556 dimerization interface [polypeptide binding]; other site 1166016011557 active site 1166016011558 putative major pilin subunit; Provisional; Region: PRK10574 1166016011559 Pilin (bacterial filament); Region: Pilin; pfam00114 1166016011560 hypothetical protein; Provisional; Region: PRK10436 1166016011561 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1166016011562 Walker A motif; other site 1166016011563 ATP binding site [chemical binding]; other site 1166016011564 Walker B motif; other site 1166016011565 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1166016011566 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016011567 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1166016011568 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1166016011569 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1166016011570 active site 1166016011571 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1166016011572 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1166016011573 CoA-binding site [chemical binding]; other site 1166016011574 ATP-binding [chemical binding]; other site 1166016011575 hypothetical protein; Provisional; Region: PRK05287 1166016011576 Domain of unknown function (DUF329); Region: DUF329; cl01144 1166016011577 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1166016011578 active site 1166016011579 8-oxo-dGMP binding site [chemical binding]; other site 1166016011580 nudix motif; other site 1166016011581 metal binding site [ion binding]; metal-binding site 1166016011582 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1166016011583 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1166016011584 SEC-C motif; Region: SEC-C; pfam02810 1166016011585 SecA regulator SecM; Provisional; Region: PRK02943 1166016011586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 1166016011587 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1166016011588 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1166016011589 cell division protein FtsZ; Validated; Region: PRK09330 1166016011590 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1166016011591 nucleotide binding site [chemical binding]; other site 1166016011592 SulA interaction site; other site 1166016011593 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1166016011594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1166016011595 Cell division protein FtsA; Region: FtsA; pfam14450 1166016011596 cell division protein FtsQ; Provisional; Region: PRK10775 1166016011597 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1166016011598 Cell division protein FtsQ; Region: FtsQ; pfam03799 1166016011599 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1166016011600 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1166016011601 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1166016011602 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1166016011603 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166016011604 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166016011605 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166016011606 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1166016011607 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1166016011608 active site 1166016011609 homodimer interface [polypeptide binding]; other site 1166016011610 cell division protein FtsW; Provisional; Region: PRK10774 1166016011611 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1166016011612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166016011613 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1166016011614 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1166016011615 Mg++ binding site [ion binding]; other site 1166016011616 putative catalytic motif [active] 1166016011617 putative substrate binding site [chemical binding]; other site 1166016011618 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1166016011619 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166016011620 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166016011621 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166016011622 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1166016011623 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166016011624 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166016011625 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166016011626 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1166016011627 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1166016011628 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1166016011629 cell division protein FtsL; Provisional; Region: PRK10772 1166016011630 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1166016011631 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1166016011632 cell division protein MraZ; Reviewed; Region: PRK00326 1166016011633 MraZ protein; Region: MraZ; pfam02381 1166016011634 MraZ protein; Region: MraZ; pfam02381 1166016011635 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1166016011636 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1166016011637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016011638 DNA binding site [nucleotide binding] 1166016011639 domain linker motif; other site 1166016011640 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1166016011641 dimerization interface [polypeptide binding]; other site 1166016011642 ligand binding site [chemical binding]; other site 1166016011643 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1166016011644 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1166016011645 putative valine binding site [chemical binding]; other site 1166016011646 dimer interface [polypeptide binding]; other site 1166016011647 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1166016011648 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1166016011649 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166016011650 PYR/PP interface [polypeptide binding]; other site 1166016011651 dimer interface [polypeptide binding]; other site 1166016011652 TPP binding site [chemical binding]; other site 1166016011653 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166016011654 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1166016011655 TPP-binding site [chemical binding]; other site 1166016011656 dimer interface [polypeptide binding]; other site 1166016011657 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1166016011658 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1166016011659 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1166016011660 acyl-activating enzyme (AAE) consensus motif; other site 1166016011661 putative AMP binding site [chemical binding]; other site 1166016011662 putative active site [active] 1166016011663 putative CoA binding site [chemical binding]; other site 1166016011664 2-isopropylmalate synthase; Validated; Region: PRK00915 1166016011665 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1166016011666 active site 1166016011667 catalytic residues [active] 1166016011668 metal binding site [ion binding]; metal-binding site 1166016011669 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1166016011670 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1166016011671 tartrate dehydrogenase; Region: TTC; TIGR02089 1166016011672 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1166016011673 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1166016011674 substrate binding site [chemical binding]; other site 1166016011675 ligand binding site [chemical binding]; other site 1166016011676 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1166016011677 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1166016011678 substrate binding site [chemical binding]; other site 1166016011679 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1166016011680 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1166016011681 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1166016011682 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016011683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016011684 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1166016011685 dimer interface [polypeptide binding]; other site 1166016011686 ligand binding site [chemical binding]; other site 1166016011687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016011688 dimerization interface [polypeptide binding]; other site 1166016011689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011690 dimer interface [polypeptide binding]; other site 1166016011691 putative CheW interface [polypeptide binding]; other site 1166016011692 transcriptional regulator SgrR; Provisional; Region: PRK13626 1166016011693 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1166016011694 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1166016011695 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1166016011696 NmrA-like family; Region: NmrA; pfam05368 1166016011697 NAD(P) binding site [chemical binding]; other site 1166016011698 active site lysine 1166016011699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016011700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016011701 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1166016011702 putative effector binding pocket; other site 1166016011703 putative dimerization interface [polypeptide binding]; other site 1166016011704 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1166016011705 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1166016011706 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1166016011707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016011708 dimer interface [polypeptide binding]; other site 1166016011709 conserved gate region; other site 1166016011710 putative PBP binding loops; other site 1166016011711 ABC-ATPase subunit interface; other site 1166016011712 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1166016011713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016011714 Walker A/P-loop; other site 1166016011715 ATP binding site [chemical binding]; other site 1166016011716 Q-loop/lid; other site 1166016011717 ABC transporter signature motif; other site 1166016011718 Walker B; other site 1166016011719 D-loop; other site 1166016011720 H-loop/switch region; other site 1166016011721 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1166016011722 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 1166016011723 active site 1166016011724 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1166016011725 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166016011726 PYR/PP interface [polypeptide binding]; other site 1166016011727 dimer interface [polypeptide binding]; other site 1166016011728 TPP binding site [chemical binding]; other site 1166016011729 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166016011730 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1166016011731 TPP-binding site [chemical binding]; other site 1166016011732 dimer interface [polypeptide binding]; other site 1166016011733 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1166016011734 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1166016011735 putative valine binding site [chemical binding]; other site 1166016011736 dimer interface [polypeptide binding]; other site 1166016011737 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1166016011738 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1166016011739 Cache domain; Region: Cache_1; pfam02743 1166016011740 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016011741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016011742 metal binding site [ion binding]; metal-binding site 1166016011743 active site 1166016011744 I-site; other site 1166016011745 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016011746 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016011747 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016011748 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016011749 Uncharacterized conserved protein [Function unknown]; Region: COG4104 1166016011750 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016011751 RHS Repeat; Region: RHS_repeat; pfam05593 1166016011752 RHS Repeat; Region: RHS_repeat; pfam05593 1166016011753 RHS Repeat; Region: RHS_repeat; pfam05593 1166016011754 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1166016011755 RHS Repeat; Region: RHS_repeat; cl11982 1166016011756 RHS Repeat; Region: RHS_repeat; pfam05593 1166016011757 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016011758 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1166016011759 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016011760 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016011761 DNA polymerase II; Reviewed; Region: PRK05762 1166016011762 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1166016011763 active site 1166016011764 catalytic site [active] 1166016011765 substrate binding site [chemical binding]; other site 1166016011766 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1166016011767 active site 1166016011768 metal-binding site 1166016011769 ATP-dependent helicase HepA; Validated; Region: PRK04914 1166016011770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016011771 ATP binding site [chemical binding]; other site 1166016011772 putative Mg++ binding site [ion binding]; other site 1166016011773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016011774 nucleotide binding region [chemical binding]; other site 1166016011775 ATP-binding site [chemical binding]; other site 1166016011776 PAAR motif; Region: PAAR_motif; pfam05488 1166016011777 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1166016011778 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1166016011779 active site 1166016011780 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1166016011781 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1166016011782 putative metal binding site [ion binding]; other site 1166016011783 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166016011784 HSP70 interaction site [polypeptide binding]; other site 1166016011785 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1166016011786 OstA-like protein; Region: OstA; pfam03968 1166016011787 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1166016011788 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1166016011789 SurA N-terminal domain; Region: SurA_N; pfam09312 1166016011790 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1166016011791 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1166016011792 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1166016011793 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1166016011794 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1166016011795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016011796 S-adenosylmethionine binding site [chemical binding]; other site 1166016011797 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1166016011798 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1166016011799 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1166016011800 active site 1166016011801 metal binding site [ion binding]; metal-binding site 1166016011802 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1166016011803 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1166016011804 folate binding site [chemical binding]; other site 1166016011805 NADP+ binding site [chemical binding]; other site 1166016011806 hypothetical protein; Provisional; Region: PRK09917 1166016011807 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1166016011808 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1166016011809 LysE type translocator; Region: LysE; cl00565 1166016011810 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1166016011811 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166016011812 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1166016011813 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1166016011814 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1166016011815 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1166016011816 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1166016011817 IMP binding site; other site 1166016011818 dimer interface [polypeptide binding]; other site 1166016011819 interdomain contacts; other site 1166016011820 partial ornithine binding site; other site 1166016011821 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1166016011822 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1166016011823 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1166016011824 catalytic site [active] 1166016011825 subunit interface [polypeptide binding]; other site 1166016011826 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1166016011827 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1166016011828 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1166016011829 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1166016011830 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1166016011831 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1166016011832 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166016011833 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1166016011834 lipoprotein signal peptidase; Provisional; Region: PRK14787 1166016011835 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1166016011836 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1166016011837 active site 1166016011838 HIGH motif; other site 1166016011839 nucleotide binding site [chemical binding]; other site 1166016011840 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1166016011841 active site 1166016011842 KMSKS motif; other site 1166016011843 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1166016011844 tRNA binding surface [nucleotide binding]; other site 1166016011845 anticodon binding site; other site 1166016011846 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1166016011847 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1166016011848 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1166016011849 active site 1166016011850 Riboflavin kinase; Region: Flavokinase; smart00904 1166016011851 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1166016011852 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1166016011853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016011854 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1166016011855 putative dimerization interface [polypeptide binding]; other site 1166016011856 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1166016011857 chaperone protein DnaJ; Provisional; Region: PRK10767 1166016011858 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166016011859 HSP70 interaction site [polypeptide binding]; other site 1166016011860 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1166016011861 substrate binding site [polypeptide binding]; other site 1166016011862 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1166016011863 Zn binding sites [ion binding]; other site 1166016011864 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1166016011865 dimer interface [polypeptide binding]; other site 1166016011866 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1166016011867 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1166016011868 nucleotide binding site [chemical binding]; other site 1166016011869 hypothetical protein; Provisional; Region: PRK10659 1166016011870 metabolite-proton symporter; Region: 2A0106; TIGR00883 1166016011871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016011872 putative substrate translocation pore; other site 1166016011873 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1166016011874 MPT binding site; other site 1166016011875 trimer interface [polypeptide binding]; other site 1166016011876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016011877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016011878 metal binding site [ion binding]; metal-binding site 1166016011879 active site 1166016011880 I-site; other site 1166016011881 transaldolase-like protein; Provisional; Region: PTZ00411 1166016011882 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1166016011883 active site 1166016011884 dimer interface [polypeptide binding]; other site 1166016011885 catalytic residue [active] 1166016011886 hypothetical protein; Validated; Region: PRK02101 1166016011887 threonine synthase; Validated; Region: PRK09225 1166016011888 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1166016011889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1166016011890 catalytic residue [active] 1166016011891 homoserine kinase; Provisional; Region: PRK01212 1166016011892 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1166016011893 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1166016011894 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1166016011895 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1166016011896 putative catalytic residues [active] 1166016011897 putative nucleotide binding site [chemical binding]; other site 1166016011898 putative aspartate binding site [chemical binding]; other site 1166016011899 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1166016011900 dimer interface [polypeptide binding]; other site 1166016011901 putative threonine allosteric regulatory site; other site 1166016011902 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1166016011903 putative threonine allosteric regulatory site; other site 1166016011904 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1166016011905 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1166016011906 putative RNA methyltransferase; Provisional; Region: PRK10433 1166016011907 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1166016011908 two-component response regulator; Provisional; Region: PRK11173 1166016011909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016011910 active site 1166016011911 phosphorylation site [posttranslational modification] 1166016011912 intermolecular recognition site; other site 1166016011913 dimerization interface [polypeptide binding]; other site 1166016011914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016011915 DNA binding site [nucleotide binding] 1166016011916 hypothetical protein; Provisional; Region: PRK10756 1166016011917 CreA protein; Region: CreA; pfam05981 1166016011918 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1166016011919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016011920 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1166016011921 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1166016011922 catalytic core [active] 1166016011923 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1166016011924 Trp operon repressor; Provisional; Region: PRK01381 1166016011925 lytic murein transglycosylase; Provisional; Region: PRK11619 1166016011926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016011927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016011928 catalytic residue [active] 1166016011929 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1166016011930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016011931 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016011932 ABC transporter; Region: ABC_tran_2; pfam12848 1166016011933 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016011934 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1166016011935 dimer interface [polypeptide binding]; other site 1166016011936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016011937 dimerization interface [polypeptide binding]; other site 1166016011938 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016011939 dimer interface [polypeptide binding]; other site 1166016011940 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016011941 putative CheW interface [polypeptide binding]; other site 1166016011942 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1166016011943 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1166016011944 putative NAD(P) binding site [chemical binding]; other site 1166016011945 dimer interface [polypeptide binding]; other site 1166016011946 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1166016011947 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1166016011948 ligand binding site [chemical binding]; other site 1166016011949 NAD binding site [chemical binding]; other site 1166016011950 tetramer interface [polypeptide binding]; other site 1166016011951 catalytic site [active] 1166016011952 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1166016011953 L-serine binding site [chemical binding]; other site 1166016011954 ACT domain interface; other site 1166016011955 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1166016011956 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166016011957 active site 1166016011958 dimer interface [polypeptide binding]; other site 1166016011959 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1166016011960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016011961 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1166016011962 putative dimerization interface [polypeptide binding]; other site 1166016011963 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1166016011964 oxidative stress defense protein; Provisional; Region: PRK11087 1166016011965 arginine exporter protein; Provisional; Region: PRK09304 1166016011966 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1166016011967 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1166016011968 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166016011969 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1166016011970 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016011971 Walker A/P-loop; other site 1166016011972 ATP binding site [chemical binding]; other site 1166016011973 Q-loop/lid; other site 1166016011974 ABC transporter signature motif; other site 1166016011975 Walker B; other site 1166016011976 D-loop; other site 1166016011977 H-loop/switch region; other site 1166016011978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016011979 Walker A/P-loop; other site 1166016011980 ATP binding site [chemical binding]; other site 1166016011981 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166016011982 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016011983 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016011984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016011985 TM-ABC transporter signature motif; other site 1166016011986 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1166016011987 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 1166016011988 putative ligand binding site [chemical binding]; other site 1166016011989 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1166016011990 Strictosidine synthase; Region: Str_synth; pfam03088 1166016011991 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1166016011992 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1166016011993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016011994 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016011995 putative substrate translocation pore; other site 1166016011996 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1166016011997 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1166016011998 putative N- and C-terminal domain interface [polypeptide binding]; other site 1166016011999 putative active site [active] 1166016012000 MgATP binding site [chemical binding]; other site 1166016012001 catalytic site [active] 1166016012002 metal binding site [ion binding]; metal-binding site 1166016012003 putative xylulose binding site [chemical binding]; other site 1166016012004 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1166016012005 active site 1166016012006 dimer interface [polypeptide binding]; other site 1166016012007 magnesium binding site [ion binding]; other site 1166016012008 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1166016012009 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1166016012010 AP (apurinic/apyrimidinic) site pocket; other site 1166016012011 DNA interaction; other site 1166016012012 Metal-binding active site; metal-binding site 1166016012013 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1166016012014 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1166016012015 intersubunit interface [polypeptide binding]; other site 1166016012016 active site 1166016012017 Zn2+ binding site [ion binding]; other site 1166016012018 mechanosensitive channel MscS; Provisional; Region: PRK10334 1166016012019 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166016012020 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1166016012021 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1166016012022 active site 1166016012023 intersubunit interface [polypeptide binding]; other site 1166016012024 zinc binding site [ion binding]; other site 1166016012025 Na+ binding site [ion binding]; other site 1166016012026 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1166016012027 Phosphoglycerate kinase; Region: PGK; pfam00162 1166016012028 substrate binding site [chemical binding]; other site 1166016012029 hinge regions; other site 1166016012030 ADP binding site [chemical binding]; other site 1166016012031 catalytic site [active] 1166016012032 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1166016012033 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1166016012034 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1166016012035 transketolase; Reviewed; Region: PRK12753 1166016012036 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1166016012037 TPP-binding site [chemical binding]; other site 1166016012038 dimer interface [polypeptide binding]; other site 1166016012039 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1166016012040 PYR/PP interface [polypeptide binding]; other site 1166016012041 dimer interface [polypeptide binding]; other site 1166016012042 TPP binding site [chemical binding]; other site 1166016012043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1166016012044 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1166016012045 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1166016012046 DNA binding residues [nucleotide binding] 1166016012047 dimerization interface [polypeptide binding]; other site 1166016012048 arginine decarboxylase; Provisional; Region: PRK05354 1166016012049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1166016012050 dimer interface [polypeptide binding]; other site 1166016012051 active site 1166016012052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166016012053 catalytic residues [active] 1166016012054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1166016012055 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1166016012056 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1166016012057 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1166016012058 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1166016012059 hypothetical protein; Provisional; Region: PRK04860 1166016012060 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1166016012061 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1166016012062 DNA-specific endonuclease I; Provisional; Region: PRK15137 1166016012063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1166016012064 RNA methyltransferase, RsmE family; Region: TIGR00046 1166016012065 glutathione synthetase; Provisional; Region: PRK05246 1166016012066 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1166016012067 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1166016012068 hypothetical protein; Validated; Region: PRK00228 1166016012069 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1166016012070 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1166016012071 AMP binding site [chemical binding]; other site 1166016012072 metal binding site [ion binding]; metal-binding site 1166016012073 active site 1166016012074 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1166016012075 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1166016012076 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1166016012077 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1166016012078 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1166016012079 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1166016012080 GDP-binding site [chemical binding]; other site 1166016012081 ACT binding site; other site 1166016012082 IMP binding site; other site 1166016012083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1166016012084 FtsH protease regulator HflC; Provisional; Region: PRK11029 1166016012085 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1166016012086 FtsH protease regulator HflK; Provisional; Region: PRK10930 1166016012087 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1166016012088 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1166016012089 GTPase HflX; Provisional; Region: PRK11058 1166016012090 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1166016012091 HflX GTPase family; Region: HflX; cd01878 1166016012092 G1 box; other site 1166016012093 GTP/Mg2+ binding site [chemical binding]; other site 1166016012094 Switch I region; other site 1166016012095 G2 box; other site 1166016012096 G3 box; other site 1166016012097 Switch II region; other site 1166016012098 G4 box; other site 1166016012099 G5 box; other site 1166016012100 bacterial Hfq-like; Region: Hfq; cd01716 1166016012101 hexamer interface [polypeptide binding]; other site 1166016012102 Sm1 motif; other site 1166016012103 RNA binding site [nucleotide binding]; other site 1166016012104 Sm2 motif; other site 1166016012105 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1166016012106 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1166016012107 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1166016012108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016012109 ATP binding site [chemical binding]; other site 1166016012110 Mg2+ binding site [ion binding]; other site 1166016012111 G-X-G motif; other site 1166016012112 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1166016012113 ATP binding site [chemical binding]; other site 1166016012114 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1166016012115 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1166016012116 AMIN domain; Region: AMIN; pfam11741 1166016012117 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1166016012118 active site 1166016012119 metal binding site [ion binding]; metal-binding site 1166016012120 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166016012121 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1166016012122 ADP-binding protein; Provisional; Region: PRK10646 1166016012123 putative carbohydrate kinase; Provisional; Region: PRK10565 1166016012124 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1166016012125 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1166016012126 putative substrate binding site [chemical binding]; other site 1166016012127 putative ATP binding site [chemical binding]; other site 1166016012128 epoxyqueuosine reductase; Region: TIGR00276 1166016012129 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1166016012130 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1166016012131 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1166016012132 catalytic residue [active] 1166016012133 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1166016012134 catalytic residues [active] 1166016012135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016012136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016012137 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1166016012138 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1166016012139 dimer interface [polypeptide binding]; other site 1166016012140 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1166016012141 catalytic triad [active] 1166016012142 peroxidatic and resolving cysteines [active] 1166016012143 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1166016012144 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1166016012145 active site 1166016012146 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1166016012147 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1166016012148 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1166016012149 Integrase; Region: Integrase_1; pfam12835 1166016012150 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1166016012151 Integrase; Region: Integrase_1; pfam12835 1166016012152 Homeodomain-like domain; Region: HTH_23; pfam13384 1166016012153 Winged helix-turn helix; Region: HTH_29; pfam13551 1166016012154 Homeodomain-like domain; Region: HTH_32; pfam13565 1166016012155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1166016012156 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1166016012157 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1166016012158 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016012159 DNA binding site [nucleotide binding] 1166016012160 active site 1166016012161 Int/Topo IB signature motif; other site 1166016012162 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1166016012163 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1166016012164 catalytic site [active] 1166016012165 putative active site [active] 1166016012166 putative substrate binding site [chemical binding]; other site 1166016012167 dimer interface [polypeptide binding]; other site 1166016012168 GTPase RsgA; Reviewed; Region: PRK12288 1166016012169 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1166016012170 RNA binding site [nucleotide binding]; other site 1166016012171 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1166016012172 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1166016012173 GTP/Mg2+ binding site [chemical binding]; other site 1166016012174 G4 box; other site 1166016012175 G5 box; other site 1166016012176 G1 box; other site 1166016012177 Switch I region; other site 1166016012178 G2 box; other site 1166016012179 G3 box; other site 1166016012180 Switch II region; other site 1166016012181 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1166016012182 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1166016012183 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1166016012184 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1166016012185 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1166016012186 poxB regulator PoxA; Provisional; Region: PRK09350 1166016012187 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1166016012188 motif 1; other site 1166016012189 dimer interface [polypeptide binding]; other site 1166016012190 active site 1166016012191 motif 2; other site 1166016012192 motif 3; other site 1166016012193 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1166016012194 L-aspartate oxidase; Provisional; Region: PRK06175 1166016012195 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1166016012196 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1166016012197 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1166016012198 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1166016012199 D-subunit interface [polypeptide binding]; other site 1166016012200 Iron-sulfur protein interface; other site 1166016012201 proximal quinone binding site [chemical binding]; other site 1166016012202 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1166016012203 Iron-sulfur protein interface; other site 1166016012204 proximal quinone binding site [chemical binding]; other site 1166016012205 C-subunit interface; other site 1166016012206 distal quinone binding site; other site 1166016012207 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1166016012208 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1166016012209 Protein of unknown function, DUF486; Region: DUF486; cl01236 1166016012210 Predicted small secreted protein [Function unknown]; Region: COG5510 1166016012211 elongation factor P; Validated; Region: PRK00529 1166016012212 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1166016012213 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1166016012214 RNA binding site [nucleotide binding]; other site 1166016012215 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1166016012216 RNA binding site [nucleotide binding]; other site 1166016012217 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1166016012218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016012219 FeS/SAM binding site; other site 1166016012220 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1166016012221 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1166016012222 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1166016012223 active site 1166016012224 dimer interface [polypeptide binding]; other site 1166016012225 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1166016012226 dimer interface [polypeptide binding]; other site 1166016012227 active site 1166016012228 aspartate kinase III; Validated; Region: PRK09084 1166016012229 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1166016012230 nucleotide binding site [chemical binding]; other site 1166016012231 substrate binding site [chemical binding]; other site 1166016012232 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1166016012233 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1166016012234 dimer interface [polypeptide binding]; other site 1166016012235 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1166016012236 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1166016012237 PhoU domain; Region: PhoU; pfam01895 1166016012238 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1166016012239 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1166016012240 transmembrane helices; other site 1166016012241 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1166016012242 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1166016012243 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1166016012244 substrate binding pocket [chemical binding]; other site 1166016012245 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1166016012246 B12 binding site [chemical binding]; other site 1166016012247 cobalt ligand [ion binding]; other site 1166016012248 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1166016012249 transcriptional repressor IclR; Provisional; Region: PRK11569 1166016012250 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1166016012251 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166016012252 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1166016012253 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1166016012254 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1166016012255 putative acyl-acceptor binding pocket; other site 1166016012256 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1166016012257 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1166016012258 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1166016012259 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1166016012260 isocitrate lyase; Provisional; Region: PRK15063 1166016012261 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1166016012262 tetramer interface [polypeptide binding]; other site 1166016012263 active site 1166016012264 Mg2+/Mn2+ binding site [ion binding]; other site 1166016012265 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1166016012266 malate synthase A; Region: malate_syn_A; TIGR01344 1166016012267 active site 1166016012268 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1166016012269 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1166016012270 proposed active site lysine [active] 1166016012271 conserved cys residue [active] 1166016012272 hypothetical protein; Provisional; Region: PRK10039 1166016012273 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1166016012274 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1166016012275 trimer interface [polypeptide binding]; other site 1166016012276 putative metal binding site [ion binding]; other site 1166016012277 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1166016012278 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1166016012279 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1166016012280 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1166016012281 shikimate binding site; other site 1166016012282 NAD(P) binding site [chemical binding]; other site 1166016012283 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1166016012284 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016012285 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1166016012286 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016012287 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1166016012288 hypothetical protein; Validated; Region: PRK03430 1166016012289 hypothetical protein; Provisional; Region: PRK10736 1166016012290 DNA protecting protein DprA; Region: dprA; TIGR00732 1166016012291 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1166016012292 active site 1166016012293 catalytic residues [active] 1166016012294 metal binding site [ion binding]; metal-binding site 1166016012295 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1166016012296 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1166016012297 putative active site [active] 1166016012298 substrate binding site [chemical binding]; other site 1166016012299 putative cosubstrate binding site; other site 1166016012300 catalytic site [active] 1166016012301 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1166016012302 substrate binding site [chemical binding]; other site 1166016012303 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1166016012304 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1166016012305 putative RNA binding site [nucleotide binding]; other site 1166016012306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016012307 S-adenosylmethionine binding site [chemical binding]; other site 1166016012308 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1166016012309 TrkA-N domain; Region: TrkA_N; pfam02254 1166016012310 TrkA-C domain; Region: TrkA_C; pfam02080 1166016012311 TrkA-N domain; Region: TrkA_N; pfam02254 1166016012312 TrkA-C domain; Region: TrkA_C; pfam02080 1166016012313 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1166016012314 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1166016012315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1166016012316 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1166016012317 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1166016012318 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1166016012319 alphaNTD homodimer interface [polypeptide binding]; other site 1166016012320 alphaNTD - beta interaction site [polypeptide binding]; other site 1166016012321 alphaNTD - beta' interaction site [polypeptide binding]; other site 1166016012322 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1166016012323 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1166016012324 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1166016012325 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016012326 RNA binding surface [nucleotide binding]; other site 1166016012327 30S ribosomal protein S11; Validated; Region: PRK05309 1166016012328 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1166016012329 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1166016012330 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1166016012331 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1166016012332 SecY translocase; Region: SecY; pfam00344 1166016012333 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1166016012334 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1166016012335 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1166016012336 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1166016012337 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1166016012338 5S rRNA interface [nucleotide binding]; other site 1166016012339 23S rRNA interface [nucleotide binding]; other site 1166016012340 L5 interface [polypeptide binding]; other site 1166016012341 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1166016012342 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1166016012343 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1166016012344 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1166016012345 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1166016012346 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1166016012347 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1166016012348 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1166016012349 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1166016012350 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1166016012351 RNA binding site [nucleotide binding]; other site 1166016012352 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1166016012353 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1166016012354 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1166016012355 23S rRNA interface [nucleotide binding]; other site 1166016012356 putative translocon interaction site; other site 1166016012357 signal recognition particle (SRP54) interaction site; other site 1166016012358 L23 interface [polypeptide binding]; other site 1166016012359 trigger factor interaction site; other site 1166016012360 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1166016012361 23S rRNA interface [nucleotide binding]; other site 1166016012362 5S rRNA interface [nucleotide binding]; other site 1166016012363 putative antibiotic binding site [chemical binding]; other site 1166016012364 L25 interface [polypeptide binding]; other site 1166016012365 L27 interface [polypeptide binding]; other site 1166016012366 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1166016012367 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1166016012368 G-X-X-G motif; other site 1166016012369 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1166016012370 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1166016012371 protein-rRNA interface [nucleotide binding]; other site 1166016012372 putative translocon binding site; other site 1166016012373 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1166016012374 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1166016012375 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1166016012376 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1166016012377 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1166016012378 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1166016012379 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1166016012380 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1166016012381 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1166016012382 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1166016012383 heme binding site [chemical binding]; other site 1166016012384 ferroxidase pore; other site 1166016012385 ferroxidase diiron center [ion binding]; other site 1166016012386 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1166016012387 elongation factor Tu; Reviewed; Region: PRK00049 1166016012388 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1166016012389 G1 box; other site 1166016012390 GEF interaction site [polypeptide binding]; other site 1166016012391 GTP/Mg2+ binding site [chemical binding]; other site 1166016012392 Switch I region; other site 1166016012393 G2 box; other site 1166016012394 G3 box; other site 1166016012395 Switch II region; other site 1166016012396 G4 box; other site 1166016012397 G5 box; other site 1166016012398 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1166016012399 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1166016012400 Antibiotic Binding Site [chemical binding]; other site 1166016012401 elongation factor G; Reviewed; Region: PRK00007 1166016012402 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1166016012403 G1 box; other site 1166016012404 putative GEF interaction site [polypeptide binding]; other site 1166016012405 GTP/Mg2+ binding site [chemical binding]; other site 1166016012406 Switch I region; other site 1166016012407 G2 box; other site 1166016012408 G3 box; other site 1166016012409 Switch II region; other site 1166016012410 G4 box; other site 1166016012411 G5 box; other site 1166016012412 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1166016012413 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1166016012414 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1166016012415 30S ribosomal protein S7; Validated; Region: PRK05302 1166016012416 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1166016012417 S17 interaction site [polypeptide binding]; other site 1166016012418 S8 interaction site; other site 1166016012419 16S rRNA interaction site [nucleotide binding]; other site 1166016012420 streptomycin interaction site [chemical binding]; other site 1166016012421 23S rRNA interaction site [nucleotide binding]; other site 1166016012422 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1166016012423 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1166016012424 sulfur relay protein TusC; Validated; Region: PRK00211 1166016012425 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1166016012426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1166016012427 YheO-like PAS domain; Region: PAS_6; pfam08348 1166016012428 HTH domain; Region: HTH_22; pfam13309 1166016012429 putative metal dependent hydrolase; Provisional; Region: PRK11598 1166016012430 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1166016012431 Sulfatase; Region: Sulfatase; pfam00884 1166016012432 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1166016012433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016012434 active site 1166016012435 phosphorylation site [posttranslational modification] 1166016012436 intermolecular recognition site; other site 1166016012437 dimerization interface [polypeptide binding]; other site 1166016012438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016012439 DNA binding site [nucleotide binding] 1166016012440 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1166016012441 HAMP domain; Region: HAMP; pfam00672 1166016012442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016012443 dimer interface [polypeptide binding]; other site 1166016012444 phosphorylation site [posttranslational modification] 1166016012445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016012446 ATP binding site [chemical binding]; other site 1166016012447 Mg2+ binding site [ion binding]; other site 1166016012448 G-X-G motif; other site 1166016012449 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1166016012450 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1166016012451 dimer interface [polypeptide binding]; other site 1166016012452 active site 1166016012453 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1166016012454 folate binding site [chemical binding]; other site 1166016012455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1166016012456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1166016012457 catalytic residue [active] 1166016012458 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1166016012459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016012460 DNA-binding site [nucleotide binding]; DNA binding site 1166016012461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1166016012462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016012463 homodimer interface [polypeptide binding]; other site 1166016012464 catalytic residue [active] 1166016012465 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1166016012466 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1166016012467 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166016012468 phi X174 lysis protein; Provisional; Region: PRK02793 1166016012469 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1166016012470 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1166016012471 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 1166016012472 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1166016012473 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1166016012474 TrkA-N domain; Region: TrkA_N; pfam02254 1166016012475 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1166016012476 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1166016012477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016012478 Walker A/P-loop; other site 1166016012479 ATP binding site [chemical binding]; other site 1166016012480 Q-loop/lid; other site 1166016012481 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016012482 ABC transporter signature motif; other site 1166016012483 Walker B; other site 1166016012484 D-loop; other site 1166016012485 ABC transporter; Region: ABC_tran_2; pfam12848 1166016012486 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1166016012487 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166016012488 putative hydrolase; Provisional; Region: PRK10985 1166016012489 hypothetical protein; Provisional; Region: PRK04966 1166016012490 phosphoribulokinase; Provisional; Region: PRK15453 1166016012491 active site 1166016012492 hypothetical protein; Provisional; Region: PRK10738 1166016012493 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1166016012494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1166016012495 ligand binding site [chemical binding]; other site 1166016012496 flexible hinge region; other site 1166016012497 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1166016012498 putative switch regulator; other site 1166016012499 non-specific DNA interactions [nucleotide binding]; other site 1166016012500 DNA binding site [nucleotide binding] 1166016012501 sequence specific DNA binding site [nucleotide binding]; other site 1166016012502 putative cAMP binding site [chemical binding]; other site 1166016012503 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1166016012504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1166016012505 inhibitor-cofactor binding pocket; inhibition site 1166016012506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016012507 catalytic residue [active] 1166016012508 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1166016012509 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1166016012510 glutamine binding [chemical binding]; other site 1166016012511 catalytic triad [active] 1166016012512 Pectate lyase; Region: Pec_lyase_C; pfam00544 1166016012513 Pectate lyase; Region: Pec_lyase_C; cl01593 1166016012514 Pectate lyase; Region: Pec_lyase_C; pfam00544 1166016012515 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1166016012516 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1166016012517 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1166016012518 substrate binding site [chemical binding]; other site 1166016012519 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1166016012520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016012521 Walker A/P-loop; other site 1166016012522 ATP binding site [chemical binding]; other site 1166016012523 Q-loop/lid; other site 1166016012524 ABC transporter signature motif; other site 1166016012525 Walker B; other site 1166016012526 D-loop; other site 1166016012527 H-loop/switch region; other site 1166016012528 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1166016012529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016012530 Walker A/P-loop; other site 1166016012531 ATP binding site [chemical binding]; other site 1166016012532 Q-loop/lid; other site 1166016012533 ABC transporter signature motif; other site 1166016012534 Walker B; other site 1166016012535 D-loop; other site 1166016012536 H-loop/switch region; other site 1166016012537 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016012538 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166016012539 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166016012540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016012541 dimer interface [polypeptide binding]; other site 1166016012542 conserved gate region; other site 1166016012543 ABC-ATPase subunit interface; other site 1166016012544 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166016012545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016012546 dimer interface [polypeptide binding]; other site 1166016012547 conserved gate region; other site 1166016012548 putative PBP binding loops; other site 1166016012549 ABC-ATPase subunit interface; other site 1166016012550 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166016012551 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1166016012552 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1166016012553 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 1166016012554 putative active site pocket [active] 1166016012555 metal binding site [ion binding]; metal-binding site 1166016012556 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1166016012557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016012558 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166016012559 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166016012560 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1166016012561 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1166016012562 siroheme synthase; Provisional; Region: cysG; PRK10637 1166016012563 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1166016012564 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1166016012565 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1166016012566 active site 1166016012567 SAM binding site [chemical binding]; other site 1166016012568 homodimer interface [polypeptide binding]; other site 1166016012569 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016012570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016012571 dimer interface [polypeptide binding]; other site 1166016012572 conserved gate region; other site 1166016012573 putative PBP binding loops; other site 1166016012574 ABC-ATPase subunit interface; other site 1166016012575 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016012576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016012577 dimer interface [polypeptide binding]; other site 1166016012578 conserved gate region; other site 1166016012579 putative PBP binding loops; other site 1166016012580 ABC-ATPase subunit interface; other site 1166016012581 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1166016012582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1166016012583 Walker A/P-loop; other site 1166016012584 ATP binding site [chemical binding]; other site 1166016012585 Q-loop/lid; other site 1166016012586 ABC transporter signature motif; other site 1166016012587 Walker B; other site 1166016012588 D-loop; other site 1166016012589 H-loop/switch region; other site 1166016012590 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016012591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016012592 substrate binding pocket [chemical binding]; other site 1166016012593 membrane-bound complex binding site; other site 1166016012594 hinge residues; other site 1166016012595 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1166016012596 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1166016012597 putative metal binding site [ion binding]; other site 1166016012598 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1166016012599 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1166016012600 active site 1166016012601 HIGH motif; other site 1166016012602 dimer interface [polypeptide binding]; other site 1166016012603 KMSKS motif; other site 1166016012604 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1166016012605 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166016012606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016012607 motif II; other site 1166016012608 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1166016012609 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1166016012610 substrate binding site [chemical binding]; other site 1166016012611 hexamer interface [polypeptide binding]; other site 1166016012612 metal binding site [ion binding]; metal-binding site 1166016012613 DNA adenine methylase; Provisional; Region: PRK10904 1166016012614 hypothetical protein; Reviewed; Region: PRK11901 1166016012615 cell division protein DamX; Validated; Region: PRK10905 1166016012616 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1166016012617 active site 1166016012618 dimer interface [polypeptide binding]; other site 1166016012619 metal binding site [ion binding]; metal-binding site 1166016012620 shikimate kinase; Reviewed; Region: aroK; PRK00131 1166016012621 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1166016012622 ADP binding site [chemical binding]; other site 1166016012623 magnesium binding site [ion binding]; other site 1166016012624 putative shikimate binding site; other site 1166016012625 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 1166016012626 Secretin and TonB N terminus short domain; Region: STN; smart00965 1166016012627 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1166016012628 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1166016012629 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1166016012630 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1166016012631 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1166016012632 Transglycosylase; Region: Transgly; pfam00912 1166016012633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1166016012634 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1166016012635 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1166016012636 ADP-ribose binding site [chemical binding]; other site 1166016012637 dimer interface [polypeptide binding]; other site 1166016012638 active site 1166016012639 nudix motif; other site 1166016012640 metal binding site [ion binding]; metal-binding site 1166016012641 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1166016012642 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1166016012643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016012644 active site 1166016012645 motif I; other site 1166016012646 motif II; other site 1166016012647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1166016012648 RNA binding surface [nucleotide binding]; other site 1166016012649 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1166016012650 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1166016012651 dimerization interface [polypeptide binding]; other site 1166016012652 domain crossover interface; other site 1166016012653 redox-dependent activation switch; other site 1166016012654 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1166016012655 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1166016012656 active site 1166016012657 substrate-binding site [chemical binding]; other site 1166016012658 metal-binding site [ion binding] 1166016012659 ATP binding site [chemical binding]; other site 1166016012660 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1166016012661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016012662 dimerization interface [polypeptide binding]; other site 1166016012663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016012664 dimer interface [polypeptide binding]; other site 1166016012665 phosphorylation site [posttranslational modification] 1166016012666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016012667 ATP binding site [chemical binding]; other site 1166016012668 Mg2+ binding site [ion binding]; other site 1166016012669 G-X-G motif; other site 1166016012670 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1166016012671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016012672 active site 1166016012673 phosphorylation site [posttranslational modification] 1166016012674 intermolecular recognition site; other site 1166016012675 dimerization interface [polypeptide binding]; other site 1166016012676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016012677 DNA binding site [nucleotide binding] 1166016012678 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1166016012679 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1166016012680 intersubunit interface [polypeptide binding]; other site 1166016012681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016012682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1166016012683 putative substrate translocation pore; other site 1166016012684 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166016012685 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1166016012686 N-terminal plug; other site 1166016012687 ligand-binding site [chemical binding]; other site 1166016012688 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1166016012689 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1166016012690 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1166016012691 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1166016012692 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1166016012693 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1166016012694 putative acyl-acceptor binding pocket; other site 1166016012695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1166016012696 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016012697 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1166016012698 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016012699 dimer interface [polypeptide binding]; other site 1166016012700 putative CheW interface [polypeptide binding]; other site 1166016012701 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1166016012702 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1166016012703 dimer interface [polypeptide binding]; other site 1166016012704 active site 1166016012705 citrylCoA binding site [chemical binding]; other site 1166016012706 NADH binding [chemical binding]; other site 1166016012707 cationic pore residues; other site 1166016012708 oxalacetate/citrate binding site [chemical binding]; other site 1166016012709 coenzyme A binding site [chemical binding]; other site 1166016012710 catalytic triad [active] 1166016012711 Sensory domain found in PocR; Region: PocR; pfam10114 1166016012712 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1166016012713 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1166016012714 Histidine kinase; Region: His_kinase; pfam06580 1166016012715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016012716 ATP binding site [chemical binding]; other site 1166016012717 Mg2+ binding site [ion binding]; other site 1166016012718 G-X-G motif; other site 1166016012719 Response regulator receiver domain; Region: Response_reg; pfam00072 1166016012720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016012721 active site 1166016012722 phosphorylation site [posttranslational modification] 1166016012723 intermolecular recognition site; other site 1166016012724 dimerization interface [polypeptide binding]; other site 1166016012725 Nup85 Nucleoporin; Region: Nucleopor_Nup85; pfam07575 1166016012726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016012727 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016012728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016012729 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1166016012730 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1166016012731 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1166016012732 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1166016012733 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1166016012734 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1166016012735 Hexamer interface [polypeptide binding]; other site 1166016012736 Hexagonal pore residue; other site 1166016012737 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1166016012738 amphipathic channel; other site 1166016012739 Asn-Pro-Ala signature motifs; other site 1166016012740 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1166016012741 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1166016012742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016012743 FeS/SAM binding site; other site 1166016012744 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1166016012745 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1166016012746 dimer interface [polypeptide binding]; other site 1166016012747 active site 1166016012748 glycine loop; other site 1166016012749 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1166016012750 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1166016012751 conserved cys residue [active] 1166016012752 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1166016012753 Hexamer interface [polypeptide binding]; other site 1166016012754 Hexagonal pore residue; other site 1166016012755 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1166016012756 putative catalytic cysteine [active] 1166016012757 propanediol utilization protein PduB; Provisional; Region: PRK15415 1166016012758 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1166016012759 putative hexamer interface [polypeptide binding]; other site 1166016012760 putative hexagonal pore; other site 1166016012761 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1166016012762 putative hexamer interface [polypeptide binding]; other site 1166016012763 putative hexagonal pore; other site 1166016012764 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1166016012765 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1166016012766 Hexamer interface [polypeptide binding]; other site 1166016012767 Putative hexagonal pore residue; other site 1166016012768 propionate/acetate kinase; Provisional; Region: PRK12379 1166016012769 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1166016012770 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1166016012771 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1166016012772 Hexamer/Pentamer interface [polypeptide binding]; other site 1166016012773 central pore; other site 1166016012774 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1166016012775 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1166016012776 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1166016012777 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1166016012778 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1166016012779 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1166016012780 putative active site [active] 1166016012781 metal binding site [ion binding]; metal-binding site 1166016012782 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1166016012783 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1166016012784 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1166016012785 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1166016012786 RNA binding site [nucleotide binding]; other site 1166016012787 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1166016012788 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1166016012789 Bacterial transcriptional regulator; Region: IclR; pfam01614 1166016012790 2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812 1166016012791 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1166016012792 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1166016012793 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1166016012794 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1166016012795 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1166016012796 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1166016012797 Walker A/P-loop; other site 1166016012798 ATP binding site [chemical binding]; other site 1166016012799 Q-loop/lid; other site 1166016012800 ABC transporter signature motif; other site 1166016012801 Walker B; other site 1166016012802 D-loop; other site 1166016012803 H-loop/switch region; other site 1166016012804 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1166016012805 dimer interface [polypeptide binding]; other site 1166016012806 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1166016012807 active site 1166016012808 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1166016012809 Protein export membrane protein; Region: SecD_SecF; cl14618 1166016012810 carboxylesterase BioH; Provisional; Region: PRK10349 1166016012811 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1166016012812 DNA utilization protein GntX; Provisional; Region: PRK11595 1166016012813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016012814 active site 1166016012815 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1166016012816 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1166016012817 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1166016012818 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1166016012819 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1166016012820 maltodextrin phosphorylase; Provisional; Region: PRK14985 1166016012821 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1166016012822 active site pocket [active] 1166016012823 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1166016012824 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1166016012825 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1166016012826 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1166016012827 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1166016012828 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1166016012829 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1166016012830 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1166016012831 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016012832 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1166016012833 substrate binding site [chemical binding]; other site 1166016012834 dimer interface [polypeptide binding]; other site 1166016012835 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1166016012836 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1166016012837 inhibitor site; inhibition site 1166016012838 active site 1166016012839 dimer interface [polypeptide binding]; other site 1166016012840 catalytic residue [active] 1166016012841 Domain of unknown function (DUF386); Region: DUF386; cl01047 1166016012842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016012843 D-galactonate transporter; Region: 2A0114; TIGR00893 1166016012844 putative substrate translocation pore; other site 1166016012845 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1166016012846 active site residue [active] 1166016012847 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1166016012848 glycogen phosphorylase; Provisional; Region: PRK14986 1166016012849 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1166016012850 homodimer interface [polypeptide binding]; other site 1166016012851 active site pocket [active] 1166016012852 glycogen synthase; Provisional; Region: glgA; PRK00654 1166016012853 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1166016012854 ADP-binding pocket [chemical binding]; other site 1166016012855 homodimer interface [polypeptide binding]; other site 1166016012856 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1166016012857 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1166016012858 ligand binding site; other site 1166016012859 oligomer interface; other site 1166016012860 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1166016012861 dimer interface [polypeptide binding]; other site 1166016012862 N-terminal domain interface [polypeptide binding]; other site 1166016012863 sulfate 1 binding site; other site 1166016012864 glycogen debranching enzyme; Provisional; Region: PRK03705 1166016012865 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1166016012866 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1166016012867 active site 1166016012868 catalytic site [active] 1166016012869 glycogen branching enzyme; Provisional; Region: PRK05402 1166016012870 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1166016012871 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1166016012872 active site 1166016012873 catalytic site [active] 1166016012874 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1166016012875 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1166016012876 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1166016012877 GAF domain; Region: GAF; pfam01590 1166016012878 Histidine kinase; Region: His_kinase; pfam06580 1166016012879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016012880 ATP binding site [chemical binding]; other site 1166016012881 Mg2+ binding site [ion binding]; other site 1166016012882 G-X-G motif; other site 1166016012883 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1166016012884 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1166016012885 putative antibiotic transporter; Provisional; Region: PRK10739 1166016012886 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1166016012887 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1166016012888 Pirin-related protein [General function prediction only]; Region: COG1741 1166016012889 Pirin; Region: Pirin; pfam02678 1166016012890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016012891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016012892 H+ Antiporter protein; Region: 2A0121; TIGR00900 1166016012893 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016012894 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1166016012895 Cysteine-rich domain; Region: CCG; pfam02754 1166016012896 Cysteine-rich domain; Region: CCG; pfam02754 1166016012897 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1166016012898 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1166016012899 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1166016012900 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1166016012901 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1166016012902 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1166016012903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016012904 putative substrate translocation pore; other site 1166016012905 putative hydrolase; Provisional; Region: PRK10976 1166016012906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016012907 active site 1166016012908 motif I; other site 1166016012909 motif II; other site 1166016012910 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1166016012911 lysophospholipase L2; Provisional; Region: PRK10749 1166016012912 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1166016012913 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1166016012914 threonine efflux system; Provisional; Region: PRK10229 1166016012915 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1166016012916 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016012917 ATP binding site [chemical binding]; other site 1166016012918 putative Mg++ binding site [ion binding]; other site 1166016012919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016012920 nucleotide binding region [chemical binding]; other site 1166016012921 ATP-binding site [chemical binding]; other site 1166016012922 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1166016012923 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1166016012924 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1166016012925 dimerization interface [polypeptide binding]; other site 1166016012926 substrate binding site [chemical binding]; other site 1166016012927 active site 1166016012928 calcium binding site [ion binding]; other site 1166016012929 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1166016012930 CoenzymeA binding site [chemical binding]; other site 1166016012931 subunit interaction site [polypeptide binding]; other site 1166016012932 PHB binding site; other site 1166016012933 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1166016012934 EamA-like transporter family; Region: EamA; cl17759 1166016012935 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1166016012936 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1166016012937 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1166016012938 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1166016012939 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1166016012940 Cl binding site [ion binding]; other site 1166016012941 oligomer interface [polypeptide binding]; other site 1166016012942 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1166016012943 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 1166016012944 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1166016012945 Part of AAA domain; Region: AAA_19; pfam13245 1166016012946 Family description; Region: UvrD_C_2; pfam13538 1166016012947 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1166016012948 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1166016012949 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1166016012950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1166016012951 active site 1166016012952 DNA binding site [nucleotide binding] 1166016012953 Int/Topo IB signature motif; other site 1166016012954 hypothetical protein; Provisional; Region: PRK10963 1166016012955 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1166016012956 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1166016012957 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1166016012958 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1166016012959 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1166016012960 putative iron binding site [ion binding]; other site 1166016012961 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1166016012962 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1166016012963 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1166016012964 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1166016012965 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1166016012966 domain interfaces; other site 1166016012967 active site 1166016012968 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1166016012969 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1166016012970 active site 1166016012971 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1166016012972 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1166016012973 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1166016012974 HemY protein N-terminus; Region: HemY_N; pfam07219 1166016012975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1166016012976 TPR motif; other site 1166016012977 binding surface 1166016012978 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1166016012979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016012980 DNA-binding site [nucleotide binding]; DNA binding site 1166016012981 FCD domain; Region: FCD; pfam07729 1166016012982 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1166016012983 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1166016012984 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166016012985 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1166016012986 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1166016012987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016012988 substrate binding pocket [chemical binding]; other site 1166016012989 membrane-bound complex binding site; other site 1166016012990 hinge residues; other site 1166016012991 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1166016012992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016012993 conserved gate region; other site 1166016012994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016012995 dimer interface [polypeptide binding]; other site 1166016012996 conserved gate region; other site 1166016012997 putative PBP binding loops; other site 1166016012998 ABC-ATPase subunit interface; other site 1166016012999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016013000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013001 dimer interface [polypeptide binding]; other site 1166016013002 conserved gate region; other site 1166016013003 putative PBP binding loops; other site 1166016013004 ABC-ATPase subunit interface; other site 1166016013005 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016013006 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016013007 Walker A/P-loop; other site 1166016013008 ATP binding site [chemical binding]; other site 1166016013009 Q-loop/lid; other site 1166016013010 ABC transporter signature motif; other site 1166016013011 Walker B; other site 1166016013012 D-loop; other site 1166016013013 H-loop/switch region; other site 1166016013014 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1166016013015 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1166016013016 metal binding site [ion binding]; metal-binding site 1166016013017 dimer interface [polypeptide binding]; other site 1166016013018 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1166016013019 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1166016013020 Walker A/P-loop; other site 1166016013021 ATP binding site [chemical binding]; other site 1166016013022 Q-loop/lid; other site 1166016013023 ABC transporter signature motif; other site 1166016013024 Walker B; other site 1166016013025 D-loop; other site 1166016013026 H-loop/switch region; other site 1166016013027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1166016013029 dimer interface [polypeptide binding]; other site 1166016013030 conserved gate region; other site 1166016013031 putative PBP binding loops; other site 1166016013032 ABC-ATPase subunit interface; other site 1166016013033 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016013034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016013035 substrate binding pocket [chemical binding]; other site 1166016013036 membrane-bound complex binding site; other site 1166016013037 hinge residues; other site 1166016013038 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166016013039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016013040 Coenzyme A binding pocket [chemical binding]; other site 1166016013041 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1166016013042 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1166016013043 tetramer interface [polypeptide binding]; other site 1166016013044 active site 1166016013045 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1166016013046 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1166016013047 catalytic core [active] 1166016013048 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1166016013049 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1166016013050 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1166016013051 putative active site [active] 1166016013052 metal binding site [ion binding]; metal-binding site 1166016013053 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016013054 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016013055 substrate binding pocket [chemical binding]; other site 1166016013056 membrane-bound complex binding site; other site 1166016013057 hinge residues; other site 1166016013058 putative transport protein YifK; Provisional; Region: PRK10746 1166016013059 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1166016013060 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1166016013061 putative common antigen polymerase; Provisional; Region: PRK02975 1166016013062 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1166016013063 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1166016013064 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1166016013065 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1166016013066 inhibitor-cofactor binding pocket; inhibition site 1166016013067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016013068 catalytic residue [active] 1166016013069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1166016013070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016013071 Coenzyme A binding pocket [chemical binding]; other site 1166016013072 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1166016013073 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1166016013074 NAD binding site [chemical binding]; other site 1166016013075 substrate binding site [chemical binding]; other site 1166016013076 homodimer interface [polypeptide binding]; other site 1166016013077 active site 1166016013078 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1166016013079 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1166016013080 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1166016013081 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1166016013082 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1166016013083 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1166016013084 homodimer interface [polypeptide binding]; other site 1166016013085 active site 1166016013086 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1166016013087 Chain length determinant protein; Region: Wzz; pfam02706 1166016013088 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1166016013089 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1166016013090 Mg++ binding site [ion binding]; other site 1166016013091 putative catalytic motif [active] 1166016013092 substrate binding site [chemical binding]; other site 1166016013093 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1166016013094 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1166016013095 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1166016013096 RNA binding site [nucleotide binding]; other site 1166016013097 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1166016013098 multimer interface [polypeptide binding]; other site 1166016013099 Walker A motif; other site 1166016013100 ATP binding site [chemical binding]; other site 1166016013101 Walker B motif; other site 1166016013102 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1166016013103 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1166016013104 catalytic residues [active] 1166016013105 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1166016013106 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1166016013107 ATP binding site [chemical binding]; other site 1166016013108 Mg++ binding site [ion binding]; other site 1166016013109 motif III; other site 1166016013110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016013111 nucleotide binding region [chemical binding]; other site 1166016013112 ATP-binding site [chemical binding]; other site 1166016013113 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1166016013114 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1166016013115 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1166016013116 Part of AAA domain; Region: AAA_19; pfam13245 1166016013117 Family description; Region: UvrD_C_2; pfam13538 1166016013118 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1166016013119 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1166016013120 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1166016013121 Predicted transcriptional regulator [Transcription]; Region: COG3905 1166016013122 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1166016013123 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1166016013124 Glutamate binding site [chemical binding]; other site 1166016013125 NAD binding site [chemical binding]; other site 1166016013126 catalytic residues [active] 1166016013127 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1166016013128 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1166016013129 Na binding site [ion binding]; other site 1166016013130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016013131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013132 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1166016013133 dimerization interface [polypeptide binding]; other site 1166016013134 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1166016013135 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1166016013136 ketol-acid reductoisomerase; Validated; Region: PRK05225 1166016013137 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1166016013138 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1166016013139 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1166016013140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013141 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1166016013142 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1166016013143 putative dimerization interface [polypeptide binding]; other site 1166016013144 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166016013145 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1166016013146 threonine dehydratase; Reviewed; Region: PRK09224 1166016013147 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1166016013148 tetramer interface [polypeptide binding]; other site 1166016013149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016013150 catalytic residue [active] 1166016013151 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1166016013152 putative Ile/Val binding site [chemical binding]; other site 1166016013153 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1166016013154 putative Ile/Val binding site [chemical binding]; other site 1166016013155 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1166016013156 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1166016013157 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1166016013158 homodimer interface [polypeptide binding]; other site 1166016013159 substrate-cofactor binding pocket; other site 1166016013160 catalytic residue [active] 1166016013161 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1166016013162 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1166016013163 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1166016013164 PYR/PP interface [polypeptide binding]; other site 1166016013165 dimer interface [polypeptide binding]; other site 1166016013166 TPP binding site [chemical binding]; other site 1166016013167 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1166016013168 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1166016013169 TPP-binding site [chemical binding]; other site 1166016013170 dimer interface [polypeptide binding]; other site 1166016013171 putative ATP-dependent protease; Provisional; Region: PRK09862 1166016013172 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1166016013173 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1166016013174 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1166016013175 hypothetical protein; Provisional; Region: PRK11027 1166016013176 transcriptional regulator HdfR; Provisional; Region: PRK03601 1166016013177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016013179 dimerization interface [polypeptide binding]; other site 1166016013180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016013181 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016013182 TM-ABC transporter signature motif; other site 1166016013183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016013184 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016013185 TM-ABC transporter signature motif; other site 1166016013186 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1166016013187 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016013188 Walker A/P-loop; other site 1166016013189 ATP binding site [chemical binding]; other site 1166016013190 Q-loop/lid; other site 1166016013191 ABC transporter signature motif; other site 1166016013192 Walker B; other site 1166016013193 D-loop; other site 1166016013194 H-loop/switch region; other site 1166016013195 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016013196 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1166016013197 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1166016013198 putative ligand binding site [chemical binding]; other site 1166016013199 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1166016013200 potassium transporter; Provisional; Region: PRK10750 1166016013201 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1166016013202 hypothetical protein; Provisional; Region: PRK11568 1166016013203 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1166016013204 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1166016013205 proline dipeptidase; Provisional; Region: PRK13607 1166016013206 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1166016013207 active site 1166016013208 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1166016013209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1166016013210 substrate binding site [chemical binding]; other site 1166016013211 oxyanion hole (OAH) forming residues; other site 1166016013212 trimer interface [polypeptide binding]; other site 1166016013213 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1166016013214 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166016013215 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1166016013216 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1166016013217 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1166016013218 dimer interface [polypeptide binding]; other site 1166016013219 active site 1166016013220 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1166016013221 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016013222 FMN reductase; Validated; Region: fre; PRK08051 1166016013223 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1166016013224 FAD binding pocket [chemical binding]; other site 1166016013225 FAD binding motif [chemical binding]; other site 1166016013226 phosphate binding motif [ion binding]; other site 1166016013227 beta-alpha-beta structure motif; other site 1166016013228 NAD binding pocket [chemical binding]; other site 1166016013229 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1166016013230 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1166016013231 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1166016013232 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1166016013233 dimer interface [polypeptide binding]; other site 1166016013234 allosteric magnesium binding site [ion binding]; other site 1166016013235 active site 1166016013236 aspartate-rich active site metal binding site; other site 1166016013237 Schiff base residues; other site 1166016013238 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1166016013239 active site 1166016013240 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1166016013241 sec-independent translocase; Provisional; Region: PRK01770 1166016013242 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1166016013243 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1166016013244 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1166016013245 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1166016013246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1166016013247 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1166016013248 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1166016013249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016013250 S-adenosylmethionine binding site [chemical binding]; other site 1166016013251 RmuC family; Region: RmuC; pfam02646 1166016013252 argininosuccinate lyase; Provisional; Region: PRK04833 1166016013253 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1166016013254 active sites [active] 1166016013255 tetramer interface [polypeptide binding]; other site 1166016013256 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1166016013257 nucleotide binding site [chemical binding]; other site 1166016013258 N-acetyl-L-glutamate binding site [chemical binding]; other site 1166016013259 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1166016013260 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1166016013261 acetylornithine deacetylase; Provisional; Region: PRK05111 1166016013262 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1166016013263 metal binding site [ion binding]; metal-binding site 1166016013264 putative dimer interface [polypeptide binding]; other site 1166016013265 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1166016013266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016013267 DNA-binding site [nucleotide binding]; DNA binding site 1166016013268 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1166016013269 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1166016013270 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1166016013271 putative active site pocket [active] 1166016013272 putative metal binding site [ion binding]; other site 1166016013273 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1166016013274 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1166016013275 active site turn [active] 1166016013276 phosphorylation site [posttranslational modification] 1166016013277 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1166016013278 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1166016013279 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1166016013280 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1166016013281 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1166016013282 Uncharacterized conserved protein [Function unknown]; Region: COG4104 1166016013283 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016013284 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016013285 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016013286 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016013287 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1166016013288 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016013289 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1166016013290 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016013291 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016013292 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1166016013293 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1166016013294 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1166016013295 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1166016013296 RHS Repeat; Region: RHS_repeat; cl11982 1166016013297 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016013298 RHS Repeat; Region: RHS_repeat; pfam05593 1166016013299 RHS Repeat; Region: RHS_repeat; pfam05593 1166016013300 RHS Repeat; Region: RHS_repeat; pfam05593 1166016013301 RHS Repeat; Region: RHS_repeat; pfam05593 1166016013302 RHS protein; Region: RHS; pfam03527 1166016013303 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016013304 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1166016013305 RHS protein; Region: RHS; pfam03527 1166016013306 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016013307 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1166016013308 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016013309 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1166016013310 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1166016013311 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016013312 RHS Repeat; Region: RHS_repeat; pfam05593 1166016013313 RHS protein; Region: RHS; pfam03527 1166016013314 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1166016013315 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016013316 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1166016013317 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1166016013318 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1166016013319 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 1166016013320 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1166016013321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016013322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016013324 dimerization interface [polypeptide binding]; other site 1166016013325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1166016013326 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1166016013327 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1166016013328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1166016013329 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1166016013330 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1166016013331 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1166016013332 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1166016013333 TolR protein; Region: tolR; TIGR02801 1166016013334 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016013335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013336 dimer interface [polypeptide binding]; other site 1166016013337 conserved gate region; other site 1166016013338 putative PBP binding loops; other site 1166016013339 ABC-ATPase subunit interface; other site 1166016013340 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1166016013341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1166016013342 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1166016013343 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1166016013344 Walker A/P-loop; other site 1166016013345 ATP binding site [chemical binding]; other site 1166016013346 Q-loop/lid; other site 1166016013347 ABC transporter signature motif; other site 1166016013348 Walker B; other site 1166016013349 D-loop; other site 1166016013350 H-loop/switch region; other site 1166016013351 Barstar (barnase inhibitor); Region: Barstar; pfam01337 1166016013352 RNAase interaction site [polypeptide binding]; other site 1166016013353 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1166016013354 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1166016013355 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1166016013356 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1166016013357 uridine phosphorylase; Provisional; Region: PRK11178 1166016013358 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1166016013359 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1166016013360 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1166016013361 CHASE3 domain; Region: CHASE3; cl05000 1166016013362 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016013363 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016013364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016013365 dimerization interface [polypeptide binding]; other site 1166016013366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016013367 dimer interface [polypeptide binding]; other site 1166016013368 putative CheW interface [polypeptide binding]; other site 1166016013369 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1166016013370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016013371 dimerization interface [polypeptide binding]; other site 1166016013372 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016013373 dimer interface [polypeptide binding]; other site 1166016013374 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016013375 putative CheW interface [polypeptide binding]; other site 1166016013376 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1166016013377 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1166016013378 THF binding site; other site 1166016013379 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1166016013380 substrate binding site [chemical binding]; other site 1166016013381 THF binding site; other site 1166016013382 zinc-binding site [ion binding]; other site 1166016013383 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1166016013384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013385 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1166016013386 putative dimerization interface [polypeptide binding]; other site 1166016013387 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1166016013388 EamA-like transporter family; Region: EamA; cl17759 1166016013389 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1166016013390 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1166016013391 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1166016013392 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1166016013393 trimer interface [polypeptide binding]; other site 1166016013394 active site 1166016013395 substrate binding site [chemical binding]; other site 1166016013396 CoA binding site [chemical binding]; other site 1166016013397 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1166016013398 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1166016013399 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1166016013400 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1166016013401 SecA binding site; other site 1166016013402 Preprotein binding site; other site 1166016013403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1166016013404 active site residue [active] 1166016013405 AmiB activator; Provisional; Region: PRK11637 1166016013406 Peptidase family M23; Region: Peptidase_M23; pfam01551 1166016013407 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1166016013408 NodB motif; other site 1166016013409 putative active site [active] 1166016013410 putative catalytic site [active] 1166016013411 Zn binding site [ion binding]; other site 1166016013412 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1166016013413 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1166016013414 NAD(P) binding site [chemical binding]; other site 1166016013415 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1166016013416 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1166016013417 substrate-cofactor binding pocket; other site 1166016013418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1166016013419 catalytic residue [active] 1166016013420 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1166016013421 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1166016013422 NADP binding site [chemical binding]; other site 1166016013423 homopentamer interface [polypeptide binding]; other site 1166016013424 substrate binding site [chemical binding]; other site 1166016013425 active site 1166016013426 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1166016013427 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166016013428 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166016013429 putative active site [active] 1166016013430 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1166016013431 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166016013432 putative active site [active] 1166016013433 O-Antigen ligase; Region: Wzy_C; pfam04932 1166016013434 O-Antigen ligase; Region: Wzy_C; pfam04932 1166016013435 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1166016013436 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1166016013437 putative active site [active] 1166016013438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166016013439 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166016013440 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1166016013441 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1166016013442 Ligand binding site; other site 1166016013443 metal-binding site 1166016013444 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1166016013445 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1166016013446 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1166016013447 Ligand binding site; other site 1166016013448 metal-binding site 1166016013449 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1166016013450 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1166016013451 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1166016013452 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1166016013453 putative metal binding site; other site 1166016013454 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1166016013455 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1166016013456 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1166016013457 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1166016013458 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1166016013459 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1166016013460 active site 1166016013461 (T/H)XGH motif; other site 1166016013462 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1166016013463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1166016013464 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1166016013465 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1166016013466 DNA binding site [nucleotide binding] 1166016013467 catalytic residue [active] 1166016013468 H2TH interface [polypeptide binding]; other site 1166016013469 putative catalytic residues [active] 1166016013470 turnover-facilitating residue; other site 1166016013471 intercalation triad [nucleotide binding]; other site 1166016013472 8OG recognition residue [nucleotide binding]; other site 1166016013473 putative reading head residues; other site 1166016013474 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1166016013475 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1166016013476 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1166016013477 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1166016013478 hypothetical protein; Reviewed; Region: PRK00024 1166016013479 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1166016013480 MPN+ (JAMM) motif; other site 1166016013481 Zinc-binding site [ion binding]; other site 1166016013482 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1166016013483 Flavoprotein; Region: Flavoprotein; pfam02441 1166016013484 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1166016013485 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1166016013486 trimer interface [polypeptide binding]; other site 1166016013487 active site 1166016013488 division inhibitor protein; Provisional; Region: slmA; PRK09480 1166016013489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1166016013490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1166016013491 active site 1166016013492 ribonuclease PH; Reviewed; Region: rph; PRK00173 1166016013493 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1166016013494 hexamer interface [polypeptide binding]; other site 1166016013495 active site 1166016013496 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1166016013497 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1166016013498 active site 1166016013499 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1166016013500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016013501 Walker A/P-loop; other site 1166016013502 ATP binding site [chemical binding]; other site 1166016013503 Q-loop/lid; other site 1166016013504 ABC transporter signature motif; other site 1166016013505 Walker B; other site 1166016013506 D-loop; other site 1166016013507 H-loop/switch region; other site 1166016013508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1166016013509 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016013510 Walker A/P-loop; other site 1166016013511 ATP binding site [chemical binding]; other site 1166016013512 Q-loop/lid; other site 1166016013513 ABC transporter signature motif; other site 1166016013514 Walker B; other site 1166016013515 D-loop; other site 1166016013516 H-loop/switch region; other site 1166016013517 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1166016013518 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1166016013519 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1166016013520 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1166016013521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013522 dimer interface [polypeptide binding]; other site 1166016013523 conserved gate region; other site 1166016013524 putative PBP binding loops; other site 1166016013525 ABC-ATPase subunit interface; other site 1166016013526 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1166016013527 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1166016013528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013529 dimer interface [polypeptide binding]; other site 1166016013530 conserved gate region; other site 1166016013531 putative PBP binding loops; other site 1166016013532 ABC-ATPase subunit interface; other site 1166016013533 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1166016013534 homodimer interface [polypeptide binding]; other site 1166016013535 homotetramer interface [polypeptide binding]; other site 1166016013536 active site pocket [active] 1166016013537 cleavage site 1166016013538 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1166016013539 SxDxEG motif; other site 1166016013540 active site 1166016013541 metal binding site [ion binding]; metal-binding site 1166016013542 homopentamer interface [polypeptide binding]; other site 1166016013543 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1166016013544 catalytic nucleophile [active] 1166016013545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1166016013546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1166016013548 dimerization interface [polypeptide binding]; other site 1166016013549 hypothetical protein; Provisional; Region: PRK11820 1166016013550 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1166016013551 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1166016013552 integrase; Provisional; Region: PRK09692 1166016013553 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1166016013554 active site 1166016013555 Int/Topo IB signature motif; other site 1166016013556 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1166016013557 Prophage antirepressor [Transcription]; Region: COG3617 1166016013558 BRO family, N-terminal domain; Region: Bro-N; smart01040 1166016013559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1166016013560 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1166016013561 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1166016013562 active site 1166016013563 metal binding site [ion binding]; metal-binding site 1166016013564 interdomain interaction site; other site 1166016013565 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1166016013566 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1166016013567 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1166016013568 ssDNA binding site [nucleotide binding]; other site 1166016013569 dimer interface [polypeptide binding]; other site 1166016013570 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1166016013571 putative RNA binding sites [nucleotide binding]; other site 1166016013572 ProQ/FINO family; Region: ProQ; pfam04352 1166016013573 Homeodomain-like domain; Region: HTH_23; cl17451 1166016013574 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1166016013575 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1166016013576 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1166016013577 catalytic residue [active] 1166016013578 Helix-turn-helix domain; Region: HTH_28; pfam13518 1166016013579 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1166016013580 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1166016013581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016013582 non-specific DNA binding site [nucleotide binding]; other site 1166016013583 salt bridge; other site 1166016013584 sequence-specific DNA binding site [nucleotide binding]; other site 1166016013585 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1166016013586 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1166016013587 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1166016013588 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1166016013589 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1166016013590 phosphate binding site [ion binding]; other site 1166016013591 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1166016013592 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1166016013593 NAD binding site [chemical binding]; other site 1166016013594 catalytic residues [active] 1166016013595 substrate binding site [chemical binding]; other site 1166016013596 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1166016013597 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1166016013598 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1166016013599 putative di-iron ligands [ion binding]; other site 1166016013600 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1166016013601 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1166016013602 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1166016013603 putative di-iron ligands [ion binding]; other site 1166016013604 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1166016013605 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1166016013606 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1166016013607 active site 1166016013608 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1166016013609 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 1166016013610 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1166016013611 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1166016013612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016013613 NAD(P) binding site [chemical binding]; other site 1166016013614 active site 1166016013615 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1166016013616 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1166016013617 dimer interface [polypeptide binding]; other site 1166016013618 active site 1166016013619 CoA binding pocket [chemical binding]; other site 1166016013620 GlpM protein; Region: GlpM; pfam06942 1166016013621 acyl-CoA thioesterase; Provisional; Region: PRK10531 1166016013622 putative pectinesterase; Region: PLN02432; cl01911 1166016013623 transcriptional regulator TraR; Provisional; Region: PRK13870 1166016013624 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1166016013625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1166016013626 DNA binding residues [nucleotide binding] 1166016013627 dimerization interface [polypeptide binding]; other site 1166016013628 Autoinducer synthetase; Region: Autoind_synth; pfam00765 1166016013629 argininosuccinate synthase; Validated; Region: PRK05370 1166016013630 DJ-1 family protein; Region: not_thiJ; TIGR01383 1166016013631 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1166016013632 conserved cys residue [active] 1166016013633 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1166016013634 putative dimerization interface [polypeptide binding]; other site 1166016013635 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1166016013636 putative ligand binding site [chemical binding]; other site 1166016013637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1166016013638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1166016013639 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016013640 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016013641 TM-ABC transporter signature motif; other site 1166016013642 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1166016013643 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016013644 Walker A/P-loop; other site 1166016013645 ATP binding site [chemical binding]; other site 1166016013646 Q-loop/lid; other site 1166016013647 ABC transporter signature motif; other site 1166016013648 Walker B; other site 1166016013649 D-loop; other site 1166016013650 H-loop/switch region; other site 1166016013651 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016013652 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1166016013653 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1166016013654 putative ligand binding site [chemical binding]; other site 1166016013655 xylose isomerase; Provisional; Region: PRK05474 1166016013656 xylose isomerase; Region: xylose_isom_A; TIGR02630 1166016013657 xylulokinase; Provisional; Region: PRK15027 1166016013658 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1166016013659 N- and C-terminal domain interface [polypeptide binding]; other site 1166016013660 active site 1166016013661 MgATP binding site [chemical binding]; other site 1166016013662 catalytic site [active] 1166016013663 metal binding site [ion binding]; metal-binding site 1166016013664 xylulose binding site [chemical binding]; other site 1166016013665 homodimer interface [polypeptide binding]; other site 1166016013666 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1166016013667 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1166016013668 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1166016013669 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1166016013670 NAD(P) binding site [chemical binding]; other site 1166016013671 catalytic residues [active] 1166016013672 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1166016013673 superoxide dismutase; Provisional; Region: PRK10925 1166016013674 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1166016013675 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1166016013676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016013677 dimerization interface [polypeptide binding]; other site 1166016013678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016013679 dimer interface [polypeptide binding]; other site 1166016013680 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1166016013681 putative CheW interface [polypeptide binding]; other site 1166016013682 hypothetical protein; Provisional; Region: PRK11020 1166016013683 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1166016013684 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1166016013685 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1166016013686 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1166016013687 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1166016013688 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1166016013689 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1166016013690 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1166016013691 active site 1166016013692 P-loop; other site 1166016013693 phosphorylation site [posttranslational modification] 1166016013694 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1166016013695 active site 1166016013696 phosphorylation site [posttranslational modification] 1166016013697 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1166016013698 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1166016013699 DALR anticodon binding domain; Region: DALR_1; pfam05746 1166016013700 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1166016013701 dimer interface [polypeptide binding]; other site 1166016013702 motif 1; other site 1166016013703 active site 1166016013704 motif 2; other site 1166016013705 motif 3; other site 1166016013706 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1166016013707 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1166016013708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016013709 Coenzyme A binding pocket [chemical binding]; other site 1166016013710 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1166016013711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1166016013712 dimerization interface [polypeptide binding]; other site 1166016013713 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1166016013714 dimer interface [polypeptide binding]; other site 1166016013715 putative CheW interface [polypeptide binding]; other site 1166016013716 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1166016013717 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1166016013718 dimerization interface [polypeptide binding]; other site 1166016013719 ligand binding site [chemical binding]; other site 1166016013720 NADP binding site [chemical binding]; other site 1166016013721 catalytic site [active] 1166016013722 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1166016013723 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1166016013724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1166016013725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013726 dimer interface [polypeptide binding]; other site 1166016013727 conserved gate region; other site 1166016013728 putative PBP binding loops; other site 1166016013729 ABC-ATPase subunit interface; other site 1166016013730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1166016013731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016013732 putative PBP binding loops; other site 1166016013733 dimer interface [polypeptide binding]; other site 1166016013734 ABC-ATPase subunit interface; other site 1166016013735 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1166016013736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016013737 Walker A/P-loop; other site 1166016013738 ATP binding site [chemical binding]; other site 1166016013739 Q-loop/lid; other site 1166016013740 ABC transporter signature motif; other site 1166016013741 Walker B; other site 1166016013742 D-loop; other site 1166016013743 H-loop/switch region; other site 1166016013744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016013745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1166016013746 Walker A/P-loop; other site 1166016013747 ATP binding site [chemical binding]; other site 1166016013748 Q-loop/lid; other site 1166016013749 ABC transporter signature motif; other site 1166016013750 Walker B; other site 1166016013751 D-loop; other site 1166016013752 H-loop/switch region; other site 1166016013753 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1166016013754 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1166016013755 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1166016013756 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1166016013757 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1166016013758 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1166016013759 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1166016013760 putative sugar binding sites [chemical binding]; other site 1166016013761 Q-X-W motif; other site 1166016013762 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1166016013763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1166016013764 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1166016013765 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1166016013766 dimerization interface [polypeptide binding]; other site 1166016013767 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1166016013768 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 1166016013769 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1166016013770 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1166016013771 FAD binding pocket [chemical binding]; other site 1166016013772 FAD binding motif [chemical binding]; other site 1166016013773 phosphate binding motif [ion binding]; other site 1166016013774 NAD binding pocket [chemical binding]; other site 1166016013775 Homeodomain-like domain; Region: HTH_23; pfam13384 1166016013776 glutathione reductase; Validated; Region: PRK06116 1166016013777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016013778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016013779 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1166016013780 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1166016013781 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1166016013782 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1166016013783 HSP70 interaction site [polypeptide binding]; other site 1166016013784 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1166016013785 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1166016013786 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1166016013787 nucleotide binding site [chemical binding]; other site 1166016013788 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1166016013789 SBD interface [polypeptide binding]; other site 1166016013790 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1166016013791 oligopeptidase A; Provisional; Region: PRK10911 1166016013792 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1166016013793 active site 1166016013794 Zn binding site [ion binding]; other site 1166016013795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016013796 S-adenosylmethionine binding site [chemical binding]; other site 1166016013797 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1166016013798 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1166016013799 active site 1166016013800 metal binding site [ion binding]; metal-binding site 1166016013801 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1166016013802 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1166016013803 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1166016013804 glutamate dehydrogenase; Provisional; Region: PRK09414 1166016013805 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1166016013806 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1166016013807 NAD(P) binding site [chemical binding]; other site 1166016013808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1166016013809 Ligand Binding Site [chemical binding]; other site 1166016013810 HTH-like domain; Region: HTH_21; pfam13276 1166016013811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016013812 Integrase core domain; Region: rve; pfam00665 1166016013813 Integrase core domain; Region: rve_3; pfam13683 1166016013814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1166016013815 Transposase; Region: HTH_Tnp_1; pfam01527 1166016013816 universal stress protein UspB; Provisional; Region: PRK04960 1166016013817 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1166016013818 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1166016013819 Predicted flavoproteins [General function prediction only]; Region: COG2081 1166016013820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016013821 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1166016013822 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1166016013823 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1166016013824 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1166016013825 phosphoethanolamine transferase; Provisional; Region: PRK11560 1166016013826 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1166016013827 Sulfatase; Region: Sulfatase; pfam00884 1166016013828 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1166016013829 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1166016013830 nucleotide binding pocket [chemical binding]; other site 1166016013831 K-X-D-G motif; other site 1166016013832 catalytic site [active] 1166016013833 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1166016013834 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1166016013835 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1166016013836 catalytic site [active] 1166016013837 G-X2-G-X-G-K; other site 1166016013838 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1166016013839 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1166016013840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1166016013841 Zn2+ binding site [ion binding]; other site 1166016013842 Mg2+ binding site [ion binding]; other site 1166016013843 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1166016013844 synthetase active site [active] 1166016013845 NTP binding site [chemical binding]; other site 1166016013846 metal binding site [ion binding]; metal-binding site 1166016013847 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1166016013848 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1166016013849 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1166016013850 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1166016013851 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1166016013852 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1166016013853 Y-family of DNA polymerases; Region: PolY; cl12025 1166016013854 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1166016013855 generic binding surface II; other site 1166016013856 ssDNA binding site; other site 1166016013857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1166016013858 ATP binding site [chemical binding]; other site 1166016013859 putative Mg++ binding site [ion binding]; other site 1166016013860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1166016013861 nucleotide binding region [chemical binding]; other site 1166016013862 ATP-binding site [chemical binding]; other site 1166016013863 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1166016013864 AsmA family; Region: AsmA; pfam05170 1166016013865 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1166016013866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1166016013867 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1166016013868 Coenzyme A binding pocket [chemical binding]; other site 1166016013869 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1166016013870 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1166016013871 putative active site [active] 1166016013872 dimerization interface [polypeptide binding]; other site 1166016013873 putative tRNAtyr binding site [nucleotide binding]; other site 1166016013874 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1166016013875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016013876 motif II; other site 1166016013877 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1166016013878 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1166016013879 G1 box; other site 1166016013880 putative GEF interaction site [polypeptide binding]; other site 1166016013881 GTP/Mg2+ binding site [chemical binding]; other site 1166016013882 Switch I region; other site 1166016013883 G2 box; other site 1166016013884 G3 box; other site 1166016013885 Switch II region; other site 1166016013886 G4 box; other site 1166016013887 G5 box; other site 1166016013888 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1166016013889 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1166016013890 glutamine synthetase; Provisional; Region: glnA; PRK09469 1166016013891 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1166016013892 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1166016013893 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1166016013894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016013895 dimer interface [polypeptide binding]; other site 1166016013896 phosphorylation site [posttranslational modification] 1166016013897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016013898 ATP binding site [chemical binding]; other site 1166016013899 Mg2+ binding site [ion binding]; other site 1166016013900 G-X-G motif; other site 1166016013901 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1166016013902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016013903 active site 1166016013904 phosphorylation site [posttranslational modification] 1166016013905 intermolecular recognition site; other site 1166016013906 dimerization interface [polypeptide binding]; other site 1166016013907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016013908 Walker A motif; other site 1166016013909 ATP binding site [chemical binding]; other site 1166016013910 Walker B motif; other site 1166016013911 arginine finger; other site 1166016013912 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1166016013913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1166016013914 catalytic loop [active] 1166016013915 iron binding site [ion binding]; other site 1166016013916 Transposase; Region: HTH_Tnp_1; cl17663 1166016013917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1166016013918 Integrase core domain; Region: rve_3; pfam13683 1166016013919 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1166016013920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1166016013921 FeS/SAM binding site; other site 1166016013922 HemN C-terminal domain; Region: HemN_C; pfam06969 1166016013923 Der GTPase activator; Provisional; Region: PRK05244 1166016013924 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1166016013925 G1 box; other site 1166016013926 GTP/Mg2+ binding site [chemical binding]; other site 1166016013927 Switch I region; other site 1166016013928 G2 box; other site 1166016013929 G3 box; other site 1166016013930 Switch II region; other site 1166016013931 G4 box; other site 1166016013932 G5 box; other site 1166016013933 DNA polymerase I; Provisional; Region: PRK05755 1166016013934 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1166016013935 active site 1166016013936 metal binding site 1 [ion binding]; metal-binding site 1166016013937 putative 5' ssDNA interaction site; other site 1166016013938 metal binding site 3; metal-binding site 1166016013939 metal binding site 2 [ion binding]; metal-binding site 1166016013940 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1166016013941 putative DNA binding site [nucleotide binding]; other site 1166016013942 putative metal binding site [ion binding]; other site 1166016013943 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1166016013944 active site 1166016013945 catalytic site [active] 1166016013946 substrate binding site [chemical binding]; other site 1166016013947 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1166016013948 active site 1166016013949 DNA binding site [nucleotide binding] 1166016013950 catalytic site [active] 1166016013951 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1166016013952 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1166016013953 catalytic residues [active] 1166016013954 hinge region; other site 1166016013955 alpha helical domain; other site 1166016013956 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1166016013957 serine/threonine protein kinase; Provisional; Region: PRK11768 1166016013958 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1166016013959 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1166016013960 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1166016013961 GTP binding site; other site 1166016013962 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1166016013963 Walker A motif; other site 1166016013964 transcriptional repressor RbsR; Provisional; Region: PRK10423 1166016013965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1166016013966 DNA binding site [nucleotide binding] 1166016013967 domain linker motif; other site 1166016013968 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1166016013969 dimerization interface [polypeptide binding]; other site 1166016013970 ligand binding site [chemical binding]; other site 1166016013971 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1166016013972 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1166016013973 substrate binding site [chemical binding]; other site 1166016013974 dimer interface [polypeptide binding]; other site 1166016013975 ATP binding site [chemical binding]; other site 1166016013976 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1166016013977 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1166016013978 ligand binding site [chemical binding]; other site 1166016013979 dimerization interface [polypeptide binding]; other site 1166016013980 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1166016013981 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1166016013982 TM-ABC transporter signature motif; other site 1166016013983 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1166016013984 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1166016013985 Walker A/P-loop; other site 1166016013986 ATP binding site [chemical binding]; other site 1166016013987 Q-loop/lid; other site 1166016013988 ABC transporter signature motif; other site 1166016013989 Walker B; other site 1166016013990 D-loop; other site 1166016013991 H-loop/switch region; other site 1166016013992 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1166016013993 D-ribose pyranase; Provisional; Region: PRK11797 1166016013994 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1166016013995 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1166016013996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1166016013997 active site 1166016013998 phosphorylation site [posttranslational modification] 1166016013999 intermolecular recognition site; other site 1166016014000 dimerization interface [polypeptide binding]; other site 1166016014001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1166016014002 DNA binding site [nucleotide binding] 1166016014003 sensor protein QseC; Provisional; Region: PRK10337 1166016014004 Gemmata obscuriglobus paralogous family TIGR03066; Region: Gem_osc_para_1 1166016014005 HAMP domain; Region: HAMP; pfam00672 1166016014006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1166016014007 dimer interface [polypeptide binding]; other site 1166016014008 phosphorylation site [posttranslational modification] 1166016014009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1166016014010 ATP binding site [chemical binding]; other site 1166016014011 Mg2+ binding site [ion binding]; other site 1166016014012 G-X-G motif; other site 1166016014013 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1166016014014 potassium uptake protein; Region: kup; TIGR00794 1166016014015 regulatory ATPase RavA; Provisional; Region: PRK13531 1166016014016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1166016014017 Walker A motif; other site 1166016014018 ATP binding site [chemical binding]; other site 1166016014019 Walker B motif; other site 1166016014020 arginine finger; other site 1166016014021 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1166016014022 hypothetical protein; Provisional; Region: yieM; PRK10997 1166016014023 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1166016014024 metal ion-dependent adhesion site (MIDAS); other site 1166016014025 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 1166016014026 motif 1; other site 1166016014027 dimer interface [polypeptide binding]; other site 1166016014028 active site 1166016014029 motif 2; other site 1166016014030 motif 3; other site 1166016014031 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1166016014032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1166016014033 putative DNA binding site [nucleotide binding]; other site 1166016014034 putative Zn2+ binding site [ion binding]; other site 1166016014035 AsnC family; Region: AsnC_trans_reg; pfam01037 1166016014036 FMN-binding protein MioC; Provisional; Region: PRK09004 1166016014037 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1166016014038 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1166016014039 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1166016014040 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1166016014041 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1166016014042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1166016014043 S-adenosylmethionine binding site [chemical binding]; other site 1166016014044 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1166016014045 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1166016014046 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1166016014047 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1166016014048 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1166016014049 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1166016014050 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1166016014051 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1166016014052 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1166016014053 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1166016014054 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1166016014055 beta subunit interaction interface [polypeptide binding]; other site 1166016014056 Walker A motif; other site 1166016014057 ATP binding site [chemical binding]; other site 1166016014058 Walker B motif; other site 1166016014059 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1166016014060 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1166016014061 core domain interface [polypeptide binding]; other site 1166016014062 delta subunit interface [polypeptide binding]; other site 1166016014063 epsilon subunit interface [polypeptide binding]; other site 1166016014064 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1166016014065 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1166016014066 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1166016014067 alpha subunit interaction interface [polypeptide binding]; other site 1166016014068 Walker A motif; other site 1166016014069 ATP binding site [chemical binding]; other site 1166016014070 Walker B motif; other site 1166016014071 inhibitor binding site; inhibition site 1166016014072 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1166016014073 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1166016014074 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1166016014075 gamma subunit interface [polypeptide binding]; other site 1166016014076 epsilon subunit interface [polypeptide binding]; other site 1166016014077 LBP interface [polypeptide binding]; other site 1166016014078 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1166016014079 imidazolonepropionase; Validated; Region: PRK09356 1166016014080 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1166016014081 active site 1166016014082 urocanate hydratase; Provisional; Region: PRK05414 1166016014083 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1166016014084 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1166016014085 Walker A/P-loop; other site 1166016014086 ATP binding site [chemical binding]; other site 1166016014087 Q-loop/lid; other site 1166016014088 ABC transporter signature motif; other site 1166016014089 Walker B; other site 1166016014090 D-loop; other site 1166016014091 H-loop/switch region; other site 1166016014092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016014093 dimer interface [polypeptide binding]; other site 1166016014094 conserved gate region; other site 1166016014095 ABC-ATPase subunit interface; other site 1166016014096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016014097 ABC-ATPase subunit interface; other site 1166016014098 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1166016014099 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1166016014100 active sites [active] 1166016014101 tetramer interface [polypeptide binding]; other site 1166016014102 HutD; Region: HutD; pfam05962 1166016014103 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1166016014104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1166016014105 DNA-binding site [nucleotide binding]; DNA binding site 1166016014106 UTRA domain; Region: UTRA; pfam07702 1166016014107 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1166016014108 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1166016014109 active site 1166016014110 Right handed beta helix region; Region: Beta_helix; pfam13229 1166016014111 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1166016014112 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1166016014113 Substrate binding site; other site 1166016014114 Mg++ binding site; other site 1166016014115 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1166016014116 active site 1166016014117 substrate binding site [chemical binding]; other site 1166016014118 CoA binding site [chemical binding]; other site 1166016014119 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1166016014120 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1166016014121 glutaminase active site [active] 1166016014122 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1166016014123 dimer interface [polypeptide binding]; other site 1166016014124 active site 1166016014125 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1166016014126 dimer interface [polypeptide binding]; other site 1166016014127 active site 1166016014128 O-methyltransferase; Region: Methyltransf_2; pfam00891 1166016014129 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1166016014130 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1166016014131 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1166016014132 putative acyl-acceptor binding pocket; other site 1166016014133 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1166016014134 acyl carrier protein; Provisional; Region: PRK05350 1166016014135 Predicted membrane protein [Function unknown]; Region: COG4648 1166016014136 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1166016014137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1166016014138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1166016014139 acyl-activating enzyme (AAE) consensus motif; other site 1166016014140 acyl-activating enzyme (AAE) consensus motif; other site 1166016014141 active site 1166016014142 AMP binding site [chemical binding]; other site 1166016014143 CoA binding site [chemical binding]; other site 1166016014144 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1166016014145 active site 2 [active] 1166016014146 dimer interface [polypeptide binding]; other site 1166016014147 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1166016014148 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1166016014149 Ligand binding site; other site 1166016014150 Putative Catalytic site; other site 1166016014151 DXD motif; other site 1166016014152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1166016014153 putative acyl-acceptor binding pocket; other site 1166016014154 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1166016014155 active site 1166016014156 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1166016014157 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1166016014158 Predicted exporter [General function prediction only]; Region: COG4258 1166016014159 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1166016014160 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1166016014161 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166016014162 dimer interface [polypeptide binding]; other site 1166016014163 active site 1166016014164 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1166016014165 putative active site 1 [active] 1166016014166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1166016014167 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1166016014168 NAD(P) binding site [chemical binding]; other site 1166016014169 active site 1166016014170 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1166016014171 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1166016014172 dimer interface [polypeptide binding]; other site 1166016014173 active site 1166016014174 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1166016014175 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1166016014176 active site 1166016014177 metal binding site [ion binding]; metal-binding site 1166016014178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016014179 substrate binding pocket [chemical binding]; other site 1166016014180 membrane-bound complex binding site; other site 1166016014181 hinge residues; other site 1166016014182 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1166016014183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016014184 dimer interface [polypeptide binding]; other site 1166016014185 conserved gate region; other site 1166016014186 putative PBP binding loops; other site 1166016014187 ABC-ATPase subunit interface; other site 1166016014188 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1166016014189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016014190 dimer interface [polypeptide binding]; other site 1166016014191 conserved gate region; other site 1166016014192 putative PBP binding loops; other site 1166016014193 ABC-ATPase subunit interface; other site 1166016014194 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1166016014195 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1166016014196 Walker A/P-loop; other site 1166016014197 ATP binding site [chemical binding]; other site 1166016014198 Q-loop/lid; other site 1166016014199 ABC transporter signature motif; other site 1166016014200 Walker B; other site 1166016014201 D-loop; other site 1166016014202 H-loop/switch region; other site 1166016014203 transcriptional regulator PhoU; Provisional; Region: PRK11115 1166016014204 PhoU domain; Region: PhoU; pfam01895 1166016014205 PhoU domain; Region: PhoU; pfam01895 1166016014206 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1166016014207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016014208 non-specific DNA binding site [nucleotide binding]; other site 1166016014209 salt bridge; other site 1166016014210 sequence-specific DNA binding site [nucleotide binding]; other site 1166016014211 Cupin domain; Region: Cupin_2; pfam07883 1166016014212 benzoate transporter; Region: benE; TIGR00843 1166016014213 Benzoate membrane transport protein; Region: BenE; pfam03594 1166016014214 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1166016014215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1166016014216 substrate binding pocket [chemical binding]; other site 1166016014217 membrane-bound complex binding site; other site 1166016014218 hinge residues; other site 1166016014219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016014220 dimer interface [polypeptide binding]; other site 1166016014221 conserved gate region; other site 1166016014222 putative PBP binding loops; other site 1166016014223 ABC-ATPase subunit interface; other site 1166016014224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1166016014225 dimer interface [polypeptide binding]; other site 1166016014226 conserved gate region; other site 1166016014227 putative PBP binding loops; other site 1166016014228 ABC-ATPase subunit interface; other site 1166016014229 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1166016014230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1166016014231 active site 1166016014232 motif I; other site 1166016014233 motif II; other site 1166016014234 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1166016014235 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1166016014236 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1166016014237 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1166016014238 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1166016014239 4Fe-4S binding domain; Region: Fer4; pfam00037 1166016014240 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1166016014241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1166016014242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1166016014243 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 1166016014244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1166016014245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 1166016014246 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1166016014247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1166016014248 putative substrate translocation pore; other site 1166016014249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1166016014250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1166016014251 metal binding site [ion binding]; metal-binding site 1166016014252 active site 1166016014253 I-site; other site 1166016014254 WYL domain; Region: WYL; pfam13280 1166016014255 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1166016014256 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1166016014257 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1166016014258 putative active site [active] 1166016014259 putative metal binding site [ion binding]; other site 1166016014260 N-glycosyltransferase; Provisional; Region: PRK11204 1166016014261 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1166016014262 DXD motif; other site 1166016014263 PgaD-like protein; Region: PgaD; pfam13994 1166016014264 Predicted transcriptional regulators [Transcription]; Region: COG1733 1166016014265 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1166016014266 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1166016014267 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1166016014268 NADP binding site [chemical binding]; other site 1166016014269 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1166016014270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1166016014271 non-specific DNA binding site [nucleotide binding]; other site 1166016014272 salt bridge; other site 1166016014273 sequence-specific DNA binding site [nucleotide binding]; other site 1166016014274 glutamine-tRNA ligase; Region: PLN02859 1166016014275 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1166016014276 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1166016014277 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1166016014278 G1 box; other site 1166016014279 GTP/Mg2+ binding site [chemical binding]; other site 1166016014280 Switch I region; other site 1166016014281 G2 box; other site 1166016014282 Switch II region; other site 1166016014283 G3 box; other site 1166016014284 G4 box; other site 1166016014285 G5 box; other site 1166016014286 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1166016014287 membrane protein insertase; Provisional; Region: PRK01318 1166016014288 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1166016014289 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399