-- dump date 20140619_231546 -- class Genbank::misc_feature -- table misc_feature_note -- id note 402881000001 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 402881000002 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 402881000003 active site residue [active] 402881000004 DnaA N-terminal domain; Region: DnaA_N; pfam11638 402881000005 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 402881000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881000007 Walker A motif; other site 402881000008 ATP binding site [chemical binding]; other site 402881000009 Walker B motif; other site 402881000010 arginine finger; other site 402881000011 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 402881000012 DnaA box-binding interface [nucleotide binding]; other site 402881000013 DNA polymerase III subunit beta; Validated; Region: PRK05643 402881000014 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 402881000015 putative DNA binding surface [nucleotide binding]; other site 402881000016 dimer interface [polypeptide binding]; other site 402881000017 beta-clamp/clamp loader binding surface; other site 402881000018 beta-clamp/translesion DNA polymerase binding surface; other site 402881000019 recombination protein F; Reviewed; Region: recF; PRK00064 402881000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881000021 Walker A/P-loop; other site 402881000022 ATP binding site [chemical binding]; other site 402881000023 Q-loop/lid; other site 402881000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881000025 ABC transporter signature motif; other site 402881000026 Walker B; other site 402881000027 D-loop; other site 402881000028 H-loop/switch region; other site 402881000029 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 402881000030 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 402881000031 oligomer interface [polypeptide binding]; other site 402881000032 active site residues [active] 402881000033 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 402881000034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881000035 Mg2+ binding site [ion binding]; other site 402881000036 G-X-G motif; other site 402881000037 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 402881000038 anchoring element; other site 402881000039 dimer interface [polypeptide binding]; other site 402881000040 ATP binding site [chemical binding]; other site 402881000041 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 402881000042 active site 402881000043 putative metal-binding site [ion binding]; other site 402881000044 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 402881000045 Transglycosylase; Region: Transgly; pfam00912 402881000046 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 402881000047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 402881000048 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 402881000049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881000050 putative substrate translocation pore; other site 402881000051 Protein of unknown function DUF45; Region: DUF45; pfam01863 402881000052 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 402881000053 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881000054 putative metal binding site [ion binding]; other site 402881000055 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 402881000056 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 402881000057 2-isopropylmalate synthase; Validated; Region: PRK03739 402881000058 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 402881000059 active site 402881000060 catalytic residues [active] 402881000061 metal binding site [ion binding]; metal-binding site 402881000062 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 402881000063 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 402881000064 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 402881000065 Cu(I) binding site [ion binding]; other site 402881000066 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 402881000067 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 402881000068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 402881000069 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 402881000070 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 402881000071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881000072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881000073 dimer interface [polypeptide binding]; other site 402881000074 phosphorylation site [posttranslational modification] 402881000075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881000076 ATP binding site [chemical binding]; other site 402881000077 Mg2+ binding site [ion binding]; other site 402881000078 G-X-G motif; other site 402881000079 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 402881000080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881000081 active site 402881000082 phosphorylation site [posttranslational modification] 402881000083 intermolecular recognition site; other site 402881000084 dimerization interface [polypeptide binding]; other site 402881000085 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 402881000086 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 402881000087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881000088 sequence-specific DNA binding site [nucleotide binding]; other site 402881000089 salt bridge; other site 402881000090 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 402881000091 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 402881000092 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 402881000093 active site 402881000094 ATP binding site [chemical binding]; other site 402881000095 Phosphotransferase enzyme family; Region: APH; pfam01636 402881000096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 402881000097 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 402881000098 dinuclear metal binding motif [ion binding]; other site 402881000099 putative chaperone; Provisional; Region: PRK11678 402881000100 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 402881000101 nucleotide binding site [chemical binding]; other site 402881000102 putative NEF/HSP70 interaction site [polypeptide binding]; other site 402881000103 SBD interface [polypeptide binding]; other site 402881000104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881000105 Cytochrome P450; Region: p450; cl12078 402881000106 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 402881000107 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 402881000108 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 402881000109 Cytochrome P450; Region: p450; cl12078 402881000110 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881000111 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 402881000112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881000113 motif I; other site 402881000114 motif II; other site 402881000115 Sporulation related domain; Region: SPOR; pfam05036 402881000116 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 402881000117 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881000118 P-loop; other site 402881000119 Magnesium ion binding site [ion binding]; other site 402881000120 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 402881000121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 402881000122 inhibitor-cofactor binding pocket; inhibition site 402881000123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881000124 catalytic residue [active] 402881000125 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 402881000126 GIY-YIG motif/motif A; other site 402881000127 biotin synthase; Region: bioB; TIGR00433 402881000128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881000129 FeS/SAM binding site; other site 402881000130 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 402881000131 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 402881000132 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 402881000133 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 402881000134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881000135 catalytic residue [active] 402881000136 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 402881000137 AAA domain; Region: AAA_26; pfam13500 402881000138 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 402881000139 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 402881000140 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 402881000141 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 402881000142 DNA binding site [nucleotide binding] 402881000143 active site 402881000144 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 402881000145 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 402881000146 AlkA N-terminal domain; Region: AlkA_N; pfam06029 402881000147 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 402881000148 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 402881000149 minor groove reading motif; other site 402881000150 helix-hairpin-helix signature motif; other site 402881000151 substrate binding pocket [chemical binding]; other site 402881000152 active site 402881000153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881000154 D-galactonate transporter; Region: 2A0114; TIGR00893 402881000155 putative substrate translocation pore; other site 402881000156 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 402881000157 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 402881000158 putative NAD(P) binding site [chemical binding]; other site 402881000159 putative substrate binding site [chemical binding]; other site 402881000160 catalytic Zn binding site [ion binding]; other site 402881000161 structural Zn binding site [ion binding]; other site 402881000162 PBP superfamily domain; Region: PBP_like_2; cl17296 402881000163 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 402881000164 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 402881000165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881000166 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 402881000167 PRC-barrel domain; Region: PRC; pfam05239 402881000168 HAMP domain; Region: HAMP; pfam00672 402881000169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 402881000170 Histidine kinase; Region: HisKA_2; pfam07568 402881000171 two-component response regulator; Provisional; Region: PRK09191 402881000172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 402881000173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881000174 active site 402881000175 phosphorylation site [posttranslational modification] 402881000176 intermolecular recognition site; other site 402881000177 dimerization interface [polypeptide binding]; other site 402881000178 RNA polymerase sigma factor; Provisional; Region: PRK12547 402881000179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881000180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881000181 DNA binding residues [nucleotide binding] 402881000182 CsbD-like; Region: CsbD; cl17424 402881000183 Entericidin EcnA/B family; Region: Entericidin; pfam08085 402881000184 MgtC family; Region: MgtC; pfam02308 402881000185 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 402881000186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 402881000187 MOSC domain; Region: MOSC; pfam03473 402881000188 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 402881000189 Response regulator receiver domain; Region: Response_reg; pfam00072 402881000190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881000191 active site 402881000192 phosphorylation site [posttranslational modification] 402881000193 intermolecular recognition site; other site 402881000194 dimerization interface [polypeptide binding]; other site 402881000195 Response regulator receiver domain; Region: Response_reg; pfam00072 402881000196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881000197 active site 402881000198 phosphorylation site [posttranslational modification] 402881000199 intermolecular recognition site; other site 402881000200 dimerization interface [polypeptide binding]; other site 402881000201 Predicted membrane protein [Function unknown]; Region: COG4655 402881000202 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 402881000203 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 402881000204 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 402881000205 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 402881000206 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 402881000207 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 402881000208 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 402881000209 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 402881000210 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 402881000211 Response regulator receiver domain; Region: Response_reg; pfam00072 402881000212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 402881000213 active site 402881000214 phosphorylation site [posttranslational modification] 402881000215 intermolecular recognition site; other site 402881000216 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 402881000217 dimerization interface [polypeptide binding]; other site 402881000218 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 402881000219 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 402881000220 ATP binding site [chemical binding]; other site 402881000221 Walker A motif; other site 402881000222 hexamer interface [polypeptide binding]; other site 402881000223 Walker B motif; other site 402881000224 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 402881000225 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 402881000226 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 402881000227 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 402881000228 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 402881000229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 402881000230 binding surface 402881000231 TPR motif; other site 402881000232 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 402881000233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881000234 dimer interface [polypeptide binding]; other site 402881000235 phosphorylation site [posttranslational modification] 402881000236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881000237 ATP binding site [chemical binding]; other site 402881000238 Mg2+ binding site [ion binding]; other site 402881000239 G-X-G motif; other site 402881000240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881000241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881000242 active site 402881000243 phosphorylation site [posttranslational modification] 402881000244 intermolecular recognition site; other site 402881000245 dimerization interface [polypeptide binding]; other site 402881000246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881000247 DNA binding site [nucleotide binding] 402881000248 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881000249 Cytochrome P450; Region: p450; cl12078 402881000250 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 402881000251 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 402881000252 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 402881000253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 402881000254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881000255 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 402881000256 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 402881000257 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 402881000258 catalytic Zn binding site [ion binding]; other site 402881000259 NAD binding site [chemical binding]; other site 402881000260 structural Zn binding site [ion binding]; other site 402881000261 acetyl-CoA acetyltransferase; Provisional; Region: PRK06025 402881000262 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881000263 dimer interface [polypeptide binding]; other site 402881000264 active site 402881000265 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 402881000266 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 402881000267 DNA binding residues [nucleotide binding] 402881000268 putative dimer interface [polypeptide binding]; other site 402881000269 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881000270 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 402881000271 NAD(P) binding site [chemical binding]; other site 402881000272 catalytic residues [active] 402881000273 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 402881000274 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 402881000275 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 402881000276 FAD binding pocket [chemical binding]; other site 402881000277 FAD binding motif [chemical binding]; other site 402881000278 phosphate binding motif [ion binding]; other site 402881000279 beta-alpha-beta structure motif; other site 402881000280 NAD binding pocket [chemical binding]; other site 402881000281 Protein of unknown function (DUF454); Region: DUF454; cl01063 402881000282 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 402881000283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881000284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881000285 homodimer interface [polypeptide binding]; other site 402881000286 catalytic residue [active] 402881000287 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 402881000288 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 402881000289 TrkA-C domain; Region: TrkA_C; pfam02080 402881000290 TrkA-C domain; Region: TrkA_C; pfam02080 402881000291 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 402881000292 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 402881000293 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 402881000294 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 402881000295 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 402881000296 Replication initiation factor; Region: Rep_trans; pfam02486 402881000297 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 402881000298 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 402881000299 catalytic residues [active] 402881000300 catalytic nucleophile [active] 402881000301 Recombinase; Region: Recombinase; pfam07508 402881000302 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 402881000303 PAS domain; Region: PAS_5; pfam07310 402881000304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881000305 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 402881000306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881000307 Walker A/P-loop; other site 402881000308 ATP binding site [chemical binding]; other site 402881000309 Q-loop/lid; other site 402881000310 ABC transporter signature motif; other site 402881000311 Walker B; other site 402881000312 D-loop; other site 402881000313 H-loop/switch region; other site 402881000314 DNA polymerase I; Provisional; Region: PRK05755 402881000315 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 402881000316 active site 402881000317 metal binding site 1 [ion binding]; metal-binding site 402881000318 putative 5' ssDNA interaction site; other site 402881000319 metal binding site 3; metal-binding site 402881000320 metal binding site 2 [ion binding]; metal-binding site 402881000321 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 402881000322 putative DNA binding site [nucleotide binding]; other site 402881000323 putative metal binding site [ion binding]; other site 402881000324 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 402881000325 active site 402881000326 catalytic site [active] 402881000327 substrate binding site [chemical binding]; other site 402881000328 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 402881000329 active site 402881000330 DNA binding site [nucleotide binding] 402881000331 catalytic site [active] 402881000332 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 402881000333 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881000334 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 402881000335 putative N-terminal domain interface [polypeptide binding]; other site 402881000336 Predicted transcriptional regulator [Transcription]; Region: COG2378 402881000337 HTH domain; Region: HTH_11; pfam08279 402881000338 WYL domain; Region: WYL; pfam13280 402881000339 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 402881000340 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 402881000341 active site 402881000342 substrate-binding site [chemical binding]; other site 402881000343 metal-binding site [ion binding] 402881000344 ATP binding site [chemical binding]; other site 402881000345 hypothetical protein; Provisional; Region: PRK08262 402881000346 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 402881000347 metal binding site [ion binding]; metal-binding site 402881000348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881000349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881000350 active site 402881000351 phosphorylation site [posttranslational modification] 402881000352 intermolecular recognition site; other site 402881000353 dimerization interface [polypeptide binding]; other site 402881000354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881000355 DNA binding site [nucleotide binding] 402881000356 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 402881000357 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 402881000358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881000359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 402881000360 dimerization interface [polypeptide binding]; other site 402881000361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881000362 dimer interface [polypeptide binding]; other site 402881000363 phosphorylation site [posttranslational modification] 402881000364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881000365 ATP binding site [chemical binding]; other site 402881000366 Mg2+ binding site [ion binding]; other site 402881000367 G-X-G motif; other site 402881000368 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 402881000369 Hpr binding site; other site 402881000370 active site 402881000371 homohexamer subunit interaction site [polypeptide binding]; other site 402881000372 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 402881000373 active pocket/dimerization site; other site 402881000374 active site 402881000375 phosphorylation site [posttranslational modification] 402881000376 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 402881000377 dimerization domain swap beta strand [polypeptide binding]; other site 402881000378 regulatory protein interface [polypeptide binding]; other site 402881000379 active site 402881000380 regulatory phosphorylation site [posttranslational modification]; other site 402881000381 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 402881000382 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 402881000383 active site 2 [active] 402881000384 active site 1 [active] 402881000385 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 402881000386 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 402881000387 homotetramer interface [polypeptide binding]; other site 402881000388 ligand binding site [chemical binding]; other site 402881000389 catalytic site [active] 402881000390 NAD binding site [chemical binding]; other site 402881000391 PAS fold; Region: PAS_7; pfam12860 402881000392 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 402881000393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881000394 dimer interface [polypeptide binding]; other site 402881000395 phosphorylation site [posttranslational modification] 402881000396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881000397 ATP binding site [chemical binding]; other site 402881000398 Mg2+ binding site [ion binding]; other site 402881000399 G-X-G motif; other site 402881000400 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 402881000401 glutathione s-transferase; Provisional; Region: PTZ00057 402881000402 GSH binding site (G-site) [chemical binding]; other site 402881000403 C-terminal domain interface [polypeptide binding]; other site 402881000404 dimer interface [polypeptide binding]; other site 402881000405 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 402881000406 dimer interface [polypeptide binding]; other site 402881000407 N-terminal domain interface [polypeptide binding]; other site 402881000408 substrate binding pocket (H-site) [chemical binding]; other site 402881000409 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 402881000410 E-class dimer interface [polypeptide binding]; other site 402881000411 P-class dimer interface [polypeptide binding]; other site 402881000412 active site 402881000413 Cu2+ binding site [ion binding]; other site 402881000414 Zn2+ binding site [ion binding]; other site 402881000415 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 402881000416 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881000417 catalytic loop [active] 402881000418 iron binding site [ion binding]; other site 402881000419 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 402881000420 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 402881000421 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 402881000422 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 402881000423 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 402881000424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881000425 catalytic loop [active] 402881000426 iron binding site [ion binding]; other site 402881000427 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 402881000428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881000429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881000430 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 402881000431 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881000432 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 402881000433 putative NAD(P) binding site [chemical binding]; other site 402881000434 putative active site [active] 402881000435 hypothetical protein; Provisional; Region: PRK06126 402881000436 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881000437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881000438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881000439 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 402881000440 Uncharacterized conserved protein [Function unknown]; Region: COG2128 402881000441 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 402881000442 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 402881000443 Phosphotransferase enzyme family; Region: APH; pfam01636 402881000444 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 402881000445 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 402881000446 Substrate binding site; other site 402881000447 metal-binding site 402881000448 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 402881000449 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 402881000450 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 402881000451 Family description; Region: UvrD_C_2; pfam13538 402881000452 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 402881000453 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 402881000454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 402881000455 catalytic residues [active] 402881000456 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 402881000457 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 402881000458 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 402881000459 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 402881000460 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 402881000461 substrate binding site [chemical binding]; other site 402881000462 active site 402881000463 catalytic residues [active] 402881000464 heterodimer interface [polypeptide binding]; other site 402881000465 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 402881000466 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 402881000467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881000468 catalytic residue [active] 402881000469 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 402881000470 active site 402881000471 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 402881000472 active site 402881000473 dimer interface [polypeptide binding]; other site 402881000474 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 402881000475 IHF dimer interface [polypeptide binding]; other site 402881000476 IHF - DNA interface [nucleotide binding]; other site 402881000477 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 402881000478 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 402881000479 tandem repeat interface [polypeptide binding]; other site 402881000480 oligomer interface [polypeptide binding]; other site 402881000481 active site residues [active] 402881000482 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 402881000483 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 402881000484 RNA binding site [nucleotide binding]; other site 402881000485 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 402881000486 RNA binding site [nucleotide binding]; other site 402881000487 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 402881000488 RNA binding site [nucleotide binding]; other site 402881000489 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 402881000490 RNA binding site [nucleotide binding]; other site 402881000491 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 402881000492 RNA binding site [nucleotide binding]; other site 402881000493 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 402881000494 RNA binding site [nucleotide binding]; other site 402881000495 cytidylate kinase; Provisional; Region: cmk; PRK00023 402881000496 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 402881000497 CMP-binding site; other site 402881000498 The sites determining sugar specificity; other site 402881000499 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 402881000500 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 402881000501 hinge; other site 402881000502 active site 402881000503 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 402881000504 TIGR02300 family protein; Region: FYDLN_acid 402881000505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881000506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881000507 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 402881000508 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881000509 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881000510 acyl-activating enzyme (AAE) consensus motif; other site 402881000511 putative AMP binding site [chemical binding]; other site 402881000512 putative active site [active] 402881000513 putative CoA binding site [chemical binding]; other site 402881000514 lipid-transfer protein; Provisional; Region: PRK08256 402881000515 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 402881000516 active site 402881000517 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 402881000518 active site 402881000519 catalytic site [active] 402881000520 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 402881000521 active site 402881000522 catalytic site [active] 402881000523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 402881000524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881000525 NAD(P) binding site [chemical binding]; other site 402881000526 active site 402881000527 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 402881000528 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 402881000529 [2Fe-2S] cluster binding site [ion binding]; other site 402881000530 C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883 402881000531 putative alpha subunit interface [polypeptide binding]; other site 402881000532 putative active site [active] 402881000533 putative substrate binding site [chemical binding]; other site 402881000534 Fe binding site [ion binding]; other site 402881000535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881000536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881000537 DNA binding residues [nucleotide binding] 402881000538 dimerization interface [polypeptide binding]; other site 402881000539 hypothetical protein; Provisional; Region: PRK07036 402881000540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 402881000541 inhibitor-cofactor binding pocket; inhibition site 402881000542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881000543 catalytic residue [active] 402881000544 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 402881000545 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 402881000546 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 402881000547 Amidase; Region: Amidase; cl11426 402881000548 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 402881000549 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881000550 NAD binding site [chemical binding]; other site 402881000551 catalytic residues [active] 402881000552 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 402881000553 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 402881000554 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 402881000555 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 402881000556 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 402881000557 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881000558 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881000559 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881000560 Predicted transcriptional regulators [Transcription]; Region: COG1695 402881000561 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 402881000562 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 402881000563 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 402881000564 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 402881000565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881000566 active site 402881000567 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 402881000568 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 402881000569 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881000570 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 402881000571 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881000572 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 402881000573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881000574 dimer interface [polypeptide binding]; other site 402881000575 conserved gate region; other site 402881000576 putative PBP binding loops; other site 402881000577 ABC-ATPase subunit interface; other site 402881000578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881000579 dimer interface [polypeptide binding]; other site 402881000580 conserved gate region; other site 402881000581 putative PBP binding loops; other site 402881000582 ABC-ATPase subunit interface; other site 402881000583 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 402881000584 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 402881000585 Walker A/P-loop; other site 402881000586 ATP binding site [chemical binding]; other site 402881000587 Q-loop/lid; other site 402881000588 ABC transporter signature motif; other site 402881000589 Walker B; other site 402881000590 D-loop; other site 402881000591 H-loop/switch region; other site 402881000592 TOBE domain; Region: TOBE_2; pfam08402 402881000593 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 402881000594 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 402881000595 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 402881000596 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 402881000597 Walker A/P-loop; other site 402881000598 ATP binding site [chemical binding]; other site 402881000599 Q-loop/lid; other site 402881000600 ABC transporter signature motif; other site 402881000601 Walker B; other site 402881000602 D-loop; other site 402881000603 H-loop/switch region; other site 402881000604 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 402881000605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 402881000606 ABC-ATPase subunit interface; other site 402881000607 dimer interface [polypeptide binding]; other site 402881000608 putative PBP binding regions; other site 402881000609 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 402881000610 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 402881000611 putative hemin binding site; other site 402881000612 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 402881000613 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 402881000614 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 402881000615 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 402881000616 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 402881000617 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 402881000618 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881000619 N-terminal plug; other site 402881000620 ligand-binding site [chemical binding]; other site 402881000621 Hemin uptake protein hemP; Region: hemP; pfam10636 402881000622 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 402881000623 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 402881000624 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 402881000625 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 402881000626 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 402881000627 putative dimer interface [polypeptide binding]; other site 402881000628 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 402881000629 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 402881000630 active site 402881000631 phosphorylation site [posttranslational modification] 402881000632 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 402881000633 30S subunit binding site; other site 402881000634 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 402881000635 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 402881000636 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 402881000637 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 402881000638 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 402881000639 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 402881000640 Walker A/P-loop; other site 402881000641 ATP binding site [chemical binding]; other site 402881000642 Q-loop/lid; other site 402881000643 ABC transporter signature motif; other site 402881000644 Walker B; other site 402881000645 D-loop; other site 402881000646 H-loop/switch region; other site 402881000647 OstA-like protein; Region: OstA; pfam03968 402881000648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 402881000649 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 402881000650 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 402881000651 catalytic site [active] 402881000652 putative active site [active] 402881000653 putative substrate binding site [chemical binding]; other site 402881000654 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 402881000655 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 402881000656 putative NAD(P) binding site [chemical binding]; other site 402881000657 active site 402881000658 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 402881000659 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 402881000660 DNA binding residues [nucleotide binding] 402881000661 dimer interface [polypeptide binding]; other site 402881000662 copper binding site [ion binding]; other site 402881000663 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881000664 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881000665 C-terminal domain interface [polypeptide binding]; other site 402881000666 GSH binding site (G-site) [chemical binding]; other site 402881000667 dimer interface [polypeptide binding]; other site 402881000668 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 402881000669 N-terminal domain interface [polypeptide binding]; other site 402881000670 dimer interface [polypeptide binding]; other site 402881000671 substrate binding pocket (H-site) [chemical binding]; other site 402881000672 epoxyqueuosine reductase; Region: TIGR00276 402881000673 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 402881000674 TPR repeat; Region: TPR_11; pfam13414 402881000675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881000676 TPR motif; other site 402881000677 binding surface 402881000678 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 402881000679 putative NAD(P) binding site [chemical binding]; other site 402881000680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 402881000681 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881000682 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881000683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881000684 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 402881000685 putative ADP-binding pocket [chemical binding]; other site 402881000686 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 402881000687 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 402881000688 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 402881000689 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 402881000690 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 402881000691 active site 402881000692 catalytic site [active] 402881000693 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 402881000694 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 402881000695 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881000696 MarR family; Region: MarR_2; pfam12802 402881000697 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 402881000698 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 402881000699 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 402881000700 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 402881000701 dimer interface [polypeptide binding]; other site 402881000702 substrate binding site [chemical binding]; other site 402881000703 metal binding site [ion binding]; metal-binding site 402881000704 CcdB protein; Region: CcdB; cl03380 402881000705 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 402881000706 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 402881000707 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 402881000708 23S rRNA binding site [nucleotide binding]; other site 402881000709 L21 binding site [polypeptide binding]; other site 402881000710 L13 binding site [polypeptide binding]; other site 402881000711 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 402881000712 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 402881000713 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 402881000714 dimer interface [polypeptide binding]; other site 402881000715 motif 1; other site 402881000716 active site 402881000717 motif 2; other site 402881000718 motif 3; other site 402881000719 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 402881000720 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 402881000721 putative tRNA-binding site [nucleotide binding]; other site 402881000722 B3/4 domain; Region: B3_4; pfam03483 402881000723 tRNA synthetase B5 domain; Region: B5; smart00874 402881000724 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 402881000725 dimer interface [polypeptide binding]; other site 402881000726 motif 1; other site 402881000727 motif 3; other site 402881000728 motif 2; other site 402881000729 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 402881000730 enoyl-CoA hydratase; Provisional; Region: PRK06210 402881000731 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881000732 substrate binding site [chemical binding]; other site 402881000733 oxyanion hole (OAH) forming residues; other site 402881000734 trimer interface [polypeptide binding]; other site 402881000735 GTP-binding protein LepA; Provisional; Region: PRK05433 402881000736 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 402881000737 G1 box; other site 402881000738 putative GEF interaction site [polypeptide binding]; other site 402881000739 GTP/Mg2+ binding site [chemical binding]; other site 402881000740 Switch I region; other site 402881000741 G2 box; other site 402881000742 G3 box; other site 402881000743 Switch II region; other site 402881000744 G4 box; other site 402881000745 G5 box; other site 402881000746 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 402881000747 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 402881000748 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 402881000749 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 402881000750 TadE-like protein; Region: TadE; pfam07811 402881000751 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 402881000752 TadE-like protein; Region: TadE; pfam07811 402881000753 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 402881000754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 402881000755 von Willebrand factor type A domain; Region: VWA_2; pfam13519 402881000756 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 402881000757 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 402881000758 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 402881000759 ligand binding site [chemical binding]; other site 402881000760 flexible hinge region; other site 402881000761 Flp/Fap pilin component; Region: Flp_Fap; cl01585 402881000762 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 402881000763 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 402881000764 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 402881000765 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 402881000766 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 402881000767 BON domain; Region: BON; pfam04972 402881000768 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 402881000769 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 402881000770 Type IV pili component [Cell motility and secretion]; Region: COG5461 402881000771 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 402881000772 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 402881000773 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 402881000774 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 402881000775 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 402881000776 ATP binding site [chemical binding]; other site 402881000777 Walker A motif; other site 402881000778 hexamer interface [polypeptide binding]; other site 402881000779 Walker B motif; other site 402881000780 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 402881000781 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 402881000782 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 402881000783 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 402881000784 TPR repeat; Region: TPR_11; pfam13414 402881000785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881000786 TPR motif; other site 402881000787 binding surface 402881000788 Tetratricopeptide repeat; Region: TPR_16; pfam13432 402881000789 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 402881000790 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 402881000791 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 402881000792 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881000793 putative C-terminal domain interface [polypeptide binding]; other site 402881000794 putative GSH binding site (G-site) [chemical binding]; other site 402881000795 putative dimer interface [polypeptide binding]; other site 402881000796 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 402881000797 putative N-terminal domain interface [polypeptide binding]; other site 402881000798 putative dimer interface [polypeptide binding]; other site 402881000799 putative substrate binding pocket (H-site) [chemical binding]; other site 402881000800 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 402881000801 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 402881000802 interface (dimer of trimers) [polypeptide binding]; other site 402881000803 Substrate-binding/catalytic site; other site 402881000804 Zn-binding sites [ion binding]; other site 402881000805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881000806 MarR family; Region: MarR; pfam01047 402881000807 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 402881000808 NlpC/P60 family; Region: NLPC_P60; pfam00877 402881000809 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 402881000810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 402881000811 Walker A/P-loop; other site 402881000812 ATP binding site [chemical binding]; other site 402881000813 Q-loop/lid; other site 402881000814 ABC transporter signature motif; other site 402881000815 Walker B; other site 402881000816 D-loop; other site 402881000817 H-loop/switch region; other site 402881000818 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 402881000819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 402881000820 Walker A/P-loop; other site 402881000821 ATP binding site [chemical binding]; other site 402881000822 Q-loop/lid; other site 402881000823 ABC transporter signature motif; other site 402881000824 Walker B; other site 402881000825 D-loop; other site 402881000826 H-loop/switch region; other site 402881000827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 402881000828 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 402881000829 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 402881000830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881000831 dimer interface [polypeptide binding]; other site 402881000832 conserved gate region; other site 402881000833 ABC-ATPase subunit interface; other site 402881000834 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 402881000835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881000836 dimer interface [polypeptide binding]; other site 402881000837 conserved gate region; other site 402881000838 ABC-ATPase subunit interface; other site 402881000839 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 402881000840 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 402881000841 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 402881000842 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 402881000843 Cytochrome c2 [Energy production and conversion]; Region: COG3474 402881000844 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 402881000845 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 402881000846 Ligand binding site; other site 402881000847 oligomer interface; other site 402881000848 prephenate dehydratase; Provisional; Region: PRK11899 402881000849 Prephenate dehydratase; Region: PDT; pfam00800 402881000850 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 402881000851 putative L-Phe binding site [chemical binding]; other site 402881000852 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 402881000853 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 402881000854 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 402881000855 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 402881000856 putative NADH binding site [chemical binding]; other site 402881000857 putative active site [active] 402881000858 nudix motif; other site 402881000859 putative metal binding site [ion binding]; other site 402881000860 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 402881000861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881000862 Walker A motif; other site 402881000863 ATP binding site [chemical binding]; other site 402881000864 Walker B motif; other site 402881000865 arginine finger; other site 402881000866 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 402881000867 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 402881000868 hypothetical protein; Validated; Region: PRK00153 402881000869 recombination protein RecR; Reviewed; Region: recR; PRK00076 402881000870 RecR protein; Region: RecR; pfam02132 402881000871 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 402881000872 putative active site [active] 402881000873 putative metal-binding site [ion binding]; other site 402881000874 tetramer interface [polypeptide binding]; other site 402881000875 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 402881000876 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 402881000877 RmuC family; Region: RmuC; pfam02646 402881000878 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 402881000879 active site 402881000880 catalytic residues [active] 402881000881 metal binding site [ion binding]; metal-binding site 402881000882 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 402881000883 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 402881000884 putative active site [active] 402881000885 substrate binding site [chemical binding]; other site 402881000886 putative cosubstrate binding site; other site 402881000887 catalytic site [active] 402881000888 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 402881000889 substrate binding site [chemical binding]; other site 402881000890 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 402881000891 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 402881000892 dimerization interface 3.5A [polypeptide binding]; other site 402881000893 active site 402881000894 glutamate racemase; Provisional; Region: PRK00865 402881000895 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 402881000896 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 402881000897 metal binding site [ion binding]; metal-binding site 402881000898 dimer interface [polypeptide binding]; other site 402881000899 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 402881000900 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 402881000901 trimer interface [polypeptide binding]; other site 402881000902 active site 402881000903 substrate binding site [chemical binding]; other site 402881000904 CoA binding site [chemical binding]; other site 402881000905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 402881000906 Peptidase family C69; Region: Peptidase_C69; cl17793 402881000907 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 402881000908 catalytic residues [active] 402881000909 dimer interface [polypeptide binding]; other site 402881000910 DinB family; Region: DinB; cl17821 402881000911 DinB superfamily; Region: DinB_2; pfam12867 402881000912 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 402881000913 ligand binding site [chemical binding]; other site 402881000914 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 402881000915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881000916 NAD(P) binding site [chemical binding]; other site 402881000917 active site 402881000918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881000919 Coenzyme A binding pocket [chemical binding]; other site 402881000920 short chain dehydrogenase; Validated; Region: PRK06182 402881000921 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 402881000922 NADP binding site [chemical binding]; other site 402881000923 active site 402881000924 steroid binding site; other site 402881000925 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881000926 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 402881000927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881000928 non-specific DNA binding site [nucleotide binding]; other site 402881000929 salt bridge; other site 402881000930 sequence-specific DNA binding site [nucleotide binding]; other site 402881000931 Cupin domain; Region: Cupin_2; pfam07883 402881000932 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 402881000933 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 402881000934 inhibitor-cofactor binding pocket; inhibition site 402881000935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881000936 catalytic residue [active] 402881000937 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 402881000938 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881000939 Zn binding site [ion binding]; other site 402881000940 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 402881000941 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 402881000942 MarR family; Region: MarR_2; pfam12802 402881000943 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 402881000944 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 402881000945 tetramer interface [polypeptide binding]; other site 402881000946 active site 402881000947 Mg2+/Mn2+ binding site [ion binding]; other site 402881000948 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881000949 CoenzymeA binding site [chemical binding]; other site 402881000950 subunit interaction site [polypeptide binding]; other site 402881000951 PHB binding site; other site 402881000952 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 402881000953 GIY-YIG motif/motif A; other site 402881000954 putative active site [active] 402881000955 putative metal binding site [ion binding]; other site 402881000956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 402881000957 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 402881000958 substrate binding pocket [chemical binding]; other site 402881000959 membrane-bound complex binding site; other site 402881000960 hinge residues; other site 402881000961 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 402881000962 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 402881000963 active site 402881000964 HIGH motif; other site 402881000965 nucleotide binding site [chemical binding]; other site 402881000966 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 402881000967 active site 402881000968 KMSKS motif; other site 402881000969 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 402881000970 tRNA binding surface [nucleotide binding]; other site 402881000971 anticodon binding site; other site 402881000972 lipoprotein signal peptidase; Provisional; Region: PRK14796 402881000973 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 402881000974 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 402881000975 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 402881000976 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 402881000977 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 402881000978 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 402881000979 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 402881000980 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 402881000981 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 402881000982 dimer interface [polypeptide binding]; other site 402881000983 active site 402881000984 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 402881000985 dimer interface [polypeptide binding]; other site 402881000986 active site 402881000987 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 402881000988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881000989 Mg2+ binding site [ion binding]; other site 402881000990 G-X-G motif; other site 402881000991 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 402881000992 ATP binding site [chemical binding]; other site 402881000993 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 402881000994 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 402881000995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881000996 motif II; other site 402881000997 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 402881000998 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 402881000999 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 402881001000 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 402881001001 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 402881001002 feedback inhibition sensing region; other site 402881001003 homohexameric interface [polypeptide binding]; other site 402881001004 nucleotide binding site [chemical binding]; other site 402881001005 N-acetyl-L-glutamate binding site [chemical binding]; other site 402881001006 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 402881001007 G1 box; other site 402881001008 GTP/Mg2+ binding site [chemical binding]; other site 402881001009 Switch I region; other site 402881001010 G2 box; other site 402881001011 G3 box; other site 402881001012 Switch II region; other site 402881001013 G4 box; other site 402881001014 G5 box; other site 402881001015 membrane protein insertase; Provisional; Region: PRK01318 402881001016 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 402881001017 Ribonuclease P; Region: Ribonuclease_P; cl00457 402881001018 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 402881001019 Protein of unknown function, DUF547; Region: DUF547; pfam04784 402881001020 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 402881001021 mercuric reductase; Validated; Region: PRK06370 402881001022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881001023 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 402881001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881001025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881001026 ATP binding site [chemical binding]; other site 402881001027 Mg2+ binding site [ion binding]; other site 402881001028 G-X-G motif; other site 402881001029 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 402881001030 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 402881001031 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 402881001032 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 402881001033 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 402881001034 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 402881001035 active site 402881001036 homotetramer interface [polypeptide binding]; other site 402881001037 Glucokinase; Region: Glucokinase; cl17310 402881001038 glucokinase, proteobacterial type; Region: glk; TIGR00749 402881001039 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 402881001040 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 402881001041 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 402881001042 putative active site pocket [active] 402881001043 cleavage site 402881001044 Fic/DOC family; Region: Fic; cl00960 402881001045 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 402881001046 AAA-like domain; Region: AAA_10; pfam12846 402881001047 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 402881001048 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 402881001049 ParB-like nuclease domain; Region: ParBc; pfam02195 402881001050 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 402881001051 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 402881001052 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 402881001053 ATP binding site [chemical binding]; other site 402881001054 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 402881001055 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 402881001056 catalytic residues [active] 402881001057 catalytic nucleophile [active] 402881001058 Recombinase; Region: Recombinase; pfam07508 402881001059 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 402881001060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881001061 non-specific DNA binding site [nucleotide binding]; other site 402881001062 salt bridge; other site 402881001063 sequence-specific DNA binding site [nucleotide binding]; other site 402881001064 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 402881001065 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 402881001066 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 402881001067 catalytic core [active] 402881001068 Methyltransferase domain; Region: Methyltransf_24; pfam13578 402881001069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881001070 active site 402881001071 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 402881001072 active site 402881001073 catalytic residues [active] 402881001074 DNA binding site [nucleotide binding] 402881001075 Int/Topo IB signature motif; other site 402881001076 FRG domain; Region: FRG; pfam08867 402881001077 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 402881001078 Ligand Binding Site [chemical binding]; other site 402881001079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 402881001080 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 402881001081 ATP binding site [chemical binding]; other site 402881001082 substrate binding site [chemical binding]; other site 402881001083 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 402881001084 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 402881001085 helix-hairpin-helix signature motif; other site 402881001086 active site 402881001087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881001088 non-specific DNA binding site [nucleotide binding]; other site 402881001089 salt bridge; other site 402881001090 sequence-specific DNA binding site [nucleotide binding]; other site 402881001091 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 402881001092 AAA-like domain; Region: AAA_10; pfam12846 402881001093 Replication-relaxation; Region: Replic_Relax; pfam13814 402881001094 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 402881001095 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 402881001096 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 402881001097 Multicopper oxidase; Region: Cu-oxidase; pfam00394 402881001098 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 402881001099 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 402881001100 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 402881001101 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 402881001102 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881001103 Soluble P-type ATPase [General function prediction only]; Region: COG4087 402881001104 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 402881001105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881001106 Beta-Casp domain; Region: Beta-Casp; smart01027 402881001107 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 402881001108 YtkA-like; Region: YtkA; pfam13115 402881001109 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881001110 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881001111 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 402881001112 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 402881001113 active site residue [active] 402881001114 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 402881001115 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 402881001116 active site 402881001117 DNA binding site [nucleotide binding] 402881001118 Int/Topo IB signature motif; other site 402881001119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881001120 PAS domain; Region: PAS_9; pfam13426 402881001121 putative active site [active] 402881001122 heme pocket [chemical binding]; other site 402881001123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881001124 PAS domain; Region: PAS_9; pfam13426 402881001125 putative active site [active] 402881001126 heme pocket [chemical binding]; other site 402881001127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 402881001128 HWE histidine kinase; Region: HWE_HK; smart00911 402881001129 Response regulator receiver domain; Region: Response_reg; pfam00072 402881001130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881001131 active site 402881001132 phosphorylation site [posttranslational modification] 402881001133 intermolecular recognition site; other site 402881001134 dimerization interface [polypeptide binding]; other site 402881001135 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881001136 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 402881001137 dimer interface [polypeptide binding]; other site 402881001138 active site 402881001139 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881001140 Sulfatase; Region: Sulfatase; pfam00884 402881001141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881001142 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 402881001143 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881001144 FMN binding site [chemical binding]; other site 402881001145 substrate binding site [chemical binding]; other site 402881001146 putative catalytic residue [active] 402881001147 enoyl-CoA hydratase; Provisional; Region: PRK07509 402881001148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881001149 substrate binding site [chemical binding]; other site 402881001150 oxyanion hole (OAH) forming residues; other site 402881001151 trimer interface [polypeptide binding]; other site 402881001152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 402881001153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881001154 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881001155 Ecdysteroid kinase; Region: EcKinase; cl17738 402881001156 Phosphotransferase enzyme family; Region: APH; pfam01636 402881001157 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881001158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881001159 FAD binding domain; Region: FAD_binding_3; pfam01494 402881001160 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881001161 Phosphotransferase enzyme family; Region: APH; pfam01636 402881001162 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 402881001163 putative active site [active] 402881001164 putative substrate binding site [chemical binding]; other site 402881001165 ATP binding site [chemical binding]; other site 402881001166 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 402881001167 classical (c) SDRs; Region: SDR_c; cd05233 402881001168 NAD(P) binding site [chemical binding]; other site 402881001169 active site 402881001170 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 402881001171 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 402881001172 catalytic Zn binding site [ion binding]; other site 402881001173 NAD(P) binding site [chemical binding]; other site 402881001174 structural Zn binding site [ion binding]; other site 402881001175 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 402881001176 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 402881001177 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 402881001178 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 402881001179 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 402881001180 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881001181 N-terminal plug; other site 402881001182 ligand-binding site [chemical binding]; other site 402881001183 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 402881001184 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 402881001185 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 402881001186 active site 402881001187 substrate binding site [chemical binding]; other site 402881001188 FMN binding site [chemical binding]; other site 402881001189 putative catalytic residues [active] 402881001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881001191 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 402881001192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881001193 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 402881001194 Prostaglandin dehydrogenases; Region: PGDH; cd05288 402881001195 NAD(P) binding site [chemical binding]; other site 402881001196 substrate binding site [chemical binding]; other site 402881001197 dimer interface [polypeptide binding]; other site 402881001198 Family of unknown function (DUF490); Region: DUF490; pfam04357 402881001199 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 402881001200 Surface antigen; Region: Bac_surface_Ag; pfam01103 402881001201 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 402881001202 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881001203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881001204 motif II; other site 402881001205 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 402881001206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881001207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881001208 non-specific DNA binding site [nucleotide binding]; other site 402881001209 salt bridge; other site 402881001210 sequence-specific DNA binding site [nucleotide binding]; other site 402881001211 Domain of unknown function (DUF955); Region: DUF955; cl01076 402881001212 Beta protein; Region: Beta_protein; pfam14350 402881001213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881001214 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881001215 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881001216 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 402881001217 catalytic site [active] 402881001218 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 402881001219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881001220 short chain dehydrogenase; Provisional; Region: PRK07832 402881001221 NAD(P) binding site [chemical binding]; other site 402881001222 active site 402881001223 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881001224 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881001225 active site 402881001226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 402881001227 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 402881001228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881001229 dimer interface [polypeptide binding]; other site 402881001230 phosphorylation site [posttranslational modification] 402881001231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881001232 ATP binding site [chemical binding]; other site 402881001233 Mg2+ binding site [ion binding]; other site 402881001234 G-X-G motif; other site 402881001235 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 402881001236 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 402881001237 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 402881001238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881001239 dimer interface [polypeptide binding]; other site 402881001240 conserved gate region; other site 402881001241 putative PBP binding loops; other site 402881001242 ABC-ATPase subunit interface; other site 402881001243 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 402881001244 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 402881001245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881001246 dimer interface [polypeptide binding]; other site 402881001247 conserved gate region; other site 402881001248 putative PBP binding loops; other site 402881001249 ABC-ATPase subunit interface; other site 402881001250 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 402881001251 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 402881001252 Walker A/P-loop; other site 402881001253 ATP binding site [chemical binding]; other site 402881001254 Q-loop/lid; other site 402881001255 ABC transporter signature motif; other site 402881001256 Walker B; other site 402881001257 D-loop; other site 402881001258 H-loop/switch region; other site 402881001259 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 402881001260 PhoU domain; Region: PhoU; pfam01895 402881001261 PhoU domain; Region: PhoU; pfam01895 402881001262 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 402881001263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881001264 active site 402881001265 phosphorylation site [posttranslational modification] 402881001266 intermolecular recognition site; other site 402881001267 dimerization interface [polypeptide binding]; other site 402881001268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881001269 DNA binding site [nucleotide binding] 402881001270 GcrA cell cycle regulator; Region: GcrA; cl11564 402881001271 ABC-2 type transporter; Region: ABC2_membrane; cl17235 402881001272 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881001273 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 402881001274 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 402881001275 inhibitor-cofactor binding pocket; inhibition site 402881001276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881001277 catalytic residue [active] 402881001278 ornithine carbamoyltransferase; Provisional; Region: PRK00779 402881001279 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 402881001280 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 402881001281 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 402881001282 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 402881001283 dimerization interface [polypeptide binding]; other site 402881001284 domain crossover interface; other site 402881001285 redox-dependent activation switch; other site 402881001286 Sensors of blue-light using FAD; Region: BLUF; pfam04940 402881001287 acetylornithine deacetylase; Provisional; Region: PRK07522 402881001288 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 402881001289 metal binding site [ion binding]; metal-binding site 402881001290 putative dimer interface [polypeptide binding]; other site 402881001291 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 402881001292 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 402881001293 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 402881001294 homodimer interface [polypeptide binding]; other site 402881001295 substrate-cofactor binding pocket; other site 402881001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881001297 catalytic residue [active] 402881001298 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 402881001299 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 402881001300 trimer interface [polypeptide binding]; other site 402881001301 active site 402881001302 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 402881001303 trimer interface [polypeptide binding]; other site 402881001304 active site 402881001305 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 402881001306 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 402881001307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881001308 Radical SAM superfamily; Region: Radical_SAM; pfam04055 402881001309 FeS/SAM binding site; other site 402881001310 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 402881001311 short chain dehydrogenase; Provisional; Region: PRK06701 402881001312 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 402881001313 NAD binding site [chemical binding]; other site 402881001314 metal binding site [ion binding]; metal-binding site 402881001315 active site 402881001316 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 402881001317 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 402881001318 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 402881001319 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 402881001320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881001321 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 402881001322 BCCT family transporter; Region: BCCT; cl00569 402881001323 malonyl-CoA synthase; Validated; Region: PRK07514 402881001324 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 402881001325 acyl-activating enzyme (AAE) consensus motif; other site 402881001326 active site 402881001327 AMP binding site [chemical binding]; other site 402881001328 CoA binding site [chemical binding]; other site 402881001329 Response regulator receiver domain; Region: Response_reg; pfam00072 402881001330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881001331 active site 402881001332 phosphorylation site [posttranslational modification] 402881001333 intermolecular recognition site; other site 402881001334 dimerization interface [polypeptide binding]; other site 402881001335 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 402881001336 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 402881001337 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 402881001338 DXD motif; other site 402881001339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 402881001340 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 402881001341 substrate binding pocket [chemical binding]; other site 402881001342 membrane-bound complex binding site; other site 402881001343 hinge residues; other site 402881001344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 402881001345 catalytic core [active] 402881001346 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 402881001347 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 402881001348 tellurite resistance protein terB; Region: terB; cd07176 402881001349 putative metal binding site [ion binding]; other site 402881001350 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 402881001351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881001352 dimer interface [polypeptide binding]; other site 402881001353 phosphorylation site [posttranslational modification] 402881001354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881001355 ATP binding site [chemical binding]; other site 402881001356 Mg2+ binding site [ion binding]; other site 402881001357 G-X-G motif; other site 402881001358 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 402881001359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 402881001360 active site 402881001361 nucleotide binding site [chemical binding]; other site 402881001362 HIGH motif; other site 402881001363 KMSKS motif; other site 402881001364 TPR repeat; Region: TPR_11; pfam13414 402881001365 Predicted transcriptional regulator [Transcription]; Region: COG2932 402881001366 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 402881001367 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 402881001368 Catalytic site [active] 402881001369 Protein of unknown function (DUF952); Region: DUF952; cl01393 402881001370 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 402881001371 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 402881001372 quinone interaction residues [chemical binding]; other site 402881001373 active site 402881001374 catalytic residues [active] 402881001375 FMN binding site [chemical binding]; other site 402881001376 substrate binding site [chemical binding]; other site 402881001377 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 402881001378 ArsC family; Region: ArsC; pfam03960 402881001379 catalytic residues [active] 402881001380 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 402881001381 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 402881001382 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881001383 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 402881001384 CoenzymeA binding site [chemical binding]; other site 402881001385 subunit interaction site [polypeptide binding]; other site 402881001386 PHB binding site; other site 402881001387 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881001388 CoenzymeA binding site [chemical binding]; other site 402881001389 subunit interaction site [polypeptide binding]; other site 402881001390 PHB binding site; other site 402881001391 PAS domain; Region: PAS_5; pfam07310 402881001392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881001393 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881001394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881001395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881001396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881001397 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881001398 hypothetical protein; Provisional; Region: PRK09272 402881001399 Predicted membrane protein [Function unknown]; Region: COG2119 402881001400 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 402881001401 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 402881001402 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881001403 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881001404 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 402881001405 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 402881001406 NAD(P) binding site [chemical binding]; other site 402881001407 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 402881001408 short chain dehydrogenase; Provisional; Region: PRK07677 402881001409 NAD(P) binding site [chemical binding]; other site 402881001410 substrate binding site [chemical binding]; other site 402881001411 homotetramer interface [polypeptide binding]; other site 402881001412 active site 402881001413 homodimer interface [polypeptide binding]; other site 402881001414 Mechanosensitive ion channel; Region: MS_channel; pfam00924 402881001415 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 402881001416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881001417 ATP binding site [chemical binding]; other site 402881001418 putative Mg++ binding site [ion binding]; other site 402881001419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881001420 nucleotide binding region [chemical binding]; other site 402881001421 ATP-binding site [chemical binding]; other site 402881001422 DEAD/H associated; Region: DEAD_assoc; pfam08494 402881001423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 402881001424 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 402881001425 putative active site [active] 402881001426 putative metal binding site [ion binding]; other site 402881001427 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 402881001428 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 402881001429 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 402881001430 Predicted permeases [General function prediction only]; Region: COG0730 402881001431 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881001432 Sel1-like repeats; Region: SEL1; smart00671 402881001433 Sel1-like repeats; Region: SEL1; smart00671 402881001434 Sel1-like repeats; Region: SEL1; smart00671 402881001435 Sel1-like repeats; Region: SEL1; smart00671 402881001436 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 402881001437 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 402881001438 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 402881001439 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 402881001440 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 402881001441 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 402881001442 DNA binding residues [nucleotide binding] 402881001443 putative dimer interface [polypeptide binding]; other site 402881001444 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 402881001445 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 402881001446 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 402881001447 FAD binding site [chemical binding]; other site 402881001448 substrate binding site [chemical binding]; other site 402881001449 catalytic residues [active] 402881001450 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 402881001451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881001452 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881001453 active site 402881001454 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 402881001455 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881001456 dimer interface [polypeptide binding]; other site 402881001457 active site 402881001458 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 402881001459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881001460 substrate binding site [chemical binding]; other site 402881001461 oxyanion hole (OAH) forming residues; other site 402881001462 trimer interface [polypeptide binding]; other site 402881001463 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 402881001464 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 402881001465 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 402881001466 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 402881001467 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 402881001468 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 402881001469 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 402881001470 conserved cys residue [active] 402881001471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 402881001472 conserved cys residue [active] 402881001473 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 402881001474 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 402881001475 conserved cys residue [active] 402881001476 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 402881001477 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881001478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881001479 enoyl-CoA hydratase; Provisional; Region: PRK12478 402881001480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881001481 substrate binding site [chemical binding]; other site 402881001482 oxyanion hole (OAH) forming residues; other site 402881001483 trimer interface [polypeptide binding]; other site 402881001484 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881001485 active site 402881001486 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881001487 active site 402881001488 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881001489 active site 402881001490 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 402881001491 active site 2 [active] 402881001492 active site 1 [active] 402881001493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881001494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881001495 active site 402881001496 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881001497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881001498 enoyl-CoA hydratase; Provisional; Region: PRK08260 402881001499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881001500 substrate binding site [chemical binding]; other site 402881001501 oxyanion hole (OAH) forming residues; other site 402881001502 trimer interface [polypeptide binding]; other site 402881001503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881001504 classical (c) SDRs; Region: SDR_c; cd05233 402881001505 NAD(P) binding site [chemical binding]; other site 402881001506 active site 402881001507 Uncharacterized conserved protein [Function unknown]; Region: COG3461 402881001508 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 402881001509 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881001510 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 402881001511 TPR repeat; Region: TPR_11; pfam13414 402881001512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881001513 TPR motif; other site 402881001514 binding surface 402881001515 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 402881001516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881001517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881001518 S-adenosylmethionine binding site [chemical binding]; other site 402881001519 enoyl-CoA hydratase; Region: PLN02864 402881001520 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 402881001521 active site 1 [active] 402881001522 active site 2 [active] 402881001523 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 402881001524 dimer interaction site [polypeptide binding]; other site 402881001525 substrate-binding tunnel; other site 402881001526 active site 402881001527 catalytic site [active] 402881001528 substrate binding site [chemical binding]; other site 402881001529 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881001530 CoenzymeA binding site [chemical binding]; other site 402881001531 subunit interaction site [polypeptide binding]; other site 402881001532 PHB binding site; other site 402881001533 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881001534 CoenzymeA binding site [chemical binding]; other site 402881001535 subunit interaction site [polypeptide binding]; other site 402881001536 PHB binding site; other site 402881001537 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 402881001538 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881001539 dimer interface [polypeptide binding]; other site 402881001540 active site 402881001541 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 402881001542 active site 2 [active] 402881001543 active site 1 [active] 402881001544 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881001545 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 402881001546 FAD binding site [chemical binding]; other site 402881001547 substrate binding site [chemical binding]; other site 402881001548 catalytic base [active] 402881001549 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 402881001550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881001551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881001552 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881001553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881001554 active site 402881001555 potassium/proton antiporter; Reviewed; Region: PRK05326 402881001556 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 402881001557 TrkA-C domain; Region: TrkA_C; pfam02080 402881001558 Transporter associated domain; Region: CorC_HlyC; smart01091 402881001559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881001560 classical (c) SDRs; Region: SDR_c; cd05233 402881001561 NAD(P) binding site [chemical binding]; other site 402881001562 active site 402881001563 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 402881001564 catalytic triad [active] 402881001565 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 402881001566 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 402881001567 TAP-like protein; Region: Abhydrolase_4; pfam08386 402881001568 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 402881001569 Class I ribonucleotide reductase; Region: RNR_I; cd01679 402881001570 active site 402881001571 dimer interface [polypeptide binding]; other site 402881001572 catalytic residues [active] 402881001573 effector binding site; other site 402881001574 R2 peptide binding site; other site 402881001575 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 402881001576 dimer interface [polypeptide binding]; other site 402881001577 putative radical transfer pathway; other site 402881001578 diiron center [ion binding]; other site 402881001579 tyrosyl radical; other site 402881001580 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 402881001581 IHF - DNA interface [nucleotide binding]; other site 402881001582 IHF dimer interface [polypeptide binding]; other site 402881001583 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 402881001584 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881001585 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 402881001586 putative C-terminal domain interface [polypeptide binding]; other site 402881001587 putative GSH binding site (G-site) [chemical binding]; other site 402881001588 putative dimer interface [polypeptide binding]; other site 402881001589 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881001590 N-terminal domain interface [polypeptide binding]; other site 402881001591 dimer interface [polypeptide binding]; other site 402881001592 substrate binding pocket (H-site) [chemical binding]; other site 402881001593 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 402881001594 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 402881001595 intersubunit interface [polypeptide binding]; other site 402881001596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 402881001597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 402881001598 ABC-ATPase subunit interface; other site 402881001599 dimer interface [polypeptide binding]; other site 402881001600 putative PBP binding regions; other site 402881001601 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 402881001602 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 402881001603 Walker A/P-loop; other site 402881001604 ATP binding site [chemical binding]; other site 402881001605 Q-loop/lid; other site 402881001606 ABC transporter signature motif; other site 402881001607 Walker B; other site 402881001608 D-loop; other site 402881001609 H-loop/switch region; other site 402881001610 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 402881001611 dinuclear metal binding motif [ion binding]; other site 402881001612 DNA photolyase; Region: DNA_photolyase; pfam00875 402881001613 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 402881001614 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 402881001615 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 402881001616 YhhN-like protein; Region: YhhN; pfam07947 402881001617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881001618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 402881001619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881001620 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 402881001621 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 402881001622 hinge; other site 402881001623 active site 402881001624 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 402881001625 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 402881001626 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 402881001627 NAD binding site [chemical binding]; other site 402881001628 dimerization interface [polypeptide binding]; other site 402881001629 product binding site; other site 402881001630 substrate binding site [chemical binding]; other site 402881001631 zinc binding site [ion binding]; other site 402881001632 catalytic residues [active] 402881001633 hypothetical protein; Provisional; Region: PRK02853 402881001634 Low molecular weight phosphatase family; Region: LMWPc; cl00105 402881001635 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 402881001636 active site 402881001637 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 402881001638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881001639 Coenzyme A binding pocket [chemical binding]; other site 402881001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 402881001641 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 402881001642 rRNA binding site [nucleotide binding]; other site 402881001643 predicted 30S ribosome binding site; other site 402881001644 Maf-like protein; Provisional; Region: PRK14361 402881001645 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 402881001646 active site 402881001647 dimer interface [polypeptide binding]; other site 402881001648 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 402881001649 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 402881001650 homodimer interface [polypeptide binding]; other site 402881001651 oligonucleotide binding site [chemical binding]; other site 402881001652 Domain of unknown function (DUF329); Region: DUF329; cl01144 402881001653 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 402881001654 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881001655 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881001656 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 402881001657 Protein export membrane protein; Region: SecD_SecF; cl14618 402881001658 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 402881001659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881001660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881001661 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 402881001662 tartrate dehydrogenase; Region: TTC; TIGR02089 402881001663 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 402881001664 Transcriptional regulators [Transcription]; Region: FadR; COG2186 402881001665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 402881001666 DNA-binding site [nucleotide binding]; DNA binding site 402881001667 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 402881001668 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 402881001669 Citrate transporter; Region: CitMHS; pfam03600 402881001670 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 402881001671 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 402881001672 putative ligand binding site [chemical binding]; other site 402881001673 putative NAD binding site [chemical binding]; other site 402881001674 catalytic site [active] 402881001675 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 402881001676 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 402881001677 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 402881001678 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 402881001679 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 402881001680 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 402881001681 active site 402881001682 homodimer interface [polypeptide binding]; other site 402881001683 catalytic site [active] 402881001684 acceptor binding site [chemical binding]; other site 402881001685 trehalose synthase; Region: treS_nterm; TIGR02456 402881001686 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 402881001687 active site 402881001688 catalytic site [active] 402881001689 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 402881001690 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 402881001691 glycogen branching enzyme; Provisional; Region: PRK05402 402881001692 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 402881001693 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 402881001694 active site 402881001695 catalytic site [active] 402881001696 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 402881001697 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 402881001698 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 402881001699 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 402881001700 active site 402881001701 catalytic site [active] 402881001702 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 402881001703 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 402881001704 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 402881001705 catalytic site [active] 402881001706 active site 402881001707 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 402881001708 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 402881001709 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 402881001710 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 402881001711 active site 402881001712 catalytic site [active] 402881001713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881001714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881001715 classical (c) SDRs; Region: SDR_c; cd05233 402881001716 NAD(P) binding site [chemical binding]; other site 402881001717 active site 402881001718 Cupin domain; Region: Cupin_2; cl17218 402881001719 AsmA family; Region: AsmA; pfam05170 402881001720 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 402881001721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 402881001722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881001723 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 402881001724 Walker A/P-loop; other site 402881001725 ATP binding site [chemical binding]; other site 402881001726 Q-loop/lid; other site 402881001727 ABC transporter signature motif; other site 402881001728 Walker B; other site 402881001729 D-loop; other site 402881001730 H-loop/switch region; other site 402881001731 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 402881001732 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 402881001733 acyl-activating enzyme (AAE) consensus motif; other site 402881001734 putative AMP binding site [chemical binding]; other site 402881001735 putative active site [active] 402881001736 putative CoA binding site [chemical binding]; other site 402881001737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881001738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881001739 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 402881001740 Na2 binding site [ion binding]; other site 402881001741 putative substrate binding site 1 [chemical binding]; other site 402881001742 Na binding site 1 [ion binding]; other site 402881001743 putative substrate binding site 2 [chemical binding]; other site 402881001744 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881001745 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881001746 C-terminal domain interface [polypeptide binding]; other site 402881001747 GSH binding site (G-site) [chemical binding]; other site 402881001748 dimer interface [polypeptide binding]; other site 402881001749 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 402881001750 dimer interface [polypeptide binding]; other site 402881001751 N-terminal domain interface [polypeptide binding]; other site 402881001752 substrate binding pocket (H-site) [chemical binding]; other site 402881001753 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 402881001754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881001755 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 402881001756 acyl-activating enzyme (AAE) consensus motif; other site 402881001757 putative AMP binding site [chemical binding]; other site 402881001758 putative active site [active] 402881001759 putative CoA binding site [chemical binding]; other site 402881001760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 402881001761 classical (c) SDRs; Region: SDR_c; cd05233 402881001762 NAD(P) binding site [chemical binding]; other site 402881001763 active site 402881001764 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 402881001765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 402881001766 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 402881001767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 402881001768 active site 402881001769 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 402881001770 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 402881001771 active site 402881001772 putative substrate binding pocket [chemical binding]; other site 402881001773 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881001774 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 402881001775 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 402881001776 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 402881001777 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 402881001778 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 402881001779 D-pathway; other site 402881001780 Putative ubiquinol binding site [chemical binding]; other site 402881001781 Low-spin heme (heme b) binding site [chemical binding]; other site 402881001782 Putative water exit pathway; other site 402881001783 Binuclear center (heme o3/CuB) [ion binding]; other site 402881001784 K-pathway; other site 402881001785 Putative proton exit pathway; other site 402881001786 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 402881001787 Subunit I/III interface [polypeptide binding]; other site 402881001788 enoyl-CoA hydratase; Provisional; Region: PRK06190 402881001789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881001790 substrate binding site [chemical binding]; other site 402881001791 oxyanion hole (OAH) forming residues; other site 402881001792 trimer interface [polypeptide binding]; other site 402881001793 Protein of unknown function (DUF819); Region: DUF819; cl02317 402881001794 Protein of unknown function (DUF819); Region: DUF819; cl02317 402881001795 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 402881001796 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 402881001797 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881001798 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881001799 acyl-activating enzyme (AAE) consensus motif; other site 402881001800 acyl-activating enzyme (AAE) consensus motif; other site 402881001801 putative AMP binding site [chemical binding]; other site 402881001802 putative active site [active] 402881001803 putative CoA binding site [chemical binding]; other site 402881001804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881001805 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 402881001806 putative substrate translocation pore; other site 402881001807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881001808 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 402881001809 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 402881001810 MFS/sugar transport protein; Region: MFS_2; pfam13347 402881001811 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 402881001812 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 402881001813 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 402881001814 active site 402881001815 putative substrate binding pocket [chemical binding]; other site 402881001816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881001817 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 402881001818 substrate binding pocket [chemical binding]; other site 402881001819 active site 402881001820 PGAP1-like protein; Region: PGAP1; pfam07819 402881001821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881001822 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 402881001823 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881001824 FMN binding site [chemical binding]; other site 402881001825 substrate binding site [chemical binding]; other site 402881001826 putative catalytic residue [active] 402881001827 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 402881001828 spermidine synthase; Provisional; Region: PRK00811 402881001829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881001830 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 402881001831 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881001832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881001833 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881001834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881001835 non-specific DNA binding site [nucleotide binding]; other site 402881001836 salt bridge; other site 402881001837 sequence-specific DNA binding site [nucleotide binding]; other site 402881001838 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 402881001839 Right handed beta helix region; Region: Beta_helix; pfam13229 402881001840 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 402881001841 Right handed beta helix region; Region: Beta_helix; pfam13229 402881001842 isocitrate lyase; Provisional; Region: PRK15063 402881001843 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 402881001844 tetramer interface [polypeptide binding]; other site 402881001845 active site 402881001846 Mg2+/Mn2+ binding site [ion binding]; other site 402881001847 malate synthase A; Region: malate_syn_A; TIGR01344 402881001848 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 402881001849 active site 402881001850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881001851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881001852 sequence-specific DNA binding site [nucleotide binding]; other site 402881001853 salt bridge; other site 402881001854 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 402881001855 Domain of unknown function (DUF955); Region: DUF955; pfam06114 402881001856 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 402881001857 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 402881001858 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 402881001859 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 402881001860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881001861 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 402881001862 putative active site [active] 402881001863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881001864 dimer interface [polypeptide binding]; other site 402881001865 phosphorylation site [posttranslational modification] 402881001866 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 402881001867 ATP binding site [chemical binding]; other site 402881001868 G-X-G motif; other site 402881001869 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 402881001870 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 402881001871 dimer interface [polypeptide binding]; other site 402881001872 motif 1; other site 402881001873 motif 2; other site 402881001874 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 402881001875 active site 402881001876 motif 3; other site 402881001877 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 402881001878 anticodon binding site; other site 402881001879 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 402881001880 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 402881001881 motif 1; other site 402881001882 dimer interface [polypeptide binding]; other site 402881001883 active site 402881001884 motif 2; other site 402881001885 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 402881001886 active site 402881001887 motif 3; other site 402881001888 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 402881001889 ATP phosphoribosyltransferase; Region: HisG; cl15266 402881001890 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 402881001891 classical (c) SDRs; Region: SDR_c; cd05233 402881001892 NAD(P) binding site [chemical binding]; other site 402881001893 active site 402881001894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881001895 hypothetical protein; Provisional; Region: PRK07236 402881001896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881001897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881001898 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 402881001899 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 402881001900 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 402881001901 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 402881001902 THF binding site; other site 402881001903 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 402881001904 substrate binding site [chemical binding]; other site 402881001905 THF binding site; other site 402881001906 zinc-binding site [ion binding]; other site 402881001907 Protein of unknown function DUF72; Region: DUF72; pfam01904 402881001908 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 402881001909 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 402881001910 dimer interface [polypeptide binding]; other site 402881001911 active site 402881001912 glycine-pyridoxal phosphate binding site [chemical binding]; other site 402881001913 folate binding site [chemical binding]; other site 402881001914 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881001915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881001916 active site 402881001917 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 402881001918 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 402881001919 ring oligomerisation interface [polypeptide binding]; other site 402881001920 ATP/Mg binding site [chemical binding]; other site 402881001921 stacking interactions; other site 402881001922 hinge regions; other site 402881001923 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 402881001924 oligomerisation interface [polypeptide binding]; other site 402881001925 mobile loop; other site 402881001926 roof hairpin; other site 402881001927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881001928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881001929 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 402881001930 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 402881001931 dimer interface [polypeptide binding]; other site 402881001932 active site 402881001933 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 402881001934 substrate binding site [chemical binding]; other site 402881001935 catalytic residue [active] 402881001936 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 402881001937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 402881001938 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 402881001939 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 402881001940 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 402881001941 active site 402881001942 ADP/pyrophosphate binding site [chemical binding]; other site 402881001943 dimerization interface [polypeptide binding]; other site 402881001944 allosteric effector site; other site 402881001945 fructose-1,6-bisphosphate binding site; other site 402881001946 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 402881001947 Coenzyme A binding pocket [chemical binding]; other site 402881001948 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 402881001949 putative active site [active] 402881001950 putative substrate binding site [chemical binding]; other site 402881001951 ATP binding site [chemical binding]; other site 402881001952 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 402881001953 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 402881001954 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 402881001955 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 402881001956 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 402881001957 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 402881001958 generic binding surface II; other site 402881001959 generic binding surface I; other site 402881001960 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 402881001961 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 402881001962 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881001963 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 402881001964 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 402881001965 putative acyl-acceptor binding pocket; other site 402881001966 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 402881001967 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 402881001968 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 402881001969 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 402881001970 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 402881001971 putative acyl-acceptor binding pocket; other site 402881001972 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 402881001973 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881001974 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 402881001975 Walker A/P-loop; other site 402881001976 ATP binding site [chemical binding]; other site 402881001977 Q-loop/lid; other site 402881001978 ABC transporter signature motif; other site 402881001979 Walker B; other site 402881001980 D-loop; other site 402881001981 H-loop/switch region; other site 402881001982 TspO/MBR family; Region: TspO_MBR; pfam03073 402881001983 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 402881001984 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 402881001985 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 402881001986 active site 402881001987 peptidase PmbA; Provisional; Region: PRK11040 402881001988 MAPEG family; Region: MAPEG; cl09190 402881001989 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 402881001990 putative ADP-ribose binding site [chemical binding]; other site 402881001991 putative active site [active] 402881001992 hypothetical protein; Provisional; Region: PRK09256 402881001993 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 402881001994 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 402881001995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881001996 non-specific DNA binding site [nucleotide binding]; other site 402881001997 salt bridge; other site 402881001998 sequence-specific DNA binding site [nucleotide binding]; other site 402881001999 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 402881002000 enoyl-CoA hydratase; Provisional; Region: PRK06688 402881002001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881002002 substrate binding site [chemical binding]; other site 402881002003 oxyanion hole (OAH) forming residues; other site 402881002004 trimer interface [polypeptide binding]; other site 402881002005 Predicted methyltransferase [General function prediction only]; Region: COG3897 402881002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881002007 S-adenosylmethionine binding site [chemical binding]; other site 402881002008 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 402881002009 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 402881002010 active site 402881002011 Riboflavin kinase; Region: Flavokinase; smart00904 402881002012 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 402881002013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881002014 active site 402881002015 motif I; other site 402881002016 motif II; other site 402881002017 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 402881002018 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 402881002019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881002020 S-adenosylmethionine binding site [chemical binding]; other site 402881002021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 402881002022 RNA binding surface [nucleotide binding]; other site 402881002023 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 402881002024 pseudouridine synthase; Region: TIGR00093 402881002025 active site 402881002026 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 402881002027 nucleoside/Zn binding site; other site 402881002028 dimer interface [polypeptide binding]; other site 402881002029 catalytic motif [active] 402881002030 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002031 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 402881002032 FAD binding site [chemical binding]; other site 402881002033 substrate binding site [chemical binding]; other site 402881002034 catalytic base [active] 402881002035 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881002036 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881002037 C-terminal domain interface [polypeptide binding]; other site 402881002038 GSH binding site (G-site) [chemical binding]; other site 402881002039 dimer interface [polypeptide binding]; other site 402881002040 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 402881002041 N-terminal domain interface [polypeptide binding]; other site 402881002042 dimer interface [polypeptide binding]; other site 402881002043 substrate binding pocket (H-site) [chemical binding]; other site 402881002044 PAS domain S-box; Region: sensory_box; TIGR00229 402881002045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881002046 putative active site [active] 402881002047 heme pocket [chemical binding]; other site 402881002048 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 402881002049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881002050 putative active site [active] 402881002051 heme pocket [chemical binding]; other site 402881002052 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 402881002053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881002054 putative active site [active] 402881002055 heme pocket [chemical binding]; other site 402881002056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881002057 dimer interface [polypeptide binding]; other site 402881002058 phosphorylation site [posttranslational modification] 402881002059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881002060 ATP binding site [chemical binding]; other site 402881002061 Mg2+ binding site [ion binding]; other site 402881002062 G-X-G motif; other site 402881002063 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 402881002064 putative active site [active] 402881002065 putative substrate binding site [chemical binding]; other site 402881002066 ATP binding site [chemical binding]; other site 402881002067 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 402881002068 Fatty acid desaturase; Region: FA_desaturase; pfam00487 402881002069 putative di-iron ligands [ion binding]; other site 402881002070 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 402881002071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881002072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881002073 H+ Antiporter protein; Region: 2A0121; TIGR00900 402881002074 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 402881002075 UbiA prenyltransferase family; Region: UbiA; pfam01040 402881002076 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 402881002077 nudix motif; other site 402881002078 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 402881002079 RNA methyltransferase, RsmE family; Region: TIGR00046 402881002080 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 402881002081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 402881002082 glutamate--cysteine ligase; Region: PLN02611 402881002083 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 402881002084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881002085 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 402881002086 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 402881002087 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 402881002088 putative active site [active] 402881002089 topology modulation protein; Reviewed; Region: PRK08118 402881002090 AAA domain; Region: AAA_17; pfam13207 402881002091 DinB family; Region: DinB; cl17821 402881002092 Cupin domain; Region: Cupin_2; pfam07883 402881002093 Cupin domain; Region: Cupin_2; cl17218 402881002094 Helix-turn-helix domain; Region: HTH_18; pfam12833 402881002095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881002096 protease TldD; Provisional; Region: tldD; PRK10735 402881002097 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 402881002098 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00117 402881002099 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 402881002100 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 402881002101 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 402881002102 Subunit I/III interface [polypeptide binding]; other site 402881002103 D-pathway; other site 402881002104 Subunit I/VIIc interface [polypeptide binding]; other site 402881002105 Subunit I/IV interface [polypeptide binding]; other site 402881002106 Subunit I/II interface [polypeptide binding]; other site 402881002107 Low-spin heme (heme a) binding site [chemical binding]; other site 402881002108 Subunit I/VIIa interface [polypeptide binding]; other site 402881002109 Subunit I/VIa interface [polypeptide binding]; other site 402881002110 Dimer interface; other site 402881002111 Putative water exit pathway; other site 402881002112 Binuclear center (heme a3/CuB) [ion binding]; other site 402881002113 K-pathway; other site 402881002114 Subunit I/Vb interface [polypeptide binding]; other site 402881002115 Putative proton exit pathway; other site 402881002116 Subunit I/VIb interface; other site 402881002117 Subunit I/VIc interface [polypeptide binding]; other site 402881002118 Electron transfer pathway; other site 402881002119 Subunit I/VIIIb interface [polypeptide binding]; other site 402881002120 Subunit I/VIIb interface [polypeptide binding]; other site 402881002121 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 402881002122 UbiA prenyltransferase family; Region: UbiA; pfam01040 402881002123 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 402881002124 Subunit III/VIIa interface [polypeptide binding]; other site 402881002125 Phospholipid binding site [chemical binding]; other site 402881002126 Subunit I/III interface [polypeptide binding]; other site 402881002127 Subunit III/VIb interface [polypeptide binding]; other site 402881002128 Subunit III/VIa interface; other site 402881002129 Subunit III/Vb interface [polypeptide binding]; other site 402881002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 402881002131 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 402881002132 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 402881002133 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 402881002134 active site 402881002135 Zn binding site [ion binding]; other site 402881002136 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 402881002137 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 402881002138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881002139 catalytic residue [active] 402881002140 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 402881002141 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 402881002142 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 402881002143 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 402881002144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 402881002145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881002146 PAS fold; Region: PAS_3; pfam08447 402881002147 putative active site [active] 402881002148 heme pocket [chemical binding]; other site 402881002149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 402881002150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881002151 metal binding site [ion binding]; metal-binding site 402881002152 active site 402881002153 I-site; other site 402881002154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 402881002155 hypothetical protein; Validated; Region: PRK00228 402881002156 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 402881002157 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 402881002158 catalytic triad [active] 402881002159 dimer interface [polypeptide binding]; other site 402881002160 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 402881002161 RNA/DNA hybrid binding site [nucleotide binding]; other site 402881002162 active site 402881002163 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 402881002164 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 402881002165 putative active site [active] 402881002166 putative substrate binding site [chemical binding]; other site 402881002167 ATP binding site [chemical binding]; other site 402881002168 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 402881002169 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 402881002170 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 402881002171 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 402881002172 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 402881002173 lipoyl attachment site [posttranslational modification]; other site 402881002174 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 402881002175 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 402881002176 tetramer interface [polypeptide binding]; other site 402881002177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881002178 catalytic residue [active] 402881002179 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 402881002180 tetramer interface [polypeptide binding]; other site 402881002181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881002182 catalytic residue [active] 402881002183 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 402881002184 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 402881002185 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 402881002186 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 402881002187 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 402881002188 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 402881002189 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 402881002190 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 402881002191 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 402881002192 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 402881002193 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 402881002194 Walker A/P-loop; other site 402881002195 ATP binding site [chemical binding]; other site 402881002196 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 402881002197 ABC transporter signature motif; other site 402881002198 Walker B; other site 402881002199 D-loop; other site 402881002200 H-loop/switch region; other site 402881002201 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 402881002202 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 402881002203 Thioredoxin; Region: Thioredoxin_4; pfam13462 402881002204 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 402881002205 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 402881002206 minor groove reading motif; other site 402881002207 helix-hairpin-helix signature motif; other site 402881002208 substrate binding pocket [chemical binding]; other site 402881002209 active site 402881002210 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 402881002211 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 402881002212 DNA binding and oxoG recognition site [nucleotide binding] 402881002213 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 402881002214 DNA methylase; Region: N6_N4_Mtase; pfam01555 402881002215 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 402881002216 RNA/DNA hybrid binding site [nucleotide binding]; other site 402881002217 active site 402881002218 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881002219 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881002220 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881002221 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881002222 MarR family; Region: MarR; pfam01047 402881002223 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 402881002224 GIY-YIG motif/motif A; other site 402881002225 putative active site [active] 402881002226 putative metal binding site [ion binding]; other site 402881002227 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 402881002228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881002229 FeS/SAM binding site; other site 402881002230 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 402881002231 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 402881002232 Probable Catalytic site; other site 402881002233 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 402881002234 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 402881002235 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 402881002236 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 402881002237 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 402881002238 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 402881002239 MPT binding site; other site 402881002240 trimer interface [polypeptide binding]; other site 402881002241 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 402881002242 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881002243 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881002244 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881002245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881002246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881002247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881002248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881002249 catalytic residue [active] 402881002250 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 402881002251 Fe-S cluster binding site [ion binding]; other site 402881002252 active site 402881002253 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 402881002254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 402881002255 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 402881002256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 402881002257 binding surface 402881002258 TPR motif; other site 402881002259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881002260 binding surface 402881002261 TPR motif; other site 402881002262 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 402881002263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881002264 TPR motif; other site 402881002265 binding surface 402881002266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881002267 binding surface 402881002268 TPR motif; other site 402881002269 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 402881002270 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 402881002271 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 402881002272 substrate binding pocket [chemical binding]; other site 402881002273 chain length determination region; other site 402881002274 substrate-Mg2+ binding site; other site 402881002275 catalytic residues [active] 402881002276 aspartate-rich region 1; other site 402881002277 active site lid residues [active] 402881002278 aspartate-rich region 2; other site 402881002279 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 402881002280 Methyltransferase domain; Region: Methyltransf_26; pfam13659 402881002281 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 402881002282 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 402881002283 tandem repeat interface [polypeptide binding]; other site 402881002284 oligomer interface [polypeptide binding]; other site 402881002285 active site residues [active] 402881002286 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 402881002287 dimer interface [polypeptide binding]; other site 402881002288 motif 1; other site 402881002289 active site 402881002290 motif 2; other site 402881002291 motif 3; other site 402881002292 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 402881002293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 402881002294 pyruvate phosphate dikinase; Provisional; Region: PRK09279 402881002295 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 402881002296 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 402881002297 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 402881002298 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 402881002299 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 402881002300 short chain dehydrogenase; Provisional; Region: PRK08267 402881002301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881002302 NAD(P) binding site [chemical binding]; other site 402881002303 active site 402881002304 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 402881002305 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 402881002306 dimerization interface [polypeptide binding]; other site 402881002307 active site 402881002308 L-aspartate oxidase; Provisional; Region: PRK07512 402881002309 L-aspartate oxidase; Provisional; Region: PRK06175 402881002310 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 402881002311 quinolinate synthetase; Provisional; Region: PRK09375 402881002312 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 402881002313 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 402881002314 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 402881002315 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 402881002316 AAA domain; Region: AAA_32; pfam13654 402881002317 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 402881002318 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 402881002319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881002320 Ligand Binding Site [chemical binding]; other site 402881002321 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 402881002322 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 402881002323 dimer interface [polypeptide binding]; other site 402881002324 active site 402881002325 CoA binding pocket [chemical binding]; other site 402881002326 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 402881002327 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 402881002328 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 402881002329 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 402881002330 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 402881002331 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 402881002332 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 402881002333 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 402881002334 putative active site [active] 402881002335 dihydroorotase; Validated; Region: PRK09060 402881002336 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881002337 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 402881002338 active site 402881002339 Usg-like family; Region: Usg; pfam06233 402881002340 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 402881002341 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 402881002342 NADP binding site [chemical binding]; other site 402881002343 dimer interface [polypeptide binding]; other site 402881002344 acyl-CoA synthetase; Provisional; Region: PRK12582 402881002345 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 402881002346 acyl-activating enzyme (AAE) consensus motif; other site 402881002347 putative AMP binding site [chemical binding]; other site 402881002348 putative active site [active] 402881002349 putative CoA binding site [chemical binding]; other site 402881002350 hypothetical protein; Validated; Region: PRK07586 402881002351 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 402881002352 PYR/PP interface [polypeptide binding]; other site 402881002353 dimer interface [polypeptide binding]; other site 402881002354 TPP binding site [chemical binding]; other site 402881002355 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 402881002356 TPP-binding site [chemical binding]; other site 402881002357 dimer interface [polypeptide binding]; other site 402881002358 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 402881002359 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 402881002360 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881002361 FMN binding site [chemical binding]; other site 402881002362 substrate binding site [chemical binding]; other site 402881002363 putative catalytic residue [active] 402881002364 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 402881002365 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 402881002366 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 402881002367 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 402881002368 phosphate binding site [ion binding]; other site 402881002369 MarR family; Region: MarR_2; cl17246 402881002370 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881002371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881002372 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881002373 NAD(P) binding site [chemical binding]; other site 402881002374 active site 402881002375 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 402881002376 metal binding site 2 [ion binding]; metal-binding site 402881002377 putative DNA binding helix; other site 402881002378 metal binding site 1 [ion binding]; metal-binding site 402881002379 dimer interface [polypeptide binding]; other site 402881002380 structural Zn2+ binding site [ion binding]; other site 402881002381 Uncharacterized conserved protein [Function unknown]; Region: COG2135 402881002382 putative acetyltransferase; Provisional; Region: PRK03624 402881002383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881002384 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 402881002385 Domain of unknown function DUF21; Region: DUF21; pfam01595 402881002386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 402881002387 Transporter associated domain; Region: CorC_HlyC; smart01091 402881002388 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 402881002389 FAD binding domain; Region: FAD_binding_4; pfam01565 402881002390 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 402881002391 GIY-YIG motif/motif A; other site 402881002392 putative active site [active] 402881002393 putative metal binding site [ion binding]; other site 402881002394 Beta-lactamase; Region: Beta-lactamase; pfam00144 402881002395 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 402881002396 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 402881002397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 402881002398 active site 402881002399 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 402881002400 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 402881002401 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 402881002402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881002404 active site 402881002405 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 402881002406 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 402881002407 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 402881002408 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 402881002409 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 402881002410 putative active site [active] 402881002411 Zn binding site [ion binding]; other site 402881002412 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 402881002413 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 402881002414 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 402881002415 substrate binding pocket [chemical binding]; other site 402881002416 chain length determination region; other site 402881002417 substrate-Mg2+ binding site; other site 402881002418 catalytic residues [active] 402881002419 aspartate-rich region 1; other site 402881002420 active site lid residues [active] 402881002421 aspartate-rich region 2; other site 402881002422 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 402881002423 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 402881002424 TPP-binding site; other site 402881002425 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 402881002426 PYR/PP interface [polypeptide binding]; other site 402881002427 dimer interface [polypeptide binding]; other site 402881002428 TPP binding site [chemical binding]; other site 402881002429 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 402881002430 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 402881002431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 402881002432 RNA binding surface [nucleotide binding]; other site 402881002433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881002434 S-adenosylmethionine binding site [chemical binding]; other site 402881002435 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 402881002436 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 402881002437 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 402881002438 Tetramer interface [polypeptide binding]; other site 402881002439 active site 402881002440 FMN-binding site [chemical binding]; other site 402881002441 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 402881002442 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 402881002443 NAD binding site [chemical binding]; other site 402881002444 homotetramer interface [polypeptide binding]; other site 402881002445 homodimer interface [polypeptide binding]; other site 402881002446 substrate binding site [chemical binding]; other site 402881002447 active site 402881002448 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 402881002449 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 402881002450 HSP70 interaction site [polypeptide binding]; other site 402881002451 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 402881002452 substrate binding site [polypeptide binding]; other site 402881002453 dimer interface [polypeptide binding]; other site 402881002454 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881002455 Sel1-like repeats; Region: SEL1; smart00671 402881002456 Sel1-like repeats; Region: SEL1; smart00671 402881002457 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 402881002458 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 402881002459 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 402881002460 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 402881002461 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 402881002462 Cation efflux family; Region: Cation_efflux; cl00316 402881002463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 402881002464 Predicted kinase [General function prediction only]; Region: COG0645 402881002465 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 402881002466 classical (c) SDRs; Region: SDR_c; cd05233 402881002467 NAD(P) binding site [chemical binding]; other site 402881002468 active site 402881002469 aminotransferase; Provisional; Region: PRK06105 402881002470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 402881002471 inhibitor-cofactor binding pocket; inhibition site 402881002472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881002473 catalytic residue [active] 402881002474 amidase; Provisional; Region: PRK06170 402881002475 Amidase; Region: Amidase; cl11426 402881002476 putative acyl-CoA synthetase; Provisional; Region: PRK06018 402881002477 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 402881002478 dimer interface [polypeptide binding]; other site 402881002479 acyl-activating enzyme (AAE) consensus motif; other site 402881002480 putative active site [active] 402881002481 AMP binding site [chemical binding]; other site 402881002482 putative CoA binding site [chemical binding]; other site 402881002483 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 402881002484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881002485 MarR family; Region: MarR_2; pfam12802 402881002486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881002487 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 402881002488 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881002489 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881002490 acyl-activating enzyme (AAE) consensus motif; other site 402881002491 acyl-activating enzyme (AAE) consensus motif; other site 402881002492 putative AMP binding site [chemical binding]; other site 402881002493 putative active site [active] 402881002494 putative CoA binding site [chemical binding]; other site 402881002495 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 402881002496 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 402881002497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881002498 catalytic residue [active] 402881002499 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 402881002500 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 402881002501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881002502 N-terminal plug; other site 402881002503 ligand-binding site [chemical binding]; other site 402881002504 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 402881002505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881002506 enoyl-CoA hydratase; Provisional; Region: PRK06688 402881002507 substrate binding site [chemical binding]; other site 402881002508 oxyanion hole (OAH) forming residues; other site 402881002509 trimer interface [polypeptide binding]; other site 402881002510 enoyl-CoA hydratase; Provisional; Region: PRK06210 402881002511 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881002512 substrate binding site [chemical binding]; other site 402881002513 oxyanion hole (OAH) forming residues; other site 402881002514 trimer interface [polypeptide binding]; other site 402881002515 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 402881002516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881002517 N-terminal plug; other site 402881002518 ligand-binding site [chemical binding]; other site 402881002519 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881002520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881002521 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 402881002522 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 402881002523 putative oligomer interface [polypeptide binding]; other site 402881002524 putative active site [active] 402881002525 metal binding site [ion binding]; metal-binding site 402881002526 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 402881002527 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 402881002528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881002529 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 402881002530 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 402881002531 active site 402881002532 dimer interface [polypeptide binding]; other site 402881002533 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 402881002534 Ligand Binding Site [chemical binding]; other site 402881002535 Molecular Tunnel; other site 402881002536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 402881002537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881002538 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 402881002539 Walker A/P-loop; other site 402881002540 ATP binding site [chemical binding]; other site 402881002541 Q-loop/lid; other site 402881002542 ABC transporter signature motif; other site 402881002543 Walker B; other site 402881002544 D-loop; other site 402881002545 H-loop/switch region; other site 402881002546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881002547 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 402881002548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881002549 Walker A/P-loop; other site 402881002550 ATP binding site [chemical binding]; other site 402881002551 Q-loop/lid; other site 402881002552 ABC transporter signature motif; other site 402881002553 Walker B; other site 402881002554 D-loop; other site 402881002555 H-loop/switch region; other site 402881002556 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 402881002557 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881002558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881002559 S-adenosylmethionine binding site [chemical binding]; other site 402881002560 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 402881002561 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002562 FAD binding site [chemical binding]; other site 402881002563 substrate binding pocket [chemical binding]; other site 402881002564 catalytic base [active] 402881002565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881002566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881002567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 402881002568 dimerization interface [polypeptide binding]; other site 402881002569 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 402881002570 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 402881002571 putative NAD(P) binding site [chemical binding]; other site 402881002572 putative active site [active] 402881002573 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 402881002574 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881002575 FMN binding site [chemical binding]; other site 402881002576 substrate binding site [chemical binding]; other site 402881002577 putative catalytic residue [active] 402881002578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881002579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881002580 LysR substrate binding domain; Region: LysR_substrate; pfam03466 402881002581 dimerization interface [polypeptide binding]; other site 402881002582 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 402881002583 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881002584 FMN binding site [chemical binding]; other site 402881002585 substrate binding site [chemical binding]; other site 402881002586 putative catalytic residue [active] 402881002587 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 402881002588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 402881002589 ligand binding site [chemical binding]; other site 402881002590 flexible hinge region; other site 402881002591 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 402881002592 putative switch regulator; other site 402881002593 non-specific DNA interactions [nucleotide binding]; other site 402881002594 DNA binding site [nucleotide binding] 402881002595 sequence specific DNA binding site [nucleotide binding]; other site 402881002596 putative cAMP binding site [chemical binding]; other site 402881002597 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881002598 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 402881002599 active site 402881002600 iron coordination sites [ion binding]; other site 402881002601 substrate binding pocket [chemical binding]; other site 402881002602 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 402881002603 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881002604 Beta-lactamase; Region: Beta-lactamase; pfam00144 402881002605 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 402881002606 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 402881002607 Beta-lactamase; Region: Beta-lactamase; pfam00144 402881002608 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 402881002609 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 402881002610 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 402881002611 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 402881002612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881002613 Walker A/P-loop; other site 402881002614 ATP binding site [chemical binding]; other site 402881002615 Q-loop/lid; other site 402881002616 ABC transporter signature motif; other site 402881002617 Walker B; other site 402881002618 D-loop; other site 402881002619 H-loop/switch region; other site 402881002620 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 402881002621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881002622 dimer interface [polypeptide binding]; other site 402881002623 conserved gate region; other site 402881002624 putative PBP binding loops; other site 402881002625 ABC-ATPase subunit interface; other site 402881002626 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 402881002627 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 402881002628 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881002629 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 402881002630 active site 402881002631 iron coordination sites [ion binding]; other site 402881002632 substrate binding pocket [chemical binding]; other site 402881002633 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 402881002634 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 402881002635 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 402881002636 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 402881002637 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 402881002638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881002639 methionine sulfoxide reductase B; Provisional; Region: PRK00222 402881002640 SelR domain; Region: SelR; pfam01641 402881002641 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 402881002642 putative active site [active] 402881002643 putative catalytic site [active] 402881002644 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 402881002645 ligand binding site [chemical binding]; other site 402881002646 acyl-CoA synthetase; Provisional; Region: PRK13391 402881002647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881002648 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881002649 acyl-activating enzyme (AAE) consensus motif; other site 402881002650 putative AMP binding site [chemical binding]; other site 402881002651 putative active site [active] 402881002652 acyl-activating enzyme (AAE) consensus motif; other site 402881002653 putative CoA binding site [chemical binding]; other site 402881002654 enoyl-CoA hydratase; Provisional; Region: PRK08260 402881002655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881002656 substrate binding site [chemical binding]; other site 402881002657 oxyanion hole (OAH) forming residues; other site 402881002658 trimer interface [polypeptide binding]; other site 402881002659 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 402881002660 TrkA-N domain; Region: TrkA_N; pfam02254 402881002661 H+ Antiporter protein; Region: 2A0121; TIGR00900 402881002662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881002663 putative substrate translocation pore; other site 402881002664 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 402881002665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881002666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881002667 H+ Antiporter protein; Region: 2A0121; TIGR00900 402881002668 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 402881002669 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 402881002670 NAD binding site [chemical binding]; other site 402881002671 active site 402881002672 Helix-turn-helix domain; Region: HTH_17; pfam12728 402881002673 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 402881002674 active site 402881002675 coenzyme A binding site [chemical binding]; other site 402881002676 citrylCoA binding site [chemical binding]; other site 402881002677 dimer interface [polypeptide binding]; other site 402881002678 Citrate synthase; Region: Citrate_synt; pfam00285 402881002679 oxalacetate/citrate binding site [chemical binding]; other site 402881002680 catalytic triad [active] 402881002681 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 402881002682 dimer interface [polypeptide binding]; other site 402881002683 Citrate synthase; Region: Citrate_synt; pfam00285 402881002684 active site 402881002685 citrylCoA binding site [chemical binding]; other site 402881002686 oxalacetate/citrate binding site [chemical binding]; other site 402881002687 coenzyme A binding site [chemical binding]; other site 402881002688 catalytic triad [active] 402881002689 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 402881002690 ABC-2 type transporter; Region: ABC2_membrane; cl17235 402881002691 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881002692 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 402881002693 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 402881002694 Walker A/P-loop; other site 402881002695 ATP binding site [chemical binding]; other site 402881002696 Q-loop/lid; other site 402881002697 ABC transporter signature motif; other site 402881002698 Walker B; other site 402881002699 D-loop; other site 402881002700 H-loop/switch region; other site 402881002701 Uncharacterized conserved protein [Function unknown]; Region: COG3268 402881002702 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 402881002703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881002704 non-specific DNA binding site [nucleotide binding]; other site 402881002705 salt bridge; other site 402881002706 sequence-specific DNA binding site [nucleotide binding]; other site 402881002707 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 402881002708 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881002709 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 402881002710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881002711 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881002712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881002713 non-specific DNA binding site [nucleotide binding]; other site 402881002714 salt bridge; other site 402881002715 sequence-specific DNA binding site [nucleotide binding]; other site 402881002716 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 402881002717 DnaA box-binding interface [nucleotide binding]; other site 402881002718 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 402881002719 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 402881002720 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 402881002721 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 402881002722 G1 box; other site 402881002723 putative GEF interaction site [polypeptide binding]; other site 402881002724 GTP/Mg2+ binding site [chemical binding]; other site 402881002725 Switch I region; other site 402881002726 G2 box; other site 402881002727 G3 box; other site 402881002728 Switch II region; other site 402881002729 G4 box; other site 402881002730 G5 box; other site 402881002731 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 402881002732 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 402881002733 Mechanosensitive ion channel; Region: MS_channel; pfam00924 402881002734 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 402881002735 FMN binding site [chemical binding]; other site 402881002736 dimer interface [polypeptide binding]; other site 402881002737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881002738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881002739 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 402881002740 Phasin protein; Region: Phasin_2; pfam09361 402881002741 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 402881002742 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 402881002743 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 402881002744 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 402881002745 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 402881002746 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 402881002747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881002748 dimer interface [polypeptide binding]; other site 402881002749 conserved gate region; other site 402881002750 putative PBP binding loops; other site 402881002751 ABC-ATPase subunit interface; other site 402881002752 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 402881002753 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 402881002754 Walker A/P-loop; other site 402881002755 ATP binding site [chemical binding]; other site 402881002756 Q-loop/lid; other site 402881002757 ABC transporter signature motif; other site 402881002758 Walker B; other site 402881002759 D-loop; other site 402881002760 H-loop/switch region; other site 402881002761 NMT1/THI5 like; Region: NMT1; pfam09084 402881002762 Predicted integral membrane protein [Function unknown]; Region: COG5436 402881002763 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 402881002764 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 402881002765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 402881002766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 402881002767 Transglycosylase; Region: Transgly; pfam00912 402881002768 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 402881002769 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 402881002770 hypothetical protein; Provisional; Region: PRK05170 402881002771 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 402881002772 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 402881002773 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 402881002774 nudix motif; other site 402881002775 Uncharacterized conserved protein [Function unknown]; Region: COG5323 402881002776 Phage-related protein [Function unknown]; Region: COG4695 402881002777 Phage portal protein; Region: Phage_portal; pfam04860 402881002778 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 402881002779 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 402881002780 Phage capsid family; Region: Phage_capsid; pfam05065 402881002781 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 402881002782 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 402881002783 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 402881002784 oligomerization interface [polypeptide binding]; other site 402881002785 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 402881002786 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 402881002787 Phage major tail protein 2; Region: Phage_tail_2; cl11463 402881002788 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 402881002789 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774 402881002790 Phage-related minor tail protein [Function unknown]; Region: COG5281 402881002791 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 402881002792 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 402881002793 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 402881002794 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 402881002795 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 402881002796 NlpC/P60 family; Region: NLPC_P60; cl17555 402881002797 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 402881002798 Putative phage tail protein; Region: Phage-tail_3; pfam13550 402881002799 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 402881002800 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 402881002801 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 402881002802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881002803 NAD(P) binding site [chemical binding]; other site 402881002804 active site 402881002805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881002806 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002807 active site 402881002808 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 402881002809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881002811 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 402881002812 putative FMN binding site [chemical binding]; other site 402881002813 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 402881002814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881002815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881002816 active site 402881002817 phosphorylation site [posttranslational modification] 402881002818 intermolecular recognition site; other site 402881002819 dimerization interface [polypeptide binding]; other site 402881002820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881002821 DNA binding site [nucleotide binding] 402881002822 sensor protein PhoQ; Provisional; Region: PRK10815 402881002823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881002824 ATP binding site [chemical binding]; other site 402881002825 Mg2+ binding site [ion binding]; other site 402881002826 G-X-G motif; other site 402881002827 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 402881002828 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 402881002829 Rrf2 family protein; Region: rrf2_super; TIGR00738 402881002830 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 402881002831 DNA-binding site [nucleotide binding]; DNA binding site 402881002832 RNA-binding motif; other site 402881002833 D-cysteine desulfhydrase; Validated; Region: PRK03910 402881002834 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 402881002835 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881002836 catalytic residue [active] 402881002837 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 402881002838 CoA-transferase family III; Region: CoA_transf_3; pfam02515 402881002839 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881002840 PAS domain S-box; Region: sensory_box; TIGR00229 402881002841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881002842 putative active site [active] 402881002843 heme pocket [chemical binding]; other site 402881002844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881002845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881002846 dimer interface [polypeptide binding]; other site 402881002847 phosphorylation site [posttranslational modification] 402881002848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881002849 ATP binding site [chemical binding]; other site 402881002850 Mg2+ binding site [ion binding]; other site 402881002851 G-X-G motif; other site 402881002852 Penicillin amidase; Region: Penicil_amidase; pfam01804 402881002853 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 402881002854 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 402881002855 active site 402881002856 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 402881002857 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 402881002858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881002859 binding surface 402881002860 TPR motif; other site 402881002861 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 402881002862 catalytic residue [active] 402881002863 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 402881002864 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 402881002865 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 402881002866 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 402881002867 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 402881002868 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 402881002869 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 402881002870 protein binding site [polypeptide binding]; other site 402881002871 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 402881002872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881002873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881002874 active site 402881002875 phosphorylation site [posttranslational modification] 402881002876 intermolecular recognition site; other site 402881002877 dimerization interface [polypeptide binding]; other site 402881002878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881002879 DNA binding site [nucleotide binding] 402881002880 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 402881002881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 402881002882 dimerization interface [polypeptide binding]; other site 402881002883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881002884 ATP binding site [chemical binding]; other site 402881002885 Mg2+ binding site [ion binding]; other site 402881002886 G-X-G motif; other site 402881002887 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 402881002888 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 402881002889 metal binding triad; other site 402881002890 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 402881002891 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 402881002892 metal binding triad; other site 402881002893 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 402881002894 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 402881002895 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 402881002896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 402881002897 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 402881002898 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 402881002899 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 402881002900 Ca2+ binding site [ion binding]; other site 402881002901 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 402881002902 EF-hand domain pair; Region: EF_hand_5; pfam13499 402881002903 Ca2+ binding site [ion binding]; other site 402881002904 EF-hand domain pair; Region: EF_hand_5; pfam13499 402881002905 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 402881002906 Ca2+ binding site [ion binding]; other site 402881002907 RNA polymerase sigma factor; Reviewed; Region: PRK05602 402881002908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881002909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881002910 DNA binding residues [nucleotide binding] 402881002911 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 402881002912 dimer interface [polypeptide binding]; other site 402881002913 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 402881002914 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 402881002915 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 402881002916 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 402881002917 PAS fold; Region: PAS; pfam00989 402881002918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881002919 putative active site [active] 402881002920 heme pocket [chemical binding]; other site 402881002921 PAS fold; Region: PAS_7; pfam12860 402881002922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881002923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881002924 dimer interface [polypeptide binding]; other site 402881002925 phosphorylation site [posttranslational modification] 402881002926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881002927 ATP binding site [chemical binding]; other site 402881002928 Mg2+ binding site [ion binding]; other site 402881002929 G-X-G motif; other site 402881002930 aminopeptidase N; Provisional; Region: pepN; PRK14015 402881002931 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 402881002932 active site 402881002933 Zn binding site [ion binding]; other site 402881002934 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 402881002935 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 402881002936 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881002937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881002938 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881002939 MarR family; Region: MarR_2; pfam12802 402881002940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881002941 Beta-lactamase; Region: Beta-lactamase; pfam00144 402881002942 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 402881002943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002944 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 402881002945 active site 402881002946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881002947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881002948 active site 402881002949 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 402881002950 putative C-terminal domain interface [polypeptide binding]; other site 402881002951 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881002952 putative dimer interface [polypeptide binding]; other site 402881002953 putative GSH binding site (G-site) [chemical binding]; other site 402881002954 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 402881002955 dimer interface [polypeptide binding]; other site 402881002956 N-terminal domain interface [polypeptide binding]; other site 402881002957 putative substrate binding pocket (H-site) [chemical binding]; other site 402881002958 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 402881002959 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881002960 MarR family; Region: MarR_2; pfam12802 402881002961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881002962 S-adenosylmethionine binding site [chemical binding]; other site 402881002963 Predicted transcriptional regulator [Transcription]; Region: COG1959 402881002964 Transcriptional regulator; Region: Rrf2; pfam02082 402881002965 TIR domain; Region: TIR_2; pfam13676 402881002966 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 402881002967 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 402881002968 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 402881002969 HSP70 interaction site [polypeptide binding]; other site 402881002970 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 402881002971 substrate binding site [polypeptide binding]; other site 402881002972 dimer interface [polypeptide binding]; other site 402881002973 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 402881002974 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 402881002975 substrate binding pocket [chemical binding]; other site 402881002976 membrane-bound complex binding site; other site 402881002977 hinge residues; other site 402881002978 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881002979 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881002980 catalytic residue [active] 402881002981 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 402881002982 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881002983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881002984 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 402881002985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881002986 active site 402881002987 PhoD-like phosphatase; Region: PhoD; pfam09423 402881002988 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 402881002989 putative active site [active] 402881002990 putative metal binding site [ion binding]; other site 402881002991 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 402881002992 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 402881002993 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 402881002994 substrate binding site [chemical binding]; other site 402881002995 ATP binding site [chemical binding]; other site 402881002996 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 402881002997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881002998 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 402881002999 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 402881003000 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 402881003001 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 402881003002 putative active site [active] 402881003003 metal binding site [ion binding]; metal-binding site 402881003004 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 402881003005 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 402881003006 [2Fe-2S] cluster binding site [ion binding]; other site 402881003007 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 402881003008 putative alpha subunit interface [polypeptide binding]; other site 402881003009 putative active site [active] 402881003010 putative substrate binding site [chemical binding]; other site 402881003011 Fe binding site [ion binding]; other site 402881003012 Predicted flavoprotein [General function prediction only]; Region: COG0431 402881003013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 402881003014 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 402881003015 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881003016 short chain dehydrogenase; Provisional; Region: PRK06180 402881003017 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 402881003018 NADP binding site [chemical binding]; other site 402881003019 active site 402881003020 steroid binding site; other site 402881003021 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881003022 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 402881003023 active site 402881003024 iron coordination sites [ion binding]; other site 402881003025 substrate binding pocket [chemical binding]; other site 402881003026 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 402881003027 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 402881003028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881003030 putative substrate translocation pore; other site 402881003031 pyrimidine utilization protein A; Region: RutA; TIGR03612 402881003032 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 402881003033 active site 402881003034 dimer interface [polypeptide binding]; other site 402881003035 non-prolyl cis peptide bond; other site 402881003036 insertion regions; other site 402881003037 Isochorismatase family; Region: Isochorismatase; pfam00857 402881003038 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 402881003039 catalytic triad [active] 402881003040 conserved cis-peptide bond; other site 402881003041 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 402881003042 putative metal binding site [ion binding]; other site 402881003043 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 402881003044 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 402881003045 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 402881003046 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 402881003047 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 402881003048 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 402881003049 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 402881003050 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 402881003051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881003052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881003053 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 402881003054 substrate binding pocket [chemical binding]; other site 402881003055 dimerization interface [polypeptide binding]; other site 402881003056 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 402881003057 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003058 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003059 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003060 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 402881003061 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003062 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 402881003063 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003064 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 402881003065 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003066 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003067 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003068 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003069 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003070 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003071 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003072 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003073 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 402881003074 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003075 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 402881003076 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 402881003077 ligand binding surface [chemical binding]; other site 402881003078 VCBS repeat; Region: VCBS_repeat; TIGR01965 402881003079 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 402881003080 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 402881003081 putative active site [active] 402881003082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881003083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881003084 Walker A/P-loop; other site 402881003085 ATP binding site [chemical binding]; other site 402881003086 Q-loop/lid; other site 402881003087 ABC transporter signature motif; other site 402881003088 Walker B; other site 402881003089 D-loop; other site 402881003090 H-loop/switch region; other site 402881003091 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 402881003092 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881003093 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 402881003094 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 402881003095 NnrS protein; Region: NnrS; pfam05940 402881003096 Predicted integral membrane protein [Function unknown]; Region: COG5615 402881003097 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 402881003098 pseudoazurin; Region: pseudoazurin; TIGR02375 402881003099 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 402881003100 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 402881003101 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 402881003102 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 402881003103 ligand binding site [chemical binding]; other site 402881003104 flexible hinge region; other site 402881003105 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 402881003106 putative switch regulator; other site 402881003107 non-specific DNA interactions [nucleotide binding]; other site 402881003108 DNA binding site [nucleotide binding] 402881003109 sequence specific DNA binding site [nucleotide binding]; other site 402881003110 putative cAMP binding site [chemical binding]; other site 402881003111 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 402881003112 potassium-transporting ATPase subunit F; Provisional; Region: PRK14759 402881003113 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 402881003114 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881003115 Soluble P-type ATPase [General function prediction only]; Region: COG4087 402881003116 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 402881003117 K+-transporting ATPase, c chain; Region: KdpC; cl00944 402881003118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881003119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881003120 active site 402881003121 phosphorylation site [posttranslational modification] 402881003122 intermolecular recognition site; other site 402881003123 dimerization interface [polypeptide binding]; other site 402881003124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881003125 DNA binding site [nucleotide binding] 402881003126 enoyl-CoA hydratase; Provisional; Region: PRK08290 402881003127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881003128 substrate binding site [chemical binding]; other site 402881003129 oxyanion hole (OAH) forming residues; other site 402881003130 trimer interface [polypeptide binding]; other site 402881003131 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 402881003132 MFS/sugar transport protein; Region: MFS_2; pfam13347 402881003133 hypothetical protein; Provisional; Region: PRK06194 402881003134 classical (c) SDRs; Region: SDR_c; cd05233 402881003135 NAD(P) binding site [chemical binding]; other site 402881003136 active site 402881003137 hypothetical protein; Provisional; Region: PRK06194 402881003138 classical (c) SDRs; Region: SDR_c; cd05233 402881003139 NAD(P) binding site [chemical binding]; other site 402881003140 active site 402881003141 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 402881003142 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 402881003143 active site 402881003144 putative substrate binding pocket [chemical binding]; other site 402881003145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881003146 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 402881003147 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881003148 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 402881003149 NAD(P) binding site [chemical binding]; other site 402881003150 catalytic residues [active] 402881003151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881003152 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 402881003153 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881003154 putative AMP binding site [chemical binding]; other site 402881003155 putative active site [active] 402881003156 acyl-activating enzyme (AAE) consensus motif; other site 402881003157 putative CoA binding site [chemical binding]; other site 402881003158 lipid-transfer protein; Provisional; Region: PRK07855 402881003159 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 402881003160 active site 402881003161 DUF35 OB-fold domain; Region: DUF35; pfam01796 402881003162 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881003163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881003164 substrate binding site [chemical binding]; other site 402881003165 oxyanion hole (OAH) forming residues; other site 402881003166 trimer interface [polypeptide binding]; other site 402881003167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881003168 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 402881003169 acyl-activating enzyme (AAE) consensus motif; other site 402881003170 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881003171 putative AMP binding site [chemical binding]; other site 402881003172 putative active site [active] 402881003173 acyl-activating enzyme (AAE) consensus motif; other site 402881003174 putative CoA binding site [chemical binding]; other site 402881003175 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881003176 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881003177 active site 402881003178 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881003179 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881003180 active site 402881003181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881003182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881003183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 402881003184 dimerization interface [polypeptide binding]; other site 402881003185 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881003186 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 402881003187 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881003188 acyl-activating enzyme (AAE) consensus motif; other site 402881003189 acyl-activating enzyme (AAE) consensus motif; other site 402881003190 putative AMP binding site [chemical binding]; other site 402881003191 putative active site [active] 402881003192 putative CoA binding site [chemical binding]; other site 402881003193 choline dehydrogenase; Validated; Region: PRK02106 402881003194 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 402881003195 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 402881003196 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881003197 NAD(P) binding site [chemical binding]; other site 402881003198 catalytic residues [active] 402881003199 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 402881003200 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 402881003201 CoA-transferase family III; Region: CoA_transf_3; pfam02515 402881003202 RES domain; Region: RES; smart00953 402881003203 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 402881003204 Domain of unknown function DUF87; Region: DUF87; pfam01935 402881003205 HerA helicase [Replication, recombination, and repair]; Region: COG0433 402881003206 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 402881003207 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 402881003208 AAA domain; Region: AAA_23; pfam13476 402881003209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881003210 Walker A/P-loop; other site 402881003211 ATP binding site [chemical binding]; other site 402881003212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 402881003213 ABC transporter signature motif; other site 402881003214 Walker B; other site 402881003215 D-loop; other site 402881003216 H-loop/switch region; other site 402881003217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 402881003218 active site 402881003219 DNA binding site [nucleotide binding] 402881003220 Int/Topo IB signature motif; other site 402881003221 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 402881003222 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 402881003223 FMN binding site [chemical binding]; other site 402881003224 active site 402881003225 catalytic residues [active] 402881003226 substrate binding site [chemical binding]; other site 402881003227 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 402881003228 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 402881003229 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 402881003230 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 402881003231 active site 402881003232 substrate binding site [chemical binding]; other site 402881003233 metal binding site [ion binding]; metal-binding site 402881003234 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 402881003235 catalytic motif [active] 402881003236 Catalytic residue [active] 402881003237 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 402881003238 active site 402881003239 SAM binding site [chemical binding]; other site 402881003240 homodimer interface [polypeptide binding]; other site 402881003241 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 402881003242 PhnA protein; Region: PhnA; pfam03831 402881003243 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 402881003244 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 402881003245 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 402881003246 active site pocket [active] 402881003247 putative dimer interface [polypeptide binding]; other site 402881003248 putative cataytic base [active] 402881003249 Intracellular septation protein A; Region: IspA; cl01098 402881003250 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881003251 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 402881003252 FAD binding site [chemical binding]; other site 402881003253 substrate binding site [chemical binding]; other site 402881003254 catalytic base [active] 402881003255 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 402881003256 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 402881003257 active site 402881003258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881003259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881003260 dimer interface [polypeptide binding]; other site 402881003261 phosphorylation site [posttranslational modification] 402881003262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881003263 ATP binding site [chemical binding]; other site 402881003264 Mg2+ binding site [ion binding]; other site 402881003265 G-X-G motif; other site 402881003266 enoyl-CoA hydratase; Provisional; Region: PRK09245 402881003267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881003268 substrate binding site [chemical binding]; other site 402881003269 oxyanion hole (OAH) forming residues; other site 402881003270 trimer interface [polypeptide binding]; other site 402881003271 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 402881003272 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881003273 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881003274 active site 402881003275 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 402881003276 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 402881003277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881003278 dimer interface [polypeptide binding]; other site 402881003279 conserved gate region; other site 402881003280 putative PBP binding loops; other site 402881003281 ABC-ATPase subunit interface; other site 402881003282 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 402881003283 short chain dehydrogenase; Provisional; Region: PRK07791 402881003284 NAD binding site [chemical binding]; other site 402881003285 homodimer interface [polypeptide binding]; other site 402881003286 active site 402881003287 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 402881003288 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 402881003289 Nucleoside recognition; Region: Gate; pfam07670 402881003290 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 402881003291 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881003292 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 402881003293 putative C-terminal domain interface [polypeptide binding]; other site 402881003294 putative GSH binding site (G-site) [chemical binding]; other site 402881003295 putative dimer interface [polypeptide binding]; other site 402881003296 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881003297 N-terminal domain interface [polypeptide binding]; other site 402881003298 dimer interface [polypeptide binding]; other site 402881003299 substrate binding pocket (H-site) [chemical binding]; other site 402881003300 MFS/sugar transport protein; Region: MFS_2; pfam13347 402881003301 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 402881003302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881003303 dimerization interface [polypeptide binding]; other site 402881003304 putative DNA binding site [nucleotide binding]; other site 402881003305 putative Zn2+ binding site [ion binding]; other site 402881003306 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 402881003307 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 402881003308 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 402881003309 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 402881003310 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881003311 CoenzymeA binding site [chemical binding]; other site 402881003312 subunit interaction site [polypeptide binding]; other site 402881003313 PHB binding site; other site 402881003314 PAS domain; Region: PAS_5; pfam07310 402881003315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881003316 PAS domain; Region: PAS_5; pfam07310 402881003317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881003318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881003319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881003320 active site 402881003321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881003322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881003323 CAAX protease self-immunity; Region: Abi; pfam02517 402881003324 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 402881003325 putative uracil binding site [chemical binding]; other site 402881003326 putative active site [active] 402881003327 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 402881003328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881003329 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881003330 patatin-related protein; Region: TIGR03607 402881003331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881003332 putative active site [active] 402881003333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881003334 heme pocket [chemical binding]; other site 402881003335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881003336 dimer interface [polypeptide binding]; other site 402881003337 phosphorylation site [posttranslational modification] 402881003338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881003339 ATP binding site [chemical binding]; other site 402881003340 Mg2+ binding site [ion binding]; other site 402881003341 G-X-G motif; other site 402881003342 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 402881003343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881003344 active site 402881003345 phosphorylation site [posttranslational modification] 402881003346 intermolecular recognition site; other site 402881003347 dimerization interface [polypeptide binding]; other site 402881003348 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881003349 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881003350 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881003351 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 402881003352 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 402881003353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881003354 motif II; other site 402881003355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 402881003356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881003357 Coenzyme A binding pocket [chemical binding]; other site 402881003358 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 402881003359 putative active site [active] 402881003360 Zn binding site [ion binding]; other site 402881003361 succinic semialdehyde dehydrogenase; Region: PLN02278 402881003362 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 402881003363 tetramerization interface [polypeptide binding]; other site 402881003364 NAD(P) binding site [chemical binding]; other site 402881003365 catalytic residues [active] 402881003366 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 402881003367 tetramer (dimer of dimers) interface [polypeptide binding]; other site 402881003368 active site 402881003369 dimer interface [polypeptide binding]; other site 402881003370 glutathione reductase; Validated; Region: PRK06116 402881003371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881003372 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 402881003373 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 402881003374 Prostaglandin dehydrogenases; Region: PGDH; cd05288 402881003375 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 402881003376 NAD(P) binding site [chemical binding]; other site 402881003377 substrate binding site [chemical binding]; other site 402881003378 dimer interface [polypeptide binding]; other site 402881003379 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 402881003380 Prostaglandin dehydrogenases; Region: PGDH; cd05288 402881003381 NAD(P) binding site [chemical binding]; other site 402881003382 substrate binding site [chemical binding]; other site 402881003383 dimer interface [polypeptide binding]; other site 402881003384 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 402881003385 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 402881003386 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 402881003387 Walker A/P-loop; other site 402881003388 ATP binding site [chemical binding]; other site 402881003389 Q-loop/lid; other site 402881003390 ABC transporter signature motif; other site 402881003391 Walker B; other site 402881003392 D-loop; other site 402881003393 H-loop/switch region; other site 402881003394 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 402881003395 FtsX-like permease family; Region: FtsX; pfam02687 402881003396 macrolide transporter subunit MacA; Provisional; Region: PRK11578 402881003397 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881003398 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881003399 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 402881003400 Prostaglandin dehydrogenases; Region: PGDH; cd05288 402881003401 NAD(P) binding site [chemical binding]; other site 402881003402 substrate binding site [chemical binding]; other site 402881003403 dimer interface [polypeptide binding]; other site 402881003404 NAD synthetase; Provisional; Region: PRK13981 402881003405 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 402881003406 multimer interface [polypeptide binding]; other site 402881003407 active site 402881003408 catalytic triad [active] 402881003409 protein interface 1 [polypeptide binding]; other site 402881003410 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 402881003411 homodimer interface [polypeptide binding]; other site 402881003412 NAD binding pocket [chemical binding]; other site 402881003413 ATP binding pocket [chemical binding]; other site 402881003414 Mg binding site [ion binding]; other site 402881003415 active-site loop [active] 402881003416 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 402881003417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 402881003418 active site 402881003419 HIGH motif; other site 402881003420 nucleotide binding site [chemical binding]; other site 402881003421 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 402881003422 active site 402881003423 KMSKS motif; other site 402881003424 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 402881003425 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 402881003426 active site 402881003427 catalytic residues [active] 402881003428 metal binding site [ion binding]; metal-binding site 402881003429 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 402881003430 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 402881003431 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 402881003432 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 402881003433 Cupin; Region: Cupin_6; pfam12852 402881003434 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 402881003435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881003436 rarD protein; Region: rarD; TIGR00688 402881003437 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 402881003438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 402881003439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881003440 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 402881003441 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 402881003442 Walker A/P-loop; other site 402881003443 ATP binding site [chemical binding]; other site 402881003444 Q-loop/lid; other site 402881003445 ABC transporter signature motif; other site 402881003446 Walker B; other site 402881003447 D-loop; other site 402881003448 H-loop/switch region; other site 402881003449 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 402881003450 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 402881003451 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 402881003452 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 402881003453 phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098 402881003454 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 402881003455 PilZ domain; Region: PilZ; pfam07238 402881003456 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 402881003457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881003458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881003459 dimer interface [polypeptide binding]; other site 402881003460 phosphorylation site [posttranslational modification] 402881003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881003462 ATP binding site [chemical binding]; other site 402881003463 Mg2+ binding site [ion binding]; other site 402881003464 G-X-G motif; other site 402881003465 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 402881003466 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 402881003467 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 402881003468 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 402881003469 NAD(P) binding site [chemical binding]; other site 402881003470 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 402881003471 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881003472 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881003473 substrate binding site [chemical binding]; other site 402881003474 oxyanion hole (OAH) forming residues; other site 402881003475 trimer interface [polypeptide binding]; other site 402881003476 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 402881003477 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 402881003478 active site 402881003479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881003480 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881003481 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 402881003482 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 402881003483 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 402881003484 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 402881003485 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 402881003486 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 402881003487 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 402881003488 TAP-like protein; Region: Abhydrolase_4; pfam08386 402881003489 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881003490 Sulfatase; Region: Sulfatase; pfam00884 402881003491 Uncharacterized conserved protein [Function unknown]; Region: COG1262 402881003492 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 402881003493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 402881003494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881003495 ATP binding site [chemical binding]; other site 402881003496 Mg2+ binding site [ion binding]; other site 402881003497 G-X-G motif; other site 402881003498 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881003499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881003500 active site 402881003501 phosphorylation site [posttranslational modification] 402881003502 intermolecular recognition site; other site 402881003503 dimerization interface [polypeptide binding]; other site 402881003504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881003505 DNA binding residues [nucleotide binding] 402881003506 dimerization interface [polypeptide binding]; other site 402881003507 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 402881003508 Amidohydrolase; Region: Amidohydro_2; pfam04909 402881003509 short chain dehydrogenase; Provisional; Region: PRK06172 402881003510 classical (c) SDRs; Region: SDR_c; cd05233 402881003511 NAD(P) binding site [chemical binding]; other site 402881003512 active site 402881003513 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881003514 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 402881003515 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 402881003516 putative active site [active] 402881003517 catalytic site [active] 402881003518 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 402881003519 putative active site [active] 402881003520 catalytic site [active] 402881003521 Uncharacterized conserved protein [Function unknown]; Region: COG0398 402881003522 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 402881003523 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 402881003524 putative catalytic site [active] 402881003525 putative metal binding site [ion binding]; other site 402881003526 putative phosphate binding site [ion binding]; other site 402881003527 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 402881003528 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 402881003529 putative active site; other site 402881003530 catalytic triad [active] 402881003531 putative dimer interface [polypeptide binding]; other site 402881003532 putrescine carbamoyltransferase; Provisional; Region: PRK02255 402881003533 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 402881003534 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 402881003535 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 402881003536 agmatine deiminase; Provisional; Region: PRK13551 402881003537 agmatine deiminase; Region: agmatine_aguA; TIGR03380 402881003538 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 402881003539 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 402881003540 putative substrate binding site [chemical binding]; other site 402881003541 nucleotide binding site [chemical binding]; other site 402881003542 nucleotide binding site [chemical binding]; other site 402881003543 homodimer interface [polypeptide binding]; other site 402881003544 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 402881003545 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 402881003546 Prostaglandin dehydrogenases; Region: PGDH; cd05288 402881003547 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 402881003548 NAD(P) binding site [chemical binding]; other site 402881003549 substrate binding site [chemical binding]; other site 402881003550 dimer interface [polypeptide binding]; other site 402881003551 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 402881003552 Walker A motif; other site 402881003553 ATP binding site [chemical binding]; other site 402881003554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881003555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881003556 DNA binding residues [nucleotide binding] 402881003557 dimerization interface [polypeptide binding]; other site 402881003558 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 402881003559 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 402881003560 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 402881003561 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 402881003562 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 402881003563 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 402881003564 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 402881003565 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 402881003566 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 402881003567 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 402881003568 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 402881003569 acyl-activating enzyme (AAE) consensus motif; other site 402881003570 putative AMP binding site [chemical binding]; other site 402881003571 putative active site [active] 402881003572 putative CoA binding site [chemical binding]; other site 402881003573 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 402881003574 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 402881003575 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 402881003576 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 402881003577 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 402881003578 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 402881003579 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 402881003580 DctM-like transporters; Region: DctM; pfam06808 402881003581 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 402881003582 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 402881003583 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881003584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881003585 exopolyphosphatase; Region: exo_poly_only; TIGR03706 402881003586 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 402881003587 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 402881003588 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 402881003589 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 402881003590 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 402881003591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 402881003592 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 402881003593 active site 402881003594 16S rRNA methyltransferase B; Provisional; Region: PRK10901 402881003595 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 402881003596 TPR repeat; Region: TPR_11; pfam13414 402881003597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881003598 TPR motif; other site 402881003599 binding surface 402881003600 Tetratricopeptide repeat; Region: TPR_16; pfam13432 402881003601 GMP synthase; Reviewed; Region: guaA; PRK00074 402881003602 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 402881003603 AMP/PPi binding site [chemical binding]; other site 402881003604 candidate oxyanion hole; other site 402881003605 catalytic triad [active] 402881003606 potential glutamine specificity residues [chemical binding]; other site 402881003607 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 402881003608 ATP Binding subdomain [chemical binding]; other site 402881003609 Ligand Binding sites [chemical binding]; other site 402881003610 Dimerization subdomain; other site 402881003611 integrase; Provisional; Region: PRK09692 402881003612 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 402881003613 active site 402881003614 Int/Topo IB signature motif; other site 402881003615 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 402881003616 PglZ domain; Region: PglZ; pfam08665 402881003617 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 402881003618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881003619 ATP binding site [chemical binding]; other site 402881003620 putative Mg++ binding site [ion binding]; other site 402881003621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881003622 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 402881003623 nucleotide binding region [chemical binding]; other site 402881003624 ATP-binding site [chemical binding]; other site 402881003625 DNA methylase; Region: N6_N4_Mtase; cl17433 402881003626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881003627 ATP binding site [chemical binding]; other site 402881003628 Mg2+ binding site [ion binding]; other site 402881003629 G-X-G motif; other site 402881003630 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 402881003631 Divergent AAA domain; Region: AAA_4; pfam04326 402881003632 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 402881003633 Helix-turn-helix domain; Region: HTH_17; pfam12728 402881003634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881003635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881003636 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 402881003637 dimerization interface [polypeptide binding]; other site 402881003638 substrate binding pocket [chemical binding]; other site 402881003639 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 402881003640 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 402881003641 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 402881003642 VirB7 interaction site; other site 402881003643 conjugal transfer protein TrbF; Provisional; Region: PRK13872 402881003644 conjugal transfer protein TrbL; Provisional; Region: PRK13875 402881003645 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 402881003646 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 402881003647 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 402881003648 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 402881003649 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 402881003650 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 402881003651 Walker A motif; other site 402881003652 ATP binding site [chemical binding]; other site 402881003653 Walker B motif; other site 402881003654 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 402881003655 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 402881003656 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 402881003657 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 402881003658 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 402881003659 Walker A motif; other site 402881003660 ATP binding site [chemical binding]; other site 402881003661 Walker B motif; other site 402881003662 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 402881003663 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 402881003664 Walker A motif; other site 402881003665 ATP binding site [chemical binding]; other site 402881003666 Walker B motif; other site 402881003667 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 402881003668 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 402881003669 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 402881003670 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881003671 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881003672 catalytic residue [active] 402881003673 Protein of unknown function (DUF736); Region: DUF736; pfam05284 402881003674 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 402881003675 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 402881003676 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 402881003677 ParA-like protein; Provisional; Region: PHA02518 402881003678 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881003679 P-loop; other site 402881003680 Magnesium ion binding site [ion binding]; other site 402881003681 Replication initiator protein A; Region: RPA; pfam10134 402881003682 Helix-turn-helix domain; Region: HTH_17; pfam12728 402881003683 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 402881003684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 402881003685 Uncharacterized conserved protein [Function unknown]; Region: COG5489 402881003686 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 402881003687 oligomeric interface; other site 402881003688 putative active site [active] 402881003689 homodimer interface [polypeptide binding]; other site 402881003690 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 402881003691 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 402881003692 Toprim domain; Region: Toprim_3; pfam13362 402881003693 Methyltransferase domain; Region: Methyltransf_26; pfam13659 402881003694 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 402881003695 Helicase_C-like; Region: Helicase_C_4; pfam13871 402881003696 ParB-like nuclease domain; Region: ParB; smart00470 402881003697 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 402881003698 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 402881003699 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 402881003700 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 402881003701 AAA domain; Region: AAA_30; pfam13604 402881003702 Family description; Region: UvrD_C_2; pfam13538 402881003703 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 402881003704 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 402881003705 substrate binding site [chemical binding]; other site 402881003706 ATP binding site [chemical binding]; other site 402881003707 pantothenate kinase; Provisional; Region: PRK05439 402881003708 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 402881003709 ATP-binding site [chemical binding]; other site 402881003710 CoA-binding site [chemical binding]; other site 402881003711 Mg2+-binding site [ion binding]; other site 402881003712 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 402881003713 metal binding site [ion binding]; metal-binding site 402881003714 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881003715 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 402881003716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881003717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881003718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881003719 Uncharacterized conserved protein [Function unknown]; Region: COG3025 402881003720 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 402881003721 putative active site [active] 402881003722 putative metal binding residues [ion binding]; other site 402881003723 signature motif; other site 402881003724 putative triphosphate binding site [ion binding]; other site 402881003725 CHAD domain; Region: CHAD; pfam05235 402881003726 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 402881003727 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 402881003728 substrate binding site [chemical binding]; other site 402881003729 glutamase interaction surface [polypeptide binding]; other site 402881003730 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 402881003731 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 402881003732 catalytic residues [active] 402881003733 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 402881003734 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 402881003735 putative active site [active] 402881003736 oxyanion strand; other site 402881003737 catalytic triad [active] 402881003738 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 402881003739 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 402881003740 putative active site pocket [active] 402881003741 4-fold oligomerization interface [polypeptide binding]; other site 402881003742 metal binding residues [ion binding]; metal-binding site 402881003743 3-fold/trimer interface [polypeptide binding]; other site 402881003744 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 402881003745 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 402881003746 active site 402881003747 HslU subunit interaction site [polypeptide binding]; other site 402881003748 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 402881003749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881003750 Walker A motif; other site 402881003751 ATP binding site [chemical binding]; other site 402881003752 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 402881003753 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 402881003754 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 402881003755 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 402881003756 oxidase reductase; Provisional; Region: PTZ00273 402881003757 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 402881003758 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 402881003759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881003760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881003761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 402881003762 dimerization interface [polypeptide binding]; other site 402881003763 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881003764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881003765 sequence-specific DNA binding site [nucleotide binding]; other site 402881003766 salt bridge; other site 402881003767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 402881003768 Smr domain; Region: Smr; pfam01713 402881003769 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 402881003770 MltA specific insert domain; Region: MltA; smart00925 402881003771 3D domain; Region: 3D; pfam06725 402881003772 Tim44-like domain; Region: Tim44; pfam04280 402881003773 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 402881003774 preprotein translocase subunit SecB; Validated; Region: PRK05751 402881003775 SecA binding site; other site 402881003776 Preprotein binding site; other site 402881003777 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 402881003778 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 402881003779 active site 402881003780 catalytic site [active] 402881003781 substrate binding site [chemical binding]; other site 402881003782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881003783 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 402881003784 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 402881003785 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 402881003786 CoA-binding site [chemical binding]; other site 402881003787 ATP-binding [chemical binding]; other site 402881003788 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 402881003789 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 402881003790 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 402881003791 shikimate binding site; other site 402881003792 NAD(P) binding site [chemical binding]; other site 402881003793 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 402881003794 putative active site [active] 402881003795 PEP synthetase regulatory protein; Provisional; Region: PRK05339 402881003796 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 402881003797 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 402881003798 substrate binding site [chemical binding]; other site 402881003799 active site 402881003800 Ferrochelatase; Region: Ferrochelatase; pfam00762 402881003801 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 402881003802 C-terminal domain interface [polypeptide binding]; other site 402881003803 active site 402881003804 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 402881003805 active site 402881003806 N-terminal domain interface [polypeptide binding]; other site 402881003807 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 402881003808 transcription termination factor Rho; Provisional; Region: rho; PRK09376 402881003809 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 402881003810 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 402881003811 RNA binding site [nucleotide binding]; other site 402881003812 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 402881003813 multimer interface [polypeptide binding]; other site 402881003814 Walker A motif; other site 402881003815 ATP binding site [chemical binding]; other site 402881003816 Walker B motif; other site 402881003817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881003818 PAS domain; Region: PAS_5; pfam07310 402881003819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881003820 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 402881003821 catalytic site [active] 402881003822 Uncharacterized conserved protein [Function unknown]; Region: COG3791 402881003823 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 402881003824 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 402881003825 NADP binding site [chemical binding]; other site 402881003826 dimer interface [polypeptide binding]; other site 402881003827 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 402881003828 Dienelactone hydrolase family; Region: DLH; pfam01738 402881003829 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 402881003830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881003831 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 402881003832 dimerization interface [polypeptide binding]; other site 402881003833 substrate binding pocket [chemical binding]; other site 402881003834 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 402881003835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881003836 Coenzyme A binding pocket [chemical binding]; other site 402881003837 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 402881003838 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 402881003839 catalytic residues [active] 402881003840 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 402881003841 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 402881003842 trmE is a tRNA modification GTPase; Region: trmE; cd04164 402881003843 G1 box; other site 402881003844 GTP/Mg2+ binding site [chemical binding]; other site 402881003845 Switch I region; other site 402881003846 G2 box; other site 402881003847 Switch II region; other site 402881003848 G3 box; other site 402881003849 G4 box; other site 402881003850 G5 box; other site 402881003851 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 402881003852 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 402881003853 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 402881003854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881003855 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 402881003856 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 402881003857 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 402881003858 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 402881003859 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 402881003860 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881003861 P-loop; other site 402881003862 Magnesium ion binding site [ion binding]; other site 402881003863 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881003864 Magnesium ion binding site [ion binding]; other site 402881003865 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 402881003866 ParB-like nuclease domain; Region: ParBc; pfam02195 402881003867 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 402881003868 Lipopolysaccharide-assembly; Region: LptE; cl01125 402881003869 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 402881003870 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 402881003871 HIGH motif; other site 402881003872 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 402881003873 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 402881003874 active site 402881003875 KMSKS motif; other site 402881003876 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 402881003877 tRNA binding surface [nucleotide binding]; other site 402881003878 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 402881003879 Gram-negative porin; Region: Porin_4; pfam13609 402881003880 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 402881003881 sulfotransferase; Region: PLN02164 402881003882 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 402881003883 active site 402881003884 pyrophosphate binding site [ion binding]; other site 402881003885 thiamine phosphate binding site [chemical binding]; other site 402881003886 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 402881003887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 402881003888 catalytic residue [active] 402881003889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 402881003890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881003891 TPR repeat; Region: TPR_11; pfam13414 402881003892 binding surface 402881003893 TPR motif; other site 402881003894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881003895 binding surface 402881003896 TPR repeat; Region: TPR_11; pfam13414 402881003897 TPR motif; other site 402881003898 TPR repeat; Region: TPR_11; pfam13414 402881003899 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 402881003900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881003901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881003902 active site 402881003903 phosphorylation site [posttranslational modification] 402881003904 intermolecular recognition site; other site 402881003905 dimerization interface [polypeptide binding]; other site 402881003906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881003907 DNA binding site [nucleotide binding] 402881003908 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881003909 active site 402881003910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 402881003911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 402881003912 ligand binding site [chemical binding]; other site 402881003913 flexible hinge region; other site 402881003914 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881003915 CoenzymeA binding site [chemical binding]; other site 402881003916 subunit interaction site [polypeptide binding]; other site 402881003917 PHB binding site; other site 402881003918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881003919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881003920 Bacterial transcriptional repressor; Region: TetR; pfam13972 402881003921 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 402881003922 putative catalytic site [active] 402881003923 putative phosphate binding site [ion binding]; other site 402881003924 active site 402881003925 metal binding site A [ion binding]; metal-binding site 402881003926 DNA binding site [nucleotide binding] 402881003927 putative AP binding site [nucleotide binding]; other site 402881003928 putative metal binding site B [ion binding]; other site 402881003929 putative aminotransferase; Validated; Region: PRK07480 402881003930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 402881003931 inhibitor-cofactor binding pocket; inhibition site 402881003932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881003933 catalytic residue [active] 402881003934 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 402881003935 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 402881003936 Peptidase C26; Region: Peptidase_C26; pfam07722 402881003937 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 402881003938 catalytic triad [active] 402881003939 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 402881003940 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 402881003941 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 402881003942 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 402881003943 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 402881003944 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 402881003945 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 402881003946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881003947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881003948 homodimer interface [polypeptide binding]; other site 402881003949 catalytic residue [active] 402881003950 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 402881003951 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 402881003952 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 402881003953 Nitrogen regulatory protein P-II; Region: P-II; smart00938 402881003954 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 402881003955 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 402881003956 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 402881003957 Trp docking motif [polypeptide binding]; other site 402881003958 cytochrome domain interface [polypeptide binding]; other site 402881003959 active site 402881003960 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 402881003961 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 402881003962 amidase; Provisional; Region: PRK07056 402881003963 Amidase; Region: Amidase; cl11426 402881003964 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 402881003965 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881003966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 402881003967 Uncharacterized conserved protein [Function unknown]; Region: COG2835 402881003968 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 402881003969 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 402881003970 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 402881003971 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 402881003972 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 402881003973 putative deacylase active site [active] 402881003974 hypothetical protein; Provisional; Region: PRK02250 402881003975 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 402881003976 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 402881003977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881003978 Methyltransferase domain; Region: Methyltransf_24; pfam13578 402881003979 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 402881003980 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 402881003981 purine monophosphate binding site [chemical binding]; other site 402881003982 dimer interface [polypeptide binding]; other site 402881003983 putative catalytic residues [active] 402881003984 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 402881003985 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 402881003986 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881003987 CoenzymeA binding site [chemical binding]; other site 402881003988 subunit interaction site [polypeptide binding]; other site 402881003989 PHB binding site; other site 402881003990 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 402881003991 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 402881003992 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 402881003993 substrate binding site [chemical binding]; other site 402881003994 hexamer interface [polypeptide binding]; other site 402881003995 metal binding site [ion binding]; metal-binding site 402881003996 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 402881003997 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881003999 S-adenosylmethionine binding site [chemical binding]; other site 402881004000 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881004001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881004002 S-adenosylmethionine binding site [chemical binding]; other site 402881004003 16S rRNA methyltransferase B; Provisional; Region: PRK10901 402881004004 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 402881004005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881004006 S-adenosylmethionine binding site [chemical binding]; other site 402881004007 Peptidase family M48; Region: Peptidase_M48; cl12018 402881004008 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 402881004009 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 402881004010 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 402881004011 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 402881004012 Catalytic site; other site 402881004013 acetyl-CoA synthetase; Provisional; Region: PRK00174 402881004014 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 402881004015 active site 402881004016 CoA binding site [chemical binding]; other site 402881004017 acyl-activating enzyme (AAE) consensus motif; other site 402881004018 AMP binding site [chemical binding]; other site 402881004019 acetate binding site [chemical binding]; other site 402881004020 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 402881004021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 402881004022 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 402881004023 CoA-transferase family III; Region: CoA_transf_3; pfam02515 402881004024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 402881004025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881004026 Coenzyme A binding pocket [chemical binding]; other site 402881004027 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 402881004028 Creatinine amidohydrolase; Region: Creatininase; pfam02633 402881004029 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 402881004030 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 402881004031 metal binding site [ion binding]; metal-binding site 402881004032 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 402881004033 iron-sulfur cluster [ion binding]; other site 402881004034 [2Fe-2S] cluster binding site [ion binding]; other site 402881004035 EVE domain; Region: EVE; pfam01878 402881004036 YciI-like protein; Reviewed; Region: PRK12863 402881004037 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 402881004038 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 402881004039 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 402881004040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004042 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 402881004043 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881004044 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881004045 UGMP family protein; Validated; Region: PRK09604 402881004046 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 402881004047 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 402881004048 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 402881004049 domain interfaces; other site 402881004050 active site 402881004051 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 402881004052 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 402881004053 active site 402881004054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 402881004055 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 402881004056 HemY protein N-terminus; Region: HemY_N; pfam07219 402881004057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881004058 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 402881004059 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 402881004060 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 402881004061 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 402881004062 Nitrogen regulatory protein P-II; Region: P-II; smart00938 402881004063 CoA-transferase family III; Region: CoA_transf_3; pfam02515 402881004064 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 402881004065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881004066 dimer interface [polypeptide binding]; other site 402881004067 phosphorylation site [posttranslational modification] 402881004068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881004069 ATP binding site [chemical binding]; other site 402881004070 Mg2+ binding site [ion binding]; other site 402881004071 G-X-G motif; other site 402881004072 Domain of unknown function DUF87; Region: DUF87; pfam01935 402881004073 AAA-like domain; Region: AAA_10; pfam12846 402881004074 Protein of unknown function (DUF461); Region: DUF461; pfam04314 402881004075 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 402881004076 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 402881004077 GIY-YIG motif/motif A; other site 402881004078 putative active site [active] 402881004079 putative metal binding site [ion binding]; other site 402881004080 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 402881004081 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 402881004082 Asp-box motif; other site 402881004083 enoyl-CoA hydratase; Provisional; Region: PRK06688 402881004084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881004085 substrate binding site [chemical binding]; other site 402881004086 oxyanion hole (OAH) forming residues; other site 402881004087 trimer interface [polypeptide binding]; other site 402881004088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881004089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881004090 active site 402881004091 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881004092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881004093 active site 402881004094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004095 short chain dehydrogenase; Validated; Region: PRK07069 402881004096 NAD(P) binding site [chemical binding]; other site 402881004097 active site 402881004098 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 402881004099 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 402881004100 catalytic triad [active] 402881004101 YGGT family; Region: YGGT; pfam02325 402881004102 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 402881004103 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 402881004104 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 402881004105 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 402881004106 homodimer interface [polypeptide binding]; other site 402881004107 NADP binding site [chemical binding]; other site 402881004108 substrate binding site [chemical binding]; other site 402881004109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 402881004110 active site 402881004111 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 402881004112 catalytic tetrad [active] 402881004113 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 402881004114 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 402881004115 Beta-lactamase; Region: Beta-lactamase; pfam00144 402881004116 Beta-lactamase; Region: Beta-lactamase; cl17358 402881004117 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 402881004118 dimer interface [polypeptide binding]; other site 402881004119 substrate binding site [chemical binding]; other site 402881004120 metal binding sites [ion binding]; metal-binding site 402881004121 argininosuccinate synthase; Provisional; Region: PRK13820 402881004122 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 402881004123 ANP binding site [chemical binding]; other site 402881004124 Substrate Binding Site II [chemical binding]; other site 402881004125 Substrate Binding Site I [chemical binding]; other site 402881004126 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 402881004127 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 402881004128 putative catalytic residue [active] 402881004129 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 402881004130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881004131 FeS/SAM binding site; other site 402881004132 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 402881004133 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 402881004134 NAD(P) binding site [chemical binding]; other site 402881004135 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 402881004136 active site 402881004137 catalytic triad [active] 402881004138 oxyanion hole [active] 402881004139 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 402881004140 Beta-lactamase; Region: Beta-lactamase; pfam00144 402881004141 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 402881004142 Uncharacterized conserved protein [Function unknown]; Region: COG3339 402881004143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004144 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 402881004145 NAD(P) binding site [chemical binding]; other site 402881004146 active site 402881004147 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 402881004148 aromatic arch; other site 402881004149 DCoH dimer interaction site [polypeptide binding]; other site 402881004150 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 402881004151 DCoH tetramer interaction site [polypeptide binding]; other site 402881004152 substrate binding site [chemical binding]; other site 402881004153 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 402881004154 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 402881004155 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 402881004156 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 402881004157 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 402881004158 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 402881004159 active site 402881004160 catalytic tetrad [active] 402881004161 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 402881004162 active site 402881004163 catalytic triad [active] 402881004164 oxyanion hole [active] 402881004165 switch loop; other site 402881004166 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 402881004167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 402881004168 Walker A/P-loop; other site 402881004169 ATP binding site [chemical binding]; other site 402881004170 Q-loop/lid; other site 402881004171 ABC transporter signature motif; other site 402881004172 Walker B; other site 402881004173 D-loop; other site 402881004174 H-loop/switch region; other site 402881004175 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 402881004176 FtsX-like permease family; Region: FtsX; pfam02687 402881004177 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 402881004178 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 402881004179 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 402881004180 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 402881004181 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 402881004182 Walker A/P-loop; other site 402881004183 ATP binding site [chemical binding]; other site 402881004184 Q-loop/lid; other site 402881004185 ABC transporter signature motif; other site 402881004186 Walker B; other site 402881004187 D-loop; other site 402881004188 H-loop/switch region; other site 402881004189 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 402881004190 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 402881004191 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 402881004192 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 402881004193 aconitate hydratase; Validated; Region: PRK09277 402881004194 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 402881004195 substrate binding site [chemical binding]; other site 402881004196 ligand binding site [chemical binding]; other site 402881004197 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 402881004198 substrate binding site [chemical binding]; other site 402881004199 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881004200 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881004201 substrate binding site [chemical binding]; other site 402881004202 oxyanion hole (OAH) forming residues; other site 402881004203 trimer interface [polypeptide binding]; other site 402881004204 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 402881004205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881004206 Walker A/P-loop; other site 402881004207 ATP binding site [chemical binding]; other site 402881004208 Q-loop/lid; other site 402881004209 ABC transporter signature motif; other site 402881004210 Walker B; other site 402881004211 D-loop; other site 402881004212 H-loop/switch region; other site 402881004213 heme exporter protein CcmB; Region: ccmB; TIGR01190 402881004214 heme exporter protein CcmC; Region: ccmC; TIGR01191 402881004215 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 402881004216 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 402881004217 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 402881004218 catalytic residues [active] 402881004219 central insert; other site 402881004220 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881004221 MarR family; Region: MarR_2; pfam12802 402881004222 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 402881004223 nudix motif; other site 402881004224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881004225 putative substrate translocation pore; other site 402881004226 Intracellular septation protein A; Region: IspA; pfam04279 402881004227 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 402881004228 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 402881004229 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 402881004230 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 402881004231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881004232 FeS/SAM binding site; other site 402881004233 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 402881004234 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 402881004235 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 402881004236 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 402881004237 Competence-damaged protein; Region: CinA; pfam02464 402881004238 signal recognition particle protein; Provisional; Region: PRK10867 402881004239 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 402881004240 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 402881004241 P loop; other site 402881004242 GTP binding site [chemical binding]; other site 402881004243 Signal peptide binding domain; Region: SRP_SPB; pfam02978 402881004244 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 402881004245 RimM N-terminal domain; Region: RimM; pfam01782 402881004246 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 402881004247 PRC-barrel domain; Region: PRC; pfam05239 402881004248 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 402881004249 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 402881004250 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 402881004251 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 402881004252 substrate binding site [chemical binding]; other site 402881004253 ligand binding site [chemical binding]; other site 402881004254 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 402881004255 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 402881004256 substrate binding site [chemical binding]; other site 402881004257 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 402881004258 tartrate dehydrogenase; Region: TTC; TIGR02089 402881004259 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 402881004260 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 402881004261 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 402881004262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881004263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881004264 dimer interface [polypeptide binding]; other site 402881004265 phosphorylation site [posttranslational modification] 402881004266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881004267 ATP binding site [chemical binding]; other site 402881004268 Mg2+ binding site [ion binding]; other site 402881004269 G-X-G motif; other site 402881004270 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 402881004271 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 402881004272 putative active site [active] 402881004273 putative catalytic site [active] 402881004274 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 402881004275 putative active site [active] 402881004276 putative catalytic site [active] 402881004277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881004278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881004279 CoenzymeA binding site [chemical binding]; other site 402881004280 subunit interaction site [polypeptide binding]; other site 402881004281 PHB binding site; other site 402881004282 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 402881004283 Iron-sulfur protein interface; other site 402881004284 proximal quinone binding site [chemical binding]; other site 402881004285 SdhD (CybS) interface [polypeptide binding]; other site 402881004286 proximal heme binding site [chemical binding]; other site 402881004287 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 402881004288 putative SdhC subunit interface [polypeptide binding]; other site 402881004289 putative proximal heme binding site [chemical binding]; other site 402881004290 putative Iron-sulfur protein interface [polypeptide binding]; other site 402881004291 putative proximal quinone binding site; other site 402881004292 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 402881004293 L-aspartate oxidase; Provisional; Region: PRK06175 402881004294 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 402881004295 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 402881004296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881004297 catalytic loop [active] 402881004298 iron binding site [ion binding]; other site 402881004299 Uncharacterized conserved protein [Function unknown]; Region: COG1359 402881004300 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881004301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881004302 putative DNA binding site [nucleotide binding]; other site 402881004303 putative Zn2+ binding site [ion binding]; other site 402881004304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 402881004305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881004306 putative metal binding site [ion binding]; other site 402881004307 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 402881004308 Low molecular weight phosphatase family; Region: LMWPc; cd00115 402881004309 active site 402881004310 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 402881004311 arsenical-resistance protein; Region: acr3; TIGR00832 402881004312 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 402881004313 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 402881004314 tetrameric interface [polypeptide binding]; other site 402881004315 NAD binding site [chemical binding]; other site 402881004316 catalytic residues [active] 402881004317 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 402881004318 Predicted ATPase [General function prediction only]; Region: COG1485 402881004319 malate dehydrogenase; Reviewed; Region: PRK06223 402881004320 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 402881004321 NAD(P) binding site [chemical binding]; other site 402881004322 dimer interface [polypeptide binding]; other site 402881004323 tetramer (dimer of dimers) interface [polypeptide binding]; other site 402881004324 substrate binding site [chemical binding]; other site 402881004325 ribonuclease Z; Reviewed; Region: PRK00055 402881004326 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 402881004327 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 402881004328 CoA-ligase; Region: Ligase_CoA; pfam00549 402881004329 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 402881004330 CoA binding domain; Region: CoA_binding; smart00881 402881004331 CoA-ligase; Region: Ligase_CoA; pfam00549 402881004332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881004333 non-specific DNA binding site [nucleotide binding]; other site 402881004334 salt bridge; other site 402881004335 sequence-specific DNA binding site [nucleotide binding]; other site 402881004336 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 402881004337 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 402881004338 TPP-binding site [chemical binding]; other site 402881004339 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 402881004340 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 402881004341 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 402881004342 E3 interaction surface; other site 402881004343 lipoyl attachment site [posttranslational modification]; other site 402881004344 e3 binding domain; Region: E3_binding; pfam02817 402881004345 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 402881004346 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 402881004347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 402881004348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881004349 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 402881004350 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 402881004351 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 402881004352 active site 402881004353 DNA binding site [nucleotide binding] 402881004354 Int/Topo IB signature motif; other site 402881004355 Protein of unknown function, DUF484; Region: DUF484; cl17449 402881004356 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 402881004357 active site 402881004358 intersubunit interactions; other site 402881004359 catalytic residue [active] 402881004360 primosome assembly protein PriA; Validated; Region: PRK05580 402881004361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881004362 ATP binding site [chemical binding]; other site 402881004363 putative Mg++ binding site [ion binding]; other site 402881004364 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 402881004365 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 402881004366 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 402881004367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 402881004368 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 402881004369 beta subunit interaction interface [polypeptide binding]; other site 402881004370 Walker A motif; other site 402881004371 ATP binding site [chemical binding]; other site 402881004372 Walker B motif; other site 402881004373 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 402881004374 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 402881004375 core domain interface [polypeptide binding]; other site 402881004376 delta subunit interface [polypeptide binding]; other site 402881004377 epsilon subunit interface [polypeptide binding]; other site 402881004378 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 402881004379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 402881004380 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 402881004381 alpha subunit interaction interface [polypeptide binding]; other site 402881004382 Walker A motif; other site 402881004383 ATP binding site [chemical binding]; other site 402881004384 Walker B motif; other site 402881004385 inhibitor binding site; inhibition site 402881004386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 402881004387 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 402881004388 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 402881004389 gamma subunit interface [polypeptide binding]; other site 402881004390 epsilon subunit interface [polypeptide binding]; other site 402881004391 LBP interface [polypeptide binding]; other site 402881004392 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 402881004393 dinuclear metal binding motif [ion binding]; other site 402881004394 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 402881004395 dinuclear metal binding motif [ion binding]; other site 402881004396 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881004397 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 402881004398 putative active site [active] 402881004399 Ap4A binding site [chemical binding]; other site 402881004400 nudix motif; other site 402881004401 putative metal binding site [ion binding]; other site 402881004402 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 402881004403 NodB motif; other site 402881004404 putative active site [active] 402881004405 putative catalytic site [active] 402881004406 Zn binding site [ion binding]; other site 402881004407 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 402881004408 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 402881004409 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 402881004410 protein binding site [polypeptide binding]; other site 402881004411 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 402881004412 Catalytic dyad [active] 402881004413 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 402881004414 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881004415 phosphoglyceromutase; Provisional; Region: PRK05434 402881004416 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 402881004417 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 402881004418 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 402881004419 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 402881004420 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 402881004421 active site 402881004422 (T/H)XGH motif; other site 402881004423 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 402881004424 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 402881004425 putative catalytic cysteine [active] 402881004426 gamma-glutamyl kinase; Provisional; Region: PRK05429 402881004427 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 402881004428 nucleotide binding site [chemical binding]; other site 402881004429 homotetrameric interface [polypeptide binding]; other site 402881004430 putative phosphate binding site [ion binding]; other site 402881004431 putative allosteric binding site; other site 402881004432 PUA domain; Region: PUA; pfam01472 402881004433 GTPase CgtA; Reviewed; Region: obgE; PRK12299 402881004434 GTP1/OBG; Region: GTP1_OBG; pfam01018 402881004435 Obg GTPase; Region: Obg; cd01898 402881004436 G1 box; other site 402881004437 GTP/Mg2+ binding site [chemical binding]; other site 402881004438 Switch I region; other site 402881004439 G2 box; other site 402881004440 G3 box; other site 402881004441 Switch II region; other site 402881004442 G4 box; other site 402881004443 G5 box; other site 402881004444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 402881004445 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 402881004446 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 402881004447 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 402881004448 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 402881004449 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 402881004450 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 402881004451 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 402881004452 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 402881004453 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 402881004454 putative acyl-acceptor binding pocket; other site 402881004455 Phosphopantetheine attachment site; Region: PP-binding; cl09936 402881004456 Phosphopantetheine attachment site; Region: PP-binding; cl09936 402881004457 Predicted membrane protein [Function unknown]; Region: COG4648 402881004458 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 402881004459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881004460 AMP binding site [chemical binding]; other site 402881004461 active site 402881004462 acyl-activating enzyme (AAE) consensus motif; other site 402881004463 CoA binding site [chemical binding]; other site 402881004464 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 402881004465 active site 2 [active] 402881004466 active site 1 [active] 402881004467 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 402881004468 active sites [active] 402881004469 tetramer interface [polypeptide binding]; other site 402881004470 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881004471 active site 402881004472 Predicted exporter [General function prediction only]; Region: COG4258 402881004473 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 402881004474 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 402881004475 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 402881004476 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 402881004477 dimer interface [polypeptide binding]; other site 402881004478 active site 402881004479 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 402881004480 putative active site 1 [active] 402881004481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004482 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 402881004483 NAD(P) binding site [chemical binding]; other site 402881004484 active site 402881004485 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 402881004486 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 402881004487 dimer interface [polypeptide binding]; other site 402881004488 active site 402881004489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881004490 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881004491 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 402881004492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881004493 Walker A/P-loop; other site 402881004494 ATP binding site [chemical binding]; other site 402881004495 Q-loop/lid; other site 402881004496 ABC transporter signature motif; other site 402881004497 Walker B; other site 402881004498 D-loop; other site 402881004499 H-loop/switch region; other site 402881004500 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 402881004501 Walker A/P-loop; other site 402881004502 ATP binding site [chemical binding]; other site 402881004503 Q-loop/lid; other site 402881004504 ABC transporter signature motif; other site 402881004505 Walker B; other site 402881004506 D-loop; other site 402881004507 H-loop/switch region; other site 402881004508 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881004509 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 402881004510 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881004511 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 402881004512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004513 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 402881004514 NAD(P) binding site [chemical binding]; other site 402881004515 active site 402881004516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004518 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 402881004519 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 402881004520 heme binding site [chemical binding]; other site 402881004521 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 402881004522 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 402881004523 TIGR03032 family protein; Region: TIGR03032 402881004524 Autotransporter beta-domain; Region: Autotransporter; smart00869 402881004525 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 402881004526 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 402881004527 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 402881004528 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 402881004529 active site residues [active] 402881004530 dimer interface [polypeptide binding]; other site 402881004531 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 402881004532 Dodecin; Region: Dodecin; pfam07311 402881004533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881004534 classical (c) SDRs; Region: SDR_c; cd05233 402881004535 NAD(P) binding site [chemical binding]; other site 402881004536 active site 402881004537 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 402881004538 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 402881004539 methionine sulfoxide reductase B; Provisional; Region: PRK00222 402881004540 SelR domain; Region: SelR; pfam01641 402881004541 methionine sulfoxide reductase A; Provisional; Region: PRK14054 402881004542 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 402881004543 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 402881004544 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 402881004545 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 402881004546 metal-binding site [ion binding] 402881004547 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881004548 Soluble P-type ATPase [General function prediction only]; Region: COG4087 402881004549 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 402881004550 FixH; Region: FixH; pfam05751 402881004551 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 402881004552 4Fe-4S binding domain; Region: Fer4_5; pfam12801 402881004553 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 402881004554 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 402881004555 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 402881004556 Cytochrome c; Region: Cytochrom_C; pfam00034 402881004557 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 402881004558 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 402881004559 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 402881004560 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 402881004561 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 402881004562 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 402881004563 Low-spin heme binding site [chemical binding]; other site 402881004564 Putative water exit pathway; other site 402881004565 Binuclear center (active site) [active] 402881004566 Putative proton exit pathway; other site 402881004567 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 402881004568 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 402881004569 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881004570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881004571 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881004572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004574 WHG domain; Region: WHG; pfam13305 402881004575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004577 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 402881004578 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 402881004579 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 402881004580 putative active site [active] 402881004581 putative metal binding site [ion binding]; other site 402881004582 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 402881004583 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 402881004584 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 402881004585 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881004586 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881004587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881004588 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 402881004589 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881004590 Cytochrome P450; Region: p450; cl12078 402881004591 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 402881004592 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881004593 dimer interface [polypeptide binding]; other site 402881004594 active site 402881004595 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 402881004596 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 402881004597 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 402881004598 DNA binding residues [nucleotide binding] 402881004599 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 402881004600 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 402881004601 Walker A/P-loop; other site 402881004602 ATP binding site [chemical binding]; other site 402881004603 Q-loop/lid; other site 402881004604 ABC transporter signature motif; other site 402881004605 Walker B; other site 402881004606 D-loop; other site 402881004607 H-loop/switch region; other site 402881004608 TOBE domain; Region: TOBE_2; pfam08402 402881004609 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 402881004610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881004611 dimer interface [polypeptide binding]; other site 402881004612 conserved gate region; other site 402881004613 putative PBP binding loops; other site 402881004614 ABC-ATPase subunit interface; other site 402881004615 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 402881004616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881004617 dimer interface [polypeptide binding]; other site 402881004618 conserved gate region; other site 402881004619 putative PBP binding loops; other site 402881004620 ABC-ATPase subunit interface; other site 402881004621 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 402881004622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 402881004623 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 402881004624 active site 402881004625 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 402881004626 putative active site [active] 402881004627 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 402881004628 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 402881004629 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 402881004630 putative active site [active] 402881004631 putative CoA binding site [chemical binding]; other site 402881004632 nudix motif; other site 402881004633 metal binding site [ion binding]; metal-binding site 402881004634 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 402881004635 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 402881004636 hexamer interface [polypeptide binding]; other site 402881004637 ligand binding site [chemical binding]; other site 402881004638 putative active site [active] 402881004639 NAD(P) binding site [chemical binding]; other site 402881004640 Sporulation related domain; Region: SPOR; pfam05036 402881004641 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 402881004642 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 402881004643 putative active site [active] 402881004644 Zn binding site [ion binding]; other site 402881004645 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 402881004646 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 402881004647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881004648 catalytic residue [active] 402881004649 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 402881004650 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 402881004651 glutamine binding [chemical binding]; other site 402881004652 catalytic triad [active] 402881004653 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 402881004654 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 402881004655 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 402881004656 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881004657 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 402881004658 TAP-like protein; Region: Abhydrolase_4; pfam08386 402881004659 short chain dehydrogenase; Provisional; Region: PRK07576 402881004660 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 402881004661 NAD(P) binding site [chemical binding]; other site 402881004662 substrate binding site [chemical binding]; other site 402881004663 homotetramer interface [polypeptide binding]; other site 402881004664 active site 402881004665 homodimer interface [polypeptide binding]; other site 402881004666 enoyl-CoA hydratase; Provisional; Region: PRK09245 402881004667 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881004668 substrate binding site [chemical binding]; other site 402881004669 oxyanion hole (OAH) forming residues; other site 402881004670 trimer interface [polypeptide binding]; other site 402881004671 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 402881004672 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 402881004673 PAS fold; Region: PAS_3; pfam08447 402881004674 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 402881004675 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881004676 metal binding site [ion binding]; metal-binding site 402881004677 active site 402881004678 I-site; other site 402881004679 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 402881004680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 402881004681 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 402881004682 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 402881004683 putative acyltransferase; Provisional; Region: PRK05790 402881004684 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881004685 dimer interface [polypeptide binding]; other site 402881004686 active site 402881004687 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 402881004688 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 402881004689 NAD(P) binding site [chemical binding]; other site 402881004690 homotetramer interface [polypeptide binding]; other site 402881004691 homodimer interface [polypeptide binding]; other site 402881004692 active site 402881004693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 402881004694 Peptidase M15; Region: Peptidase_M15_3; cl01194 402881004695 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 402881004696 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 402881004697 NodB motif; other site 402881004698 active site 402881004699 catalytic site [active] 402881004700 metal binding site [ion binding]; metal-binding site 402881004701 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 402881004702 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 402881004703 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881004705 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 402881004706 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881004707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881004708 S-adenosylmethionine binding site [chemical binding]; other site 402881004709 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 402881004710 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 402881004711 hypothetical protein; Provisional; Region: PRK06034 402881004712 Chorismate mutase type II; Region: CM_2; cl00693 402881004713 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 402881004714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881004715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881004716 homodimer interface [polypeptide binding]; other site 402881004717 catalytic residue [active] 402881004718 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 402881004719 prephenate dehydrogenase; Validated; Region: PRK08507 402881004720 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 402881004721 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 402881004722 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 402881004723 putative active site pocket [active] 402881004724 dimerization interface [polypeptide binding]; other site 402881004725 putative catalytic residue [active] 402881004726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 402881004727 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 402881004728 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 402881004729 putative dimer interface [polypeptide binding]; other site 402881004730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881004731 ligand binding site [chemical binding]; other site 402881004732 Zn binding site [ion binding]; other site 402881004733 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 402881004734 putative lipid kinase; Reviewed; Region: PRK13057 402881004735 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 402881004736 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 402881004737 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 402881004738 active site 402881004739 dimer interface [polypeptide binding]; other site 402881004740 effector binding site; other site 402881004741 TSCPD domain; Region: TSCPD; pfam12637 402881004742 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 402881004743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 402881004744 putative acyl-acceptor binding pocket; other site 402881004745 Uncharacterized conserved protein [Function unknown]; Region: COG1434 402881004746 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 402881004747 putative active site [active] 402881004748 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 402881004749 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 402881004750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 402881004751 Walker A/P-loop; other site 402881004752 ATP binding site [chemical binding]; other site 402881004753 Q-loop/lid; other site 402881004754 ABC transporter signature motif; other site 402881004755 Walker B; other site 402881004756 D-loop; other site 402881004757 H-loop/switch region; other site 402881004758 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 402881004759 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 402881004760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881004761 active site 402881004762 Response regulator receiver domain; Region: Response_reg; pfam00072 402881004763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881004764 active site 402881004765 phosphorylation site [posttranslational modification] 402881004766 intermolecular recognition site; other site 402881004767 dimerization interface [polypeptide binding]; other site 402881004768 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 402881004769 diaminopimelate decarboxylase; Region: lysA; TIGR01048 402881004770 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 402881004771 active site 402881004772 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 402881004773 substrate binding site [chemical binding]; other site 402881004774 catalytic residues [active] 402881004775 dimer interface [polypeptide binding]; other site 402881004776 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 402881004777 argininosuccinate lyase; Provisional; Region: PRK00855 402881004778 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 402881004779 active sites [active] 402881004780 tetramer interface [polypeptide binding]; other site 402881004781 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 402881004782 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 402881004783 catalytic residues [active] 402881004784 Methyltransferase domain; Region: Methyltransf_31; pfam13847 402881004785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881004786 S-adenosylmethionine binding site [chemical binding]; other site 402881004787 PAS domain; Region: PAS_5; pfam07310 402881004788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881004789 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 402881004790 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 402881004791 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 402881004792 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 402881004793 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 402881004794 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 402881004795 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 402881004796 Ligand binding site [chemical binding]; other site 402881004797 Electron transfer flavoprotein domain; Region: ETF; pfam01012 402881004798 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 402881004799 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 402881004800 haloalkane dehalogenase; Provisional; Region: PRK03592 402881004801 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 402881004802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881004803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881004804 active site 402881004805 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 402881004806 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 402881004807 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 402881004808 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 402881004809 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 402881004810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881004811 dimerization interface [polypeptide binding]; other site 402881004812 putative DNA binding site [nucleotide binding]; other site 402881004813 putative Zn2+ binding site [ion binding]; other site 402881004814 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 402881004815 active site residue [active] 402881004816 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 402881004817 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 402881004818 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 402881004819 putative NAD(P) binding site [chemical binding]; other site 402881004820 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 402881004821 dinuclear metal binding motif [ion binding]; other site 402881004822 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881004823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881004824 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881004825 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881004826 active site 402881004827 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 402881004828 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 402881004829 B12 binding site [chemical binding]; other site 402881004830 cobalt ligand [ion binding]; other site 402881004831 Predicted permeases [General function prediction only]; Region: COG0679 402881004832 Predicted membrane protein [Function unknown]; Region: COG4763 402881004833 Acyltransferase family; Region: Acyl_transf_3; pfam01757 402881004834 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 402881004835 active site 402881004836 HIGH motif; other site 402881004837 nucleotide binding site [chemical binding]; other site 402881004838 active site 402881004839 KMSKS motif; other site 402881004840 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 402881004841 putative hydrolase; Provisional; Region: PRK11460 402881004842 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 402881004843 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 402881004844 active site 402881004845 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 402881004846 diiron binding motif [ion binding]; other site 402881004847 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 402881004848 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 402881004849 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 402881004850 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 402881004851 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 402881004852 Creatinine amidohydrolase; Region: Creatininase; pfam02633 402881004853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004857 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 402881004858 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 402881004859 ArsC family; Region: ArsC; pfam03960 402881004860 putative catalytic residues [active] 402881004861 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 402881004862 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 402881004863 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 402881004864 CPxP motif; other site 402881004865 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 402881004866 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 402881004867 acyl-activating enzyme (AAE) consensus motif; other site 402881004868 putative AMP binding site [chemical binding]; other site 402881004869 putative active site [active] 402881004870 putative CoA binding site [chemical binding]; other site 402881004871 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 402881004872 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 402881004873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881004874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881004875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004876 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881004877 NAD(P) binding site [chemical binding]; other site 402881004878 active site 402881004879 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 402881004880 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881004881 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881004882 C-terminal domain interface [polypeptide binding]; other site 402881004883 GSH binding site (G-site) [chemical binding]; other site 402881004884 dimer interface [polypeptide binding]; other site 402881004885 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881004886 N-terminal domain interface [polypeptide binding]; other site 402881004887 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881004888 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881004889 C-terminal domain interface [polypeptide binding]; other site 402881004890 GSH binding site (G-site) [chemical binding]; other site 402881004891 dimer interface [polypeptide binding]; other site 402881004892 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881004893 N-terminal domain interface [polypeptide binding]; other site 402881004894 dimer interface [polypeptide binding]; other site 402881004895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881004896 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 402881004897 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 402881004898 classical (c) SDRs; Region: SDR_c; cd05233 402881004899 NAD(P) binding site [chemical binding]; other site 402881004900 active site 402881004901 Uncharacterized conserved protein [Function unknown]; Region: COG2128 402881004902 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 402881004903 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 402881004904 Uncharacterized conserved protein [Function unknown]; Region: COG2128 402881004905 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 402881004906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881004907 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 402881004908 acyl-activating enzyme (AAE) consensus motif; other site 402881004909 putative AMP binding site [chemical binding]; other site 402881004910 putative active site [active] 402881004911 putative CoA binding site [chemical binding]; other site 402881004912 acyl-CoA synthetase; Provisional; Region: PRK12582 402881004913 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 402881004914 acyl-activating enzyme (AAE) consensus motif; other site 402881004915 putative AMP binding site [chemical binding]; other site 402881004916 putative active site [active] 402881004917 putative CoA binding site [chemical binding]; other site 402881004918 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 402881004919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004920 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 402881004921 NAD(P) binding site [chemical binding]; other site 402881004922 active site 402881004923 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 402881004924 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881004925 substrate binding pocket [chemical binding]; other site 402881004926 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881004927 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 402881004928 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 402881004929 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 402881004930 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 402881004931 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 402881004932 acyl-activating enzyme (AAE) consensus motif; other site 402881004933 putative AMP binding site [chemical binding]; other site 402881004934 putative active site [active] 402881004935 putative CoA binding site [chemical binding]; other site 402881004936 putative transporter; Provisional; Region: PRK11660 402881004937 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 402881004938 Sulfate transporter family; Region: Sulfate_transp; pfam00916 402881004939 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 402881004940 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 402881004941 FAD binding domain; Region: FAD_binding_4; pfam01565 402881004942 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 402881004943 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 402881004944 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 402881004945 hydroxyglutarate oxidase; Provisional; Region: PRK11728 402881004946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881004947 DNA binding residues [nucleotide binding] 402881004948 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 402881004949 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 402881004950 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 402881004951 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 402881004952 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 402881004953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881004954 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 402881004955 TAP-like protein; Region: Abhydrolase_4; pfam08386 402881004956 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 402881004957 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 402881004958 potential catalytic triad [active] 402881004959 conserved cys residue [active] 402881004960 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881004961 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 402881004962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881004963 NAD(P) binding site [chemical binding]; other site 402881004964 active site 402881004965 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 402881004966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881004967 active site 402881004968 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 402881004969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881004970 Walker A/P-loop; other site 402881004971 ATP binding site [chemical binding]; other site 402881004972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881004973 Walker B; other site 402881004974 D-loop; other site 402881004975 H-loop/switch region; other site 402881004976 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 402881004977 putative active site [active] 402881004978 putative metal-binding site [ion binding]; other site 402881004979 PAS domain; Region: PAS_5; pfam07310 402881004980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881004981 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881004982 CoenzymeA binding site [chemical binding]; other site 402881004983 subunit interaction site [polypeptide binding]; other site 402881004984 PHB binding site; other site 402881004985 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 402881004986 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881004987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881004988 substrate binding site [chemical binding]; other site 402881004989 oxyanion hole (OAH) forming residues; other site 402881004990 trimer interface [polypeptide binding]; other site 402881004991 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 402881004992 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 402881004993 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 402881004994 putative active site [active] 402881004995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881004996 non-specific DNA binding site [nucleotide binding]; other site 402881004997 salt bridge; other site 402881004998 sequence-specific DNA binding site [nucleotide binding]; other site 402881004999 Predicted transcriptional regulator [Transcription]; Region: COG2932 402881005000 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 402881005001 Catalytic site [active] 402881005002 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881005003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881005004 DNA binding residues [nucleotide binding] 402881005005 dimerization interface [polypeptide binding]; other site 402881005006 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 402881005007 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 402881005008 Catalytic site; other site 402881005009 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 402881005010 Peptidase family M48; Region: Peptidase_M48; pfam01435 402881005011 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 402881005012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881005013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881005014 DNA binding residues [nucleotide binding] 402881005015 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 402881005016 Ferredoxin [Energy production and conversion]; Region: COG1146 402881005017 4Fe-4S binding domain; Region: Fer4; cl02805 402881005018 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 402881005019 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 402881005020 putative metal binding site [ion binding]; other site 402881005021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 402881005022 RNA binding surface [nucleotide binding]; other site 402881005023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 402881005024 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 402881005025 ATP binding site [chemical binding]; other site 402881005026 putative Mg++ binding site [ion binding]; other site 402881005027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881005028 nucleotide binding region [chemical binding]; other site 402881005029 ATP-binding site [chemical binding]; other site 402881005030 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881005031 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 402881005032 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 402881005033 active site 402881005034 PAS domain S-box; Region: sensory_box; TIGR00229 402881005035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881005036 putative active site [active] 402881005037 heme pocket [chemical binding]; other site 402881005038 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 402881005039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881005040 dimer interface [polypeptide binding]; other site 402881005041 phosphorylation site [posttranslational modification] 402881005042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881005043 ATP binding site [chemical binding]; other site 402881005044 Mg2+ binding site [ion binding]; other site 402881005045 G-X-G motif; other site 402881005046 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881005047 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 402881005048 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 402881005049 active site 402881005050 substrate binding site [chemical binding]; other site 402881005051 coenzyme B12 binding site [chemical binding]; other site 402881005052 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 402881005053 B12 binding site [chemical binding]; other site 402881005054 cobalt ligand [ion binding]; other site 402881005055 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 402881005056 membrane ATPase/protein kinase; Provisional; Region: PRK09435 402881005057 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 402881005058 Walker A; other site 402881005059 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 402881005060 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 402881005061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 402881005062 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 402881005063 multidrug efflux protein; Reviewed; Region: PRK01766 402881005064 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 402881005065 cation binding site [ion binding]; other site 402881005066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881005067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881005069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005070 Predicted transcriptional regulator [Transcription]; Region: COG2345 402881005071 Transcriptional regulator PadR-like family; Region: PadR; cl17335 402881005072 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 402881005073 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 402881005074 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 402881005075 metal ion-dependent adhesion site (MIDAS); other site 402881005076 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 402881005077 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 402881005078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 402881005079 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 402881005080 HSP70 interaction site [polypeptide binding]; other site 402881005081 BolA-like protein; Region: BolA; pfam01722 402881005082 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 402881005083 Domain of unknown function DUF21; Region: DUF21; pfam01595 402881005084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 402881005085 Transporter associated domain; Region: CorC_HlyC; smart01091 402881005086 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 402881005087 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 402881005088 active site 402881005089 dimer interface [polypeptide binding]; other site 402881005090 metal binding site [ion binding]; metal-binding site 402881005091 shikimate kinase; Provisional; Region: PRK13946 402881005092 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 402881005093 ADP binding site [chemical binding]; other site 402881005094 magnesium binding site [ion binding]; other site 402881005095 putative shikimate binding site; other site 402881005096 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 402881005097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 402881005098 active site 402881005099 DNA binding site [nucleotide binding] 402881005100 Int/Topo IB signature motif; other site 402881005101 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 402881005102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881005103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881005104 DNA binding residues [nucleotide binding] 402881005105 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 402881005106 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 402881005107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881005108 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 402881005109 transmembrane helices; other site 402881005110 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 402881005111 TrkA-C domain; Region: TrkA_C; pfam02080 402881005112 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 402881005113 Epoxide hydrolase N terminus; Region: EHN; pfam06441 402881005114 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881005115 Epoxide hydrolase N terminus; Region: EHN; pfam06441 402881005116 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881005117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881005118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005119 putative substrate translocation pore; other site 402881005120 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 402881005121 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 402881005122 SEC-C motif; Region: SEC-C; pfam02810 402881005123 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 402881005124 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 402881005125 heterotetramer interface [polypeptide binding]; other site 402881005126 active site pocket [active] 402881005127 cleavage site 402881005128 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 402881005129 active site 402881005130 8-oxo-dGMP binding site [chemical binding]; other site 402881005131 nudix motif; other site 402881005132 metal binding site [ion binding]; metal-binding site 402881005133 Flp/Fap pilin component; Region: Flp_Fap; cl01585 402881005134 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 402881005135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881005136 S-adenosylmethionine binding site [chemical binding]; other site 402881005137 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 402881005138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881005139 active site 402881005140 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 402881005141 GSH binding site [chemical binding]; other site 402881005142 catalytic residues [active] 402881005143 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 402881005144 nitrilase; Region: PLN02798 402881005145 putative active site [active] 402881005146 catalytic triad [active] 402881005147 dimer interface [polypeptide binding]; other site 402881005148 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 402881005149 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 402881005150 FAD binding domain; Region: FAD_binding_4; pfam01565 402881005151 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 402881005152 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 402881005153 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 402881005154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881005155 S-adenosylmethionine binding site [chemical binding]; other site 402881005156 aspartate kinase; Reviewed; Region: PRK06635 402881005157 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 402881005158 putative nucleotide binding site [chemical binding]; other site 402881005159 putative catalytic residues [active] 402881005160 putative Mg ion binding site [ion binding]; other site 402881005161 putative aspartate binding site [chemical binding]; other site 402881005162 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 402881005163 putative allosteric regulatory site; other site 402881005164 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 402881005165 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 402881005166 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 402881005167 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 402881005168 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 402881005169 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 402881005170 Helix-turn-helix domain; Region: HTH_25; pfam13413 402881005171 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 402881005172 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 402881005173 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 402881005174 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 402881005175 peptide chain release factor 1; Validated; Region: prfA; PRK00591 402881005176 This domain is found in peptide chain release factors; Region: PCRF; smart00937 402881005177 RF-1 domain; Region: RF-1; pfam00472 402881005178 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 402881005179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881005180 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 402881005181 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 402881005182 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 402881005183 MOSC domain; Region: MOSC; pfam03473 402881005184 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 402881005185 Clp amino terminal domain; Region: Clp_N; pfam02861 402881005186 Clp amino terminal domain; Region: Clp_N; pfam02861 402881005187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881005188 Walker A motif; other site 402881005189 ATP binding site [chemical binding]; other site 402881005190 Walker B motif; other site 402881005191 arginine finger; other site 402881005192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881005193 Walker A motif; other site 402881005194 ATP binding site [chemical binding]; other site 402881005195 Walker B motif; other site 402881005196 arginine finger; other site 402881005197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 402881005198 short chain dehydrogenase; Provisional; Region: PRK07478 402881005199 classical (c) SDRs; Region: SDR_c; cd05233 402881005200 NAD(P) binding site [chemical binding]; other site 402881005201 active site 402881005202 putative peptidase; Provisional; Region: PRK11649 402881005203 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881005204 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 402881005205 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 402881005206 catalytic residues [active] 402881005207 catalytic nucleophile [active] 402881005208 Recombinase; Region: Recombinase; pfam07508 402881005209 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 402881005210 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 402881005211 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 402881005212 active site 402881005213 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 402881005214 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 402881005215 DUF35 OB-fold domain; Region: DUF35; pfam01796 402881005216 acyl-CoA synthetase; Validated; Region: PRK07798 402881005217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881005218 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 402881005219 acyl-activating enzyme (AAE) consensus motif; other site 402881005220 acyl-activating enzyme (AAE) consensus motif; other site 402881005221 putative AMP binding site [chemical binding]; other site 402881005222 putative active site [active] 402881005223 putative CoA binding site [chemical binding]; other site 402881005224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881005225 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 402881005226 NAD(P) binding site [chemical binding]; other site 402881005227 active site 402881005228 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 402881005229 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 402881005230 iron-sulfur cluster [ion binding]; other site 402881005231 [2Fe-2S] cluster binding site [ion binding]; other site 402881005232 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 402881005233 putative alpha subunit interface [polypeptide binding]; other site 402881005234 putative active site [active] 402881005235 putative substrate binding site [chemical binding]; other site 402881005236 Fe binding site [ion binding]; other site 402881005237 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 402881005238 inter-subunit interface; other site 402881005239 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 402881005240 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 402881005241 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 402881005242 active site 2 [active] 402881005243 active site 1 [active] 402881005244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881005245 Cytochrome P450; Region: p450; cl12078 402881005246 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 402881005247 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 402881005248 acyl-activating enzyme (AAE) consensus motif; other site 402881005249 putative AMP binding site [chemical binding]; other site 402881005250 putative active site [active] 402881005251 putative CoA binding site [chemical binding]; other site 402881005252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881005253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881005254 NAD(P) binding site [chemical binding]; other site 402881005255 active site 402881005256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881005257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881005258 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 402881005259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881005260 NAD(P) binding site [chemical binding]; other site 402881005261 active site 402881005262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881005263 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 402881005264 substrate binding site [chemical binding]; other site 402881005265 oxyanion hole (OAH) forming residues; other site 402881005266 trimer interface [polypeptide binding]; other site 402881005267 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881005268 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 402881005269 active site 402881005270 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881005271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881005272 substrate binding site [chemical binding]; other site 402881005273 oxyanion hole (OAH) forming residues; other site 402881005274 trimer interface [polypeptide binding]; other site 402881005275 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 402881005276 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 402881005277 [2Fe-2S] cluster binding site [ion binding]; other site 402881005278 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 402881005279 putative alpha subunit interface [polypeptide binding]; other site 402881005280 putative active site [active] 402881005281 putative substrate binding site [chemical binding]; other site 402881005282 Fe binding site [ion binding]; other site 402881005283 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 402881005284 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 402881005285 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881005286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881005287 substrate binding site [chemical binding]; other site 402881005288 oxyanion hole (OAH) forming residues; other site 402881005289 trimer interface [polypeptide binding]; other site 402881005290 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881005291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881005292 Transcriptional regulators [Transcription]; Region: FadR; COG2186 402881005293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 402881005294 DNA-binding site [nucleotide binding]; DNA binding site 402881005295 FCD domain; Region: FCD; pfam07729 402881005296 Nitronate monooxygenase; Region: NMO; pfam03060 402881005297 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881005298 FMN binding site [chemical binding]; other site 402881005299 substrate binding site [chemical binding]; other site 402881005300 putative catalytic residue [active] 402881005301 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881005302 CoenzymeA binding site [chemical binding]; other site 402881005303 subunit interaction site [polypeptide binding]; other site 402881005304 PHB binding site; other site 402881005305 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 402881005306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881005307 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881005308 Cytochrome P450; Region: p450; cl12078 402881005309 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 402881005310 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881005311 catalytic loop [active] 402881005312 iron binding site [ion binding]; other site 402881005313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881005314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881005315 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 402881005316 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 402881005317 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881005318 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 402881005319 NAD binding site [chemical binding]; other site 402881005320 catalytic residues [active] 402881005321 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 402881005322 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 402881005323 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 402881005324 active site 402881005325 Fe binding site [ion binding]; other site 402881005326 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 402881005327 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 402881005328 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 402881005329 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 402881005330 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 402881005331 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 402881005332 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 402881005333 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 402881005334 enoyl-CoA hydratase; Provisional; Region: PRK07799 402881005335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881005336 substrate binding site [chemical binding]; other site 402881005337 oxyanion hole (OAH) forming residues; other site 402881005338 trimer interface [polypeptide binding]; other site 402881005339 Amidohydrolase; Region: Amidohydro_2; pfam04909 402881005340 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 402881005341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881005342 active site 402881005343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881005344 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881005345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881005346 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 402881005347 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 402881005348 Bacterial transcriptional regulator; Region: IclR; pfam01614 402881005349 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 402881005350 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 402881005351 active site 402881005352 FMN binding site [chemical binding]; other site 402881005353 2,4-decadienoyl-CoA binding site; other site 402881005354 catalytic residue [active] 402881005355 4Fe-4S cluster binding site [ion binding]; other site 402881005356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 402881005357 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 402881005358 enoyl-CoA hydratase; Region: PLN02864 402881005359 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 402881005360 dimer interaction site [polypeptide binding]; other site 402881005361 substrate-binding tunnel; other site 402881005362 active site 402881005363 catalytic site [active] 402881005364 substrate binding site [chemical binding]; other site 402881005365 Uncharacterized conserved protein [Function unknown]; Region: COG2128 402881005366 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 402881005367 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 402881005368 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 402881005369 NAD(P) binding site [chemical binding]; other site 402881005370 lipid-transfer protein; Provisional; Region: PRK07855 402881005371 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 402881005372 active site 402881005373 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 402881005374 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 402881005375 DUF35 OB-fold domain; Region: DUF35; pfam01796 402881005376 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881005377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881005378 active site 402881005379 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881005380 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 402881005381 active site 402881005382 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881005383 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 402881005384 FAD binding site [chemical binding]; other site 402881005385 substrate binding site [chemical binding]; other site 402881005386 catalytic base [active] 402881005387 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 402881005388 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 402881005389 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 402881005390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881005391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881005392 non-specific DNA binding site [nucleotide binding]; other site 402881005393 salt bridge; other site 402881005394 sequence-specific DNA binding site [nucleotide binding]; other site 402881005395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 402881005396 sequence-specific DNA binding site [nucleotide binding]; other site 402881005397 salt bridge; other site 402881005398 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 402881005399 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 402881005400 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 402881005401 ParB-like nuclease domain; Region: ParB; smart00470 402881005402 Protein of unknown function (DUF736); Region: DUF736; pfam05284 402881005403 Helix-turn-helix domain; Region: HTH_17; pfam12728 402881005404 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 402881005405 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 402881005406 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 402881005407 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 402881005408 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881005409 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881005410 catalytic residue [active] 402881005411 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 402881005412 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 402881005413 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 402881005414 active site 402881005415 catalytic site [active] 402881005416 substrate binding site [chemical binding]; other site 402881005417 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 402881005418 Domain of unknown function (DUF955); Region: DUF955; pfam06114 402881005419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881005420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881005421 non-specific DNA binding site [nucleotide binding]; other site 402881005422 salt bridge; other site 402881005423 sequence-specific DNA binding site [nucleotide binding]; other site 402881005424 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 402881005425 AAA domain; Region: AAA_25; pfam13481 402881005426 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 402881005427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881005428 Walker A motif; other site 402881005429 ATP binding site [chemical binding]; other site 402881005430 Walker B motif; other site 402881005431 arginine finger; other site 402881005432 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 402881005433 active site 402881005434 NTP binding site [chemical binding]; other site 402881005435 metal binding triad [ion binding]; metal-binding site 402881005436 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 402881005437 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 402881005438 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 402881005439 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 402881005440 Walker A motif; other site 402881005441 ATP binding site [chemical binding]; other site 402881005442 Walker B motif; other site 402881005443 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 402881005444 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 402881005445 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 402881005446 ATP binding site [chemical binding]; other site 402881005447 Walker A motif; other site 402881005448 hexamer interface [polypeptide binding]; other site 402881005449 Walker B motif; other site 402881005450 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 402881005451 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 402881005452 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 402881005453 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 402881005454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881005455 Walker B; other site 402881005456 D-loop; other site 402881005457 H-loop/switch region; other site 402881005458 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 402881005459 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 402881005460 conjugal transfer protein TrbL; Provisional; Region: PRK13875 402881005461 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 402881005462 conjugal transfer protein TrbF; Provisional; Region: PRK13872 402881005463 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 402881005464 VirB7 interaction site; other site 402881005465 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 402881005466 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 402881005467 Uncharacterized conserved protein [Function unknown]; Region: COG5489 402881005468 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 402881005469 NACHT domain; Region: NACHT; pfam05729 402881005470 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 402881005471 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 402881005472 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 402881005473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881005474 dimer interface [polypeptide binding]; other site 402881005475 phosphorylation site [posttranslational modification] 402881005476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881005477 ATP binding site [chemical binding]; other site 402881005478 Mg2+ binding site [ion binding]; other site 402881005479 G-X-G motif; other site 402881005480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881005481 active site 402881005482 phosphorylation site [posttranslational modification] 402881005483 intermolecular recognition site; other site 402881005484 dimerization interface [polypeptide binding]; other site 402881005485 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 402881005486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881005487 active site 402881005488 phosphorylation site [posttranslational modification] 402881005489 intermolecular recognition site; other site 402881005490 dimerization interface [polypeptide binding]; other site 402881005491 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 402881005492 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 402881005493 intersubunit interface [polypeptide binding]; other site 402881005494 active site 402881005495 Zn2+ binding site [ion binding]; other site 402881005496 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 402881005497 Cupin domain; Region: Cupin_2; cl17218 402881005498 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 402881005499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 402881005500 motif II; other site 402881005501 Transglycosylase; Region: Transgly; cl17702 402881005502 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 402881005503 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 402881005504 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 402881005505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881005506 NAD binding site [chemical binding]; other site 402881005507 catalytic residues [active] 402881005508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881005511 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 402881005512 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 402881005513 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 402881005514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881005515 N-terminal plug; other site 402881005516 ligand-binding site [chemical binding]; other site 402881005517 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 402881005518 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 402881005519 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 402881005520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881005521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881005522 DNA binding residues [nucleotide binding] 402881005523 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 402881005524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 402881005525 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 402881005526 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 402881005527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881005528 metal binding site [ion binding]; metal-binding site 402881005529 active site 402881005530 I-site; other site 402881005531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 402881005532 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881005533 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881005534 active site 402881005535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881005536 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 402881005537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881005538 active site 402881005539 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 402881005540 Uncharacterized conserved protein [Function unknown]; Region: COG4095 402881005541 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 402881005542 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 402881005543 putative NAD(P) binding site [chemical binding]; other site 402881005544 catalytic Zn binding site [ion binding]; other site 402881005545 putative glutathione S-transferase; Provisional; Region: PRK10357 402881005546 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 402881005547 putative C-terminal domain interface [polypeptide binding]; other site 402881005548 putative GSH binding site (G-site) [chemical binding]; other site 402881005549 putative dimer interface [polypeptide binding]; other site 402881005550 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 402881005551 dimer interface [polypeptide binding]; other site 402881005552 N-terminal domain interface [polypeptide binding]; other site 402881005553 putative substrate binding pocket (H-site) [chemical binding]; other site 402881005554 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 402881005555 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 402881005556 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 402881005557 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 402881005558 putative active site [active] 402881005559 catalytic site [active] 402881005560 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 402881005561 putative active site [active] 402881005562 catalytic site [active] 402881005563 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 402881005564 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881005565 N-terminal plug; other site 402881005566 ligand-binding site [chemical binding]; other site 402881005567 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 402881005568 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 402881005569 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 402881005570 active site 402881005571 catalytic residues [active] 402881005572 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 402881005573 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 402881005574 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 402881005575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881005576 dimer interface [polypeptide binding]; other site 402881005577 conserved gate region; other site 402881005578 putative PBP binding loops; other site 402881005579 ABC-ATPase subunit interface; other site 402881005580 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 402881005581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 402881005582 Walker A/P-loop; other site 402881005583 ATP binding site [chemical binding]; other site 402881005584 Q-loop/lid; other site 402881005585 ABC transporter signature motif; other site 402881005586 Walker B; other site 402881005587 D-loop; other site 402881005588 H-loop/switch region; other site 402881005589 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 402881005590 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 402881005591 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 402881005592 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 402881005593 urea carboxylase; Region: urea_carbox; TIGR02712 402881005594 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881005595 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881005596 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 402881005597 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 402881005598 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 402881005599 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881005600 carboxyltransferase (CT) interaction site; other site 402881005601 biotinylation site [posttranslational modification]; other site 402881005602 allophanate hydrolase; Provisional; Region: PRK08186 402881005603 Amidase; Region: Amidase; cl11426 402881005604 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 402881005605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881005606 active site 402881005607 motif I; other site 402881005608 motif II; other site 402881005609 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 402881005610 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 402881005611 putative ribose interaction site [chemical binding]; other site 402881005612 putative ADP binding site [chemical binding]; other site 402881005613 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 402881005614 active site 402881005615 nucleotide binding site [chemical binding]; other site 402881005616 HIGH motif; other site 402881005617 KMSKS motif; other site 402881005618 CAAX protease self-immunity; Region: Abi; pfam02517 402881005619 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 402881005620 dimer interface [polypeptide binding]; other site 402881005621 active site 402881005622 Tetratricopeptide repeat; Region: TPR_9; pfam13371 402881005623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881005624 TPR motif; other site 402881005625 binding surface 402881005626 Protein of unknown function (DUF560); Region: DUF560; pfam04575 402881005627 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 402881005628 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 402881005629 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 402881005630 putative active site [active] 402881005631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 402881005632 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 402881005633 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 402881005634 active site 402881005635 metal binding site [ion binding]; metal-binding site 402881005636 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 402881005637 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 402881005638 SLBB domain; Region: SLBB; pfam10531 402881005639 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 402881005640 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 402881005641 Chain length determinant protein; Region: Wzz; cl15801 402881005642 AAA domain; Region: AAA_31; pfam13614 402881005643 O-Antigen ligase; Region: Wzy_C; pfam04932 402881005644 Acyltransferase family; Region: Acyl_transf_3; pfam01757 402881005645 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 402881005646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881005647 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 402881005648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881005649 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 402881005650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881005651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 402881005652 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 402881005653 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 402881005654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881005655 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 402881005656 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 402881005657 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 402881005658 active site 402881005659 O-Antigen ligase; Region: Wzy_C; pfam04932 402881005660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881005661 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 402881005662 putative ADP-binding pocket [chemical binding]; other site 402881005663 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881005664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881005665 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 402881005666 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 402881005667 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 402881005668 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 402881005669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 402881005670 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 402881005671 putative NAD(P) binding site [chemical binding]; other site 402881005672 active site 402881005673 putative substrate binding site [chemical binding]; other site 402881005674 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 402881005675 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 402881005676 NADP-binding site; other site 402881005677 homotetramer interface [polypeptide binding]; other site 402881005678 substrate binding site [chemical binding]; other site 402881005679 homodimer interface [polypeptide binding]; other site 402881005680 active site 402881005681 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 402881005682 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 402881005683 NADP-binding site; other site 402881005684 homotetramer interface [polypeptide binding]; other site 402881005685 substrate binding site [chemical binding]; other site 402881005686 homodimer interface [polypeptide binding]; other site 402881005687 active site 402881005688 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 402881005689 Bacterial sugar transferase; Region: Bac_transf; pfam02397 402881005690 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 402881005691 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 402881005692 active site 402881005693 tetramer interface; other site 402881005694 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 402881005695 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 402881005696 Substrate binding site; other site 402881005697 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 402881005698 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 402881005699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881005700 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 402881005701 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 402881005702 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 402881005703 Bacterial sugar transferase; Region: Bac_transf; pfam02397 402881005704 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 402881005705 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 402881005706 nucleotide binding site/active site [active] 402881005707 HIT family signature motif; other site 402881005708 catalytic residue [active] 402881005709 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 402881005710 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 402881005711 galactokinase; Provisional; Region: PRK00555 402881005712 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 402881005713 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 402881005714 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 402881005715 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 402881005716 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 402881005717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881005718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881005719 dimer interface [polypeptide binding]; other site 402881005720 phosphorylation site [posttranslational modification] 402881005721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881005722 ATP binding site [chemical binding]; other site 402881005723 Mg2+ binding site [ion binding]; other site 402881005724 G-X-G motif; other site 402881005725 Domain of unknown function (DUF368); Region: DUF368; pfam04018 402881005726 alpha-galactosidase; Provisional; Region: PRK15076 402881005727 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 402881005728 NAD binding site [chemical binding]; other site 402881005729 sugar binding site [chemical binding]; other site 402881005730 divalent metal binding site [ion binding]; other site 402881005731 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 402881005732 dimer interface [polypeptide binding]; other site 402881005733 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 402881005734 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 402881005735 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 402881005736 Transglycosylase SLT domain; Region: SLT_2; pfam13406 402881005737 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881005738 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881005739 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 402881005740 Uncharacterized conserved protein [Function unknown]; Region: COG2308 402881005741 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 402881005742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 402881005743 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 402881005744 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 402881005745 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 402881005746 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 402881005747 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 402881005748 active site 402881005749 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 402881005750 Acyltransferase family; Region: Acyl_transf_3; pfam01757 402881005751 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 402881005752 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881005753 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 402881005754 putative N-terminal domain interface [polypeptide binding]; other site 402881005755 putative dimer interface [polypeptide binding]; other site 402881005756 putative substrate binding pocket (H-site) [chemical binding]; other site 402881005757 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881005758 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 402881005759 substrate binding site [chemical binding]; other site 402881005760 oxyanion hole (OAH) forming residues; other site 402881005761 trimer interface [polypeptide binding]; other site 402881005762 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 402881005763 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 402881005764 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 402881005765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881005766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881005767 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881005768 Cytochrome P450; Region: p450; cl12078 402881005769 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 402881005770 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 402881005771 [2Fe-2S] cluster binding site [ion binding]; other site 402881005772 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 402881005773 putative alpha subunit interface [polypeptide binding]; other site 402881005774 putative active site [active] 402881005775 putative substrate binding site [chemical binding]; other site 402881005776 Fe binding site [ion binding]; other site 402881005777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881005778 non-specific DNA binding site [nucleotide binding]; other site 402881005779 salt bridge; other site 402881005780 sequence-specific DNA binding site [nucleotide binding]; other site 402881005781 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 402881005782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881005783 Walker A motif; other site 402881005784 ATP binding site [chemical binding]; other site 402881005785 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 402881005786 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 402881005787 active site 402881005788 catalytic triad [active] 402881005789 oxyanion hole [active] 402881005790 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 402881005791 active site 402881005792 oxyanion hole [active] 402881005793 catalytic triad [active] 402881005794 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 402881005795 Predicted membrane protein [Function unknown]; Region: COG4392 402881005796 AzlC protein; Region: AzlC; pfam03591 402881005797 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 402881005798 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 402881005799 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 402881005800 active site 402881005801 dimer interface [polypeptide binding]; other site 402881005802 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 402881005803 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 402881005804 active site 402881005805 FMN binding site [chemical binding]; other site 402881005806 substrate binding site [chemical binding]; other site 402881005807 3Fe-4S cluster binding site [ion binding]; other site 402881005808 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 402881005809 domain interface; other site 402881005810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 402881005811 active site 402881005812 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 402881005813 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 402881005814 tetramer interface [polypeptide binding]; other site 402881005815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881005816 catalytic residue [active] 402881005817 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 402881005818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881005819 putative active site [active] 402881005820 heme pocket [chemical binding]; other site 402881005821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881005822 dimer interface [polypeptide binding]; other site 402881005823 phosphorylation site [posttranslational modification] 402881005824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881005825 ATP binding site [chemical binding]; other site 402881005826 Mg2+ binding site [ion binding]; other site 402881005827 G-X-G motif; other site 402881005828 Response regulator receiver domain; Region: Response_reg; pfam00072 402881005829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881005830 active site 402881005831 phosphorylation site [posttranslational modification] 402881005832 intermolecular recognition site; other site 402881005833 dimerization interface [polypeptide binding]; other site 402881005834 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 402881005835 CoA binding domain; Region: CoA_binding_2; pfam13380 402881005836 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 402881005837 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 402881005838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 402881005839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881005840 Coenzyme A binding pocket [chemical binding]; other site 402881005841 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 402881005842 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 402881005843 putative dimer interface [polypeptide binding]; other site 402881005844 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 402881005845 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 402881005846 putative ligand binding site [chemical binding]; other site 402881005847 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 402881005848 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 402881005849 TM-ABC transporter signature motif; other site 402881005850 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 402881005851 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 402881005852 TM-ABC transporter signature motif; other site 402881005853 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 402881005854 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 402881005855 Walker A/P-loop; other site 402881005856 ATP binding site [chemical binding]; other site 402881005857 Q-loop/lid; other site 402881005858 ABC transporter signature motif; other site 402881005859 Walker B; other site 402881005860 D-loop; other site 402881005861 H-loop/switch region; other site 402881005862 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 402881005863 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 402881005864 Walker A/P-loop; other site 402881005865 ATP binding site [chemical binding]; other site 402881005866 Q-loop/lid; other site 402881005867 ABC transporter signature motif; other site 402881005868 Walker B; other site 402881005869 D-loop; other site 402881005870 H-loop/switch region; other site 402881005871 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 402881005872 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 402881005873 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 402881005874 SCP-2 sterol transfer family; Region: SCP2; pfam02036 402881005875 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 402881005876 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881005877 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 402881005878 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 402881005879 active site 402881005880 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 402881005881 Amidohydrolase; Region: Amidohydro_2; pfam04909 402881005882 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 402881005883 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 402881005884 G1 box; other site 402881005885 putative GEF interaction site [polypeptide binding]; other site 402881005886 GTP/Mg2+ binding site [chemical binding]; other site 402881005887 Switch I region; other site 402881005888 G2 box; other site 402881005889 G3 box; other site 402881005890 Switch II region; other site 402881005891 G4 box; other site 402881005892 G5 box; other site 402881005893 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 402881005894 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 402881005895 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 402881005896 putative hydrophobic ligand binding site [chemical binding]; other site 402881005897 protein interface [polypeptide binding]; other site 402881005898 gate; other site 402881005899 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 402881005900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881005901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881005902 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 402881005903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881005904 Uncharacterized conserved protein [Function unknown]; Region: COG2353 402881005905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881005906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005907 putative substrate translocation pore; other site 402881005908 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 402881005909 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 402881005910 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 402881005911 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 402881005912 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 402881005913 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 402881005914 putative active site [active] 402881005915 putative metal binding site [ion binding]; other site 402881005916 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 402881005917 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 402881005918 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 402881005919 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 402881005920 active site 402881005921 FMN binding site [chemical binding]; other site 402881005922 substrate binding site [chemical binding]; other site 402881005923 3Fe-4S cluster binding site [ion binding]; other site 402881005924 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 402881005925 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881005926 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881005927 N-formylglutamate amidohydrolase; Region: FGase; cl01522 402881005928 Response regulator receiver domain; Region: Response_reg; pfam00072 402881005929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881005930 active site 402881005931 phosphorylation site [posttranslational modification] 402881005932 intermolecular recognition site; other site 402881005933 dimerization interface [polypeptide binding]; other site 402881005934 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881005935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881005936 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881005937 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 402881005938 Protein export membrane protein; Region: SecD_SecF; cl14618 402881005939 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 402881005940 Radical SAM superfamily; Region: Radical_SAM; pfam04055 402881005941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881005942 FeS/SAM binding site; other site 402881005943 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 402881005944 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 402881005945 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881005946 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881005947 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 402881005948 putative C-terminal domain interface [polypeptide binding]; other site 402881005949 putative GSH binding site (G-site) [chemical binding]; other site 402881005950 putative dimer interface [polypeptide binding]; other site 402881005951 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881005952 N-terminal domain interface [polypeptide binding]; other site 402881005953 dimer interface [polypeptide binding]; other site 402881005954 substrate binding pocket (H-site) [chemical binding]; other site 402881005955 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 402881005956 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 402881005957 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 402881005958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881005959 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 402881005960 active site 402881005961 thiolase; Provisional; Region: PRK06158 402881005962 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 402881005963 active site 402881005964 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 402881005965 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 402881005966 DUF35 OB-fold domain; Region: DUF35; pfam01796 402881005967 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 402881005968 putative FMN binding site [chemical binding]; other site 402881005969 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 402881005970 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881005971 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 402881005972 N-terminal domain interface [polypeptide binding]; other site 402881005973 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881005974 Sulfatase; Region: Sulfatase; pfam00884 402881005975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881005976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881005977 DNA binding residues [nucleotide binding] 402881005978 dimerization interface [polypeptide binding]; other site 402881005979 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 402881005980 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 402881005981 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881005982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881005983 active site 402881005984 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881005985 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881005986 C-terminal domain interface [polypeptide binding]; other site 402881005987 GSH binding site (G-site) [chemical binding]; other site 402881005988 dimer interface [polypeptide binding]; other site 402881005989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881005990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881005991 putative substrate translocation pore; other site 402881005992 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881005993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 402881005994 active site 402881005995 phosphorylation site [posttranslational modification] 402881005996 intermolecular recognition site; other site 402881005997 CHASE3 domain; Region: CHASE3; pfam05227 402881005998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 402881005999 Histidine kinase; Region: HisKA_2; pfam07568 402881006000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881006001 ATP binding site [chemical binding]; other site 402881006002 Mg2+ binding site [ion binding]; other site 402881006003 G-X-G motif; other site 402881006004 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 402881006005 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 402881006006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881006007 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 402881006008 Uncharacterized conserved protein [Function unknown]; Region: COG3268 402881006009 TPR repeat; Region: TPR_11; pfam13414 402881006010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881006011 binding surface 402881006012 TPR motif; other site 402881006013 TPR repeat; Region: TPR_11; pfam13414 402881006014 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881006015 pyruvate kinase; Provisional; Region: PRK06247 402881006016 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 402881006017 domain interfaces; other site 402881006018 active site 402881006019 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 402881006020 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 402881006021 MOFRL family; Region: MOFRL; pfam05161 402881006022 N-formylglutamate amidohydrolase; Region: FGase; cl01522 402881006023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 402881006024 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 402881006025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881006026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881006027 DNA binding residues [nucleotide binding] 402881006028 dimerization interface [polypeptide binding]; other site 402881006029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881006030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881006031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881006032 DNA binding residues [nucleotide binding] 402881006033 dimerization interface [polypeptide binding]; other site 402881006034 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 402881006035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881006036 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 402881006037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881006038 Coenzyme A binding pocket [chemical binding]; other site 402881006039 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 402881006040 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 402881006041 ligand binding site [chemical binding]; other site 402881006042 flexible hinge region; other site 402881006043 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 402881006044 putative switch regulator; other site 402881006045 non-specific DNA interactions [nucleotide binding]; other site 402881006046 DNA binding site [nucleotide binding] 402881006047 sequence specific DNA binding site [nucleotide binding]; other site 402881006048 putative cAMP binding site [chemical binding]; other site 402881006049 Response regulator receiver domain; Region: Response_reg; pfam00072 402881006050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006051 active site 402881006052 phosphorylation site [posttranslational modification] 402881006053 intermolecular recognition site; other site 402881006054 dimerization interface [polypeptide binding]; other site 402881006055 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 402881006056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006057 active site 402881006058 phosphorylation site [posttranslational modification] 402881006059 intermolecular recognition site; other site 402881006060 dimerization interface [polypeptide binding]; other site 402881006061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881006062 DNA binding residues [nucleotide binding] 402881006063 dimerization interface [polypeptide binding]; other site 402881006064 PAS domain S-box; Region: sensory_box; TIGR00229 402881006065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881006066 putative active site [active] 402881006067 heme pocket [chemical binding]; other site 402881006068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881006069 dimer interface [polypeptide binding]; other site 402881006070 phosphorylation site [posttranslational modification] 402881006071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881006072 ATP binding site [chemical binding]; other site 402881006073 Mg2+ binding site [ion binding]; other site 402881006074 G-X-G motif; other site 402881006075 Ion transport protein; Region: Ion_trans; pfam00520 402881006076 Predicted transcriptional regulator [Transcription]; Region: COG4190 402881006077 MarR family; Region: MarR_2; cl17246 402881006078 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 402881006079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881006080 AAA domain; Region: AAA_23; pfam13476 402881006081 Walker A/P-loop; other site 402881006082 ATP binding site [chemical binding]; other site 402881006083 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 402881006084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006085 active site 402881006086 phosphorylation site [posttranslational modification] 402881006087 intermolecular recognition site; other site 402881006088 dimerization interface [polypeptide binding]; other site 402881006089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881006090 Walker A motif; other site 402881006091 ATP binding site [chemical binding]; other site 402881006092 Walker B motif; other site 402881006093 arginine finger; other site 402881006094 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 402881006095 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 402881006096 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 402881006097 ligand binding site [chemical binding]; other site 402881006098 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 402881006099 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 402881006100 active site 402881006101 Zn binding site [ion binding]; other site 402881006102 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 402881006103 ABC1 family; Region: ABC1; cl17513 402881006104 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 402881006105 active site 402881006106 ATP binding site [chemical binding]; other site 402881006107 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881006108 CoenzymeA binding site [chemical binding]; other site 402881006109 subunit interaction site [polypeptide binding]; other site 402881006110 PHB binding site; other site 402881006111 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881006112 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881006113 Amidohydrolase; Region: Amidohydro_2; pfam04909 402881006114 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 402881006115 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 402881006116 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 402881006117 ligand binding site [chemical binding]; other site 402881006118 homodimer interface [polypeptide binding]; other site 402881006119 NAD(P) binding site [chemical binding]; other site 402881006120 trimer interface B [polypeptide binding]; other site 402881006121 trimer interface A [polypeptide binding]; other site 402881006122 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 402881006123 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 402881006124 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 402881006125 putative acetyltransferase; Provisional; Region: PRK03624 402881006126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881006127 Coenzyme A binding pocket [chemical binding]; other site 402881006128 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 402881006129 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881006130 N-terminal plug; other site 402881006131 ligand-binding site [chemical binding]; other site 402881006132 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 402881006133 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 402881006134 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 402881006135 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 402881006136 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 402881006137 active site 402881006138 catalytic residues [active] 402881006139 metal binding site [ion binding]; metal-binding site 402881006140 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 402881006141 COQ9; Region: COQ9; pfam08511 402881006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881006143 PAS domain; Region: PAS_5; pfam07310 402881006144 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 402881006145 ATP-grasp domain; Region: ATP-grasp; pfam02222 402881006146 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 402881006147 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 402881006148 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 402881006149 Walker A/P-loop; other site 402881006150 ATP binding site [chemical binding]; other site 402881006151 Q-loop/lid; other site 402881006152 ABC transporter signature motif; other site 402881006153 Walker B; other site 402881006154 D-loop; other site 402881006155 H-loop/switch region; other site 402881006156 TOBE-like domain; Region: TOBE_3; pfam12857 402881006157 sulfate transport protein; Provisional; Region: cysT; CHL00187 402881006158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881006159 dimer interface [polypeptide binding]; other site 402881006160 conserved gate region; other site 402881006161 putative PBP binding loops; other site 402881006162 ABC-ATPase subunit interface; other site 402881006163 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 402881006164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881006165 dimer interface [polypeptide binding]; other site 402881006166 conserved gate region; other site 402881006167 putative PBP binding loops; other site 402881006168 ABC-ATPase subunit interface; other site 402881006169 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 402881006170 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 402881006171 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 402881006172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 402881006173 substrate binding pocket [chemical binding]; other site 402881006174 membrane-bound complex binding site; other site 402881006175 hinge residues; other site 402881006176 Rrf2 family protein; Region: rrf2_super; TIGR00738 402881006177 Transcriptional regulator; Region: Rrf2; pfam02082 402881006178 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 402881006179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881006180 metal binding site [ion binding]; metal-binding site 402881006181 active site 402881006182 I-site; other site 402881006183 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 402881006184 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 402881006185 Flavoprotein; Region: Flavoprotein; pfam02441 402881006186 Protein of unknown function (DUF465); Region: DUF465; cl01070 402881006187 acyl-CoA synthetase; Validated; Region: PRK08162 402881006188 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 402881006189 acyl-activating enzyme (AAE) consensus motif; other site 402881006190 putative active site [active] 402881006191 AMP binding site [chemical binding]; other site 402881006192 putative CoA binding site [chemical binding]; other site 402881006193 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 402881006194 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 402881006195 acyl-activating enzyme (AAE) consensus motif; other site 402881006196 putative AMP binding site [chemical binding]; other site 402881006197 putative active site [active] 402881006198 putative CoA binding site [chemical binding]; other site 402881006199 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 402881006200 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 402881006201 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 402881006202 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881006203 MarR family; Region: MarR_2; pfam12802 402881006204 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 402881006205 hydrophobic ligand binding site; other site 402881006206 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881006207 CoenzymeA binding site [chemical binding]; other site 402881006208 subunit interaction site [polypeptide binding]; other site 402881006209 PHB binding site; other site 402881006210 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881006211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881006212 NAD(P) binding site [chemical binding]; other site 402881006213 active site 402881006214 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 402881006215 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 402881006216 putative amphipathic alpha helix; other site 402881006217 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 402881006218 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 402881006219 NAD(P) binding site [chemical binding]; other site 402881006220 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 402881006221 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 402881006222 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 402881006223 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 402881006224 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 402881006225 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 402881006226 Walker A/P-loop; other site 402881006227 ATP binding site [chemical binding]; other site 402881006228 Q-loop/lid; other site 402881006229 ABC transporter signature motif; other site 402881006230 Walker B; other site 402881006231 D-loop; other site 402881006232 H-loop/switch region; other site 402881006233 Arylesterase; Region: Arylesterase; pfam01731 402881006234 hypothetical protein; Validated; Region: PRK09039 402881006235 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 402881006236 ligand binding site [chemical binding]; other site 402881006237 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 402881006238 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 402881006239 active site 402881006240 dimerization interface [polypeptide binding]; other site 402881006241 elongation factor P; Validated; Region: PRK00529 402881006242 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 402881006243 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 402881006244 RNA binding site [nucleotide binding]; other site 402881006245 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 402881006246 RNA binding site [nucleotide binding]; other site 402881006247 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881006248 Sel1-like repeats; Region: SEL1; smart00671 402881006249 Sel1-like repeats; Region: SEL1; smart00671 402881006250 Sel1-like repeats; Region: SEL1; smart00671 402881006251 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 402881006252 thiamine phosphate binding site [chemical binding]; other site 402881006253 active site 402881006254 pyrophosphate binding site [ion binding]; other site 402881006255 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 402881006256 active site 402881006257 intersubunit interface [polypeptide binding]; other site 402881006258 catalytic residue [active] 402881006259 Phosphoglycerate kinase; Region: PGK; pfam00162 402881006260 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 402881006261 substrate binding site [chemical binding]; other site 402881006262 hinge regions; other site 402881006263 ADP binding site [chemical binding]; other site 402881006264 catalytic site [active] 402881006265 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 402881006266 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 402881006267 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 402881006268 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 402881006269 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 402881006270 TPP-binding site [chemical binding]; other site 402881006271 dimer interface [polypeptide binding]; other site 402881006272 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 402881006273 PYR/PP interface [polypeptide binding]; other site 402881006274 dimer interface [polypeptide binding]; other site 402881006275 TPP binding site [chemical binding]; other site 402881006276 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 402881006277 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 402881006278 Cell division protein ZapA; Region: ZapA; pfam05164 402881006279 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 402881006280 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 402881006281 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 402881006282 putative active site [active] 402881006283 metal binding site [ion binding]; metal-binding site 402881006284 homodimer binding site [polypeptide binding]; other site 402881006285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881006286 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 402881006287 hypothetical protein; Validated; Region: PRK00110 402881006288 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 402881006289 active site 402881006290 putative DNA-binding cleft [nucleotide binding]; other site 402881006291 dimer interface [polypeptide binding]; other site 402881006292 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 402881006293 RuvA N terminal domain; Region: RuvA_N; pfam01330 402881006294 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 402881006295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881006296 Walker A motif; other site 402881006297 ATP binding site [chemical binding]; other site 402881006298 Walker B motif; other site 402881006299 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 402881006300 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881006301 active site 402881006302 TolQ protein; Region: tolQ; TIGR02796 402881006303 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 402881006304 TolR protein; Region: tolR; TIGR02801 402881006305 translocation protein TolB; Provisional; Region: tolB; PRK05137 402881006306 TolB amino-terminal domain; Region: TolB_N; pfam04052 402881006307 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 402881006308 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 402881006309 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 402881006310 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 402881006311 ligand binding site [chemical binding]; other site 402881006312 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 402881006313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 402881006314 binding surface 402881006315 TPR motif; other site 402881006316 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 402881006317 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 402881006318 Ligand Binding Site [chemical binding]; other site 402881006319 FtsH Extracellular; Region: FtsH_ext; pfam06480 402881006320 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 402881006321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881006322 Walker A motif; other site 402881006323 ATP binding site [chemical binding]; other site 402881006324 Walker B motif; other site 402881006325 arginine finger; other site 402881006326 Peptidase family M41; Region: Peptidase_M41; pfam01434 402881006327 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 402881006328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881006329 catalytic loop [active] 402881006330 iron binding site [ion binding]; other site 402881006331 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881006332 Cytochrome P450; Region: p450; cl12078 402881006333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881006334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881006335 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 402881006336 dihydropteroate synthase; Region: DHPS; TIGR01496 402881006337 substrate binding pocket [chemical binding]; other site 402881006338 dimer interface [polypeptide binding]; other site 402881006339 inhibitor binding site; inhibition site 402881006340 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 402881006341 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 402881006342 active site 402881006343 substrate binding site [chemical binding]; other site 402881006344 metal binding site [ion binding]; metal-binding site 402881006345 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 402881006346 dimer interface [polypeptide binding]; other site 402881006347 substrate binding site [chemical binding]; other site 402881006348 ATP binding site [chemical binding]; other site 402881006349 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 402881006350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 402881006351 DNA-binding site [nucleotide binding]; DNA binding site 402881006352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881006353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881006354 homodimer interface [polypeptide binding]; other site 402881006355 catalytic residue [active] 402881006356 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 402881006357 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 402881006358 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 402881006359 EamA-like transporter family; Region: EamA; pfam00892 402881006360 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 402881006361 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881006362 catalytic residue [active] 402881006363 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 402881006364 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 402881006365 ligand binding site [chemical binding]; other site 402881006366 NAD binding site [chemical binding]; other site 402881006367 dimerization interface [polypeptide binding]; other site 402881006368 catalytic site [active] 402881006369 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 402881006370 putative L-serine binding site [chemical binding]; other site 402881006371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881006372 PAS domain; Region: PAS_5; pfam07310 402881006373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881006374 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881006375 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 402881006376 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881006377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 402881006378 OsmC-like protein; Region: OsmC; pfam02566 402881006379 Pirin-related protein [General function prediction only]; Region: COG1741 402881006380 Pirin; Region: Pirin; pfam02678 402881006381 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 402881006382 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 402881006383 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 402881006384 GDP-binding site [chemical binding]; other site 402881006385 ACT binding site; other site 402881006386 IMP binding site; other site 402881006387 MAPEG family; Region: MAPEG; cl09190 402881006388 MAPEG family; Region: MAPEG; cl09190 402881006389 Nitronate monooxygenase; Region: NMO; pfam03060 402881006390 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881006391 FMN binding site [chemical binding]; other site 402881006392 substrate binding site [chemical binding]; other site 402881006393 putative catalytic residue [active] 402881006394 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 402881006395 ThiC-associated domain; Region: ThiC-associated; pfam13667 402881006396 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 402881006397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 402881006398 active site 402881006399 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 402881006400 active site 402881006401 SUMO-1 interface [polypeptide binding]; other site 402881006402 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 402881006403 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 402881006404 active site 402881006405 putative substrate binding pocket [chemical binding]; other site 402881006406 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881006407 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 402881006408 PLD-like domain; Region: PLDc_2; pfam13091 402881006409 putative active site [active] 402881006410 catalytic site [active] 402881006411 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 402881006412 PLD-like domain; Region: PLDc_2; pfam13091 402881006413 putative active site [active] 402881006414 catalytic site [active] 402881006415 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881006416 methionine sulfoxide reductase A; Provisional; Region: PRK00058 402881006417 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 402881006418 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 402881006419 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 402881006420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881006421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881006422 DNA binding residues [nucleotide binding] 402881006423 HipA N-terminal domain; Region: Couple_hipA; cl11853 402881006424 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 402881006425 HipA-like N-terminal domain; Region: HipA_N; pfam07805 402881006426 HipA-like C-terminal domain; Region: HipA_C; pfam07804 402881006427 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881006428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881006429 non-specific DNA binding site [nucleotide binding]; other site 402881006430 salt bridge; other site 402881006431 sequence-specific DNA binding site [nucleotide binding]; other site 402881006432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 402881006433 sequence-specific DNA binding site [nucleotide binding]; other site 402881006434 salt bridge; other site 402881006435 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 402881006436 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 402881006437 RNA binding surface [nucleotide binding]; other site 402881006438 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 402881006439 active site 402881006440 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 402881006441 MAPEG family; Region: MAPEG; pfam01124 402881006442 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 402881006443 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 402881006444 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 402881006445 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 402881006446 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 402881006447 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 402881006448 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 402881006449 active site 402881006450 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 402881006451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 402881006452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006453 active site 402881006454 phosphorylation site [posttranslational modification] 402881006455 intermolecular recognition site; other site 402881006456 dimerization interface [polypeptide binding]; other site 402881006457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881006458 DNA binding site [nucleotide binding] 402881006459 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 402881006460 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 402881006461 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 402881006462 Walker A motif/ATP binding site; other site 402881006463 Walker B motif; other site 402881006464 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 402881006465 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 402881006466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 402881006467 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 402881006468 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 402881006469 FHIPEP family; Region: FHIPEP; pfam00771 402881006470 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 402881006471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881006472 Walker A motif; other site 402881006473 ATP binding site [chemical binding]; other site 402881006474 Walker B motif; other site 402881006475 arginine finger; other site 402881006476 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 402881006477 flagellar motor switch protein; Reviewed; Region: PRK08916 402881006478 flagellar assembly protein H; Validated; Region: fliH; PRK06032 402881006479 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 402881006480 FliG C-terminal domain; Region: FliG_C; pfam01706 402881006481 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 402881006482 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 402881006483 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 402881006484 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 402881006485 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 402881006486 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 402881006487 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 402881006488 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 402881006489 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 402881006490 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 402881006491 Ligand Binding Site [chemical binding]; other site 402881006492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881006493 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 402881006494 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 402881006495 active site 402881006496 SlyX; Region: SlyX; pfam04102 402881006497 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 402881006498 GIY-YIG motif/motif A; other site 402881006499 putative active site [active] 402881006500 putative metal binding site [ion binding]; other site 402881006501 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 402881006502 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881006503 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 402881006504 putative C-terminal domain interface [polypeptide binding]; other site 402881006505 putative GSH binding site (G-site) [chemical binding]; other site 402881006506 putative dimer interface [polypeptide binding]; other site 402881006507 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 402881006508 putative N-terminal domain interface [polypeptide binding]; other site 402881006509 putative dimer interface [polypeptide binding]; other site 402881006510 putative substrate binding pocket (H-site) [chemical binding]; other site 402881006511 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 402881006512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881006513 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 402881006514 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 402881006515 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 402881006516 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 402881006517 DNA-binding site [nucleotide binding]; DNA binding site 402881006518 RNA-binding motif; other site 402881006519 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 402881006520 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 402881006521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881006522 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 402881006523 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 402881006524 active site 402881006525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881006526 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 402881006527 active site 402881006528 acyl-CoA synthetase; Validated; Region: PRK07798 402881006529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881006530 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 402881006531 acyl-activating enzyme (AAE) consensus motif; other site 402881006532 acyl-activating enzyme (AAE) consensus motif; other site 402881006533 putative AMP binding site [chemical binding]; other site 402881006534 putative active site [active] 402881006535 putative CoA binding site [chemical binding]; other site 402881006536 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 402881006537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881006538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881006539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881006540 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 402881006541 Response regulator receiver domain; Region: Response_reg; pfam00072 402881006542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006543 active site 402881006544 phosphorylation site [posttranslational modification] 402881006545 intermolecular recognition site; other site 402881006546 dimerization interface [polypeptide binding]; other site 402881006547 Response regulator receiver domain; Region: Response_reg; pfam00072 402881006548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006549 active site 402881006550 phosphorylation site [posttranslational modification] 402881006551 intermolecular recognition site; other site 402881006552 dimerization interface [polypeptide binding]; other site 402881006553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881006554 S-adenosylmethionine binding site [chemical binding]; other site 402881006555 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 402881006556 nudix motif; other site 402881006557 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 402881006558 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 402881006559 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 402881006560 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 402881006561 putative dimer interface [polypeptide binding]; other site 402881006562 N-terminal domain interface [polypeptide binding]; other site 402881006563 putative substrate binding pocket (H-site) [chemical binding]; other site 402881006564 Pirin-related protein [General function prediction only]; Region: COG1741 402881006565 Pirin; Region: Pirin; pfam02678 402881006566 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 402881006567 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 402881006568 LysR family transcriptional regulator; Provisional; Region: PRK14997 402881006569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881006570 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 402881006571 putative effector binding pocket; other site 402881006572 dimerization interface [polypeptide binding]; other site 402881006573 short chain dehydrogenase; Provisional; Region: PRK07791 402881006574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881006575 NAD(P) binding site [chemical binding]; other site 402881006576 active site 402881006577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881006578 Coenzyme A binding pocket [chemical binding]; other site 402881006579 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 402881006580 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 402881006581 metal binding site [ion binding]; metal-binding site 402881006582 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 402881006583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 402881006584 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 402881006585 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 402881006586 Uncharacterized conserved protein [Function unknown]; Region: COG1742 402881006587 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 402881006588 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 402881006589 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 402881006590 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 402881006591 Protein of unknown function DUF58; Region: DUF58; pfam01882 402881006592 MoxR-like ATPases [General function prediction only]; Region: COG0714 402881006593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881006594 Walker A motif; other site 402881006595 ATP binding site [chemical binding]; other site 402881006596 Walker B motif; other site 402881006597 arginine finger; other site 402881006598 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 402881006599 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 402881006600 putative active site [active] 402881006601 putative CoA binding site [chemical binding]; other site 402881006602 nudix motif; other site 402881006603 metal binding site [ion binding]; metal-binding site 402881006604 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 402881006605 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 402881006606 active site 402881006607 NTP binding site [chemical binding]; other site 402881006608 metal binding triad [ion binding]; metal-binding site 402881006609 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 402881006610 putative lipoprotein; Provisional; Region: PRK10533 402881006611 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 402881006612 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 402881006613 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 402881006614 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 402881006615 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 402881006616 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 402881006617 [2Fe-2S] cluster binding site [ion binding]; other site 402881006618 cytochrome b; Provisional; Region: CYTB; MTH00119 402881006619 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 402881006620 Qi binding site; other site 402881006621 intrachain domain interface; other site 402881006622 interchain domain interface [polypeptide binding]; other site 402881006623 heme bH binding site [chemical binding]; other site 402881006624 heme bL binding site [chemical binding]; other site 402881006625 Qo binding site; other site 402881006626 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 402881006627 interchain domain interface [polypeptide binding]; other site 402881006628 intrachain domain interface; other site 402881006629 Qi binding site; other site 402881006630 Qo binding site; other site 402881006631 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 402881006632 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 402881006633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881006634 active site 402881006635 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 402881006636 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 402881006637 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 402881006638 intersubunit interface [polypeptide binding]; other site 402881006639 active site 402881006640 Zn2+ binding site [ion binding]; other site 402881006641 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 402881006642 catalytic residues [active] 402881006643 dimer interface [polypeptide binding]; other site 402881006644 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 402881006645 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881006646 MarR family; Region: MarR; pfam01047 402881006647 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 402881006648 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 402881006649 putative active site [active] 402881006650 putative catalytic site [active] 402881006651 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 402881006652 putative active site [active] 402881006653 putative catalytic site [active] 402881006654 GTP-binding protein YchF; Reviewed; Region: PRK09601 402881006655 YchF GTPase; Region: YchF; cd01900 402881006656 G1 box; other site 402881006657 GTP/Mg2+ binding site [chemical binding]; other site 402881006658 Switch I region; other site 402881006659 G2 box; other site 402881006660 Switch II region; other site 402881006661 G3 box; other site 402881006662 G4 box; other site 402881006663 G5 box; other site 402881006664 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 402881006665 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 402881006666 putative active site [active] 402881006667 catalytic residue [active] 402881006668 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 402881006669 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 402881006670 5S rRNA interface [nucleotide binding]; other site 402881006671 CTC domain interface [polypeptide binding]; other site 402881006672 L16 interface [polypeptide binding]; other site 402881006673 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 402881006674 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 402881006675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881006676 active site 402881006677 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 402881006678 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 402881006679 Uncharacterized conserved protein [Function unknown]; Region: COG1565 402881006680 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 402881006681 Membrane fusogenic activity; Region: BMFP; pfam04380 402881006682 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 402881006683 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 402881006684 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 402881006685 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 402881006686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881006687 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881006688 HAMP domain; Region: HAMP; pfam00672 402881006689 dimerization interface [polypeptide binding]; other site 402881006690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881006691 dimer interface [polypeptide binding]; other site 402881006692 phosphorylation site [posttranslational modification] 402881006693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881006694 ATP binding site [chemical binding]; other site 402881006695 Mg2+ binding site [ion binding]; other site 402881006696 G-X-G motif; other site 402881006697 osmolarity response regulator; Provisional; Region: ompR; PRK09468 402881006698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006699 active site 402881006700 phosphorylation site [posttranslational modification] 402881006701 intermolecular recognition site; other site 402881006702 dimerization interface [polypeptide binding]; other site 402881006703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 402881006704 DNA binding site [nucleotide binding] 402881006705 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881006706 MarR family; Region: MarR_2; pfam12802 402881006707 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 402881006708 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 402881006709 homodimer interface [polypeptide binding]; other site 402881006710 substrate-cofactor binding pocket; other site 402881006711 catalytic residue [active] 402881006712 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 402881006713 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881006714 CoenzymeA binding site [chemical binding]; other site 402881006715 subunit interaction site [polypeptide binding]; other site 402881006716 PHB binding site; other site 402881006717 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 402881006718 MoaE homodimer interface [polypeptide binding]; other site 402881006719 MoaD interaction [polypeptide binding]; other site 402881006720 active site residues [active] 402881006721 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 402881006722 MoaE interaction surface [polypeptide binding]; other site 402881006723 MoeB interaction surface [polypeptide binding]; other site 402881006724 thiocarboxylated glycine; other site 402881006725 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 402881006726 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 402881006727 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 402881006728 GIY-YIG motif/motif A; other site 402881006729 active site 402881006730 catalytic site [active] 402881006731 putative DNA binding site [nucleotide binding]; other site 402881006732 metal binding site [ion binding]; metal-binding site 402881006733 UvrB/uvrC motif; Region: UVR; pfam02151 402881006734 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 402881006735 Dihydroneopterin aldolase; Region: FolB; smart00905 402881006736 active site 402881006737 short chain dehydrogenase; Provisional; Region: PRK09134 402881006738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881006739 NAD(P) binding site [chemical binding]; other site 402881006740 active site 402881006741 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 402881006742 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 402881006743 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 402881006744 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 402881006745 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 402881006746 TrkA-N domain; Region: TrkA_N; pfam02254 402881006747 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 402881006748 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 402881006749 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 402881006750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 402881006751 short chain dehydrogenase; Provisional; Region: PRK08309 402881006752 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 402881006753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881006754 AAA domain; Region: AAA_21; pfam13304 402881006755 Walker A/P-loop; other site 402881006756 ATP binding site [chemical binding]; other site 402881006757 excinuclease ABC subunit B; Provisional; Region: PRK05298 402881006758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881006759 ATP binding site [chemical binding]; other site 402881006760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881006761 nucleotide binding region [chemical binding]; other site 402881006762 ATP-binding site [chemical binding]; other site 402881006763 Ultra-violet resistance protein B; Region: UvrB; pfam12344 402881006764 UvrB/uvrC motif; Region: UVR; pfam02151 402881006765 hypothetical protein; Provisional; Region: PRK08317 402881006766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881006767 S-adenosylmethionine binding site [chemical binding]; other site 402881006768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881006769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881006770 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 402881006771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881006772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881006773 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 402881006774 active site 402881006775 catalytic site [active] 402881006776 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 402881006777 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 402881006778 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 402881006779 metal ion-dependent adhesion site (MIDAS); other site 402881006780 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881006781 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 402881006782 putative C-terminal domain interface [polypeptide binding]; other site 402881006783 putative GSH binding site (G-site) [chemical binding]; other site 402881006784 putative dimer interface [polypeptide binding]; other site 402881006785 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881006786 N-terminal domain interface [polypeptide binding]; other site 402881006787 dimer interface [polypeptide binding]; other site 402881006788 substrate binding pocket (H-site) [chemical binding]; other site 402881006789 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 402881006790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 402881006791 DNA-binding site [nucleotide binding]; DNA binding site 402881006792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881006793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881006794 homodimer interface [polypeptide binding]; other site 402881006795 catalytic residue [active] 402881006796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 402881006797 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 402881006798 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 402881006799 aspartate aminotransferase; Provisional; Region: PRK05764 402881006800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881006801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881006802 homodimer interface [polypeptide binding]; other site 402881006803 catalytic residue [active] 402881006804 Peptidase family M48; Region: Peptidase_M48; pfam01435 402881006805 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 402881006806 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 402881006807 dimerization interface [polypeptide binding]; other site 402881006808 DPS ferroxidase diiron center [ion binding]; other site 402881006809 ion pore; other site 402881006810 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 402881006811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881006812 motif II; other site 402881006813 sulfotransferase; Region: PLN02164 402881006814 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 402881006815 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 402881006816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881006817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881006818 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 402881006819 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 402881006820 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 402881006821 dimer interface [polypeptide binding]; other site 402881006822 decamer (pentamer of dimers) interface [polypeptide binding]; other site 402881006823 catalytic triad [active] 402881006824 peroxidatic and resolving cysteines [active] 402881006825 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 402881006826 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 402881006827 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 402881006828 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 402881006829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881006830 putative DNA binding site [nucleotide binding]; other site 402881006831 putative Zn2+ binding site [ion binding]; other site 402881006832 AsnC family; Region: AsnC_trans_reg; pfam01037 402881006833 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 402881006834 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 402881006835 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 402881006836 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 402881006837 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881006838 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 402881006839 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 402881006840 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881006841 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881006842 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 402881006843 IMP binding site; other site 402881006844 dimer interface [polypeptide binding]; other site 402881006845 interdomain contacts; other site 402881006846 partial ornithine binding site; other site 402881006847 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 402881006848 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 402881006849 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 402881006850 catalytic site [active] 402881006851 subunit interface [polypeptide binding]; other site 402881006852 Yqey-like protein; Region: YqeY; pfam09424 402881006853 DNA primase, catalytic core; Region: dnaG; TIGR01391 402881006854 CHC2 zinc finger; Region: zf-CHC2; pfam01807 402881006855 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 402881006856 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 402881006857 active site 402881006858 metal binding site [ion binding]; metal-binding site 402881006859 interdomain interaction site; other site 402881006860 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 402881006861 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 402881006862 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 402881006863 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 402881006864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881006865 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 402881006866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881006867 DNA binding residues [nucleotide binding] 402881006868 Methyltransferase domain; Region: Methyltransf_31; pfam13847 402881006869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881006870 S-adenosylmethionine binding site [chemical binding]; other site 402881006871 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 402881006872 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 402881006873 conserved cys residue [active] 402881006874 Uncharacterized conserved protein [Function unknown]; Region: COG2968 402881006875 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 402881006876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881006877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881006878 stationary phase growth adaptation protein; Provisional; Region: PRK09717 402881006879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 402881006880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 402881006881 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 402881006882 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 402881006883 Autotransporter beta-domain; Region: Autotransporter; pfam03797 402881006884 two component system sensor kinase SsrB; Provisional; Region: PRK15369 402881006885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006886 active site 402881006887 phosphorylation site [posttranslational modification] 402881006888 intermolecular recognition site; other site 402881006889 dimerization interface [polypeptide binding]; other site 402881006890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881006891 DNA binding residues [nucleotide binding] 402881006892 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 402881006893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881006894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881006895 dimer interface [polypeptide binding]; other site 402881006896 phosphorylation site [posttranslational modification] 402881006897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881006898 ATP binding site [chemical binding]; other site 402881006899 Mg2+ binding site [ion binding]; other site 402881006900 G-X-G motif; other site 402881006901 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 402881006902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006903 active site 402881006904 phosphorylation site [posttranslational modification] 402881006905 intermolecular recognition site; other site 402881006906 dimerization interface [polypeptide binding]; other site 402881006907 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 402881006908 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 402881006909 active site 402881006910 DNA binding site [nucleotide binding] 402881006911 Int/Topo IB signature motif; other site 402881006912 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 402881006913 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 402881006914 active site 402881006915 metal binding site [ion binding]; metal-binding site 402881006916 DNA binding site [nucleotide binding] 402881006917 AAA domain; Region: AAA_27; pfam13514 402881006918 Protein of unknown function DUF45; Region: DUF45; pfam01863 402881006919 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 402881006920 DEAD-like helicases superfamily; Region: DEXDc; smart00487 402881006921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881006922 ATP binding site [chemical binding]; other site 402881006923 putative Mg++ binding site [ion binding]; other site 402881006924 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 402881006925 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 402881006926 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 402881006927 Virulence protein [General function prediction only]; Region: COG3943 402881006928 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 402881006929 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 402881006930 HsdM N-terminal domain; Region: HsdM_N; pfam12161 402881006931 Methyltransferase domain; Region: Methyltransf_26; pfam13659 402881006932 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 402881006933 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 402881006934 TniQ; Region: TniQ; pfam06527 402881006935 Bacterial TniB protein; Region: TniB; pfam05621 402881006936 AAA domain; Region: AAA_22; pfam13401 402881006937 Integrase core domain; Region: rve; pfam00665 402881006938 head completion protein; Provisional; Region: 4; PHA02552 402881006939 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881006940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881006941 PAS fold; Region: PAS_3; pfam08447 402881006942 putative active site [active] 402881006943 heme pocket [chemical binding]; other site 402881006944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881006945 PAS fold; Region: PAS_3; pfam08447 402881006946 putative active site [active] 402881006947 heme pocket [chemical binding]; other site 402881006948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881006949 PAS fold; Region: PAS_3; pfam08447 402881006950 putative active site [active] 402881006951 heme pocket [chemical binding]; other site 402881006952 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 402881006953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881006954 putative active site [active] 402881006955 heme pocket [chemical binding]; other site 402881006956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881006957 putative active site [active] 402881006958 heme pocket [chemical binding]; other site 402881006959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881006960 dimer interface [polypeptide binding]; other site 402881006961 phosphorylation site [posttranslational modification] 402881006962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881006963 ATP binding site [chemical binding]; other site 402881006964 Mg2+ binding site [ion binding]; other site 402881006965 G-X-G motif; other site 402881006966 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 402881006967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006968 active site 402881006969 phosphorylation site [posttranslational modification] 402881006970 intermolecular recognition site; other site 402881006971 dimerization interface [polypeptide binding]; other site 402881006972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881006973 DNA binding residues [nucleotide binding] 402881006974 dimerization interface [polypeptide binding]; other site 402881006975 Response regulator receiver domain; Region: Response_reg; pfam00072 402881006976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006977 active site 402881006978 phosphorylation site [posttranslational modification] 402881006979 intermolecular recognition site; other site 402881006980 dimerization interface [polypeptide binding]; other site 402881006981 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 402881006982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881006983 active site 402881006984 phosphorylation site [posttranslational modification] 402881006985 intermolecular recognition site; other site 402881006986 dimerization interface [polypeptide binding]; other site 402881006987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881006988 DNA binding residues [nucleotide binding] 402881006989 dimerization interface [polypeptide binding]; other site 402881006990 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 402881006991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881006992 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 402881006993 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881006994 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881006995 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 402881006996 short chain dehydrogenase; Provisional; Region: PRK06500 402881006997 classical (c) SDRs; Region: SDR_c; cd05233 402881006998 NAD(P) binding site [chemical binding]; other site 402881006999 active site 402881007000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881007001 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881007002 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 402881007003 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 402881007004 active site 402881007005 HIGH motif; other site 402881007006 dimer interface [polypeptide binding]; other site 402881007007 KMSKS motif; other site 402881007008 RES domain; Region: RES; smart00953 402881007009 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 402881007010 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 402881007011 Zeta toxin; Region: Zeta_toxin; pfam06414 402881007012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 402881007013 Pirin-related protein [General function prediction only]; Region: COG1741 402881007014 Pirin; Region: Pirin; pfam02678 402881007015 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 402881007016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881007017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881007018 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 402881007019 putative effector binding pocket; other site 402881007020 dimerization interface [polypeptide binding]; other site 402881007021 Isochorismatase family; Region: Isochorismatase; pfam00857 402881007022 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 402881007023 catalytic triad [active] 402881007024 dimer interface [polypeptide binding]; other site 402881007025 conserved cis-peptide bond; other site 402881007026 acetolactate synthase; Reviewed; Region: PRK08322 402881007027 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 402881007028 PYR/PP interface [polypeptide binding]; other site 402881007029 dimer interface [polypeptide binding]; other site 402881007030 TPP binding site [chemical binding]; other site 402881007031 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 402881007032 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 402881007033 TPP-binding site [chemical binding]; other site 402881007034 dimer interface [polypeptide binding]; other site 402881007035 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 402881007036 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881007037 NAD(P) binding site [chemical binding]; other site 402881007038 catalytic residues [active] 402881007039 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 402881007040 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 402881007041 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 402881007042 TrkA-N domain; Region: TrkA_N; pfam02254 402881007043 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 402881007044 homotrimer interaction site [polypeptide binding]; other site 402881007045 putative active site [active] 402881007046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881007047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881007048 dimer interface [polypeptide binding]; other site 402881007049 phosphorylation site [posttranslational modification] 402881007050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881007051 ATP binding site [chemical binding]; other site 402881007052 Mg2+ binding site [ion binding]; other site 402881007053 G-X-G motif; other site 402881007054 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 402881007055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881007056 active site 402881007057 phosphorylation site [posttranslational modification] 402881007058 intermolecular recognition site; other site 402881007059 dimerization interface [polypeptide binding]; other site 402881007060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881007061 DNA binding residues [nucleotide binding] 402881007062 dimerization interface [polypeptide binding]; other site 402881007063 Response regulator receiver domain; Region: Response_reg; pfam00072 402881007064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881007065 active site 402881007066 phosphorylation site [posttranslational modification] 402881007067 intermolecular recognition site; other site 402881007068 dimerization interface [polypeptide binding]; other site 402881007069 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 402881007070 Isochorismatase family; Region: Isochorismatase; pfam00857 402881007071 catalytic triad [active] 402881007072 dimer interface [polypeptide binding]; other site 402881007073 conserved cis-peptide bond; other site 402881007074 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 402881007075 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 402881007076 active site 402881007077 Transmembrane secretion effector; Region: MFS_3; pfam05977 402881007078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881007079 putative substrate translocation pore; other site 402881007080 Predicted membrane protein [Function unknown]; Region: COG2259 402881007081 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 402881007082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007083 dimerization interface [polypeptide binding]; other site 402881007084 putative DNA binding site [nucleotide binding]; other site 402881007085 putative Zn2+ binding site [ion binding]; other site 402881007086 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 402881007087 putative hydrophobic ligand binding site [chemical binding]; other site 402881007088 Protein of unknown function (DUF998); Region: DUF998; pfam06197 402881007089 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 402881007090 putative hydrophobic ligand binding site [chemical binding]; other site 402881007091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007092 dimerization interface [polypeptide binding]; other site 402881007093 putative DNA binding site [nucleotide binding]; other site 402881007094 putative Zn2+ binding site [ion binding]; other site 402881007095 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 402881007096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881007097 Walker A/P-loop; other site 402881007098 ATP binding site [chemical binding]; other site 402881007099 Q-loop/lid; other site 402881007100 ABC transporter signature motif; other site 402881007101 Walker B; other site 402881007102 D-loop; other site 402881007103 H-loop/switch region; other site 402881007104 ABC transporter; Region: ABC_tran_2; pfam12848 402881007105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 402881007106 Helix-turn-helix domain; Region: HTH_18; pfam12833 402881007107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881007108 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 402881007109 NAD(P) binding site [chemical binding]; other site 402881007110 active site 402881007111 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 402881007112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881007113 dimer interface [polypeptide binding]; other site 402881007114 phosphorylation site [posttranslational modification] 402881007115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881007116 ATP binding site [chemical binding]; other site 402881007117 Mg2+ binding site [ion binding]; other site 402881007118 G-X-G motif; other site 402881007119 Response regulator receiver domain; Region: Response_reg; pfam00072 402881007120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881007121 active site 402881007122 phosphorylation site [posttranslational modification] 402881007123 intermolecular recognition site; other site 402881007124 dimerization interface [polypeptide binding]; other site 402881007125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881007126 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 402881007127 VacJ like lipoprotein; Region: VacJ; cl01073 402881007128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007129 dimerization interface [polypeptide binding]; other site 402881007130 putative DNA binding site [nucleotide binding]; other site 402881007131 putative Zn2+ binding site [ion binding]; other site 402881007132 Methyltransferase domain; Region: Methyltransf_31; pfam13847 402881007133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881007134 S-adenosylmethionine binding site [chemical binding]; other site 402881007135 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 402881007136 FAD binding site [chemical binding]; other site 402881007137 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 402881007138 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 402881007139 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 402881007140 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 402881007141 substrate binding pocket [chemical binding]; other site 402881007142 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 402881007143 B12 binding site [chemical binding]; other site 402881007144 cobalt ligand [ion binding]; other site 402881007145 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 402881007146 Predicted transcriptional regulators [Transcription]; Region: COG1733 402881007147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007148 dimerization interface [polypeptide binding]; other site 402881007149 putative DNA binding site [nucleotide binding]; other site 402881007150 putative Zn2+ binding site [ion binding]; other site 402881007151 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 402881007152 Uncharacterized conserved protein [Function unknown]; Region: COG2128 402881007153 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 402881007154 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 402881007155 NAD(P) binding site [chemical binding]; other site 402881007156 5-oxoprolinase; Region: PLN02666 402881007157 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 402881007158 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 402881007159 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 402881007160 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 402881007161 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 402881007162 putative metal binding site [ion binding]; other site 402881007163 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 402881007164 HSP70 interaction site [polypeptide binding]; other site 402881007165 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 402881007166 EamA-like transporter family; Region: EamA; pfam00892 402881007167 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 402881007168 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 402881007169 amidase catalytic site [active] 402881007170 Zn binding residues [ion binding]; other site 402881007171 substrate binding site [chemical binding]; other site 402881007172 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 402881007173 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 402881007174 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 402881007175 NAD(P) binding site [chemical binding]; other site 402881007176 cell division protein MraZ; Reviewed; Region: PRK00326 402881007177 MraZ protein; Region: MraZ; pfam02381 402881007178 MraZ protein; Region: MraZ; pfam02381 402881007179 MraW methylase family; Region: Methyltransf_5; cl17771 402881007180 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 402881007181 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 402881007182 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 402881007183 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 402881007184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 402881007185 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 402881007186 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 402881007187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 402881007188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 402881007189 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 402881007190 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 402881007191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 402881007192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 402881007193 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 402881007194 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 402881007195 Mg++ binding site [ion binding]; other site 402881007196 putative catalytic motif [active] 402881007197 putative substrate binding site [chemical binding]; other site 402881007198 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 402881007199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 402881007200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 402881007201 cell division protein FtsW; Region: ftsW; TIGR02614 402881007202 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 402881007203 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 402881007204 active site 402881007205 homodimer interface [polypeptide binding]; other site 402881007206 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 402881007207 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 402881007208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 402881007209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 402881007210 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 402881007211 FAD binding domain; Region: FAD_binding_4; pfam01565 402881007212 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 402881007213 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 402881007214 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 402881007215 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881007216 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 402881007217 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 402881007218 Cell division protein FtsQ; Region: FtsQ; pfam03799 402881007219 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 402881007220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 402881007221 nucleotide binding site [chemical binding]; other site 402881007222 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 402881007223 Cell division protein FtsA; Region: FtsA; pfam14450 402881007224 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 402881007225 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 402881007226 nucleotide binding site [chemical binding]; other site 402881007227 SulA interaction site; other site 402881007228 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 402881007229 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 402881007230 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 402881007231 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 402881007232 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 402881007233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881007234 binding surface 402881007235 TPR motif; other site 402881007236 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 402881007237 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 402881007238 Walker A/P-loop; other site 402881007239 ATP binding site [chemical binding]; other site 402881007240 Q-loop/lid; other site 402881007241 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 402881007242 ABC transporter signature motif; other site 402881007243 Walker B; other site 402881007244 D-loop; other site 402881007245 H-loop/switch region; other site 402881007246 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 402881007247 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 402881007248 nucleotide binding pocket [chemical binding]; other site 402881007249 K-X-D-G motif; other site 402881007250 catalytic site [active] 402881007251 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 402881007252 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 402881007253 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 402881007254 Dimer interface [polypeptide binding]; other site 402881007255 BRCT sequence motif; other site 402881007256 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 402881007257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 402881007258 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 402881007259 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 402881007260 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 402881007261 active site 402881007262 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 402881007263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881007264 S-adenosylmethionine binding site [chemical binding]; other site 402881007265 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 402881007266 Part of AAA domain; Region: AAA_19; pfam13245 402881007267 Family description; Region: UvrD_C_2; pfam13538 402881007268 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 402881007269 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 402881007270 Cl- selectivity filter; other site 402881007271 Cl- binding residues [ion binding]; other site 402881007272 pore gating glutamate residue; other site 402881007273 dimer interface [polypeptide binding]; other site 402881007274 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 402881007275 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 402881007276 active site 402881007277 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 402881007278 FAD binding domain; Region: FAD_binding_4; pfam01565 402881007279 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881007280 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881007281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881007282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881007283 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 402881007284 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 402881007285 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 402881007286 fumarate hydratase; Reviewed; Region: fumC; PRK00485 402881007287 Class II fumarases; Region: Fumarase_classII; cd01362 402881007288 active site 402881007289 tetramer interface [polypeptide binding]; other site 402881007290 Stringent starvation protein B; Region: SspB; cl01120 402881007291 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 402881007292 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 402881007293 active site 402881007294 dimer interface [polypeptide binding]; other site 402881007295 thymidylate synthase; Reviewed; Region: thyA; PRK01827 402881007296 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 402881007297 dimerization interface [polypeptide binding]; other site 402881007298 active site 402881007299 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 402881007300 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 402881007301 folate binding site [chemical binding]; other site 402881007302 NADP+ binding site [chemical binding]; other site 402881007303 SnoaL-like domain; Region: SnoaL_4; pfam13577 402881007304 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 402881007305 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 402881007306 substrate binding site [chemical binding]; other site 402881007307 catalytic Zn binding site [ion binding]; other site 402881007308 NAD binding site [chemical binding]; other site 402881007309 structural Zn binding site [ion binding]; other site 402881007310 dimer interface [polypeptide binding]; other site 402881007311 S-formylglutathione hydrolase; Region: PLN02442 402881007312 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 402881007313 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 402881007314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 402881007315 hydroxyglutarate oxidase; Provisional; Region: PRK11728 402881007316 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 402881007317 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 402881007318 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 402881007319 Domain of unknown function DUF59; Region: DUF59; pfam01883 402881007320 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 402881007321 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 402881007322 Walker A motif; other site 402881007323 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 402881007324 HflK protein; Region: hflK; TIGR01933 402881007325 FtsH protease regulator HflC; Provisional; Region: PRK11029 402881007326 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 402881007327 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 402881007328 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 402881007329 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 402881007330 protein binding site [polypeptide binding]; other site 402881007331 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 402881007332 protein binding site [polypeptide binding]; other site 402881007333 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 402881007334 Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; Region: HAD-SF-IB; TIGR01488 402881007335 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 402881007336 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 402881007337 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 402881007338 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 402881007339 PYR/PP interface [polypeptide binding]; other site 402881007340 dimer interface [polypeptide binding]; other site 402881007341 TPP binding site [chemical binding]; other site 402881007342 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 402881007343 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 402881007344 TPP-binding site [chemical binding]; other site 402881007345 dimer interface [polypeptide binding]; other site 402881007346 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 402881007347 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 402881007348 putative valine binding site [chemical binding]; other site 402881007349 dimer interface [polypeptide binding]; other site 402881007350 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 402881007351 ketol-acid reductoisomerase; Provisional; Region: PRK05479 402881007352 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 402881007353 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 402881007354 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 402881007355 heme-binding site [chemical binding]; other site 402881007356 Esterase/lipase [General function prediction only]; Region: COG1647 402881007357 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 402881007358 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 402881007359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007360 dimerization interface [polypeptide binding]; other site 402881007361 putative DNA binding site [nucleotide binding]; other site 402881007362 putative Zn2+ binding site [ion binding]; other site 402881007363 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881007364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007365 putative Zn2+ binding site [ion binding]; other site 402881007366 putative DNA binding site [nucleotide binding]; other site 402881007367 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 402881007368 FMN binding site [chemical binding]; other site 402881007369 dimer interface [polypeptide binding]; other site 402881007370 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 402881007371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881007372 ATP-grasp domain; Region: ATP-grasp; pfam02222 402881007373 Predicted transcriptional regulator [Transcription]; Region: COG2378 402881007374 HTH domain; Region: HTH_11; pfam08279 402881007375 WYL domain; Region: WYL; pfam13280 402881007376 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 402881007377 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 402881007378 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 402881007379 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 402881007380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881007381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881007382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 402881007383 dimerization interface [polypeptide binding]; other site 402881007384 rod shape-determining protein MreB; Provisional; Region: PRK13927 402881007385 MreB and similar proteins; Region: MreB_like; cd10225 402881007386 nucleotide binding site [chemical binding]; other site 402881007387 Mg binding site [ion binding]; other site 402881007388 putative protofilament interaction site [polypeptide binding]; other site 402881007389 RodZ interaction site [polypeptide binding]; other site 402881007390 rod shape-determining protein MreC; Provisional; Region: PRK13922 402881007391 rod shape-determining protein MreC; Region: MreC; pfam04085 402881007392 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 402881007393 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 402881007394 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 402881007395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 402881007396 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 402881007397 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 402881007398 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 402881007399 DEAD-like helicases superfamily; Region: DEXDc; smart00487 402881007400 ATP binding site [chemical binding]; other site 402881007401 Mg++ binding site [ion binding]; other site 402881007402 motif III; other site 402881007403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881007404 nucleotide binding region [chemical binding]; other site 402881007405 ATP-binding site [chemical binding]; other site 402881007406 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 402881007407 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 402881007408 Cl binding site [ion binding]; other site 402881007409 oligomer interface [polypeptide binding]; other site 402881007410 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 402881007411 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 402881007412 serine racemase; Region: PLN02970 402881007413 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 402881007414 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881007415 catalytic residue [active] 402881007416 Methyltransferase domain; Region: Methyltransf_24; pfam13578 402881007417 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 402881007418 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 402881007419 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 402881007420 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 402881007421 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881007422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881007423 S-adenosylmethionine binding site [chemical binding]; other site 402881007424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881007425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 402881007426 SnoaL-like domain; Region: SnoaL_3; pfam13474 402881007427 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881007428 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881007429 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 402881007430 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881007431 Protein of unknown function (DUF423); Region: DUF423; pfam04241 402881007432 Phosphotransferase enzyme family; Region: APH; pfam01636 402881007433 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 402881007434 putative active site [active] 402881007435 putative substrate binding site [chemical binding]; other site 402881007436 ATP binding site [chemical binding]; other site 402881007437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881007438 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 402881007439 putative substrate translocation pore; other site 402881007440 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 402881007441 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 402881007442 active site 402881007443 iron coordination sites [ion binding]; other site 402881007444 substrate binding pocket [chemical binding]; other site 402881007445 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 402881007446 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 402881007447 putative NAD(P) binding site [chemical binding]; other site 402881007448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881007449 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 402881007450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007451 dimerization interface [polypeptide binding]; other site 402881007452 putative DNA binding site [nucleotide binding]; other site 402881007453 putative Zn2+ binding site [ion binding]; other site 402881007454 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 402881007455 putative hydrophobic ligand binding site [chemical binding]; other site 402881007456 CLM binding site; other site 402881007457 L1 loop; other site 402881007458 DNA binding site [nucleotide binding] 402881007459 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 402881007460 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 402881007461 active site 402881007462 CHASE2 domain; Region: CHASE2; pfam05226 402881007463 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 402881007464 cyclase homology domain; Region: CHD; cd07302 402881007465 nucleotidyl binding site; other site 402881007466 metal binding site [ion binding]; metal-binding site 402881007467 dimer interface [polypeptide binding]; other site 402881007468 Cytochrome c2 [Energy production and conversion]; Region: COG3474 402881007469 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 402881007470 Permease; Region: Permease; pfam02405 402881007471 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 402881007472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 402881007473 Walker A/P-loop; other site 402881007474 ATP binding site [chemical binding]; other site 402881007475 Q-loop/lid; other site 402881007476 ABC transporter signature motif; other site 402881007477 Walker B; other site 402881007478 D-loop; other site 402881007479 H-loop/switch region; other site 402881007480 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 402881007481 mce related protein; Region: MCE; pfam02470 402881007482 Protein of unknown function (DUF330); Region: DUF330; cl01135 402881007483 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 402881007484 hydroxyglutarate oxidase; Provisional; Region: PRK11728 402881007485 Predicted dehydrogenase [General function prediction only]; Region: COG0579 402881007486 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881007487 Sulfatase; Region: Sulfatase; cl17466 402881007488 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 402881007489 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881007490 catalytic loop [active] 402881007491 iron binding site [ion binding]; other site 402881007492 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 402881007493 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 402881007494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881007495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881007496 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 402881007497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 402881007498 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 402881007499 Methyltransferase domain; Region: Methyltransf_31; pfam13847 402881007500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881007501 S-adenosylmethionine binding site [chemical binding]; other site 402881007502 Uncharacterized conserved protein [Function unknown]; Region: COG4544 402881007503 DNA Polymerase Y-family; Region: PolY_like; cd03468 402881007504 active site 402881007505 DNA binding site [nucleotide binding] 402881007506 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 402881007507 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 402881007508 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 402881007509 putative active site [active] 402881007510 putative PHP Thumb interface [polypeptide binding]; other site 402881007511 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 402881007512 generic binding surface I; other site 402881007513 generic binding surface II; other site 402881007514 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 402881007515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881007516 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881007517 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 402881007518 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 402881007519 FtsX-like permease family; Region: FtsX; pfam02687 402881007520 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 402881007521 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 402881007522 Walker A/P-loop; other site 402881007523 ATP binding site [chemical binding]; other site 402881007524 Q-loop/lid; other site 402881007525 ABC transporter signature motif; other site 402881007526 Walker B; other site 402881007527 D-loop; other site 402881007528 H-loop/switch region; other site 402881007529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 402881007530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881007531 S-adenosylmethionine binding site [chemical binding]; other site 402881007532 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 402881007533 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 402881007534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881007535 Walker A motif; other site 402881007536 ATP binding site [chemical binding]; other site 402881007537 Walker B motif; other site 402881007538 arginine finger; other site 402881007539 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 402881007540 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 402881007541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 402881007542 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 402881007543 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 402881007544 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 402881007545 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 402881007546 SnoaL-like domain; Region: SnoaL_3; pfam13474 402881007547 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 402881007548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881007549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881007550 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 402881007551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881007552 NAD(P) binding site [chemical binding]; other site 402881007553 active site 402881007554 HPP family; Region: HPP; pfam04982 402881007555 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 402881007556 FOG: CBS domain [General function prediction only]; Region: COG0517 402881007557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 402881007558 Flagellar protein FlaF; Region: FlaF; pfam07309 402881007559 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 402881007560 Flagellar protein FlbT; Region: FlbT; cl11455 402881007561 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 402881007562 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 402881007563 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 402881007564 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 402881007565 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 402881007566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881007567 binding surface 402881007568 TPR motif; other site 402881007569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881007570 binding surface 402881007571 TPR motif; other site 402881007572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 402881007573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881007574 binding surface 402881007575 TPR motif; other site 402881007576 Rod binding protein; Region: Rod-binding; cl01626 402881007577 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 402881007578 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 402881007579 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 402881007580 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 402881007581 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 402881007582 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 402881007583 SAF-like; Region: SAF_2; pfam13144 402881007584 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 402881007585 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 402881007586 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 402881007587 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 402881007588 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 402881007589 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 402881007590 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 402881007591 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 402881007592 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 402881007593 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 402881007594 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 402881007595 Uncharacterized conserved protein [Function unknown]; Region: COG3334 402881007596 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 402881007597 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 402881007598 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 402881007599 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 402881007600 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 402881007601 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 402881007602 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 402881007603 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 402881007604 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 402881007605 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 402881007606 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 402881007607 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 402881007608 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 402881007609 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 402881007610 PAS domain; Region: PAS_9; pfam13426 402881007611 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 402881007612 PAS domain; Region: PAS; smart00091 402881007613 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 402881007614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881007615 dimer interface [polypeptide binding]; other site 402881007616 phosphorylation site [posttranslational modification] 402881007617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881007618 ATP binding site [chemical binding]; other site 402881007619 Mg2+ binding site [ion binding]; other site 402881007620 G-X-G motif; other site 402881007621 Response regulator receiver domain; Region: Response_reg; pfam00072 402881007622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881007623 active site 402881007624 phosphorylation site [posttranslational modification] 402881007625 intermolecular recognition site; other site 402881007626 dimerization interface [polypeptide binding]; other site 402881007627 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 402881007628 Fatty acid desaturase; Region: FA_desaturase; pfam00487 402881007629 putative di-iron ligands [ion binding]; other site 402881007630 recombinase A; Provisional; Region: recA; PRK09354 402881007631 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 402881007632 hexamer interface [polypeptide binding]; other site 402881007633 Walker A motif; other site 402881007634 ATP binding site [chemical binding]; other site 402881007635 Walker B motif; other site 402881007636 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 402881007637 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 402881007638 motif 1; other site 402881007639 active site 402881007640 motif 2; other site 402881007641 motif 3; other site 402881007642 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 402881007643 isocitrate dehydrogenase; Validated; Region: PRK08299 402881007644 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 402881007645 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 402881007646 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 402881007647 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 402881007648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 402881007649 RNA binding surface [nucleotide binding]; other site 402881007650 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 402881007651 putative GSH binding site [chemical binding]; other site 402881007652 catalytic residues [active] 402881007653 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 402881007654 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 402881007655 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 402881007656 dimerization interface [polypeptide binding]; other site 402881007657 ATP binding site [chemical binding]; other site 402881007658 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 402881007659 dimerization interface [polypeptide binding]; other site 402881007660 ATP binding site [chemical binding]; other site 402881007661 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 402881007662 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 402881007663 putative active site [active] 402881007664 catalytic triad [active] 402881007665 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 402881007666 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 402881007667 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 402881007668 ATP binding site [chemical binding]; other site 402881007669 active site 402881007670 substrate binding site [chemical binding]; other site 402881007671 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 402881007672 PAS domain; Region: PAS_5; pfam07310 402881007673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881007674 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 402881007675 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 402881007676 Trp docking motif [polypeptide binding]; other site 402881007677 putative active site [active] 402881007678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 402881007679 catalytic core [active] 402881007680 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 402881007681 putative active site [active] 402881007682 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 402881007683 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 402881007684 adenylosuccinate lyase; Provisional; Region: PRK07492 402881007685 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 402881007686 tetramer interface [polypeptide binding]; other site 402881007687 active site 402881007688 amidase; Provisional; Region: PRK07869 402881007689 Amidase; Region: Amidase; cl11426 402881007690 hypothetical protein; Reviewed; Region: PRK00024 402881007691 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 402881007692 MPN+ (JAMM) motif; other site 402881007693 Zinc-binding site [ion binding]; other site 402881007694 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 402881007695 active site 402881007696 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 402881007697 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 402881007698 putative MPT binding site; other site 402881007699 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 402881007700 choline transport protein BetT; Provisional; Region: PRK09928 402881007701 choline dehydrogenase; Validated; Region: PRK02106 402881007702 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 402881007703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 402881007704 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 402881007705 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 402881007706 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 402881007707 ligand binding site [chemical binding]; other site 402881007708 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 402881007709 putative switch regulator; other site 402881007710 non-specific DNA interactions [nucleotide binding]; other site 402881007711 DNA binding site [nucleotide binding] 402881007712 sequence specific DNA binding site [nucleotide binding]; other site 402881007713 putative cAMP binding site [chemical binding]; other site 402881007714 aldolase II superfamily protein; Provisional; Region: PRK07044 402881007715 intersubunit interface [polypeptide binding]; other site 402881007716 active site 402881007717 Zn2+ binding site [ion binding]; other site 402881007718 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 402881007719 MFS/sugar transport protein; Region: MFS_2; pfam13347 402881007720 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 402881007721 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 402881007722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881007723 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 402881007724 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 402881007725 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 402881007726 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 402881007727 metal binding site [ion binding]; metal-binding site 402881007728 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 402881007729 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881007730 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 402881007731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 402881007732 classical (c) SDRs; Region: SDR_c; cd05233 402881007733 NAD(P) binding site [chemical binding]; other site 402881007734 active site 402881007735 Domain of unknown function (DUF427); Region: DUF427; pfam04248 402881007736 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 402881007737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881007738 NAD(P) binding site [chemical binding]; other site 402881007739 active site 402881007740 enoyl-CoA hydratase; Provisional; Region: PRK06127 402881007741 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881007742 substrate binding site [chemical binding]; other site 402881007743 oxyanion hole (OAH) forming residues; other site 402881007744 trimer interface [polypeptide binding]; other site 402881007745 Sulfatase; Region: Sulfatase; cl17466 402881007746 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881007747 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 402881007748 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 402881007749 serine acetyltransferase; Provisional; Region: cysE; PRK11132 402881007750 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 402881007751 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 402881007752 trimer interface [polypeptide binding]; other site 402881007753 active site 402881007754 substrate binding site [chemical binding]; other site 402881007755 CoA binding site [chemical binding]; other site 402881007756 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 402881007757 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 402881007758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881007759 NAD(P) binding site [chemical binding]; other site 402881007760 short chain dehydrogenase; Validated; Region: PRK07069 402881007761 active site 402881007762 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 402881007763 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 402881007764 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 402881007765 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 402881007766 trimer interface [polypeptide binding]; other site 402881007767 putative metal binding site [ion binding]; other site 402881007768 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 402881007769 enoyl-CoA hydratase; Provisional; Region: PRK08140 402881007770 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881007771 substrate binding site [chemical binding]; other site 402881007772 oxyanion hole (OAH) forming residues; other site 402881007773 trimer interface [polypeptide binding]; other site 402881007774 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 402881007775 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 402881007776 enoyl-CoA hydratase; Provisional; Region: PRK06494 402881007777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881007778 substrate binding site [chemical binding]; other site 402881007779 oxyanion hole (OAH) forming residues; other site 402881007780 trimer interface [polypeptide binding]; other site 402881007781 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 402881007782 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 402881007783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881007784 substrate binding site [chemical binding]; other site 402881007785 oxyanion hole (OAH) forming residues; other site 402881007786 trimer interface [polypeptide binding]; other site 402881007787 PilZ domain; Region: PilZ; pfam07238 402881007788 PilZ domain; Region: PilZ; pfam07238 402881007789 choline dehydrogenase; Validated; Region: PRK02106 402881007790 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 402881007791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881007792 PAS domain; Region: PAS_5; pfam07310 402881007793 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 402881007794 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 402881007795 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 402881007796 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 402881007797 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 402881007798 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 402881007799 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 402881007800 putative catalytic residue [active] 402881007801 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 402881007802 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 402881007803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881007804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881007805 WHG domain; Region: WHG; pfam13305 402881007806 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 402881007807 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 402881007808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881007809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881007810 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 402881007811 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 402881007812 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 402881007813 FOG: CBS domain [General function prediction only]; Region: COG0517 402881007814 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 402881007815 hypothetical protein; Provisional; Region: PRK10279 402881007816 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 402881007817 active site 402881007818 nucleophile elbow; other site 402881007819 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 402881007820 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 402881007821 GTP cyclohydrolase I; Provisional; Region: PLN03044 402881007822 active site 402881007823 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 402881007824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 402881007825 active site 402881007826 HIGH motif; other site 402881007827 nucleotide binding site [chemical binding]; other site 402881007828 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 402881007829 KMSKS motif; other site 402881007830 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 402881007831 tRNA binding surface [nucleotide binding]; other site 402881007832 anticodon binding site; other site 402881007833 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 402881007834 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 402881007835 trimerization site [polypeptide binding]; other site 402881007836 active site 402881007837 hypothetical protein; Validated; Region: PRK00041 402881007838 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 402881007839 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 402881007840 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 402881007841 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 402881007842 active site 402881007843 dimer interface [polypeptide binding]; other site 402881007844 motif 1; other site 402881007845 motif 2; other site 402881007846 motif 3; other site 402881007847 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 402881007848 anticodon binding site; other site 402881007849 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 402881007850 dimer interface [polypeptide binding]; other site 402881007851 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 402881007852 putative hydrophobic ligand binding site [chemical binding]; other site 402881007853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881007854 dimerization interface [polypeptide binding]; other site 402881007855 putative DNA binding site [nucleotide binding]; other site 402881007856 putative Zn2+ binding site [ion binding]; other site 402881007857 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 402881007858 putative FMN binding site [chemical binding]; other site 402881007859 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 402881007860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881007861 motif II; other site 402881007862 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 402881007863 TPR repeat; Region: TPR_11; pfam13414 402881007864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881007865 binding surface 402881007866 TPR motif; other site 402881007867 TPR repeat; Region: TPR_11; pfam13414 402881007868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881007869 Tetratricopeptide repeat; Region: TPR_16; pfam13432 402881007870 TPR motif; other site 402881007871 binding surface 402881007872 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 402881007873 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 402881007874 Chromate transporter; Region: Chromate_transp; pfam02417 402881007875 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 402881007876 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 402881007877 active site 402881007878 putative substrate binding pocket [chemical binding]; other site 402881007879 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881007880 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 402881007881 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 402881007882 putative ligand binding site [chemical binding]; other site 402881007883 NAD binding site [chemical binding]; other site 402881007884 catalytic site [active] 402881007885 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 402881007886 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 402881007887 putative active site [active] 402881007888 putative catalytic site [active] 402881007889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881007890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881007891 active site 402881007892 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 402881007893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881007894 Response regulator receiver domain; Region: Response_reg; pfam00072 402881007895 active site 402881007896 phosphorylation site [posttranslational modification] 402881007897 intermolecular recognition site; other site 402881007898 dimerization interface [polypeptide binding]; other site 402881007899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881007900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881007901 putative substrate translocation pore; other site 402881007902 Transcriptional regulator; Region: Rrf2; cl17282 402881007903 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 402881007904 apolar tunnel; other site 402881007905 heme binding site [chemical binding]; other site 402881007906 dimerization interface [polypeptide binding]; other site 402881007907 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 402881007908 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 402881007909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881007910 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 402881007911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881007912 motif II; other site 402881007913 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 402881007914 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 402881007915 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881007916 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881007917 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 402881007918 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881007919 carboxyltransferase (CT) interaction site; other site 402881007920 biotinylation site [posttranslational modification]; other site 402881007921 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 402881007922 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 402881007923 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 402881007924 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 402881007925 active site 402881007926 FMN binding site [chemical binding]; other site 402881007927 substrate binding site [chemical binding]; other site 402881007928 putative catalytic residue [active] 402881007929 putative S-transferase; Provisional; Region: PRK11752 402881007930 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 402881007931 C-terminal domain interface [polypeptide binding]; other site 402881007932 GSH binding site (G-site) [chemical binding]; other site 402881007933 dimer interface [polypeptide binding]; other site 402881007934 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 402881007935 dimer interface [polypeptide binding]; other site 402881007936 N-terminal domain interface [polypeptide binding]; other site 402881007937 active site 402881007938 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 402881007939 CoA-transferase family III; Region: CoA_transf_3; pfam02515 402881007940 Predicted membrane protein [Function unknown]; Region: COG2259 402881007941 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 402881007942 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 402881007943 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881007944 dimer interface [polypeptide binding]; other site 402881007945 active site 402881007946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 402881007947 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 402881007948 nudix motif; other site 402881007949 ATP-NAD kinase; Region: NAD_kinase; pfam01513 402881007950 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 402881007951 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 402881007952 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 402881007953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881007954 FeS/SAM binding site; other site 402881007955 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 402881007956 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 402881007957 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 402881007958 N- and C-terminal domain interface [polypeptide binding]; other site 402881007959 active site 402881007960 MgATP binding site [chemical binding]; other site 402881007961 catalytic site [active] 402881007962 metal binding site [ion binding]; metal-binding site 402881007963 glycerol binding site [chemical binding]; other site 402881007964 homotetramer interface [polypeptide binding]; other site 402881007965 homodimer interface [polypeptide binding]; other site 402881007966 FBP binding site [chemical binding]; other site 402881007967 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 402881007968 FAD binding domain; Region: FAD_binding_4; pfam01565 402881007969 aldolase II superfamily protein; Provisional; Region: PRK07044 402881007970 intersubunit interface [polypeptide binding]; other site 402881007971 active site 402881007972 Zn2+ binding site [ion binding]; other site 402881007973 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 402881007974 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 402881007975 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 402881007976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881007977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881007978 S-adenosylmethionine binding site [chemical binding]; other site 402881007979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881007980 benzoate transport; Region: 2A0115; TIGR00895 402881007981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881007982 putative substrate translocation pore; other site 402881007983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881007984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881007985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881007986 hypothetical protein; Provisional; Region: PRK06194 402881007987 classical (c) SDRs; Region: SDR_c; cd05233 402881007988 NAD(P) binding site [chemical binding]; other site 402881007989 active site 402881007990 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 402881007991 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 402881007992 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 402881007993 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 402881007994 aminotransferase; Validated; Region: PRK07046 402881007995 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 402881007996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881007997 catalytic residue [active] 402881007998 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 402881007999 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 402881008000 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 402881008001 elongation factor Tu; Reviewed; Region: PRK00049 402881008002 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 402881008003 G1 box; other site 402881008004 GEF interaction site [polypeptide binding]; other site 402881008005 GTP/Mg2+ binding site [chemical binding]; other site 402881008006 Switch I region; other site 402881008007 G2 box; other site 402881008008 G3 box; other site 402881008009 Switch II region; other site 402881008010 G4 box; other site 402881008011 G5 box; other site 402881008012 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 402881008013 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 402881008014 Antibiotic Binding Site [chemical binding]; other site 402881008015 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 402881008016 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 402881008017 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 402881008018 putative homodimer interface [polypeptide binding]; other site 402881008019 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 402881008020 heterodimer interface [polypeptide binding]; other site 402881008021 homodimer interface [polypeptide binding]; other site 402881008022 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 402881008023 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 402881008024 23S rRNA interface [nucleotide binding]; other site 402881008025 L7/L12 interface [polypeptide binding]; other site 402881008026 putative thiostrepton binding site; other site 402881008027 L25 interface [polypeptide binding]; other site 402881008028 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 402881008029 mRNA/rRNA interface [nucleotide binding]; other site 402881008030 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 402881008031 23S rRNA interface [nucleotide binding]; other site 402881008032 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 402881008033 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 402881008034 core dimer interface [polypeptide binding]; other site 402881008035 peripheral dimer interface [polypeptide binding]; other site 402881008036 L10 interface [polypeptide binding]; other site 402881008037 L11 interface [polypeptide binding]; other site 402881008038 putative EF-Tu interaction site [polypeptide binding]; other site 402881008039 putative EF-G interaction site [polypeptide binding]; other site 402881008040 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 402881008041 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 402881008042 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 402881008043 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 402881008044 RPB12 interaction site [polypeptide binding]; other site 402881008045 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 402881008046 RPB1 interaction site [polypeptide binding]; other site 402881008047 RPB11 interaction site [polypeptide binding]; other site 402881008048 RPB10 interaction site [polypeptide binding]; other site 402881008049 RPB3 interaction site [polypeptide binding]; other site 402881008050 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 402881008051 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 402881008052 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 402881008053 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 402881008054 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 402881008055 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 402881008056 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 402881008057 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 402881008058 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 402881008059 DNA binding site [nucleotide binding] 402881008060 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 402881008061 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 402881008062 S17 interaction site [polypeptide binding]; other site 402881008063 S8 interaction site; other site 402881008064 16S rRNA interaction site [nucleotide binding]; other site 402881008065 streptomycin interaction site [chemical binding]; other site 402881008066 23S rRNA interaction site [nucleotide binding]; other site 402881008067 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 402881008068 30S ribosomal protein S7; Validated; Region: PRK05302 402881008069 elongation factor G; Reviewed; Region: PRK00007 402881008070 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 402881008071 G1 box; other site 402881008072 putative GEF interaction site [polypeptide binding]; other site 402881008073 GTP/Mg2+ binding site [chemical binding]; other site 402881008074 Switch I region; other site 402881008075 G2 box; other site 402881008076 G3 box; other site 402881008077 Switch II region; other site 402881008078 G4 box; other site 402881008079 G5 box; other site 402881008080 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 402881008081 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 402881008082 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 402881008083 elongation factor Tu; Reviewed; Region: PRK00049 402881008084 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 402881008085 G1 box; other site 402881008086 GEF interaction site [polypeptide binding]; other site 402881008087 GTP/Mg2+ binding site [chemical binding]; other site 402881008088 Switch I region; other site 402881008089 G2 box; other site 402881008090 G3 box; other site 402881008091 Switch II region; other site 402881008092 G4 box; other site 402881008093 G5 box; other site 402881008094 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 402881008095 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 402881008096 Antibiotic Binding Site [chemical binding]; other site 402881008097 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 402881008098 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 402881008099 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 402881008100 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 402881008101 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 402881008102 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 402881008103 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 402881008104 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 402881008105 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 402881008106 putative translocon binding site; other site 402881008107 protein-rRNA interface [nucleotide binding]; other site 402881008108 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 402881008109 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 402881008110 G-X-X-G motif; other site 402881008111 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 402881008112 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 402881008113 23S rRNA interface [nucleotide binding]; other site 402881008114 5S rRNA interface [nucleotide binding]; other site 402881008115 putative antibiotic binding site [chemical binding]; other site 402881008116 L25 interface [polypeptide binding]; other site 402881008117 L27 interface [polypeptide binding]; other site 402881008118 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 402881008119 23S rRNA interface [nucleotide binding]; other site 402881008120 putative translocon interaction site; other site 402881008121 signal recognition particle (SRP54) interaction site; other site 402881008122 L23 interface [polypeptide binding]; other site 402881008123 trigger factor interaction site; other site 402881008124 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 402881008125 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 402881008126 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 402881008127 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 402881008128 RNA binding site [nucleotide binding]; other site 402881008129 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 402881008130 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 402881008131 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 402881008132 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 402881008133 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 402881008134 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 402881008135 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 402881008136 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 402881008137 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 402881008138 5S rRNA interface [nucleotide binding]; other site 402881008139 23S rRNA interface [nucleotide binding]; other site 402881008140 L5 interface [polypeptide binding]; other site 402881008141 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 402881008142 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 402881008143 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 402881008144 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 402881008145 23S rRNA binding site [nucleotide binding]; other site 402881008146 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 402881008147 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 402881008148 SecY translocase; Region: SecY; pfam00344 402881008149 adenylate kinase; Reviewed; Region: adk; PRK00279 402881008150 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 402881008151 AMP-binding site [chemical binding]; other site 402881008152 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 402881008153 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 402881008154 30S ribosomal protein S13; Region: bact_S13; TIGR03631 402881008155 30S ribosomal protein S11; Validated; Region: PRK05309 402881008156 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 402881008157 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 402881008158 alphaNTD - beta interaction site [polypeptide binding]; other site 402881008159 alphaNTD homodimer interface [polypeptide binding]; other site 402881008160 alphaNTD - beta' interaction site [polypeptide binding]; other site 402881008161 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 402881008162 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 402881008163 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 402881008164 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 402881008165 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 402881008166 protein binding site [polypeptide binding]; other site 402881008167 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 402881008168 protein binding site [polypeptide binding]; other site 402881008169 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 402881008170 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 402881008171 heme binding site [chemical binding]; other site 402881008172 ferroxidase pore; other site 402881008173 ferroxidase diiron center [ion binding]; other site 402881008174 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 402881008175 recombination factor protein RarA; Reviewed; Region: PRK13342 402881008176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881008177 Walker A motif; other site 402881008178 ATP binding site [chemical binding]; other site 402881008179 Walker B motif; other site 402881008180 arginine finger; other site 402881008181 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 402881008182 camphor resistance protein CrcB; Provisional; Region: PRK14195 402881008183 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 402881008184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 402881008185 RNA binding surface [nucleotide binding]; other site 402881008186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 402881008187 active site 402881008188 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 402881008189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 402881008190 motif II; other site 402881008191 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 402881008192 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 402881008193 ATP12 chaperone protein; Region: ATP12; cl02228 402881008194 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 402881008195 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 402881008196 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 402881008197 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 402881008198 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881008199 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 402881008200 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 402881008201 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881008202 carboxyltransferase (CT) interaction site; other site 402881008203 biotinylation site [posttranslational modification]; other site 402881008204 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 402881008205 lipoate-protein ligase B; Provisional; Region: PRK14341 402881008206 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 402881008207 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 402881008208 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 402881008209 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 402881008210 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 402881008211 Active Sites [active] 402881008212 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 402881008213 MgtE intracellular N domain; Region: MgtE_N; smart00924 402881008214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 402881008215 Divalent cation transporter; Region: MgtE; pfam01769 402881008216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 402881008217 Kelch motif; Region: Kelch_1; pfam01344 402881008218 Kelch domain; Region: Kelch; smart00612 402881008219 Kelch motif; Region: Kelch_1; pfam01344 402881008220 Kelch domain; Region: Kelch; smart00612 402881008221 Galactose oxidase, central domain; Region: Kelch_3; cl02701 402881008222 isovaleryl-CoA dehydrogenase; Region: PLN02519 402881008223 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 402881008224 substrate binding site [chemical binding]; other site 402881008225 FAD binding site [chemical binding]; other site 402881008226 catalytic base [active] 402881008227 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881008228 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881008229 C-terminal domain interface [polypeptide binding]; other site 402881008230 GSH binding site (G-site) [chemical binding]; other site 402881008231 dimer interface [polypeptide binding]; other site 402881008232 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881008233 N-terminal domain interface [polypeptide binding]; other site 402881008234 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 402881008235 active site 402881008236 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 402881008237 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 402881008238 dimer interface [polypeptide binding]; other site 402881008239 active site 402881008240 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881008241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881008242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881008243 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 402881008244 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 402881008245 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 402881008246 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 402881008247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881008248 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881008249 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 402881008250 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881008251 carboxyltransferase (CT) interaction site; other site 402881008252 biotinylation site [posttranslational modification]; other site 402881008253 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 402881008254 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 402881008255 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881008256 pantoate--beta-alanine ligase; Region: panC; TIGR00018 402881008257 Pantoate-beta-alanine ligase; Region: PanC; cd00560 402881008258 active site 402881008259 ATP-binding site [chemical binding]; other site 402881008260 pantoate-binding site; other site 402881008261 HXXH motif; other site 402881008262 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 402881008263 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 402881008264 putative active site [active] 402881008265 metal binding site [ion binding]; metal-binding site 402881008266 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 402881008267 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 402881008268 NAD(P) binding site [chemical binding]; other site 402881008269 catalytic residues [active] 402881008270 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 402881008271 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 402881008272 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 402881008273 ATPase MipZ; Region: MipZ; pfam09140 402881008274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881008275 P-loop; other site 402881008276 Magnesium ion binding site [ion binding]; other site 402881008277 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 402881008278 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 402881008279 Sporulation related domain; Region: SPOR; pfam05036 402881008280 Uncharacterized conserved protein [Function unknown]; Region: COG2127 402881008281 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 402881008282 Clp amino terminal domain; Region: Clp_N; pfam02861 402881008283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881008284 Walker A motif; other site 402881008285 ATP binding site [chemical binding]; other site 402881008286 Walker B motif; other site 402881008287 arginine finger; other site 402881008288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881008289 Walker A motif; other site 402881008290 ATP binding site [chemical binding]; other site 402881008291 Walker B motif; other site 402881008292 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 402881008293 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 402881008294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881008295 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 402881008296 PQQ-like domain; Region: PQQ_2; pfam13360 402881008297 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 402881008298 HIT family signature motif; other site 402881008299 catalytic residue [active] 402881008300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 402881008301 Protein of unknown function, DUF482; Region: DUF482; pfam04339 402881008302 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 402881008303 homotrimer interaction site [polypeptide binding]; other site 402881008304 putative active site [active] 402881008305 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 402881008306 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 402881008307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 402881008308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881008309 metal binding site [ion binding]; metal-binding site 402881008310 active site 402881008311 I-site; other site 402881008312 Uncharacterized conserved protein [Function unknown]; Region: COG1262 402881008313 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 402881008314 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 402881008315 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 402881008316 dimerization interface [polypeptide binding]; other site 402881008317 ligand binding site [chemical binding]; other site 402881008318 NADP binding site [chemical binding]; other site 402881008319 catalytic site [active] 402881008320 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 402881008321 DNA polymerase IV; Provisional; Region: PRK02794 402881008322 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 402881008323 active site 402881008324 DNA binding site [nucleotide binding] 402881008325 fructokinase; Reviewed; Region: PRK09557 402881008326 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 402881008327 nucleotide binding site [chemical binding]; other site 402881008328 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 402881008329 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 402881008330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881008331 active site 402881008332 phosphorylation site [posttranslational modification] 402881008333 intermolecular recognition site; other site 402881008334 dimerization interface [polypeptide binding]; other site 402881008335 response regulator PleD; Reviewed; Region: pleD; PRK09581 402881008336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881008337 active site 402881008338 phosphorylation site [posttranslational modification] 402881008339 intermolecular recognition site; other site 402881008340 dimerization interface [polypeptide binding]; other site 402881008341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881008342 active site 402881008343 phosphorylation site [posttranslational modification] 402881008344 intermolecular recognition site; other site 402881008345 dimerization interface [polypeptide binding]; other site 402881008346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881008347 metal binding site [ion binding]; metal-binding site 402881008348 active site 402881008349 I-site; other site 402881008350 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 402881008351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881008352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881008353 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 402881008354 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 402881008355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881008356 catalytic residue [active] 402881008357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881008358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881008359 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 402881008360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881008361 putative DNA binding site [nucleotide binding]; other site 402881008362 putative Zn2+ binding site [ion binding]; other site 402881008363 AsnC family; Region: AsnC_trans_reg; pfam01037 402881008364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881008365 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 402881008366 putative C-terminal domain interface [polypeptide binding]; other site 402881008367 putative GSH binding site (G-site) [chemical binding]; other site 402881008368 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881008369 putative dimer interface [polypeptide binding]; other site 402881008370 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881008371 N-terminal domain interface [polypeptide binding]; other site 402881008372 substrate binding pocket (H-site) [chemical binding]; other site 402881008373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881008374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881008375 putative substrate translocation pore; other site 402881008376 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 402881008377 nudix motif; other site 402881008378 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 402881008379 nudix motif; other site 402881008380 Protein of unknown function (DUF983); Region: DUF983; cl02211 402881008381 ribonuclease R; Region: RNase_R; TIGR02063 402881008382 RNB domain; Region: RNB; pfam00773 402881008383 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 402881008384 RNA binding site [nucleotide binding]; other site 402881008385 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 402881008386 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 402881008387 active site 402881008388 interdomain interaction site; other site 402881008389 putative metal-binding site [ion binding]; other site 402881008390 nucleotide binding site [chemical binding]; other site 402881008391 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 402881008392 domain I; other site 402881008393 DNA binding groove [nucleotide binding] 402881008394 phosphate binding site [ion binding]; other site 402881008395 domain II; other site 402881008396 domain III; other site 402881008397 nucleotide binding site [chemical binding]; other site 402881008398 catalytic site [active] 402881008399 domain IV; other site 402881008400 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 402881008401 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 402881008402 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 402881008403 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 402881008404 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 402881008405 DNA protecting protein DprA; Region: dprA; TIGR00732 402881008406 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 402881008407 dihydroorotase; Validated; Region: PRK09059 402881008408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 402881008409 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 402881008410 active site 402881008411 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 402881008412 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 402881008413 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 402881008414 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 402881008415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 402881008416 active site 402881008417 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 402881008418 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 402881008419 Predicted permeases [General function prediction only]; Region: COG0679 402881008420 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 402881008421 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 402881008422 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 402881008423 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 402881008424 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 402881008425 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 402881008426 GatB domain; Region: GatB_Yqey; smart00845 402881008427 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 402881008428 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 402881008429 C-terminal domain interface [polypeptide binding]; other site 402881008430 GSH binding site (G-site) [chemical binding]; other site 402881008431 dimer interface [polypeptide binding]; other site 402881008432 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 402881008433 N-terminal domain interface [polypeptide binding]; other site 402881008434 putative dimer interface [polypeptide binding]; other site 402881008435 active site 402881008436 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881008437 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 402881008438 C-terminal domain interface [polypeptide binding]; other site 402881008439 GSH binding site (G-site) [chemical binding]; other site 402881008440 dimer interface [polypeptide binding]; other site 402881008441 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881008442 N-terminal domain interface [polypeptide binding]; other site 402881008443 dimer interface [polypeptide binding]; other site 402881008444 substrate binding pocket (H-site) [chemical binding]; other site 402881008445 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881008446 Sel1-like repeats; Region: SEL1; smart00671 402881008447 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 402881008448 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 402881008449 active site 402881008450 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 402881008451 catalytic triad [active] 402881008452 dimer interface [polypeptide binding]; other site 402881008453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 402881008454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881008455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 402881008456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 402881008457 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 402881008458 MFS/sugar transport protein; Region: MFS_2; pfam13347 402881008459 Predicted membrane protein [Function unknown]; Region: COG2860 402881008460 UPF0126 domain; Region: UPF0126; pfam03458 402881008461 UPF0126 domain; Region: UPF0126; pfam03458 402881008462 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 402881008463 Mechanosensitive ion channel; Region: MS_channel; pfam00924 402881008464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881008465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881008466 S-adenosylmethionine binding site [chemical binding]; other site 402881008467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881008468 S-adenosylmethionine binding site [chemical binding]; other site 402881008469 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 402881008470 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 402881008471 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 402881008472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881008473 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 402881008474 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881008475 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881008476 catalytic residue [active] 402881008477 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 402881008478 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 402881008479 dimer interface [polypeptide binding]; other site 402881008480 active site 402881008481 catalytic residue [active] 402881008482 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 402881008483 SmpB-tmRNA interface; other site 402881008484 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 402881008485 Fe-S cluster binding site [ion binding]; other site 402881008486 DNA binding site [nucleotide binding] 402881008487 active site 402881008488 Uncharacterized conserved protein [Function unknown]; Region: COG1432 402881008489 LabA_like proteins; Region: LabA; cd10911 402881008490 putative metal binding site [ion binding]; other site 402881008491 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 402881008492 catalytic center binding site [active] 402881008493 ATP binding site [chemical binding]; other site 402881008494 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 402881008495 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 402881008496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 402881008497 Zn2+ binding site [ion binding]; other site 402881008498 Mg2+ binding site [ion binding]; other site 402881008499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 402881008500 synthetase active site [active] 402881008501 NTP binding site [chemical binding]; other site 402881008502 metal binding site [ion binding]; metal-binding site 402881008503 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 402881008504 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 402881008505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881008506 active site 402881008507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 402881008508 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 402881008509 active site 402881008510 hydrophilic channel; other site 402881008511 dimerization interface [polypeptide binding]; other site 402881008512 catalytic residues [active] 402881008513 active site lid [active] 402881008514 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 402881008515 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 402881008516 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 402881008517 Catalytic site [active] 402881008518 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 402881008519 ribonuclease III; Reviewed; Region: rnc; PRK00102 402881008520 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 402881008521 dimerization interface [polypeptide binding]; other site 402881008522 active site 402881008523 metal binding site [ion binding]; metal-binding site 402881008524 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 402881008525 dsRNA binding site [nucleotide binding]; other site 402881008526 GTPase Era; Reviewed; Region: era; PRK00089 402881008527 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 402881008528 G1 box; other site 402881008529 GTP/Mg2+ binding site [chemical binding]; other site 402881008530 Switch I region; other site 402881008531 G2 box; other site 402881008532 Switch II region; other site 402881008533 G3 box; other site 402881008534 G4 box; other site 402881008535 G5 box; other site 402881008536 KH domain; Region: KH_2; pfam07650 402881008537 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 402881008538 Recombination protein O N terminal; Region: RecO_N; pfam11967 402881008539 Recombination protein O C terminal; Region: RecO_C; pfam02565 402881008540 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 402881008541 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 402881008542 CAP-like domain; other site 402881008543 active site 402881008544 primary dimer interface [polypeptide binding]; other site 402881008545 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 402881008546 GIY-YIG motif/motif A; other site 402881008547 putative active site [active] 402881008548 putative metal binding site [ion binding]; other site 402881008549 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 402881008550 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 402881008551 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 402881008552 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 402881008553 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 402881008554 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 402881008555 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 402881008556 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 402881008557 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 402881008558 transmembrane helices; other site 402881008559 TrkA-C domain; Region: TrkA_C; pfam02080 402881008560 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 402881008561 TrkA-C domain; Region: TrkA_C; pfam02080 402881008562 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 402881008563 RDD family; Region: RDD; pfam06271 402881008564 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 402881008565 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 402881008566 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 402881008567 ligand binding site [chemical binding]; other site 402881008568 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 402881008569 flagellar motor protein MotA; Validated; Region: PRK09110 402881008570 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 402881008571 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881008572 MarR family; Region: MarR_2; pfam12802 402881008573 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 402881008574 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 402881008575 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 402881008576 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 402881008577 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 402881008578 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 402881008579 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 402881008580 active site 402881008581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 402881008582 dimer interface [polypeptide binding]; other site 402881008583 catalytic residues [active] 402881008584 substrate binding site [chemical binding]; other site 402881008585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 402881008586 WHG domain; Region: WHG; pfam13305 402881008587 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 402881008588 dimer interface [polypeptide binding]; other site 402881008589 allosteric magnesium binding site [ion binding]; other site 402881008590 active site 402881008591 aspartate-rich active site metal binding site; other site 402881008592 Schiff base residues; other site 402881008593 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 402881008594 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 402881008595 substrate binding pocket [chemical binding]; other site 402881008596 FAD binding site [chemical binding]; other site 402881008597 catalytic base [active] 402881008598 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 402881008599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881008600 substrate binding site [chemical binding]; other site 402881008601 oxyanion hole (OAH) forming residues; other site 402881008602 trimer interface [polypeptide binding]; other site 402881008603 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 402881008604 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 402881008605 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 402881008606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 402881008607 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 402881008608 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 402881008609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 402881008610 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 402881008611 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 402881008612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 402881008613 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 402881008614 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 402881008615 putative active site [active] 402881008616 catalytic site [active] 402881008617 putative metal binding site [ion binding]; other site 402881008618 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 402881008619 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 402881008620 substrate-cofactor binding pocket; other site 402881008621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881008622 catalytic residue [active] 402881008623 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 402881008624 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 402881008625 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 402881008626 dimer interface [polypeptide binding]; other site 402881008627 active site 402881008628 glycine-pyridoxal phosphate binding site [chemical binding]; other site 402881008629 folate binding site [chemical binding]; other site 402881008630 transcriptional regulator NrdR; Region: TIGR00244 402881008631 ATP cone domain; Region: ATP-cone; pfam03477 402881008632 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 402881008633 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 402881008634 catalytic motif [active] 402881008635 Zn binding site [ion binding]; other site 402881008636 RibD C-terminal domain; Region: RibD_C; cl17279 402881008637 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 402881008638 Lumazine binding domain; Region: Lum_binding; pfam00677 402881008639 Lumazine binding domain; Region: Lum_binding; pfam00677 402881008640 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 402881008641 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 402881008642 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 402881008643 dimerization interface [polypeptide binding]; other site 402881008644 active site 402881008645 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 402881008646 homopentamer interface [polypeptide binding]; other site 402881008647 active site 402881008648 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 402881008649 thiamine monophosphate kinase; Provisional; Region: PRK05731 402881008650 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 402881008651 ATP binding site [chemical binding]; other site 402881008652 dimerization interface [polypeptide binding]; other site 402881008653 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 402881008654 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 402881008655 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 402881008656 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 402881008657 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 402881008658 TrkA-N domain; Region: TrkA_N; pfam02254 402881008659 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881008660 Ligand Binding Site [chemical binding]; other site 402881008661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881008662 Ligand Binding Site [chemical binding]; other site 402881008663 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 402881008664 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 402881008665 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 402881008666 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 402881008667 putative phosphate acyltransferase; Provisional; Region: PRK05331 402881008668 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 402881008669 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 402881008670 dimer interface [polypeptide binding]; other site 402881008671 active site 402881008672 CoA binding pocket [chemical binding]; other site 402881008673 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 402881008674 IHF dimer interface [polypeptide binding]; other site 402881008675 IHF - DNA interface [nucleotide binding]; other site 402881008676 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 402881008677 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 402881008678 DNA binding residues [nucleotide binding] 402881008679 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 402881008680 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 402881008681 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 402881008682 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 402881008683 ADP-ribose binding site [chemical binding]; other site 402881008684 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881008685 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 402881008686 C-terminal domain interface [polypeptide binding]; other site 402881008687 GSH binding site (G-site) [chemical binding]; other site 402881008688 dimer interface [polypeptide binding]; other site 402881008689 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 402881008690 N-terminal domain interface [polypeptide binding]; other site 402881008691 dimer interface [polypeptide binding]; other site 402881008692 substrate binding pocket (H-site) [chemical binding]; other site 402881008693 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 402881008694 putative hydrophobic ligand binding site [chemical binding]; other site 402881008695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881008696 dimerization interface [polypeptide binding]; other site 402881008697 putative DNA binding site [nucleotide binding]; other site 402881008698 putative Zn2+ binding site [ion binding]; other site 402881008699 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 402881008700 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 402881008701 homodimer interface [polypeptide binding]; other site 402881008702 substrate-cofactor binding pocket; other site 402881008703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881008704 catalytic residue [active] 402881008705 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 402881008706 enoyl-CoA hydratase; Validated; Region: PRK08139 402881008707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881008708 substrate binding site [chemical binding]; other site 402881008709 oxyanion hole (OAH) forming residues; other site 402881008710 trimer interface [polypeptide binding]; other site 402881008711 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881008712 CoenzymeA binding site [chemical binding]; other site 402881008713 subunit interaction site [polypeptide binding]; other site 402881008714 PHB binding site; other site 402881008715 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 402881008716 23S rRNA interface [nucleotide binding]; other site 402881008717 L3 interface [polypeptide binding]; other site 402881008718 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 402881008719 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 402881008720 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 402881008721 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 402881008722 EamA-like transporter family; Region: EamA; pfam00892 402881008723 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 402881008724 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 402881008725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881008726 sequence-specific DNA binding site [nucleotide binding]; other site 402881008727 salt bridge; other site 402881008728 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 402881008729 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 402881008730 aminotransferase; Validated; Region: PRK09148 402881008731 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881008732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881008733 homodimer interface [polypeptide binding]; other site 402881008734 catalytic residue [active] 402881008735 homoserine dehydrogenase; Provisional; Region: PRK06349 402881008736 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 402881008737 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 402881008738 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 402881008739 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 402881008740 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 402881008741 putative active site [active] 402881008742 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 402881008743 DHH family; Region: DHH; pfam01368 402881008744 DHHA1 domain; Region: DHHA1; pfam02272 402881008745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 402881008746 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 402881008747 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 402881008748 dimer interface [polypeptide binding]; other site 402881008749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881008750 active site 402881008751 metal binding site [ion binding]; metal-binding site 402881008752 glutathione binding site [chemical binding]; other site 402881008753 NAD-dependent deacetylase; Provisional; Region: PRK00481 402881008754 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 402881008755 NAD+ binding site [chemical binding]; other site 402881008756 substrate binding site [chemical binding]; other site 402881008757 Zn binding site [ion binding]; other site 402881008758 haloalcohol dehalogenase, classical (c) SDRs; Region: haloalcohol_DH_SDR_c-like; cd05361 402881008759 halogen binding site; other site 402881008760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 402881008761 homotetramer interface [polypeptide binding]; other site 402881008762 homodimer interface [polypeptide binding]; other site 402881008763 active site 402881008764 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 402881008765 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 402881008766 active site 402881008767 catalytic site [active] 402881008768 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 402881008769 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 402881008770 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 402881008771 putative MPT binding site; other site 402881008772 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 402881008773 Ligand binding site; other site 402881008774 metal-binding site 402881008775 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 402881008776 XdhC Rossmann domain; Region: XdhC_C; pfam13478 402881008777 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 402881008778 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 402881008779 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 402881008780 metal ion-dependent adhesion site (MIDAS); other site 402881008781 MoxR-like ATPases [General function prediction only]; Region: COG0714 402881008782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881008783 Walker A motif; other site 402881008784 ATP binding site [chemical binding]; other site 402881008785 Walker B motif; other site 402881008786 arginine finger; other site 402881008787 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 402881008788 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 402881008789 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 402881008790 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 402881008791 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 402881008792 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 402881008793 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 402881008794 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 402881008795 putative hydrophobic ligand binding site [chemical binding]; other site 402881008796 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 402881008797 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 402881008798 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 402881008799 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 402881008800 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 402881008801 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 402881008802 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 402881008803 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 402881008804 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 402881008805 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 402881008806 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 402881008807 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 402881008808 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 402881008809 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 402881008810 DNA-binding site [nucleotide binding]; DNA binding site 402881008811 RNA-binding motif; other site 402881008812 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 402881008813 DNA-binding site [nucleotide binding]; DNA binding site 402881008814 RNA-binding motif; other site 402881008815 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881008816 CoenzymeA binding site [chemical binding]; other site 402881008817 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 402881008818 subunit interaction site [polypeptide binding]; other site 402881008819 PHB binding site; other site 402881008820 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 402881008821 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 402881008822 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 402881008823 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 402881008824 active site 402881008825 DNA binding site [nucleotide binding] 402881008826 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 402881008827 DNA binding site [nucleotide binding] 402881008828 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 402881008829 nucleotide binding site [chemical binding]; other site 402881008830 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 402881008831 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 402881008832 putative homodimer interface [polypeptide binding]; other site 402881008833 putative DNA binding site [nucleotide binding]; other site 402881008834 BON domain; Region: BON; pfam04972 402881008835 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881008836 Sel1-like repeats; Region: SEL1; smart00671 402881008837 Sel1-like repeats; Region: SEL1; smart00671 402881008838 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 402881008839 FAD binding domain; Region: FAD_binding_4; pfam01565 402881008840 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 402881008841 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881008842 carboxyltransferase (CT) interaction site; other site 402881008843 biotinylation site [posttranslational modification]; other site 402881008844 cystathionine beta-lyase; Provisional; Region: PRK09028 402881008845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 402881008846 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881008847 catalytic residue [active] 402881008848 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 402881008849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 402881008850 substrate binding pocket [chemical binding]; other site 402881008851 membrane-bound complex binding site; other site 402881008852 hinge residues; other site 402881008853 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 402881008854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881008855 conserved gate region; other site 402881008856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881008857 putative PBP binding loops; other site 402881008858 dimer interface [polypeptide binding]; other site 402881008859 ABC-ATPase subunit interface; other site 402881008860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 402881008861 dimer interface [polypeptide binding]; other site 402881008862 conserved gate region; other site 402881008863 putative PBP binding loops; other site 402881008864 ABC-ATPase subunit interface; other site 402881008865 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 402881008866 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 402881008867 Walker A/P-loop; other site 402881008868 ATP binding site [chemical binding]; other site 402881008869 Q-loop/lid; other site 402881008870 ABC transporter signature motif; other site 402881008871 Walker B; other site 402881008872 D-loop; other site 402881008873 H-loop/switch region; other site 402881008874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881008875 Coenzyme A binding pocket [chemical binding]; other site 402881008876 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 402881008877 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 402881008878 active site residue [active] 402881008879 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 402881008880 active site residue [active] 402881008881 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 402881008882 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 402881008883 dimer interface [polypeptide binding]; other site 402881008884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881008885 catalytic residue [active] 402881008886 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 402881008887 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 402881008888 dimer interface [polypeptide binding]; other site 402881008889 ADP-ribose binding site [chemical binding]; other site 402881008890 active site 402881008891 nudix motif; other site 402881008892 metal binding site [ion binding]; metal-binding site 402881008893 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 402881008894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881008895 S-adenosylmethionine binding site [chemical binding]; other site 402881008896 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 402881008897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881008898 ATP binding site [chemical binding]; other site 402881008899 putative Mg++ binding site [ion binding]; other site 402881008900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881008901 nucleotide binding region [chemical binding]; other site 402881008902 ATP-binding site [chemical binding]; other site 402881008903 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 402881008904 HRDC domain; Region: HRDC; pfam00570 402881008905 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 402881008906 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 402881008907 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 402881008908 putative active site [active] 402881008909 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 402881008910 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 402881008911 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 402881008912 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 402881008913 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 402881008914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 402881008915 Cupin-like domain; Region: Cupin_8; pfam13621 402881008916 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 402881008917 Chain length determinant protein; Region: Wzz; pfam02706 402881008918 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 402881008919 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 402881008920 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 402881008921 SLBB domain; Region: SLBB; pfam10531 402881008922 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 402881008923 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 402881008924 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 402881008925 O-Antigen ligase; Region: Wzy_C; cl04850 402881008926 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 402881008927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881008928 S-adenosylmethionine binding site [chemical binding]; other site 402881008929 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 402881008930 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 402881008931 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 402881008932 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 402881008933 HIGH motif; other site 402881008934 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 402881008935 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 402881008936 active site 402881008937 KMSKS motif; other site 402881008938 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 402881008939 tRNA binding surface [nucleotide binding]; other site 402881008940 anticodon binding site; other site 402881008941 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 402881008942 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 402881008943 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 402881008944 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 402881008945 NAD binding site [chemical binding]; other site 402881008946 catalytic Zn binding site [ion binding]; other site 402881008947 substrate binding site [chemical binding]; other site 402881008948 structural Zn binding site [ion binding]; other site 402881008949 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 402881008950 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881008951 Sel1-like repeats; Region: SEL1; smart00671 402881008952 EthD domain; Region: EthD; pfam07110 402881008953 Uncharacterized conserved protein [Function unknown]; Region: COG5476 402881008954 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 402881008955 MlrC C-terminus; Region: MlrC_C; pfam07171 402881008956 Uncharacterized conserved protein [Function unknown]; Region: COG1359 402881008957 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 402881008958 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 402881008959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 402881008960 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 402881008961 Uncharacterized conserved protein [Function unknown]; Region: COG3791 402881008962 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 402881008963 putative catalytic site [active] 402881008964 putative phosphate binding site [ion binding]; other site 402881008965 active site 402881008966 metal binding site A [ion binding]; metal-binding site 402881008967 DNA binding site [nucleotide binding] 402881008968 putative AP binding site [nucleotide binding]; other site 402881008969 putative metal binding site B [ion binding]; other site 402881008970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881008971 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 402881008972 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 402881008973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 402881008974 Zn2+ binding site [ion binding]; other site 402881008975 Mg2+ binding site [ion binding]; other site 402881008976 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 402881008977 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 402881008978 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 402881008979 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 402881008980 active site 402881008981 HIGH motif; other site 402881008982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 402881008983 KMSK motif region; other site 402881008984 tRNA binding surface [nucleotide binding]; other site 402881008985 DALR anticodon binding domain; Region: DALR_1; smart00836 402881008986 anticodon binding site; other site 402881008987 Sporulation related domain; Region: SPOR; pfam05036 402881008988 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 402881008989 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 402881008990 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 402881008991 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 402881008992 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 402881008993 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 402881008994 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 402881008995 seryl-tRNA synthetase; Provisional; Region: PRK05431 402881008996 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 402881008997 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 402881008998 dimer interface [polypeptide binding]; other site 402881008999 active site 402881009000 motif 1; other site 402881009001 motif 2; other site 402881009002 motif 3; other site 402881009003 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 402881009004 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 402881009005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881009006 S-adenosylmethionine binding site [chemical binding]; other site 402881009007 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 402881009008 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 402881009009 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 402881009010 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881009011 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 402881009012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881009013 Walker A motif; other site 402881009014 ATP binding site [chemical binding]; other site 402881009015 Walker B motif; other site 402881009016 Preprotein translocase subunit; Region: YajC; pfam02699 402881009017 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 402881009018 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 402881009019 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 402881009020 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 402881009021 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 402881009022 Protein export membrane protein; Region: SecD_SecF; pfam02355 402881009023 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 402881009024 Protein of unknown function (DUF989); Region: DUF989; pfam06181 402881009025 Protein of unknown function (DUF989); Region: DUF989; pfam06181 402881009026 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 402881009027 substrate binding pocket [chemical binding]; other site 402881009028 aspartate-rich region 2; other site 402881009029 substrate-Mg2+ binding site; other site 402881009030 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 402881009031 Glucose inhibited division protein A; Region: GIDA; pfam01134 402881009032 amidase; Provisional; Region: PRK07869 402881009033 Amidase; Region: Amidase; pfam01425 402881009034 amidase; Provisional; Region: PRK07869 402881009035 Amidase; Region: Amidase; cl11426 402881009036 PhoD-like phosphatase; Region: PhoD; pfam09423 402881009037 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 402881009038 putative active site [active] 402881009039 putative metal binding site [ion binding]; other site 402881009040 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 402881009041 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 402881009042 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 402881009043 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 402881009044 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 402881009045 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 402881009046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 402881009047 dimer interface [polypeptide binding]; other site 402881009048 ssDNA binding site [nucleotide binding]; other site 402881009049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 402881009050 DNA gyrase subunit A; Validated; Region: PRK05560 402881009051 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 402881009052 CAP-like domain; other site 402881009053 active site 402881009054 primary dimer interface [polypeptide binding]; other site 402881009055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 402881009056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 402881009057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 402881009058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 402881009059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 402881009060 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 402881009061 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 402881009062 active site 402881009063 (T/H)XGH motif; other site 402881009064 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 402881009065 active site 402881009066 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 402881009067 active site 402881009068 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 402881009069 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 402881009070 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 402881009071 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 402881009072 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 402881009073 Trp docking motif [polypeptide binding]; other site 402881009074 PQQ-like domain; Region: PQQ_2; pfam13360 402881009075 putative active site [active] 402881009076 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 402881009077 Uncharacterized conserved protein [Function unknown]; Region: COG3791 402881009078 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 402881009079 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 402881009080 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 402881009081 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 402881009082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881009083 non-specific DNA binding site [nucleotide binding]; other site 402881009084 salt bridge; other site 402881009085 sequence-specific DNA binding site [nucleotide binding]; other site 402881009086 Bacterial SH3 domain; Region: SH3_3; pfam08239 402881009087 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 402881009088 active site clefts [active] 402881009089 zinc binding site [ion binding]; other site 402881009090 dimer interface [polypeptide binding]; other site 402881009091 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 402881009092 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 402881009093 Active Sites [active] 402881009094 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 402881009095 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 402881009096 CysD dimerization site [polypeptide binding]; other site 402881009097 G1 box; other site 402881009098 putative GEF interaction site [polypeptide binding]; other site 402881009099 GTP/Mg2+ binding site [chemical binding]; other site 402881009100 Switch I region; other site 402881009101 G2 box; other site 402881009102 G3 box; other site 402881009103 Switch II region; other site 402881009104 G4 box; other site 402881009105 G5 box; other site 402881009106 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 402881009107 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 402881009108 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 402881009109 ligand-binding site [chemical binding]; other site 402881009110 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 402881009111 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 402881009112 NAD binding site [chemical binding]; other site 402881009113 homodimer interface [polypeptide binding]; other site 402881009114 active site 402881009115 substrate binding site [chemical binding]; other site 402881009116 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 402881009117 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 402881009118 Substrate binding site; other site 402881009119 Mg++ binding site; other site 402881009120 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 402881009121 active site 402881009122 substrate binding site [chemical binding]; other site 402881009123 CoA binding site [chemical binding]; other site 402881009124 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 402881009125 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 402881009126 glutaminase active site [active] 402881009127 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 402881009128 dimer interface [polypeptide binding]; other site 402881009129 active site 402881009130 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 402881009131 dimer interface [polypeptide binding]; other site 402881009132 active site 402881009133 TPR repeat; Region: TPR_11; pfam13414 402881009134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881009135 binding surface 402881009136 TPR motif; other site 402881009137 TPR repeat; Region: TPR_11; pfam13414 402881009138 TPR repeat; Region: TPR_11; pfam13414 402881009139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881009140 binding surface 402881009141 TPR motif; other site 402881009142 Sporulation related domain; Region: SPOR; pfam05036 402881009143 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 402881009144 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 402881009145 dimer interface [polypeptide binding]; other site 402881009146 active site 402881009147 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 402881009148 DUF35 OB-fold domain; Region: DUF35; pfam01796 402881009149 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 402881009150 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 402881009151 active site 402881009152 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 402881009153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881009154 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 402881009155 Phosphotransferase enzyme family; Region: APH; pfam01636 402881009156 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 402881009157 putative active site [active] 402881009158 putative substrate binding site [chemical binding]; other site 402881009159 ATP binding site [chemical binding]; other site 402881009160 Uncharacterized conserved protein [Function unknown]; Region: COG2928 402881009161 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 402881009162 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 402881009163 generic binding surface II; other site 402881009164 ssDNA binding site; other site 402881009165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881009166 ATP binding site [chemical binding]; other site 402881009167 putative Mg++ binding site [ion binding]; other site 402881009168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881009169 nucleotide binding region [chemical binding]; other site 402881009170 ATP-binding site [chemical binding]; other site 402881009171 Uncharacterized conserved protein [Function unknown]; Region: COG2938 402881009172 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 402881009173 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 402881009174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881009175 ATP binding site [chemical binding]; other site 402881009176 putative Mg++ binding site [ion binding]; other site 402881009177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881009178 nucleotide binding region [chemical binding]; other site 402881009179 ATP-binding site [chemical binding]; other site 402881009180 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 402881009181 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 402881009182 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 402881009183 catalytic residues [active] 402881009184 short chain dehydrogenase; Provisional; Region: PRK06949 402881009185 classical (c) SDRs; Region: SDR_c; cd05233 402881009186 NAD(P) binding site [chemical binding]; other site 402881009187 active site 402881009188 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 402881009189 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 402881009190 Na binding site [ion binding]; other site 402881009191 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 402881009192 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 402881009193 acyl-activating enzyme (AAE) consensus motif; other site 402881009194 AMP binding site [chemical binding]; other site 402881009195 active site 402881009196 CoA binding site [chemical binding]; other site 402881009197 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 402881009198 CoA-transferase family III; Region: CoA_transf_3; pfam02515 402881009199 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 402881009200 catalytic core [active] 402881009201 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 402881009202 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 402881009203 acyl-activating enzyme (AAE) consensus motif; other site 402881009204 active site 402881009205 AMP binding site [chemical binding]; other site 402881009206 substrate binding site [chemical binding]; other site 402881009207 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 402881009208 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 402881009209 FMN binding site [chemical binding]; other site 402881009210 substrate binding site [chemical binding]; other site 402881009211 putative catalytic residue [active] 402881009212 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 402881009213 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 402881009214 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 402881009215 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 402881009216 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 402881009217 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 402881009218 trimer interface [polypeptide binding]; other site 402881009219 active site 402881009220 substrate binding site [chemical binding]; other site 402881009221 CoA binding site [chemical binding]; other site 402881009222 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 402881009223 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 402881009224 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 402881009225 putative active site [active] 402881009226 putative FMN binding site [chemical binding]; other site 402881009227 putative substrate binding site [chemical binding]; other site 402881009228 putative catalytic residue [active] 402881009229 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 402881009230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881009231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881009232 putative substrate translocation pore; other site 402881009233 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 402881009234 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 402881009235 trimer interface [polypeptide binding]; other site 402881009236 putative metal binding site [ion binding]; other site 402881009237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881009238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881009239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881009240 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 402881009241 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 402881009242 putative C-terminal domain interface [polypeptide binding]; other site 402881009243 putative GSH binding site (G-site) [chemical binding]; other site 402881009244 putative dimer interface [polypeptide binding]; other site 402881009245 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 402881009246 N-terminal domain interface [polypeptide binding]; other site 402881009247 dimer interface [polypeptide binding]; other site 402881009248 substrate binding pocket (H-site) [chemical binding]; other site 402881009249 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881009250 CoenzymeA binding site [chemical binding]; other site 402881009251 subunit interaction site [polypeptide binding]; other site 402881009252 PHB binding site; other site 402881009253 Protein of unknown function DUF72; Region: DUF72; pfam01904 402881009254 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 402881009255 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 402881009256 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 402881009257 Sporulation related domain; Region: SPOR; pfam05036 402881009258 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 402881009259 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 402881009260 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 402881009261 thymidylate kinase; Validated; Region: tmk; PRK00698 402881009262 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 402881009263 TMP-binding site; other site 402881009264 ATP-binding site [chemical binding]; other site 402881009265 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 402881009266 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881009267 DNA polymerase III subunit delta'; Validated; Region: PRK07471 402881009268 DNA polymerase III subunit delta'; Validated; Region: PRK08485 402881009269 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 402881009270 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 402881009271 active site 402881009272 HIGH motif; other site 402881009273 KMSKS motif; other site 402881009274 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 402881009275 tRNA binding surface [nucleotide binding]; other site 402881009276 anticodon binding site; other site 402881009277 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 402881009278 active site 402881009279 putative hydrolase; Provisional; Region: PRK02113 402881009280 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 402881009281 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 402881009282 MFS/sugar transport protein; Region: MFS_2; pfam13347 402881009283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881009284 putative substrate translocation pore; other site 402881009285 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 402881009286 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 402881009287 homodimer interface [polypeptide binding]; other site 402881009288 metal binding site [ion binding]; metal-binding site 402881009289 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 402881009290 homodimer interface [polypeptide binding]; other site 402881009291 active site 402881009292 putative chemical substrate binding site [chemical binding]; other site 402881009293 metal binding site [ion binding]; metal-binding site 402881009294 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 402881009295 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 402881009296 active site 402881009297 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 402881009298 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 402881009299 HflX GTPase family; Region: HflX; cd01878 402881009300 G1 box; other site 402881009301 GTP/Mg2+ binding site [chemical binding]; other site 402881009302 Switch I region; other site 402881009303 G2 box; other site 402881009304 G3 box; other site 402881009305 Switch II region; other site 402881009306 G4 box; other site 402881009307 G5 box; other site 402881009308 bacterial Hfq-like; Region: Hfq; cd01716 402881009309 hexamer interface [polypeptide binding]; other site 402881009310 Sm1 motif; other site 402881009311 RNA binding site [nucleotide binding]; other site 402881009312 Sm2 motif; other site 402881009313 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 402881009314 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 402881009315 homodimer interface [polypeptide binding]; other site 402881009316 substrate-cofactor binding pocket; other site 402881009317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881009318 catalytic residue [active] 402881009319 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 402881009320 TrkA-N domain; Region: TrkA_N; pfam02254 402881009321 TrkA-C domain; Region: TrkA_C; pfam02080 402881009322 TrkA-N domain; Region: TrkA_N; pfam02254 402881009323 TrkA-C domain; Region: TrkA_C; pfam02080 402881009324 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 402881009325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881009326 active site 402881009327 phosphorylation site [posttranslational modification] 402881009328 intermolecular recognition site; other site 402881009329 dimerization interface [polypeptide binding]; other site 402881009330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881009331 Walker A motif; other site 402881009332 ATP binding site [chemical binding]; other site 402881009333 Walker B motif; other site 402881009334 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 402881009335 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 402881009336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 402881009337 dimerization interface [polypeptide binding]; other site 402881009338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881009339 putative active site [active] 402881009340 heme pocket [chemical binding]; other site 402881009341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881009342 dimer interface [polypeptide binding]; other site 402881009343 phosphorylation site [posttranslational modification] 402881009344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881009345 ATP binding site [chemical binding]; other site 402881009346 G-X-G motif; other site 402881009347 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 402881009348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881009349 active site 402881009350 phosphorylation site [posttranslational modification] 402881009351 intermolecular recognition site; other site 402881009352 dimerization interface [polypeptide binding]; other site 402881009353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881009354 Walker A motif; other site 402881009355 ATP binding site [chemical binding]; other site 402881009356 Walker B motif; other site 402881009357 arginine finger; other site 402881009358 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 402881009359 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 402881009360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 402881009361 putative active site [active] 402881009362 heme pocket [chemical binding]; other site 402881009363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881009364 dimer interface [polypeptide binding]; other site 402881009365 phosphorylation site [posttranslational modification] 402881009366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881009367 ATP binding site [chemical binding]; other site 402881009368 Mg2+ binding site [ion binding]; other site 402881009369 G-X-G motif; other site 402881009370 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 402881009371 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 402881009372 FMN binding site [chemical binding]; other site 402881009373 active site 402881009374 catalytic residues [active] 402881009375 substrate binding site [chemical binding]; other site 402881009376 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 402881009377 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 402881009378 substrate binding site; other site 402881009379 dimer interface; other site 402881009380 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 402881009381 homotrimer interaction site [polypeptide binding]; other site 402881009382 zinc binding site [ion binding]; other site 402881009383 CDP-binding sites; other site 402881009384 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 402881009385 tetramer interfaces [polypeptide binding]; other site 402881009386 binuclear metal-binding site [ion binding]; other site 402881009387 Competence-damaged protein; Region: CinA; pfam02464 402881009388 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 402881009389 putative coenzyme Q binding site [chemical binding]; other site 402881009390 lipoyl synthase; Provisional; Region: PRK05481 402881009391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881009392 FeS/SAM binding site; other site 402881009393 Sulfatase; Region: Sulfatase; cl17466 402881009394 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881009395 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 402881009396 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 402881009397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 402881009398 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 402881009399 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 402881009400 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 402881009401 E3 interaction surface; other site 402881009402 lipoyl attachment site [posttranslational modification]; other site 402881009403 e3 binding domain; Region: E3_binding; pfam02817 402881009404 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 402881009405 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 402881009406 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 402881009407 E3 interaction surface; other site 402881009408 lipoyl attachment site [posttranslational modification]; other site 402881009409 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 402881009410 alpha subunit interface [polypeptide binding]; other site 402881009411 TPP binding site [chemical binding]; other site 402881009412 heterodimer interface [polypeptide binding]; other site 402881009413 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 402881009414 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 402881009415 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 402881009416 tetramer interface [polypeptide binding]; other site 402881009417 TPP-binding site [chemical binding]; other site 402881009418 heterodimer interface [polypeptide binding]; other site 402881009419 phosphorylation loop region [posttranslational modification] 402881009420 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 402881009421 Septum formation initiator; Region: DivIC; pfam04977 402881009422 enolase; Provisional; Region: eno; PRK00077 402881009423 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 402881009424 dimer interface [polypeptide binding]; other site 402881009425 metal binding site [ion binding]; metal-binding site 402881009426 substrate binding pocket [chemical binding]; other site 402881009427 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 402881009428 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 402881009429 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 402881009430 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 402881009431 N-terminal plug; other site 402881009432 ligand-binding site [chemical binding]; other site 402881009433 Predicted transcriptional regulators [Transcription]; Region: COG1695 402881009434 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 402881009435 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 402881009436 Ligand Binding Site [chemical binding]; other site 402881009437 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 402881009438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881009439 FeS/SAM binding site; other site 402881009440 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 402881009441 active site 402881009442 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 402881009443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881009444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881009445 dimer interface [polypeptide binding]; other site 402881009446 phosphorylation site [posttranslational modification] 402881009447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881009448 ATP binding site [chemical binding]; other site 402881009449 Mg2+ binding site [ion binding]; other site 402881009450 G-X-G motif; other site 402881009451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881009452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881009453 Mg2+ binding site [ion binding]; other site 402881009454 G-X-G motif; other site 402881009455 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 402881009456 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 402881009457 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 402881009458 CTP synthetase; Validated; Region: pyrG; PRK05380 402881009459 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 402881009460 Catalytic site [active] 402881009461 active site 402881009462 UTP binding site [chemical binding]; other site 402881009463 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 402881009464 active site 402881009465 putative oxyanion hole; other site 402881009466 catalytic triad [active] 402881009467 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 402881009468 DNA-binding site [nucleotide binding]; DNA binding site 402881009469 RNA-binding motif; other site 402881009470 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 402881009471 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 402881009472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 402881009473 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 402881009474 DNA binding residues [nucleotide binding] 402881009475 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 402881009476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 402881009477 triosephosphate isomerase; Provisional; Region: PRK14565 402881009478 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 402881009479 substrate binding site [chemical binding]; other site 402881009480 dimer interface [polypeptide binding]; other site 402881009481 catalytic triad [active] 402881009482 SurA N-terminal domain; Region: SurA_N_3; cl07813 402881009483 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 402881009484 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 402881009485 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 402881009486 anthranilate synthase component I; Provisional; Region: PRK13573 402881009487 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 402881009488 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 402881009489 hypothetical protein; Provisional; Region: PRK06185 402881009490 hypothetical protein; Provisional; Region: PRK07236 402881009491 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 402881009492 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 402881009493 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 402881009494 glutamine binding [chemical binding]; other site 402881009495 catalytic triad [active] 402881009496 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 402881009497 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 402881009498 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 402881009499 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 402881009500 active site 402881009501 ribulose/triose binding site [chemical binding]; other site 402881009502 phosphate binding site [ion binding]; other site 402881009503 substrate (anthranilate) binding pocket [chemical binding]; other site 402881009504 product (indole) binding pocket [chemical binding]; other site 402881009505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881009506 Coenzyme A binding pocket [chemical binding]; other site 402881009507 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 402881009508 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 402881009509 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 402881009510 trimer interface [polypeptide binding]; other site 402881009511 dimer interface [polypeptide binding]; other site 402881009512 putative active site [active] 402881009513 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 402881009514 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 402881009515 dimer interface [polypeptide binding]; other site 402881009516 putative functional site; other site 402881009517 putative MPT binding site; other site 402881009518 LexA repressor; Validated; Region: PRK00215 402881009519 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 402881009520 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 402881009521 Catalytic site [active] 402881009522 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 402881009523 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 402881009524 Competence protein; Region: Competence; pfam03772 402881009525 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 402881009526 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 402881009527 HIGH motif; other site 402881009528 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 402881009529 active site 402881009530 KMSKS motif; other site 402881009531 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 402881009532 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 402881009533 dimer interface [polypeptide binding]; other site 402881009534 active site 402881009535 citrylCoA binding site [chemical binding]; other site 402881009536 NADH binding [chemical binding]; other site 402881009537 cationic pore residues; other site 402881009538 oxalacetate/citrate binding site [chemical binding]; other site 402881009539 coenzyme A binding site [chemical binding]; other site 402881009540 catalytic triad [active] 402881009541 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 402881009542 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 402881009543 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 402881009544 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 402881009545 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 402881009546 active site 402881009547 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 402881009548 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 402881009549 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 402881009550 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 402881009551 trimer interface [polypeptide binding]; other site 402881009552 active site 402881009553 UDP-GlcNAc binding site [chemical binding]; other site 402881009554 lipid binding site [chemical binding]; lipid-binding site 402881009555 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 402881009556 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 402881009557 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 402881009558 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 402881009559 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 402881009560 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 402881009561 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 402881009562 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 402881009563 Surface antigen; Region: Bac_surface_Ag; pfam01103 402881009564 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 402881009565 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 402881009566 active site 402881009567 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 402881009568 protein binding site [polypeptide binding]; other site 402881009569 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 402881009570 putative substrate binding region [chemical binding]; other site 402881009571 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 402881009572 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 402881009573 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 402881009574 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 402881009575 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 402881009576 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 402881009577 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 402881009578 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 402881009579 catalytic residue [active] 402881009580 putative FPP diphosphate binding site; other site 402881009581 putative FPP binding hydrophobic cleft; other site 402881009582 dimer interface [polypeptide binding]; other site 402881009583 putative IPP diphosphate binding site; other site 402881009584 ribosome recycling factor; Reviewed; Region: frr; PRK00083 402881009585 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 402881009586 hinge region; other site 402881009587 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 402881009588 putative nucleotide binding site [chemical binding]; other site 402881009589 uridine monophosphate binding site [chemical binding]; other site 402881009590 homohexameric interface [polypeptide binding]; other site 402881009591 elongation factor Ts; Provisional; Region: tsf; PRK09377 402881009592 UBA/TS-N domain; Region: UBA; pfam00627 402881009593 Elongation factor TS; Region: EF_TS; pfam00889 402881009594 Elongation factor TS; Region: EF_TS; pfam00889 402881009595 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 402881009596 rRNA interaction site [nucleotide binding]; other site 402881009597 S8 interaction site; other site 402881009598 putative laminin-1 binding site; other site 402881009599 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 402881009600 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 402881009601 putative active site [active] 402881009602 putative PHP Thumb interface [polypeptide binding]; other site 402881009603 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 402881009604 generic binding surface II; other site 402881009605 generic binding surface I; other site 402881009606 Protein of unknown function DUF262; Region: DUF262; pfam03235 402881009607 RibD C-terminal domain; Region: RibD_C; cl17279 402881009608 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 402881009609 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 402881009610 putative hydrophobic ligand binding site [chemical binding]; other site 402881009611 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 402881009612 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 402881009613 Walker A/P-loop; other site 402881009614 ATP binding site [chemical binding]; other site 402881009615 Q-loop/lid; other site 402881009616 ABC transporter signature motif; other site 402881009617 Walker B; other site 402881009618 D-loop; other site 402881009619 H-loop/switch region; other site 402881009620 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 402881009621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 402881009622 FtsX-like permease family; Region: FtsX; pfam02687 402881009623 prolyl-tRNA synthetase; Provisional; Region: PRK12325 402881009624 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 402881009625 dimer interface [polypeptide binding]; other site 402881009626 motif 1; other site 402881009627 active site 402881009628 motif 2; other site 402881009629 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 402881009630 active site 402881009631 motif 3; other site 402881009632 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 402881009633 anticodon binding site; other site 402881009634 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 402881009635 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 402881009636 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 402881009637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881009638 dimer interface [polypeptide binding]; other site 402881009639 substrate binding site [chemical binding]; other site 402881009640 metal binding site [ion binding]; metal-binding site 402881009641 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 402881009642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881009643 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 402881009644 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 402881009645 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 402881009646 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 402881009647 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 402881009648 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 402881009649 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 402881009650 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 402881009651 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 402881009652 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 402881009653 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 402881009654 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 402881009655 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 402881009656 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 402881009657 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 402881009658 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 402881009659 4Fe-4S binding domain; Region: Fer4; cl02805 402881009660 4Fe-4S binding domain; Region: Fer4; pfam00037 402881009661 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 402881009662 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 402881009663 NADH dehydrogenase subunit G; Validated; Region: PRK09130 402881009664 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 402881009665 catalytic loop [active] 402881009666 iron binding site [ion binding]; other site 402881009667 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 402881009668 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 402881009669 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 402881009670 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 402881009671 SLBB domain; Region: SLBB; pfam10531 402881009672 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 402881009673 NADH dehydrogenase subunit E; Validated; Region: PRK07539 402881009674 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 402881009675 putative dimer interface [polypeptide binding]; other site 402881009676 [2Fe-2S] cluster binding site [ion binding]; other site 402881009677 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 402881009678 NADH dehydrogenase subunit D; Validated; Region: PRK06075 402881009679 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 402881009680 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 402881009681 NADH dehydrogenase subunit B; Validated; Region: PRK06411 402881009682 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 402881009683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 402881009684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 402881009685 putative substrate translocation pore; other site 402881009686 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 402881009687 IHF dimer interface [polypeptide binding]; other site 402881009688 IHF - DNA interface [nucleotide binding]; other site 402881009689 Found in ATP-dependent protease La (LON); Region: LON; smart00464 402881009690 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 402881009691 Found in ATP-dependent protease La (LON); Region: LON; smart00464 402881009692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881009693 Walker A motif; other site 402881009694 ATP binding site [chemical binding]; other site 402881009695 Walker B motif; other site 402881009696 arginine finger; other site 402881009697 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 402881009698 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 402881009699 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 402881009700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881009701 Walker A motif; other site 402881009702 ATP binding site [chemical binding]; other site 402881009703 Walker B motif; other site 402881009704 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 402881009705 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 402881009706 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 402881009707 oligomer interface [polypeptide binding]; other site 402881009708 active site residues [active] 402881009709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 402881009710 Coenzyme A binding pocket [chemical binding]; other site 402881009711 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 402881009712 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 402881009713 dimer interface [polypeptide binding]; other site 402881009714 active site 402881009715 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 402881009716 catalytic residues [active] 402881009717 substrate binding site [chemical binding]; other site 402881009718 trigger factor; Provisional; Region: tig; PRK01490 402881009719 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 402881009720 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 402881009721 Uncharacterized conserved protein [Function unknown]; Region: COG0062 402881009722 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 402881009723 putative substrate binding site [chemical binding]; other site 402881009724 putative ATP binding site [chemical binding]; other site 402881009725 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 402881009726 catalytic core [active] 402881009727 Predicted membrane protein [Function unknown]; Region: COG3671 402881009728 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 402881009729 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 402881009730 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 402881009731 active site 402881009732 Predicted esterase [General function prediction only]; Region: COG0400 402881009733 putative hydrolase; Provisional; Region: PRK11460 402881009734 hypothetical protein; Provisional; Region: PRK08912 402881009735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 402881009736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881009737 homodimer interface [polypeptide binding]; other site 402881009738 catalytic residue [active] 402881009739 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 402881009740 Nitrogen regulatory protein P-II; Region: P-II; smart00938 402881009741 glutamine synthetase; Provisional; Region: glnA; PRK09469 402881009742 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 402881009743 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 402881009744 Predicted ATPase [General function prediction only]; Region: COG3911 402881009745 AAA domain; Region: AAA_28; pfam13521 402881009746 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 402881009747 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 402881009748 transmembrane helices; other site 402881009749 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 402881009750 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 402881009751 putative active site [active] 402881009752 putative FMN binding site [chemical binding]; other site 402881009753 putative substrate binding site [chemical binding]; other site 402881009754 putative catalytic residue [active] 402881009755 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 402881009756 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 402881009757 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 402881009758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881009759 Mg2+ binding site [ion binding]; other site 402881009760 G-X-G motif; other site 402881009761 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 402881009762 anchoring element; other site 402881009763 dimer interface [polypeptide binding]; other site 402881009764 ATP binding site [chemical binding]; other site 402881009765 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 402881009766 active site 402881009767 metal binding site [ion binding]; metal-binding site 402881009768 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 402881009769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881009770 dimer interface [polypeptide binding]; other site 402881009771 phosphorylation site [posttranslational modification] 402881009772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881009773 ATP binding site [chemical binding]; other site 402881009774 Mg2+ binding site [ion binding]; other site 402881009775 G-X-G motif; other site 402881009776 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 402881009777 DEAD-like helicases superfamily; Region: DEXDc; smart00487 402881009778 ATP binding site [chemical binding]; other site 402881009779 Mg++ binding site [ion binding]; other site 402881009780 motif III; other site 402881009781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881009782 nucleotide binding region [chemical binding]; other site 402881009783 ATP-binding site [chemical binding]; other site 402881009784 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 402881009785 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 402881009786 NAD(P) binding site [chemical binding]; other site 402881009787 catalytic residues [active] 402881009788 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 402881009789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 402881009790 metal binding site [ion binding]; metal-binding site 402881009791 active site 402881009792 I-site; other site 402881009793 enoyl-CoA hydratase; Provisional; Region: PRK08140 402881009794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881009795 substrate binding site [chemical binding]; other site 402881009796 oxyanion hole (OAH) forming residues; other site 402881009797 trimer interface [polypeptide binding]; other site 402881009798 enoyl-CoA hydratase; Provisional; Region: PRK05981 402881009799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881009800 substrate binding site [chemical binding]; other site 402881009801 oxyanion hole (OAH) forming residues; other site 402881009802 trimer interface [polypeptide binding]; other site 402881009803 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 402881009804 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 402881009805 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 402881009806 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 402881009807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881009808 catalytic residue [active] 402881009809 FeS assembly protein SufD; Region: sufD; TIGR01981 402881009810 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 402881009811 FeS assembly ATPase SufC; Region: sufC; TIGR01978 402881009812 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 402881009813 Walker A/P-loop; other site 402881009814 ATP binding site [chemical binding]; other site 402881009815 Q-loop/lid; other site 402881009816 ABC transporter signature motif; other site 402881009817 Walker B; other site 402881009818 D-loop; other site 402881009819 H-loop/switch region; other site 402881009820 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 402881009821 putative ABC transporter; Region: ycf24; CHL00085 402881009822 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 402881009823 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 402881009824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 402881009825 catalytic residue [active] 402881009826 Transcriptional regulator; Region: Rrf2; cl17282 402881009827 Rrf2 family protein; Region: rrf2_super; TIGR00738 402881009828 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 402881009829 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 402881009830 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 402881009831 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 402881009832 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 402881009833 active site 402881009834 HIGH motif; other site 402881009835 dimer interface [polypeptide binding]; other site 402881009836 KMSKS motif; other site 402881009837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 402881009838 RNA binding surface [nucleotide binding]; other site 402881009839 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 402881009840 dinuclear metal binding motif [ion binding]; other site 402881009841 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 402881009842 Protein of unknown function; Region: DUF3971; pfam13116 402881009843 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 402881009844 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 402881009845 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 402881009846 catalytic triad [active] 402881009847 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 402881009848 dinuclear metal binding motif [ion binding]; other site 402881009849 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 402881009850 Peptidase family M23; Region: Peptidase_M23; pfam01551 402881009851 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 402881009852 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 402881009853 Predicted flavoproteins [General function prediction only]; Region: COG2081 402881009854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 402881009855 peptide chain release factor 2; Provisional; Region: PRK07342 402881009856 This domain is found in peptide chain release factors; Region: PCRF; smart00937 402881009857 RF-1 domain; Region: RF-1; pfam00472 402881009858 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 402881009859 Transglycosylase; Region: Transgly; pfam00912 402881009860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 402881009861 AMIN domain; Region: AMIN; pfam11741 402881009862 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 402881009863 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 402881009864 active site 402881009865 metal binding site [ion binding]; metal-binding site 402881009866 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 402881009867 homodimer interface [polypeptide binding]; other site 402881009868 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 402881009869 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 402881009870 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 402881009871 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 402881009872 Peptidase family M48; Region: Peptidase_M48; cl12018 402881009873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881009874 binding surface 402881009875 TPR motif; other site 402881009876 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 402881009877 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 402881009878 catalytic residues [active] 402881009879 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 402881009880 Fatty acid desaturase; Region: FA_desaturase; pfam00487 402881009881 putative di-iron ligands [ion binding]; other site 402881009882 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 402881009883 AMP binding site [chemical binding]; other site 402881009884 metal binding site [ion binding]; metal-binding site 402881009885 active site 402881009886 Predicted membrane protein [Function unknown]; Region: COG4325 402881009887 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 402881009888 Predicted membrane protein [Function unknown]; Region: COG2323 402881009889 Predicted membrane protein [Function unknown]; Region: COG2323 402881009890 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 402881009891 ThiS interaction site; other site 402881009892 putative active site [active] 402881009893 tetramer interface [polypeptide binding]; other site 402881009894 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 402881009895 thiS-thiF/thiG interaction site; other site 402881009896 Dehydroquinase class II; Region: DHquinase_II; pfam01220 402881009897 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 402881009898 trimer interface [polypeptide binding]; other site 402881009899 active site 402881009900 dimer interface [polypeptide binding]; other site 402881009901 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 402881009902 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881009903 carboxyltransferase (CT) interaction site; other site 402881009904 biotinylation site [posttranslational modification]; other site 402881009905 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 402881009906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 402881009907 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881009908 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 402881009909 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 402881009910 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 402881009911 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 402881009912 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 402881009913 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 402881009914 mce related protein; Region: MCE; pfam02470 402881009915 NADH dehydrogenase; Validated; Region: PRK08183 402881009916 Response regulator receiver domain; Region: Response_reg; pfam00072 402881009917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881009918 active site 402881009919 phosphorylation site [posttranslational modification] 402881009920 intermolecular recognition site; other site 402881009921 dimerization interface [polypeptide binding]; other site 402881009922 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 402881009923 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 402881009924 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 402881009925 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 402881009926 active site 402881009927 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 402881009928 TSCPD domain; Region: TSCPD; pfam12637 402881009929 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 402881009930 ATP-grasp domain; Region: ATP-grasp_4; cl17255 402881009931 Fasciclin domain; Region: Fasciclin; pfam02469 402881009932 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 402881009933 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 402881009934 dimer interface [polypeptide binding]; other site 402881009935 anticodon binding site; other site 402881009936 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 402881009937 homodimer interface [polypeptide binding]; other site 402881009938 motif 1; other site 402881009939 active site 402881009940 motif 2; other site 402881009941 GAD domain; Region: GAD; pfam02938 402881009942 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 402881009943 active site 402881009944 motif 3; other site 402881009945 Acyltransferase family; Region: Acyl_transf_3; pfam01757 402881009946 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 402881009947 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 402881009948 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 402881009949 NAD binding site [chemical binding]; other site 402881009950 substrate binding site [chemical binding]; other site 402881009951 homodimer interface [polypeptide binding]; other site 402881009952 active site 402881009953 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 402881009954 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 402881009955 substrate binding site; other site 402881009956 tetramer interface; other site 402881009957 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 402881009958 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 402881009959 Ligand binding site; other site 402881009960 Putative Catalytic site; other site 402881009961 DXD motif; other site 402881009962 Methyltransferase domain; Region: Methyltransf_12; pfam08242 402881009963 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 402881009964 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 402881009965 putative trimer interface [polypeptide binding]; other site 402881009966 putative CoA binding site [chemical binding]; other site 402881009967 WbqC-like protein family; Region: WbqC; pfam08889 402881009968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 402881009969 Protein of unknown function, DUF393; Region: DUF393; pfam04134 402881009970 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 402881009971 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 402881009972 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881009973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881009974 S-adenosylmethionine binding site [chemical binding]; other site 402881009975 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 402881009976 Ligand binding site; other site 402881009977 Putative Catalytic site; other site 402881009978 DXD motif; other site 402881009979 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 402881009980 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 402881009981 inhibitor-cofactor binding pocket; inhibition site 402881009982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881009983 catalytic residue [active] 402881009984 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881009985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881009986 S-adenosylmethionine binding site [chemical binding]; other site 402881009987 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881009988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881009989 S-adenosylmethionine binding site [chemical binding]; other site 402881009990 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 402881009991 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 402881009992 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 402881009993 catalytic site [active] 402881009994 putative active site [active] 402881009995 putative substrate binding site [chemical binding]; other site 402881009996 HRDC domain; Region: HRDC; pfam00570 402881009997 exopolyphosphatase; Region: exo_poly_only; TIGR03706 402881009998 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 402881009999 polyphosphate kinase; Provisional; Region: PRK05443 402881010000 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 402881010001 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 402881010002 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 402881010003 putative domain interface [polypeptide binding]; other site 402881010004 putative active site [active] 402881010005 catalytic site [active] 402881010006 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 402881010007 putative domain interface [polypeptide binding]; other site 402881010008 putative active site [active] 402881010009 catalytic site [active] 402881010010 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 402881010011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 402881010012 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 402881010013 Domain of unknown function DUF20; Region: UPF0118; pfam01594 402881010014 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 402881010015 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 402881010016 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 402881010017 dimerization interface [polypeptide binding]; other site 402881010018 putative ATP binding site [chemical binding]; other site 402881010019 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 402881010020 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 402881010021 active site 402881010022 substrate binding site [chemical binding]; other site 402881010023 cosubstrate binding site; other site 402881010024 catalytic site [active] 402881010025 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 402881010026 active site 402881010027 multimer interface [polypeptide binding]; other site 402881010028 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 402881010029 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 402881010030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 402881010031 ABC transporter; Region: ABC_tran_2; pfam12848 402881010032 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 402881010033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881010034 DNA polymerase III subunit chi; Validated; Region: PRK05728 402881010035 multifunctional aminopeptidase A; Provisional; Region: PRK00913 402881010036 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 402881010037 interface (dimer of trimers) [polypeptide binding]; other site 402881010038 Substrate-binding/catalytic site; other site 402881010039 Zn-binding sites [ion binding]; other site 402881010040 Predicted permeases [General function prediction only]; Region: COG0795 402881010041 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 402881010042 Predicted permeases [General function prediction only]; Region: COG0795 402881010043 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 402881010044 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 402881010045 OstA-like protein; Region: OstA; cl00844 402881010046 Organic solvent tolerance protein; Region: OstA_C; pfam04453 402881010047 SurA N-terminal domain; Region: SurA_N; pfam09312 402881010048 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 402881010049 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 402881010050 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 402881010051 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 402881010052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881010053 S-adenosylmethionine binding site [chemical binding]; other site 402881010054 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 402881010055 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 402881010056 Probable Catalytic site; other site 402881010057 metal-binding site 402881010058 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 402881010059 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 402881010060 putative NAD(P) binding site [chemical binding]; other site 402881010061 catalytic Zn binding site [ion binding]; other site 402881010062 Cephalosporin hydroxylase; Region: CmcI; pfam04989 402881010063 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881010064 Methyltransferase domain; Region: Methyltransf_11; pfam08241 402881010065 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 402881010066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 402881010067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881010068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881010069 active site 402881010070 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 402881010071 active site 402881010072 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 402881010073 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 402881010074 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881010075 Methyltransferase domain; Region: Methyltransf_12; pfam08242 402881010076 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 402881010077 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 402881010078 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 402881010079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881010080 NAD(P) binding site [chemical binding]; other site 402881010081 active site 402881010082 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 402881010083 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 402881010084 substrate binding site; other site 402881010085 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 402881010086 Guanylate kinase; Region: Guanylate_kin; pfam00625 402881010087 catalytic site [active] 402881010088 G-X2-G-X-G-K; other site 402881010089 hypothetical protein; Provisional; Region: PRK11820 402881010090 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 402881010091 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 402881010092 YceG-like family; Region: YceG; pfam02618 402881010093 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 402881010094 dimerization interface [polypeptide binding]; other site 402881010095 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 402881010096 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 402881010097 dimer interface [polypeptide binding]; other site 402881010098 active site 402881010099 acyl carrier protein; Provisional; Region: acpP; PRK00982 402881010100 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 402881010101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881010102 NAD(P) binding site [chemical binding]; other site 402881010103 active site 402881010104 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 402881010105 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 402881010106 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 402881010107 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 402881010108 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 402881010109 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 402881010110 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 402881010111 High-affinity nickel-transport protein; Region: NicO; cl00964 402881010112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881010113 Ligand Binding Site [chemical binding]; other site 402881010114 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 402881010115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881010116 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 402881010117 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 402881010118 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 402881010119 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 402881010120 carboxyltransferase (CT) interaction site; other site 402881010121 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881010122 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 402881010123 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 402881010124 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 402881010125 DNA binding residues [nucleotide binding] 402881010126 dimer interface [polypeptide binding]; other site 402881010127 putative metal binding site [ion binding]; other site 402881010128 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 402881010129 metal-binding site [ion binding] 402881010130 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 402881010131 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 402881010132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881010133 Magnesium ion binding site [ion binding]; other site 402881010134 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 402881010135 ParB-like nuclease domain; Region: ParBc; pfam02195 402881010136 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 402881010137 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 402881010138 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 402881010139 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 402881010140 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 402881010141 dimer interface [polypeptide binding]; other site 402881010142 ssDNA binding site [nucleotide binding]; other site 402881010143 tetramer (dimer of dimers) interface [polypeptide binding]; other site 402881010144 DNA topoisomerase III; Provisional; Region: PRK07726 402881010145 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 402881010146 active site 402881010147 putative interdomain interaction site [polypeptide binding]; other site 402881010148 putative metal-binding site [ion binding]; other site 402881010149 putative nucleotide binding site [chemical binding]; other site 402881010150 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 402881010151 domain I; other site 402881010152 DNA binding groove [nucleotide binding] 402881010153 phosphate binding site [ion binding]; other site 402881010154 domain II; other site 402881010155 domain III; other site 402881010156 nucleotide binding site [chemical binding]; other site 402881010157 catalytic site [active] 402881010158 domain IV; other site 402881010159 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 402881010160 Cation efflux family; Region: Cation_efflux; cl00316 402881010161 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 402881010162 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 402881010163 DNA binding residues [nucleotide binding] 402881010164 dimer interface [polypeptide binding]; other site 402881010165 putative metal binding site [ion binding]; other site 402881010166 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 402881010167 metal-binding site [ion binding] 402881010168 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 402881010169 metal-binding site [ion binding] 402881010170 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 402881010171 metal-binding site [ion binding] 402881010172 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 402881010173 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 402881010174 metal-binding site [ion binding] 402881010175 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881010176 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 402881010177 Herpesvirus UL36 tegument protein; Region: Herpes_UL36; pfam03586 402881010178 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 402881010179 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 402881010180 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 402881010181 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 402881010182 Methyltransferase domain; Region: Methyltransf_26; pfam13659 402881010183 DEAD-like helicases superfamily; Region: DEXDc; smart00487 402881010184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881010185 nucleotide binding region [chemical binding]; other site 402881010186 ATP-binding site [chemical binding]; other site 402881010187 Competence protein CoiA-like family; Region: CoiA; cl11541 402881010188 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 402881010189 Part of AAA domain; Region: AAA_19; pfam13245 402881010190 Family description; Region: UvrD_C_2; pfam13538 402881010191 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 402881010192 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 402881010193 putative active site [active] 402881010194 putative metal-binding site [ion binding]; other site 402881010195 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 402881010196 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 402881010197 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 402881010198 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 402881010199 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 402881010200 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 402881010201 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 402881010202 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 402881010203 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 402881010204 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 402881010205 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 402881010206 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 402881010207 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 402881010208 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 402881010209 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 402881010210 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 402881010211 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 402881010212 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 402881010213 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 402881010214 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 402881010215 catalytic residues [active] 402881010216 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 402881010217 MPN+ (JAMM) motif; other site 402881010218 Zinc-binding site [ion binding]; other site 402881010219 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 402881010220 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 402881010221 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 402881010222 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 402881010223 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 402881010224 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 402881010225 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 402881010226 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 402881010227 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 402881010228 Putative helicase; Region: TraI_2; pfam07514 402881010229 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 402881010230 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 402881010231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881010232 Walker A motif; other site 402881010233 ATP binding site [chemical binding]; other site 402881010234 Walker B motif; other site 402881010235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 402881010236 Helix-turn-helix domain; Region: HTH_28; pfam13518 402881010237 HTH-like domain; Region: HTH_21; pfam13276 402881010238 Integrase core domain; Region: rve; pfam00665 402881010239 Integrase core domain; Region: rve_2; pfam13333 402881010240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 402881010241 Putative serine esterase (DUF676); Region: DUF676; pfam05057 402881010242 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 402881010243 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 402881010244 HlyD family secretion protein; Region: HlyD; pfam00529 402881010245 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 402881010246 HlyD family secretion protein; Region: HlyD_3; pfam13437 402881010247 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 402881010248 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 402881010249 Walker A/P-loop; other site 402881010250 ATP binding site [chemical binding]; other site 402881010251 Q-loop/lid; other site 402881010252 ABC transporter signature motif; other site 402881010253 Walker B; other site 402881010254 D-loop; other site 402881010255 H-loop/switch region; other site 402881010256 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 402881010257 Walker A/P-loop; other site 402881010258 ATP binding site [chemical binding]; other site 402881010259 Q-loop/lid; other site 402881010260 ABC transporter signature motif; other site 402881010261 Walker B; other site 402881010262 D-loop; other site 402881010263 H-loop/switch region; other site 402881010264 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881010265 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 402881010266 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 402881010267 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 402881010268 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 402881010269 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 402881010270 NAD(P) binding site [chemical binding]; other site 402881010271 homotetramer interface [polypeptide binding]; other site 402881010272 homodimer interface [polypeptide binding]; other site 402881010273 active site 402881010274 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 402881010275 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 402881010276 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 402881010277 dimer interaction site [polypeptide binding]; other site 402881010278 substrate-binding tunnel; other site 402881010279 active site 402881010280 catalytic site [active] 402881010281 substrate binding site [chemical binding]; other site 402881010282 phosphate acetyltransferase; Provisional; Region: PRK11890 402881010283 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 402881010284 classical (c) SDRs; Region: SDR_c; cd05233 402881010285 NAD(P) binding site [chemical binding]; other site 402881010286 active site 402881010287 propionate/acetate kinase; Provisional; Region: PRK12379 402881010288 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 402881010289 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 402881010290 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 402881010291 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 402881010292 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 402881010293 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881010294 Ligand Binding Site [chemical binding]; other site 402881010295 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 402881010296 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 402881010297 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 402881010298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881010299 active site 402881010300 XFP N-terminal domain; Region: XFP_N; pfam09364 402881010301 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 402881010302 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 402881010303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 402881010304 Beta-Casp domain; Region: Beta-Casp; smart01027 402881010305 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 402881010306 thymidine phosphorylase; Provisional; Region: PRK04350 402881010307 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 402881010308 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 402881010309 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 402881010310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881010311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881010312 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 402881010313 dimerization interface [polypeptide binding]; other site 402881010314 substrate binding pocket [chemical binding]; other site 402881010315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881010316 sequence-specific DNA binding site [nucleotide binding]; other site 402881010317 salt bridge; other site 402881010318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881010319 LysR substrate binding domain; Region: LysR_substrate; pfam03466 402881010320 dimerization interface [polypeptide binding]; other site 402881010321 integrase; Provisional; Region: PRK09692 402881010322 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 402881010323 active site 402881010324 Int/Topo IB signature motif; other site 402881010325 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 402881010326 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 402881010327 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 402881010328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 402881010329 Protein of unknown function (DUF433); Region: DUF433; pfam04255 402881010330 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 402881010331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 402881010332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881010333 S-adenosylmethionine binding site [chemical binding]; other site 402881010334 Predicted membrane protein [Function unknown]; Region: COG2259 402881010335 replicative DNA helicase; Provisional; Region: PRK09165 402881010336 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 402881010337 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 402881010338 Walker A motif; other site 402881010339 ATP binding site [chemical binding]; other site 402881010340 Walker B motif; other site 402881010341 DNA binding loops [nucleotide binding] 402881010342 FOG: CBS domain [General function prediction only]; Region: COG0517 402881010343 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 402881010344 Nitrogen regulatory protein P-II; Region: P-II; smart00938 402881010345 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 402881010346 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 402881010347 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881010348 Ligand Binding Site [chemical binding]; other site 402881010349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881010350 Ligand Binding Site [chemical binding]; other site 402881010351 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 402881010352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881010353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881010354 dimer interface [polypeptide binding]; other site 402881010355 phosphorylation site [posttranslational modification] 402881010356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881010357 ATP binding site [chemical binding]; other site 402881010358 Mg2+ binding site [ion binding]; other site 402881010359 G-X-G motif; other site 402881010360 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 402881010361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 402881010362 active site 402881010363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 402881010364 dimer interface [polypeptide binding]; other site 402881010365 substrate binding site [chemical binding]; other site 402881010366 catalytic residues [active] 402881010367 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 402881010368 Permease; Region: Permease; pfam02405 402881010369 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 402881010370 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 402881010371 Walker A/P-loop; other site 402881010372 ATP binding site [chemical binding]; other site 402881010373 Q-loop/lid; other site 402881010374 ABC transporter signature motif; other site 402881010375 Walker B; other site 402881010376 D-loop; other site 402881010377 H-loop/switch region; other site 402881010378 DNA repair protein RadA; Provisional; Region: PRK11823 402881010379 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 402881010380 Walker A motif/ATP binding site; other site 402881010381 ATP binding site [chemical binding]; other site 402881010382 Walker B motif; other site 402881010383 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 402881010384 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 402881010385 Colicin V production protein; Region: Colicin_V; pfam02674 402881010386 amidophosphoribosyltransferase; Provisional; Region: PRK09123 402881010387 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 402881010388 active site 402881010389 tetramer interface [polypeptide binding]; other site 402881010390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 402881010391 active site 402881010392 short chain dehydrogenase; Provisional; Region: PRK08703 402881010393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881010394 NAD(P) binding site [chemical binding]; other site 402881010395 active site 402881010396 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881010397 Predicted transcriptional regulators [Transcription]; Region: COG1733 402881010398 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 402881010399 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 402881010400 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 402881010401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881010402 putative active site [active] 402881010403 heme pocket [chemical binding]; other site 402881010404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881010405 dimer interface [polypeptide binding]; other site 402881010406 phosphorylation site [posttranslational modification] 402881010407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881010408 ATP binding site [chemical binding]; other site 402881010409 G-X-G motif; other site 402881010410 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 402881010411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881010412 active site 402881010413 phosphorylation site [posttranslational modification] 402881010414 intermolecular recognition site; other site 402881010415 dimerization interface [polypeptide binding]; other site 402881010416 Response regulator receiver domain; Region: Response_reg; pfam00072 402881010417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881010418 active site 402881010419 phosphorylation site [posttranslational modification] 402881010420 intermolecular recognition site; other site 402881010421 dimerization interface [polypeptide binding]; other site 402881010422 GTP-binding protein Der; Reviewed; Region: PRK00093 402881010423 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 402881010424 G1 box; other site 402881010425 GTP/Mg2+ binding site [chemical binding]; other site 402881010426 Switch I region; other site 402881010427 G2 box; other site 402881010428 Switch II region; other site 402881010429 G3 box; other site 402881010430 G4 box; other site 402881010431 G5 box; other site 402881010432 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 402881010433 G1 box; other site 402881010434 GTP/Mg2+ binding site [chemical binding]; other site 402881010435 Switch I region; other site 402881010436 G2 box; other site 402881010437 G3 box; other site 402881010438 Switch II region; other site 402881010439 G4 box; other site 402881010440 G5 box; other site 402881010441 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 402881010442 Trp docking motif [polypeptide binding]; other site 402881010443 active site 402881010444 PQQ-like domain; Region: PQQ_2; pfam13360 402881010445 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 402881010446 active site 402881010447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 402881010448 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 402881010449 oligomerization interface [polypeptide binding]; other site 402881010450 active site 402881010451 metal binding site [ion binding]; metal-binding site 402881010452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881010453 binding surface 402881010454 TPR motif; other site 402881010455 TPR repeat; Region: TPR_11; pfam13414 402881010456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 402881010457 binding surface 402881010458 TPR motif; other site 402881010459 TPR repeat; Region: TPR_11; pfam13414 402881010460 SnoaL-like domain; Region: SnoaL_2; pfam12680 402881010461 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 402881010462 Cytochrome P450; Region: p450; cl12078 402881010463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 402881010464 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 402881010465 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 402881010466 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 402881010467 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 402881010468 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881010469 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 402881010470 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 402881010471 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 402881010472 dimer interface [polypeptide binding]; other site 402881010473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 402881010474 dimerization interface [polypeptide binding]; other site 402881010475 putative DNA binding site [nucleotide binding]; other site 402881010476 putative Zn2+ binding site [ion binding]; other site 402881010477 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 402881010478 Intracellular septation protein A; Region: IspA; pfam04279 402881010479 short chain dehydrogenase; Provisional; Region: PRK07109 402881010480 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 402881010481 putative NAD(P) binding site [chemical binding]; other site 402881010482 active site 402881010483 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 402881010484 AAA domain; Region: AAA_30; pfam13604 402881010485 Family description; Region: UvrD_C_2; pfam13538 402881010486 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 402881010487 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 402881010488 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 402881010489 ParB-like nuclease domain; Region: ParB; smart00470 402881010490 Methyltransferase domain; Region: Methyltransf_26; pfam13659 402881010491 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 402881010492 Helicase_C-like; Region: Helicase_C_4; pfam13871 402881010493 Toprim domain; Region: Toprim_3; pfam13362 402881010494 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 402881010495 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 402881010496 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 402881010497 oligomeric interface; other site 402881010498 putative active site [active] 402881010499 homodimer interface [polypeptide binding]; other site 402881010500 Uncharacterized conserved protein [Function unknown]; Region: COG5489 402881010501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 402881010502 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 402881010503 Helix-turn-helix domain; Region: HTH_17; pfam12728 402881010504 Replication initiator protein A; Region: RPA; pfam10134 402881010505 ParA-like protein; Provisional; Region: PHA02518 402881010506 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 402881010507 P-loop; other site 402881010508 Magnesium ion binding site [ion binding]; other site 402881010509 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 402881010510 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 402881010511 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 402881010512 Protein of unknown function (DUF736); Region: DUF736; pfam05284 402881010513 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 402881010514 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 402881010515 N-acetyl-D-glucosamine binding site [chemical binding]; other site 402881010516 catalytic residue [active] 402881010517 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 402881010518 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 402881010519 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 402881010520 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 402881010521 Walker A motif; other site 402881010522 ATP binding site [chemical binding]; other site 402881010523 Walker B motif; other site 402881010524 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 402881010525 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 402881010526 Walker A motif; other site 402881010527 ATP binding site [chemical binding]; other site 402881010528 Walker B motif; other site 402881010529 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 402881010530 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 402881010531 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 402881010532 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 402881010533 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 402881010534 Walker A motif; other site 402881010535 ATP binding site [chemical binding]; other site 402881010536 Walker B motif; other site 402881010537 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 402881010538 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 402881010539 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 402881010540 conjugal transfer protein TrbL; Provisional; Region: PRK13875 402881010541 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 402881010542 conjugal transfer protein TrbF; Provisional; Region: PRK13872 402881010543 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 402881010544 VirB7 interaction site; other site 402881010545 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 402881010546 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 402881010547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 402881010548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 402881010549 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 402881010550 dimerization interface [polypeptide binding]; other site 402881010551 substrate binding pocket [chemical binding]; other site 402881010552 Helix-turn-helix domain; Region: HTH_17; pfam12728 402881010553 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 402881010554 Divergent AAA domain; Region: AAA_4; pfam04326 402881010555 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 402881010556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881010557 ATP binding site [chemical binding]; other site 402881010558 Mg2+ binding site [ion binding]; other site 402881010559 G-X-G motif; other site 402881010560 DNA methylase; Region: N6_N4_Mtase; cl17433 402881010561 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 402881010562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 402881010563 ATP binding site [chemical binding]; other site 402881010564 putative Mg++ binding site [ion binding]; other site 402881010565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 402881010566 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 402881010567 nucleotide binding region [chemical binding]; other site 402881010568 ATP-binding site [chemical binding]; other site 402881010569 PglZ domain; Region: PglZ; pfam08665 402881010570 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 402881010571 integrase; Provisional; Region: PRK09692 402881010572 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 402881010573 active site 402881010574 Int/Topo IB signature motif; other site 402881010575 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 402881010576 MarR family; Region: MarR; pfam01047 402881010577 CysZ-like protein; Reviewed; Region: PRK12768 402881010578 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 402881010579 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 402881010580 minor groove reading motif; other site 402881010581 helix-hairpin-helix signature motif; other site 402881010582 substrate binding pocket [chemical binding]; other site 402881010583 active site 402881010584 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 402881010585 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 402881010586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 402881010587 catalytic core [active] 402881010588 dihydrodipicolinate reductase; Provisional; Region: PRK00048 402881010589 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 402881010590 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 402881010591 Protein of unknown function, DUF486; Region: DUF486; cl01236 402881010592 chaperone protein DnaJ; Provisional; Region: PRK10767 402881010593 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 402881010594 HSP70 interaction site [polypeptide binding]; other site 402881010595 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 402881010596 substrate binding site [polypeptide binding]; other site 402881010597 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 402881010598 Zn binding sites [ion binding]; other site 402881010599 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 402881010600 dimer interface [polypeptide binding]; other site 402881010601 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 402881010602 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 402881010603 nucleotide binding site [chemical binding]; other site 402881010604 NEF interaction site [polypeptide binding]; other site 402881010605 SBD interface [polypeptide binding]; other site 402881010606 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 402881010607 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 402881010608 NnrU protein; Region: NnrU; pfam07298 402881010609 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 402881010610 dimer interface [polypeptide binding]; other site 402881010611 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 402881010612 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 402881010613 ribonuclease PH; Reviewed; Region: rph; PRK00173 402881010614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 402881010615 hexamer interface [polypeptide binding]; other site 402881010616 active site 402881010617 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 402881010618 active site 402881010619 dimerization interface [polypeptide binding]; other site 402881010620 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 402881010621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881010622 FeS/SAM binding site; other site 402881010623 HemN C-terminal domain; Region: HemN_C; pfam06969 402881010624 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 402881010625 maleylacetoacetate isomerase; Region: maiA; TIGR01262 402881010626 C-terminal domain interface [polypeptide binding]; other site 402881010627 GSH binding site (G-site) [chemical binding]; other site 402881010628 putative dimer interface [polypeptide binding]; other site 402881010629 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 402881010630 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 402881010631 N-terminal domain interface [polypeptide binding]; other site 402881010632 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 402881010633 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 402881010634 putative ligand binding site [chemical binding]; other site 402881010635 Predicted methyltransferases [General function prediction only]; Region: COG0313 402881010636 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 402881010637 putative SAM binding site [chemical binding]; other site 402881010638 putative homodimer interface [polypeptide binding]; other site 402881010639 hypothetical protein; Reviewed; Region: PRK12497 402881010640 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 402881010641 BON domain; Region: BON; pfam04972 402881010642 BON domain; Region: BON; pfam04972 402881010643 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 402881010644 glutathione synthetase; Provisional; Region: PRK05246 402881010645 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 402881010646 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 402881010647 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 402881010648 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 402881010649 active site 402881010650 dimer interface [polypeptide binding]; other site 402881010651 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 402881010652 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 402881010653 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 402881010654 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 402881010655 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 402881010656 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 402881010657 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 402881010658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 402881010659 Walker A motif; other site 402881010660 ATP binding site [chemical binding]; other site 402881010661 Walker B motif; other site 402881010662 arginine finger; other site 402881010663 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 402881010664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 402881010665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881010666 putative active site [active] 402881010667 heme pocket [chemical binding]; other site 402881010668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881010669 dimer interface [polypeptide binding]; other site 402881010670 phosphorylation site [posttranslational modification] 402881010671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881010672 ATP binding site [chemical binding]; other site 402881010673 Mg2+ binding site [ion binding]; other site 402881010674 G-X-G motif; other site 402881010675 Response regulator receiver domain; Region: Response_reg; pfam00072 402881010676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881010677 active site 402881010678 phosphorylation site [posttranslational modification] 402881010679 intermolecular recognition site; other site 402881010680 dimerization interface [polypeptide binding]; other site 402881010681 muropeptide transporter; Reviewed; Region: ampG; PRK11902 402881010682 muropeptide transporter; Validated; Region: ampG; cl17669 402881010683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 402881010684 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 402881010685 Malic enzyme, N-terminal domain; Region: malic; pfam00390 402881010686 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 402881010687 putative NAD(P) binding site [chemical binding]; other site 402881010688 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 402881010689 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 402881010690 MutS domain I; Region: MutS_I; pfam01624 402881010691 MutS domain II; Region: MutS_II; pfam05188 402881010692 MutS domain III; Region: MutS_III; pfam05192 402881010693 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 402881010694 Walker A/P-loop; other site 402881010695 ATP binding site [chemical binding]; other site 402881010696 Q-loop/lid; other site 402881010697 ABC transporter signature motif; other site 402881010698 Walker B; other site 402881010699 D-loop; other site 402881010700 H-loop/switch region; other site 402881010701 Methyltransferase domain; Region: Methyltransf_23; pfam13489 402881010702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881010703 PII uridylyl-transferase; Provisional; Region: PRK05092 402881010704 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 402881010705 metal binding triad; other site 402881010706 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 402881010707 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 402881010708 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 402881010709 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 402881010710 integral membrane protein MviN; Region: mviN; TIGR01695 402881010711 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 402881010712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 402881010713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 402881010714 dimer interface [polypeptide binding]; other site 402881010715 phosphorylation site [posttranslational modification] 402881010716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 402881010717 ATP binding site [chemical binding]; other site 402881010718 Mg2+ binding site [ion binding]; other site 402881010719 G-X-G motif; other site 402881010720 Response regulator receiver domain; Region: Response_reg; pfam00072 402881010721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881010722 active site 402881010723 phosphorylation site [posttranslational modification] 402881010724 intermolecular recognition site; other site 402881010725 dimerization interface [polypeptide binding]; other site 402881010726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 402881010727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 402881010728 active site 402881010729 phosphorylation site [posttranslational modification] 402881010730 intermolecular recognition site; other site 402881010731 dimerization interface [polypeptide binding]; other site 402881010732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 402881010733 DNA binding residues [nucleotide binding] 402881010734 Autotransporter beta-domain; Region: Autotransporter; pfam03797 402881010735 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 402881010736 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 402881010737 active site 402881010738 HIGH motif; other site 402881010739 dimer interface [polypeptide binding]; other site 402881010740 KMSKS motif; other site 402881010741 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 402881010742 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 402881010743 Ligand Binding Site [chemical binding]; other site 402881010744 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 402881010745 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 402881010746 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 402881010747 putative FMN binding site [chemical binding]; other site 402881010748 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 402881010749 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 402881010750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 402881010751 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 402881010752 metal binding site 2 [ion binding]; metal-binding site 402881010753 putative DNA binding helix; other site 402881010754 metal binding site 1 [ion binding]; metal-binding site 402881010755 dimer interface [polypeptide binding]; other site 402881010756 structural Zn2+ binding site [ion binding]; other site 402881010757 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 402881010758 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 402881010759 putative acyl-acceptor binding pocket; other site 402881010760 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 402881010761 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 402881010762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 402881010763 FeS/SAM binding site; other site 402881010764 TRAM domain; Region: TRAM; cl01282 402881010765 PhoH-like protein; Region: PhoH; pfam02562 402881010766 DEAD-like helicases superfamily; Region: DEXDc; smart00487 402881010767 metal-binding heat shock protein; Provisional; Region: PRK00016 402881010768 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 402881010769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 402881010770 Transporter associated domain; Region: CorC_HlyC; smart01091 402881010771 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 402881010772 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 402881010773 putative active site [active] 402881010774 catalytic triad [active] 402881010775 putative dimer interface [polypeptide binding]; other site 402881010776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 402881010777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881010778 sequence-specific DNA binding site [nucleotide binding]; other site 402881010779 salt bridge; other site 402881010780 S-adenosylmethionine synthetase; Validated; Region: PRK05250 402881010781 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 402881010782 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 402881010783 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 402881010784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881010785 S-adenosylmethionine binding site [chemical binding]; other site 402881010786 ribosome maturation protein RimP; Reviewed; Region: PRK00092 402881010787 Sm and related proteins; Region: Sm_like; cl00259 402881010788 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 402881010789 putative oligomer interface [polypeptide binding]; other site 402881010790 putative RNA binding site [nucleotide binding]; other site 402881010791 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 402881010792 NusA N-terminal domain; Region: NusA_N; pfam08529 402881010793 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 402881010794 RNA binding site [nucleotide binding]; other site 402881010795 homodimer interface [polypeptide binding]; other site 402881010796 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 402881010797 G-X-X-G motif; other site 402881010798 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 402881010799 G-X-X-G motif; other site 402881010800 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 402881010801 hypothetical protein; Provisional; Region: PRK09190 402881010802 Protein of unknown function (DUF448); Region: DUF448; pfam04296 402881010803 putative RNA binding cleft [nucleotide binding]; other site 402881010804 translation initiation factor IF-2; Region: IF-2; TIGR00487 402881010805 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 402881010806 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 402881010807 G1 box; other site 402881010808 putative GEF interaction site [polypeptide binding]; other site 402881010809 GTP/Mg2+ binding site [chemical binding]; other site 402881010810 Switch I region; other site 402881010811 G2 box; other site 402881010812 G3 box; other site 402881010813 Switch II region; other site 402881010814 G4 box; other site 402881010815 G5 box; other site 402881010816 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 402881010817 Translation-initiation factor 2; Region: IF-2; pfam11987 402881010818 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 402881010819 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 402881010820 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 402881010821 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 402881010822 RNA binding site [nucleotide binding]; other site 402881010823 active site 402881010824 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 402881010825 16S/18S rRNA binding site [nucleotide binding]; other site 402881010826 S13e-L30e interaction site [polypeptide binding]; other site 402881010827 25S rRNA binding site [nucleotide binding]; other site 402881010828 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 402881010829 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 402881010830 RNase E interface [polypeptide binding]; other site 402881010831 trimer interface [polypeptide binding]; other site 402881010832 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 402881010833 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 402881010834 RNase E interface [polypeptide binding]; other site 402881010835 trimer interface [polypeptide binding]; other site 402881010836 active site 402881010837 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 402881010838 putative nucleic acid binding region [nucleotide binding]; other site 402881010839 G-X-X-G motif; other site 402881010840 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 402881010841 RNA binding site [nucleotide binding]; other site 402881010842 domain interface; other site 402881010843 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 402881010844 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 402881010845 NAD binding site [chemical binding]; other site 402881010846 homotetramer interface [polypeptide binding]; other site 402881010847 homodimer interface [polypeptide binding]; other site 402881010848 substrate binding site [chemical binding]; other site 402881010849 active site 402881010850 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 402881010851 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 402881010852 dimer interface [polypeptide binding]; other site 402881010853 active site 402881010854 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 402881010855 active site 2 [active] 402881010856 active site 1 [active] 402881010857 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 402881010858 metal binding site 2 [ion binding]; metal-binding site 402881010859 putative DNA binding helix; other site 402881010860 metal binding site 1 [ion binding]; metal-binding site 402881010861 dimer interface [polypeptide binding]; other site 402881010862 Rubrerythrin [Energy production and conversion]; Region: COG1592 402881010863 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 402881010864 binuclear metal center [ion binding]; other site 402881010865 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 402881010866 Cysteine-rich domain; Region: CCG; pfam02754 402881010867 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 402881010868 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 402881010869 Sulfatase; Region: Sulfatase; pfam00884 402881010870 Bacterial SH3 domain; Region: SH3_4; pfam06347 402881010871 Bacterial SH3 domain; Region: SH3_4; pfam06347 402881010872 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 402881010873 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 402881010874 dimerization interface [polypeptide binding]; other site 402881010875 ligand binding site [chemical binding]; other site 402881010876 NADP binding site [chemical binding]; other site 402881010877 catalytic site [active] 402881010878 Predicted transcriptional regulator [Transcription]; Region: COG2944 402881010879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 402881010880 non-specific DNA binding site [nucleotide binding]; other site 402881010881 salt bridge; other site 402881010882 sequence-specific DNA binding site [nucleotide binding]; other site 402881010883 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 402881010884 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 402881010885 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 402881010886 ATP binding site [chemical binding]; other site 402881010887 substrate interface [chemical binding]; other site 402881010888 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 402881010889 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 402881010890 CoenzymeA binding site [chemical binding]; other site 402881010891 subunit interaction site [polypeptide binding]; other site 402881010892 PHB binding site; other site 402881010893 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 402881010894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 402881010895 NAD(P) binding site [chemical binding]; other site 402881010896 active site 402881010897 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 402881010898 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 402881010899 putative catalytic residue [active] 402881010900 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 402881010901 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 402881010902 putative catalytic residue [active] 402881010903 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 402881010904 putative NAD(P) binding site [chemical binding]; other site 402881010905 active site 402881010906 Predicted transcriptional regulators [Transcription]; Region: COG1733 402881010907 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 402881010908 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 402881010909 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 402881010910 dimer interface [polypeptide binding]; other site 402881010911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 402881010912 catalytic residue [active] 402881010913 Rrf2 family protein; Region: rrf2_super; TIGR00738 402881010914 Transcriptional regulator; Region: Rrf2; pfam02082 402881010915 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 402881010916 trimer interface [polypeptide binding]; other site 402881010917 active site 402881010918 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 402881010919 Flavoprotein; Region: Flavoprotein; pfam02441 402881010920 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 402881010921 ABC1 family; Region: ABC1; cl17513 402881010922 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 402881010923 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 402881010924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 402881010925 S-adenosylmethionine binding site [chemical binding]; other site 402881010926 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 402881010927 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 402881010928 DNA binding site [nucleotide binding] 402881010929 catalytic residue [active] 402881010930 H2TH interface [polypeptide binding]; other site 402881010931 putative catalytic residues [active] 402881010932 turnover-facilitating residue; other site 402881010933 intercalation triad [nucleotide binding]; other site 402881010934 8OG recognition residue [nucleotide binding]; other site 402881010935 putative reading head residues; other site 402881010936 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 402881010937 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 402881010938 enoyl-CoA hydratase; Provisional; Region: PRK05862 402881010939 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 402881010940 substrate binding site [chemical binding]; other site 402881010941 oxyanion hole (OAH) forming residues; other site 402881010942 trimer interface [polypeptide binding]; other site