-- dump date   	20140619_231454
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
318586000001	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
318586000002	transcription termination factor Rho; Provisional; Region: rho; PRK09376
318586000003	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
318586000004	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
318586000005	RNA binding site [nucleotide binding]; other site
318586000006	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
318586000007	multimer interface [polypeptide binding]; other site
318586000008	Walker A motif; other site
318586000009	ATP binding site [chemical binding]; other site
318586000010	Walker B motif; other site
318586000011	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
318586000012	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
318586000013	trmE is a tRNA modification GTPase; Region: trmE; cd04164
318586000014	G1 box; other site
318586000015	GTP/Mg2+ binding site [chemical binding]; other site
318586000016	Switch I region; other site
318586000017	G2 box; other site
318586000018	Switch II region; other site
318586000019	G3 box; other site
318586000020	G4 box; other site
318586000021	G5 box; other site
318586000022	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
318586000023	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
318586000024	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
318586000025	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
318586000026	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
318586000027	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
318586000028	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
318586000029	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586000030	P-loop; other site
318586000031	Magnesium ion binding site [ion binding]; other site
318586000032	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
318586000033	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586000034	Magnesium ion binding site [ion binding]; other site
318586000035	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
318586000036	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
318586000037	ParB-like nuclease domain; Region: ParB; smart00470
318586000038	GrpE; Region: GrpE; pfam01025
318586000039	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
318586000040	dimer interface [polypeptide binding]; other site
318586000041	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
318586000042	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
318586000043	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
318586000044	ribonuclease PH; Reviewed; Region: rph; PRK00173
318586000045	Ribonuclease PH; Region: RNase_PH_bact; cd11362
318586000046	hexamer interface [polypeptide binding]; other site
318586000047	active site
318586000048	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
318586000049	active site
318586000050	dimerization interface [polypeptide binding]; other site
318586000051	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
318586000052	homotrimer interaction site [polypeptide binding]; other site
318586000053	putative active site [active]
318586000054	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
318586000055	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586000056	FeS/SAM binding site; other site
318586000057	HemN C-terminal domain; Region: HemN_C; pfam06969
318586000058	Protein of unknown function (DUF454); Region: DUF454; cl01063
318586000059	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
318586000060	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
318586000061	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
318586000062	substrate binding site [chemical binding]; other site
318586000063	catalytic Zn binding site [ion binding]; other site
318586000064	NAD binding site [chemical binding]; other site
318586000065	structural Zn binding site [ion binding]; other site
318586000066	dimer interface [polypeptide binding]; other site
318586000067	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
318586000068	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
318586000069	oligomer interface [polypeptide binding]; other site
318586000070	active site residues [active]
318586000071	putative acetyltransferase; Provisional; Region: PRK03624
318586000072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586000073	Coenzyme A binding pocket [chemical binding]; other site
318586000074	S-formylglutathione hydrolase; Region: PLN02442
318586000075	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
318586000076	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
318586000077	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
318586000078	Trp docking motif [polypeptide binding]; other site
318586000079	dimer interface [polypeptide binding]; other site
318586000080	active site
318586000081	small subunit binding site [polypeptide binding]; other site
318586000082	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
318586000083	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
318586000084	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
318586000085	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586000086	substrate binding pocket [chemical binding]; other site
318586000087	membrane-bound complex binding site; other site
318586000088	hinge residues; other site
318586000089	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
318586000090	active site residue [active]
318586000091	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
318586000092	putative hydrophobic ligand binding site [chemical binding]; other site
318586000093	protein interface [polypeptide binding]; other site
318586000094	gate; other site
318586000095	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
318586000096	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
318586000097	ligand binding site [chemical binding]; other site
318586000098	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
318586000099	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
318586000100	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
318586000101	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
318586000102	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
318586000103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586000104	Walker A/P-loop; other site
318586000105	ATP binding site [chemical binding]; other site
318586000106	Q-loop/lid; other site
318586000107	ABC transporter signature motif; other site
318586000108	Walker B; other site
318586000109	D-loop; other site
318586000110	H-loop/switch region; other site
318586000111	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
318586000112	ABC-2 type transporter; Region: ABC2_membrane; cl17235
318586000113	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
318586000114	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
318586000115	GTP binding site; other site
318586000116	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586000117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586000118	dimer interface [polypeptide binding]; other site
318586000119	conserved gate region; other site
318586000120	putative PBP binding loops; other site
318586000121	ABC-ATPase subunit interface; other site
318586000122	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586000123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586000124	Walker A/P-loop; other site
318586000125	ATP binding site [chemical binding]; other site
318586000126	Q-loop/lid; other site
318586000127	ABC transporter signature motif; other site
318586000128	Walker B; other site
318586000129	D-loop; other site
318586000130	H-loop/switch region; other site
318586000131	Putative transcription activator [Transcription]; Region: TenA; COG0819
318586000132	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
318586000133	NMT1/THI5 like; Region: NMT1; pfam09084
318586000134	membrane-bound complex binding site; other site
318586000135	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
318586000136	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
318586000137	ATP binding site [chemical binding]; other site
318586000138	substrate interface [chemical binding]; other site
318586000139	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
318586000140	active site residue [active]
318586000141	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
318586000142	thiamine phosphate binding site [chemical binding]; other site
318586000143	active site
318586000144	pyrophosphate binding site [ion binding]; other site
318586000145	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
318586000146	ThiS interaction site; other site
318586000147	putative active site [active]
318586000148	tetramer interface [polypeptide binding]; other site
318586000149	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
318586000150	thiS-thiF/thiG interaction site; other site
318586000151	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586000152	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
318586000153	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
318586000154	dimer interface [polypeptide binding]; other site
318586000155	substrate binding site [chemical binding]; other site
318586000156	ATP binding site [chemical binding]; other site
318586000157	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
318586000158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586000159	motif II; other site
318586000160	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586000161	Dehydroquinase class II; Region: DHquinase_II; pfam01220
318586000162	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
318586000163	trimer interface [polypeptide binding]; other site
318586000164	active site
318586000165	dimer interface [polypeptide binding]; other site
318586000166	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586000167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586000168	active site
318586000169	phosphorylation site [posttranslational modification]
318586000170	intermolecular recognition site; other site
318586000171	dimerization interface [polypeptide binding]; other site
318586000172	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586000173	DNA binding site [nucleotide binding]
318586000174	PAS fold; Region: PAS_7; pfam12860
318586000175	PAS fold; Region: PAS_4; pfam08448
318586000176	histidine kinase; Provisional; Region: PRK13557
318586000177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586000178	ATP binding site [chemical binding]; other site
318586000179	Mg2+ binding site [ion binding]; other site
318586000180	G-X-G motif; other site
318586000181	Response regulator receiver domain; Region: Response_reg; pfam00072
318586000182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586000183	active site
318586000184	phosphorylation site [posttranslational modification]
318586000185	intermolecular recognition site; other site
318586000186	dimerization interface [polypeptide binding]; other site
318586000187	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
318586000188	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586000189	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
318586000190	acyl-activating enzyme (AAE) consensus motif; other site
318586000191	putative AMP binding site [chemical binding]; other site
318586000192	putative active site [active]
318586000193	putative CoA binding site [chemical binding]; other site
318586000194	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586000195	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586000196	Walker A/P-loop; other site
318586000197	ATP binding site [chemical binding]; other site
318586000198	Q-loop/lid; other site
318586000199	ABC transporter signature motif; other site
318586000200	Walker B; other site
318586000201	D-loop; other site
318586000202	H-loop/switch region; other site
318586000203	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586000204	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586000205	TM-ABC transporter signature motif; other site
318586000206	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586000207	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586000208	TM-ABC transporter signature motif; other site
318586000209	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
318586000210	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586000211	putative ligand binding site [chemical binding]; other site
318586000212	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586000213	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586000214	Walker A/P-loop; other site
318586000215	ATP binding site [chemical binding]; other site
318586000216	Q-loop/lid; other site
318586000217	ABC transporter signature motif; other site
318586000218	Walker B; other site
318586000219	D-loop; other site
318586000220	H-loop/switch region; other site
318586000221	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
318586000222	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586000223	acyl-activating enzyme (AAE) consensus motif; other site
318586000224	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586000225	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
318586000226	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
318586000227	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
318586000228	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
318586000229	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
318586000230	nudix motif; other site
318586000231	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
318586000232	C-terminal domain interface [polypeptide binding]; other site
318586000233	GSH binding site (G-site) [chemical binding]; other site
318586000234	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586000235	dimer interface [polypeptide binding]; other site
318586000236	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586000237	N-terminal domain interface [polypeptide binding]; other site
318586000238	dimer interface [polypeptide binding]; other site
318586000239	substrate binding pocket (H-site) [chemical binding]; other site
318586000240	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
318586000241	active site
318586000242	dimer interface [polypeptide binding]; other site
318586000243	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
318586000244	Clp amino terminal domain; Region: Clp_N; pfam02861
318586000245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586000246	Walker A motif; other site
318586000247	ATP binding site [chemical binding]; other site
318586000248	Walker B motif; other site
318586000249	arginine finger; other site
318586000250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586000251	Walker A motif; other site
318586000252	ATP binding site [chemical binding]; other site
318586000253	Walker B motif; other site
318586000254	arginine finger; other site
318586000255	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
318586000256	TMAO/DMSO reductase; Reviewed; Region: PRK05363
318586000257	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
318586000258	Moco binding site; other site
318586000259	metal coordination site [ion binding]; other site
318586000260	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
318586000261	Predicted helicase [General function prediction only]; Region: COG4889
318586000262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586000263	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
318586000264	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
318586000265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586000266	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
318586000267	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586000268	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
318586000269	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
318586000270	putative active site; other site
318586000271	signature motif; other site
318586000272	putative triphosphate binding site [ion binding]; other site
318586000273	CHAD domain; Region: CHAD; pfam05235
318586000274	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
318586000275	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586000276	P-loop; other site
318586000277	Magnesium ion binding site [ion binding]; other site
318586000278	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586000279	Magnesium ion binding site [ion binding]; other site
318586000280	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
318586000281	putative active site [active]
318586000282	putative metal binding residues [ion binding]; other site
318586000283	signature motif; other site
318586000284	putative dimer interface [polypeptide binding]; other site
318586000285	putative phosphate binding site [ion binding]; other site
318586000286	Predicted acetyltransferase [General function prediction only]; Region: COG2388
318586000287	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
318586000288	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586000289	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586000290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586000291	active site
318586000292	phosphorylation site [posttranslational modification]
318586000293	intermolecular recognition site; other site
318586000294	dimerization interface [polypeptide binding]; other site
318586000295	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586000296	DNA binding site [nucleotide binding]
318586000297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
318586000298	putative active site [active]
318586000299	heme pocket [chemical binding]; other site
318586000300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586000301	dimer interface [polypeptide binding]; other site
318586000302	phosphorylation site [posttranslational modification]
318586000303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586000304	ATP binding site [chemical binding]; other site
318586000305	Mg2+ binding site [ion binding]; other site
318586000306	G-X-G motif; other site
318586000307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586000308	active site
318586000309	phosphorylation site [posttranslational modification]
318586000310	intermolecular recognition site; other site
318586000311	dimerization interface [polypeptide binding]; other site
318586000312	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586000313	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
318586000314	DNA binding residues [nucleotide binding]
318586000315	dimerization interface [polypeptide binding]; other site
318586000316	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
318586000317	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
318586000318	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
318586000319	ligand binding site; other site
318586000320	tetramer interface; other site
318586000321	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
318586000322	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
318586000323	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
318586000324	metal binding site [ion binding]; metal-binding site
318586000325	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653
318586000326	putative active site [active]
318586000327	putative substrate binding site [chemical binding]; other site
318586000328	putative cosubstrate binding site; other site
318586000329	catalytic site [active]
318586000330	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
318586000331	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
318586000332	NAD(P) binding site [chemical binding]; other site
318586000333	homodimer interface [polypeptide binding]; other site
318586000334	substrate binding site [chemical binding]; other site
318586000335	active site
318586000336	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586000337	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586000338	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
318586000339	catalytic residues [active]
318586000340	catalytic nucleophile [active]
318586000341	Presynaptic Site I dimer interface [polypeptide binding]; other site
318586000342	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
318586000343	Synaptic Flat tetramer interface [polypeptide binding]; other site
318586000344	Synaptic Site I dimer interface [polypeptide binding]; other site
318586000345	DNA binding site [nucleotide binding]
318586000346	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
318586000347	Predicted acetyltransferase [General function prediction only]; Region: COG2388
318586000348	Conjugal transfer protein TraD; Region: TraD; pfam06412
318586000349	Conjugal transfer protein TraD; Region: TraD; pfam06412
318586000350	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
318586000351	MobA/MobL family; Region: MobA_MobL; pfam03389
318586000352	AAA domain; Region: AAA_30; pfam13604
318586000353	Family description; Region: UvrD_C_2; pfam13538
318586000354	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
318586000355	PIN domain; Region: PIN_3; pfam13470
318586000356	HicB family; Region: HicB; pfam05534
318586000357	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586000358	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
318586000359	catalytic residues [active]
318586000360	catalytic nucleophile [active]
318586000361	Recombinase; Region: Recombinase; pfam07508
318586000362	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
318586000363	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586000364	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
318586000365	catalytic residues [active]
318586000366	catalytic nucleophile [active]
318586000367	Recombinase; Region: Recombinase; pfam07508
318586000368	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
318586000369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586000370	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586000371	active site
318586000372	catalytic tetrad [active]
318586000373	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
318586000374	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586000375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586000376	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
318586000377	active site
318586000378	NTP binding site [chemical binding]; other site
318586000379	metal binding triad [ion binding]; metal-binding site
318586000380	TIR domain; Region: TIR_2; pfam13676
318586000381	Bacterial SH3 domain; Region: SH3_3; pfam08239
318586000382	hypothetical protein; Provisional; Region: PRK10396
318586000383	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
318586000384	SEC-C motif; Region: SEC-C; pfam02810
318586000385	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
318586000386	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
318586000387	trimer interface [polypeptide binding]; other site
318586000388	active site
318586000389	substrate binding site [chemical binding]; other site
318586000390	CoA binding site [chemical binding]; other site
318586000391	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
318586000392	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
318586000393	DNA methylase; Region: N6_N4_Mtase; cl17433
318586000394	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
318586000395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586000396	Coenzyme A binding pocket [chemical binding]; other site
318586000397	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
318586000398	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
318586000399	dimer interface [polypeptide binding]; other site
318586000400	ssDNA binding site [nucleotide binding]; other site
318586000401	tetramer (dimer of dimers) interface [polypeptide binding]; other site
318586000402	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
318586000403	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
318586000404	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586000405	non-specific DNA binding site [nucleotide binding]; other site
318586000406	sequence-specific DNA binding site [nucleotide binding]; other site
318586000407	salt bridge; other site
318586000408	Helix-turn-helix domain; Region: HTH_17; pfam12728
318586000409	Replication initiator protein A; Region: RPA; pfam10134
318586000410	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
318586000411	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586000412	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
318586000413	cofactor binding site; other site
318586000414	substrate interaction site [chemical binding]; other site
318586000415	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586000416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586000417	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586000418	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
318586000419	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
318586000420	Protein of unknown function (DUF736); Region: DUF736; pfam05284
318586000421	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586000422	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586000423	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586000424	catalytic residue [active]
318586000425	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
318586000426	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
318586000427	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
318586000428	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
318586000429	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
318586000430	Walker A motif; other site
318586000431	ATP binding site [chemical binding]; other site
318586000432	Walker B motif; other site
318586000433	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
318586000434	Predicted transcriptional regulator [Transcription]; Region: COG3905
318586000435	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
318586000436	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
318586000437	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
318586000438	VirB7 interaction site; other site
318586000439	conjugal transfer protein TrbF; Provisional; Region: PRK13872
318586000440	conjugal transfer protein TrbL; Provisional; Region: PRK13875
318586000441	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
318586000442	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
318586000443	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
318586000444	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
318586000445	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
318586000446	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
318586000447	Walker A motif; other site
318586000448	ATP binding site [chemical binding]; other site
318586000449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586000450	Walker B; other site
318586000451	D-loop; other site
318586000452	H-loop/switch region; other site
318586000453	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
318586000454	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
318586000455	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
318586000456	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
318586000457	Walker A motif; other site
318586000458	ATP binding site [chemical binding]; other site
318586000459	Walker B motif; other site
318586000460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586000461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000462	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
318586000463	dimerization interface [polypeptide binding]; other site
318586000464	substrate binding pocket [chemical binding]; other site
318586000465	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586000466	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
318586000467	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
318586000468	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586000469	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586000470	MltA-interacting protein MipA; Region: MipA; cl01504
318586000471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586000472	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586000473	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586000474	dimerization interface [polypeptide binding]; other site
318586000475	putative DNA binding site [nucleotide binding]; other site
318586000476	putative Zn2+ binding site [ion binding]; other site
318586000477	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
318586000478	Cupin domain; Region: Cupin_2; pfam07883
318586000479	Cupin domain; Region: Cupin_2; cl17218
318586000480	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
318586000481	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
318586000482	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
318586000483	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586000484	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586000485	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586000486	active site
318586000487	hypothetical protein; Provisional; Region: PRK06847
318586000488	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586000489	hypothetical protein; Provisional; Region: PRK07236
318586000490	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586000491	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
318586000492	acyl-activating enzyme (AAE) consensus motif; other site
318586000493	AMP binding site [chemical binding]; other site
318586000494	active site
318586000495	CoA binding site [chemical binding]; other site
318586000496	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
318586000497	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
318586000498	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
318586000499	maleylacetoacetate isomerase; Region: maiA; TIGR01262
318586000500	C-terminal domain interface [polypeptide binding]; other site
318586000501	GSH binding site (G-site) [chemical binding]; other site
318586000502	putative dimer interface [polypeptide binding]; other site
318586000503	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
318586000504	dimer interface [polypeptide binding]; other site
318586000505	N-terminal domain interface [polypeptide binding]; other site
318586000506	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
318586000507	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586000508	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
318586000509	putative ligand binding site [chemical binding]; other site
318586000510	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586000511	TM-ABC transporter signature motif; other site
318586000512	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586000513	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586000514	TM-ABC transporter signature motif; other site
318586000515	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586000516	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586000517	Walker A/P-loop; other site
318586000518	ATP binding site [chemical binding]; other site
318586000519	Q-loop/lid; other site
318586000520	ABC transporter signature motif; other site
318586000521	Walker B; other site
318586000522	D-loop; other site
318586000523	H-loop/switch region; other site
318586000524	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586000525	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586000526	Walker A/P-loop; other site
318586000527	ATP binding site [chemical binding]; other site
318586000528	Q-loop/lid; other site
318586000529	ABC transporter signature motif; other site
318586000530	Walker B; other site
318586000531	D-loop; other site
318586000532	H-loop/switch region; other site
318586000533	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586000534	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
318586000535	NAD(P) binding site [chemical binding]; other site
318586000536	catalytic residues [active]
318586000537	choline dehydrogenase; Validated; Region: PRK02106
318586000538	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586000539	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
318586000540	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
318586000541	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586000542	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
318586000543	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
318586000544	metal binding site [ion binding]; metal-binding site
318586000545	putative dimer interface [polypeptide binding]; other site
318586000546	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586000547	MarR family; Region: MarR_2; pfam12802
318586000548	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586000549	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
318586000550	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586000551	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
318586000552	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
318586000553	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
318586000554	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
318586000555	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586000556	active site
318586000557	metal binding site [ion binding]; metal-binding site
318586000558	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
318586000559	classical (c) SDRs; Region: SDR_c; cd05233
318586000560	NAD(P) binding site [chemical binding]; other site
318586000561	active site
318586000562	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
318586000563	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586000564	Uncharacterized conserved protein [Function unknown]; Region: COG3777
318586000565	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586000566	active site 2 [active]
318586000567	active site 1 [active]
318586000568	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586000569	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586000570	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586000571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586000572	NAD(P) binding site [chemical binding]; other site
318586000573	active site
318586000574	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
318586000575	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586000576	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586000577	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586000578	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586000579	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586000580	active site
318586000581	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586000582	substrate binding site [chemical binding]; other site
318586000583	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
318586000584	oxyanion hole (OAH) forming residues; other site
318586000585	trimer interface [polypeptide binding]; other site
318586000586	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586000587	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586000588	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586000589	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
318586000590	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586000591	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
318586000592	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
318586000593	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
318586000594	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586000595	classical (c) SDRs; Region: SDR_c; cd05233
318586000596	NAD(P) binding site [chemical binding]; other site
318586000597	active site
318586000598	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
318586000599	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
318586000600	active site 1 [active]
318586000601	dimer interface [polypeptide binding]; other site
318586000602	hexamer interface [polypeptide binding]; other site
318586000603	active site 2 [active]
318586000604	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586000605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000606	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
318586000607	putative effector binding pocket; other site
318586000608	putative dimerization interface [polypeptide binding]; other site
318586000609	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
318586000610	DNA binding residues [nucleotide binding]
318586000611	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
318586000612	dimer interface [polypeptide binding]; other site
318586000613	putative metal binding site [ion binding]; other site
318586000614	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
318586000615	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
318586000616	metal-binding site [ion binding]
318586000617	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586000618	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586000619	motif II; other site
318586000620	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
318586000621	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
318586000622	arsenical-resistance protein; Region: acr3; TIGR00832
318586000623	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
318586000624	ArsC family; Region: ArsC; pfam03960
318586000625	catalytic residues [active]
318586000626	Low molecular weight phosphatase family; Region: LMWPc; cl00105
318586000627	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
318586000628	active site
318586000629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586000630	dimerization interface [polypeptide binding]; other site
318586000631	putative DNA binding site [nucleotide binding]; other site
318586000632	putative Zn2+ binding site [ion binding]; other site
318586000633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000634	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
318586000635	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586000636	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
318586000637	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586000638	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586000639	active site 2 [active]
318586000640	active site 1 [active]
318586000641	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586000642	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586000643	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586000644	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
318586000645	tetramerization interface [polypeptide binding]; other site
318586000646	NAD(P) binding site [chemical binding]; other site
318586000647	catalytic residues [active]
318586000648	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
318586000649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586000650	Walker A motif; other site
318586000651	ATP binding site [chemical binding]; other site
318586000652	Walker B motif; other site
318586000653	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
318586000654	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
318586000655	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586000656	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
318586000657	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586000658	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
318586000659	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
318586000660	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
318586000661	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586000662	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586000663	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000664	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
318586000665	putative effector binding pocket; other site
318586000666	putative dimerization interface [polypeptide binding]; other site
318586000667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586000668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586000669	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
318586000670	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
318586000671	Fusaric acid resistance protein family; Region: FUSC; pfam04632
318586000672	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
318586000673	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
318586000674	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586000675	Walker A/P-loop; other site
318586000676	ATP binding site [chemical binding]; other site
318586000677	Q-loop/lid; other site
318586000678	ABC transporter signature motif; other site
318586000679	Walker B; other site
318586000680	D-loop; other site
318586000681	H-loop/switch region; other site
318586000682	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
318586000683	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
318586000684	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586000685	Walker A/P-loop; other site
318586000686	ATP binding site [chemical binding]; other site
318586000687	Q-loop/lid; other site
318586000688	ABC transporter signature motif; other site
318586000689	Walker B; other site
318586000690	D-loop; other site
318586000691	H-loop/switch region; other site
318586000692	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
318586000693	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586000694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586000695	dimer interface [polypeptide binding]; other site
318586000696	conserved gate region; other site
318586000697	putative PBP binding loops; other site
318586000698	ABC-ATPase subunit interface; other site
318586000699	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586000700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586000701	dimer interface [polypeptide binding]; other site
318586000702	conserved gate region; other site
318586000703	ABC-ATPase subunit interface; other site
318586000704	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_1; cd08508
318586000705	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
318586000706	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586000707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586000708	DNA-binding site [nucleotide binding]; DNA binding site
318586000709	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
318586000710	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
318586000711	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
318586000712	6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191
318586000713	putative active site [active]
318586000714	metal binding site [ion binding]; metal-binding site
318586000715	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586000716	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
318586000717	tetramerization interface [polypeptide binding]; other site
318586000718	NAD(P) binding site [chemical binding]; other site
318586000719	catalytic residues [active]
318586000720	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
318586000721	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
318586000722	active site pocket [active]
318586000723	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
318586000724	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
318586000725	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
318586000726	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
318586000727	Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320
318586000728	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
318586000729	ligand binding site [chemical binding]; other site
318586000730	dimerization interface [polypeptide binding]; other site
318586000731	zinc binding site [ion binding]; other site
318586000732	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
318586000733	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586000734	Walker A/P-loop; other site
318586000735	ATP binding site [chemical binding]; other site
318586000736	Q-loop/lid; other site
318586000737	ABC transporter signature motif; other site
318586000738	Walker B; other site
318586000739	D-loop; other site
318586000740	H-loop/switch region; other site
318586000741	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586000742	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586000743	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586000744	TM-ABC transporter signature motif; other site
318586000745	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
318586000746	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
318586000747	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
318586000748	putative active site [active]
318586000749	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586000750	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
318586000751	substrate binding site [chemical binding]; other site
318586000752	dimer interface [polypeptide binding]; other site
318586000753	ATP binding site [chemical binding]; other site
318586000754	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
318586000755	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
318586000756	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
318586000757	HNH endonuclease; Region: HNH_3; pfam13392
318586000758	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
318586000759	DNA-binding interface [nucleotide binding]; DNA binding site
318586000760	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
318586000761	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586000762	cofactor binding site; other site
318586000763	DNA binding site [nucleotide binding]
318586000764	substrate interaction site [chemical binding]; other site
318586000765	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586000766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
318586000767	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
318586000768	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
318586000769	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586000770	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
318586000771	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
318586000772	Putative phage tail protein; Region: Phage-tail_3; pfam13550
318586000773	NlpC/P60 family; Region: NLPC_P60; cl17555
318586000774	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
318586000775	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
318586000776	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
318586000777	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
318586000778	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
318586000779	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
318586000780	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586000781	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
318586000782	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
318586000783	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
318586000784	putative active site pocket [active]
318586000785	dimerization interface [polypeptide binding]; other site
318586000786	putative catalytic residue [active]
318586000787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586000788	benzoate transport; Region: 2A0115; TIGR00895
318586000789	putative substrate translocation pore; other site
318586000790	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
318586000791	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586000792	DNA-binding site [nucleotide binding]; DNA binding site
318586000793	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586000794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586000795	homodimer interface [polypeptide binding]; other site
318586000796	catalytic residue [active]
318586000797	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
318586000798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586000799	Walker A/P-loop; other site
318586000800	ATP binding site [chemical binding]; other site
318586000801	Q-loop/lid; other site
318586000802	ABC transporter signature motif; other site
318586000803	Walker B; other site
318586000804	D-loop; other site
318586000805	H-loop/switch region; other site
318586000806	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
318586000807	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586000808	substrate binding pocket [chemical binding]; other site
318586000809	membrane-bound complex binding site; other site
318586000810	hinge residues; other site
318586000811	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586000812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586000813	dimer interface [polypeptide binding]; other site
318586000814	conserved gate region; other site
318586000815	putative PBP binding loops; other site
318586000816	ABC-ATPase subunit interface; other site
318586000817	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586000818	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586000819	dimer interface [polypeptide binding]; other site
318586000820	conserved gate region; other site
318586000821	putative PBP binding loops; other site
318586000822	ABC-ATPase subunit interface; other site
318586000823	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
318586000824	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
318586000825	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
318586000826	tetramer interface [polypeptide binding]; other site
318586000827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586000828	catalytic residue [active]
318586000829	ectoine utilization protein EutC; Validated; Region: PRK08291
318586000830	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
318586000831	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
318586000832	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586000833	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
318586000834	active site
318586000835	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
318586000836	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
318586000837	putative active site [active]
318586000838	Zn binding site [ion binding]; other site
318586000839	succinic semialdehyde dehydrogenase; Region: PLN02278
318586000840	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
318586000841	tetramerization interface [polypeptide binding]; other site
318586000842	NAD(P) binding site [chemical binding]; other site
318586000843	catalytic residues [active]
318586000844	hypothetical protein; Provisional; Region: PRK07482
318586000845	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586000846	inhibitor-cofactor binding pocket; inhibition site
318586000847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586000848	catalytic residue [active]
318586000849	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
318586000850	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
318586000851	putative NAD(P) binding site [chemical binding]; other site
318586000852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
318586000853	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
318586000854	Hint domain; Region: Hint_2; pfam13403
318586000855	MarR family; Region: MarR_2; cl17246
318586000856	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586000857	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
318586000858	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
318586000859	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
318586000860	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586000861	Walker A/P-loop; other site
318586000862	ATP binding site [chemical binding]; other site
318586000863	Q-loop/lid; other site
318586000864	ABC transporter signature motif; other site
318586000865	Walker B; other site
318586000866	D-loop; other site
318586000867	H-loop/switch region; other site
318586000868	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586000869	ABC-ATPase subunit  interface; other site
318586000870	dimer interface [polypeptide binding]; other site
318586000871	putative PBP binding regions; other site
318586000872	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586000873	ABC-ATPase subunit  interface; other site
318586000874	dimer interface [polypeptide binding]; other site
318586000875	putative PBP binding regions; other site
318586000876	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
318586000877	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
318586000878	putative ligand binding residues [chemical binding]; other site
318586000879	selenocysteine synthase; Provisional; Region: PRK04311
318586000880	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
318586000881	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
318586000882	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586000883	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000884	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586000885	dimerization interface [polypeptide binding]; other site
318586000886	Predicted membrane protein [Function unknown]; Region: COG4125
318586000887	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
318586000888	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
318586000889	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586000890	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000891	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
318586000892	dimerization interface [polypeptide binding]; other site
318586000893	substrate binding pocket [chemical binding]; other site
318586000894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
318586000895	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
318586000896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
318586000897	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586000898	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586000899	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586000900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586000901	active site
318586000902	phosphorylation site [posttranslational modification]
318586000903	intermolecular recognition site; other site
318586000904	dimerization interface [polypeptide binding]; other site
318586000905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586000906	DNA binding site [nucleotide binding]
318586000907	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
318586000908	sensor protein QseC; Provisional; Region: PRK10337
318586000909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586000910	ATP binding site [chemical binding]; other site
318586000911	Mg2+ binding site [ion binding]; other site
318586000912	G-X-G motif; other site
318586000913	hypothetical protein; Provisional; Region: PRK14013
318586000914	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
318586000915	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586000916	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586000917	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586000918	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586000919	NAD(P) binding site [chemical binding]; other site
318586000920	active site
318586000921	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
318586000922	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
318586000923	active site
318586000924	HPP family; Region: HPP; pfam04982
318586000925	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
318586000926	FOG: CBS domain [General function prediction only]; Region: COG0517
318586000927	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
318586000928	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586000929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586000930	DNA-binding site [nucleotide binding]; DNA binding site
318586000931	FCD domain; Region: FCD; pfam07729
318586000932	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
318586000933	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
318586000934	putative active site [active]
318586000935	hypothetical protein; Provisional; Region: PRK05463
318586000936	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
318586000937	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
318586000938	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
318586000939	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
318586000940	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586000941	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
318586000942	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
318586000943	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
318586000944	carboxyltransferase (CT) interaction site; other site
318586000945	biotinylation site [posttranslational modification]; other site
318586000946	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
318586000947	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
318586000948	HutD; Region: HutD; pfam05962
318586000949	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
318586000950	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
318586000951	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586000952	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586000953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586000954	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
318586000955	putative effector binding pocket; other site
318586000956	dimerization interface [polypeptide binding]; other site
318586000957	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
318586000958	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586000959	Zn binding site [ion binding]; other site
318586000960	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
318586000961	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586000962	Zn binding site [ion binding]; other site
318586000963	Uncharacterized conserved protein [Function unknown]; Region: COG5649
318586000964	Predicted flavoprotein [General function prediction only]; Region: COG0431
318586000965	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586000966	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
318586000967	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586000968	Zn binding site [ion binding]; other site
318586000969	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
318586000970	Zn binding site [ion binding]; other site
318586000971	Predicted esterase [General function prediction only]; Region: COG0400
318586000972	putative hydrolase; Provisional; Region: PRK11460
318586000973	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
318586000974	glutathionine S-transferase; Provisional; Region: PRK10542
318586000975	C-terminal domain interface [polypeptide binding]; other site
318586000976	GSH binding site (G-site) [chemical binding]; other site
318586000977	dimer interface [polypeptide binding]; other site
318586000978	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
318586000979	dimer interface [polypeptide binding]; other site
318586000980	N-terminal domain interface [polypeptide binding]; other site
318586000981	substrate binding pocket (H-site) [chemical binding]; other site
318586000982	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
318586000983	substrate binding site [chemical binding]; other site
318586000984	active site
318586000985	catalytic residues [active]
318586000986	heterodimer interface [polypeptide binding]; other site
318586000987	GTP-binding protein YchF; Reviewed; Region: PRK09601
318586000988	YchF GTPase; Region: YchF; cd01900
318586000989	G1 box; other site
318586000990	GTP/Mg2+ binding site [chemical binding]; other site
318586000991	Switch I region; other site
318586000992	G2 box; other site
318586000993	Switch II region; other site
318586000994	G3 box; other site
318586000995	G4 box; other site
318586000996	G5 box; other site
318586000997	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
318586000998	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586000999	active site
318586001000	catalytic residues [active]
318586001001	DNA binding site [nucleotide binding]
318586001002	Int/Topo IB signature motif; other site
318586001003	DNA methylase; Region: N6_N4_Mtase; cl17433
318586001004	DNA polymerase III subunit beta; Validated; Region: PRK05643
318586001005	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
318586001006	putative DNA binding surface [nucleotide binding]; other site
318586001007	dimer interface [polypeptide binding]; other site
318586001008	beta-clamp/clamp loader binding surface; other site
318586001009	beta-clamp/translesion DNA polymerase binding surface; other site
318586001010	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
318586001011	D5 N terminal like; Region: D5_N; smart00885
318586001012	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
318586001013	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
318586001014	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586001015	active site
318586001016	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
318586001017	DNA-binding interface [nucleotide binding]; DNA binding site
318586001018	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
318586001019	Phage portal protein; Region: Phage_portal; pfam04860
318586001020	Phage-related protein [Function unknown]; Region: COG4695; cl01923
318586001021	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
318586001022	oligomer interface [polypeptide binding]; other site
318586001023	active site residues [active]
318586001024	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
318586001025	Phage capsid family; Region: Phage_capsid; pfam05065
318586001026	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
318586001027	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
318586001028	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
318586001029	Phage major tail protein 2; Region: Phage_tail_2; cl11463
318586001030	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
318586001031	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
318586001032	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
318586001033	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
318586001034	substrate binding site [chemical binding]; other site
318586001035	CheD chemotactic sensory transduction; Region: CheD; cl00810
318586001036	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586001037	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
318586001038	catalytic residues [active]
318586001039	catalytic nucleophile [active]
318586001040	Presynaptic Site I dimer interface [polypeptide binding]; other site
318586001041	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
318586001042	Synaptic Flat tetramer interface [polypeptide binding]; other site
318586001043	Synaptic Site I dimer interface [polypeptide binding]; other site
318586001044	DNA binding site [nucleotide binding]
318586001045	Recombinase; Region: Recombinase; pfam07508
318586001046	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
318586001047	Protein of unknown function (DUF983); Region: DUF983; cl02211
318586001048	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
318586001049	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
318586001050	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
318586001051	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
318586001052	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
318586001053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586001054	FeS/SAM binding site; other site
318586001055	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
318586001056	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
318586001057	putative active site [active]
318586001058	Zn binding site [ion binding]; other site
318586001059	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
318586001060	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
318586001061	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
318586001062	substrate binding pocket [chemical binding]; other site
318586001063	chain length determination region; other site
318586001064	substrate-Mg2+ binding site; other site
318586001065	catalytic residues [active]
318586001066	aspartate-rich region 1; other site
318586001067	active site lid residues [active]
318586001068	aspartate-rich region 2; other site
318586001069	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
318586001070	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
318586001071	TPP-binding site; other site
318586001072	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
318586001073	PYR/PP interface [polypeptide binding]; other site
318586001074	dimer interface [polypeptide binding]; other site
318586001075	TPP binding site [chemical binding]; other site
318586001076	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586001077	Bacterial SH3 domain; Region: SH3_3; pfam08239
318586001078	Predicted membrane protein [Function unknown]; Region: COG3650
318586001079	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586001080	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
318586001081	putative NAD(P) binding site [chemical binding]; other site
318586001082	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586001083	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
318586001084	AMP nucleosidase; Provisional; Region: PRK08292
318586001085	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
318586001086	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
318586001087	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
318586001088	IHF dimer interface [polypeptide binding]; other site
318586001089	IHF - DNA interface [nucleotide binding]; other site
318586001090	EamA-like transporter family; Region: EamA; pfam00892
318586001091	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
318586001092	EamA-like transporter family; Region: EamA; pfam00892
318586001093	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586001094	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
318586001095	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
318586001096	dimer interface [polypeptide binding]; other site
318586001097	N-terminal domain interface [polypeptide binding]; other site
318586001098	putative substrate binding pocket (H-site) [chemical binding]; other site
318586001099	Predicted transcriptional regulator [Transcription]; Region: COG2378
318586001100	HTH domain; Region: HTH_11; pfam08279
318586001101	WYL domain; Region: WYL; pfam13280
318586001102	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
318586001103	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
318586001104	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586001105	catalytic residue [active]
318586001106	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586001107	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586001108	putative DNA binding site [nucleotide binding]; other site
318586001109	putative Zn2+ binding site [ion binding]; other site
318586001110	AsnC family; Region: AsnC_trans_reg; pfam01037
318586001111	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
318586001112	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
318586001113	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
318586001114	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
318586001115	active site
318586001116	DNA binding site [nucleotide binding]
318586001117	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
318586001118	DNA binding site [nucleotide binding]
318586001119	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
318586001120	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586001121	ATP binding site [chemical binding]; other site
318586001122	putative Mg++ binding site [ion binding]; other site
318586001123	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586001124	nucleotide binding region [chemical binding]; other site
318586001125	ATP-binding site [chemical binding]; other site
318586001126	DEAD/H associated; Region: DEAD_assoc; pfam08494
318586001127	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
318586001128	putative active site [active]
318586001129	putative metal binding site [ion binding]; other site
318586001130	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
318586001131	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
318586001132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586001133	Mg2+ binding site [ion binding]; other site
318586001134	G-X-G motif; other site
318586001135	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
318586001136	anchoring element; other site
318586001137	dimer interface [polypeptide binding]; other site
318586001138	ATP binding site [chemical binding]; other site
318586001139	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
318586001140	active site
318586001141	putative metal-binding site [ion binding]; other site
318586001142	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
318586001143	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
318586001144	GTPase Era; Reviewed; Region: era; PRK00089
318586001145	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
318586001146	G1 box; other site
318586001147	GTP/Mg2+ binding site [chemical binding]; other site
318586001148	Switch I region; other site
318586001149	G2 box; other site
318586001150	Switch II region; other site
318586001151	G3 box; other site
318586001152	G4 box; other site
318586001153	G5 box; other site
318586001154	KH domain; Region: KH_2; pfam07650
318586001155	G-X-X-G motif; other site
318586001156	ribonuclease III; Reviewed; Region: rnc; PRK00102
318586001157	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
318586001158	dimerization interface [polypeptide binding]; other site
318586001159	active site
318586001160	metal binding site [ion binding]; metal-binding site
318586001161	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
318586001162	dsRNA binding site [nucleotide binding]; other site
318586001163	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
318586001164	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
318586001165	Catalytic site [active]
318586001166	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
318586001167	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
318586001168	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
318586001169	active site
318586001170	hydrophilic channel; other site
318586001171	dimerization interface [polypeptide binding]; other site
318586001172	catalytic residues [active]
318586001173	active site lid [active]
318586001174	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
318586001175	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
318586001176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586001177	TPR repeat; Region: TPR_11; pfam13414
318586001178	binding surface
318586001179	TPR motif; other site
318586001180	TPR repeat; Region: TPR_11; pfam13414
318586001181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586001182	binding surface
318586001183	TPR motif; other site
318586001184	TPR repeat; Region: TPR_11; pfam13414
318586001185	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
318586001186	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586001187	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
318586001188	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
318586001189	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
318586001190	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
318586001191	AzlC protein; Region: AzlC; pfam03591
318586001192	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
318586001193	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
318586001194	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
318586001195	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586001196	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586001197	active site
318586001198	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
318586001199	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
318586001200	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
318586001201	hypothetical protein; Validated; Region: PRK00228
318586001202	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
318586001203	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
318586001204	Fe-S cluster binding site [ion binding]; other site
318586001205	active site
318586001206	tartrate dehydrogenase; Region: TTC; TIGR02089
318586001207	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
318586001208	EamA-like transporter family; Region: EamA; pfam00892
318586001209	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586001210	Domain of unknown function (DUF955); Region: DUF955; pfam06114
318586001211	Beta protein; Region: Beta_protein; pfam14350
318586001212	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
318586001213	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586001214	CHC2 zinc finger; Region: zf-CHC2; cl17510
318586001215	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
318586001216	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
318586001217	active site
318586001218	metal binding site [ion binding]; metal-binding site
318586001219	interdomain interaction site; other site
318586001220	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
318586001221	putative active site [active]
318586001222	putative NTP binding site [chemical binding]; other site
318586001223	putative nucleic acid binding site [nucleotide binding]; other site
318586001224	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
318586001225	active site
318586001226	catalytic triad [active]
318586001227	dimer interface [polypeptide binding]; other site
318586001228	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
318586001229	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
318586001230	active site
318586001231	catalytic site [active]
318586001232	substrate binding site [chemical binding]; other site
318586001233	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
318586001234	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586001235	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586001236	non-specific DNA binding site [nucleotide binding]; other site
318586001237	salt bridge; other site
318586001238	sequence-specific DNA binding site [nucleotide binding]; other site
318586001239	Integrase core domain; Region: rve; pfam00665
318586001240	AAA ATPase domain; Region: AAA_16; pfam13191
318586001241	AAA domain; Region: AAA_22; pfam13401
318586001242	TniQ; Region: TniQ; pfam06527
318586001243	Integrase core domain; Region: rve; pfam00665
318586001244	transposase; Validated; Region: PRK08181
318586001245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586001246	Walker A motif; other site
318586001247	ATP binding site [chemical binding]; other site
318586001248	Recombinase; Region: Recombinase; pfam07508
318586001249	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586001250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586001251	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586001252	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586001253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586001254	Walker A/P-loop; other site
318586001255	ATP binding site [chemical binding]; other site
318586001256	Q-loop/lid; other site
318586001257	ABC transporter signature motif; other site
318586001258	Walker B; other site
318586001259	D-loop; other site
318586001260	H-loop/switch region; other site
318586001261	TOBE domain; Region: TOBE_2; pfam08402
318586001262	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586001263	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586001264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586001265	dimer interface [polypeptide binding]; other site
318586001266	conserved gate region; other site
318586001267	putative PBP binding loops; other site
318586001268	ABC-ATPase subunit interface; other site
318586001269	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586001270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586001271	dimer interface [polypeptide binding]; other site
318586001272	conserved gate region; other site
318586001273	putative PBP binding loops; other site
318586001274	ABC-ATPase subunit interface; other site
318586001275	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586001276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586001277	DNA-binding site [nucleotide binding]; DNA binding site
318586001278	FCD domain; Region: FCD; pfam07729
318586001279	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
318586001280	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
318586001281	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
318586001282	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
318586001283	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
318586001284	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
318586001285	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
318586001286	classical (c) SDRs; Region: SDR_c; cd05233
318586001287	NAD(P) binding site [chemical binding]; other site
318586001288	active site
318586001289	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586001290	active site
318586001291	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
318586001292	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586001293	non-specific DNA binding site [nucleotide binding]; other site
318586001294	salt bridge; other site
318586001295	sequence-specific DNA binding site [nucleotide binding]; other site
318586001296	Cupin domain; Region: Cupin_2; pfam07883
318586001297	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
318586001298	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
318586001299	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586001300	classical (c) SDRs; Region: SDR_c; cd05233
318586001301	NAD(P) binding site [chemical binding]; other site
318586001302	active site
318586001303	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
318586001304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586001305	putative substrate translocation pore; other site
318586001306	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
318586001307	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
318586001308	oligomeric interface; other site
318586001309	putative active site [active]
318586001310	homodimer interface [polypeptide binding]; other site
318586001311	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586001312	non-specific DNA binding site [nucleotide binding]; other site
318586001313	salt bridge; other site
318586001314	sequence-specific DNA binding site [nucleotide binding]; other site
318586001315	Predicted transcriptional regulator [Transcription]; Region: COG4190
318586001316	MarR family; Region: MarR_2; pfam12802
318586001317	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
318586001318	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
318586001319	active site
318586001320	dimer interface [polypeptide binding]; other site
318586001321	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
318586001322	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
318586001323	active site
318586001324	FMN binding site [chemical binding]; other site
318586001325	substrate binding site [chemical binding]; other site
318586001326	3Fe-4S cluster binding site [ion binding]; other site
318586001327	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
318586001328	domain interface; other site
318586001329	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
318586001330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586001331	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586001332	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
318586001333	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
318586001334	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
318586001335	putative NAD(P) binding site [chemical binding]; other site
318586001336	active site
318586001337	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
318586001338	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586001339	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
318586001340	nudix motif; other site
318586001341	Response regulator receiver domain; Region: Response_reg; pfam00072
318586001342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586001343	active site
318586001344	phosphorylation site [posttranslational modification]
318586001345	intermolecular recognition site; other site
318586001346	dimerization interface [polypeptide binding]; other site
318586001347	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
318586001348	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
318586001349	putative binding surface; other site
318586001350	active site
318586001351	threonine dehydratase; Validated; Region: PRK08639
318586001352	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
318586001353	tetramer interface [polypeptide binding]; other site
318586001354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586001355	catalytic residue [active]
318586001356	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
318586001357	putative Ile/Val binding site [chemical binding]; other site
318586001358	argininosuccinate synthase; Provisional; Region: PRK13820
318586001359	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
318586001360	ANP binding site [chemical binding]; other site
318586001361	Substrate Binding Site II [chemical binding]; other site
318586001362	Substrate Binding Site I [chemical binding]; other site
318586001363	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
318586001364	dimer interface [polypeptide binding]; other site
318586001365	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
318586001366	MPT binding site; other site
318586001367	trimer interface [polypeptide binding]; other site
318586001368	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
318586001369	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
318586001370	active site
318586001371	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586001372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586001373	Walker A/P-loop; other site
318586001374	ATP binding site [chemical binding]; other site
318586001375	Q-loop/lid; other site
318586001376	ABC transporter signature motif; other site
318586001377	Walker B; other site
318586001378	D-loop; other site
318586001379	H-loop/switch region; other site
318586001380	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586001381	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586001382	TM-ABC transporter signature motif; other site
318586001383	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
318586001384	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
318586001385	ligand binding site [chemical binding]; other site
318586001386	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586001387	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
318586001388	non-specific DNA interactions [nucleotide binding]; other site
318586001389	DNA binding site [nucleotide binding]
318586001390	sequence specific DNA binding site [nucleotide binding]; other site
318586001391	putative cAMP binding site [chemical binding]; other site
318586001392	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
318586001393	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
318586001394	chaperone protein DnaJ; Provisional; Region: PRK14299
318586001395	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
318586001396	HSP70 interaction site [polypeptide binding]; other site
318586001397	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
318586001398	substrate binding site [polypeptide binding]; other site
318586001399	dimer interface [polypeptide binding]; other site
318586001400	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
318586001401	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
318586001402	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
318586001403	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
318586001404	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
318586001405	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586001406	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
318586001407	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
318586001408	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
318586001409	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
318586001410	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
318586001411	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
318586001412	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
318586001413	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
318586001414	Protein of unknown function (DUF461); Region: DUF461; pfam04314
318586001415	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
318586001416	active site
318586001417	catalytic triad [active]
318586001418	oxyanion hole [active]
318586001419	switch loop; other site
318586001420	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
318586001421	metal-binding site [ion binding]
318586001422	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
318586001423	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
318586001424	metal-binding site [ion binding]
318586001425	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586001426	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
318586001427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
318586001428	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586001429	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
318586001430	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
318586001431	active site residue [active]
318586001432	purine nucleoside phosphorylase; Provisional; Region: PRK08202
318586001433	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586001434	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
318586001435	TM-ABC transporter signature motif; other site
318586001436	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
318586001437	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586001438	TM-ABC transporter signature motif; other site
318586001439	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
318586001440	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586001441	Walker A/P-loop; other site
318586001442	ATP binding site [chemical binding]; other site
318586001443	Q-loop/lid; other site
318586001444	ABC transporter signature motif; other site
318586001445	Walker B; other site
318586001446	D-loop; other site
318586001447	H-loop/switch region; other site
318586001448	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586001449	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
318586001450	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
318586001451	ligand binding site [chemical binding]; other site
318586001452	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
318586001453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586001454	Coenzyme A binding pocket [chemical binding]; other site
318586001455	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
318586001456	Glycoprotease family; Region: Peptidase_M22; pfam00814
318586001457	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
318586001458	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
318586001459	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
318586001460	Ligand Binding Site [chemical binding]; other site
318586001461	Bacterial sugar transferase; Region: Bac_transf; pfam02397
318586001462	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
318586001463	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
318586001464	dimerization interface 3.5A [polypeptide binding]; other site
318586001465	active site
318586001466	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
318586001467	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
318586001468	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586001469	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
318586001470	dimer interface [polypeptide binding]; other site
318586001471	motif 1; other site
318586001472	active site
318586001473	motif 2; other site
318586001474	motif 3; other site
318586001475	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
318586001476	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
318586001477	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
318586001478	pyruvate phosphate dikinase; Provisional; Region: PRK09279
318586001479	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
318586001480	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
318586001481	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
318586001482	Dihydroneopterin aldolase; Region: FolB; pfam02152
318586001483	active site
318586001484	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
318586001485	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
318586001486	dihydropteroate synthase; Region: DHPS; TIGR01496
318586001487	substrate binding pocket [chemical binding]; other site
318586001488	dimer interface [polypeptide binding]; other site
318586001489	inhibitor binding site; inhibition site
318586001490	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
318586001491	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
318586001492	active site
318586001493	substrate binding site [chemical binding]; other site
318586001494	metal binding site [ion binding]; metal-binding site
318586001495	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586001496	salicylate hydroxylase; Provisional; Region: PRK08163
318586001497	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
318586001498	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
318586001499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586001500	Walker A motif; other site
318586001501	ATP binding site [chemical binding]; other site
318586001502	Walker B motif; other site
318586001503	arginine finger; other site
318586001504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586001505	Coenzyme A binding pocket [chemical binding]; other site
318586001506	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586001507	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586001508	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586001509	catalytic residue [active]
318586001510	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
318586001511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
318586001512	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586001513	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
318586001514	MAPEG family; Region: MAPEG; pfam01124
318586001515	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586001516	E3 interaction surface; other site
318586001517	lipoyl attachment site [posttranslational modification]; other site
318586001518	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
318586001519	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586001520	E3 interaction surface; other site
318586001521	lipoyl attachment site [posttranslational modification]; other site
318586001522	e3 binding domain; Region: E3_binding; pfam02817
318586001523	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
318586001524	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
318586001525	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
318586001526	TPP-binding site [chemical binding]; other site
318586001527	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
318586001528	dimer interface [polypeptide binding]; other site
318586001529	PYR/PP interface [polypeptide binding]; other site
318586001530	TPP binding site [chemical binding]; other site
318586001531	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
318586001532	CoA binding domain; Region: CoA_binding; pfam02629
318586001533	CoA-ligase; Region: Ligase_CoA; pfam00549
318586001534	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
318586001535	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
318586001536	CoA-ligase; Region: Ligase_CoA; pfam00549
318586001537	malate dehydrogenase; Reviewed; Region: PRK06223
318586001538	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
318586001539	NAD(P) binding site [chemical binding]; other site
318586001540	dimer interface [polypeptide binding]; other site
318586001541	tetramer (dimer of dimers) interface [polypeptide binding]; other site
318586001542	substrate binding site [chemical binding]; other site
318586001543	Predicted permeases [General function prediction only]; Region: COG0730
318586001544	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
318586001545	NnrU protein; Region: NnrU; pfam07298
318586001546	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
318586001547	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
318586001548	putative active site [active]
318586001549	putative catalytic site [active]
318586001550	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
318586001551	putative active site [active]
318586001552	putative catalytic site [active]
318586001553	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
318586001554	Iron-sulfur protein interface; other site
318586001555	proximal quinone binding site [chemical binding]; other site
318586001556	SdhD (CybS) interface [polypeptide binding]; other site
318586001557	proximal heme binding site [chemical binding]; other site
318586001558	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
318586001559	putative SdhC subunit interface [polypeptide binding]; other site
318586001560	putative proximal heme binding site [chemical binding]; other site
318586001561	putative Iron-sulfur protein interface [polypeptide binding]; other site
318586001562	putative proximal quinone binding site; other site
318586001563	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
318586001564	L-aspartate oxidase; Provisional; Region: PRK06175
318586001565	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
318586001566	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
318586001567	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586001568	catalytic loop [active]
318586001569	iron binding site [ion binding]; other site
318586001570	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
318586001571	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
318586001572	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
318586001573	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
318586001574	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
318586001575	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
318586001576	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
318586001577	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
318586001578	amidase catalytic site [active]
318586001579	Zn binding residues [ion binding]; other site
318586001580	substrate binding site [chemical binding]; other site
318586001581	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
318586001582	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
318586001583	Domain of unknown function DUF59; Region: DUF59; pfam01883
318586001584	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
318586001585	Walker A motif; other site
318586001586	cell division protein MraZ; Reviewed; Region: PRK00326
318586001587	MraZ protein; Region: MraZ; pfam02381
318586001588	MraZ protein; Region: MraZ; pfam02381
318586001589	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
318586001590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586001591	S-adenosylmethionine binding site [chemical binding]; other site
318586001592	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
318586001593	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
318586001594	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
318586001595	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
318586001596	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
318586001597	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
318586001598	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
318586001599	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
318586001600	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
318586001601	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
318586001602	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
318586001603	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
318586001604	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
318586001605	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
318586001606	Mg++ binding site [ion binding]; other site
318586001607	putative catalytic motif [active]
318586001608	putative substrate binding site [chemical binding]; other site
318586001609	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
318586001610	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
318586001611	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
318586001612	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
318586001613	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; Region: TDT_TehA_like; cd09322
318586001614	gating phenylalanine in ion channel; other site
318586001615	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
318586001616	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586001617	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
318586001618	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
318586001619	active site
318586001620	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586001621	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586001622	catalytic residue [active]
318586001623	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
318586001624	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
318586001625	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
318586001626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586001627	dimer interface [polypeptide binding]; other site
318586001628	phosphorylation site [posttranslational modification]
318586001629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586001630	ATP binding site [chemical binding]; other site
318586001631	Mg2+ binding site [ion binding]; other site
318586001632	G-X-G motif; other site
318586001633	Response regulator receiver domain; Region: Response_reg; pfam00072
318586001634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586001635	active site
318586001636	phosphorylation site [posttranslational modification]
318586001637	intermolecular recognition site; other site
318586001638	dimerization interface [polypeptide binding]; other site
318586001639	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
318586001640	recombinase A; Provisional; Region: recA; PRK09354
318586001641	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
318586001642	hexamer interface [polypeptide binding]; other site
318586001643	Walker A motif; other site
318586001644	ATP binding site [chemical binding]; other site
318586001645	Walker B motif; other site
318586001646	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
318586001647	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
318586001648	motif 1; other site
318586001649	active site
318586001650	motif 2; other site
318586001651	motif 3; other site
318586001652	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
318586001653	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
318586001654	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
318586001655	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
318586001656	putative active site [active]
318586001657	putative dimer interface [polypeptide binding]; other site
318586001658	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
318586001659	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
318586001660	GDP-binding site [chemical binding]; other site
318586001661	ACT binding site; other site
318586001662	IMP binding site; other site
318586001663	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
318586001664	Thiamine pyrophosphokinase; Region: TPK; cd07995
318586001665	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
318586001666	active site
318586001667	dimerization interface [polypeptide binding]; other site
318586001668	thiamine binding site [chemical binding]; other site
318586001669	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586001670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586001671	dimer interface [polypeptide binding]; other site
318586001672	conserved gate region; other site
318586001673	putative PBP binding loops; other site
318586001674	ABC-ATPase subunit interface; other site
318586001675	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586001676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586001677	dimer interface [polypeptide binding]; other site
318586001678	conserved gate region; other site
318586001679	putative PBP binding loops; other site
318586001680	ABC-ATPase subunit interface; other site
318586001681	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586001682	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
318586001683	peptide binding site [polypeptide binding]; other site
318586001684	dimer interface [polypeptide binding]; other site
318586001685	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586001686	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586001687	Walker A/P-loop; other site
318586001688	ATP binding site [chemical binding]; other site
318586001689	Q-loop/lid; other site
318586001690	ABC transporter signature motif; other site
318586001691	Walker B; other site
318586001692	D-loop; other site
318586001693	H-loop/switch region; other site
318586001694	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586001695	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586001696	Walker A/P-loop; other site
318586001697	ATP binding site [chemical binding]; other site
318586001698	Q-loop/lid; other site
318586001699	ABC transporter signature motif; other site
318586001700	Walker B; other site
318586001701	D-loop; other site
318586001702	H-loop/switch region; other site
318586001703	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
318586001704	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
318586001705	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
318586001706	metal binding site [ion binding]; metal-binding site
318586001707	putative dimer interface [polypeptide binding]; other site
318586001708	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
318586001709	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
318586001710	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586001711	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
318586001712	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
318586001713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586001714	putative substrate translocation pore; other site
318586001715	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586001716	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
318586001717	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
318586001718	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
318586001719	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
318586001720	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
318586001721	heme binding site [chemical binding]; other site
318586001722	ferroxidase pore; other site
318586001723	ferroxidase diiron center [ion binding]; other site
318586001724	phosphoglycolate phosphatase; Provisional; Region: PRK13222
318586001725	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
318586001726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586001727	motif II; other site
318586001728	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
318586001729	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
318586001730	Substrate binding site; other site
318586001731	Mg++ binding site; other site
318586001732	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
318586001733	active site
318586001734	substrate binding site [chemical binding]; other site
318586001735	CoA binding site [chemical binding]; other site
318586001736	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
318586001737	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
318586001738	glutaminase active site [active]
318586001739	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
318586001740	dimer interface [polypeptide binding]; other site
318586001741	active site
318586001742	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
318586001743	dimer interface [polypeptide binding]; other site
318586001744	active site
318586001745	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
318586001746	putative active site pocket [active]
318586001747	cleavage site
318586001748	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
318586001749	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
318586001750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586001751	S-adenosylmethionine binding site [chemical binding]; other site
318586001752	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
318586001753	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
318586001754	RNA methyltransferase, RsmE family; Region: TIGR00046
318586001755	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
318586001756	UbiA prenyltransferase family; Region: UbiA; pfam01040
318586001757	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
318586001758	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586001759	ligand binding site [chemical binding]; other site
318586001760	tellurium resistance terB-like protein; Region: terB_like; cd07177
318586001761	metal binding site [ion binding]; metal-binding site
318586001762	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
318586001763	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586001764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586001765	homodimer interface [polypeptide binding]; other site
318586001766	catalytic residue [active]
318586001767	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
318586001768	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
318586001769	active site residue [active]
318586001770	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
318586001771	active site residue [active]
318586001772	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
318586001773	SmpB-tmRNA interface; other site
318586001774	thiamine pyrophosphate protein; Validated; Region: PRK08199
318586001775	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586001776	PYR/PP interface [polypeptide binding]; other site
318586001777	dimer interface [polypeptide binding]; other site
318586001778	TPP binding site [chemical binding]; other site
318586001779	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586001780	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
318586001781	TPP-binding site [chemical binding]; other site
318586001782	Phosphate transporter family; Region: PHO4; pfam01384
318586001783	Phosphate transporter family; Region: PHO4; pfam01384
318586001784	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
318586001785	nudix motif; other site
318586001786	hypothetical protein; Provisional; Region: PRK09256
318586001787	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
318586001788	Transglycosylase; Region: Transgly; pfam00912
318586001789	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
318586001790	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
318586001791	hypothetical protein; Provisional; Region: PRK05415
318586001792	Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616
318586001793	Domain of unknown function (DUF697); Region: DUF697; pfam05128
318586001794	YcjX-like family, DUF463; Region: DUF463; pfam04317
318586001795	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
318586001796	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586001797	ATP binding site [chemical binding]; other site
318586001798	putative Mg++ binding site [ion binding]; other site
318586001799	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
318586001800	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
318586001801	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
318586001802	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
318586001803	putative active site [active]
318586001804	substrate binding site [chemical binding]; other site
318586001805	putative cosubstrate binding site; other site
318586001806	catalytic site [active]
318586001807	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
318586001808	substrate binding site [chemical binding]; other site
318586001809	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
318586001810	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
318586001811	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
318586001812	active site
318586001813	catalytic residues [active]
318586001814	metal binding site [ion binding]; metal-binding site
318586001815	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
318586001816	active site
318586001817	catalytic residues [active]
318586001818	metal binding site [ion binding]; metal-binding site
318586001819	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
318586001820	active site
318586001821	catalytic residues [active]
318586001822	metal binding site [ion binding]; metal-binding site
318586001823	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
318586001824	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586001825	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586001826	homodimer interface [polypeptide binding]; other site
318586001827	catalytic residue [active]
318586001828	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586001829	multidrug efflux protein; Reviewed; Region: PRK01766
318586001830	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
318586001831	cation binding site [ion binding]; other site
318586001832	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586001833	AsnC family; Region: AsnC_trans_reg; pfam01037
318586001834	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
318586001835	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586001836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586001837	homodimer interface [polypeptide binding]; other site
318586001838	catalytic residue [active]
318586001839	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586001840	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586001841	putative DNA binding site [nucleotide binding]; other site
318586001842	putative Zn2+ binding site [ion binding]; other site
318586001843	AsnC family; Region: AsnC_trans_reg; pfam01037
318586001844	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
318586001845	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
318586001846	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
318586001847	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
318586001848	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
318586001849	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
318586001850	Active Sites [active]
318586001851	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
318586001852	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
318586001853	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
318586001854	FAD binding pocket [chemical binding]; other site
318586001855	FAD binding motif [chemical binding]; other site
318586001856	phosphate binding motif [ion binding]; other site
318586001857	beta-alpha-beta structure motif; other site
318586001858	NAD binding pocket [chemical binding]; other site
318586001859	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
318586001860	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
318586001861	active site
318586001862	interdomain interaction site; other site
318586001863	putative metal-binding site [ion binding]; other site
318586001864	nucleotide binding site [chemical binding]; other site
318586001865	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
318586001866	domain I; other site
318586001867	DNA binding groove [nucleotide binding]
318586001868	phosphate binding site [ion binding]; other site
318586001869	domain II; other site
318586001870	domain III; other site
318586001871	nucleotide binding site [chemical binding]; other site
318586001872	catalytic site [active]
318586001873	domain IV; other site
318586001874	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
318586001875	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
318586001876	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
318586001877	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
318586001878	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
318586001879	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
318586001880	Uncharacterized conserved protein [Function unknown]; Region: COG3189
318586001881	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
318586001882	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
318586001883	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
318586001884	DctM-like transporters; Region: DctM; pfam06808
318586001885	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
318586001886	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
318586001887	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
318586001888	Phosphate transporter family; Region: PHO4; pfam01384
318586001889	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
318586001890	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
318586001891	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586001892	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586001893	WHG domain; Region: WHG; pfam13305
318586001894	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
318586001895	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
318586001896	dimer interface [polypeptide binding]; other site
318586001897	active site
318586001898	CoA binding pocket [chemical binding]; other site
318586001899	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586001900	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586001901	NAD(P) binding site [chemical binding]; other site
318586001902	active site
318586001903	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
318586001904	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
318586001905	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
318586001906	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586001907	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586001908	DNA binding site [nucleotide binding]
318586001909	domain linker motif; other site
318586001910	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
318586001911	putative dimerization interface [polypeptide binding]; other site
318586001912	putative ligand binding site [chemical binding]; other site
318586001913	xanthine permease; Region: pbuX; TIGR03173
318586001914	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
318586001915	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586001916	active site
318586001917	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586001918	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
318586001919	nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483
318586001920	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
318586001921	Na binding site [ion binding]; other site
318586001922	substrate binding site [chemical binding]; other site
318586001923	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
318586001924	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586001925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586001926	DNA-binding site [nucleotide binding]; DNA binding site
318586001927	FCD domain; Region: FCD; pfam07729
318586001928	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586001929	active site
318586001930	TolQ protein; Region: tolQ; TIGR02796
318586001931	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
318586001932	TolR protein; Region: tolR; TIGR02801
318586001933	translocation protein TolB; Provisional; Region: tolB; PRK05137
318586001934	TolB amino-terminal domain; Region: TolB_N; pfam04052
318586001935	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
318586001936	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
318586001937	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
318586001938	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
318586001939	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
318586001940	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586001941	ligand binding site [chemical binding]; other site
318586001942	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
318586001943	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
318586001944	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
318586001945	Ligand Binding Site [chemical binding]; other site
318586001946	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
318586001947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586001948	Walker A motif; other site
318586001949	ATP binding site [chemical binding]; other site
318586001950	Walker B motif; other site
318586001951	arginine finger; other site
318586001952	Peptidase family M41; Region: Peptidase_M41; pfam01434
318586001953	Chorismate mutase type II; Region: CM_2; smart00830
318586001954	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586001955	CoenzymeA binding site [chemical binding]; other site
318586001956	subunit interaction site [polypeptide binding]; other site
318586001957	PHB binding site; other site
318586001958	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
318586001959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586001960	Walker A motif; other site
318586001961	ATP binding site [chemical binding]; other site
318586001962	Walker B motif; other site
318586001963	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
318586001964	Peptidase family M48; Region: Peptidase_M48; cl12018
318586001965	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
318586001966	RuvA N terminal domain; Region: RuvA_N; pfam01330
318586001967	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
318586001968	active site
318586001969	putative DNA-binding cleft [nucleotide binding]; other site
318586001970	dimer interface [polypeptide binding]; other site
318586001971	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
318586001972	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586001973	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
318586001974	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
318586001975	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
318586001976	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
318586001977	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586001978	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
318586001979	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
318586001980	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
318586001981	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
318586001982	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
318586001983	dimer interface [polypeptide binding]; other site
318586001984	active site
318586001985	catalytic residue [active]
318586001986	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586001987	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586001988	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586001989	catalytic residue [active]
318586001990	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586001991	EamA-like transporter family; Region: EamA; pfam00892
318586001992	EamA-like transporter family; Region: EamA; pfam00892
318586001993	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
318586001994	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
318586001995	active site
318586001996	dimerization interface [polypeptide binding]; other site
318586001997	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586001998	DNA-binding site [nucleotide binding]; DNA binding site
318586001999	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
318586002000	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
318586002001	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
318586002002	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
318586002003	active site
318586002004	imidazolonepropionase; Validated; Region: PRK09356
318586002005	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
318586002006	active site
318586002007	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
318586002008	active sites [active]
318586002009	tetramer interface [polypeptide binding]; other site
318586002010	N-formylglutamate amidohydrolase; Region: FGase; cl01522
318586002011	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586002012	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586002013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586002014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586002015	active site
318586002016	urocanate hydratase; Provisional; Region: PRK05414
318586002017	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586002018	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586002019	substrate binding pocket [chemical binding]; other site
318586002020	membrane-bound complex binding site; other site
318586002021	hinge residues; other site
318586002022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002023	dimer interface [polypeptide binding]; other site
318586002024	conserved gate region; other site
318586002025	putative PBP binding loops; other site
318586002026	ABC-ATPase subunit interface; other site
318586002027	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586002028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002029	dimer interface [polypeptide binding]; other site
318586002030	conserved gate region; other site
318586002031	putative PBP binding loops; other site
318586002032	ABC-ATPase subunit interface; other site
318586002033	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586002034	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586002035	Walker A/P-loop; other site
318586002036	ATP binding site [chemical binding]; other site
318586002037	Q-loop/lid; other site
318586002038	ABC transporter signature motif; other site
318586002039	Walker B; other site
318586002040	D-loop; other site
318586002041	H-loop/switch region; other site
318586002042	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
318586002043	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
318586002044	active site
318586002045	FMN binding site [chemical binding]; other site
318586002046	substrate binding site [chemical binding]; other site
318586002047	homotetramer interface [polypeptide binding]; other site
318586002048	catalytic residue [active]
318586002049	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
318586002050	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
318586002051	nucleophile elbow; other site
318586002052	Patatin phospholipase; Region: DUF3734; pfam12536
318586002053	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
318586002054	Domain of unknown function DUF21; Region: DUF21; pfam01595
318586002055	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
318586002056	Transporter associated domain; Region: CorC_HlyC; smart01091
318586002057	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
318586002058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586002059	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
318586002060	dimerization interface [polypeptide binding]; other site
318586002061	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
318586002062	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
318586002063	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
318586002064	tonB-system energizer ExbB; Region: exbB; TIGR02797
318586002065	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
318586002066	FAD binding pocket [chemical binding]; other site
318586002067	FAD binding motif [chemical binding]; other site
318586002068	phosphate binding motif [ion binding]; other site
318586002069	NAD binding pocket [chemical binding]; other site
318586002070	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
318586002071	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586002072	catalytic residue [active]
318586002073	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586002074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586002075	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
318586002076	Walker A/P-loop; other site
318586002077	ATP binding site [chemical binding]; other site
318586002078	Q-loop/lid; other site
318586002079	ABC transporter signature motif; other site
318586002080	Walker B; other site
318586002081	D-loop; other site
318586002082	H-loop/switch region; other site
318586002083	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
318586002084	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
318586002085	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
318586002086	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
318586002087	active site
318586002088	DNA polymerase IV; Validated; Region: PRK02406
318586002089	DNA binding site [nucleotide binding]
318586002090	Protein of unknown function (DUF533); Region: DUF533; pfam04391
318586002091	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
318586002092	putative metal binding site [ion binding]; other site
318586002093	elongation factor Tu; Reviewed; Region: PRK00049
318586002094	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
318586002095	G1 box; other site
318586002096	GEF interaction site [polypeptide binding]; other site
318586002097	GTP/Mg2+ binding site [chemical binding]; other site
318586002098	Switch I region; other site
318586002099	G2 box; other site
318586002100	G3 box; other site
318586002101	Switch II region; other site
318586002102	G4 box; other site
318586002103	G5 box; other site
318586002104	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
318586002105	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
318586002106	Antibiotic Binding Site [chemical binding]; other site
318586002107	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
318586002108	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
318586002109	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
318586002110	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586002111	Uncharacterized conserved protein [Function unknown]; Region: COG3791
318586002112	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
318586002113	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
318586002114	trimer interface [polypeptide binding]; other site
318586002115	active site
318586002116	substrate binding site [chemical binding]; other site
318586002117	CoA binding site [chemical binding]; other site
318586002118	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586002119	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586002120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586002121	Walker A/P-loop; other site
318586002122	ATP binding site [chemical binding]; other site
318586002123	Q-loop/lid; other site
318586002124	ABC transporter signature motif; other site
318586002125	Walker B; other site
318586002126	D-loop; other site
318586002127	H-loop/switch region; other site
318586002128	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
318586002129	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
318586002130	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
318586002131	putative homodimer interface [polypeptide binding]; other site
318586002132	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
318586002133	heterodimer interface [polypeptide binding]; other site
318586002134	homodimer interface [polypeptide binding]; other site
318586002135	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
318586002136	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
318586002137	23S rRNA interface [nucleotide binding]; other site
318586002138	L7/L12 interface [polypeptide binding]; other site
318586002139	putative thiostrepton binding site; other site
318586002140	L25 interface [polypeptide binding]; other site
318586002141	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
318586002142	mRNA/rRNA interface [nucleotide binding]; other site
318586002143	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
318586002144	23S rRNA interface [nucleotide binding]; other site
318586002145	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
318586002146	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
318586002147	core dimer interface [polypeptide binding]; other site
318586002148	peripheral dimer interface [polypeptide binding]; other site
318586002149	L10 interface [polypeptide binding]; other site
318586002150	L11 interface [polypeptide binding]; other site
318586002151	putative EF-Tu interaction site [polypeptide binding]; other site
318586002152	putative EF-G interaction site [polypeptide binding]; other site
318586002153	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
318586002154	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
318586002155	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
318586002156	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
318586002157	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
318586002158	RPB3 interaction site [polypeptide binding]; other site
318586002159	RPB1 interaction site [polypeptide binding]; other site
318586002160	RPB11 interaction site [polypeptide binding]; other site
318586002161	RPB10 interaction site [polypeptide binding]; other site
318586002162	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
318586002163	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
318586002164	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
318586002165	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
318586002166	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
318586002167	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
318586002168	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
318586002169	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
318586002170	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
318586002171	DNA binding site [nucleotide binding]
318586002172	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
318586002173	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
318586002174	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586002175	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
318586002176	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
318586002177	S17 interaction site [polypeptide binding]; other site
318586002178	S8 interaction site; other site
318586002179	16S rRNA interaction site [nucleotide binding]; other site
318586002180	streptomycin interaction site [chemical binding]; other site
318586002181	23S rRNA interaction site [nucleotide binding]; other site
318586002182	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
318586002183	30S ribosomal protein S7; Validated; Region: PRK05302
318586002184	elongation factor G; Reviewed; Region: PRK00007
318586002185	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
318586002186	G1 box; other site
318586002187	putative GEF interaction site [polypeptide binding]; other site
318586002188	GTP/Mg2+ binding site [chemical binding]; other site
318586002189	Switch I region; other site
318586002190	G2 box; other site
318586002191	G3 box; other site
318586002192	Switch II region; other site
318586002193	G4 box; other site
318586002194	G5 box; other site
318586002195	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
318586002196	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
318586002197	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
318586002198	elongation factor Tu; Reviewed; Region: PRK00049
318586002199	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
318586002200	G1 box; other site
318586002201	GEF interaction site [polypeptide binding]; other site
318586002202	GTP/Mg2+ binding site [chemical binding]; other site
318586002203	Switch I region; other site
318586002204	G2 box; other site
318586002205	G3 box; other site
318586002206	Switch II region; other site
318586002207	G4 box; other site
318586002208	G5 box; other site
318586002209	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
318586002210	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
318586002211	Antibiotic Binding Site [chemical binding]; other site
318586002212	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
318586002213	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
318586002214	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
318586002215	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
318586002216	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
318586002217	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
318586002218	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
318586002219	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
318586002220	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
318586002221	putative translocon binding site; other site
318586002222	protein-rRNA interface [nucleotide binding]; other site
318586002223	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
318586002224	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
318586002225	G-X-X-G motif; other site
318586002226	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
318586002227	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
318586002228	23S rRNA interface [nucleotide binding]; other site
318586002229	5S rRNA interface [nucleotide binding]; other site
318586002230	putative antibiotic binding site [chemical binding]; other site
318586002231	L25 interface [polypeptide binding]; other site
318586002232	L27 interface [polypeptide binding]; other site
318586002233	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
318586002234	23S rRNA interface [nucleotide binding]; other site
318586002235	putative translocon interaction site; other site
318586002236	signal recognition particle (SRP54) interaction site; other site
318586002237	L23 interface [polypeptide binding]; other site
318586002238	trigger factor interaction site; other site
318586002239	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
318586002240	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
318586002241	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
318586002242	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
318586002243	RNA binding site [nucleotide binding]; other site
318586002244	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
318586002245	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
318586002246	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
318586002247	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
318586002248	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
318586002249	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
318586002250	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
318586002251	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
318586002252	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
318586002253	5S rRNA interface [nucleotide binding]; other site
318586002254	23S rRNA interface [nucleotide binding]; other site
318586002255	L5 interface [polypeptide binding]; other site
318586002256	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
318586002257	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
318586002258	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
318586002259	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
318586002260	23S rRNA binding site [nucleotide binding]; other site
318586002261	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
318586002262	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
318586002263	SecY translocase; Region: SecY; pfam00344
318586002264	adenylate kinase; Reviewed; Region: adk; PRK00279
318586002265	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
318586002266	AMP-binding site [chemical binding]; other site
318586002267	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
318586002268	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
318586002269	30S ribosomal protein S13; Region: bact_S13; TIGR03631
318586002270	30S ribosomal protein S11; Validated; Region: PRK05309
318586002271	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
318586002272	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
318586002273	alphaNTD - beta interaction site [polypeptide binding]; other site
318586002274	alphaNTD homodimer interface [polypeptide binding]; other site
318586002275	alphaNTD - beta' interaction site [polypeptide binding]; other site
318586002276	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
318586002277	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
318586002278	Autoinducer binding domain; Region: Autoind_bind; pfam03472
318586002279	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
318586002280	DNA binding residues [nucleotide binding]
318586002281	dimerization interface [polypeptide binding]; other site
318586002282	Autoinducer synthetase; Region: Autoind_synth; cl17404
318586002283	recombination factor protein RarA; Reviewed; Region: PRK13342
318586002284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586002285	Walker A motif; other site
318586002286	ATP binding site [chemical binding]; other site
318586002287	Walker B motif; other site
318586002288	arginine finger; other site
318586002289	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
318586002290	CrcB-like protein; Region: CRCB; cl09114
318586002291	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
318586002292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
318586002293	RNA binding surface [nucleotide binding]; other site
318586002294	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
318586002295	active site
318586002296	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
318586002297	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586002298	active site
318586002299	motif I; other site
318586002300	motif II; other site
318586002301	ATP12 chaperone protein; Region: ATP12; pfam07542
318586002302	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
318586002303	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586002304	substrate binding pocket [chemical binding]; other site
318586002305	membrane-bound complex binding site; other site
318586002306	hinge residues; other site
318586002307	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
318586002308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002309	conserved gate region; other site
318586002310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002311	putative PBP binding loops; other site
318586002312	dimer interface [polypeptide binding]; other site
318586002313	ABC-ATPase subunit interface; other site
318586002314	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586002315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002316	dimer interface [polypeptide binding]; other site
318586002317	conserved gate region; other site
318586002318	putative PBP binding loops; other site
318586002319	ABC-ATPase subunit interface; other site
318586002320	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586002321	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586002322	Walker A/P-loop; other site
318586002323	ATP binding site [chemical binding]; other site
318586002324	Q-loop/lid; other site
318586002325	ABC transporter signature motif; other site
318586002326	Walker B; other site
318586002327	D-loop; other site
318586002328	H-loop/switch region; other site
318586002329	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
318586002330	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
318586002331	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
318586002332	homodimer interface [polypeptide binding]; other site
318586002333	substrate-cofactor binding pocket; other site
318586002334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586002335	catalytic residue [active]
318586002336	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
318586002337	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586002338	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586002339	Walker A/P-loop; other site
318586002340	ATP binding site [chemical binding]; other site
318586002341	Q-loop/lid; other site
318586002342	ABC transporter signature motif; other site
318586002343	Walker B; other site
318586002344	D-loop; other site
318586002345	H-loop/switch region; other site
318586002346	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586002347	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586002348	Walker A/P-loop; other site
318586002349	ATP binding site [chemical binding]; other site
318586002350	Q-loop/lid; other site
318586002351	ABC transporter signature motif; other site
318586002352	Walker B; other site
318586002353	D-loop; other site
318586002354	H-loop/switch region; other site
318586002355	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586002356	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586002357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002358	dimer interface [polypeptide binding]; other site
318586002359	conserved gate region; other site
318586002360	putative PBP binding loops; other site
318586002361	ABC-ATPase subunit interface; other site
318586002362	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586002363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002364	dimer interface [polypeptide binding]; other site
318586002365	conserved gate region; other site
318586002366	putative PBP binding loops; other site
318586002367	ABC-ATPase subunit interface; other site
318586002368	Transmembrane secretion effector; Region: MFS_3; pfam05977
318586002369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586002370	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
318586002371	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586002372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
318586002373	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586002374	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586002375	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586002376	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586002377	catalytic residue [active]
318586002378	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586002379	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
318586002380	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
318586002381	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
318586002382	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
318586002383	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586002384	motif II; other site
318586002385	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
318586002386	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586002387	catalytic residue [active]
318586002388	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
318586002389	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
318586002390	ligand binding site [chemical binding]; other site
318586002391	NAD binding site [chemical binding]; other site
318586002392	dimerization interface [polypeptide binding]; other site
318586002393	catalytic site [active]
318586002394	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
318586002395	putative L-serine binding site [chemical binding]; other site
318586002396	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
318586002397	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
318586002398	active site
318586002399	metal binding site [ion binding]; metal-binding site
318586002400	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
318586002401	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
318586002402	PhoU domain; Region: PhoU; pfam01895
318586002403	PhoU domain; Region: PhoU; pfam01895
318586002404	hypothetical protein; Provisional; Region: PRK10756
318586002405	CreA protein; Region: CreA; pfam05981
318586002406	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
318586002407	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
318586002408	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
318586002409	anti sigma factor interaction site; other site
318586002410	regulatory phosphorylation site [posttranslational modification]; other site
318586002411	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
318586002412	active site
318586002413	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
318586002414	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
318586002415	Uncharacterized conserved protein [Function unknown]; Region: COG2308
318586002416	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
318586002417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
318586002418	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
318586002419	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
318586002420	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
318586002421	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
318586002422	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
318586002423	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
318586002424	MutS domain I; Region: MutS_I; pfam01624
318586002425	MutS domain II; Region: MutS_II; pfam05188
318586002426	MutS domain III; Region: MutS_III; pfam05192
318586002427	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
318586002428	Walker A/P-loop; other site
318586002429	ATP binding site [chemical binding]; other site
318586002430	Q-loop/lid; other site
318586002431	ABC transporter signature motif; other site
318586002432	Walker B; other site
318586002433	D-loop; other site
318586002434	H-loop/switch region; other site
318586002435	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
318586002436	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586002437	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586002438	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002439	dimer interface [polypeptide binding]; other site
318586002440	conserved gate region; other site
318586002441	putative PBP binding loops; other site
318586002442	ABC-ATPase subunit interface; other site
318586002443	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586002444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002445	dimer interface [polypeptide binding]; other site
318586002446	ABC-ATPase subunit interface; other site
318586002447	putative PBP binding loops; other site
318586002448	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586002449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586002450	Walker A/P-loop; other site
318586002451	ATP binding site [chemical binding]; other site
318586002452	Q-loop/lid; other site
318586002453	ABC transporter signature motif; other site
318586002454	Walker B; other site
318586002455	D-loop; other site
318586002456	H-loop/switch region; other site
318586002457	TOBE domain; Region: TOBE_2; pfam08402
318586002458	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
318586002459	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
318586002460	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
318586002461	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
318586002462	active site
318586002463	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
318586002464	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
318586002465	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
318586002466	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
318586002467	putative NADP binding site [chemical binding]; other site
318586002468	active site
318586002469	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
318586002470	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
318586002471	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
318586002472	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
318586002473	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
318586002474	Probable Catalytic site; other site
318586002475	metal-binding site
318586002476	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
318586002477	active site
318586002478	substrate binding site [chemical binding]; other site
318586002479	cosubstrate binding site; other site
318586002480	catalytic site [active]
318586002481	C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700
318586002482	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586002483	acyl-activating enzyme (AAE) consensus motif; other site
318586002484	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
318586002485	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
318586002486	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
318586002487	AMP binding site [chemical binding]; other site
318586002488	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
318586002489	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
318586002490	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
318586002491	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
318586002492	putative ADP-binding pocket [chemical binding]; other site
318586002493	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586002494	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
318586002495	Bacterial sugar transferase; Region: Bac_transf; pfam02397
318586002496	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
318586002497	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
318586002498	active site
318586002499	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
318586002500	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
318586002501	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
318586002502	Chain length determinant protein; Region: Wzz; cl15801
318586002503	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
318586002504	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
318586002505	Malic enzyme, N-terminal domain; Region: malic; pfam00390
318586002506	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
318586002507	putative NAD(P) binding site [chemical binding]; other site
318586002508	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
318586002509	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
318586002510	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
318586002511	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
318586002512	active site residue [active]
318586002513	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
318586002514	Isochorismatase family; Region: Isochorismatase; pfam00857
318586002515	catalytic triad [active]
318586002516	metal binding site [ion binding]; metal-binding site
318586002517	conserved cis-peptide bond; other site
318586002518	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
318586002519	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
318586002520	active site
318586002521	NAD synthetase; Provisional; Region: PRK13981
318586002522	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
318586002523	multimer interface [polypeptide binding]; other site
318586002524	active site
318586002525	catalytic triad [active]
318586002526	protein interface 1 [polypeptide binding]; other site
318586002527	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
318586002528	homodimer interface [polypeptide binding]; other site
318586002529	NAD binding pocket [chemical binding]; other site
318586002530	ATP binding pocket [chemical binding]; other site
318586002531	Mg binding site [ion binding]; other site
318586002532	active-site loop [active]
318586002533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
318586002534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
318586002535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
318586002536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
318586002537	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586002538	active site
318586002539	LysE type translocator; Region: LysE; cl00565
318586002540	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
318586002541	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
318586002542	NAD binding site [chemical binding]; other site
318586002543	homotetramer interface [polypeptide binding]; other site
318586002544	homodimer interface [polypeptide binding]; other site
318586002545	substrate binding site [chemical binding]; other site
318586002546	active site
318586002547	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
318586002548	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
318586002549	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
318586002550	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586002551	DNA-binding site [nucleotide binding]; DNA binding site
318586002552	RNA-binding motif; other site
318586002553	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586002554	DNA-binding site [nucleotide binding]; DNA binding site
318586002555	RNA-binding motif; other site
318586002556	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
318586002557	aspartate kinase; Reviewed; Region: PRK06635
318586002558	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
318586002559	putative nucleotide binding site [chemical binding]; other site
318586002560	putative catalytic residues [active]
318586002561	putative Mg ion binding site [ion binding]; other site
318586002562	putative aspartate binding site [chemical binding]; other site
318586002563	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
318586002564	putative allosteric regulatory site; other site
318586002565	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
318586002566	putative allosteric regulatory residue; other site
318586002567	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
318586002568	GAF domain; Region: GAF; pfam01590
318586002569	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
318586002570	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
318586002571	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
318586002572	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586002573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586002574	Walker A/P-loop; other site
318586002575	ATP binding site [chemical binding]; other site
318586002576	Q-loop/lid; other site
318586002577	ABC transporter signature motif; other site
318586002578	Walker B; other site
318586002579	D-loop; other site
318586002580	H-loop/switch region; other site
318586002581	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586002582	putative PBP binding regions; other site
318586002583	ABC-ATPase subunit  interface; other site
318586002584	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586002585	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
318586002586	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
318586002587	putative metal binding site [ion binding]; other site
318586002588	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
318586002589	homodimer interaction site [polypeptide binding]; other site
318586002590	cofactor binding site; other site
318586002591	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
318586002592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586002593	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
318586002594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586002595	ATP binding site [chemical binding]; other site
318586002596	Mg2+ binding site [ion binding]; other site
318586002597	G-X-G motif; other site
318586002598	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
318586002599	Ribonuclease P; Region: Ribonuclease_P; pfam00825
318586002600	Haemolytic domain; Region: Haemolytic; pfam01809
318586002601	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
318586002602	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
318586002603	Ligand Binding Site [chemical binding]; other site
318586002604	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
318586002605	membrane protein insertase; Provisional; Region: PRK01318
318586002606	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
318586002607	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
318586002608	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
318586002609	MOSC domain; Region: MOSC; pfam03473
318586002610	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
318586002611	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
318586002612	G1 box; other site
318586002613	GTP/Mg2+ binding site [chemical binding]; other site
318586002614	Switch I region; other site
318586002615	G2 box; other site
318586002616	G3 box; other site
318586002617	Switch II region; other site
318586002618	G4 box; other site
318586002619	G5 box; other site
318586002620	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
318586002621	feedback inhibition sensing region; other site
318586002622	homohexameric interface [polypeptide binding]; other site
318586002623	nucleotide binding site [chemical binding]; other site
318586002624	N-acetyl-L-glutamate binding site [chemical binding]; other site
318586002625	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
318586002626	catalytic core [active]
318586002627	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
318586002628	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
318586002629	putative substrate binding site [chemical binding]; other site
318586002630	putative ATP binding site [chemical binding]; other site
318586002631	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
318586002632	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
318586002633	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586002634	active site
318586002635	HIGH motif; other site
318586002636	nucleotide binding site [chemical binding]; other site
318586002637	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
318586002638	active site
318586002639	KMSKS motif; other site
318586002640	DNA polymerase III subunit delta'; Validated; Region: PRK08058
318586002641	trigger factor; Provisional; Region: tig; PRK01490
318586002642	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
318586002643	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
318586002644	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
318586002645	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
318586002646	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
318586002647	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
318586002648	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
318586002649	Uncharacterized conserved protein [Function unknown]; Region: COG2353
318586002650	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
318586002651	peptide chain release factor 1; Validated; Region: prfA; PRK00591
318586002652	This domain is found in peptide chain release factors; Region: PCRF; smart00937
318586002653	RF-1 domain; Region: RF-1; pfam00472
318586002654	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
318586002655	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586002656	S-adenosylmethionine binding site [chemical binding]; other site
318586002657	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
318586002658	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
318586002659	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
318586002660	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
318586002661	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
318586002662	SurA N-terminal domain; Region: SurA_N; pfam09312
318586002663	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
318586002664	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
318586002665	Organic solvent tolerance protein; Region: OstA_C; pfam04453
318586002666	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
318586002667	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
318586002668	Predicted permeases [General function prediction only]; Region: COG0795
318586002669	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
318586002670	multifunctional aminopeptidase A; Provisional; Region: PRK00913
318586002671	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
318586002672	interface (dimer of trimers) [polypeptide binding]; other site
318586002673	Substrate-binding/catalytic site; other site
318586002674	Zn-binding sites [ion binding]; other site
318586002675	DNA polymerase III subunit chi; Validated; Region: PRK05728
318586002676	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
318586002677	catalytic motif [active]
318586002678	Catalytic residue [active]
318586002679	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
318586002680	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
318586002681	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
318586002682	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
318586002683	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
318586002684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586002685	Walker A motif; other site
318586002686	ATP binding site [chemical binding]; other site
318586002687	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
318586002688	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
318586002689	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
318586002690	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586002691	MarR family; Region: MarR_2; pfam12802
318586002692	Predicted small secreted protein [Function unknown]; Region: COG5510
318586002693	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
318586002694	Entericidin EcnA/B family; Region: Entericidin; cl02322
318586002695	acyl-CoA esterase; Provisional; Region: PRK10673
318586002696	PGAP1-like protein; Region: PGAP1; pfam07819
318586002697	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
318586002698	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
318586002699	dimer interface [polypeptide binding]; other site
318586002700	active site
318586002701	glycine-pyridoxal phosphate binding site [chemical binding]; other site
318586002702	folate binding site [chemical binding]; other site
318586002703	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
318586002704	ATP-NAD kinase; Region: NAD_kinase; pfam01513
318586002705	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
318586002706	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
318586002707	G1 box; other site
318586002708	putative GEF interaction site [polypeptide binding]; other site
318586002709	GTP/Mg2+ binding site [chemical binding]; other site
318586002710	Switch I region; other site
318586002711	G2 box; other site
318586002712	G3 box; other site
318586002713	Switch II region; other site
318586002714	G4 box; other site
318586002715	G5 box; other site
318586002716	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
318586002717	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
318586002718	EamA-like transporter family; Region: EamA; pfam00892
318586002719	EamA-like transporter family; Region: EamA; cl17759
318586002720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
318586002721	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
318586002722	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
318586002723	Zn2+ binding site [ion binding]; other site
318586002724	Mg2+ binding site [ion binding]; other site
318586002725	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
318586002726	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
318586002727	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
318586002728	putative catalytic site [active]
318586002729	putative phosphate binding site [ion binding]; other site
318586002730	active site
318586002731	metal binding site A [ion binding]; metal-binding site
318586002732	DNA binding site [nucleotide binding]
318586002733	putative AP binding site [nucleotide binding]; other site
318586002734	putative metal binding site B [ion binding]; other site
318586002735	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
318586002736	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
318586002737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586002738	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
318586002739	NAD(P) binding site [chemical binding]; other site
318586002740	active site
318586002741	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
318586002742	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
318586002743	putative ligand binding site [chemical binding]; other site
318586002744	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
318586002745	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586002746	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
318586002747	dimer interface [polypeptide binding]; other site
318586002748	active site
318586002749	metal binding site [ion binding]; metal-binding site
318586002750	glutathione binding site [chemical binding]; other site
318586002751	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
318586002752	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
318586002753	aspartate aminotransferase; Provisional; Region: PRK05764
318586002754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586002755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586002756	homodimer interface [polypeptide binding]; other site
318586002757	catalytic residue [active]
318586002758	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
318586002759	Aspartase; Region: Aspartase; cd01357
318586002760	active sites [active]
318586002761	tetramer interface [polypeptide binding]; other site
318586002762	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586002763	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586002764	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586002765	dimerization interface [polypeptide binding]; other site
318586002766	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
318586002767	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
318586002768	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586002769	putative DNA binding site [nucleotide binding]; other site
318586002770	putative Zn2+ binding site [ion binding]; other site
318586002771	AsnC family; Region: AsnC_trans_reg; pfam01037
318586002772	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
318586002773	Proline dehydrogenase; Region: Pro_dh; pfam01619
318586002774	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
318586002775	Glutamate binding site [chemical binding]; other site
318586002776	NAD binding site [chemical binding]; other site
318586002777	catalytic residues [active]
318586002778	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
318586002779	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
318586002780	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586002781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002782	dimer interface [polypeptide binding]; other site
318586002783	conserved gate region; other site
318586002784	putative PBP binding loops; other site
318586002785	ABC-ATPase subunit interface; other site
318586002786	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
318586002787	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
318586002788	Walker A/P-loop; other site
318586002789	ATP binding site [chemical binding]; other site
318586002790	Q-loop/lid; other site
318586002791	ABC transporter signature motif; other site
318586002792	Walker B; other site
318586002793	D-loop; other site
318586002794	H-loop/switch region; other site
318586002795	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
318586002796	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586002797	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586002798	active site
318586002799	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
318586002800	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
318586002801	active site
318586002802	substrate binding site [chemical binding]; other site
318586002803	Mg2+ binding site [ion binding]; other site
318586002804	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
318586002805	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
318586002806	active site
318586002807	catalytic residues [active]
318586002808	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
318586002809	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
318586002810	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
318586002811	active site
318586002812	dimer interface [polypeptide binding]; other site
318586002813	effector binding site; other site
318586002814	TSCPD domain; Region: TSCPD; pfam12637
318586002815	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
318586002816	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
318586002817	catalytic residues [active]
318586002818	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
318586002819	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586002820	acyl-activating enzyme (AAE) consensus motif; other site
318586002821	AMP binding site [chemical binding]; other site
318586002822	active site
318586002823	CoA binding site [chemical binding]; other site
318586002824	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586002825	DNA-binding site [nucleotide binding]; DNA binding site
318586002826	RNA-binding motif; other site
318586002827	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
318586002828	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
318586002829	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
318586002830	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
318586002831	active site
318586002832	dimer interface [polypeptide binding]; other site
318586002833	motif 1; other site
318586002834	motif 2; other site
318586002835	motif 3; other site
318586002836	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
318586002837	anticodon binding site; other site
318586002838	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586002839	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
318586002840	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
318586002841	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
318586002842	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
318586002843	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
318586002844	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
318586002845	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
318586002846	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586002847	active site
318586002848	catalytic residues [active]
318586002849	DNA binding site [nucleotide binding]
318586002850	Int/Topo IB signature motif; other site
318586002851	Protein of unknown function (DUF550); Region: DUF550; pfam04447
318586002852	DNA methylase; Region: N6_N4_Mtase; cl17433
318586002853	DNA polymerase III subunit beta; Validated; Region: PRK05643
318586002854	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
318586002855	putative DNA binding surface [nucleotide binding]; other site
318586002856	dimer interface [polypeptide binding]; other site
318586002857	beta-clamp/clamp loader binding surface; other site
318586002858	beta-clamp/translesion DNA polymerase binding surface; other site
318586002859	Predicted transcriptional regulator [Transcription]; Region: COG2932
318586002860	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586002861	non-specific DNA binding site [nucleotide binding]; other site
318586002862	salt bridge; other site
318586002863	sequence-specific DNA binding site [nucleotide binding]; other site
318586002864	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
318586002865	Catalytic site [active]
318586002866	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
318586002867	D5 N terminal like; Region: D5_N; smart00885
318586002868	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
318586002869	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
318586002870	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586002871	active site
318586002872	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
318586002873	DNA-binding interface [nucleotide binding]; DNA binding site
318586002874	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
318586002875	Phage portal protein; Region: Phage_portal; pfam04860
318586002876	Phage-related protein [Function unknown]; Region: COG4695; cl01923
318586002877	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
318586002878	oligomer interface [polypeptide binding]; other site
318586002879	active site residues [active]
318586002880	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
318586002881	Phage capsid family; Region: Phage_capsid; pfam05065
318586002882	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
318586002883	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
318586002884	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
318586002885	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
318586002886	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
318586002887	tape measure domain; Region: tape_meas_nterm; TIGR02675
318586002888	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586002889	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
318586002890	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586002891	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
318586002892	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; pfam01515
318586002893	Predicted membrane protein [Function unknown]; Region: COG2855
318586002894	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
318586002895	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586002896	PYR/PP interface [polypeptide binding]; other site
318586002897	dimer interface [polypeptide binding]; other site
318586002898	TPP binding site [chemical binding]; other site
318586002899	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586002900	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
318586002901	TPP-binding site [chemical binding]; other site
318586002902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586002903	D-galactonate transporter; Region: 2A0114; TIGR00893
318586002904	putative substrate translocation pore; other site
318586002905	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
318586002906	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586002907	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
318586002908	acyl-activating enzyme (AAE) consensus motif; other site
318586002909	acyl-activating enzyme (AAE) consensus motif; other site
318586002910	putative AMP binding site [chemical binding]; other site
318586002911	putative active site [active]
318586002912	putative CoA binding site [chemical binding]; other site
318586002913	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586002914	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
318586002915	NAD(P) binding site [chemical binding]; other site
318586002916	catalytic residues [active]
318586002917	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586002918	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586002919	DNA binding site [nucleotide binding]
318586002920	domain linker motif; other site
318586002921	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
318586002922	putative dimerization interface [polypeptide binding]; other site
318586002923	putative ligand binding site [chemical binding]; other site
318586002924	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586002925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586002926	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586002927	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586002928	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
318586002929	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586002930	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
318586002931	active site
318586002932	Creatinine amidohydrolase; Region: Creatininase; pfam02633
318586002933	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586002934	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586002935	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586002936	dimerization interface [polypeptide binding]; other site
318586002937	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586002938	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586002939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002940	ABC-ATPase subunit interface; other site
318586002941	putative PBP binding loops; other site
318586002942	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586002943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002944	dimer interface [polypeptide binding]; other site
318586002945	conserved gate region; other site
318586002946	putative PBP binding loops; other site
318586002947	ABC-ATPase subunit interface; other site
318586002948	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586002949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586002950	Walker A/P-loop; other site
318586002951	ATP binding site [chemical binding]; other site
318586002952	Q-loop/lid; other site
318586002953	ABC transporter signature motif; other site
318586002954	Walker B; other site
318586002955	D-loop; other site
318586002956	H-loop/switch region; other site
318586002957	TOBE domain; Region: TOBE_2; pfam08402
318586002958	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586002959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586002960	substrate binding pocket [chemical binding]; other site
318586002961	membrane-bound complex binding site; other site
318586002962	hinge residues; other site
318586002963	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586002964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002965	dimer interface [polypeptide binding]; other site
318586002966	conserved gate region; other site
318586002967	putative PBP binding loops; other site
318586002968	ABC-ATPase subunit interface; other site
318586002969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586002970	dimer interface [polypeptide binding]; other site
318586002971	conserved gate region; other site
318586002972	putative PBP binding loops; other site
318586002973	ABC-ATPase subunit interface; other site
318586002974	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586002975	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586002976	Walker A/P-loop; other site
318586002977	ATP binding site [chemical binding]; other site
318586002978	Q-loop/lid; other site
318586002979	ABC transporter signature motif; other site
318586002980	Walker B; other site
318586002981	D-loop; other site
318586002982	H-loop/switch region; other site
318586002983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586002984	putative substrate translocation pore; other site
318586002985	choline dehydrogenase; Validated; Region: PRK02106
318586002986	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586002987	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
318586002988	putative ligand binding site [chemical binding]; other site
318586002989	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
318586002990	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586002991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586002992	Walker A/P-loop; other site
318586002993	ATP binding site [chemical binding]; other site
318586002994	Q-loop/lid; other site
318586002995	ABC transporter signature motif; other site
318586002996	Walker B; other site
318586002997	D-loop; other site
318586002998	H-loop/switch region; other site
318586002999	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
318586003000	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586003001	TM-ABC transporter signature motif; other site
318586003002	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586003003	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586003004	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
318586003005	dimerization interface [polypeptide binding]; other site
318586003006	substrate binding pocket [chemical binding]; other site
318586003007	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
318586003008	Amidohydrolase; Region: Amidohydro_2; pfam04909
318586003009	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586003010	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
318586003011	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
318586003012	active site
318586003013	EamA-like transporter family; Region: EamA; pfam00892
318586003014	NIPSNAP; Region: NIPSNAP; pfam07978
318586003015	short chain dehydrogenase; Provisional; Region: PRK06138
318586003016	classical (c) SDRs; Region: SDR_c; cd05233
318586003017	NAD(P) binding site [chemical binding]; other site
318586003018	active site
318586003019	L-aspartate dehydrogenase; Provisional; Region: PRK13303
318586003020	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
318586003021	Domain of unknown function DUF108; Region: DUF108; pfam01958
318586003022	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
318586003023	Serine hydrolase (FSH1); Region: FSH1; pfam03959
318586003024	Cupin domain; Region: Cupin_2; pfam07883
318586003025	choline dehydrogenase; Validated; Region: PRK02106
318586003026	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
318586003027	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586003028	Proline racemase; Region: Pro_racemase; pfam05544
318586003029	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
318586003030	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586003031	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586003032	DNA binding site [nucleotide binding]
318586003033	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
318586003034	putative dimerization interface [polypeptide binding]; other site
318586003035	putative ligand binding site [chemical binding]; other site
318586003036	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586003037	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586003038	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003039	dimer interface [polypeptide binding]; other site
318586003040	conserved gate region; other site
318586003041	putative PBP binding loops; other site
318586003042	ABC-ATPase subunit interface; other site
318586003043	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586003044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003045	dimer interface [polypeptide binding]; other site
318586003046	conserved gate region; other site
318586003047	putative PBP binding loops; other site
318586003048	ABC-ATPase subunit interface; other site
318586003049	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
318586003050	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586003051	Walker A/P-loop; other site
318586003052	ATP binding site [chemical binding]; other site
318586003053	Q-loop/lid; other site
318586003054	ABC transporter signature motif; other site
318586003055	Walker B; other site
318586003056	D-loop; other site
318586003057	H-loop/switch region; other site
318586003058	TOBE domain; Region: TOBE_2; pfam08402
318586003059	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586003060	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
318586003061	NAD(P) binding site [chemical binding]; other site
318586003062	catalytic residues [active]
318586003063	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586003064	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586003065	NAD(P) binding site [chemical binding]; other site
318586003066	catalytic residues [active]
318586003067	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586003068	putative deaminase; Validated; Region: PRK06846
318586003069	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
318586003070	active site
318586003071	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586003072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586003073	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586003074	dimerization interface [polypeptide binding]; other site
318586003075	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
318586003076	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
318586003077	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
318586003078	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
318586003079	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
318586003080	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
318586003081	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
318586003082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586003083	Helix-turn-helix domain; Region: HTH_18; pfam12833
318586003084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586003085	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
318586003086	NAD(P) binding site [chemical binding]; other site
318586003087	active site
318586003088	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
318586003089	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
318586003090	MarR family; Region: MarR; pfam01047
318586003091	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586003092	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586003093	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
318586003094	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
318586003095	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586003096	catalytic residue [active]
318586003097	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586003098	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586003099	substrate binding pocket [chemical binding]; other site
318586003100	membrane-bound complex binding site; other site
318586003101	hinge residues; other site
318586003102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003103	dimer interface [polypeptide binding]; other site
318586003104	conserved gate region; other site
318586003105	putative PBP binding loops; other site
318586003106	ABC-ATPase subunit interface; other site
318586003107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003108	dimer interface [polypeptide binding]; other site
318586003109	conserved gate region; other site
318586003110	putative PBP binding loops; other site
318586003111	ABC-ATPase subunit interface; other site
318586003112	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586003113	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586003114	Walker A/P-loop; other site
318586003115	ATP binding site [chemical binding]; other site
318586003116	Q-loop/lid; other site
318586003117	ABC transporter signature motif; other site
318586003118	Walker B; other site
318586003119	D-loop; other site
318586003120	H-loop/switch region; other site
318586003121	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
318586003122	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586003123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586003124	Walker A/P-loop; other site
318586003125	ATP binding site [chemical binding]; other site
318586003126	Q-loop/lid; other site
318586003127	ABC transporter signature motif; other site
318586003128	Walker B; other site
318586003129	D-loop; other site
318586003130	H-loop/switch region; other site
318586003131	TOBE domain; Region: TOBE_2; pfam08402
318586003132	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586003133	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586003134	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586003135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003136	dimer interface [polypeptide binding]; other site
318586003137	conserved gate region; other site
318586003138	putative PBP binding loops; other site
318586003139	ABC-ATPase subunit interface; other site
318586003140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003141	dimer interface [polypeptide binding]; other site
318586003142	conserved gate region; other site
318586003143	putative PBP binding loops; other site
318586003144	ABC-ATPase subunit interface; other site
318586003145	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586003146	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
318586003147	active site
318586003148	catalytic residues [active]
318586003149	Beta-lactamase; Region: Beta-lactamase; pfam00144
318586003150	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
318586003151	VirB8 protein; Region: VirB8; cl01500
318586003152	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
318586003153	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586003154	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
318586003155	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586003156	Walker A/P-loop; other site
318586003157	ATP binding site [chemical binding]; other site
318586003158	Q-loop/lid; other site
318586003159	ABC transporter signature motif; other site
318586003160	Walker B; other site
318586003161	D-loop; other site
318586003162	H-loop/switch region; other site
318586003163	TOBE domain; Region: TOBE; pfam03459
318586003164	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586003165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003166	dimer interface [polypeptide binding]; other site
318586003167	conserved gate region; other site
318586003168	putative PBP binding loops; other site
318586003169	ABC-ATPase subunit interface; other site
318586003170	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
318586003171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003172	dimer interface [polypeptide binding]; other site
318586003173	conserved gate region; other site
318586003174	putative PBP binding loops; other site
318586003175	ABC-ATPase subunit interface; other site
318586003176	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586003177	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586003178	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
318586003179	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
318586003180	NAD binding site [chemical binding]; other site
318586003181	dimerization interface [polypeptide binding]; other site
318586003182	product binding site; other site
318586003183	substrate binding site [chemical binding]; other site
318586003184	zinc binding site [ion binding]; other site
318586003185	catalytic residues [active]
318586003186	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
318586003187	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586003188	PYR/PP interface [polypeptide binding]; other site
318586003189	dimer interface [polypeptide binding]; other site
318586003190	TPP binding site [chemical binding]; other site
318586003191	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586003192	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
318586003193	TPP-binding site [chemical binding]; other site
318586003194	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586003195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586003196	non-specific DNA binding site [nucleotide binding]; other site
318586003197	salt bridge; other site
318586003198	sequence-specific DNA binding site [nucleotide binding]; other site
318586003199	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
318586003200	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
318586003201	tetramer interface [polypeptide binding]; other site
318586003202	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
318586003203	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
318586003204	choline dehydrogenase; Validated; Region: PRK02106
318586003205	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586003206	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
318586003207	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
318586003208	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
318586003209	putative active site [active]
318586003210	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
318586003211	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586003212	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
318586003213	dimerization interface [polypeptide binding]; other site
318586003214	substrate binding pocket [chemical binding]; other site
318586003215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586003216	metabolite-proton symporter; Region: 2A0106; TIGR00883
318586003217	putative substrate translocation pore; other site
318586003218	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
318586003219	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
318586003220	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
318586003221	dimer interface [polypeptide binding]; other site
318586003222	active site
318586003223	Transcriptional regulators [Transcription]; Region: FadR; COG2186
318586003224	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586003225	DNA-binding site [nucleotide binding]; DNA binding site
318586003226	FCD domain; Region: FCD; pfam07729
318586003227	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
318586003228	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
318586003229	NADP binding site [chemical binding]; other site
318586003230	dimer interface [polypeptide binding]; other site
318586003231	acyl-CoA synthetase; Validated; Region: PRK08162
318586003232	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
318586003233	acyl-activating enzyme (AAE) consensus motif; other site
318586003234	putative active site [active]
318586003235	AMP binding site [chemical binding]; other site
318586003236	putative CoA binding site [chemical binding]; other site
318586003237	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
318586003238	active site residue [active]
318586003239	Uncharacterized conserved protein [Function unknown]; Region: COG5470
318586003240	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
318586003241	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
318586003242	Na binding site [ion binding]; other site
318586003243	putative substrate binding site [chemical binding]; other site
318586003244	phenylhydantoinase; Validated; Region: PRK08323
318586003245	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
318586003246	tetramer interface [polypeptide binding]; other site
318586003247	active site
318586003248	allantoate amidohydrolase; Reviewed; Region: PRK12893
318586003249	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
318586003250	active site
318586003251	metal binding site [ion binding]; metal-binding site
318586003252	dimer interface [polypeptide binding]; other site
318586003253	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
318586003254	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586003255	FeS/SAM binding site; other site
318586003256	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551
318586003257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586003258	FeS/SAM binding site; other site
318586003259	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
318586003260	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
318586003261	phosphate binding site [ion binding]; other site
318586003262	dimer interface [polypeptide binding]; other site
318586003263	substrate binding site [chemical binding]; other site
318586003264	Guanylyl transferase CofC like; Region: CofC; cl17472
318586003265	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
318586003266	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
318586003267	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
318586003268	F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842
318586003269	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
318586003270	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586003271	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586003272	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
318586003273	Domain of unknown function (DUF336); Region: DUF336; cl01249
318586003274	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
318586003275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586003276	active site
318586003277	phosphorylation site [posttranslational modification]
318586003278	intermolecular recognition site; other site
318586003279	dimerization interface [polypeptide binding]; other site
318586003280	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586003281	dimerization interface [polypeptide binding]; other site
318586003282	DNA binding residues [nucleotide binding]
318586003283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586003284	ATP binding site [chemical binding]; other site
318586003285	Mg2+ binding site [ion binding]; other site
318586003286	G-X-G motif; other site
318586003287	MoxR-like ATPases [General function prediction only]; Region: COG0714
318586003288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586003289	Walker A motif; other site
318586003290	ATP binding site [chemical binding]; other site
318586003291	Walker B motif; other site
318586003292	arginine finger; other site
318586003293	Protein of unknown function DUF58; Region: DUF58; pfam01882
318586003294	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
318586003295	metal ion-dependent adhesion site (MIDAS); other site
318586003296	von Willebrand factor type A domain; Region: VWA_2; pfam13519
318586003297	Oxygen tolerance; Region: BatD; pfam13584
318586003298	short chain dehydrogenase; Provisional; Region: PRK06701
318586003299	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
318586003300	NAD binding site [chemical binding]; other site
318586003301	metal binding site [ion binding]; metal-binding site
318586003302	active site
318586003303	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
318586003304	dimerization interface [polypeptide binding]; other site
318586003305	metal binding site [ion binding]; metal-binding site
318586003306	RNA polymerase sigma factor; Provisional; Region: PRK12547
318586003307	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586003308	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586003309	DNA binding residues [nucleotide binding]
318586003310	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586003311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586003312	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586003313	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
318586003314	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586003315	N-terminal plug; other site
318586003316	ligand-binding site [chemical binding]; other site
318586003317	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586003318	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
318586003319	intersubunit interface [polypeptide binding]; other site
318586003320	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586003321	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586003322	ABC-ATPase subunit  interface; other site
318586003323	dimer interface [polypeptide binding]; other site
318586003324	putative PBP binding regions; other site
318586003325	FecCD transport family; Region: FecCD; pfam01032
318586003326	ABC-ATPase subunit  interface; other site
318586003327	dimer interface [polypeptide binding]; other site
318586003328	putative PBP binding regions; other site
318586003329	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586003330	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586003331	Walker A/P-loop; other site
318586003332	ATP binding site [chemical binding]; other site
318586003333	Q-loop/lid; other site
318586003334	ABC transporter signature motif; other site
318586003335	Walker B; other site
318586003336	D-loop; other site
318586003337	H-loop/switch region; other site
318586003338	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586003339	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586003340	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
318586003341	Walker A/P-loop; other site
318586003342	ATP binding site [chemical binding]; other site
318586003343	Q-loop/lid; other site
318586003344	ABC transporter signature motif; other site
318586003345	Walker B; other site
318586003346	D-loop; other site
318586003347	H-loop/switch region; other site
318586003348	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
318586003349	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
318586003350	intracellular protease, PfpI family; Region: PfpI; TIGR01382
318586003351	conserved cys residue [active]
318586003352	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586003353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586003354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586003355	dimerization interface [polypeptide binding]; other site
318586003356	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586003357	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586003358	substrate binding pocket [chemical binding]; other site
318586003359	membrane-bound complex binding site; other site
318586003360	hinge residues; other site
318586003361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003362	dimer interface [polypeptide binding]; other site
318586003363	conserved gate region; other site
318586003364	putative PBP binding loops; other site
318586003365	ABC-ATPase subunit interface; other site
318586003366	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586003367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003368	dimer interface [polypeptide binding]; other site
318586003369	conserved gate region; other site
318586003370	putative PBP binding loops; other site
318586003371	ABC-ATPase subunit interface; other site
318586003372	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586003373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586003374	Walker A/P-loop; other site
318586003375	ATP binding site [chemical binding]; other site
318586003376	Q-loop/lid; other site
318586003377	ABC transporter signature motif; other site
318586003378	Walker B; other site
318586003379	D-loop; other site
318586003380	H-loop/switch region; other site
318586003381	agmatinase; Region: agmatinase; TIGR01230
318586003382	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
318586003383	oligomer interface [polypeptide binding]; other site
318586003384	active site
318586003385	Mn binding site [ion binding]; other site
318586003386	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586003387	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586003388	Walker A/P-loop; other site
318586003389	ATP binding site [chemical binding]; other site
318586003390	Q-loop/lid; other site
318586003391	ABC transporter signature motif; other site
318586003392	Walker B; other site
318586003393	D-loop; other site
318586003394	H-loop/switch region; other site
318586003395	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
318586003396	active site
318586003397	homotetramer interface [polypeptide binding]; other site
318586003398	homodimer interface [polypeptide binding]; other site
318586003399	Resolvase, N terminal domain; Region: Resolvase; smart00857
318586003400	Recombinase; Region: Recombinase; pfam07508
318586003401	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
318586003402	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586003403	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
318586003404	Domain of unknown function (DUF364); Region: DUF364; pfam04016
318586003405	HPP family; Region: HPP; pfam04982
318586003406	formate dehydrogenase; Provisional; Region: PRK07574
318586003407	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
318586003408	dimerization interface [polypeptide binding]; other site
318586003409	ligand binding site [chemical binding]; other site
318586003410	NAD binding site [chemical binding]; other site
318586003411	catalytic site [active]
318586003412	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
318586003413	active site
318586003414	Mn binding site [ion binding]; other site
318586003415	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
318586003416	nudix motif; other site
318586003417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586003418	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586003419	putative substrate translocation pore; other site
318586003420	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
318586003421	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586003422	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586003423	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
318586003424	intersubunit interface [polypeptide binding]; other site
318586003425	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586003426	ABC-ATPase subunit  interface; other site
318586003427	dimer interface [polypeptide binding]; other site
318586003428	putative PBP binding regions; other site
318586003429	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586003430	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586003431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586003432	Walker A/P-loop; other site
318586003433	ATP binding site [chemical binding]; other site
318586003434	Q-loop/lid; other site
318586003435	ABC transporter signature motif; other site
318586003436	Walker B; other site
318586003437	D-loop; other site
318586003438	H-loop/switch region; other site
318586003439	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
318586003440	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586003441	N-terminal plug; other site
318586003442	ligand-binding site [chemical binding]; other site
318586003443	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
318586003444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586003445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586003446	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
318586003447	dimerizarion interface [polypeptide binding]; other site
318586003448	CrgA pocket; other site
318586003449	substrate binding pocket [chemical binding]; other site
318586003450	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
318586003451	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
318586003452	octamer interface [polypeptide binding]; other site
318586003453	active site
318586003454	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
318586003455	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
318586003456	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
318586003457	dimer interface [polypeptide binding]; other site
318586003458	active site
318586003459	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
318586003460	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
318586003461	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
318586003462	putative alpha subunit interface [polypeptide binding]; other site
318586003463	putative active site [active]
318586003464	putative substrate binding site [chemical binding]; other site
318586003465	Fe binding site [ion binding]; other site
318586003466	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
318586003467	inter-subunit interface; other site
318586003468	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
318586003469	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586003470	catalytic loop [active]
318586003471	iron binding site [ion binding]; other site
318586003472	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
318586003473	FAD binding pocket [chemical binding]; other site
318586003474	FAD binding motif [chemical binding]; other site
318586003475	phosphate binding motif [ion binding]; other site
318586003476	beta-alpha-beta structure motif; other site
318586003477	NAD binding pocket [chemical binding]; other site
318586003478	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
318586003479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586003480	NAD(P) binding site [chemical binding]; other site
318586003481	active site
318586003482	benzoate transport; Region: 2A0115; TIGR00895
318586003483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586003484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586003485	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
318586003486	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586003487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586003488	DNA-binding site [nucleotide binding]; DNA binding site
318586003489	FCD domain; Region: FCD; pfam07729
318586003490	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
318586003491	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
318586003492	ornithine cyclodeaminase; Validated; Region: PRK06141
318586003493	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
318586003494	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
318586003495	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
318586003496	NAD binding site [chemical binding]; other site
318586003497	catalytic Zn binding site [ion binding]; other site
318586003498	structural Zn binding site [ion binding]; other site
318586003499	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
318586003500	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308
318586003501	metal binding site [ion binding]; metal-binding site
318586003502	substrate binding pocket [chemical binding]; other site
318586003503	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
318586003504	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
318586003505	FAD binding pocket [chemical binding]; other site
318586003506	FAD binding motif [chemical binding]; other site
318586003507	phosphate binding motif [ion binding]; other site
318586003508	beta-alpha-beta structure motif; other site
318586003509	NAD binding pocket [chemical binding]; other site
318586003510	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586003511	catalytic loop [active]
318586003512	iron binding site [ion binding]; other site
318586003513	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
318586003514	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
318586003515	[2Fe-2S] cluster binding site [ion binding]; other site
318586003516	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
318586003517	putative alpha subunit interface [polypeptide binding]; other site
318586003518	putative active site [active]
318586003519	putative substrate binding site [chemical binding]; other site
318586003520	Fe binding site [ion binding]; other site
318586003521	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
318586003522	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586003523	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586003524	dimerization interface [polypeptide binding]; other site
318586003525	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
318586003526	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
318586003527	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586003528	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
318586003529	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
318586003530	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
318586003531	Walker A/P-loop; other site
318586003532	ATP binding site [chemical binding]; other site
318586003533	Q-loop/lid; other site
318586003534	ABC transporter signature motif; other site
318586003535	Walker B; other site
318586003536	D-loop; other site
318586003537	H-loop/switch region; other site
318586003538	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
318586003539	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586003540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003541	dimer interface [polypeptide binding]; other site
318586003542	conserved gate region; other site
318586003543	putative PBP binding loops; other site
318586003544	ABC-ATPase subunit interface; other site
318586003545	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
318586003546	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
318586003547	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586003548	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586003549	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
318586003550	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
318586003551	putative active site [active]
318586003552	putative FMN binding site [chemical binding]; other site
318586003553	putative substrate binding site [chemical binding]; other site
318586003554	putative catalytic residue [active]
318586003555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586003556	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586003557	MarR family; Region: MarR_2; pfam12802
318586003558	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
318586003559	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
318586003560	metal binding site [ion binding]; metal-binding site
318586003561	putative dimer interface [polypeptide binding]; other site
318586003562	multiple promoter invertase; Provisional; Region: mpi; PRK13413
318586003563	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
318586003564	catalytic residues [active]
318586003565	catalytic nucleophile [active]
318586003566	Presynaptic Site I dimer interface [polypeptide binding]; other site
318586003567	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
318586003568	Synaptic Flat tetramer interface [polypeptide binding]; other site
318586003569	Synaptic Site I dimer interface [polypeptide binding]; other site
318586003570	DNA binding site [nucleotide binding]
318586003571	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
318586003572	DNA-binding interface [nucleotide binding]; DNA binding site
318586003573	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
318586003574	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
318586003575	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
318586003576	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586003577	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
318586003578	G1 box; other site
318586003579	GTP/Mg2+ binding site [chemical binding]; other site
318586003580	G2 box; other site
318586003581	Switch I region; other site
318586003582	G3 box; other site
318586003583	Switch II region; other site
318586003584	G4 box; other site
318586003585	G5 box; other site
318586003586	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
318586003587	UreF; Region: UreF; pfam01730
318586003588	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
318586003589	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
318586003590	dimer interface [polypeptide binding]; other site
318586003591	catalytic residues [active]
318586003592	urease subunit alpha; Reviewed; Region: ureC; PRK13207
318586003593	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
318586003594	subunit interactions [polypeptide binding]; other site
318586003595	active site
318586003596	flap region; other site
318586003597	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
318586003598	gamma-beta subunit interface [polypeptide binding]; other site
318586003599	alpha-beta subunit interface [polypeptide binding]; other site
318586003600	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
318586003601	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
318586003602	alpha-gamma subunit interface [polypeptide binding]; other site
318586003603	beta-gamma subunit interface [polypeptide binding]; other site
318586003604	UreD urease accessory protein; Region: UreD; pfam01774
318586003605	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586003606	dimerization interface [polypeptide binding]; other site
318586003607	putative DNA binding site [nucleotide binding]; other site
318586003608	putative Zn2+ binding site [ion binding]; other site
318586003609	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
318586003610	putative hydrophobic ligand binding site [chemical binding]; other site
318586003611	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
318586003612	hydrophobic ligand binding site; other site
318586003613	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
318586003614	putative hydrophobic ligand binding site [chemical binding]; other site
318586003615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
318586003616	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
318586003617	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
318586003618	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586003619	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586003620	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
318586003621	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586003622	active site
318586003623	DNA binding site [nucleotide binding]
318586003624	Int/Topo IB signature motif; other site
318586003625	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586003626	non-specific DNA binding site [nucleotide binding]; other site
318586003627	salt bridge; other site
318586003628	sequence-specific DNA binding site [nucleotide binding]; other site
318586003629	Predicted flavoproteins [General function prediction only]; Region: COG2081
318586003630	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586003631	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
318586003632	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
318586003633	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
318586003634	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
318586003635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586003636	Walker A/P-loop; other site
318586003637	ATP binding site [chemical binding]; other site
318586003638	Q-loop/lid; other site
318586003639	ABC transporter signature motif; other site
318586003640	Walker B; other site
318586003641	D-loop; other site
318586003642	H-loop/switch region; other site
318586003643	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
318586003644	ligand binding site [chemical binding]; other site
318586003645	active site
318586003646	Peptidase M15; Region: Peptidase_M15_3; cl01194
318586003647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
318586003648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
318586003649	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586003650	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586003651	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
318586003652	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
318586003653	trimer interface [polypeptide binding]; other site
318586003654	active site
318586003655	UDP-GlcNAc binding site [chemical binding]; other site
318586003656	lipid binding site [chemical binding]; lipid-binding site
318586003657	Phosphopantetheine attachment site; Region: PP-binding; cl09936
318586003658	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
318586003659	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
318586003660	dimer interface [polypeptide binding]; other site
318586003661	active site
318586003662	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586003663	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
318586003664	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
318586003665	active site
318586003666	intersubunit interface [polypeptide binding]; other site
318586003667	catalytic residue [active]
318586003668	Protein of unknown function (DUF1190); Region: DUF1190; pfam06693
318586003669	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
318586003670	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586003671	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
318586003672	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586003673	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003674	dimer interface [polypeptide binding]; other site
318586003675	conserved gate region; other site
318586003676	putative PBP binding loops; other site
318586003677	ABC-ATPase subunit interface; other site
318586003678	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
318586003679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003680	dimer interface [polypeptide binding]; other site
318586003681	conserved gate region; other site
318586003682	ABC-ATPase subunit interface; other site
318586003683	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
318586003684	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586003685	Walker A/P-loop; other site
318586003686	ATP binding site [chemical binding]; other site
318586003687	Q-loop/lid; other site
318586003688	ABC transporter signature motif; other site
318586003689	Walker B; other site
318586003690	D-loop; other site
318586003691	H-loop/switch region; other site
318586003692	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586003693	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
318586003694	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586003695	Walker A/P-loop; other site
318586003696	ATP binding site [chemical binding]; other site
318586003697	Q-loop/lid; other site
318586003698	ABC transporter signature motif; other site
318586003699	Walker B; other site
318586003700	D-loop; other site
318586003701	H-loop/switch region; other site
318586003702	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
318586003703	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586003704	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
318586003705	NAD(P) binding site [chemical binding]; other site
318586003706	catalytic residues [active]
318586003707	catalytic residues [active]
318586003708	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586003709	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
318586003710	NAD(P) binding site [chemical binding]; other site
318586003711	active site
318586003712	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
318586003713	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586003714	ABC-ATPase subunit  interface; other site
318586003715	dimer interface [polypeptide binding]; other site
318586003716	putative PBP binding regions; other site
318586003717	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
318586003718	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586003719	ABC-ATPase subunit  interface; other site
318586003720	dimer interface [polypeptide binding]; other site
318586003721	putative PBP binding regions; other site
318586003722	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
318586003723	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
318586003724	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
318586003725	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
318586003726	metal binding site [ion binding]; metal-binding site
318586003727	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
318586003728	metal binding site 2 [ion binding]; metal-binding site
318586003729	putative DNA binding helix; other site
318586003730	metal binding site 1 [ion binding]; metal-binding site
318586003731	structural Zn2+ binding site [ion binding]; other site
318586003732	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
318586003733	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
318586003734	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
318586003735	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
318586003736	putative active site [active]
318586003737	catalytic residue [active]
318586003738	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
318586003739	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
318586003740	oligomer interface [polypeptide binding]; other site
318586003741	active site residues [active]
318586003742	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
318586003743	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
318586003744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586003745	Walker A motif; other site
318586003746	ATP binding site [chemical binding]; other site
318586003747	Walker B motif; other site
318586003748	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
318586003749	NADH dehydrogenase; Validated; Region: PRK08183
318586003750	mce related protein; Region: MCE; pfam02470
318586003751	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
318586003752	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
318586003753	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
318586003754	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586003755	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586003756	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
318586003757	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
318586003758	carboxyltransferase (CT) interaction site; other site
318586003759	biotinylation site [posttranslational modification]; other site
318586003760	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
318586003761	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
318586003762	putative acyl-acceptor binding pocket; other site
318586003763	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586003764	EamA-like transporter family; Region: EamA; pfam00892
318586003765	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
318586003766	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
318586003767	TPP-binding site [chemical binding]; other site
318586003768	dimer interface [polypeptide binding]; other site
318586003769	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
318586003770	PYR/PP interface [polypeptide binding]; other site
318586003771	dimer interface [polypeptide binding]; other site
318586003772	TPP binding site [chemical binding]; other site
318586003773	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586003774	xanthine permease; Region: pbuX; TIGR03173
318586003775	hypothetical protein; Provisional; Region: PRK11573
318586003776	Domain of unknown function DUF21; Region: DUF21; pfam01595
318586003777	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
318586003778	Transporter associated domain; Region: CorC_HlyC; smart01091
318586003779	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
318586003780	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586003781	active site
318586003782	DNA binding site [nucleotide binding]
318586003783	Int/Topo IB signature motif; other site
318586003784	shikimate kinase; Provisional; Region: PRK13946
318586003785	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
318586003786	ADP binding site [chemical binding]; other site
318586003787	magnesium binding site [ion binding]; other site
318586003788	putative shikimate binding site; other site
318586003789	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
318586003790	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
318586003791	active site
318586003792	dimer interface [polypeptide binding]; other site
318586003793	metal binding site [ion binding]; metal-binding site
318586003794	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
318586003795	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
318586003796	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
318586003797	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
318586003798	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586003799	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
318586003800	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
318586003801	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
318586003802	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586003803	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
318586003804	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
318586003805	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
318586003806	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
318586003807	dimer interface [polypeptide binding]; other site
318586003808	active site
318586003809	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586003810	catalytic residues [active]
318586003811	substrate binding site [chemical binding]; other site
318586003812	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
318586003813	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
318586003814	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586003815	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586003816	acyl-activating enzyme (AAE) consensus motif; other site
318586003817	acyl-activating enzyme (AAE) consensus motif; other site
318586003818	AMP binding site [chemical binding]; other site
318586003819	active site
318586003820	CoA binding site [chemical binding]; other site
318586003821	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
318586003822	trimer interface [polypeptide binding]; other site
318586003823	active site
318586003824	substrate binding site [chemical binding]; other site
318586003825	CoA binding site [chemical binding]; other site
318586003826	Protein of unknown function (DUF563); Region: DUF563; pfam04577
318586003827	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
318586003828	active site
318586003829	catalytic triad [active]
318586003830	oxyanion hole [active]
318586003831	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
318586003832	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
318586003833	inhibitor-cofactor binding pocket; inhibition site
318586003834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586003835	catalytic residue [active]
318586003836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586003837	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
318586003838	NAD(P) binding site [chemical binding]; other site
318586003839	active site
318586003840	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
318586003841	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
318586003842	NADP-binding site; other site
318586003843	homotetramer interface [polypeptide binding]; other site
318586003844	substrate binding site [chemical binding]; other site
318586003845	homodimer interface [polypeptide binding]; other site
318586003846	active site
318586003847	prolyl-tRNA synthetase; Provisional; Region: PRK12325
318586003848	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
318586003849	dimer interface [polypeptide binding]; other site
318586003850	motif 1; other site
318586003851	active site
318586003852	motif 2; other site
318586003853	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
318586003854	active site
318586003855	motif 3; other site
318586003856	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
318586003857	anticodon binding site; other site
318586003858	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
318586003859	Domain of unknown function DUF20; Region: UPF0118; pfam01594
318586003860	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
318586003861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
318586003862	polyphosphate kinase; Provisional; Region: PRK05443
318586003863	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
318586003864	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
318586003865	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
318586003866	putative domain interface [polypeptide binding]; other site
318586003867	putative active site [active]
318586003868	catalytic site [active]
318586003869	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
318586003870	putative active site [active]
318586003871	putative domain interface [polypeptide binding]; other site
318586003872	catalytic site [active]
318586003873	exopolyphosphatase; Region: exo_poly_only; TIGR03706
318586003874	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
318586003875	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
318586003876	active site
318586003877	dimer interface [polypeptide binding]; other site
318586003878	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
318586003879	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
318586003880	AAA domain; Region: AAA_31; pfam13614
318586003881	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586003882	P-loop; other site
318586003883	Magnesium ion binding site [ion binding]; other site
318586003884	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
318586003885	excinuclease ABC subunit B; Provisional; Region: PRK05298
318586003886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586003887	ATP binding site [chemical binding]; other site
318586003888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586003889	nucleotide binding region [chemical binding]; other site
318586003890	ATP-binding site [chemical binding]; other site
318586003891	Ultra-violet resistance protein B; Region: UvrB; pfam12344
318586003892	UvrB/uvrC motif; Region: UVR; pfam02151
318586003893	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
318586003894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586003895	ATP binding site [chemical binding]; other site
318586003896	Mg2+ binding site [ion binding]; other site
318586003897	G-X-G motif; other site
318586003898	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586003899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586003900	active site
318586003901	phosphorylation site [posttranslational modification]
318586003902	intermolecular recognition site; other site
318586003903	dimerization interface [polypeptide binding]; other site
318586003904	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586003905	DNA binding site [nucleotide binding]
318586003906	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
318586003907	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
318586003908	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
318586003909	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
318586003910	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
318586003911	Ligand binding site; other site
318586003912	DXD motif; other site
318586003913	OpgC protein; Region: OpgC_C; pfam10129
318586003914	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
318586003915	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
318586003916	Potassium binding sites [ion binding]; other site
318586003917	Cesium cation binding sites [ion binding]; other site
318586003918	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
318586003919	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
318586003920	active site
318586003921	(T/H)XGH motif; other site
318586003922	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
318586003923	tellurite resistance protein terB; Region: terB; cd07176
318586003924	putative metal binding site [ion binding]; other site
318586003925	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
318586003926	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586003927	active site
318586003928	nucleotide binding site [chemical binding]; other site
318586003929	HIGH motif; other site
318586003930	KMSKS motif; other site
318586003931	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
318586003932	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
318586003933	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586003934	Walker A/P-loop; other site
318586003935	ATP binding site [chemical binding]; other site
318586003936	Q-loop/lid; other site
318586003937	ABC transporter signature motif; other site
318586003938	Walker B; other site
318586003939	D-loop; other site
318586003940	H-loop/switch region; other site
318586003941	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
318586003942	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
318586003943	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586003944	Walker A/P-loop; other site
318586003945	ATP binding site [chemical binding]; other site
318586003946	Q-loop/lid; other site
318586003947	ABC transporter signature motif; other site
318586003948	Walker B; other site
318586003949	D-loop; other site
318586003950	H-loop/switch region; other site
318586003951	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586003952	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
318586003953	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
318586003954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003955	dimer interface [polypeptide binding]; other site
318586003956	conserved gate region; other site
318586003957	putative PBP binding loops; other site
318586003958	ABC-ATPase subunit interface; other site
318586003959	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
318586003960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003961	dimer interface [polypeptide binding]; other site
318586003962	conserved gate region; other site
318586003963	putative PBP binding loops; other site
318586003964	ABC-ATPase subunit interface; other site
318586003965	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
318586003966	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
318586003967	peptide binding site [polypeptide binding]; other site
318586003968	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
318586003969	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586003970	active site
318586003971	HIGH motif; other site
318586003972	nucleotide binding site [chemical binding]; other site
318586003973	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
318586003974	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
318586003975	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
318586003976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586003977	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
318586003978	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
318586003979	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
318586003980	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
318586003981	catalytic motif [active]
318586003982	Zn binding site [ion binding]; other site
318586003983	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
318586003984	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
318586003985	SnoaL-like domain; Region: SnoaL_3; pfam13474
318586003986	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
318586003987	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
318586003988	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
318586003989	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
318586003990	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586003991	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
318586003992	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586003993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586003994	dimer interface [polypeptide binding]; other site
318586003995	conserved gate region; other site
318586003996	putative PBP binding loops; other site
318586003997	ABC-ATPase subunit interface; other site
318586003998	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586003999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586004000	dimer interface [polypeptide binding]; other site
318586004001	conserved gate region; other site
318586004002	putative PBP binding loops; other site
318586004003	ABC-ATPase subunit interface; other site
318586004004	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586004005	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004006	Walker A/P-loop; other site
318586004007	ATP binding site [chemical binding]; other site
318586004008	Q-loop/lid; other site
318586004009	ABC transporter signature motif; other site
318586004010	Walker B; other site
318586004011	D-loop; other site
318586004012	H-loop/switch region; other site
318586004013	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586004014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004015	Walker A/P-loop; other site
318586004016	ATP binding site [chemical binding]; other site
318586004017	Q-loop/lid; other site
318586004018	ABC transporter signature motif; other site
318586004019	Walker B; other site
318586004020	D-loop; other site
318586004021	H-loop/switch region; other site
318586004022	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
318586004023	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
318586004024	tetramer interface [polypeptide binding]; other site
318586004025	active site
318586004026	Mg2+/Mn2+ binding site [ion binding]; other site
318586004027	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
318586004028	methylcitrate synthase; Provisional; Region: PRK12351
318586004029	oxalacetate binding site [chemical binding]; other site
318586004030	citrylCoA binding site [chemical binding]; other site
318586004031	coenzyme A binding site [chemical binding]; other site
318586004032	catalytic triad [active]
318586004033	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
318586004034	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
318586004035	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586004036	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586004037	sequence-specific DNA binding site [nucleotide binding]; other site
318586004038	salt bridge; other site
318586004039	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
318586004040	Domain of unknown function (DUF955); Region: DUF955; pfam06114
318586004041	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
318586004042	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586004043	active site 2 [active]
318586004044	active site 1 [active]
318586004045	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586004046	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
318586004047	methionine synthase; Provisional; Region: PRK01207
318586004048	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
318586004049	substrate binding site [chemical binding]; other site
318586004050	THF binding site; other site
318586004051	zinc-binding site [ion binding]; other site
318586004052	Helix-turn-helix domain; Region: HTH_17; pfam12728
318586004053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586004054	S-adenosylmethionine binding site [chemical binding]; other site
318586004055	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
318586004056	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
318586004057	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586004058	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586004059	Walker A/P-loop; other site
318586004060	ATP binding site [chemical binding]; other site
318586004061	Q-loop/lid; other site
318586004062	ABC transporter signature motif; other site
318586004063	Walker B; other site
318586004064	D-loop; other site
318586004065	H-loop/switch region; other site
318586004066	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
318586004067	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586004068	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586004069	dimer interface [polypeptide binding]; other site
318586004070	putative PBP binding regions; other site
318586004071	ABC-ATPase subunit  interface; other site
318586004072	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
318586004073	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
318586004074	putative ligand binding residues [chemical binding]; other site
318586004075	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
318586004076	tetramer interface [polypeptide binding]; other site
318586004077	active site
318586004078	Mg2+/Mn2+ binding site [ion binding]; other site
318586004079	isocitrate lyase; Region: PLN02892
318586004080	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
318586004081	malate synthase A; Region: malate_syn_A; TIGR01344
318586004082	active site
318586004083	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586004084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586004085	non-specific DNA binding site [nucleotide binding]; other site
318586004086	salt bridge; other site
318586004087	sequence-specific DNA binding site [nucleotide binding]; other site
318586004088	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
318586004089	Domain of unknown function (DUF955); Region: DUF955; pfam06114
318586004090	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
318586004091	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586004092	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
318586004093	intersubunit interface [polypeptide binding]; other site
318586004094	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
318586004095	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004096	N-terminal plug; other site
318586004097	ligand-binding site [chemical binding]; other site
318586004098	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
318586004099	putative active site [active]
318586004100	putative metal binding site [ion binding]; other site
318586004101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
318586004102	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
318586004103	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
318586004104	active site
318586004105	metal binding site [ion binding]; metal-binding site
318586004106	lipoyl synthase; Provisional; Region: PRK05481
318586004107	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586004108	FeS/SAM binding site; other site
318586004109	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
318586004110	catalytic triad [active]
318586004111	dimer interface [polypeptide binding]; other site
318586004112	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
318586004113	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
318586004114	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
318586004115	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
318586004116	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
318586004117	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
318586004118	protein binding site [polypeptide binding]; other site
318586004119	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
318586004120	protein binding site [polypeptide binding]; other site
318586004121	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
318586004122	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
318586004123	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
318586004124	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
318586004125	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
318586004126	TSCPD domain; Region: TSCPD; pfam12637
318586004127	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
318586004128	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
318586004129	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
318586004130	MgtE intracellular N domain; Region: MgtE_N; smart00924
318586004131	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
318586004132	Divalent cation transporter; Region: MgtE; pfam01769
318586004133	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
318586004134	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
318586004135	active site
318586004136	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586004137	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586004138	non-specific DNA binding site [nucleotide binding]; other site
318586004139	salt bridge; other site
318586004140	sequence-specific DNA binding site [nucleotide binding]; other site
318586004141	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
318586004142	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
318586004143	NAD(P) binding site [chemical binding]; other site
318586004144	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
318586004145	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
318586004146	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
318586004147	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
318586004148	putative GSH binding site [chemical binding]; other site
318586004149	catalytic residues [active]
318586004150	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
318586004151	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
318586004152	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586004153	catalytic residue [active]
318586004154	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
318586004155	catalytic triad [active]
318586004156	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
318586004157	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
318586004158	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
318586004159	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586004160	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
318586004161	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
318586004162	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
318586004163	Zn2+ binding site [ion binding]; other site
318586004164	Mg2+ binding site [ion binding]; other site
318586004165	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
318586004166	synthetase active site [active]
318586004167	NTP binding site [chemical binding]; other site
318586004168	metal binding site [ion binding]; metal-binding site
318586004169	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
318586004170	ACT domain; Region: ACT_4; pfam13291
318586004171	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
318586004172	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
318586004173	catalytic center binding site [active]
318586004174	ATP binding site [chemical binding]; other site
318586004175	Uncharacterized conserved protein [Function unknown]; Region: COG1432
318586004176	LabA_like proteins; Region: LabA; cd10911
318586004177	putative metal binding site [ion binding]; other site
318586004178	hypothetical protein; Validated; Region: PRK09039
318586004179	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586004180	ligand binding site [chemical binding]; other site
318586004181	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
318586004182	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
318586004183	putative active site pocket [active]
318586004184	dimerization interface [polypeptide binding]; other site
318586004185	putative catalytic residue [active]
318586004186	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
318586004187	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
318586004188	prephenate dehydrogenase; Validated; Region: PRK08507
318586004189	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
318586004190	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586004191	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586004192	homodimer interface [polypeptide binding]; other site
318586004193	catalytic residue [active]
318586004194	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
318586004195	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
318586004196	catalytic residues [active]
318586004197	central insert; other site
318586004198	heme exporter protein CcmC; Region: ccmC; TIGR01191
318586004199	heme exporter protein CcmB; Region: ccmB; TIGR01190
318586004200	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
318586004201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004202	Walker A/P-loop; other site
318586004203	ATP binding site [chemical binding]; other site
318586004204	Q-loop/lid; other site
318586004205	ABC transporter signature motif; other site
318586004206	Walker B; other site
318586004207	D-loop; other site
318586004208	H-loop/switch region; other site
318586004209	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
318586004210	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
318586004211	Protein export membrane protein; Region: SecD_SecF; pfam02355
318586004212	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
318586004213	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
318586004214	Preprotein translocase subunit; Region: YajC; pfam02699
318586004215	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
318586004216	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
318586004217	homodimer interface [polypeptide binding]; other site
318586004218	metal binding site [ion binding]; metal-binding site
318586004219	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
318586004220	homodimer interface [polypeptide binding]; other site
318586004221	active site
318586004222	putative chemical substrate binding site [chemical binding]; other site
318586004223	metal binding site [ion binding]; metal-binding site
318586004224	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
318586004225	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
318586004226	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
318586004227	FMN binding site [chemical binding]; other site
318586004228	active site
318586004229	catalytic residues [active]
318586004230	substrate binding site [chemical binding]; other site
318586004231	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586004232	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
318586004233	active site
318586004234	DNA binding site [nucleotide binding]
318586004235	Int/Topo IB signature motif; other site
318586004236	Predicted transcriptional regulator [Transcription]; Region: COG1959
318586004237	Transcriptional regulator; Region: Rrf2; pfam02082
318586004238	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
318586004239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
318586004240	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586004241	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586004242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004243	Walker A/P-loop; other site
318586004244	ATP binding site [chemical binding]; other site
318586004245	Q-loop/lid; other site
318586004246	ABC transporter signature motif; other site
318586004247	Walker B; other site
318586004248	D-loop; other site
318586004249	H-loop/switch region; other site
318586004250	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586004251	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586004252	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004253	Walker A/P-loop; other site
318586004254	ATP binding site [chemical binding]; other site
318586004255	Q-loop/lid; other site
318586004256	ABC transporter signature motif; other site
318586004257	Walker B; other site
318586004258	D-loop; other site
318586004259	H-loop/switch region; other site
318586004260	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004261	N-terminal plug; other site
318586004262	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586004263	ligand-binding site [chemical binding]; other site
318586004264	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586004265	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
318586004266	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586004267	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586004268	DNA-binding site [nucleotide binding]; DNA binding site
318586004269	FCD domain; Region: FCD; pfam07729
318586004270	BioY family; Region: BioY; pfam02632
318586004271	biotin synthase; Region: bioB; TIGR00433
318586004272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586004273	FeS/SAM binding site; other site
318586004274	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
318586004275	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
318586004276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586004277	DNA-binding site [nucleotide binding]; DNA binding site
318586004278	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586004279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586004280	homodimer interface [polypeptide binding]; other site
318586004281	catalytic residue [active]
318586004282	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
318586004283	catalytic triad [active]
318586004284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
318586004285	MOSC domain; Region: MOSC; pfam03473
318586004286	3-alpha domain; Region: 3-alpha; pfam03475
318586004287	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
318586004288	pyridoxal binding site [chemical binding]; other site
318586004289	dimer interface [polypeptide binding]; other site
318586004290	ATP binding site [chemical binding]; other site
318586004291	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
318586004292	Part of AAA domain; Region: AAA_19; pfam13245
318586004293	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
318586004294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004295	Walker A/P-loop; other site
318586004296	ATP binding site [chemical binding]; other site
318586004297	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
318586004298	putative active site [active]
318586004299	putative metal-binding site [ion binding]; other site
318586004300	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586004301	CoenzymeA binding site [chemical binding]; other site
318586004302	subunit interaction site [polypeptide binding]; other site
318586004303	PHB binding site; other site
318586004304	SnoaL-like domain; Region: SnoaL_2; pfam12680
318586004305	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
318586004306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586004307	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586004308	putative substrate translocation pore; other site
318586004309	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
318586004310	substrate binding site [chemical binding]; other site
318586004311	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
318586004312	Predicted ATPase [General function prediction only]; Region: COG3911
318586004313	AAA domain; Region: AAA_28; pfam13521
318586004314	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
318586004315	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
318586004316	GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323
318586004317	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
318586004318	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
318586004319	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
318586004320	putative dimer interface [polypeptide binding]; other site
318586004321	N-terminal domain interface [polypeptide binding]; other site
318586004322	putative substrate binding pocket (H-site) [chemical binding]; other site
318586004323	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
318586004324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586004325	putative substrate translocation pore; other site
318586004326	Predicted transcriptional regulators [Transcription]; Region: COG1733
318586004327	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
318586004328	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
318586004329	Cupin domain; Region: Cupin_2; cl17218
318586004330	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
318586004331	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
318586004332	putative catalytic residue [active]
318586004333	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586004334	Coenzyme A binding pocket [chemical binding]; other site
318586004335	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
318586004336	Coenzyme A binding pocket [chemical binding]; other site
318586004337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586004338	Coenzyme A binding pocket [chemical binding]; other site
318586004339	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586004340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586004341	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
318586004342	dimerization interface [polypeptide binding]; other site
318586004343	substrate binding pocket [chemical binding]; other site
318586004344	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
318586004345	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
318586004346	homodimer interface [polypeptide binding]; other site
318586004347	substrate-cofactor binding pocket; other site
318586004348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586004349	catalytic residue [active]
318586004350	hypothetical protein; Provisional; Region: PRK10621
318586004351	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586004352	Helix-turn-helix domain; Region: HTH_18; pfam12833
318586004353	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
318586004354	Serine hydrolase; Region: Ser_hydrolase; pfam06821
318586004355	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586004356	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586004357	putative DNA binding site [nucleotide binding]; other site
318586004358	putative Zn2+ binding site [ion binding]; other site
318586004359	AsnC family; Region: AsnC_trans_reg; pfam01037
318586004360	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
318586004361	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586004362	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586004363	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
318586004364	dimerization interface [polypeptide binding]; other site
318586004365	substrate binding pocket [chemical binding]; other site
318586004366	TPR repeat; Region: TPR_11; pfam13414
318586004367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586004368	binding surface
318586004369	TPR motif; other site
318586004370	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
318586004371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586004372	S-adenosylmethionine binding site [chemical binding]; other site
318586004373	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
318586004374	putative active site [active]
318586004375	putative catalytic site [active]
318586004376	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
318586004377	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
318586004378	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
318586004379	VirB7 interaction site; other site
318586004380	conjugal transfer protein TrbF; Provisional; Region: PRK13872
318586004381	conjugal transfer protein TrbL; Provisional; Region: PRK13875
318586004382	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
318586004383	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
318586004384	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
318586004385	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
318586004386	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
318586004387	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
318586004388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004389	Walker A/P-loop; other site
318586004390	ATP binding site [chemical binding]; other site
318586004391	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004392	Walker B; other site
318586004393	D-loop; other site
318586004394	H-loop/switch region; other site
318586004395	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
318586004396	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
318586004397	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
318586004398	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
318586004399	Walker A motif; other site
318586004400	ATP binding site [chemical binding]; other site
318586004401	Walker B motif; other site
318586004402	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586004403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586004404	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586004405	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004406	N-terminal plug; other site
318586004407	ligand-binding site [chemical binding]; other site
318586004408	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586004409	S-adenosylmethionine binding site [chemical binding]; other site
318586004410	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
318586004411	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586004412	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
318586004413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004414	Walker A/P-loop; other site
318586004415	ATP binding site [chemical binding]; other site
318586004416	Q-loop/lid; other site
318586004417	ABC transporter signature motif; other site
318586004418	Walker B; other site
318586004419	D-loop; other site
318586004420	H-loop/switch region; other site
318586004421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586004422	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586004423	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586004424	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004425	Walker A/P-loop; other site
318586004426	ATP binding site [chemical binding]; other site
318586004427	Q-loop/lid; other site
318586004428	ABC transporter signature motif; other site
318586004429	Walker B; other site
318586004430	D-loop; other site
318586004431	H-loop/switch region; other site
318586004432	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586004433	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586004434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586004435	Walker A/P-loop; other site
318586004436	ATP binding site [chemical binding]; other site
318586004437	Q-loop/lid; other site
318586004438	ABC transporter signature motif; other site
318586004439	Walker B; other site
318586004440	D-loop; other site
318586004441	H-loop/switch region; other site
318586004442	hypothetical protein; Provisional; Region: PRK07588
318586004443	hypothetical protein; Provisional; Region: PRK07236
318586004444	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586004445	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586004446	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004447	N-terminal plug; other site
318586004448	ligand-binding site [chemical binding]; other site
318586004449	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
318586004450	muropeptide transporter; Validated; Region: ampG; cl17669
318586004451	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586004452	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586004453	muropeptide transporter; Validated; Region: ampG; cl17669
318586004454	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586004455	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004456	N-terminal plug; other site
318586004457	ligand-binding site [chemical binding]; other site
318586004458	Helix-turn-helix domain; Region: HTH_18; pfam12833
318586004459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586004460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
318586004461	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
318586004462	hypothetical protein; Provisional; Region: PRK06185
318586004463	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586004464	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
318586004465	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
318586004466	Walker A motif; other site
318586004467	ATP binding site [chemical binding]; other site
318586004468	Walker B motif; other site
318586004469	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
318586004470	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
318586004471	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586004472	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586004473	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586004474	catalytic residue [active]
318586004475	Protein of unknown function (DUF736); Region: DUF736; pfam05284
318586004476	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
318586004477	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
318586004478	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
318586004479	Replication initiator protein A; Region: RPA; pfam10134
318586004480	Helix-turn-helix domain; Region: HTH_17; pfam12728
318586004481	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
318586004482	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
318586004483	non-specific DNA binding site [nucleotide binding]; other site
318586004484	salt bridge; other site
318586004485	sequence-specific DNA binding site [nucleotide binding]; other site
318586004486	Uncharacterized conserved protein [Function unknown]; Region: COG5489
318586004487	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
318586004488	HNH endonuclease; Region: HNH_2; pfam13391
318586004489	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
318586004490	Methyltransferase domain; Region: Methyltransf_26; pfam13659
318586004491	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
318586004492	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586004493	ATP binding site [chemical binding]; other site
318586004494	putative Mg++ binding site [ion binding]; other site
318586004495	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586004496	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
318586004497	nucleotide binding region [chemical binding]; other site
318586004498	ATP-binding site [chemical binding]; other site
318586004499	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
318586004500	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586004501	ATP binding site [chemical binding]; other site
318586004502	putative Mg++ binding site [ion binding]; other site
318586004503	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
318586004504	Protein of unknown function DUF262; Region: DUF262; pfam03235
318586004505	Uncharacterized conserved protein [Function unknown]; Region: COG1479
318586004506	Uncharacterized conserved protein [Function unknown]; Region: COG3472
318586004507	Predicted transcriptional regulator [Transcription]; Region: COG2378
318586004508	WYL domain; Region: WYL; pfam13280
318586004509	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
318586004510	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
318586004511	active site
318586004512	metal binding site [ion binding]; metal-binding site
318586004513	interdomain interaction site; other site
318586004514	Methyltransferase domain; Region: Methyltransf_26; pfam13659
318586004515	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
318586004516	Helicase_C-like; Region: Helicase_C_4; pfam13871
318586004517	Fic family protein [Function unknown]; Region: COG3177
318586004518	Fic/DOC family; Region: Fic; pfam02661
318586004519	ParB-like nuclease domain; Region: ParBc; pfam02195
318586004520	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
318586004521	MPN+ (JAMM) motif; other site
318586004522	Zinc-binding site [ion binding]; other site
318586004523	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
318586004524	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
318586004525	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
318586004526	H-NS histone family; Region: Histone_HNS; pfam00816
318586004527	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
318586004528	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
318586004529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586004530	sequence-specific DNA binding site [nucleotide binding]; other site
318586004531	salt bridge; other site
318586004532	HipA N-terminal domain; Region: Couple_hipA; pfam13657
318586004533	HipA-like N-terminal domain; Region: HipA_N; pfam07805
318586004534	HipA-like C-terminal domain; Region: HipA_C; pfam07804
318586004535	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
318586004536	Protein of unknown function, DUF481; Region: DUF481; pfam04338
318586004537	transcription antitermination factor NusB; Region: nusB; TIGR01951
318586004538	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
318586004539	homopentamer interface [polypeptide binding]; other site
318586004540	active site
318586004541	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
318586004542	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
318586004543	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
318586004544	dimerization interface [polypeptide binding]; other site
318586004545	active site
318586004546	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
318586004547	Lumazine binding domain; Region: Lum_binding; pfam00677
318586004548	Lumazine binding domain; Region: Lum_binding; pfam00677
318586004549	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
318586004550	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
318586004551	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
318586004552	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
318586004553	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
318586004554	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
318586004555	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
318586004556	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
318586004557	catalytic motif [active]
318586004558	Zn binding site [ion binding]; other site
318586004559	RibD C-terminal domain; Region: RibD_C; cl17279
318586004560	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
318586004561	ATP cone domain; Region: ATP-cone; pfam03477
318586004562	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
318586004563	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586004564	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
318586004565	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
318586004566	cobalamin synthase; Reviewed; Region: cobS; PRK00235
318586004567	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
318586004568	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
318586004569	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
318586004570	putative dimer interface [polypeptide binding]; other site
318586004571	active site pocket [active]
318586004572	putative cataytic base [active]
318586004573	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
318586004574	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
318586004575	homotrimer interface [polypeptide binding]; other site
318586004576	Walker A motif; other site
318586004577	GTP binding site [chemical binding]; other site
318586004578	Walker B motif; other site
318586004579	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
318586004580	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
318586004581	peptide binding site [polypeptide binding]; other site
318586004582	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
318586004583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586004584	dimer interface [polypeptide binding]; other site
318586004585	conserved gate region; other site
318586004586	putative PBP binding loops; other site
318586004587	ABC-ATPase subunit interface; other site
318586004588	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
318586004589	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
318586004590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586004591	dimer interface [polypeptide binding]; other site
318586004592	conserved gate region; other site
318586004593	putative PBP binding loops; other site
318586004594	ABC-ATPase subunit interface; other site
318586004595	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
318586004596	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004597	Walker A/P-loop; other site
318586004598	ATP binding site [chemical binding]; other site
318586004599	Q-loop/lid; other site
318586004600	ABC transporter signature motif; other site
318586004601	Walker B; other site
318586004602	D-loop; other site
318586004603	H-loop/switch region; other site
318586004604	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586004605	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
318586004606	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004607	Walker A/P-loop; other site
318586004608	ATP binding site [chemical binding]; other site
318586004609	Q-loop/lid; other site
318586004610	ABC transporter signature motif; other site
318586004611	Walker B; other site
318586004612	D-loop; other site
318586004613	H-loop/switch region; other site
318586004614	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
318586004615	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
318586004616	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
318586004617	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586004618	active site
318586004619	nucleotide binding site [chemical binding]; other site
318586004620	HIGH motif; other site
318586004621	KMSKS motif; other site
318586004622	tellurite resistance protein terB; Region: terB; cd07176
318586004623	putative metal binding site [ion binding]; other site
318586004624	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
318586004625	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
318586004626	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
318586004627	active site
318586004628	(T/H)XGH motif; other site
318586004629	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
318586004630	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
318586004631	Potassium binding sites [ion binding]; other site
318586004632	Cesium cation binding sites [ion binding]; other site
318586004633	OpgC protein; Region: OpgC_C; pfam10129
318586004634	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
318586004635	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
318586004636	Ligand binding site; other site
318586004637	DXD motif; other site
318586004638	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
318586004639	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
318586004640	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586004641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586004642	active site
318586004643	phosphorylation site [posttranslational modification]
318586004644	intermolecular recognition site; other site
318586004645	dimerization interface [polypeptide binding]; other site
318586004646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586004647	DNA binding site [nucleotide binding]
318586004648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586004649	ATP binding site [chemical binding]; other site
318586004650	Mg2+ binding site [ion binding]; other site
318586004651	G-X-G motif; other site
318586004652	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
318586004653	excinuclease ABC subunit B; Provisional; Region: PRK05298
318586004654	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586004655	ATP binding site [chemical binding]; other site
318586004656	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586004657	nucleotide binding region [chemical binding]; other site
318586004658	ATP-binding site [chemical binding]; other site
318586004659	Ultra-violet resistance protein B; Region: UvrB; pfam12344
318586004660	UvrB/uvrC motif; Region: UVR; pfam02151
318586004661	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
318586004662	AAA domain; Region: AAA_31; pfam13614
318586004663	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586004664	P-loop; other site
318586004665	Magnesium ion binding site [ion binding]; other site
318586004666	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
318586004667	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
318586004668	active site
318586004669	dimer interface [polypeptide binding]; other site
318586004670	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
318586004671	exopolyphosphatase; Region: exo_poly_only; TIGR03706
318586004672	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
318586004673	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
318586004674	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
318586004675	putative active site [active]
318586004676	putative domain interface [polypeptide binding]; other site
318586004677	catalytic site [active]
318586004678	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
318586004679	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
318586004680	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
318586004681	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
318586004682	ABC-ATPase subunit  interface; other site
318586004683	dimer interface [polypeptide binding]; other site
318586004684	putative PBP binding regions; other site
318586004685	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
318586004686	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586004687	intersubunit interface [polypeptide binding]; other site
318586004688	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
318586004689	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586004690	putative C-terminal domain interface [polypeptide binding]; other site
318586004691	putative GSH binding site (G-site) [chemical binding]; other site
318586004692	putative dimer interface [polypeptide binding]; other site
318586004693	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586004694	N-terminal domain interface [polypeptide binding]; other site
318586004695	dimer interface [polypeptide binding]; other site
318586004696	substrate binding pocket (H-site) [chemical binding]; other site
318586004697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586004698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586004699	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586004700	dimerization interface [polypeptide binding]; other site
318586004701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586004702	putative substrate translocation pore; other site
318586004703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586004704	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004705	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
318586004706	N-terminal plug; other site
318586004707	ligand-binding site [chemical binding]; other site
318586004708	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
318586004709	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586004710	E3 interaction surface; other site
318586004711	lipoyl attachment site [posttranslational modification]; other site
318586004712	e3 binding domain; Region: E3_binding; pfam02817
318586004713	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
318586004714	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
318586004715	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
318586004716	tetramer interface [polypeptide binding]; other site
318586004717	TPP-binding site [chemical binding]; other site
318586004718	heterodimer interface [polypeptide binding]; other site
318586004719	phosphorylation loop region [posttranslational modification]
318586004720	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
318586004721	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
318586004722	PYR/PP interface [polypeptide binding]; other site
318586004723	dimer interface [polypeptide binding]; other site
318586004724	TPP binding site [chemical binding]; other site
318586004725	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586004726	Flavoprotein; Region: Flavoprotein; pfam02441
318586004727	Methyltransferase domain; Region: Methyltransf_23; pfam13489
318586004728	Methyltransferase domain; Region: Methyltransf_12; pfam08242
318586004729	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586004730	NAD(P) binding site [chemical binding]; other site
318586004731	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
318586004732	substrate binding site [chemical binding]; other site
318586004733	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520
318586004734	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
318586004735	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586004736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
318586004737	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586004738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
318586004739	ABC-ATPase subunit interface; other site
318586004740	putative PBP binding loops; other site
318586004741	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586004742	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004743	Walker A/P-loop; other site
318586004744	ATP binding site [chemical binding]; other site
318586004745	Q-loop/lid; other site
318586004746	ABC transporter signature motif; other site
318586004747	Walker B; other site
318586004748	D-loop; other site
318586004749	H-loop/switch region; other site
318586004750	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004751	Walker A/P-loop; other site
318586004752	ATP binding site [chemical binding]; other site
318586004753	Q-loop/lid; other site
318586004754	ABC transporter signature motif; other site
318586004755	Walker B; other site
318586004756	D-loop; other site
318586004757	H-loop/switch region; other site
318586004758	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
318586004759	putative active site pocket [active]
318586004760	dimerization interface [polypeptide binding]; other site
318586004761	putative catalytic residue [active]
318586004762	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586004763	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
318586004764	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
318586004765	active site
318586004766	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586004767	active site
318586004768	Prephenate dehydratase; Region: PDT; pfam00800
318586004769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
318586004770	Transposase; Region: HTH_Tnp_1; cl17663
318586004771	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
318586004772	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
318586004773	Flagellar protein FlaF; Region: FlaF; pfam07309
318586004774	flagellin; Reviewed; Region: PRK12687
318586004775	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
318586004776	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
318586004777	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813
318586004778	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
318586004779	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
318586004780	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
318586004781	Transposase; Region: HTH_Tnp_1; pfam01527
318586004782	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
318586004783	PQQ-like domain; Region: PQQ_2; pfam13360
318586004784	Trp docking motif [polypeptide binding]; other site
318586004785	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
318586004786	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
318586004787	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004788	N-terminal plug; other site
318586004789	ligand-binding site [chemical binding]; other site
318586004790	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
318586004791	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586004792	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586004793	DNA binding residues [nucleotide binding]
318586004794	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
318586004795	FecR protein; Region: FecR; pfam04773
318586004796	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
318586004797	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586004798	N-terminal plug; other site
318586004799	ligand-binding site [chemical binding]; other site
318586004800	carboxylate-amine ligase; Provisional; Region: PRK13515
318586004801	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
318586004802	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
318586004803	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
318586004804	E-class dimer interface [polypeptide binding]; other site
318586004805	P-class dimer interface [polypeptide binding]; other site
318586004806	active site
318586004807	Cu2+ binding site [ion binding]; other site
318586004808	Zn2+ binding site [ion binding]; other site
318586004809	PAS fold; Region: PAS_4; pfam08448
318586004810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
318586004811	HWE histidine kinase; Region: HWE_HK; smart00911
318586004812	Isochorismatase family; Region: Isochorismatase; pfam00857
318586004813	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
318586004814	catalytic triad [active]
318586004815	conserved cis-peptide bond; other site
318586004816	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
318586004817	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; pfam01515
318586004818	Predicted membrane protein [Function unknown]; Region: COG2855
318586004819	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
318586004820	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586004821	PYR/PP interface [polypeptide binding]; other site
318586004822	dimer interface [polypeptide binding]; other site
318586004823	TPP binding site [chemical binding]; other site
318586004824	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586004825	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
318586004826	TPP-binding site [chemical binding]; other site
318586004827	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
318586004828	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586004829	SnoaL-like domain; Region: SnoaL_2; pfam12680
318586004830	DctM-like transporters; Region: DctM; pfam06808
318586004831	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586004832	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586004833	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586004834	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586004835	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
318586004836	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586004837	DNA-binding site [nucleotide binding]; DNA binding site
318586004838	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586004839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586004840	homodimer interface [polypeptide binding]; other site
318586004841	catalytic residue [active]
318586004842	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
318586004843	active site 1 [active]
318586004844	dimer interface [polypeptide binding]; other site
318586004845	active site 2 [active]
318586004846	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
318586004847	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
318586004848	dimer interface [polypeptide binding]; other site
318586004849	active site
318586004850	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
318586004851	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
318586004852	NAD binding site [chemical binding]; other site
318586004853	homotetramer interface [polypeptide binding]; other site
318586004854	homodimer interface [polypeptide binding]; other site
318586004855	substrate binding site [chemical binding]; other site
318586004856	active site
318586004857	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586004858	Transglycosylase SLT domain; Region: SLT_2; pfam13406
318586004859	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586004860	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586004861	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586004862	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
318586004863	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
318586004864	motif 1; other site
318586004865	dimer interface [polypeptide binding]; other site
318586004866	active site
318586004867	motif 2; other site
318586004868	motif 3; other site
318586004869	elongation factor P; Validated; Region: PRK00529
318586004870	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
318586004871	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
318586004872	RNA binding site [nucleotide binding]; other site
318586004873	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
318586004874	RNA binding site [nucleotide binding]; other site
318586004875	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
318586004876	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
318586004877	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
318586004878	active site
318586004879	oligomerization interface [polypeptide binding]; other site
318586004880	metal binding site [ion binding]; metal-binding site
318586004881	pantoate--beta-alanine ligase; Region: panC; TIGR00018
318586004882	Pantoate-beta-alanine ligase; Region: PanC; cd00560
318586004883	active site
318586004884	ATP-binding site [chemical binding]; other site
318586004885	pantoate-binding site; other site
318586004886	HXXH motif; other site
318586004887	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586004888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
318586004889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586004890	ATP binding site [chemical binding]; other site
318586004891	Mg2+ binding site [ion binding]; other site
318586004892	G-X-G motif; other site
318586004893	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586004894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586004895	active site
318586004896	phosphorylation site [posttranslational modification]
318586004897	intermolecular recognition site; other site
318586004898	dimerization interface [polypeptide binding]; other site
318586004899	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586004900	DNA binding site [nucleotide binding]
318586004901	Predicted membrane protein [Function unknown]; Region: COG3212
318586004902	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
318586004903	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
318586004904	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
318586004905	iron-sulfur cluster [ion binding]; other site
318586004906	[2Fe-2S] cluster binding site [ion binding]; other site
318586004907	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
318586004908	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
318586004909	dimer interface [polypeptide binding]; other site
318586004910	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
318586004911	active site
318586004912	Fe binding site [ion binding]; other site
318586004913	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586004914	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586004915	putative DNA binding site [nucleotide binding]; other site
318586004916	putative Zn2+ binding site [ion binding]; other site
318586004917	AsnC family; Region: AsnC_trans_reg; pfam01037
318586004918	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
318586004919	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586004920	FeS/SAM binding site; other site
318586004921	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
318586004922	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004923	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
318586004924	Walker A/P-loop; other site
318586004925	ATP binding site [chemical binding]; other site
318586004926	Q-loop/lid; other site
318586004927	ABC transporter signature motif; other site
318586004928	Walker B; other site
318586004929	D-loop; other site
318586004930	H-loop/switch region; other site
318586004931	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586004932	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586004933	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
318586004934	Walker A/P-loop; other site
318586004935	ATP binding site [chemical binding]; other site
318586004936	Q-loop/lid; other site
318586004937	ABC transporter signature motif; other site
318586004938	Walker B; other site
318586004939	D-loop; other site
318586004940	H-loop/switch region; other site
318586004941	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
318586004942	dipeptide transporter; Provisional; Region: PRK10913
318586004943	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
318586004944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586004945	putative PBP binding loops; other site
318586004946	dimer interface [polypeptide binding]; other site
318586004947	ABC-ATPase subunit interface; other site
318586004948	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586004949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586004950	putative PBP binding loops; other site
318586004951	dimer interface [polypeptide binding]; other site
318586004952	ABC-ATPase subunit interface; other site
318586004953	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586004954	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
318586004955	peptide binding site [polypeptide binding]; other site
318586004956	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
318586004957	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
318586004958	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
318586004959	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586004960	PYR/PP interface [polypeptide binding]; other site
318586004961	dimer interface [polypeptide binding]; other site
318586004962	TPP binding site [chemical binding]; other site
318586004963	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586004964	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
318586004965	TPP-binding site [chemical binding]; other site
318586004966	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586004967	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
318586004968	substrate binding site [chemical binding]; other site
318586004969	ATP binding site [chemical binding]; other site
318586004970	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
318586004971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
318586004972	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
318586004973	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586004974	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586004975	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
318586004976	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
318586004977	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586004978	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586004979	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
318586004980	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
318586004981	putative ligand binding site [chemical binding]; other site
318586004982	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586004983	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586004984	TM-ABC transporter signature motif; other site
318586004985	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
318586004986	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586004987	Walker A/P-loop; other site
318586004988	ATP binding site [chemical binding]; other site
318586004989	Q-loop/lid; other site
318586004990	ABC transporter signature motif; other site
318586004991	Walker B; other site
318586004992	D-loop; other site
318586004993	H-loop/switch region; other site
318586004994	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586004995	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
318586004996	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
318586004997	putative ligand binding site [chemical binding]; other site
318586004998	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
318586004999	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586005000	DNA binding site [nucleotide binding]
318586005001	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
318586005002	putative ligand binding site [chemical binding]; other site
318586005003	Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028
318586005004	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586005005	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
318586005006	conserved cys residue [active]
318586005007	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586005008	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586005009	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
318586005010	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
318586005011	heme-binding site [chemical binding]; other site
318586005012	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
318586005013	FAD binding pocket [chemical binding]; other site
318586005014	FAD binding motif [chemical binding]; other site
318586005015	phosphate binding motif [ion binding]; other site
318586005016	beta-alpha-beta structure motif; other site
318586005017	NAD binding pocket [chemical binding]; other site
318586005018	Heme binding  pocket [chemical binding]; other site
318586005019	Transcriptional regulator; Region: Rrf2; cl17282
318586005020	Rrf2 family protein; Region: rrf2_super; TIGR00738
318586005021	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586005022	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586005023	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
318586005024	dimerization interface [polypeptide binding]; other site
318586005025	substrate binding pocket [chemical binding]; other site
318586005026	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
318586005027	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586005028	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
318586005029	active site
318586005030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586005031	metabolite-proton symporter; Region: 2A0106; TIGR00883
318586005032	putative substrate translocation pore; other site
318586005033	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586005034	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586005035	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586005036	dimerization interface [polypeptide binding]; other site
318586005037	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
318586005038	metal binding site [ion binding]; metal-binding site
318586005039	active site
318586005040	phosphoribulokinase; Provisional; Region: PRK15453
318586005041	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
318586005042	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
318586005043	TPP-binding site [chemical binding]; other site
318586005044	dimer interface [polypeptide binding]; other site
318586005045	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
318586005046	PYR/PP interface [polypeptide binding]; other site
318586005047	dimer interface [polypeptide binding]; other site
318586005048	TPP binding site [chemical binding]; other site
318586005049	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586005050	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
318586005051	intersubunit interface [polypeptide binding]; other site
318586005052	active site
318586005053	zinc binding site [ion binding]; other site
318586005054	Na+ binding site [ion binding]; other site
318586005055	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
318586005056	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
318586005057	homodimer interface [polypeptide binding]; other site
318586005058	active site
318586005059	heterodimer interface [polypeptide binding]; other site
318586005060	catalytic residue [active]
318586005061	metal binding site [ion binding]; metal-binding site
318586005062	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
318586005063	multimerization interface [polypeptide binding]; other site
318586005064	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
318586005065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586005066	Walker A motif; other site
318586005067	ATP binding site [chemical binding]; other site
318586005068	Walker B motif; other site
318586005069	arginine finger; other site
318586005070	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586005071	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
318586005072	Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098
318586005073	Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099
318586005074	Domain of unknown function (DUF1928); Region: DUF1928; pfam09100
318586005075	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
318586005076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586005077	FeS/SAM binding site; other site
318586005078	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
318586005079	Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992
318586005080	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
318586005081	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
318586005082	active site
318586005083	catalytic residues [active]
318586005084	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
318586005085	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586005086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586005087	Walker A/P-loop; other site
318586005088	ATP binding site [chemical binding]; other site
318586005089	Q-loop/lid; other site
318586005090	ABC transporter signature motif; other site
318586005091	Walker B; other site
318586005092	D-loop; other site
318586005093	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
318586005094	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586005095	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586005096	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586005097	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
318586005098	NAD(P) binding site [chemical binding]; other site
318586005099	catalytic residues [active]
318586005100	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
318586005101	choline dehydrogenase; Validated; Region: PRK02106
318586005102	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
318586005103	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586005104	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586005105	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586005106	TM-ABC transporter signature motif; other site
318586005107	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586005108	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586005109	TM-ABC transporter signature motif; other site
318586005110	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586005111	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586005112	Walker A/P-loop; other site
318586005113	ATP binding site [chemical binding]; other site
318586005114	Q-loop/lid; other site
318586005115	ABC transporter signature motif; other site
318586005116	Walker B; other site
318586005117	D-loop; other site
318586005118	H-loop/switch region; other site
318586005119	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586005120	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586005121	Walker A/P-loop; other site
318586005122	ATP binding site [chemical binding]; other site
318586005123	Q-loop/lid; other site
318586005124	ABC transporter signature motif; other site
318586005125	Walker B; other site
318586005126	D-loop; other site
318586005127	H-loop/switch region; other site
318586005128	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586005129	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
318586005130	putative ligand binding site [chemical binding]; other site
318586005131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586005132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586005133	LysR substrate binding domain; Region: LysR_substrate; pfam03466
318586005134	dimerization interface [polypeptide binding]; other site
318586005135	malonyl-CoA synthase; Validated; Region: PRK07514
318586005136	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
318586005137	acyl-activating enzyme (AAE) consensus motif; other site
318586005138	active site
318586005139	AMP binding site [chemical binding]; other site
318586005140	CoA binding site [chemical binding]; other site
318586005141	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
318586005142	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
318586005143	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586005144	DNA-binding site [nucleotide binding]; DNA binding site
318586005145	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
318586005146	FCD domain; Region: FCD; pfam07729
318586005147	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
318586005148	putative active site [active]
318586005149	putative metal binding residues [ion binding]; other site
318586005150	putative triphosphate binding site [ion binding]; other site
318586005151	signature motif; other site
318586005152	CHAD domain; Region: CHAD; pfam05235
318586005153	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
318586005154	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
318586005155	hexamer interface [polypeptide binding]; other site
318586005156	ligand binding site [chemical binding]; other site
318586005157	putative active site [active]
318586005158	NAD(P) binding site [chemical binding]; other site
318586005159	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
318586005160	high affinity sulphate transporter 1; Region: sulP; TIGR00815
318586005161	Sulfate transporter family; Region: Sulfate_transp; pfam00916
318586005162	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
318586005163	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
318586005164	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
318586005165	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
318586005166	putative dimer interface [polypeptide binding]; other site
318586005167	N-terminal domain interface [polypeptide binding]; other site
318586005168	putative substrate binding pocket (H-site) [chemical binding]; other site
318586005169	Iron permease FTR1 family; Region: FTR1; cl00475
318586005170	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
318586005171	Imelysin; Region: Peptidase_M75; pfam09375
318586005172	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
318586005173	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
318586005174	Imelysin; Region: Peptidase_M75; pfam09375
318586005175	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586005176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586005177	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
318586005178	dimerization interface [polypeptide binding]; other site
318586005179	substrate binding pocket [chemical binding]; other site
318586005180	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
318586005181	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586005182	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
318586005183	active site
318586005184	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586005185	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586005186	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
318586005187	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
318586005188	putative active site [active]
318586005189	dimerization interface [polypeptide binding]; other site
318586005190	putative tRNAtyr binding site [nucleotide binding]; other site
318586005191	helicase 45; Provisional; Region: PTZ00424
318586005192	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
318586005193	ATP binding site [chemical binding]; other site
318586005194	Mg++ binding site [ion binding]; other site
318586005195	motif III; other site
318586005196	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586005197	nucleotide binding region [chemical binding]; other site
318586005198	ATP-binding site [chemical binding]; other site
318586005199	thymidine kinase; Provisional; Region: PRK04296
318586005200	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
318586005201	YceI-like domain; Region: YceI; pfam04264
318586005202	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
318586005203	active site
318586005204	multimer interface [polypeptide binding]; other site
318586005205	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
318586005206	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586005207	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586005208	ABC transporter; Region: ABC_tran_2; pfam12848
318586005209	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586005210	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
318586005211	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
318586005212	maltose O-acetyltransferase; Provisional; Region: PRK10092
318586005213	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
318586005214	active site
318586005215	substrate binding site [chemical binding]; other site
318586005216	trimer interface [polypeptide binding]; other site
318586005217	CoA binding site [chemical binding]; other site
318586005218	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
318586005219	catalytic core [active]
318586005220	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
318586005221	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
318586005222	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
318586005223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586005224	NAD(P) binding site [chemical binding]; other site
318586005225	active site
318586005226	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
318586005227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586005228	S-adenosylmethionine binding site [chemical binding]; other site
318586005229	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
318586005230	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
318586005231	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
318586005232	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586005233	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586005234	putative DNA binding site [nucleotide binding]; other site
318586005235	putative Zn2+ binding site [ion binding]; other site
318586005236	AsnC family; Region: AsnC_trans_reg; pfam01037
318586005237	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586005238	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586005239	putative DNA binding site [nucleotide binding]; other site
318586005240	putative Zn2+ binding site [ion binding]; other site
318586005241	AsnC family; Region: AsnC_trans_reg; pfam01037
318586005242	ketol-acid reductoisomerase; Provisional; Region: PRK05479
318586005243	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
318586005244	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
318586005245	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
318586005246	EamA-like transporter family; Region: EamA; cl17759
318586005247	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
318586005248	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
318586005249	putative active site [active]
318586005250	putative PHP Thumb interface [polypeptide binding]; other site
318586005251	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
318586005252	generic binding surface I; other site
318586005253	generic binding surface II; other site
318586005254	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
318586005255	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586005256	Walker A/P-loop; other site
318586005257	ATP binding site [chemical binding]; other site
318586005258	Q-loop/lid; other site
318586005259	ABC transporter signature motif; other site
318586005260	Walker B; other site
318586005261	D-loop; other site
318586005262	H-loop/switch region; other site
318586005263	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586005264	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
318586005265	TM-ABC transporter signature motif; other site
318586005266	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
318586005267	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586005268	TM-ABC transporter signature motif; other site
318586005269	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
318586005270	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
318586005271	putative ligand binding site [chemical binding]; other site
318586005272	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
318586005273	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
318586005274	DPS ferroxidase diiron center [ion binding]; other site
318586005275	dimerization interface [polypeptide binding]; other site
318586005276	ion pore; other site
318586005277	acyl carrier protein; Provisional; Region: acpP; PRK00982
318586005278	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
318586005279	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
318586005280	NAD(P) binding site [chemical binding]; other site
318586005281	homotetramer interface [polypeptide binding]; other site
318586005282	homodimer interface [polypeptide binding]; other site
318586005283	active site
318586005284	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
318586005285	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
318586005286	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586005287	HAMP domain; Region: HAMP; pfam00672
318586005288	dimerization interface [polypeptide binding]; other site
318586005289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586005290	ATP binding site [chemical binding]; other site
318586005291	Mg2+ binding site [ion binding]; other site
318586005292	G-X-G motif; other site
318586005293	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586005294	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
318586005295	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
318586005296	FAD binding pocket [chemical binding]; other site
318586005297	FAD binding motif [chemical binding]; other site
318586005298	phosphate binding motif [ion binding]; other site
318586005299	NAD binding pocket [chemical binding]; other site
318586005300	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
318586005301	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586005302	intersubunit interface [polypeptide binding]; other site
318586005303	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
318586005304	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586005305	N-terminal plug; other site
318586005306	ligand-binding site [chemical binding]; other site
318586005307	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586005308	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
318586005309	transmembrane helices; other site
318586005310	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
318586005311	TrkA-C domain; Region: TrkA_C; pfam02080
318586005312	TrkA-C domain; Region: TrkA_C; pfam02080
318586005313	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
318586005314	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
318586005315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586005316	putative substrate translocation pore; other site
318586005317	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
318586005318	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586005319	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586005320	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586005321	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
318586005322	Protein export membrane protein; Region: SecD_SecF; cl14618
318586005323	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
318586005324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
318586005325	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
318586005326	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586005327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586005328	active site
318586005329	phosphorylation site [posttranslational modification]
318586005330	intermolecular recognition site; other site
318586005331	dimerization interface [polypeptide binding]; other site
318586005332	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586005333	dimerization interface [polypeptide binding]; other site
318586005334	DNA binding residues [nucleotide binding]
318586005335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586005336	sequence-specific DNA binding site [nucleotide binding]; other site
318586005337	salt bridge; other site
318586005338	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
318586005339	Response regulator receiver domain; Region: Response_reg; pfam00072
318586005340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586005341	active site
318586005342	phosphorylation site [posttranslational modification]
318586005343	intermolecular recognition site; other site
318586005344	dimerization interface [polypeptide binding]; other site
318586005345	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
318586005346	Na binding site [ion binding]; other site
318586005347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586005348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586005349	dimer interface [polypeptide binding]; other site
318586005350	phosphorylation site [posttranslational modification]
318586005351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586005352	ATP binding site [chemical binding]; other site
318586005353	Mg2+ binding site [ion binding]; other site
318586005354	G-X-G motif; other site
318586005355	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
318586005356	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
318586005357	rRNA binding site [nucleotide binding]; other site
318586005358	predicted 30S ribosome binding site; other site
318586005359	Maf-like protein; Region: Maf; pfam02545
318586005360	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
318586005361	active site
318586005362	dimer interface [polypeptide binding]; other site
318586005363	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
318586005364	RNA binding site [nucleotide binding]; other site
318586005365	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
318586005366	Domain of unknown function (DUF329); Region: DUF329; pfam03884
318586005367	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
318586005368	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
318586005369	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
318586005370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586005371	Coenzyme A binding pocket [chemical binding]; other site
318586005372	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
318586005373	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
318586005374	Walker A/P-loop; other site
318586005375	ATP binding site [chemical binding]; other site
318586005376	Q-loop/lid; other site
318586005377	ABC transporter signature motif; other site
318586005378	Walker B; other site
318586005379	D-loop; other site
318586005380	H-loop/switch region; other site
318586005381	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586005382	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
318586005383	sulfate transport protein; Provisional; Region: cysT; CHL00187
318586005384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586005385	dimer interface [polypeptide binding]; other site
318586005386	conserved gate region; other site
318586005387	putative PBP binding loops; other site
318586005388	ABC-ATPase subunit interface; other site
318586005389	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
318586005390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586005391	dimer interface [polypeptide binding]; other site
318586005392	conserved gate region; other site
318586005393	putative PBP binding loops; other site
318586005394	ABC-ATPase subunit interface; other site
318586005395	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
318586005396	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
318586005397	putative metal binding site [ion binding]; other site
318586005398	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
318586005399	HSP70 interaction site [polypeptide binding]; other site
318586005400	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586005401	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
318586005402	putative ADP-binding pocket [chemical binding]; other site
318586005403	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
318586005404	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586005405	Walker A/P-loop; other site
318586005406	ATP binding site [chemical binding]; other site
318586005407	Q-loop/lid; other site
318586005408	ABC transporter signature motif; other site
318586005409	Walker B; other site
318586005410	D-loop; other site
318586005411	H-loop/switch region; other site
318586005412	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
318586005413	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586005414	Walker A/P-loop; other site
318586005415	ATP binding site [chemical binding]; other site
318586005416	Q-loop/lid; other site
318586005417	ABC transporter signature motif; other site
318586005418	Walker B; other site
318586005419	D-loop; other site
318586005420	H-loop/switch region; other site
318586005421	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586005422	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
318586005423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586005424	dimer interface [polypeptide binding]; other site
318586005425	conserved gate region; other site
318586005426	putative PBP binding loops; other site
318586005427	ABC-ATPase subunit interface; other site
318586005428	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
318586005429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586005430	dimer interface [polypeptide binding]; other site
318586005431	conserved gate region; other site
318586005432	putative PBP binding loops; other site
318586005433	ABC-ATPase subunit interface; other site
318586005434	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
318586005435	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
318586005436	Cytochrome c2 [Energy production and conversion]; Region: COG3474
318586005437	prephenate dehydratase; Provisional; Region: PRK11899
318586005438	Prephenate dehydratase; Region: PDT; pfam00800
318586005439	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
318586005440	putative L-Phe binding site [chemical binding]; other site
318586005441	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
318586005442	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
318586005443	active site
318586005444	metal binding site [ion binding]; metal-binding site
318586005445	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
318586005446	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586005447	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
318586005448	substrate binding site [chemical binding]; other site
318586005449	ATP binding site [chemical binding]; other site
318586005450	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
318586005451	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
318586005452	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
318586005453	active site
318586005454	nucleophile elbow; other site
318586005455	peptide chain release factor 2; Validated; Region: prfB; PRK00578
318586005456	This domain is found in peptide chain release factors; Region: PCRF; smart00937
318586005457	RF-1 domain; Region: RF-1; pfam00472
318586005458	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
318586005459	Transglycosylase; Region: Transgly; pfam00912
318586005460	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
318586005461	AMIN domain; Region: AMIN; pfam11741
318586005462	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
318586005463	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
318586005464	active site
318586005465	metal binding site [ion binding]; metal-binding site
318586005466	aspartate aminotransferase; Provisional; Region: PRK05764
318586005467	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586005468	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586005469	homodimer interface [polypeptide binding]; other site
318586005470	catalytic residue [active]
318586005471	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
318586005472	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
318586005473	catalytic residues [active]
318586005474	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
318586005475	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
318586005476	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
318586005477	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
318586005478	Helix-turn-helix domain; Region: HTH_25; pfam13413
318586005479	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
318586005480	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
318586005481	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
318586005482	substrate-cofactor binding pocket; other site
318586005483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586005484	catalytic residue [active]
318586005485	hypothetical protein; Validated; Region: PRK09104
318586005486	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
318586005487	metal binding site [ion binding]; metal-binding site
318586005488	putative dimer interface [polypeptide binding]; other site
318586005489	LysE type translocator; Region: LysE; cl00565
318586005490	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
318586005491	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
318586005492	4Fe-4S binding domain; Region: Fer4; pfam00037
318586005493	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
318586005494	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
318586005495	RNA binding surface [nucleotide binding]; other site
318586005496	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
318586005497	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586005498	nucleotide binding region [chemical binding]; other site
318586005499	ATP-binding site [chemical binding]; other site
318586005500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586005501	binding surface
318586005502	TPR repeat; Region: TPR_11; pfam13414
318586005503	TPR motif; other site
318586005504	TPR repeat; Region: TPR_11; pfam13414
318586005505	SCP-2 sterol transfer family; Region: SCP2; pfam02036
318586005506	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
318586005507	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
318586005508	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
318586005509	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
318586005510	active site
318586005511	Zn binding site [ion binding]; other site
318586005512	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
318586005513	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586005514	active site
318586005515	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586005516	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
318586005517	putative C-terminal domain interface [polypeptide binding]; other site
318586005518	putative GSH binding site (G-site) [chemical binding]; other site
318586005519	putative dimer interface [polypeptide binding]; other site
318586005520	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
318586005521	dimer interface [polypeptide binding]; other site
318586005522	N-terminal domain interface [polypeptide binding]; other site
318586005523	putative substrate binding pocket (H-site) [chemical binding]; other site
318586005524	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
318586005525	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
318586005526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586005527	ATP binding site [chemical binding]; other site
318586005528	Mg2+ binding site [ion binding]; other site
318586005529	G-X-G motif; other site
318586005530	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
318586005531	anchoring element; other site
318586005532	dimer interface [polypeptide binding]; other site
318586005533	ATP binding site [chemical binding]; other site
318586005534	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
318586005535	active site
318586005536	metal binding site [ion binding]; metal-binding site
318586005537	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
318586005538	Uncharacterized conserved protein [Function unknown]; Region: COG1742
318586005539	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
318586005540	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
318586005541	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
318586005542	Walker A/P-loop; other site
318586005543	ATP binding site [chemical binding]; other site
318586005544	Q-loop/lid; other site
318586005545	ABC transporter signature motif; other site
318586005546	Walker B; other site
318586005547	D-loop; other site
318586005548	H-loop/switch region; other site
318586005549	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
318586005550	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
318586005551	FtsX-like permease family; Region: FtsX; pfam02687
318586005552	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
318586005553	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
318586005554	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
318586005555	metal-binding site [ion binding]
318586005556	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586005557	Soluble P-type ATPase [General function prediction only]; Region: COG4087
318586005558	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
318586005559	FixH; Region: FixH; pfam05751
318586005560	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
318586005561	4Fe-4S binding domain; Region: Fer4_5; pfam12801
318586005562	4Fe-4S binding domain; Region: Fer4; cl02805
318586005563	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
318586005564	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
318586005565	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
318586005566	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
318586005567	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
318586005568	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
318586005569	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
318586005570	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
318586005571	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
318586005572	Low-spin heme binding site [chemical binding]; other site
318586005573	Putative water exit pathway; other site
318586005574	Binuclear center (active site) [active]
318586005575	Putative proton exit pathway; other site
318586005576	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
318586005577	Ligand Binding Site [chemical binding]; other site
318586005578	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
318586005579	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
318586005580	ligand binding site [chemical binding]; other site
318586005581	flexible hinge region; other site
318586005582	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
318586005583	putative switch regulator; other site
318586005584	non-specific DNA interactions [nucleotide binding]; other site
318586005585	DNA binding site [nucleotide binding]
318586005586	sequence specific DNA binding site [nucleotide binding]; other site
318586005587	putative cAMP binding site [chemical binding]; other site
318586005588	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
318586005589	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586005590	FeS/SAM binding site; other site
318586005591	HemN C-terminal domain; Region: HemN_C; pfam06969
318586005592	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
318586005593	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
318586005594	DNA polymerase I; Provisional; Region: PRK05755
318586005595	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
318586005596	active site
318586005597	metal binding site 1 [ion binding]; metal-binding site
318586005598	putative 5' ssDNA interaction site; other site
318586005599	metal binding site 3; metal-binding site
318586005600	metal binding site 2 [ion binding]; metal-binding site
318586005601	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
318586005602	putative DNA binding site [nucleotide binding]; other site
318586005603	putative metal binding site [ion binding]; other site
318586005604	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
318586005605	active site
318586005606	catalytic site [active]
318586005607	substrate binding site [chemical binding]; other site
318586005608	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
318586005609	active site
318586005610	DNA binding site [nucleotide binding]
318586005611	catalytic site [active]
318586005612	Zinc-finger domain; Region: zf-CHCC; pfam10276
318586005613	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
318586005614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586005615	Walker A/P-loop; other site
318586005616	ATP binding site [chemical binding]; other site
318586005617	Q-loop/lid; other site
318586005618	ABC transporter signature motif; other site
318586005619	Walker B; other site
318586005620	D-loop; other site
318586005621	H-loop/switch region; other site
318586005622	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
318586005623	nucleotide binding site/active site [active]
318586005624	HIT family signature motif; other site
318586005625	catalytic residue [active]
318586005626	Core-2/I-Branching enzyme; Region: Branch; pfam02485
318586005627	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
318586005628	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
318586005629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
318586005630	putative phosphate acyltransferase; Provisional; Region: PRK05331
318586005631	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
318586005632	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
318586005633	dimer interface [polypeptide binding]; other site
318586005634	active site
318586005635	CoA binding pocket [chemical binding]; other site
318586005636	hypothetical protein; Provisional; Region: PRK11019
318586005637	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
318586005638	IHF dimer interface [polypeptide binding]; other site
318586005639	IHF - DNA interface [nucleotide binding]; other site
318586005640	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
318586005641	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
318586005642	DNA binding residues [nucleotide binding]
318586005643	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
318586005644	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
318586005645	trimer interface [polypeptide binding]; other site
318586005646	active site
318586005647	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
318586005648	trimer interface [polypeptide binding]; other site
318586005649	active site
318586005650	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
318586005651	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
318586005652	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
318586005653	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
318586005654	Sporulation related domain; Region: SPOR; pfam05036
318586005655	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
318586005656	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
318586005657	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
318586005658	active site
318586005659	HIGH motif; other site
318586005660	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586005661	KMSK motif region; other site
318586005662	tRNA binding surface [nucleotide binding]; other site
318586005663	DALR anticodon binding domain; Region: DALR_1; smart00836
318586005664	anticodon binding site; other site
318586005665	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
318586005666	S-adenosylmethionine synthetase; Validated; Region: PRK05250
318586005667	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
318586005668	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
318586005669	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
318586005670	HSP70 interaction site [polypeptide binding]; other site
318586005671	BolA-like protein; Region: BolA; pfam01722
318586005672	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
318586005673	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
318586005674	putative active site [active]
318586005675	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
318586005676	DHH family; Region: DHH; pfam01368
318586005677	DHHA1 domain; Region: DHHA1; pfam02272
318586005678	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
318586005679	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586005680	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586005681	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
318586005682	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586005683	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586005684	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
318586005685	IMP binding site; other site
318586005686	dimer interface [polypeptide binding]; other site
318586005687	partial ornithine binding site; other site
318586005688	hypothetical protein; Provisional; Region: PRK05208
318586005689	Cell division protein ZapA; Region: ZapA; pfam05164
318586005690	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
318586005691	putative active site pocket [active]
318586005692	4-fold oligomerization interface [polypeptide binding]; other site
318586005693	metal binding residues [ion binding]; metal-binding site
318586005694	3-fold/trimer interface [polypeptide binding]; other site
318586005695	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
318586005696	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
318586005697	putative active site [active]
318586005698	oxyanion strand; other site
318586005699	catalytic triad [active]
318586005700	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
318586005701	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
318586005702	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
318586005703	catalytic residues [active]
318586005704	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
318586005705	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
318586005706	substrate binding site [chemical binding]; other site
318586005707	glutamase interaction surface [polypeptide binding]; other site
318586005708	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
318586005709	metal binding site [ion binding]; metal-binding site
318586005710	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
318586005711	MgtC family; Region: MgtC; pfam02308
318586005712	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
318586005713	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
318586005714	catalytic site [active]
318586005715	putative active site [active]
318586005716	putative substrate binding site [chemical binding]; other site
318586005717	HRDC domain; Region: HRDC; pfam00570
318586005718	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
318586005719	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
318586005720	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
318586005721	methionine sulfoxide reductase B; Provisional; Region: PRK00222
318586005722	SelR domain; Region: SelR; pfam01641
318586005723	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
318586005724	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
318586005725	choline dehydrogenase; Validated; Region: PRK02106
318586005726	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
318586005727	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586005728	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
318586005729	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586005730	NAD(P) binding site [chemical binding]; other site
318586005731	catalytic residues [active]
318586005732	transcriptional regulator BetI; Validated; Region: PRK00767
318586005733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586005734	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
318586005735	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
318586005736	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
318586005737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586005738	dimer interface [polypeptide binding]; other site
318586005739	conserved gate region; other site
318586005740	putative PBP binding loops; other site
318586005741	ABC-ATPase subunit interface; other site
318586005742	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586005743	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
318586005744	Walker A/P-loop; other site
318586005745	ATP binding site [chemical binding]; other site
318586005746	Q-loop/lid; other site
318586005747	ABC transporter signature motif; other site
318586005748	Walker B; other site
318586005749	D-loop; other site
318586005750	H-loop/switch region; other site
318586005751	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586005752	EamA-like transporter family; Region: EamA; pfam00892
318586005753	EamA-like transporter family; Region: EamA; pfam00892
318586005754	Lysine efflux permease [General function prediction only]; Region: COG1279
318586005755	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
318586005756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586005757	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586005758	dimerization interface [polypeptide binding]; other site
318586005759	hypothetical protein; Validated; Region: PRK00110
318586005760	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
318586005761	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
318586005762	fumarate hydratase; Reviewed; Region: fumC; PRK00485
318586005763	Class II fumarases; Region: Fumarase_classII; cd01362
318586005764	active site
318586005765	tetramer interface [polypeptide binding]; other site
318586005766	Stringent starvation protein B; Region: SspB; pfam04386
318586005767	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
318586005768	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
318586005769	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
318586005770	active site
318586005771	HIGH motif; other site
318586005772	dimer interface [polypeptide binding]; other site
318586005773	KMSKS motif; other site
318586005774	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
318586005775	RNA binding surface [nucleotide binding]; other site
318586005776	hypothetical protein; Provisional; Region: PRK00944
318586005777	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
318586005778	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
318586005779	active site
318586005780	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
318586005781	active site
318586005782	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
318586005783	Phosphoglycerate kinase; Region: PGK; pfam00162
318586005784	substrate binding site [chemical binding]; other site
318586005785	hinge regions; other site
318586005786	ADP binding site [chemical binding]; other site
318586005787	catalytic site [active]
318586005788	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
318586005789	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
318586005790	putative active site; other site
318586005791	catalytic residue [active]
318586005792	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
318586005793	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
318586005794	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
318586005795	P loop; other site
318586005796	GTP binding site [chemical binding]; other site
318586005797	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
318586005798	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
318586005799	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
318586005800	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
318586005801	motif 1; other site
318586005802	dimer interface [polypeptide binding]; other site
318586005803	active site
318586005804	motif 2; other site
318586005805	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
318586005806	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
318586005807	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
318586005808	dimer interface [polypeptide binding]; other site
318586005809	motif 1; other site
318586005810	motif 2; other site
318586005811	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
318586005812	active site
318586005813	motif 3; other site
318586005814	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
318586005815	anticodon binding site; other site
318586005816	SlyX; Region: SlyX; pfam04102
318586005817	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
318586005818	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
318586005819	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
318586005820	GatB domain; Region: GatB_Yqey; smart00845
318586005821	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
318586005822	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
318586005823	Uncharacterized conserved protein [Function unknown]; Region: COG2968
318586005824	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
318586005825	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
318586005826	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
318586005827	homodimer interface [polypeptide binding]; other site
318586005828	substrate-cofactor binding pocket; other site
318586005829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586005830	catalytic residue [active]
318586005831	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
318586005832	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
318586005833	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
318586005834	substrate binding pocket [chemical binding]; other site
318586005835	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
318586005836	B12 binding site [chemical binding]; other site
318586005837	cobalt ligand [ion binding]; other site
318586005838	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
318586005839	lipoate-protein ligase B; Provisional; Region: PRK14341
318586005840	Cytochrome c; Region: Cytochrom_C; cl11414
318586005841	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
318586005842	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
318586005843	Subunit I/III interface [polypeptide binding]; other site
318586005844	D-pathway; other site
318586005845	Subunit I/VIIc interface [polypeptide binding]; other site
318586005846	Subunit I/IV interface [polypeptide binding]; other site
318586005847	Subunit I/II interface [polypeptide binding]; other site
318586005848	Low-spin heme (heme a) binding site [chemical binding]; other site
318586005849	Subunit I/VIIa interface [polypeptide binding]; other site
318586005850	Subunit I/VIa interface [polypeptide binding]; other site
318586005851	Dimer interface; other site
318586005852	Putative water exit pathway; other site
318586005853	Binuclear center (heme a3/CuB) [ion binding]; other site
318586005854	K-pathway; other site
318586005855	Subunit I/Vb interface [polypeptide binding]; other site
318586005856	Putative proton exit pathway; other site
318586005857	Subunit I/VIb interface; other site
318586005858	Subunit I/VIc interface [polypeptide binding]; other site
318586005859	Electron transfer pathway; other site
318586005860	Subunit I/VIIIb interface [polypeptide binding]; other site
318586005861	Subunit I/VIIb interface [polypeptide binding]; other site
318586005862	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
318586005863	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586005864	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586005865	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
318586005866	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
318586005867	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
318586005868	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
318586005869	dimerization interface [polypeptide binding]; other site
318586005870	ligand binding site [chemical binding]; other site
318586005871	NADP binding site [chemical binding]; other site
318586005872	catalytic site [active]
318586005873	Bacterial SH3 domain; Region: SH3_4; pfam06347
318586005874	Bacterial SH3 domain; Region: SH3_4; pfam06347
318586005875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
318586005876	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
318586005877	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
318586005878	active site
318586005879	Zn binding site [ion binding]; other site
318586005880	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
318586005881	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
318586005882	ATP binding site [chemical binding]; other site
318586005883	substrate interface [chemical binding]; other site
318586005884	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
318586005885	trimer interface [polypeptide binding]; other site
318586005886	active site
318586005887	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
318586005888	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
318586005889	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
318586005890	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
318586005891	active site
318586005892	dimer interface [polypeptide binding]; other site
318586005893	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
318586005894	dimer interface [polypeptide binding]; other site
318586005895	active site
318586005896	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
318586005897	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
318586005898	putative active site [active]
318586005899	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
318586005900	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
318586005901	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
318586005902	PIN domain; Region: PIN_3; pfam13470
318586005903	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
318586005904	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
318586005905	putative RNA binding site [nucleotide binding]; other site
318586005906	Methyltransferase domain; Region: Methyltransf_26; pfam13659
318586005907	phosphogluconate dehydratase; Validated; Region: PRK09054
318586005908	6-phosphogluconate dehydratase; Region: edd; TIGR01196
318586005909	PAS fold; Region: PAS_4; pfam08448
318586005910	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
318586005911	putative active site [active]
318586005912	heme pocket [chemical binding]; other site
318586005913	Low molecular weight phosphatase family; Region: LMWPc; cd00115
318586005914	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
318586005915	active site
318586005916	hypothetical protein; Provisional; Region: PRK02853
318586005917	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
318586005918	histidinol dehydrogenase; Region: hisD; TIGR00069
318586005919	NAD binding site [chemical binding]; other site
318586005920	dimerization interface [polypeptide binding]; other site
318586005921	product binding site; other site
318586005922	substrate binding site [chemical binding]; other site
318586005923	zinc binding site [ion binding]; other site
318586005924	catalytic residues [active]
318586005925	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
318586005926	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
318586005927	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
318586005928	hinge; other site
318586005929	active site
318586005930	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
318586005931	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586005932	sequence-specific DNA binding site [nucleotide binding]; other site
318586005933	salt bridge; other site
318586005934	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
318586005935	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
318586005936	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
318586005937	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
318586005938	metal binding triad [ion binding]; metal-binding site
318586005939	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586005940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586005941	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586005942	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
318586005943	catalytic residues [active]
318586005944	catalytic nucleophile [active]
318586005945	Recombinase; Region: Recombinase; pfam07508
318586005946	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
318586005947	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
318586005948	Protein of unknown function (DUF1320); Region: DUF1320; cl01818
318586005949	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586005950	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586005951	DNA binding site [nucleotide binding]
318586005952	domain linker motif; other site
318586005953	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
318586005954	putative dimerization interface [polypeptide binding]; other site
318586005955	putative ligand binding site [chemical binding]; other site
318586005956	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
318586005957	active site
318586005958	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
318586005959	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
318586005960	putative MPT binding site; other site
318586005961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586005962	Coenzyme A binding pocket [chemical binding]; other site
318586005963	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
318586005964	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
318586005965	aromatic arch; other site
318586005966	DCoH dimer interaction site [polypeptide binding]; other site
318586005967	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
318586005968	DCoH tetramer interaction site [polypeptide binding]; other site
318586005969	substrate binding site [chemical binding]; other site
318586005970	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
318586005971	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
318586005972	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
318586005973	putative active site [active]
318586005974	catalytic site [active]
318586005975	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
318586005976	putative active site [active]
318586005977	catalytic site [active]
318586005978	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
318586005979	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
318586005980	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
318586005981	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
318586005982	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
318586005983	Predicted ATPase [General function prediction only]; Region: COG1485
318586005984	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
318586005985	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586005986	NAD(P) binding site [chemical binding]; other site
318586005987	catalytic residues [active]
318586005988	benzoate transport; Region: 2A0115; TIGR00895
318586005989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586005990	putative substrate translocation pore; other site
318586005991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586005992	HemY protein N-terminus; Region: HemY_N; pfam07219
318586005993	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
318586005994	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
318586005995	active site
318586005996	UGMP family protein; Validated; Region: PRK09604
318586005997	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
318586005998	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
318586005999	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
318586006000	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
318586006001	YciI-like protein; Reviewed; Region: PRK12863
318586006002	EVE domain; Region: EVE; cl00728
318586006003	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
318586006004	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586006005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586006006	Walker A/P-loop; other site
318586006007	ATP binding site [chemical binding]; other site
318586006008	Q-loop/lid; other site
318586006009	ABC transporter signature motif; other site
318586006010	Walker B; other site
318586006011	D-loop; other site
318586006012	H-loop/switch region; other site
318586006013	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
318586006014	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
318586006015	BON domain; Region: BON; pfam04972
318586006016	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
318586006017	AMP-binding domain protein; Validated; Region: PRK07529
318586006018	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586006019	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
318586006020	acyl-activating enzyme (AAE) consensus motif; other site
318586006021	putative AMP binding site [chemical binding]; other site
318586006022	putative active site [active]
318586006023	putative CoA binding site [chemical binding]; other site
318586006024	Protein of unknown function (DUF563); Region: DUF563; pfam04577
318586006025	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
318586006026	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
318586006027	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586006028	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586006029	ABC transporter; Region: ABC_tran_2; pfam12848
318586006030	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586006031	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
318586006032	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
318586006033	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
318586006034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586006035	FeS/SAM binding site; other site
318586006036	ABC-2 type transporter; Region: ABC2_membrane; cl17235
318586006037	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
318586006038	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
318586006039	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
318586006040	Walker A/P-loop; other site
318586006041	ATP binding site [chemical binding]; other site
318586006042	Q-loop/lid; other site
318586006043	ABC transporter signature motif; other site
318586006044	Walker B; other site
318586006045	D-loop; other site
318586006046	H-loop/switch region; other site
318586006047	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
318586006048	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
318586006049	putative acyl-acceptor binding pocket; other site
318586006050	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
318586006051	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
318586006052	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
318586006053	Walker A/P-loop; other site
318586006054	ATP binding site [chemical binding]; other site
318586006055	Q-loop/lid; other site
318586006056	ABC transporter signature motif; other site
318586006057	Walker B; other site
318586006058	D-loop; other site
318586006059	H-loop/switch region; other site
318586006060	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
318586006061	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
318586006062	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
318586006063	diaminopimelate decarboxylase; Region: lysA; TIGR01048
318586006064	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
318586006065	active site
318586006066	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586006067	substrate binding site [chemical binding]; other site
318586006068	catalytic residues [active]
318586006069	dimer interface [polypeptide binding]; other site
318586006070	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
318586006071	argininosuccinate lyase; Provisional; Region: PRK00855
318586006072	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
318586006073	active sites [active]
318586006074	tetramer interface [polypeptide binding]; other site
318586006075	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
318586006076	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
318586006077	catalytic residues [active]
318586006078	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
318586006079	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
318586006080	putative acyltransferase; Provisional; Region: PRK05790
318586006081	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586006082	dimer interface [polypeptide binding]; other site
318586006083	active site
318586006084	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
318586006085	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
318586006086	NAD(P) binding site [chemical binding]; other site
318586006087	homotetramer interface [polypeptide binding]; other site
318586006088	homodimer interface [polypeptide binding]; other site
318586006089	active site
318586006090	Protein of unknown function (DUF465); Region: DUF465; pfam04325
318586006091	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
318586006092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586006093	S-adenosylmethionine binding site [chemical binding]; other site
318586006094	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
318586006095	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
318586006096	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
318586006097	substrate binding pocket [chemical binding]; other site
318586006098	chain length determination region; other site
318586006099	substrate-Mg2+ binding site; other site
318586006100	catalytic residues [active]
318586006101	aspartate-rich region 1; other site
318586006102	active site lid residues [active]
318586006103	aspartate-rich region 2; other site
318586006104	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
318586006105	Transglycosylase; Region: Transgly; pfam00912
318586006106	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
318586006107	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
318586006108	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
318586006109	VacJ like lipoprotein; Region: VacJ; cl01073
318586006110	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
318586006111	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
318586006112	Walker A/P-loop; other site
318586006113	ATP binding site [chemical binding]; other site
318586006114	Q-loop/lid; other site
318586006115	ABC transporter signature motif; other site
318586006116	Walker B; other site
318586006117	D-loop; other site
318586006118	H-loop/switch region; other site
318586006119	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
318586006120	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586006121	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586006122	ornithine carbamoyltransferase; Provisional; Region: PRK00779
318586006123	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
318586006124	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
318586006125	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
318586006126	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
318586006127	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586006128	inhibitor-cofactor binding pocket; inhibition site
318586006129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586006130	catalytic residue [active]
318586006131	ABC-2 type transporter; Region: ABC2_membrane; cl17235
318586006132	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
318586006133	GcrA cell cycle regulator; Region: GcrA; cl11564
318586006134	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
318586006135	nudix motif; other site
318586006136	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
318586006137	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
318586006138	active site
318586006139	HIGH motif; other site
318586006140	KMSKS motif; other site
318586006141	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
318586006142	tRNA binding surface [nucleotide binding]; other site
318586006143	anticodon binding site; other site
318586006144	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
318586006145	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586006146	N-terminal plug; other site
318586006147	ligand-binding site [chemical binding]; other site
318586006148	agmatinase; Region: agmatinase; TIGR01230
318586006149	Arginase family; Region: Arginase; cd09989
318586006150	active site
318586006151	Mn binding site [ion binding]; other site
318586006152	oligomer interface [polypeptide binding]; other site
318586006153	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
318586006154	DNA binding residues [nucleotide binding]
318586006155	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
318586006156	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
318586006157	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586006158	active site
318586006159	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586006160	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
318586006161	cofactor binding site; other site
318586006162	DNA binding site [nucleotide binding]
318586006163	substrate interaction site [chemical binding]; other site
318586006164	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586006165	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
318586006166	additional DNA contacts [nucleotide binding]; other site
318586006167	mismatch recognition site; other site
318586006168	active site
318586006169	zinc binding site [ion binding]; other site
318586006170	DNA intercalation site [nucleotide binding]; other site
318586006171	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
318586006172	Phage terminase, small subunit; Region: Terminase_4; pfam05119
318586006173	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586006174	DNA-binding site [nucleotide binding]; DNA binding site
318586006175	RNA-binding motif; other site
318586006176	Protein of unknown function (DUF982); Region: DUF982; pfam06169
318586006177	ParB-like nuclease domain; Region: ParB; smart00470
318586006178	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
318586006179	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
318586006180	DNA methylase; Region: N6_N4_Mtase; cl17433
318586006181	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
318586006182	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586006183	active site
318586006184	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
318586006185	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
318586006186	oligomeric interface; other site
318586006187	putative active site [active]
318586006188	homodimer interface [polypeptide binding]; other site
318586006189	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
318586006190	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586006191	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
318586006192	catalytic residues [active]
318586006193	catalytic nucleophile [active]
318586006194	Presynaptic Site I dimer interface [polypeptide binding]; other site
318586006195	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
318586006196	Synaptic Flat tetramer interface [polypeptide binding]; other site
318586006197	Synaptic Site I dimer interface [polypeptide binding]; other site
318586006198	DNA binding site [nucleotide binding]
318586006199	Recombinase; Region: Recombinase; pfam07508
318586006200	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
318586006201	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
318586006202	WYL domain; Region: WYL; pfam13280
318586006203	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
318586006204	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
318586006205	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
318586006206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586006207	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586006208	DNA binding residues [nucleotide binding]
318586006209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586006210	ATP binding site [chemical binding]; other site
318586006211	Mg2+ binding site [ion binding]; other site
318586006212	G-X-G motif; other site
318586006213	Z1 domain; Region: Z1; pfam10593
318586006214	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
318586006215	AIPR protein; Region: AIPR; pfam10592
318586006216	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586006217	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
318586006218	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586006219	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
318586006220	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
318586006221	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
318586006222	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
318586006223	Thioredoxin; Region: Thioredoxin_4; pfam13462
318586006224	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
318586006225	Protein of unknown function (DUF721); Region: DUF721; pfam05258
318586006226	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
318586006227	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
318586006228	minor groove reading motif; other site
318586006229	helix-hairpin-helix signature motif; other site
318586006230	substrate binding pocket [chemical binding]; other site
318586006231	active site
318586006232	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
318586006233	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
318586006234	DNA binding and oxoG recognition site [nucleotide binding]
318586006235	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
318586006236	Fatty acid desaturase; Region: FA_desaturase; pfam00487
318586006237	Di-iron ligands [ion binding]; other site
318586006238	GSCFA family; Region: GSCFA; pfam08885
318586006239	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
318586006240	DNA methylase; Region: N6_N4_Mtase; pfam01555
318586006241	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
318586006242	RNA/DNA hybrid binding site [nucleotide binding]; other site
318586006243	active site
318586006244	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
318586006245	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
318586006246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586006247	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586006248	putative substrate translocation pore; other site
318586006249	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586006250	DNA-binding site [nucleotide binding]; DNA binding site
318586006251	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
318586006252	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
318586006253	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586006254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
318586006255	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586006256	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
318586006257	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
318586006258	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
318586006259	ligand binding site [chemical binding]; other site
318586006260	flexible hinge region; other site
318586006261	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
318586006262	non-specific DNA interactions [nucleotide binding]; other site
318586006263	DNA binding site [nucleotide binding]
318586006264	sequence specific DNA binding site [nucleotide binding]; other site
318586006265	putative cAMP binding site [chemical binding]; other site
318586006266	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
318586006267	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
318586006268	Walker A motif; other site
318586006269	ATP binding site [chemical binding]; other site
318586006270	Walker B motif; other site
318586006271	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627
318586006272	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632
318586006273	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
318586006274	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
318586006275	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
318586006276	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
318586006277	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690
318586006278	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
318586006279	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
318586006280	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
318586006281	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
318586006282	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
318586006283	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
318586006284	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
318586006285	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
318586006286	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
318586006287	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
318586006288	substrate binding site; other site
318586006289	tetramer interface; other site
318586006290	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
318586006291	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
318586006292	NADP binding site [chemical binding]; other site
318586006293	active site
318586006294	putative substrate binding site [chemical binding]; other site
318586006295	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
318586006296	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
318586006297	NAD binding site [chemical binding]; other site
318586006298	substrate binding site [chemical binding]; other site
318586006299	homodimer interface [polypeptide binding]; other site
318586006300	active site
318586006301	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
318586006302	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
318586006303	ABC-2 type transporter; Region: ABC2_membrane; cl17235
318586006304	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
318586006305	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
318586006306	Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177
318586006307	Walker A/P-loop; other site
318586006308	ATP binding site [chemical binding]; other site
318586006309	Q-loop/lid; other site
318586006310	ABC transporter signature motif; other site
318586006311	Walker B; other site
318586006312	D-loop; other site
318586006313	H-loop/switch region; other site
318586006314	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
318586006315	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
318586006316	Predicted amidohydrolase [General function prediction only]; Region: COG0388
318586006317	putative active site [active]
318586006318	catalytic triad [active]
318586006319	putative dimer interface [polypeptide binding]; other site
318586006320	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
318586006321	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586006322	Coenzyme A binding pocket [chemical binding]; other site
318586006323	anthranilate synthase component I; Provisional; Region: PRK13573
318586006324	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
318586006325	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
318586006326	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
318586006327	hypothetical protein; Provisional; Region: PRK07550
318586006328	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586006329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586006330	homodimer interface [polypeptide binding]; other site
318586006331	catalytic residue [active]
318586006332	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
318586006333	Glutamine amidotransferase class-I; Region: GATase; pfam00117
318586006334	glutamine binding [chemical binding]; other site
318586006335	catalytic triad [active]
318586006336	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
318586006337	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
318586006338	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
318586006339	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
318586006340	ligand binding site [chemical binding]; other site
318586006341	active site
318586006342	UGI interface [polypeptide binding]; other site
318586006343	catalytic site [active]
318586006344	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
318586006345	active site
318586006346	ribulose/triose binding site [chemical binding]; other site
318586006347	phosphate binding site [ion binding]; other site
318586006348	substrate (anthranilate) binding pocket [chemical binding]; other site
318586006349	product (indole) binding pocket [chemical binding]; other site
318586006350	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
318586006351	trimer interface [polypeptide binding]; other site
318586006352	dimer interface [polypeptide binding]; other site
318586006353	putative active site [active]
318586006354	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
318586006355	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
318586006356	dimer interface [polypeptide binding]; other site
318586006357	putative functional site; other site
318586006358	putative MPT binding site; other site
318586006359	LexA repressor; Validated; Region: PRK00215
318586006360	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
318586006361	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
318586006362	Catalytic site [active]
318586006363	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
318586006364	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
318586006365	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
318586006366	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
318586006367	thymidylate kinase; Validated; Region: tmk; PRK00698
318586006368	TMP-binding site; other site
318586006369	ATP-binding site [chemical binding]; other site
318586006370	DNA polymerase III subunit delta'; Validated; Region: PRK07471
318586006371	DNA polymerase III subunit delta'; Validated; Region: PRK08485
318586006372	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
318586006373	active site
318586006374	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
318586006375	putative hydrolase; Provisional; Region: PRK02113
318586006376	Predicted permeases [General function prediction only]; Region: COG0679
318586006377	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586006378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586006379	dimer interface [polypeptide binding]; other site
318586006380	conserved gate region; other site
318586006381	putative PBP binding loops; other site
318586006382	ABC-ATPase subunit interface; other site
318586006383	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586006384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586006385	dimer interface [polypeptide binding]; other site
318586006386	conserved gate region; other site
318586006387	putative PBP binding loops; other site
318586006388	ABC-ATPase subunit interface; other site
318586006389	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586006390	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586006391	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586006392	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586006393	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586006394	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
318586006395	Walker A/P-loop; other site
318586006396	ATP binding site [chemical binding]; other site
318586006397	Q-loop/lid; other site
318586006398	ABC transporter signature motif; other site
318586006399	Walker B; other site
318586006400	D-loop; other site
318586006401	H-loop/switch region; other site
318586006402	TOBE domain; Region: TOBE_2; pfam08402
318586006403	Predicted membrane protein [Function unknown]; Region: COG2323
318586006404	short chain dehydrogenase; Provisional; Region: PRK07060
318586006405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586006406	NAD(P) binding site [chemical binding]; other site
318586006407	active site
318586006408	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
318586006409	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
318586006410	N- and C-terminal domain interface [polypeptide binding]; other site
318586006411	active site
318586006412	MgATP binding site [chemical binding]; other site
318586006413	catalytic site [active]
318586006414	metal binding site [ion binding]; metal-binding site
318586006415	carbohydrate binding site [chemical binding]; other site
318586006416	putative homodimer interface [polypeptide binding]; other site
318586006417	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
318586006418	classical (c) SDRs; Region: SDR_c; cd05233
318586006419	NAD(P) binding site [chemical binding]; other site
318586006420	active site
318586006421	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586006422	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586006423	TM-ABC transporter signature motif; other site
318586006424	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
318586006425	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586006426	Walker A/P-loop; other site
318586006427	ATP binding site [chemical binding]; other site
318586006428	Q-loop/lid; other site
318586006429	ABC transporter signature motif; other site
318586006430	Walker B; other site
318586006431	D-loop; other site
318586006432	H-loop/switch region; other site
318586006433	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586006434	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
318586006435	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
318586006436	putative ligand binding site [chemical binding]; other site
318586006437	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
318586006438	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586006439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586006440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586006441	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
318586006442	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
318586006443	N- and C-terminal domain interface [polypeptide binding]; other site
318586006444	active site
318586006445	MgATP binding site [chemical binding]; other site
318586006446	catalytic site [active]
318586006447	metal binding site [ion binding]; metal-binding site
318586006448	xylulose binding site [chemical binding]; other site
318586006449	homodimer interface [polypeptide binding]; other site
318586006450	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
318586006451	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
318586006452	inhibitor binding site; inhibition site
318586006453	catalytic Zn binding site [ion binding]; other site
318586006454	structural Zn binding site [ion binding]; other site
318586006455	NADP binding site [chemical binding]; other site
318586006456	tetramer interface [polypeptide binding]; other site
318586006457	Yqey-like protein; Region: YqeY; pfam09424
318586006458	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
318586006459	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
318586006460	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
318586006461	catalytic site [active]
318586006462	subunit interface [polypeptide binding]; other site
318586006463	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
318586006464	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
318586006465	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
318586006466	DXD motif; other site
318586006467	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
318586006468	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
318586006469	metal binding triad; other site
318586006470	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
318586006471	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
318586006472	metal binding triad; other site
318586006473	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
318586006474	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
318586006475	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
318586006476	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
318586006477	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
318586006478	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586006479	PYR/PP interface [polypeptide binding]; other site
318586006480	dimer interface [polypeptide binding]; other site
318586006481	TPP binding site [chemical binding]; other site
318586006482	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586006483	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
318586006484	TPP-binding site [chemical binding]; other site
318586006485	dimer interface [polypeptide binding]; other site
318586006486	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
318586006487	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
318586006488	putative valine binding site [chemical binding]; other site
318586006489	dimer interface [polypeptide binding]; other site
318586006490	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
318586006491	Peptidase family M48; Region: Peptidase_M48; cl12018
318586006492	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
318586006493	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
318586006494	putative FMN binding site [chemical binding]; other site
318586006495	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
318586006496	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
318586006497	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586006498	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
318586006499	dimer interface [polypeptide binding]; other site
318586006500	substrate binding site [chemical binding]; other site
318586006501	metal binding site [ion binding]; metal-binding site
318586006502	Response regulator receiver domain; Region: Response_reg; pfam00072
318586006503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586006504	active site
318586006505	phosphorylation site [posttranslational modification]
318586006506	intermolecular recognition site; other site
318586006507	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
318586006508	dimerization interface [polypeptide binding]; other site
318586006509	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
318586006510	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
318586006511	Coenzyme A binding pocket [chemical binding]; other site
318586006512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
318586006513	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
318586006514	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
318586006515	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
318586006516	dimer interface [polypeptide binding]; other site
318586006517	anticodon binding site; other site
318586006518	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
318586006519	homodimer interface [polypeptide binding]; other site
318586006520	motif 1; other site
318586006521	active site
318586006522	motif 2; other site
318586006523	GAD domain; Region: GAD; pfam02938
318586006524	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
318586006525	active site
318586006526	motif 3; other site
318586006527	CAAX protease self-immunity; Region: Abi; pfam02517
318586006528	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
318586006529	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
318586006530	active site
318586006531	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
318586006532	FAD binding domain; Region: FAD_binding_4; pfam01565
318586006533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
318586006534	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
318586006535	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
318586006536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
318586006537	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
318586006538	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
318586006539	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
318586006540	metal ion-dependent adhesion site (MIDAS); other site
318586006541	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
318586006542	putative ADP-binding pocket [chemical binding]; other site
318586006543	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586006544	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586006545	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
318586006546	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
318586006547	active site
318586006548	hypothetical protein; Provisional; Region: PRK14013
318586006549	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
318586006550	MOFRL family; Region: MOFRL; pfam05161
318586006551	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
318586006552	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
318586006553	dimerization interface [polypeptide binding]; other site
318586006554	ligand binding site [chemical binding]; other site
318586006555	NADP binding site [chemical binding]; other site
318586006556	catalytic site [active]
318586006557	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
318586006558	dimer interface [polypeptide binding]; other site
318586006559	putative tRNA-binding site [nucleotide binding]; other site
318586006560	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
318586006561	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
318586006562	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
318586006563	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
318586006564	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586006565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586006566	homodimer interface [polypeptide binding]; other site
318586006567	catalytic residue [active]
318586006568	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
318586006569	ATP-grasp domain; Region: ATP-grasp; pfam02222
318586006570	AIR carboxylase; Region: AIRC; pfam00731
318586006571	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
318586006572	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
318586006573	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
318586006574	putative dimer interface [polypeptide binding]; other site
318586006575	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
318586006576	PUA-like domain; Region: PUA_2; pfam14306
318586006577	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586006578	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
318586006579	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586006580	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586006581	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586006582	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586006583	putative DNA binding site [nucleotide binding]; other site
318586006584	dimerization interface [polypeptide binding]; other site
318586006585	putative Zn2+ binding site [ion binding]; other site
318586006586	AsnC family; Region: AsnC_trans_reg; pfam01037
318586006587	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
318586006588	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
318586006589	Uncharacterized conserved protein [Function unknown]; Region: COG1565
318586006590	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
318586006591	Membrane fusogenic activity; Region: BMFP; pfam04380
318586006592	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
318586006593	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
318586006594	active site
318586006595	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
318586006596	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
318586006597	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586006598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586006599	DNA binding residues [nucleotide binding]
318586006600	Sporulation related domain; Region: SPOR; pfam05036
318586006601	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586006602	active site
318586006603	adenosine deaminase; Provisional; Region: PRK09358
318586006604	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
318586006605	active site
318586006606	phosphopentomutase; Provisional; Region: PRK05362
318586006607	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
318586006608	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
318586006609	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
318586006610	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
318586006611	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
318586006612	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
318586006613	active site
318586006614	catalytic motif [active]
318586006615	Zn binding site [ion binding]; other site
318586006616	malic enzyme; Reviewed; Region: PRK12862
318586006617	Malic enzyme, N-terminal domain; Region: malic; pfam00390
318586006618	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
318586006619	putative NAD(P) binding site [chemical binding]; other site
318586006620	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
318586006621	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
318586006622	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586006623	acyl-activating enzyme (AAE) consensus motif; other site
318586006624	AMP binding site [chemical binding]; other site
318586006625	active site
318586006626	CoA binding site [chemical binding]; other site
318586006627	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
318586006628	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
318586006629	hinge; other site
318586006630	active site
318586006631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586006632	S-adenosylmethionine binding site [chemical binding]; other site
318586006633	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
318586006634	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
318586006635	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
318586006636	pantothenate kinase; Reviewed; Region: PRK13318
318586006637	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
318586006638	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
318586006639	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
318586006640	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
318586006641	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586006642	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
318586006643	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586006644	hydrogenase 4 subunit D; Validated; Region: PRK06525
318586006645	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
318586006646	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
318586006647	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
318586006648	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
318586006649	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
318586006650	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
318586006651	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
318586006652	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
318586006653	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
318586006654	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
318586006655	4Fe-4S binding domain; Region: Fer4; pfam00037
318586006656	4Fe-4S binding domain; Region: Fer4; pfam00037
318586006657	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
318586006658	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
318586006659	NADH dehydrogenase subunit G; Validated; Region: PRK09130
318586006660	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586006661	catalytic loop [active]
318586006662	iron binding site [ion binding]; other site
318586006663	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
318586006664	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
318586006665	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
318586006666	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
318586006667	SLBB domain; Region: SLBB; pfam10531
318586006668	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
318586006669	Uncharacterized conserved protein [Function unknown]; Region: COG3743
318586006670	NADH dehydrogenase subunit E; Validated; Region: PRK07539
318586006671	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
318586006672	putative dimer interface [polypeptide binding]; other site
318586006673	[2Fe-2S] cluster binding site [ion binding]; other site
318586006674	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
318586006675	NADH dehydrogenase subunit D; Validated; Region: PRK06075
318586006676	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
318586006677	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
318586006678	NADH dehydrogenase subunit B; Validated; Region: PRK06411
318586006679	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
318586006680	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
318586006681	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
318586006682	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
318586006683	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
318586006684	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
318586006685	Uncharacterized conserved protein [Function unknown]; Region: COG3791
318586006686	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
318586006687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586006688	FeS/SAM binding site; other site
318586006689	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
318586006690	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
318586006691	A new structural DNA glycosylase; Region: AlkD_like; cd06561
318586006692	active site
318586006693	succinic semialdehyde dehydrogenase; Region: PLN02278
318586006694	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
318586006695	tetramerization interface [polypeptide binding]; other site
318586006696	NAD(P) binding site [chemical binding]; other site
318586006697	catalytic residues [active]
318586006698	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
318586006699	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
318586006700	B1 nucleotide binding pocket [chemical binding]; other site
318586006701	B2 nucleotide binding pocket [chemical binding]; other site
318586006702	CAS motifs; other site
318586006703	active site
318586006704	TM2 domain; Region: TM2; pfam05154
318586006705	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
318586006706	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
318586006707	putative tRNA-binding site [nucleotide binding]; other site
318586006708	B3/4 domain; Region: B3_4; pfam03483
318586006709	tRNA synthetase B5 domain; Region: B5; smart00874
318586006710	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
318586006711	dimer interface [polypeptide binding]; other site
318586006712	motif 1; other site
318586006713	motif 3; other site
318586006714	motif 2; other site
318586006715	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
318586006716	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
318586006717	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
318586006718	C-terminal domain interface [polypeptide binding]; other site
318586006719	GSH binding site (G-site) [chemical binding]; other site
318586006720	dimer interface [polypeptide binding]; other site
318586006721	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
318586006722	dimer interface [polypeptide binding]; other site
318586006723	N-terminal domain interface [polypeptide binding]; other site
318586006724	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
318586006725	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
318586006726	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586006727	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586006728	dimerization interface [polypeptide binding]; other site
318586006729	putative DNA binding site [nucleotide binding]; other site
318586006730	putative Zn2+ binding site [ion binding]; other site
318586006731	AsnC family; Region: AsnC_trans_reg; pfam01037
318586006732	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
318586006733	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
318586006734	COQ9; Region: COQ9; pfam08511
318586006735	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
318586006736	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
318586006737	NAD(P) binding site [chemical binding]; other site
318586006738	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
318586006739	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
318586006740	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
318586006741	dimer interface [polypeptide binding]; other site
318586006742	motif 1; other site
318586006743	active site
318586006744	motif 2; other site
318586006745	motif 3; other site
318586006746	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
318586006747	ArsC family; Region: ArsC; pfam03960
318586006748	catalytic residues [active]
318586006749	Cytochrome P450; Region: p450; cl12078
318586006750	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
318586006751	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
318586006752	23S rRNA binding site [nucleotide binding]; other site
318586006753	L21 binding site [polypeptide binding]; other site
318586006754	L13 binding site [polypeptide binding]; other site
318586006755	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
318586006756	pyruvate kinase; Provisional; Region: PRK06247
318586006757	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
318586006758	domain interfaces; other site
318586006759	active site
318586006760	N-formylglutamate amidohydrolase; Region: FGase; cl01522
318586006761	Mnt; Region: mnt; PHA01513
318586006762	Arc-like DNA binding domain; Region: Arc; pfam03869
318586006763	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586006764	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586006765	binding surface
318586006766	TPR motif; other site
318586006767	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
318586006768	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
318586006769	Sulfatase; Region: Sulfatase; cl17466
318586006770	choline-sulfatase; Region: chol_sulfatase; TIGR03417
318586006771	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
318586006772	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
318586006773	Transglycosylase; Region: Transgly; pfam00912
318586006774	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
318586006775	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586006776	C-terminal domain interface [polypeptide binding]; other site
318586006777	GSH binding site (G-site) [chemical binding]; other site
318586006778	dimer interface [polypeptide binding]; other site
318586006779	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
318586006780	N-terminal domain interface [polypeptide binding]; other site
318586006781	dimer interface [polypeptide binding]; other site
318586006782	substrate binding pocket (H-site) [chemical binding]; other site
318586006783	epoxyqueuosine reductase; Region: TIGR00276
318586006784	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
318586006785	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586006786	EamA-like transporter family; Region: EamA; pfam00892
318586006787	EamA-like transporter family; Region: EamA; cl17759
318586006788	Core-2/I-Branching enzyme; Region: Branch; pfam02485
318586006789	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
318586006790	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
318586006791	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586006792	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
318586006793	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
318586006794	NAD binding site [chemical binding]; other site
318586006795	homodimer interface [polypeptide binding]; other site
318586006796	active site
318586006797	substrate binding site [chemical binding]; other site
318586006798	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
318586006799	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
318586006800	active site
318586006801	tetramer interface; other site
318586006802	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
318586006803	active site
318586006804	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
318586006805	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
318586006806	Ligand binding site; other site
318586006807	oligomer interface; other site
318586006808	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
318586006809	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
318586006810	active site
318586006811	ABC-2 type transporter; Region: ABC2_membrane; cl17235
318586006812	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
318586006813	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
318586006814	nucleotide binding site [chemical binding]; other site
318586006815	NEF interaction site [polypeptide binding]; other site
318586006816	SBD interface [polypeptide binding]; other site
318586006817	chaperone protein DnaJ; Provisional; Region: PRK10767
318586006818	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
318586006819	HSP70 interaction site [polypeptide binding]; other site
318586006820	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
318586006821	substrate binding site [polypeptide binding]; other site
318586006822	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
318586006823	Zn binding sites [ion binding]; other site
318586006824	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
318586006825	dimer interface [polypeptide binding]; other site
318586006826	hypothetical protein; Reviewed; Region: PRK00024
318586006827	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
318586006828	MPN+ (JAMM) motif; other site
318586006829	Zinc-binding site [ion binding]; other site
318586006830	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
318586006831	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
318586006832	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
318586006833	[2Fe-2S] cluster binding site [ion binding]; other site
318586006834	cytochrome b; Provisional; Region: CYTB; MTH00191
318586006835	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
318586006836	intrachain domain interface; other site
318586006837	interchain domain interface [polypeptide binding]; other site
318586006838	heme bH binding site [chemical binding]; other site
318586006839	Qi binding site; other site
318586006840	heme bL binding site [chemical binding]; other site
318586006841	Qo binding site; other site
318586006842	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
318586006843	interchain domain interface [polypeptide binding]; other site
318586006844	intrachain domain interface; other site
318586006845	Qi binding site; other site
318586006846	Qo binding site; other site
318586006847	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
318586006848	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
318586006849	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586006850	substrate binding site [chemical binding]; other site
318586006851	dimer interface [polypeptide binding]; other site
318586006852	ATP binding site [chemical binding]; other site
318586006853	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
318586006854	tandem repeat interface [polypeptide binding]; other site
318586006855	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
318586006856	oligomer interface [polypeptide binding]; other site
318586006857	active site residues [active]
318586006858	short chain dehydrogenase; Provisional; Region: PRK09134
318586006859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586006860	NAD(P) binding site [chemical binding]; other site
318586006861	active site
318586006862	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
318586006863	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
318586006864	GIY-YIG motif/motif A; other site
318586006865	active site
318586006866	catalytic site [active]
318586006867	putative DNA binding site [nucleotide binding]; other site
318586006868	metal binding site [ion binding]; metal-binding site
318586006869	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
318586006870	Protein of unknown function (DUF330); Region: DUF330; cl01135
318586006871	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
318586006872	mce related protein; Region: MCE; pfam02470
318586006873	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
318586006874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586006875	Walker A/P-loop; other site
318586006876	ATP binding site [chemical binding]; other site
318586006877	Q-loop/lid; other site
318586006878	ABC transporter signature motif; other site
318586006879	Walker B; other site
318586006880	D-loop; other site
318586006881	H-loop/switch region; other site
318586006882	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
318586006883	Permease; Region: Permease; pfam02405
318586006884	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586006885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586006886	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
318586006887	putative dimerization interface [polypeptide binding]; other site
318586006888	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
318586006889	FAD binding site [chemical binding]; other site
318586006890	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
318586006891	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
318586006892	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
318586006893	dimer interface [polypeptide binding]; other site
318586006894	active site
318586006895	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586006896	catalytic residues [active]
318586006897	substrate binding site [chemical binding]; other site
318586006898	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
318586006899	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
318586006900	AsnC family; Region: AsnC_trans_reg; pfam01037
318586006901	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
318586006902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586006903	S-adenosylmethionine binding site [chemical binding]; other site
318586006904	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
318586006905	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586006906	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586006907	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
318586006908	catalytic triad [active]
318586006909	dimer interface [polypeptide binding]; other site
318586006910	Predicted transcriptional regulators [Transcription]; Region: COG1733
318586006911	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
318586006912	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
318586006913	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
318586006914	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586006915	YceI-like domain; Region: YceI; pfam04264
318586006916	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
318586006917	putative C-terminal domain interface [polypeptide binding]; other site
318586006918	putative GSH binding site (G-site) [chemical binding]; other site
318586006919	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586006920	putative dimer interface [polypeptide binding]; other site
318586006921	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
318586006922	dimer interface [polypeptide binding]; other site
318586006923	N-terminal domain interface [polypeptide binding]; other site
318586006924	putative substrate binding pocket (H-site) [chemical binding]; other site
318586006925	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586006926	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
318586006927	active site
318586006928	HIGH motif; other site
318586006929	nucleotide binding site [chemical binding]; other site
318586006930	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
318586006931	active site
318586006932	KMSKS motif; other site
318586006933	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
318586006934	tRNA binding surface [nucleotide binding]; other site
318586006935	anticodon binding site; other site
318586006936	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
318586006937	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
318586006938	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
318586006939	active site
318586006940	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
318586006941	putative active site [active]
318586006942	Domain of unknown function (DUF4202); Region: DUF4202; pfam13875
318586006943	NnrU protein; Region: NnrU; pfam07298
318586006944	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586006945	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
318586006946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586006947	S-adenosylmethionine binding site [chemical binding]; other site
318586006948	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
318586006949	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
318586006950	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586006951	inhibitor-cofactor binding pocket; inhibition site
318586006952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586006953	catalytic residue [active]
318586006954	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
318586006955	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
318586006956	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
318586006957	MoaE homodimer interface [polypeptide binding]; other site
318586006958	MoaD interaction [polypeptide binding]; other site
318586006959	active site residues [active]
318586006960	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
318586006961	MoaE interaction surface [polypeptide binding]; other site
318586006962	MoeB interaction surface [polypeptide binding]; other site
318586006963	thiocarboxylated glycine; other site
318586006964	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
318586006965	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
318586006966	DNA binding residues [nucleotide binding]
318586006967	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
318586006968	dimer interface [polypeptide binding]; other site
318586006969	putative metal binding site [ion binding]; other site
318586006970	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
318586006971	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
318586006972	metal-binding site [ion binding]
318586006973	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
318586006974	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586006975	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
318586006976	glycine dehydrogenase; Provisional; Region: PRK05367
318586006977	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
318586006978	tetramer interface [polypeptide binding]; other site
318586006979	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586006980	catalytic residue [active]
318586006981	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
318586006982	tetramer interface [polypeptide binding]; other site
318586006983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586006984	catalytic residue [active]
318586006985	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
318586006986	lipoyl attachment site [posttranslational modification]; other site
318586006987	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
318586006988	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
318586006989	short chain dehydrogenase; Provisional; Region: PRK08339
318586006990	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
318586006991	putative NAD(P) binding site [chemical binding]; other site
318586006992	putative active site [active]
318586006993	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586006994	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
318586006995	dimer interface [polypeptide binding]; other site
318586006996	phosphorylation site [posttranslational modification]
318586006997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586006998	ATP binding site [chemical binding]; other site
318586006999	Mg2+ binding site [ion binding]; other site
318586007000	G-X-G motif; other site
318586007001	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
318586007002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586007003	active site
318586007004	phosphorylation site [posttranslational modification]
318586007005	intermolecular recognition site; other site
318586007006	dimerization interface [polypeptide binding]; other site
318586007007	Uncharacterized conserved protein [Function unknown]; Region: COG3287
318586007008	FIST N domain; Region: FIST; pfam08495
318586007009	FIST C domain; Region: FIST_C; pfam10442
318586007010	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586007011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586007012	active site
318586007013	phosphorylation site [posttranslational modification]
318586007014	intermolecular recognition site; other site
318586007015	dimerization interface [polypeptide binding]; other site
318586007016	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586007017	DNA binding residues [nucleotide binding]
318586007018	dimerization interface [polypeptide binding]; other site
318586007019	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586007020	membrane-bound complex binding site; other site
318586007021	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586007022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586007023	dimer interface [polypeptide binding]; other site
318586007024	conserved gate region; other site
318586007025	putative PBP binding loops; other site
318586007026	ABC-ATPase subunit interface; other site
318586007027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586007028	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
318586007029	Walker A/P-loop; other site
318586007030	ATP binding site [chemical binding]; other site
318586007031	Q-loop/lid; other site
318586007032	ABC transporter signature motif; other site
318586007033	Walker B; other site
318586007034	D-loop; other site
318586007035	H-loop/switch region; other site
318586007036	Predicted secreted protein [Function unknown]; Region: COG5501
318586007037	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
318586007038	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
318586007039	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
318586007040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586007041	FeS/SAM binding site; other site
318586007042	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
318586007043	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
318586007044	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
318586007045	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
318586007046	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
318586007047	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586007048	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
318586007049	putative binding site; other site
318586007050	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
318586007051	MG2 domain; Region: A2M_N; pfam01835
318586007052	Alpha-2-macroglobulin family; Region: A2M; pfam00207
318586007053	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
318586007054	surface patch; other site
318586007055	thioester region; other site
318586007056	specificity defining residues; other site
318586007057	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
318586007058	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586007059	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
318586007060	DNA-binding interface [nucleotide binding]; DNA binding site
318586007061	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
318586007062	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586007063	NAD(P) binding site [chemical binding]; other site
318586007064	catalytic residues [active]
318586007065	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
318586007066	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
318586007067	NAD binding site [chemical binding]; other site
318586007068	substrate binding site [chemical binding]; other site
318586007069	catalytic Zn binding site [ion binding]; other site
318586007070	tetramer interface [polypeptide binding]; other site
318586007071	structural Zn binding site [ion binding]; other site
318586007072	Protein of unknown function (DUF779); Region: DUF779; cl01432
318586007073	Uncharacterized conserved protein [Function unknown]; Region: COG2835
318586007074	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
318586007075	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
318586007076	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
318586007077	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
318586007078	putative catalytic site [active]
318586007079	putative phosphate binding site [ion binding]; other site
318586007080	active site
318586007081	metal binding site A [ion binding]; metal-binding site
318586007082	DNA binding site [nucleotide binding]
318586007083	putative AP binding site [nucleotide binding]; other site
318586007084	putative metal binding site B [ion binding]; other site
318586007085	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
318586007086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586007087	active site
318586007088	phosphorylation site [posttranslational modification]
318586007089	intermolecular recognition site; other site
318586007090	dimerization interface [polypeptide binding]; other site
318586007091	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586007092	DNA binding site [nucleotide binding]
318586007093	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
318586007094	dimerization interface [polypeptide binding]; other site
318586007095	active site
318586007096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
318586007097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586007098	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586007099	NAD(P) binding site [chemical binding]; other site
318586007100	active site
318586007101	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
318586007102	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
318586007103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
318586007104	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
318586007105	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
318586007106	putative metal binding site [ion binding]; other site
318586007107	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
318586007108	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
318586007109	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
318586007110	putative active site [active]
318586007111	putative metal binding site [ion binding]; other site
318586007112	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
318586007113	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
318586007114	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
318586007115	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
318586007116	Isochorismatase family; Region: Isochorismatase; pfam00857
318586007117	catalytic triad [active]
318586007118	conserved cis-peptide bond; other site
318586007119	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
318586007120	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586007121	NAD(P) binding site [chemical binding]; other site
318586007122	active site
318586007123	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
318586007124	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
318586007125	acyl-activating enzyme (AAE) consensus motif; other site
318586007126	active site
318586007127	AMP binding site [chemical binding]; other site
318586007128	substrate binding site [chemical binding]; other site
318586007129	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
318586007130	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
318586007131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586007132	Coenzyme A binding pocket [chemical binding]; other site
318586007133	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
318586007134	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
318586007135	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
318586007136	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
318586007137	Replication protein C N-terminal domain; Region: RP-C; pfam03428
318586007138	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
318586007139	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
318586007140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586007141	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
318586007142	Walker A motif; other site
318586007143	ATP binding site [chemical binding]; other site
318586007144	Walker B motif; other site
318586007145	arginine finger; other site
318586007146	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
318586007147	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
318586007148	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586007149	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586007150	non-specific DNA binding site [nucleotide binding]; other site
318586007151	salt bridge; other site
318586007152	sequence-specific DNA binding site [nucleotide binding]; other site
318586007153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
318586007154	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586007155	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
318586007156	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
318586007157	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586007158	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
318586007159	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
318586007160	putative active site [active]
318586007161	putative metal binding site [ion binding]; other site
318586007162	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
318586007163	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
318586007164	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
318586007165	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586007166	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
318586007167	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
318586007168	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586007169	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
318586007170	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586007171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586007172	Walker A/P-loop; other site
318586007173	ATP binding site [chemical binding]; other site
318586007174	Q-loop/lid; other site
318586007175	ABC transporter signature motif; other site
318586007176	Walker B; other site
318586007177	D-loop; other site
318586007178	H-loop/switch region; other site
318586007179	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586007180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586007181	sequence-specific DNA binding site [nucleotide binding]; other site
318586007182	salt bridge; other site
318586007183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586007184	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
318586007185	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586007186	active site
318586007187	catalytic residues [active]
318586007188	DNA binding site [nucleotide binding]
318586007189	Int/Topo IB signature motif; other site
318586007190	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
318586007191	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586007192	active site
318586007193	catalytic residues [active]
318586007194	DNA binding site [nucleotide binding]
318586007195	Int/Topo IB signature motif; other site
318586007196	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586007197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586007198	non-specific DNA binding site [nucleotide binding]; other site
318586007199	salt bridge; other site
318586007200	sequence-specific DNA binding site [nucleotide binding]; other site
318586007201	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
318586007202	Predicted permeases [General function prediction only]; Region: RarD; COG2962
318586007203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
318586007204	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
318586007205	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
318586007206	Trp docking motif [polypeptide binding]; other site
318586007207	active site
318586007208	PQQ-like domain; Region: PQQ_2; pfam13360
318586007209	GTP-binding protein Der; Reviewed; Region: PRK00093
318586007210	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
318586007211	G1 box; other site
318586007212	GTP/Mg2+ binding site [chemical binding]; other site
318586007213	Switch I region; other site
318586007214	G2 box; other site
318586007215	Switch II region; other site
318586007216	G3 box; other site
318586007217	G4 box; other site
318586007218	G5 box; other site
318586007219	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
318586007220	G1 box; other site
318586007221	GTP/Mg2+ binding site [chemical binding]; other site
318586007222	Switch I region; other site
318586007223	G2 box; other site
318586007224	G3 box; other site
318586007225	Switch II region; other site
318586007226	G4 box; other site
318586007227	G5 box; other site
318586007228	seryl-tRNA synthetase; Provisional; Region: PRK05431
318586007229	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
318586007230	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
318586007231	dimer interface [polypeptide binding]; other site
318586007232	active site
318586007233	motif 1; other site
318586007234	motif 2; other site
318586007235	motif 3; other site
318586007236	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
318586007237	membrane ATPase/protein kinase; Provisional; Region: PRK09435
318586007238	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
318586007239	Walker A; other site
318586007240	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
318586007241	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
318586007242	DNA binding site [nucleotide binding]
318586007243	active site
318586007244	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
318586007245	conserved hypothetical protein; Region: TIGR02270
318586007246	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
318586007247	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
318586007248	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212
318586007249	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
318586007250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586007251	Walker A motif; other site
318586007252	ATP binding site [chemical binding]; other site
318586007253	Walker B motif; other site
318586007254	arginine finger; other site
318586007255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586007256	Walker A motif; other site
318586007257	ATP binding site [chemical binding]; other site
318586007258	Walker B motif; other site
318586007259	arginine finger; other site
318586007260	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
318586007261	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
318586007262	Catalytic domain of Protein Kinases; Region: PKc; cd00180
318586007263	active site
318586007264	ATP binding site [chemical binding]; other site
318586007265	substrate binding site [chemical binding]; other site
318586007266	activation loop (A-loop); other site
318586007267	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
318586007268	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
318586007269	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
318586007270	Protein of unknown function (DUF877); Region: DUF877; pfam05943
318586007271	Protein of unknown function (DUF796); Region: DUF796; pfam05638
318586007272	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
318586007273	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
318586007274	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
318586007275	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
318586007276	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
318586007277	phosphopeptide binding site; other site
318586007278	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
318586007279	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
318586007280	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
318586007281	hypothetical protein; Provisional; Region: PRK07033
318586007282	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
318586007283	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586007284	ligand binding site [chemical binding]; other site
318586007285	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
318586007286	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
318586007287	G1 box; other site
318586007288	GTP/Mg2+ binding site [chemical binding]; other site
318586007289	G2 box; other site
318586007290	G3 box; other site
318586007291	Switch II region; other site
318586007292	G4 box; other site
318586007293	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
318586007294	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
318586007295	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
318586007296	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
318586007297	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
318586007298	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
318586007299	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
318586007300	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
318586007301	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
318586007302	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
318586007303	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
318586007304	active site
318586007305	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
318586007306	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586007307	ligand binding site [chemical binding]; other site
318586007308	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
318586007309	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
318586007310	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
318586007311	haemagglutination activity domain; Region: Haemagg_act; smart00912
318586007312	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
318586007313	Caspase domain; Region: Peptidase_C14; pfam00656
318586007314	substrate pocket [chemical binding]; other site
318586007315	active site
318586007316	proteolytic cleavage site; other site
318586007317	dimer interface [polypeptide binding]; other site
318586007318	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
318586007319	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
318586007320	Hint domain; Region: Hint_2; pfam13403
318586007321	LytTr DNA-binding domain; Region: LytTR; smart00850
318586007322	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
318586007323	Cation efflux family; Region: Cation_efflux; cl00316
318586007324	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
318586007325	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586007326	Walker A/P-loop; other site
318586007327	ATP binding site [chemical binding]; other site
318586007328	Q-loop/lid; other site
318586007329	ABC transporter signature motif; other site
318586007330	Walker B; other site
318586007331	D-loop; other site
318586007332	H-loop/switch region; other site
318586007333	TOBE domain; Region: TOBE_2; pfam08402
318586007334	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586007335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586007336	dimer interface [polypeptide binding]; other site
318586007337	conserved gate region; other site
318586007338	putative PBP binding loops; other site
318586007339	ABC-ATPase subunit interface; other site
318586007340	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
318586007341	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586007342	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586007343	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586007344	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
318586007345	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
318586007346	putative active site [active]
318586007347	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
318586007348	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
318586007349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586007350	DNA-binding site [nucleotide binding]; DNA binding site
318586007351	UTRA domain; Region: UTRA; pfam07702
318586007352	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
318586007353	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
318586007354	dimer interface [polypeptide binding]; other site
318586007355	active site
318586007356	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
318586007357	dimer interface [polypeptide binding]; other site
318586007358	active site
318586007359	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
318586007360	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586007361	active site
318586007362	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
318586007363	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
318586007364	ligand binding site [chemical binding]; other site
318586007365	flexible hinge region; other site
318586007366	putative switch regulator; other site
318586007367	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
318586007368	non-specific DNA interactions [nucleotide binding]; other site
318586007369	DNA binding site [nucleotide binding]
318586007370	sequence specific DNA binding site [nucleotide binding]; other site
318586007371	putative cAMP binding site [chemical binding]; other site
318586007372	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
318586007373	Subunit I/III interface [polypeptide binding]; other site
318586007374	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
318586007375	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
318586007376	metal ion-dependent adhesion site (MIDAS); other site
318586007377	MoxR-like ATPases [General function prediction only]; Region: COG0714
318586007378	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
318586007379	Walker A motif; other site
318586007380	ATP binding site [chemical binding]; other site
318586007381	Walker B motif; other site
318586007382	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
318586007383	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
318586007384	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
318586007385	Binuclear center (active site) [active]
318586007386	K-pathway; other site
318586007387	Putative proton exit pathway; other site
318586007388	Putative water exit pathway; other site
318586007389	Cytochrome c; Region: Cytochrom_C; pfam00034
318586007390	ApbE family; Region: ApbE; pfam02424
318586007391	FMN-binding domain; Region: FMN_bind; cl01081
318586007392	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
318586007393	4Fe-4S binding domain; Region: Fer4_5; pfam12801
318586007394	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
318586007395	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
318586007396	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
318586007397	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
318586007398	active site
318586007399	SAM binding site [chemical binding]; other site
318586007400	homodimer interface [polypeptide binding]; other site
318586007401	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
318586007402	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
318586007403	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
318586007404	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
318586007405	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
318586007406	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586007407	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586007408	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586007409	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
318586007410	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
318586007411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586007412	FeS/SAM binding site; other site
318586007413	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
318586007414	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
318586007415	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
318586007416	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
318586007417	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
318586007418	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
318586007419	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
318586007420	dimer interface [polypeptide binding]; other site
318586007421	active site
318586007422	heme binding site [chemical binding]; other site
318586007423	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
318586007424	primosome assembly protein PriA; Validated; Region: PRK05580
318586007425	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586007426	ATP binding site [chemical binding]; other site
318586007427	putative Mg++ binding site [ion binding]; other site
318586007428	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
318586007429	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
318586007430	active site
318586007431	intersubunit interactions; other site
318586007432	catalytic residue [active]
318586007433	Protein of unknown function, DUF484; Region: DUF484; cl17449
318586007434	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
318586007435	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586007436	active site
318586007437	DNA binding site [nucleotide binding]
318586007438	Int/Topo IB signature motif; other site
318586007439	hypothetical protein; Provisional; Region: PRK10621
318586007440	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586007441	L-asparaginase II; Region: Asparaginase_II; pfam06089
318586007442	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586007443	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
318586007444	phosphoglyceromutase; Provisional; Region: PRK05434
318586007445	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
318586007446	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
318586007447	Peptidase family M23; Region: Peptidase_M23; pfam01551
318586007448	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
318586007449	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
318586007450	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
318586007451	protein binding site [polypeptide binding]; other site
318586007452	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
318586007453	Catalytic dyad [active]
318586007454	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
318586007455	putative active site [active]
318586007456	Ap4A binding site [chemical binding]; other site
318586007457	nudix motif; other site
318586007458	putative metal binding site [ion binding]; other site
318586007459	Transglycosylase SLT domain; Region: SLT_2; pfam13406
318586007460	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586007461	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586007462	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586007463	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
318586007464	putative deacylase active site [active]
318586007465	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
318586007466	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
318586007467	trimer interface [polypeptide binding]; other site
318586007468	active site
318586007469	substrate binding site [chemical binding]; other site
318586007470	CoA binding site [chemical binding]; other site
318586007471	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
318586007472	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
318586007473	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
318586007474	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
318586007475	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
318586007476	substrate binding site [chemical binding]; other site
318586007477	ligand binding site [chemical binding]; other site
318586007478	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
318586007479	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
318586007480	substrate binding site [chemical binding]; other site
318586007481	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
318586007482	Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490
318586007483	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
318586007484	putative FMN binding site [chemical binding]; other site
318586007485	Domain of unknown function (DU1801); Region: DUF1801; cl17490
318586007486	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
318586007487	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
318586007488	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
318586007489	homodimer interface [polypeptide binding]; other site
318586007490	Walker A motif; other site
318586007491	ATP binding site [chemical binding]; other site
318586007492	hydroxycobalamin binding site [chemical binding]; other site
318586007493	Walker B motif; other site
318586007494	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
318586007495	dimer interface [polypeptide binding]; other site
318586007496	[2Fe-2S] cluster binding site [ion binding]; other site
318586007497	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
318586007498	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
318586007499	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
318586007500	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
318586007501	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
318586007502	precorrin-3B synthase; Region: CobG; TIGR02435
318586007503	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
318586007504	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
318586007505	Precorrin-8X methylmutase; Region: CbiC; pfam02570
318586007506	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
318586007507	active site
318586007508	SAM binding site [chemical binding]; other site
318586007509	homodimer interface [polypeptide binding]; other site
318586007510	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
318586007511	active site
318586007512	SAM binding site [chemical binding]; other site
318586007513	homodimer interface [polypeptide binding]; other site
318586007514	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
318586007515	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
318586007516	active site
318586007517	putative homodimer interface [polypeptide binding]; other site
318586007518	SAM binding site [chemical binding]; other site
318586007519	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
318586007520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
318586007521	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
318586007522	active site
318586007523	SAM binding site [chemical binding]; other site
318586007524	homodimer interface [polypeptide binding]; other site
318586007525	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
318586007526	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
318586007527	conserved cys residue [active]
318586007528	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
318586007529	active site
318586007530	SAM binding site [chemical binding]; other site
318586007531	homodimer interface [polypeptide binding]; other site
318586007532	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
318586007533	Cytochrome C' Region: Cytochrom_C_2; pfam01322
318586007534	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
318586007535	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
318586007536	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
318586007537	CAP-like domain; other site
318586007538	active site
318586007539	primary dimer interface [polypeptide binding]; other site
318586007540	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
318586007541	short chain dehydrogenase; Provisional; Region: PRK05993
318586007542	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
318586007543	NADP binding site [chemical binding]; other site
318586007544	active site
318586007545	steroid binding site; other site
318586007546	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
318586007547	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
318586007548	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
318586007549	Ligand binding site [chemical binding]; other site
318586007550	Electron transfer flavoprotein domain; Region: ETF; pfam01012
318586007551	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
318586007552	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
318586007553	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
318586007554	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
318586007555	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586007556	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586007557	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
318586007558	dihydroorotase; Validated; Region: PRK09059
318586007559	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586007560	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
318586007561	active site
318586007562	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
318586007563	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
318586007564	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
318586007565	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
318586007566	active site
318586007567	SAM binding site [chemical binding]; other site
318586007568	homodimer interface [polypeptide binding]; other site
318586007569	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
318586007570	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
318586007571	CPxP  motif; other site
318586007572	Predicted permeases [General function prediction only]; Region: COG0679
318586007573	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
318586007574	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586007575	substrate binding site [chemical binding]; other site
318586007576	oxyanion hole (OAH) forming residues; other site
318586007577	trimer interface [polypeptide binding]; other site
318586007578	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586007579	EamA-like transporter family; Region: EamA; pfam00892
318586007580	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
318586007581	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
318586007582	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
318586007583	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
318586007584	acyl-activating enzyme (AAE) consensus motif; other site
318586007585	AMP binding site [chemical binding]; other site
318586007586	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
318586007587	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
318586007588	Uncharacterized conserved protein [Function unknown]; Region: COG3391
318586007589	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
318586007590	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586007591	intersubunit interface [polypeptide binding]; other site
318586007592	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586007593	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586007594	dimer interface [polypeptide binding]; other site
318586007595	putative PBP binding regions; other site
318586007596	ABC-ATPase subunit  interface; other site
318586007597	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586007598	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586007599	Walker A/P-loop; other site
318586007600	ATP binding site [chemical binding]; other site
318586007601	Q-loop/lid; other site
318586007602	ABC transporter signature motif; other site
318586007603	Walker B; other site
318586007604	D-loop; other site
318586007605	H-loop/switch region; other site
318586007606	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
318586007607	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
318586007608	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
318586007609	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
318586007610	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
318586007611	substrate binding site [chemical binding]; other site
318586007612	hexamer interface [polypeptide binding]; other site
318586007613	metal binding site [ion binding]; metal-binding site
318586007614	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
318586007615	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
318586007616	dimerization interface [polypeptide binding]; other site
318586007617	domain crossover interface; other site
318586007618	redox-dependent activation switch; other site
318586007619	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
318586007620	putative active site [active]
318586007621	putative CoA binding site [chemical binding]; other site
318586007622	nudix motif; other site
318586007623	metal binding site [ion binding]; metal-binding site
318586007624	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
318586007625	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
318586007626	active site
318586007627	NTP binding site [chemical binding]; other site
318586007628	metal binding triad [ion binding]; metal-binding site
318586007629	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
318586007630	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586007631	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586007632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586007633	Walker A/P-loop; other site
318586007634	ATP binding site [chemical binding]; other site
318586007635	Q-loop/lid; other site
318586007636	ABC transporter signature motif; other site
318586007637	Walker B; other site
318586007638	D-loop; other site
318586007639	H-loop/switch region; other site
318586007640	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
318586007641	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586007642	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
318586007643	putative C-terminal domain interface [polypeptide binding]; other site
318586007644	putative GSH binding site (G-site) [chemical binding]; other site
318586007645	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586007646	putative dimer interface [polypeptide binding]; other site
318586007647	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586007648	N-terminal domain interface [polypeptide binding]; other site
318586007649	dimer interface [polypeptide binding]; other site
318586007650	substrate binding pocket (H-site) [chemical binding]; other site
318586007651	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
318586007652	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586007653	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
318586007654	ferrochelatase; Reviewed; Region: hemH; PRK00035
318586007655	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
318586007656	C-terminal domain interface [polypeptide binding]; other site
318586007657	active site
318586007658	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
318586007659	active site
318586007660	N-terminal domain interface [polypeptide binding]; other site
318586007661	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
318586007662	Methyltransferase domain; Region: Methyltransf_11; pfam08241
318586007663	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
318586007664	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
318586007665	GSH binding site [chemical binding]; other site
318586007666	catalytic residues [active]
318586007667	nitrilase; Region: PLN02798
318586007668	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
318586007669	putative active site [active]
318586007670	catalytic triad [active]
318586007671	dimer interface [polypeptide binding]; other site
318586007672	MarR family; Region: MarR_2; pfam12802
318586007673	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
318586007674	Methyltransferase domain; Region: Methyltransf_11; pfam08241
318586007675	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
318586007676	ribosome maturation protein RimP; Reviewed; Region: PRK00092
318586007677	Sm and related proteins; Region: Sm_like; cl00259
318586007678	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
318586007679	putative oligomer interface [polypeptide binding]; other site
318586007680	putative RNA binding site [nucleotide binding]; other site
318586007681	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
318586007682	NusA N-terminal domain; Region: NusA_N; pfam08529
318586007683	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
318586007684	RNA binding site [nucleotide binding]; other site
318586007685	homodimer interface [polypeptide binding]; other site
318586007686	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
318586007687	G-X-X-G motif; other site
318586007688	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
318586007689	G-X-X-G motif; other site
318586007690	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
318586007691	hypothetical protein; Provisional; Region: PRK09190
318586007692	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
318586007693	putative RNA binding cleft [nucleotide binding]; other site
318586007694	translation initiation factor IF-2; Region: IF-2; TIGR00487
318586007695	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
318586007696	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
318586007697	G1 box; other site
318586007698	putative GEF interaction site [polypeptide binding]; other site
318586007699	GTP/Mg2+ binding site [chemical binding]; other site
318586007700	Switch I region; other site
318586007701	G2 box; other site
318586007702	G3 box; other site
318586007703	Switch II region; other site
318586007704	G4 box; other site
318586007705	G5 box; other site
318586007706	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
318586007707	Translation-initiation factor 2; Region: IF-2; pfam11987
318586007708	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
318586007709	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
318586007710	active site
318586007711	8-oxo-dGMP binding site [chemical binding]; other site
318586007712	nudix motif; other site
318586007713	metal binding site [ion binding]; metal-binding site
318586007714	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
318586007715	heterotetramer interface [polypeptide binding]; other site
318586007716	active site pocket [active]
318586007717	cleavage site
318586007718	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
318586007719	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
318586007720	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
318586007721	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
318586007722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586007723	nucleotide binding region [chemical binding]; other site
318586007724	ATP-binding site [chemical binding]; other site
318586007725	SEC-C motif; Region: SEC-C; pfam02810
318586007726	osmolarity response regulator; Provisional; Region: ompR; PRK09468
318586007727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586007728	active site
318586007729	phosphorylation site [posttranslational modification]
318586007730	intermolecular recognition site; other site
318586007731	dimerization interface [polypeptide binding]; other site
318586007732	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586007733	DNA binding site [nucleotide binding]
318586007734	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
318586007735	MarR family; Region: MarR_2; pfam12802
318586007736	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
318586007737	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
318586007738	homodimer interface [polypeptide binding]; other site
318586007739	substrate-cofactor binding pocket; other site
318586007740	catalytic residue [active]
318586007741	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
318586007742	active site
318586007743	phosphorylation site [posttranslational modification]
318586007744	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
318586007745	30S subunit binding site; other site
318586007746	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
318586007747	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
318586007748	Walker A/P-loop; other site
318586007749	ATP binding site [chemical binding]; other site
318586007750	Q-loop/lid; other site
318586007751	ABC transporter signature motif; other site
318586007752	Walker B; other site
318586007753	D-loop; other site
318586007754	H-loop/switch region; other site
318586007755	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
318586007756	OstA-like protein; Region: OstA; pfam03968
318586007757	KpsF/GutQ family protein; Region: kpsF; TIGR00393
318586007758	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
318586007759	putative active site [active]
318586007760	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
318586007761	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
318586007762	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
318586007763	catalytic site [active]
318586007764	putative active site [active]
318586007765	putative substrate binding site [chemical binding]; other site
318586007766	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
318586007767	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586007768	N-terminal plug; other site
318586007769	ligand-binding site [chemical binding]; other site
318586007770	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586007771	Helix-turn-helix; Region: HTH_3; pfam01381
318586007772	non-specific DNA binding site [nucleotide binding]; other site
318586007773	salt bridge; other site
318586007774	sequence-specific DNA binding site [nucleotide binding]; other site
318586007775	putative transporter; Provisional; Region: PRK11660
318586007776	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
318586007777	Sulfate transporter family; Region: Sulfate_transp; pfam00916
318586007778	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
318586007779	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
318586007780	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
318586007781	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
318586007782	putative active site [active]
318586007783	putative substrate binding site [chemical binding]; other site
318586007784	putative cosubstrate binding site; other site
318586007785	catalytic site [active]
318586007786	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
318586007787	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
318586007788	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
318586007789	homodimer interface [polypeptide binding]; other site
318586007790	NADP binding site [chemical binding]; other site
318586007791	substrate binding site [chemical binding]; other site
318586007792	patatin-related protein; Region: TIGR03607
318586007793	Patatin-like phospholipase; Region: Patatin; pfam01734
318586007794	nucleophile elbow; other site
318586007795	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
318586007796	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232
318586007797	putative active site [active]
318586007798	Zn binding site [ion binding]; other site
318586007799	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
318586007800	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
318586007801	putative active site [active]
318586007802	metal binding site [ion binding]; metal-binding site
318586007803	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
318586007804	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
318586007805	N- and C-terminal domain interface [polypeptide binding]; other site
318586007806	active site
318586007807	MgATP binding site [chemical binding]; other site
318586007808	catalytic site [active]
318586007809	metal binding site [ion binding]; metal-binding site
318586007810	glycerol binding site [chemical binding]; other site
318586007811	homotetramer interface [polypeptide binding]; other site
318586007812	homodimer interface [polypeptide binding]; other site
318586007813	FBP binding site [chemical binding]; other site
318586007814	protein IIAGlc interface [polypeptide binding]; other site
318586007815	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
318586007816	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
318586007817	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
318586007818	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
318586007819	kynureninase; Region: kynureninase; TIGR01814
318586007820	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586007821	catalytic residue [active]
318586007822	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586007823	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586007824	DNA binding site [nucleotide binding]
318586007825	domain linker motif; other site
318586007826	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
318586007827	ligand binding site [chemical binding]; other site
318586007828	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
318586007829	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
318586007830	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586007831	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586007832	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
318586007833	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
318586007834	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
318586007835	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
318586007836	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
318586007837	FHIPEP family; Region: FHIPEP; pfam00771
318586007838	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
318586007839	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
318586007840	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
318586007841	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
318586007842	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
318586007843	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586007844	active site
318586007845	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
318586007846	Phage capsid family; Region: Phage_capsid; pfam05065
318586007847	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
318586007848	Phage portal protein; Region: Phage_portal; pfam04860
318586007849	SPRY domain; Region: SPRY; cl02614
318586007850	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
318586007851	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586007852	active site
318586007853	catalytic residues [active]
318586007854	DNA binding site [nucleotide binding]
318586007855	Int/Topo IB signature motif; other site
318586007856	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
318586007857	Uncharacterized conserved protein [Function unknown]; Region: COG3334
318586007858	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
318586007859	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
318586007860	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
318586007861	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
318586007862	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
318586007863	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
318586007864	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586007865	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586007866	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586007867	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586007868	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586007869	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586007870	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
318586007871	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
318586007872	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586007873	ATP binding site [chemical binding]; other site
318586007874	putative Mg++ binding site [ion binding]; other site
318586007875	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586007876	nucleotide binding region [chemical binding]; other site
318586007877	ATP-binding site [chemical binding]; other site
318586007878	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
318586007879	HRDC domain; Region: HRDC; pfam00570
318586007880	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586007881	active site
318586007882	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
318586007883	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
318586007884	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
318586007885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
318586007886	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
318586007887	Beta-lactamase; Region: Beta-lactamase; pfam00144
318586007888	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
318586007889	beta-ketothiolase; Provisional; Region: PRK09051
318586007890	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586007891	dimer interface [polypeptide binding]; other site
318586007892	active site
318586007893	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
318586007894	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
318586007895	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586007896	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
318586007897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586007898	dimer interface [polypeptide binding]; other site
318586007899	conserved gate region; other site
318586007900	putative PBP binding loops; other site
318586007901	ABC-ATPase subunit interface; other site
318586007902	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
318586007903	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586007904	Walker A/P-loop; other site
318586007905	ATP binding site [chemical binding]; other site
318586007906	Q-loop/lid; other site
318586007907	ABC transporter signature motif; other site
318586007908	Walker B; other site
318586007909	D-loop; other site
318586007910	H-loop/switch region; other site
318586007911	TOBE domain; Region: TOBE; cl01440
318586007912	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586007913	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586007914	catalytic residue [active]
318586007915	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
318586007916	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
318586007917	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586007918	hypothetical protein; Provisional; Region: PRK06102
318586007919	Amidase; Region: Amidase; cl11426
318586007920	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
318586007921	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586007922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586007923	homodimer interface [polypeptide binding]; other site
318586007924	catalytic residue [active]
318586007925	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
318586007926	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
318586007927	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
318586007928	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
318586007929	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
318586007930	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
318586007931	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586007932	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586007933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586007934	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
318586007935	putative substrate translocation pore; other site
318586007936	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
318586007937	MarR family; Region: MarR_2; pfam12802
318586007938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
318586007939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
318586007940	Family of unknown function (DUF490); Region: DUF490; pfam04357
318586007941	Family of unknown function (DUF490); Region: DUF490; pfam04357
318586007942	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
318586007943	Surface antigen; Region: Bac_surface_Ag; pfam01103
318586007944	Glucokinase; Region: Glucokinase; cl17310
318586007945	glucokinase, proteobacterial type; Region: glk; TIGR00749
318586007946	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
318586007947	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
318586007948	homotetramer interface [polypeptide binding]; other site
318586007949	ligand binding site [chemical binding]; other site
318586007950	catalytic site [active]
318586007951	NAD binding site [chemical binding]; other site
318586007952	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
318586007953	nucleotide binding site/active site [active]
318586007954	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
318586007955	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
318586007956	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586007957	substrate binding site [chemical binding]; other site
318586007958	oxyanion hole (OAH) forming residues; other site
318586007959	trimer interface [polypeptide binding]; other site
318586007960	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
318586007961	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
318586007962	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
318586007963	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
318586007964	active site
318586007965	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
318586007966	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
318586007967	Protein of unknown function (DUF330); Region: DUF330; pfam03886
318586007968	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
318586007969	mce related protein; Region: MCE; pfam02470
318586007970	mce related protein; Region: MCE; pfam02470
318586007971	mce related protein; Region: MCE; pfam02470
318586007972	Paraquat-inducible protein A; Region: PqiA; pfam04403
318586007973	Paraquat-inducible protein A; Region: PqiA; pfam04403
318586007974	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
318586007975	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
318586007976	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
318586007977	ligand binding site [chemical binding]; other site
318586007978	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
318586007979	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
318586007980	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
318586007981	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
318586007982	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
318586007983	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
318586007984	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
318586007985	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
318586007986	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
318586007987	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
318586007988	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
318586007989	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586007990	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586007991	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
318586007992	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
318586007993	active site clefts [active]
318586007994	zinc binding site [ion binding]; other site
318586007995	dimer interface [polypeptide binding]; other site
318586007996	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
318586007997	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
318586007998	interface (dimer of trimers) [polypeptide binding]; other site
318586007999	Substrate-binding/catalytic site; other site
318586008000	Zn-binding sites [ion binding]; other site
318586008001	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
318586008002	NlpC/P60 family; Region: NLPC_P60; cl17555
318586008003	Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188
318586008004	active site
318586008005	ligand binding site [chemical binding]; other site
318586008006	homodimer interface [polypeptide binding]; other site
318586008007	NAD(P) binding site [chemical binding]; other site
318586008008	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
318586008009	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
318586008010	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
318586008011	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
318586008012	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
318586008013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586008014	ATP binding site [chemical binding]; other site
318586008015	Mg2+ binding site [ion binding]; other site
318586008016	G-X-G motif; other site
318586008017	DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119
318586008018	ATP binding site [chemical binding]; other site
318586008019	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
318586008020	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
318586008021	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
318586008022	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
318586008023	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
318586008024	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
318586008025	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
318586008026	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
318586008027	lipoprotein signal peptidase; Provisional; Region: PRK14787
318586008028	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
318586008029	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
318586008030	purine monophosphate binding site [chemical binding]; other site
318586008031	dimer interface [polypeptide binding]; other site
318586008032	putative catalytic residues [active]
318586008033	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
318586008034	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
318586008035	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
318586008036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586008037	S-adenosylmethionine binding site [chemical binding]; other site
318586008038	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586008039	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586008040	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
318586008041	selenophosphate synthetase; Provisional; Region: PRK00943
318586008042	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
318586008043	dimerization interface [polypeptide binding]; other site
318586008044	putative ATP binding site [chemical binding]; other site
318586008045	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586008046	CoenzymeA binding site [chemical binding]; other site
318586008047	subunit interaction site [polypeptide binding]; other site
318586008048	PHB binding site; other site
318586008049	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
318586008050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
318586008051	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
318586008052	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
318586008053	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
318586008054	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
318586008055	Peptidase family M23; Region: Peptidase_M23; pfam01551
318586008056	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
318586008057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586008058	S-adenosylmethionine binding site [chemical binding]; other site
318586008059	stationary phase survival protein SurE; Provisional; Region: PRK13931
318586008060	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586008061	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
318586008062	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
318586008063	Protein of unknown function, DUF482; Region: DUF482; pfam04339
318586008064	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
318586008065	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
318586008066	active site
318586008067	catalytic site [active]
318586008068	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
318586008069	homotrimer interaction site [polypeptide binding]; other site
318586008070	putative active site [active]
318586008071	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
318586008072	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
318586008073	Walker A/P-loop; other site
318586008074	ATP binding site [chemical binding]; other site
318586008075	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
318586008076	Walker B; other site
318586008077	D-loop; other site
318586008078	H-loop/switch region; other site
318586008079	LrgA family; Region: LrgA; pfam03788
318586008080	LrgB-like family; Region: LrgB; pfam04172
318586008081	elongation factor P; Validated; Region: PRK00529
318586008082	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
318586008083	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
318586008084	RNA binding site [nucleotide binding]; other site
318586008085	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
318586008086	RNA binding site [nucleotide binding]; other site
318586008087	Predicted acetyltransferase [General function prediction only]; Region: COG2388
318586008088	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
318586008089	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
318586008090	putative ligand binding site [chemical binding]; other site
318586008091	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
318586008092	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586008093	Walker A/P-loop; other site
318586008094	ATP binding site [chemical binding]; other site
318586008095	Q-loop/lid; other site
318586008096	ABC transporter signature motif; other site
318586008097	Walker B; other site
318586008098	D-loop; other site
318586008099	H-loop/switch region; other site
318586008100	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586008101	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586008102	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586008103	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586008104	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586008105	TM-ABC transporter signature motif; other site
318586008106	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
318586008107	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
318586008108	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
318586008109	active site
318586008110	intersubunit interface [polypeptide binding]; other site
318586008111	catalytic residue [active]
318586008112	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
318586008113	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
318586008114	active site
318586008115	catalytic residues [active]
318586008116	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586008117	DNA-binding site [nucleotide binding]; DNA binding site
318586008118	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586008119	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
318586008120	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
318586008121	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
318586008122	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
318586008123	classical (c) SDRs; Region: SDR_c; cd05233
318586008124	NAD(P) binding site [chemical binding]; other site
318586008125	active site
318586008126	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
318586008127	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586008128	NAD binding site [chemical binding]; other site
318586008129	catalytic residues [active]
318586008130	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
318586008131	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
318586008132	dimer interface [polypeptide binding]; other site
318586008133	decamer (pentamer of dimers) interface [polypeptide binding]; other site
318586008134	catalytic triad [active]
318586008135	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
318586008136	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
318586008137	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
318586008138	RNase E interface [polypeptide binding]; other site
318586008139	trimer interface [polypeptide binding]; other site
318586008140	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
318586008141	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
318586008142	RNase E interface [polypeptide binding]; other site
318586008143	trimer interface [polypeptide binding]; other site
318586008144	active site
318586008145	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
318586008146	putative nucleic acid binding region [nucleotide binding]; other site
318586008147	G-X-X-G motif; other site
318586008148	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
318586008149	RNA binding site [nucleotide binding]; other site
318586008150	domain interface; other site
318586008151	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
318586008152	16S/18S rRNA binding site [nucleotide binding]; other site
318586008153	S13e-L30e interaction site [polypeptide binding]; other site
318586008154	25S rRNA binding site [nucleotide binding]; other site
318586008155	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
318586008156	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
318586008157	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586008158	catalytic residue [active]
318586008159	Gram-negative porin; Region: Porin_4; pfam13609
318586008160	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
318586008161	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
318586008162	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
318586008163	HIGH motif; other site
318586008164	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
318586008165	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586008166	active site
318586008167	KMSKS motif; other site
318586008168	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
318586008169	tRNA binding surface [nucleotide binding]; other site
318586008170	Lipopolysaccharide-assembly; Region: LptE; pfam04390
318586008171	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
318586008172	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
318586008173	catalytic tetrad [active]
318586008174	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
318586008175	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
318586008176	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
318586008177	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586008178	putative C-terminal domain interface [polypeptide binding]; other site
318586008179	putative GSH binding site (G-site) [chemical binding]; other site
318586008180	putative dimer interface [polypeptide binding]; other site
318586008181	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586008182	dimer interface [polypeptide binding]; other site
318586008183	N-terminal domain interface [polypeptide binding]; other site
318586008184	substrate binding pocket (H-site) [chemical binding]; other site
318586008185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586008186	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586008187	putative substrate translocation pore; other site
318586008188	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
318586008189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586008190	putative substrate translocation pore; other site
318586008191	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586008192	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586008193	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
318586008194	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
318586008195	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
318586008196	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
318586008197	conserved hypothetical protein; Region: TIGR02231
318586008198	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
318586008199	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
318586008200	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
318586008201	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
318586008202	PAS fold; Region: PAS_7; pfam12860
318586008203	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586008204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586008205	ATP binding site [chemical binding]; other site
318586008206	Mg2+ binding site [ion binding]; other site
318586008207	G-X-G motif; other site
318586008208	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
318586008209	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
318586008210	Cu(I) binding site [ion binding]; other site
318586008211	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
318586008212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586008213	active site
318586008214	phosphorylation site [posttranslational modification]
318586008215	intermolecular recognition site; other site
318586008216	dimerization interface [polypeptide binding]; other site
318586008217	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
318586008218	H-NS histone family; Region: Histone_HNS; pfam00816
318586008219	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
318586008220	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
318586008221	Preprotein translocase subunit SecB; Region: SecB; pfam02556
318586008222	SecA binding site; other site
318586008223	Preprotein binding site; other site
318586008224	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
318586008225	Tim44-like domain; Region: Tim44; pfam04280
318586008226	Smr domain; Region: Smr; pfam01713
318586008227	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
318586008228	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
318586008229	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
318586008230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
318586008231	Walker A motif; other site
318586008232	ATP binding site [chemical binding]; other site
318586008233	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
318586008234	Walker B motif; other site
318586008235	arginine finger; other site
318586008236	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
318586008237	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
318586008238	active site
318586008239	HslU subunit interaction site [polypeptide binding]; other site
318586008240	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
318586008241	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
318586008242	catalytic residues [active]
318586008243	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
318586008244	Part of AAA domain; Region: AAA_19; pfam13245
318586008245	Family description; Region: UvrD_C_2; pfam13538
318586008246	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
318586008247	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
318586008248	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
318586008249	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
318586008250	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
318586008251	Substrate binding site; other site
318586008252	metal-binding site
318586008253	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
318586008254	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
318586008255	Phosphotransferase enzyme family; Region: APH; pfam01636
318586008256	dihydrodipicolinate reductase; Provisional; Region: PRK00048
318586008257	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
318586008258	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
318586008259	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
318586008260	Predicted periplasmic protein [Function unknown]; Region: COG3698
318586008261	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
318586008262	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
318586008263	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
318586008264	RNA binding site [nucleotide binding]; other site
318586008265	active site
318586008266	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
318586008267	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
318586008268	tetramer interface [polypeptide binding]; other site
318586008269	active site
318586008270	Mg2+/Mn2+ binding site [ion binding]; other site
318586008271	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586008272	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
318586008273	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
318586008274	active site
318586008275	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
318586008276	Uncharacterized conserved protein [Function unknown]; Region: COG3791
318586008277	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
318586008278	GAF domain; Region: GAF_2; pfam13185
318586008279	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586008280	extended (e) SDRs; Region: SDR_e; cd08946
318586008281	NAD(P) binding site [chemical binding]; other site
318586008282	active site
318586008283	substrate binding site [chemical binding]; other site
318586008284	Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537
318586008285	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
318586008286	substrate binding site; other site
318586008287	Manganese binding site; other site
318586008288	dimer interface; other site
318586008289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586008290	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586008291	NAD(P) binding site [chemical binding]; other site
318586008292	active site
318586008293	Predicted transcriptional regulator [Transcription]; Region: COG1959
318586008294	Transcriptional regulator; Region: Rrf2; pfam02082
318586008295	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
318586008296	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
318586008297	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
318586008298	shikimate binding site; other site
318586008299	NAD(P) binding site [chemical binding]; other site
318586008300	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
318586008301	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
318586008302	CoA-binding site [chemical binding]; other site
318586008303	ATP-binding [chemical binding]; other site
318586008304	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
318586008305	active site
318586008306	catalytic site [active]
318586008307	substrate binding site [chemical binding]; other site
318586008308	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
318586008309	Uncharacterized conserved protein [Function unknown]; Region: COG3791
318586008310	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
318586008311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
318586008312	Histidine kinase; Region: HisKA_2; pfam07568
318586008313	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
318586008314	RNA polymerase sigma factor; Provisional; Region: PRK12546
318586008315	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586008316	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
318586008317	two-component response regulator; Provisional; Region: PRK09191
318586008318	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
318586008319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586008320	active site
318586008321	phosphorylation site [posttranslational modification]
318586008322	intermolecular recognition site; other site
318586008323	dimerization interface [polypeptide binding]; other site
318586008324	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
318586008325	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
318586008326	FMN binding site [chemical binding]; other site
318586008327	substrate binding site [chemical binding]; other site
318586008328	putative catalytic residue [active]
318586008329	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586008330	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586008331	active site
318586008332	catalytic tetrad [active]
318586008333	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
318586008334	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
318586008335	G1 box; other site
318586008336	putative GEF interaction site [polypeptide binding]; other site
318586008337	GTP/Mg2+ binding site [chemical binding]; other site
318586008338	Switch I region; other site
318586008339	G2 box; other site
318586008340	G3 box; other site
318586008341	Switch II region; other site
318586008342	G4 box; other site
318586008343	G5 box; other site
318586008344	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
318586008345	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
318586008346	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
318586008347	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
318586008348	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
318586008349	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
318586008350	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
318586008351	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
318586008352	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
318586008353	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
318586008354	molybdopterin cofactor binding site; other site
318586008355	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
318586008356	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
318586008357	molybdopterin cofactor binding site; other site
318586008358	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
318586008359	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
318586008360	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
318586008361	FAD binding pocket [chemical binding]; other site
318586008362	FAD binding motif [chemical binding]; other site
318586008363	phosphate binding motif [ion binding]; other site
318586008364	beta-alpha-beta structure motif; other site
318586008365	NAD binding pocket [chemical binding]; other site
318586008366	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586008367	catalytic loop [active]
318586008368	iron binding site [ion binding]; other site
318586008369	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
318586008370	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
318586008371	[2Fe-2S] cluster binding site [ion binding]; other site
318586008372	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
318586008373	putative alpha subunit interface [polypeptide binding]; other site
318586008374	putative active site [active]
318586008375	putative substrate binding site [chemical binding]; other site
318586008376	Fe binding site [ion binding]; other site
318586008377	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
318586008378	DnaA N-terminal domain; Region: DnaA_N; pfam11638
318586008379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586008380	Walker A motif; other site
318586008381	ATP binding site [chemical binding]; other site
318586008382	Walker B motif; other site
318586008383	arginine finger; other site
318586008384	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
318586008385	DnaA box-binding interface [nucleotide binding]; other site
318586008386	DNA polymerase III subunit beta; Validated; Region: PRK05643
318586008387	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
318586008388	putative DNA binding surface [nucleotide binding]; other site
318586008389	dimer interface [polypeptide binding]; other site
318586008390	beta-clamp/clamp loader binding surface; other site
318586008391	beta-clamp/translesion DNA polymerase binding surface; other site
318586008392	recombination protein F; Reviewed; Region: recF; PRK00064
318586008393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586008394	Walker A/P-loop; other site
318586008395	ATP binding site [chemical binding]; other site
318586008396	Q-loop/lid; other site
318586008397	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586008398	ABC transporter signature motif; other site
318586008399	Walker B; other site
318586008400	D-loop; other site
318586008401	H-loop/switch region; other site
318586008402	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
318586008403	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586008404	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
318586008405	active site
318586008406	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
318586008407	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
318586008408	Recombination protein O N terminal; Region: RecO_N; pfam11967
318586008409	Recombination protein O C terminal; Region: RecO_C; pfam02565
318586008410	META domain; Region: META; pfam03724
318586008411	META domain; Region: META; pfam03724
318586008412	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586008413	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586008414	active site
318586008415	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586008416	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
318586008417	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
318586008418	metal binding site [ion binding]; metal-binding site
318586008419	dimer interface [polypeptide binding]; other site
318586008420	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
318586008421	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
318586008422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586008423	Coenzyme A binding pocket [chemical binding]; other site
318586008424	glutamate--cysteine ligase; Region: PLN02611
318586008425	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
318586008426	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586008427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586008428	WHG domain; Region: WHG; pfam13305
318586008429	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
318586008430	regulatory protein interface [polypeptide binding]; other site
318586008431	active site
318586008432	regulatory phosphorylation site [posttranslational modification]; other site
318586008433	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
318586008434	active pocket/dimerization site; other site
318586008435	active site
318586008436	phosphorylation site [posttranslational modification]
318586008437	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
318586008438	AAA domain; Region: AAA_18; pfam13238
318586008439	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
318586008440	Hpr binding site; other site
318586008441	active site
318586008442	homohexamer subunit interaction site [polypeptide binding]; other site
318586008443	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
318586008444	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
318586008445	active site
318586008446	substrate-binding site [chemical binding]; other site
318586008447	metal-binding site [ion binding]
318586008448	ATP binding site [chemical binding]; other site
318586008449	ribonuclease R; Region: RNase_R; TIGR02063
318586008450	RNB domain; Region: RNB; pfam00773
318586008451	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
318586008452	RNA binding site [nucleotide binding]; other site
318586008453	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
318586008454	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
318586008455	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
318586008456	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586008457	catalytic loop [active]
318586008458	iron binding site [ion binding]; other site
318586008459	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
318586008460	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
318586008461	[4Fe-4S] binding site [ion binding]; other site
318586008462	molybdopterin cofactor binding site; other site
318586008463	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
318586008464	molybdopterin cofactor binding site; other site
318586008465	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
318586008466	putative dimer interface [polypeptide binding]; other site
318586008467	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
318586008468	SLBB domain; Region: SLBB; pfam10531
318586008469	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
318586008470	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
318586008471	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
318586008472	putative dimer interface [polypeptide binding]; other site
318586008473	[2Fe-2S] cluster binding site [ion binding]; other site
318586008474	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586008475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586008476	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586008477	dimerization interface [polypeptide binding]; other site
318586008478	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
318586008479	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
318586008480	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
318586008481	ATP binding site [chemical binding]; other site
318586008482	active site
318586008483	substrate binding site [chemical binding]; other site
318586008484	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
318586008485	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
318586008486	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
318586008487	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586008488	CoenzymeA binding site [chemical binding]; other site
318586008489	subunit interaction site [polypeptide binding]; other site
318586008490	PHB binding site; other site
318586008491	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
318586008492	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586008493	CoenzymeA binding site [chemical binding]; other site
318586008494	subunit interaction site [polypeptide binding]; other site
318586008495	PHB binding site; other site
318586008496	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
318586008497	DNA binding residues [nucleotide binding]
318586008498	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
318586008499	putative dimer interface [polypeptide binding]; other site
318586008500	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
318586008501	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
318586008502	DNA binding residues [nucleotide binding]
318586008503	putative dimer interface [polypeptide binding]; other site
318586008504	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
318586008505	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
318586008506	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586008507	active site
318586008508	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
318586008509	maleylacetoacetate isomerase; Region: maiA; TIGR01262
318586008510	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
318586008511	putative C-terminal domain interface [polypeptide binding]; other site
318586008512	putative GSH binding site (G-site) [chemical binding]; other site
318586008513	putative dimer interface [polypeptide binding]; other site
318586008514	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586008515	N-terminal domain interface [polypeptide binding]; other site
318586008516	dimer interface [polypeptide binding]; other site
318586008517	substrate binding pocket (H-site) [chemical binding]; other site
318586008518	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
318586008519	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586008520	dimer interface [polypeptide binding]; other site
318586008521	active site
318586008522	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
318586008523	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586008524	substrate binding site [chemical binding]; other site
318586008525	oxyanion hole (OAH) forming residues; other site
318586008526	trimer interface [polypeptide binding]; other site
318586008527	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586008528	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586008529	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586008530	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586008531	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
318586008532	substrate binding site [chemical binding]; other site
318586008533	ATP binding site [chemical binding]; other site
318586008534	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
318586008535	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
318586008536	minor groove reading motif; other site
318586008537	helix-hairpin-helix signature motif; other site
318586008538	substrate binding pocket [chemical binding]; other site
318586008539	active site
318586008540	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
318586008541	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
318586008542	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
318586008543	DNA binding site [nucleotide binding]
318586008544	active site
318586008545	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
318586008546	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586008547	ligand binding site [chemical binding]; other site
318586008548	F0F1 ATP synthase subunit B; Provisional; Region: PRK13455
318586008549	F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454
318586008550	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
318586008551	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
318586008552	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
318586008553	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
318586008554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586008555	dimerization interface [polypeptide binding]; other site
318586008556	putative DNA binding site [nucleotide binding]; other site
318586008557	putative Zn2+ binding site [ion binding]; other site
318586008558	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
318586008559	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
318586008560	active site
318586008561	metal binding site [ion binding]; metal-binding site
318586008562	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
318586008563	Protein of unknown function (DUF952); Region: DUF952; pfam06108
318586008564	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
318586008565	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
318586008566	quinone interaction residues [chemical binding]; other site
318586008567	active site
318586008568	catalytic residues [active]
318586008569	FMN binding site [chemical binding]; other site
318586008570	substrate binding site [chemical binding]; other site
318586008571	serine acetyltransferase; Provisional; Region: cysE; PRK11132
318586008572	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
318586008573	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
318586008574	trimer interface [polypeptide binding]; other site
318586008575	active site
318586008576	substrate binding site [chemical binding]; other site
318586008577	CoA binding site [chemical binding]; other site
318586008578	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
318586008579	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
318586008580	Putative phage tail protein; Region: Phage-tail_3; pfam13550
318586008581	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
318586008582	NlpC/P60 family; Region: NLPC_P60; cl17555
318586008583	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
318586008584	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
318586008585	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
318586008586	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
318586008587	Phage-related minor tail protein [Function unknown]; Region: COG5281
318586008588	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550
318586008589	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
318586008590	Phage major tail protein 2; Region: Phage_tail_2; cl11463
318586008591	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
318586008592	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
318586008593	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
318586008594	Phage capsid family; Region: Phage_capsid; pfam05065
318586008595	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
318586008596	Phage-related protein [Function unknown]; Region: COG4695
318586008597	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
318586008598	Uncharacterized conserved protein [Function unknown]; Region: COG5323
318586008599	Terminase-like family; Region: Terminase_6; pfam03237
318586008600	YceG-like family; Region: YceG; pfam02618
318586008601	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
318586008602	dimerization interface [polypeptide binding]; other site
318586008603	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
318586008604	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
318586008605	dimer interface [polypeptide binding]; other site
318586008606	active site
318586008607	enoyl-CoA hydratase; Provisional; Region: PRK05862
318586008608	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586008609	substrate binding site [chemical binding]; other site
318586008610	oxyanion hole (OAH) forming residues; other site
318586008611	trimer interface [polypeptide binding]; other site
318586008612	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586008613	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586008614	active site
318586008615	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
318586008616	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586008617	dimer interface [polypeptide binding]; other site
318586008618	active site
318586008619	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
318586008620	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586008621	NAD(P) binding site [chemical binding]; other site
318586008622	active site
318586008623	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
318586008624	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973
318586008625	active site
318586008626	acyl-activating enzyme (AAE) consensus motif; other site
318586008627	putative CoA binding site [chemical binding]; other site
318586008628	AMP binding site [chemical binding]; other site
318586008629	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
318586008630	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586008631	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586008632	HTH DNA binding domain; Region: HTH_13; pfam11972
318586008633	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
318586008634	ParB-like nuclease domain; Region: ParBc; pfam02195
318586008635	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
318586008636	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586008637	P-loop; other site
318586008638	Magnesium ion binding site [ion binding]; other site
318586008639	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586008640	Magnesium ion binding site [ion binding]; other site
318586008641	DnaA N-terminal domain; Region: DnaA_N; pfam11638
318586008642	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
318586008643	biotin synthase; Region: bioB; TIGR00433
318586008644	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586008645	FeS/SAM binding site; other site
318586008646	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
318586008647	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
318586008648	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586008649	catalytic residue [active]
318586008650	AAA domain; Region: AAA_26; pfam13500
318586008651	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
318586008652	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586008653	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
318586008654	inhibitor-cofactor binding pocket; inhibition site
318586008655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586008656	catalytic residue [active]
318586008657	Protein of unknown function (DUF452); Region: DUF452; cl01062
318586008658	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
318586008659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586008660	S-adenosylmethionine binding site [chemical binding]; other site
318586008661	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586008662	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586008663	DNA-binding site [nucleotide binding]; DNA binding site
318586008664	FCD domain; Region: FCD; pfam07729
318586008665	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
318586008666	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
318586008667	iron-sulfur cluster-binding protein; Region: TIGR00273
318586008668	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
318586008669	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
318586008670	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
318586008671	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
318586008672	Cysteine-rich domain; Region: CCG; pfam02754
318586008673	Cysteine-rich domain; Region: CCG; pfam02754
318586008674	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
318586008675	L-lactate permease; Region: Lactate_perm; cl00701
318586008676	D-lactate dehydrogenase; Provisional; Region: PRK11183
318586008677	FAD binding domain; Region: FAD_binding_4; pfam01565
318586008678	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
318586008679	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586008680	DNA-binding site [nucleotide binding]; DNA binding site
318586008681	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
318586008682	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
318586008683	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
318586008684	fructuronate transporter; Provisional; Region: PRK10034; cl15264
318586008685	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
318586008686	AAA domain; Region: AAA_33; pfam13671
318586008687	ATP-binding site [chemical binding]; other site
318586008688	Gluconate-6-phosphate binding site [chemical binding]; other site
318586008689	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
318586008690	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
318586008691	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
318586008692	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
318586008693	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
318586008694	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
318586008695	putative acyl-acceptor binding pocket; other site
318586008696	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
318586008697	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
318586008698	Walker A/P-loop; other site
318586008699	ATP binding site [chemical binding]; other site
318586008700	Q-loop/lid; other site
318586008701	ABC transporter signature motif; other site
318586008702	Walker B; other site
318586008703	D-loop; other site
318586008704	H-loop/switch region; other site
318586008705	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
318586008706	FtsX-like permease family; Region: FtsX; pfam02687
318586008707	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586008708	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586008709	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586008710	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586008711	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586008712	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586008713	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586008714	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586008715	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
318586008716	Protein export membrane protein; Region: SecD_SecF; cl14618
318586008717	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
318586008718	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
318586008719	ThiC-associated domain; Region: ThiC-associated; pfam13667
318586008720	ThiC family; Region: ThiC; pfam01964
318586008721	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
318586008722	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
318586008723	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586008724	putative substrate binding site [chemical binding]; other site
318586008725	putative ATP binding site [chemical binding]; other site
318586008726	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
318586008727	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
318586008728	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
318586008729	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
318586008730	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
318586008731	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586008732	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
318586008733	conserved cys residue [active]
318586008734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586008735	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
318586008736	Domain of unknown function DUF20; Region: UPF0118; pfam01594
318586008737	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
318586008738	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
318586008739	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
318586008740	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
318586008741	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
318586008742	dimer interface [polypeptide binding]; other site
318586008743	active site
318586008744	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586008745	catalytic residues [active]
318586008746	substrate binding site [chemical binding]; other site
318586008747	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586008748	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586008749	Transcriptional regulator; Region: Rrf2; cl17282
318586008750	Rrf2 family protein; Region: rrf2_super; TIGR00738
318586008751	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
318586008752	HD domain; Region: HD_3; pfam13023
318586008753	HD domain; Region: HD_3; pfam13023
318586008754	isocitrate dehydrogenase; Validated; Region: PRK08299
318586008755	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
318586008756	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
318586008757	putative active site [active]
318586008758	catalytic triad [active]
318586008759	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
318586008760	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586008761	dimer interface [polypeptide binding]; other site
318586008762	phosphorylation site [posttranslational modification]
318586008763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586008764	ATP binding site [chemical binding]; other site
318586008765	Mg2+ binding site [ion binding]; other site
318586008766	G-X-G motif; other site
318586008767	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586008768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586008769	active site
318586008770	phosphorylation site [posttranslational modification]
318586008771	intermolecular recognition site; other site
318586008772	dimerization interface [polypeptide binding]; other site
318586008773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586008774	Walker A motif; other site
318586008775	ATP binding site [chemical binding]; other site
318586008776	Walker B motif; other site
318586008777	arginine finger; other site
318586008778	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
318586008779	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
318586008780	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
318586008781	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
318586008782	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
318586008783	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
318586008784	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
318586008785	enoyl-CoA hydratase; Validated; Region: PRK08139
318586008786	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586008787	substrate binding site [chemical binding]; other site
318586008788	oxyanion hole (OAH) forming residues; other site
318586008789	trimer interface [polypeptide binding]; other site
318586008790	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586008791	CoenzymeA binding site [chemical binding]; other site
318586008792	subunit interaction site [polypeptide binding]; other site
318586008793	PHB binding site; other site
318586008794	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
318586008795	23S rRNA interface [nucleotide binding]; other site
318586008796	L3 interface [polypeptide binding]; other site
318586008797	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
318586008798	fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290
318586008799	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
318586008800	ATP-binding site [chemical binding]; other site
318586008801	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586008802	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
318586008803	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586008804	Secretin and TonB N terminus short domain; Region: STN; smart00965
318586008805	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586008806	N-terminal plug; other site
318586008807	ligand-binding site [chemical binding]; other site
318586008808	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
318586008809	FecR protein; Region: FecR; pfam04773
318586008810	RNA polymerase sigma factor; Reviewed; Region: PRK12527
318586008811	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586008812	DNA binding residues [nucleotide binding]
318586008813	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586008814	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
318586008815	intersubunit interface [polypeptide binding]; other site
318586008816	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586008817	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586008818	ABC-ATPase subunit  interface; other site
318586008819	dimer interface [polypeptide binding]; other site
318586008820	putative PBP binding regions; other site
318586008821	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586008822	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586008823	Walker A/P-loop; other site
318586008824	ATP binding site [chemical binding]; other site
318586008825	Q-loop/lid; other site
318586008826	ABC transporter signature motif; other site
318586008827	Walker B; other site
318586008828	D-loop; other site
318586008829	H-loop/switch region; other site
318586008830	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
318586008831	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
318586008832	Methyltransferase domain; Region: Methyltransf_31; pfam13847
318586008833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586008834	S-adenosylmethionine binding site [chemical binding]; other site
318586008835	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
318586008836	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
318586008837	active site
318586008838	metal binding site [ion binding]; metal-binding site
318586008839	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
318586008840	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586008841	FeS/SAM binding site; other site
318586008842	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
318586008843	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
318586008844	Class III ribonucleotide reductase; Region: RNR_III; cd01675
318586008845	effector binding site; other site
318586008846	active site
318586008847	Zn binding site [ion binding]; other site
318586008848	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586008849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586008850	active site
318586008851	phosphorylation site [posttranslational modification]
318586008852	intermolecular recognition site; other site
318586008853	dimerization interface [polypeptide binding]; other site
318586008854	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586008855	DNA binding residues [nucleotide binding]
318586008856	dimerization interface [polypeptide binding]; other site
318586008857	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
318586008858	dimerization interface [polypeptide binding]; other site
318586008859	Histidine kinase; Region: HisKA_3; pfam07730
318586008860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
318586008861	Mg2+ binding site [ion binding]; other site
318586008862	G-X-G motif; other site
318586008863	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
318586008864	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
318586008865	Trp docking motif [polypeptide binding]; other site
318586008866	dimer interface [polypeptide binding]; other site
318586008867	active site
318586008868	small subunit binding site [polypeptide binding]; other site
318586008869	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
318586008870	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586008871	substrate binding pocket [chemical binding]; other site
318586008872	membrane-bound complex binding site; other site
318586008873	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
318586008874	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
318586008875	MoxR-like ATPases [General function prediction only]; Region: COG0714
318586008876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586008877	Walker A motif; other site
318586008878	ATP binding site [chemical binding]; other site
318586008879	Walker B motif; other site
318586008880	arginine finger; other site
318586008881	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
318586008882	metal ion-dependent adhesion site (MIDAS); other site
318586008883	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
318586008884	metal ion-dependent adhesion site (MIDAS); other site
318586008885	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
318586008886	putative hydrophobic ligand binding site [chemical binding]; other site
318586008887	protein interface [polypeptide binding]; other site
318586008888	gate; other site
318586008889	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
318586008890	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586008891	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586008892	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586008893	N-terminal plug; other site
318586008894	ligand-binding site [chemical binding]; other site
318586008895	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
318586008896	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
318586008897	acyl-activating enzyme (AAE) consensus motif; other site
318586008898	active site
318586008899	AMP binding site [chemical binding]; other site
318586008900	substrate binding site [chemical binding]; other site
318586008901	Chorismate mutase type II; Region: CM_2; cl00693
318586008902	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586008903	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
318586008904	intersubunit interface [polypeptide binding]; other site
318586008905	FecCD transport family; Region: FecCD; pfam01032
318586008906	dimer interface [polypeptide binding]; other site
318586008907	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586008908	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
318586008909	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586008910	ABC-ATPase subunit  interface; other site
318586008911	dimer interface [polypeptide binding]; other site
318586008912	putative PBP binding regions; other site
318586008913	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586008914	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586008915	Walker A/P-loop; other site
318586008916	ATP binding site [chemical binding]; other site
318586008917	Q-loop/lid; other site
318586008918	ABC transporter signature motif; other site
318586008919	Walker B; other site
318586008920	D-loop; other site
318586008921	H-loop/switch region; other site
318586008922	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
318586008923	Condensation domain; Region: Condensation; pfam00668
318586008924	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
318586008925	Nonribosomal peptide synthase; Region: NRPS; pfam08415
318586008926	Nonribosomal peptide synthase; Region: NRPS; pfam08415
318586008927	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
318586008928	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
318586008929	acyl-activating enzyme (AAE) consensus motif; other site
318586008930	AMP binding site [chemical binding]; other site
318586008931	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
318586008932	Condensation domain; Region: Condensation; pfam00668
318586008933	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
318586008934	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586008935	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586008936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586008937	Walker A/P-loop; other site
318586008938	ATP binding site [chemical binding]; other site
318586008939	Q-loop/lid; other site
318586008940	ABC transporter signature motif; other site
318586008941	Walker B; other site
318586008942	D-loop; other site
318586008943	H-loop/switch region; other site
318586008944	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586008945	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586008946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586008947	Walker A/P-loop; other site
318586008948	ATP binding site [chemical binding]; other site
318586008949	Q-loop/lid; other site
318586008950	ABC transporter signature motif; other site
318586008951	Walker B; other site
318586008952	D-loop; other site
318586008953	H-loop/switch region; other site
318586008954	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619
318586008955	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
318586008956	putative SdhC subunit interface [polypeptide binding]; other site
318586008957	putative proximal heme binding site [chemical binding]; other site
318586008958	putative Iron-sulfur protein interface [polypeptide binding]; other site
318586008959	putative proximal quinone binding site; other site
318586008960	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
318586008961	Iron-sulfur protein interface; other site
318586008962	proximal quinone binding site [chemical binding]; other site
318586008963	SdhD (CybS) interface [polypeptide binding]; other site
318586008964	proximal heme binding site [chemical binding]; other site
318586008965	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
318586008966	Transcriptional regulator; Region: Rrf2; cl17282
318586008967	Rrf2 family protein; Region: rrf2_super; TIGR00738
318586008968	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
318586008969	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
318586008970	Hemerythrin-like domain; Region: Hr-like; cd12108
318586008971	Fe binding site [ion binding]; other site
318586008972	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
318586008973	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
318586008974	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
318586008975	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
318586008976	Subunit I/III interface [polypeptide binding]; other site
318586008977	D-pathway; other site
318586008978	Subunit I/VIIc interface [polypeptide binding]; other site
318586008979	Subunit I/IV interface [polypeptide binding]; other site
318586008980	Subunit I/II interface [polypeptide binding]; other site
318586008981	Low-spin heme (heme a) binding site [chemical binding]; other site
318586008982	Subunit I/VIIa interface [polypeptide binding]; other site
318586008983	Subunit I/VIa interface [polypeptide binding]; other site
318586008984	Dimer interface; other site
318586008985	Putative water exit pathway; other site
318586008986	Binuclear center (heme a3/CuB) [ion binding]; other site
318586008987	K-pathway; other site
318586008988	Subunit I/Vb interface [polypeptide binding]; other site
318586008989	Putative proton exit pathway; other site
318586008990	Subunit I/VIb interface; other site
318586008991	Subunit I/VIc interface [polypeptide binding]; other site
318586008992	Electron transfer pathway; other site
318586008993	Subunit I/VIIIb interface [polypeptide binding]; other site
318586008994	Subunit I/VIIb interface [polypeptide binding]; other site
318586008995	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586008996	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586008997	N-terminal plug; other site
318586008998	ligand-binding site [chemical binding]; other site
318586008999	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
318586009000	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586009001	ABC-ATPase subunit  interface; other site
318586009002	dimer interface [polypeptide binding]; other site
318586009003	putative PBP binding regions; other site
318586009004	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586009005	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586009006	Walker A/P-loop; other site
318586009007	ATP binding site [chemical binding]; other site
318586009008	Q-loop/lid; other site
318586009009	ABC transporter signature motif; other site
318586009010	Walker B; other site
318586009011	D-loop; other site
318586009012	H-loop/switch region; other site
318586009013	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
318586009014	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
318586009015	putative ligand binding residues [chemical binding]; other site
318586009016	Coenzyme A transferase; Region: CoA_trans; cl17247
318586009017	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
318586009018	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
318586009019	Sulfate transporter family; Region: Sulfate_transp; pfam00916
318586009020	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
318586009021	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
318586009022	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
318586009023	putative ion selectivity filter; other site
318586009024	putative pore gating glutamate residue; other site
318586009025	putative H+/Cl- coupling transport residue; other site
318586009026	BCCT family transporter; Region: BCCT; pfam02028
318586009027	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
318586009028	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586009029	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586009030	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
318586009031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586009032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586009033	putative substrate translocation pore; other site
318586009034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586009035	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586009036	putative substrate translocation pore; other site
318586009037	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
318586009038	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
318586009039	NAD(P) binding site [chemical binding]; other site
318586009040	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586009041	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586009042	putative DNA binding site [nucleotide binding]; other site
318586009043	putative Zn2+ binding site [ion binding]; other site
318586009044	hypothetical protein; Provisional; Region: PRK06184
318586009045	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586009046	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
318586009047	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
318586009048	TPP-binding site [chemical binding]; other site
318586009049	tetramer interface [polypeptide binding]; other site
318586009050	heterodimer interface [polypeptide binding]; other site
318586009051	phosphorylation loop region [posttranslational modification]
318586009052	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
318586009053	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
318586009054	alpha subunit interface [polypeptide binding]; other site
318586009055	TPP binding site [chemical binding]; other site
318586009056	heterodimer interface [polypeptide binding]; other site
318586009057	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586009058	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586009059	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
318586009060	non-specific DNA interactions [nucleotide binding]; other site
318586009061	DNA binding site [nucleotide binding]
318586009062	sequence specific DNA binding site [nucleotide binding]; other site
318586009063	putative cAMP binding site [chemical binding]; other site
318586009064	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586009065	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
318586009066	homotrimer interaction site [polypeptide binding]; other site
318586009067	putative active site [active]
318586009068	aminotransferase; Provisional; Region: PRK06105
318586009069	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586009070	inhibitor-cofactor binding pocket; inhibition site
318586009071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586009072	catalytic residue [active]
318586009073	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
318586009074	Amidase; Region: Amidase; cl11426
318586009075	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586009076	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
318586009077	ligand binding site [chemical binding]; other site
318586009078	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586009079	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586009080	Walker A/P-loop; other site
318586009081	ATP binding site [chemical binding]; other site
318586009082	Q-loop/lid; other site
318586009083	ABC transporter signature motif; other site
318586009084	Walker B; other site
318586009085	D-loop; other site
318586009086	H-loop/switch region; other site
318586009087	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586009088	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586009089	Walker A/P-loop; other site
318586009090	ATP binding site [chemical binding]; other site
318586009091	Q-loop/lid; other site
318586009092	ABC transporter signature motif; other site
318586009093	Walker B; other site
318586009094	D-loop; other site
318586009095	H-loop/switch region; other site
318586009096	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586009097	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586009098	TM-ABC transporter signature motif; other site
318586009099	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586009100	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586009101	TM-ABC transporter signature motif; other site
318586009102	indole acetimide hydrolase; Validated; Region: PRK07488
318586009103	Amidase; Region: Amidase; pfam01425
318586009104	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586009105	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
318586009106	Autotransporter beta-domain; Region: Autotransporter; pfam03797
318586009107	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615
318586009108	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
318586009109	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
318586009110	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
318586009111	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586009112	EamA-like transporter family; Region: EamA; pfam00892
318586009113	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009114	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586009115	aconitate hydratase; Provisional; Region: acnA; PRK12881
318586009116	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
318586009117	substrate binding site [chemical binding]; other site
318586009118	ligand binding site [chemical binding]; other site
318586009119	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
318586009120	substrate binding site [chemical binding]; other site
318586009121	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586009122	DNA-binding site [nucleotide binding]; DNA binding site
318586009123	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
318586009124	DNA-binding site [nucleotide binding]; DNA binding site
318586009125	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586009126	FCD domain; Region: FCD; pfam07729
318586009127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
318586009128	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
318586009129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
318586009130	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
318586009131	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
318586009132	Putative phage tail protein; Region: Phage-tail_3; pfam13550
318586009133	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
318586009134	C1q domain; Region: C1q; cl17543
318586009135	Transposase IS200 like; Region: Y1_Tnp; pfam01797
318586009136	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
318586009137	Protein of unknown function (DUF3011); Region: DUF3011; pfam11218
318586009138	Autotransporter beta-domain; Region: Autotransporter; smart00869
318586009139	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
318586009140	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
318586009141	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586009142	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586009143	substrate binding pocket [chemical binding]; other site
318586009144	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586009145	membrane-bound complex binding site; other site
318586009146	hinge residues; other site
318586009147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586009148	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586009149	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586009150	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586009151	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
318586009152	active site
318586009153	Int/Topo IB signature motif; other site
318586009154	DNA binding site [nucleotide binding]
318586009155	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
318586009156	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
318586009157	putative active site [active]
318586009158	heme pocket [chemical binding]; other site
318586009159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586009160	dimer interface [polypeptide binding]; other site
318586009161	phosphorylation site [posttranslational modification]
318586009162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586009163	ATP binding site [chemical binding]; other site
318586009164	Mg2+ binding site [ion binding]; other site
318586009165	G-X-G motif; other site
318586009166	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
318586009167	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
318586009168	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
318586009169	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
318586009170	Acylphosphatase; Region: Acylphosphatase; pfam00708
318586009171	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
318586009172	HypF finger; Region: zf-HYPF; pfam07503
318586009173	HypF finger; Region: zf-HYPF; pfam07503
318586009174	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
318586009175	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
318586009176	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
318586009177	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
318586009178	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
318586009179	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
318586009180	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
318586009181	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
318586009182	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
318586009183	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
318586009184	putative substrate-binding site; other site
318586009185	nickel binding site [ion binding]; other site
318586009186	HupF/HypC family; Region: HupF_HypC; pfam01455
318586009187	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
318586009188	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
318586009189	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
318586009190	Rubredoxin; Region: Rubredoxin; pfam00301
318586009191	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
318586009192	iron binding site [ion binding]; other site
318586009193	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
318586009194	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
318586009195	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
318586009196	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
318586009197	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586009198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586009199	active site
318586009200	phosphorylation site [posttranslational modification]
318586009201	intermolecular recognition site; other site
318586009202	dimerization interface [polypeptide binding]; other site
318586009203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586009204	Walker A motif; other site
318586009205	ATP binding site [chemical binding]; other site
318586009206	Walker B motif; other site
318586009207	arginine finger; other site
318586009208	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
318586009209	HupF/HypC family; Region: HupF_HypC; cl00394
318586009210	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
318586009211	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
318586009212	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
318586009213	dimerization interface [polypeptide binding]; other site
318586009214	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
318586009215	ATP binding site [chemical binding]; other site
318586009216	Domain of unknown function DUF21; Region: DUF21; pfam01595
318586009217	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
318586009218	Domain of unknown function DUF21; Region: DUF21; pfam01595
318586009219	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
318586009220	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
318586009221	Transporter associated domain; Region: CorC_HlyC; pfam03471
318586009222	Cupin; Region: Cupin_6; pfam12852
318586009223	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586009224	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586009225	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586009226	short chain dehydrogenase; Provisional; Region: PRK08267
318586009227	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
318586009228	NADP binding site [chemical binding]; other site
318586009229	active site
318586009230	steroid binding site; other site
318586009231	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
318586009232	active site
318586009233	Predicted transcriptional regulator [Transcription]; Region: COG1959
318586009234	Transcriptional regulator; Region: Rrf2; pfam02082
318586009235	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
318586009236	Methyltransferase domain; Region: Methyltransf_12; pfam08242
318586009237	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586009238	active site
318586009239	Int/Topo IB signature motif; other site
318586009240	DNA binding site [nucleotide binding]
318586009241	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586009242	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
318586009243	catalytic residues [active]
318586009244	catalytic nucleophile [active]
318586009245	Recombinase; Region: Recombinase; pfam07508
318586009246	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
318586009247	Ceramidase; Region: Ceramidase; pfam05875
318586009248	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
318586009249	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
318586009250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586009251	motif II; other site
318586009252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586009253	active site
318586009254	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
318586009255	DNA protecting protein DprA; Region: dprA; TIGR00732
318586009256	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586009257	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
318586009258	Chromate transporter; Region: Chromate_transp; pfam02417
318586009259	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
318586009260	active site residue [active]
318586009261	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
318586009262	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
318586009263	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586009264	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
318586009265	arsenical-resistance protein; Region: acr3; TIGR00832
318586009266	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
318586009267	ArsC family; Region: ArsC; pfam03960
318586009268	catalytic residues [active]
318586009269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586009270	dimerization interface [polypeptide binding]; other site
318586009271	putative DNA binding site [nucleotide binding]; other site
318586009272	putative Zn2+ binding site [ion binding]; other site
318586009273	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586009274	DNA-binding site [nucleotide binding]; DNA binding site
318586009275	RNA-binding motif; other site
318586009276	Protein of unknown function (DUF982); Region: DUF982; pfam06169
318586009277	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586009278	DNA-binding site [nucleotide binding]; DNA binding site
318586009279	RNA-binding motif; other site
318586009280	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
318586009281	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
318586009282	putative dimer interface [polypeptide binding]; other site
318586009283	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
318586009284	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
318586009285	putative dimer interface [polypeptide binding]; other site
318586009286	SPW repeat; Region: SPW; pfam03779
318586009287	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
318586009288	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
318586009289	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
318586009290	protein binding site [polypeptide binding]; other site
318586009291	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
318586009292	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
318586009293	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
318586009294	Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096
318586009295	Cupin domain; Region: Cupin_2; pfam07883
318586009296	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
318586009297	Methyltransferase domain; Region: Methyltransf_31; pfam13847
318586009298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586009299	S-adenosylmethionine binding site [chemical binding]; other site
318586009300	H-NS histone family; Region: Histone_HNS; pfam00816
318586009301	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
318586009302	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
318586009303	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
318586009304	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586009305	Coenzyme A binding pocket [chemical binding]; other site
318586009306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586009307	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586009308	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586009309	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
318586009310	Transposase; Region: HTH_Tnp_1; cl17663
318586009311	putative transposase OrfB; Reviewed; Region: PHA02517
318586009312	HTH-like domain; Region: HTH_21; pfam13276
318586009313	Integrase core domain; Region: rve; pfam00665
318586009314	Integrase core domain; Region: rve_3; pfam13683
318586009315	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
318586009316	DNA methylase; Region: N6_N4_Mtase; cl17433
318586009317	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586009318	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
318586009319	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
318586009320	dimer interface [polypeptide binding]; other site
318586009321	ssDNA binding site [nucleotide binding]; other site
318586009322	tetramer (dimer of dimers) interface [polypeptide binding]; other site
318586009323	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586009324	non-specific DNA binding site [nucleotide binding]; other site
318586009325	salt bridge; other site
318586009326	sequence-specific DNA binding site [nucleotide binding]; other site
318586009327	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
318586009328	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
318586009329	EamA-like transporter family; Region: EamA; pfam00892
318586009330	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
318586009331	putative active site [active]
318586009332	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
318586009333	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
318586009334	Helix-turn-helix domain; Region: HTH_17; pfam12728
318586009335	Replication initiator protein A; Region: RPA; pfam10134
318586009336	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
318586009337	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
318586009338	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586009339	cofactor binding site; other site
318586009340	DNA binding site [nucleotide binding]
318586009341	substrate interaction site [chemical binding]; other site
318586009342	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
318586009343	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
318586009344	Protein of unknown function (DUF736); Region: DUF736; pfam05284
318586009345	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586009346	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586009347	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586009348	catalytic residue [active]
318586009349	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
318586009350	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
318586009351	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
318586009352	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
318586009353	Walker A motif; other site
318586009354	ATP binding site [chemical binding]; other site
318586009355	Walker B motif; other site
318586009356	Predicted ATPase [General function prediction only]; Region: COG3911
318586009357	AAA domain; Region: AAA_28; pfam13521
318586009358	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
318586009359	oligomeric interface; other site
318586009360	putative active site [active]
318586009361	homodimer interface [polypeptide binding]; other site
318586009362	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
318586009363	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
318586009364	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
318586009365	Walker A motif; other site
318586009366	ATP binding site [chemical binding]; other site
318586009367	Walker B motif; other site
318586009368	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
318586009369	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
318586009370	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
318586009371	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
318586009372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586009373	Walker A/P-loop; other site
318586009374	ATP binding site [chemical binding]; other site
318586009375	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
318586009376	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
318586009377	conjugal transfer protein TrbL; Provisional; Region: PRK13875
318586009378	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
318586009379	conjugal transfer protein TrbF; Provisional; Region: PRK13872
318586009380	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
318586009381	VirB7 interaction site; other site
318586009382	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
318586009383	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
318586009384	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
318586009385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009386	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
318586009387	dimerization interface [polypeptide binding]; other site
318586009388	substrate binding pocket [chemical binding]; other site
318586009389	Transcriptional regulators [Transcription]; Region: FadR; COG2186
318586009390	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586009391	DNA-binding site [nucleotide binding]; DNA binding site
318586009392	FCD domain; Region: FCD; pfam07729
318586009393	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
318586009394	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
318586009395	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586009396	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
318586009397	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
318586009398	active site
318586009399	NAD binding site [chemical binding]; other site
318586009400	metal binding site [ion binding]; metal-binding site
318586009401	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
318586009402	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586009403	NAD binding site [chemical binding]; other site
318586009404	catalytic residues [active]
318586009405	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
318586009406	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
318586009407	putative NAD(P) binding site [chemical binding]; other site
318586009408	putative substrate binding site [chemical binding]; other site
318586009409	catalytic Zn binding site [ion binding]; other site
318586009410	structural Zn binding site [ion binding]; other site
318586009411	dimer interface [polypeptide binding]; other site
318586009412	enoyl-CoA hydratase; Provisional; Region: PRK09245
318586009413	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586009414	substrate binding site [chemical binding]; other site
318586009415	oxyanion hole (OAH) forming residues; other site
318586009416	trimer interface [polypeptide binding]; other site
318586009417	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
318586009418	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
318586009419	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
318586009420	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
318586009421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586009422	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586009423	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586009424	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586009425	CoenzymeA binding site [chemical binding]; other site
318586009426	subunit interaction site [polypeptide binding]; other site
318586009427	PHB binding site; other site
318586009428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
318586009429	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
318586009430	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
318586009431	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
318586009432	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
318586009433	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586009434	active site
318586009435	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
318586009436	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586009437	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
318586009438	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586009439	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586009440	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
318586009441	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586009442	substrate binding site [chemical binding]; other site
318586009443	oxyanion hole (OAH) forming residues; other site
318586009444	trimer interface [polypeptide binding]; other site
318586009445	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586009446	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
318586009447	dimer interface [polypeptide binding]; other site
318586009448	active site
318586009449	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586009450	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586009451	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586009452	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586009453	NAD(P) binding site [chemical binding]; other site
318586009454	catalytic residues [active]
318586009455	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
318586009456	active site
318586009457	catalytic site [active]
318586009458	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586009459	active site 2 [active]
318586009460	active site 1 [active]
318586009461	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
318586009462	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586009463	acyl-activating enzyme (AAE) consensus motif; other site
318586009464	AMP binding site [chemical binding]; other site
318586009465	active site
318586009466	CoA binding site [chemical binding]; other site
318586009467	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586009468	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
318586009469	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586009470	dimer interface [polypeptide binding]; other site
318586009471	phosphorylation site [posttranslational modification]
318586009472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586009473	ATP binding site [chemical binding]; other site
318586009474	Mg2+ binding site [ion binding]; other site
318586009475	G-X-G motif; other site
318586009476	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586009477	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586009478	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
318586009479	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586009480	catalytic site [active]
318586009481	NADH(P)-binding; Region: NAD_binding_10; pfam13460
318586009482	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
318586009483	NAD(P) binding site [chemical binding]; other site
318586009484	putative active site [active]
318586009485	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009486	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009487	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
318586009488	putative effector binding pocket; other site
318586009489	putative dimerization interface [polypeptide binding]; other site
318586009490	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
318586009491	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
318586009492	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
318586009493	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
318586009494	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586009495	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586009496	active site
318586009497	catalytic tetrad [active]
318586009498	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586009499	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586009500	active site
318586009501	catalytic tetrad [active]
318586009502	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586009503	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586009504	active site
318586009505	catalytic tetrad [active]
318586009506	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
318586009507	DDE superfamily endonuclease; Region: DDE_5; cl17874
318586009508	DDE superfamily endonuclease; Region: DDE_5; cl17874
318586009509	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
318586009510	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
318586009511	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586009512	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
318586009513	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
318586009514	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
318586009515	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
318586009516	catalytic site [active]
318586009517	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
318586009518	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
318586009519	DNA binding residues [nucleotide binding]
318586009520	Transmembrane secretion effector; Region: MFS_3; pfam05977
318586009521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586009522	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
318586009523	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
318586009524	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
318586009525	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
318586009526	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586009527	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586009528	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
318586009529	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586009530	NAD binding site [chemical binding]; other site
318586009531	catalytic residues [active]
318586009532	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
318586009533	Transposase; Region: DDE_Tnp_ISL3; pfam01610
318586009534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
318586009535	Transposase; Region: DDE_Tnp_ISL3; pfam01610
318586009536	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
318586009537	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
318586009538	dimer interface [polypeptide binding]; other site
318586009539	NADP binding site [chemical binding]; other site
318586009540	catalytic residues [active]
318586009541	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
318586009542	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
318586009543	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
318586009544	Amidohydrolase; Region: Amidohydro_2; pfam04909
318586009545	active site
318586009546	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
318586009547	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
318586009548	H+ Antiporter protein; Region: 2A0121; TIGR00900
318586009549	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009552	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586009553	dimerization interface [polypeptide binding]; other site
318586009554	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
318586009555	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
318586009556	Amidohydrolase; Region: Amidohydro_2; pfam04909
318586009557	thiamine pyrophosphate protein; Validated; Region: PRK08199
318586009558	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586009559	PYR/PP interface [polypeptide binding]; other site
318586009560	dimer interface [polypeptide binding]; other site
318586009561	TPP binding site [chemical binding]; other site
318586009562	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586009563	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
318586009564	TPP-binding site [chemical binding]; other site
318586009565	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
318586009566	Amidohydrolase; Region: Amidohydro_2; pfam04909
318586009567	active site
318586009568	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
318586009569	Gram-negative porin; Region: Porin_4; pfam13609
318586009570	Integrase core domain; Region: rve; pfam00665
318586009571	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
318586009572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
318586009573	Transposase; Region: DDE_Tnp_ISL3; pfam01610
318586009574	Transposase; Region: DDE_Tnp_ISL3; pfam01610
318586009575	sensor protein QseC; Provisional; Region: PRK10337
318586009576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586009577	dimer interface [polypeptide binding]; other site
318586009578	phosphorylation site [posttranslational modification]
318586009579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586009580	ATP binding site [chemical binding]; other site
318586009581	Mg2+ binding site [ion binding]; other site
318586009582	G-X-G motif; other site
318586009583	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586009584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586009585	active site
318586009586	phosphorylation site [posttranslational modification]
318586009587	intermolecular recognition site; other site
318586009588	dimerization interface [polypeptide binding]; other site
318586009589	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586009590	DNA binding site [nucleotide binding]
318586009591	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
318586009592	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
318586009593	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
318586009594	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
318586009595	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
318586009596	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
318586009597	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
318586009598	Flavodoxin; Region: Flavodoxin_1; pfam00258
318586009599	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
318586009600	FAD binding pocket [chemical binding]; other site
318586009601	FAD binding motif [chemical binding]; other site
318586009602	catalytic residues [active]
318586009603	NAD binding pocket [chemical binding]; other site
318586009604	phosphate binding motif [ion binding]; other site
318586009605	beta-alpha-beta structure motif; other site
318586009606	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
318586009607	ApbE family; Region: ApbE; pfam02424
318586009608	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009610	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586009611	dimerization interface [polypeptide binding]; other site
318586009612	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
318586009613	metal-binding site [ion binding]
318586009614	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
318586009615	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586009616	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586009617	motif II; other site
318586009618	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
318586009619	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
318586009620	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586009621	Soluble P-type ATPase [General function prediction only]; Region: COG4087
318586009622	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
318586009623	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
318586009624	Walker A/P-loop; other site
318586009625	ATP binding site [chemical binding]; other site
318586009626	Q-loop/lid; other site
318586009627	ABC transporter signature motif; other site
318586009628	Walker B; other site
318586009629	D-loop; other site
318586009630	H-loop/switch region; other site
318586009631	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
318586009632	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586009633	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586009634	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586009635	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
318586009636	Fic family protein [Function unknown]; Region: COG3177
318586009637	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
318586009638	Fic/DOC family; Region: Fic; pfam02661
318586009639	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
318586009640	putative DNA binding site [nucleotide binding]; other site
318586009641	putative Zn2+ binding site [ion binding]; other site
318586009642	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586009643	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
318586009644	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
318586009645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586009646	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
318586009647	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586009648	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
318586009649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586009650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
318586009651	Transposase; Region: HTH_Tnp_1; pfam01527
318586009652	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586009653	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
318586009654	Response regulator receiver domain; Region: Response_reg; pfam00072
318586009655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586009656	active site
318586009657	phosphorylation site [posttranslational modification]
318586009658	intermolecular recognition site; other site
318586009659	dimerization interface [polypeptide binding]; other site
318586009660	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586009661	DNA binding residues [nucleotide binding]
318586009662	dimerization interface [polypeptide binding]; other site
318586009663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586009664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
318586009665	dimer interface [polypeptide binding]; other site
318586009666	phosphorylation site [posttranslational modification]
318586009667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586009668	ATP binding site [chemical binding]; other site
318586009669	Mg2+ binding site [ion binding]; other site
318586009670	G-X-G motif; other site
318586009671	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
318586009672	von Willebrand factor type A domain; Region: VWA_2; pfam13519
318586009673	metal ion-dependent adhesion site (MIDAS); other site
318586009674	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254
318586009675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
318586009676	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
318586009677	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
318586009678	catalytic residues [active]
318586009679	catalytic nucleophile [active]
318586009680	Recombinase; Region: Recombinase; pfam07508
318586009681	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
318586009682	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
318586009683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586009684	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586009685	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
318586009686	Domain of unknown function (DUF955); Region: DUF955; cl01076
318586009687	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
318586009688	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
318586009689	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586009690	Bacterial SH3 domain; Region: SH3_3; pfam08239
318586009691	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
318586009692	Chromate transporter; Region: Chromate_transp; pfam02417
318586009693	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
318586009694	active site residue [active]
318586009695	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
318586009696	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
318586009697	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586009698	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
318586009699	arsenical-resistance protein; Region: acr3; TIGR00832
318586009700	Low molecular weight phosphatase family; Region: LMWPc; cd00115
318586009701	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
318586009702	active site
318586009703	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
318586009704	ArsC family; Region: ArsC; pfam03960
318586009705	catalytic residues [active]
318586009706	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586009707	dimerization interface [polypeptide binding]; other site
318586009708	putative DNA binding site [nucleotide binding]; other site
318586009709	putative Zn2+ binding site [ion binding]; other site
318586009710	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
318586009711	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
318586009712	Sulfate transporter family; Region: Sulfate_transp; pfam00916
318586009713	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
318586009714	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
318586009715	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
318586009716	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586009717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586009718	S-adenosylmethionine binding site [chemical binding]; other site
318586009719	H-NS histone family; Region: Histone_HNS; pfam00816
318586009720	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
318586009721	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
318586009722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586009723	S-adenosylmethionine binding site [chemical binding]; other site
318586009724	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
318586009725	putative metal binding site [ion binding]; other site
318586009726	putative homodimer interface [polypeptide binding]; other site
318586009727	putative homotetramer interface [polypeptide binding]; other site
318586009728	putative homodimer-homodimer interface [polypeptide binding]; other site
318586009729	putative allosteric switch controlling residues; other site
318586009730	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
318586009731	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
318586009732	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
318586009733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586009734	Coenzyme A binding pocket [chemical binding]; other site
318586009735	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
318586009736	DNA methylase; Region: N6_N4_Mtase; cl17433
318586009737	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
318586009738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586009739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
318586009740	Coenzyme A binding pocket [chemical binding]; other site
318586009741	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
318586009742	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
318586009743	dimer interface [polypeptide binding]; other site
318586009744	ssDNA binding site [nucleotide binding]; other site
318586009745	tetramer (dimer of dimers) interface [polypeptide binding]; other site
318586009746	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
318586009747	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
318586009748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586009749	non-specific DNA binding site [nucleotide binding]; other site
318586009750	sequence-specific DNA binding site [nucleotide binding]; other site
318586009751	salt bridge; other site
318586009752	Helix-turn-helix domain; Region: HTH_17; pfam12728
318586009753	Replication initiator protein A; Region: RPA; pfam10134
318586009754	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
318586009755	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
318586009756	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
318586009757	cofactor binding site; other site
318586009758	DNA binding site [nucleotide binding]
318586009759	substrate interaction site [chemical binding]; other site
318586009760	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
318586009761	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
318586009762	Protein of unknown function (DUF736); Region: DUF736; pfam05284
318586009763	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586009764	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586009765	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586009766	catalytic residue [active]
318586009767	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
318586009768	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
318586009769	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
318586009770	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
318586009771	oligomeric interface; other site
318586009772	putative active site [active]
318586009773	homodimer interface [polypeptide binding]; other site
318586009774	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586009775	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586009776	putative aldolase; Validated; Region: PRK08130
318586009777	intersubunit interface [polypeptide binding]; other site
318586009778	active site
318586009779	Zn2+ binding site [ion binding]; other site
318586009780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
318586009781	DctM-like transporters; Region: DctM; pfam06808
318586009782	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
318586009783	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586009784	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
318586009785	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586009786	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586009787	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
318586009788	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
318586009789	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586009790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586009791	DNA-binding site [nucleotide binding]; DNA binding site
318586009792	FCD domain; Region: FCD; pfam07729
318586009793	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
318586009794	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
318586009795	Putative transposase; Region: Y2_Tnp; pfam04986
318586009796	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586009799	dimerization interface [polypeptide binding]; other site
318586009800	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
318586009801	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
318586009802	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
318586009803	dimer interface [polypeptide binding]; other site
318586009804	putative functional site; other site
318586009805	putative MPT binding site; other site
318586009806	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
318586009807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586009808	dimer interface [polypeptide binding]; other site
318586009809	phosphorylation site [posttranslational modification]
318586009810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586009811	ATP binding site [chemical binding]; other site
318586009812	Mg2+ binding site [ion binding]; other site
318586009813	G-X-G motif; other site
318586009814	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586009815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586009816	active site
318586009817	phosphorylation site [posttranslational modification]
318586009818	intermolecular recognition site; other site
318586009819	dimerization interface [polypeptide binding]; other site
318586009820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586009821	DNA binding site [nucleotide binding]
318586009822	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586009823	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586009824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586009825	dimer interface [polypeptide binding]; other site
318586009826	conserved gate region; other site
318586009827	putative PBP binding loops; other site
318586009828	ABC-ATPase subunit interface; other site
318586009829	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586009830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586009831	dimer interface [polypeptide binding]; other site
318586009832	conserved gate region; other site
318586009833	putative PBP binding loops; other site
318586009834	ABC-ATPase subunit interface; other site
318586009835	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
318586009836	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586009837	Walker A/P-loop; other site
318586009838	ATP binding site [chemical binding]; other site
318586009839	Q-loop/lid; other site
318586009840	ABC transporter signature motif; other site
318586009841	Walker B; other site
318586009842	D-loop; other site
318586009843	H-loop/switch region; other site
318586009844	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
318586009845	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586009846	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
318586009847	active site
318586009848	Creatinine amidohydrolase; Region: Creatininase; pfam02633
318586009849	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
318586009850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009852	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
318586009853	putative dimerization interface [polypeptide binding]; other site
318586009854	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
318586009855	hypothetical protein; Validated; Region: PRK08245
318586009856	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
318586009857	putative NAD(P) binding site [chemical binding]; other site
318586009858	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
318586009859	putative active site [active]
318586009860	aspartate aminotransferase; Provisional; Region: PRK05764
318586009861	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586009862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586009863	homodimer interface [polypeptide binding]; other site
318586009864	catalytic residue [active]
318586009865	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
318586009866	homotrimer interaction site [polypeptide binding]; other site
318586009867	putative active site [active]
318586009868	aspartate aminotransferase; Provisional; Region: PRK06207
318586009869	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586009870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586009871	homodimer interface [polypeptide binding]; other site
318586009872	catalytic residue [active]
318586009873	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009875	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
318586009876	putative dimerization interface [polypeptide binding]; other site
318586009877	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
318586009878	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
318586009879	inhibitor site; inhibition site
318586009880	active site
318586009881	dimer interface [polypeptide binding]; other site
318586009882	catalytic residue [active]
318586009883	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
318586009884	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
318586009885	homodimer interface [polypeptide binding]; other site
318586009886	substrate-cofactor binding pocket; other site
318586009887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586009888	catalytic residue [active]
318586009889	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
318586009890	putative active site [active]
318586009891	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586009892	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586009893	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
318586009894	DctM-like transporters; Region: DctM; pfam06808
318586009895	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
318586009896	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
318586009897	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
318586009898	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
318586009899	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586009900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586009901	DNA-binding site [nucleotide binding]; DNA binding site
318586009902	FCD domain; Region: FCD; pfam07729
318586009903	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
318586009904	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
318586009905	ligand binding site [chemical binding]; other site
318586009906	NAD binding site [chemical binding]; other site
318586009907	dimerization interface [polypeptide binding]; other site
318586009908	catalytic site [active]
318586009909	allantoate amidohydrolase; Reviewed; Region: PRK12890
318586009910	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
318586009911	active site
318586009912	metal binding site [ion binding]; metal-binding site
318586009913	dimer interface [polypeptide binding]; other site
318586009914	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586009915	DNA-binding site [nucleotide binding]; DNA binding site
318586009916	Transcriptional regulators [Transcription]; Region: FadR; COG2186
318586009917	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
318586009918	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
318586009919	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
318586009920	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
318586009921	active site
318586009922	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
318586009923	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
318586009924	HAMP domain; Region: HAMP; pfam00672
318586009925	dimerization interface [polypeptide binding]; other site
318586009926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586009927	dimer interface [polypeptide binding]; other site
318586009928	phosphorylation site [posttranslational modification]
318586009929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586009930	ATP binding site [chemical binding]; other site
318586009931	Mg2+ binding site [ion binding]; other site
318586009932	G-X-G motif; other site
318586009933	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586009934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586009935	active site
318586009936	phosphorylation site [posttranslational modification]
318586009937	intermolecular recognition site; other site
318586009938	dimerization interface [polypeptide binding]; other site
318586009939	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586009940	DNA binding site [nucleotide binding]
318586009941	transcription termination factor Rho; Provisional; Region: PRK12678
318586009942	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
318586009943	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
318586009944	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
318586009945	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
318586009946	Walker A/P-loop; other site
318586009947	ATP binding site [chemical binding]; other site
318586009948	Q-loop/lid; other site
318586009949	ABC transporter signature motif; other site
318586009950	Walker B; other site
318586009951	D-loop; other site
318586009952	H-loop/switch region; other site
318586009953	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
318586009954	FtsX-like permease family; Region: FtsX; pfam02687
318586009955	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586009956	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586009957	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586009958	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586009959	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586009960	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586009961	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
318586009962	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
318586009963	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
318586009964	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
318586009965	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586009966	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009967	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586009968	dimerization interface [polypeptide binding]; other site
318586009969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586009970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586009971	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
318586009972	putative substrate binding pocket [chemical binding]; other site
318586009973	dimerization interface [polypeptide binding]; other site
318586009974	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
318586009975	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
318586009976	homotrimer interaction site [polypeptide binding]; other site
318586009977	putative active site [active]
318586009978	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
318586009979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
318586009980	acetylornithine deacetylase; Provisional; Region: PRK07522
318586009981	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
318586009982	metal binding site [ion binding]; metal-binding site
318586009983	putative dimer interface [polypeptide binding]; other site
318586009984	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586009985	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
318586009986	Walker A/P-loop; other site
318586009987	ATP binding site [chemical binding]; other site
318586009988	Q-loop/lid; other site
318586009989	ABC transporter signature motif; other site
318586009990	Walker B; other site
318586009991	D-loop; other site
318586009992	H-loop/switch region; other site
318586009993	TOBE domain; Region: TOBE_2; pfam08402
318586009994	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586009995	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586009996	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586009997	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586009998	dimer interface [polypeptide binding]; other site
318586009999	conserved gate region; other site
318586010000	putative PBP binding loops; other site
318586010001	ABC-ATPase subunit interface; other site
318586010002	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586010003	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586010004	dimer interface [polypeptide binding]; other site
318586010005	conserved gate region; other site
318586010006	putative PBP binding loops; other site
318586010007	ABC-ATPase subunit interface; other site
318586010008	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
318586010009	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
318586010010	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586010011	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
318586010012	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586010013	catalytic loop [active]
318586010014	iron binding site [ion binding]; other site
318586010015	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
318586010016	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
318586010017	[2Fe-2S] cluster binding site [ion binding]; other site
318586010018	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
318586010019	putative alpha subunit interface [polypeptide binding]; other site
318586010020	putative active site [active]
318586010021	putative substrate binding site [chemical binding]; other site
318586010022	Fe binding site [ion binding]; other site
318586010023	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586010024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586010025	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
318586010026	putative substrate binding pocket [chemical binding]; other site
318586010027	dimerization interface [polypeptide binding]; other site
318586010028	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
318586010029	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
318586010030	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
318586010031	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
318586010032	ligand binding site [chemical binding]; other site
318586010033	flexible hinge region; other site
318586010034	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
318586010035	putative switch regulator; other site
318586010036	non-specific DNA interactions [nucleotide binding]; other site
318586010037	DNA binding site [nucleotide binding]
318586010038	sequence specific DNA binding site [nucleotide binding]; other site
318586010039	putative cAMP binding site [chemical binding]; other site
318586010040	Uncharacterized conserved protein [Function unknown]; Region: COG3482
318586010041	Uncharacterized conserved protein [Function unknown]; Region: COG1944
318586010042	YcaO-like family; Region: YcaO; pfam02624
318586010043	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
318586010044	cyclase homology domain; Region: CHD; cd07302
318586010045	nucleotidyl binding site; other site
318586010046	metal binding site [ion binding]; metal-binding site
318586010047	dimer interface [polypeptide binding]; other site
318586010048	Predicted integral membrane protein [Function unknown]; Region: COG5616
318586010049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586010050	TPR motif; other site
318586010051	binding surface
318586010052	Tetratricopeptide repeat; Region: TPR_16; pfam13432
318586010053	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
318586010054	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
318586010055	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
318586010056	potential catalytic triad [active]
318586010057	conserved cys residue [active]
318586010058	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
318586010059	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
318586010060	putative active site [active]
318586010061	putative FMN binding site [chemical binding]; other site
318586010062	putative substrate binding site [chemical binding]; other site
318586010063	putative catalytic residue [active]
318586010064	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
318586010065	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
318586010066	DNA binding residues [nucleotide binding]
318586010067	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586010068	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
318586010069	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586010070	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586010071	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586010072	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586010073	DctM-like transporters; Region: DctM; pfam06808
318586010074	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586010075	Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810
318586010076	active site
318586010077	FMN binding site [chemical binding]; other site
318586010078	substrate binding site [chemical binding]; other site
318586010079	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586010080	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
318586010081	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586010082	MarR family; Region: MarR; pfam01047
318586010083	Transcriptional regulator PadR-like family; Region: PadR; cl17335
318586010084	phenol 2-monooxygenase; Provisional; Region: PRK08294
318586010085	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586010086	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
318586010087	dimer interface [polypeptide binding]; other site
318586010088	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
318586010089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586010090	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586010091	dimerization interface [polypeptide binding]; other site
318586010092	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
318586010093	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
318586010094	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
318586010095	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
318586010096	heterodimer interface [polypeptide binding]; other site
318586010097	multimer interface [polypeptide binding]; other site
318586010098	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
318586010099	active site
318586010100	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
318586010101	heterodimer interface [polypeptide binding]; other site
318586010102	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
318586010103	active site
318586010104	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
318586010105	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
318586010106	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
318586010107	tetramer interface [polypeptide binding]; other site
318586010108	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586010109	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
318586010110	DctM-like transporters; Region: DctM; pfam06808
318586010111	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586010112	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586010113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586010114	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
318586010115	putative effector binding pocket; other site
318586010116	dimerization interface [polypeptide binding]; other site
318586010117	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
318586010118	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586010119	Zn binding site [ion binding]; other site
318586010120	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
318586010121	Zn binding site [ion binding]; other site
318586010122	Predicted esterase [General function prediction only]; Region: COG0400
318586010123	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
318586010124	Isochorismatase family; Region: Isochorismatase; pfam00857
318586010125	catalytic triad [active]
318586010126	dimer interface [polypeptide binding]; other site
318586010127	conserved cis-peptide bond; other site
318586010128	Predicted acetyltransferase [General function prediction only]; Region: COG2388
318586010129	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
318586010130	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
318586010131	active site
318586010132	Transmembrane secretion effector; Region: MFS_3; pfam05977
318586010133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586010134	putative substrate translocation pore; other site
318586010135	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
318586010136	Predicted membrane protein [Function unknown]; Region: COG2259
318586010137	Pirin-related protein [General function prediction only]; Region: COG1741
318586010138	Pirin; Region: Pirin; pfam02678
318586010139	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
318586010140	Predicted membrane protein [Function unknown]; Region: COG1289
318586010141	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
318586010142	transcriptional regulator SlyA; Provisional; Region: PRK03573
318586010143	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
318586010144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586010145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586010146	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586010147	dimerization interface [polypeptide binding]; other site
318586010148	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
318586010149	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586010150	active site
318586010151	allantoate amidohydrolase; Reviewed; Region: PRK12893
318586010152	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
318586010153	active site
318586010154	metal binding site [ion binding]; metal-binding site
318586010155	dimer interface [polypeptide binding]; other site
318586010156	Protein of unknown function (DUF917); Region: DUF917; pfam06032
318586010157	Urocanase; Region: Urocanase; pfam01175
318586010158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586010159	metabolite-proton symporter; Region: 2A0106; TIGR00883
318586010160	putative substrate translocation pore; other site
318586010161	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
318586010162	active sites [active]
318586010163	tetramer interface [polypeptide binding]; other site
318586010164	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586010165	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586010166	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586010167	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
318586010168	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586010169	N-terminal plug; other site
318586010170	ligand-binding site [chemical binding]; other site
318586010171	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
318586010172	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
318586010173	siderophore binding site; other site
318586010174	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586010175	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586010176	ABC-ATPase subunit  interface; other site
318586010177	dimer interface [polypeptide binding]; other site
318586010178	putative PBP binding regions; other site
318586010179	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586010180	ABC-ATPase subunit  interface; other site
318586010181	dimer interface [polypeptide binding]; other site
318586010182	putative PBP binding regions; other site
318586010183	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586010184	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586010185	Walker A/P-loop; other site
318586010186	ATP binding site [chemical binding]; other site
318586010187	Q-loop/lid; other site
318586010188	ABC transporter signature motif; other site
318586010189	Walker B; other site
318586010190	D-loop; other site
318586010191	H-loop/switch region; other site
318586010192	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
318586010193	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
318586010194	active site
318586010195	non-prolyl cis peptide bond; other site
318586010196	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586010197	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586010198	N-terminal plug; other site
318586010199	ligand-binding site [chemical binding]; other site
318586010200	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
318586010201	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586010202	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586010203	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586010204	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586010205	Walker A/P-loop; other site
318586010206	ATP binding site [chemical binding]; other site
318586010207	Q-loop/lid; other site
318586010208	ABC transporter signature motif; other site
318586010209	Walker B; other site
318586010210	D-loop; other site
318586010211	H-loop/switch region; other site
318586010212	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
318586010213	FAD binding pocket [chemical binding]; other site
318586010214	FAD binding motif [chemical binding]; other site
318586010215	phosphate binding motif [ion binding]; other site
318586010216	NAD binding pocket [chemical binding]; other site
318586010217	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
318586010218	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586010219	intersubunit interface [polypeptide binding]; other site
318586010220	FecCD transport family; Region: FecCD; pfam01032
318586010221	dimer interface [polypeptide binding]; other site
318586010222	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586010223	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586010224	ABC-ATPase subunit  interface; other site
318586010225	putative PBP binding regions; other site
318586010226	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
318586010227	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586010228	ABC-ATPase subunit  interface; other site
318586010229	dimer interface [polypeptide binding]; other site
318586010230	putative PBP binding regions; other site
318586010231	putative glutathione S-transferase; Provisional; Region: PRK10357
318586010232	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
318586010233	putative C-terminal domain interface [polypeptide binding]; other site
318586010234	putative GSH binding site (G-site) [chemical binding]; other site
318586010235	putative dimer interface [polypeptide binding]; other site
318586010236	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
318586010237	dimer interface [polypeptide binding]; other site
318586010238	N-terminal domain interface [polypeptide binding]; other site
318586010239	putative substrate binding pocket (H-site) [chemical binding]; other site
318586010240	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586010241	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586010242	DNA-binding site [nucleotide binding]; DNA binding site
318586010243	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
318586010244	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586010245	classical (c) SDRs; Region: SDR_c; cd05233
318586010246	NAD(P) binding site [chemical binding]; other site
318586010247	active site
318586010248	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
318586010249	DctM-like transporters; Region: DctM; pfam06808
318586010250	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586010251	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586010252	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586010253	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586010254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586010255	NAD(P) binding site [chemical binding]; other site
318586010256	active site
318586010257	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
318586010258	classical (c) SDRs; Region: SDR_c; cd05233
318586010259	NAD(P) binding site [chemical binding]; other site
318586010260	active site
318586010261	putative succinate dehydrogenase; Reviewed; Region: PRK12842
318586010262	Predicted oxidoreductase [General function prediction only]; Region: COG3573
318586010263	SnoaL-like domain; Region: SnoaL_4; pfam13577
318586010264	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586010265	MarR family; Region: MarR_2; cl17246
318586010266	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586010267	MarR family; Region: MarR_2; pfam12802
318586010268	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
318586010269	fumarylacetoacetase; Region: PLN02856
318586010270	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
318586010271	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
318586010272	maleylacetoacetate isomerase; Region: maiA; TIGR01262
318586010273	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
318586010274	C-terminal domain interface [polypeptide binding]; other site
318586010275	GSH binding site (G-site) [chemical binding]; other site
318586010276	putative dimer interface [polypeptide binding]; other site
318586010277	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586010278	substrate binding pocket (H-site) [chemical binding]; other site
318586010279	N-terminal domain interface [polypeptide binding]; other site
318586010280	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
318586010281	ligand binding site; other site
318586010282	tetramer interface; other site
318586010283	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
318586010284	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
318586010285	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586010286	extended (e) SDRs; Region: SDR_e; cd08946
318586010287	NAD(P) binding site [chemical binding]; other site
318586010288	active site
318586010289	substrate binding site [chemical binding]; other site
318586010290	Asparagine synthase; Region: Asn_synthase; pfam00733
318586010291	pseudaminic acid synthase; Region: PseI; TIGR03586
318586010292	NeuB family; Region: NeuB; pfam03102
318586010293	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
318586010294	NeuB binding interface [polypeptide binding]; other site
318586010295	putative substrate binding site [chemical binding]; other site
318586010296	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
318586010297	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
318586010298	inhibitor-cofactor binding pocket; inhibition site
318586010299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586010300	catalytic residue [active]
318586010301	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
318586010302	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
318586010303	NAD(P) binding site [chemical binding]; other site
318586010304	homodimer interface [polypeptide binding]; other site
318586010305	substrate binding site [chemical binding]; other site
318586010306	active site
318586010307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586010308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586010309	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586010310	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586010311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
318586010312	Transposase; Region: HTH_Tnp_1; cl17663
318586010313	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586010314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586010315	active site
318586010316	phosphorylation site [posttranslational modification]
318586010317	intermolecular recognition site; other site
318586010318	dimerization interface [polypeptide binding]; other site
318586010319	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586010320	DNA binding site [nucleotide binding]
318586010321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586010322	active site
318586010323	phosphorylation site [posttranslational modification]
318586010324	intermolecular recognition site; other site
318586010325	dimerization interface [polypeptide binding]; other site
318586010326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586010327	dimer interface [polypeptide binding]; other site
318586010328	phosphorylation site [posttranslational modification]
318586010329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586010330	ATP binding site [chemical binding]; other site
318586010331	Mg2+ binding site [ion binding]; other site
318586010332	G-X-G motif; other site
318586010333	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
318586010334	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586010335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586010336	dimer interface [polypeptide binding]; other site
318586010337	phosphorylation site [posttranslational modification]
318586010338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586010339	ATP binding site [chemical binding]; other site
318586010340	Mg2+ binding site [ion binding]; other site
318586010341	G-X-G motif; other site
318586010342	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
318586010343	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
318586010344	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
318586010345	short chain dehydrogenase; Provisional; Region: PRK12829
318586010346	classical (c) SDRs; Region: SDR_c; cd05233
318586010347	NAD(P) binding site [chemical binding]; other site
318586010348	active site
318586010349	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586010350	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586010351	DNA-binding site [nucleotide binding]; DNA binding site
318586010352	FCD domain; Region: FCD; pfam07729
318586010353	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586010354	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
318586010355	putative ligand binding site [chemical binding]; other site
318586010356	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586010357	TM-ABC transporter signature motif; other site
318586010358	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586010359	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586010360	TM-ABC transporter signature motif; other site
318586010361	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586010362	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586010363	Walker A/P-loop; other site
318586010364	ATP binding site [chemical binding]; other site
318586010365	Q-loop/lid; other site
318586010366	ABC transporter signature motif; other site
318586010367	Walker B; other site
318586010368	D-loop; other site
318586010369	H-loop/switch region; other site
318586010370	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586010371	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586010372	Walker A/P-loop; other site
318586010373	ATP binding site [chemical binding]; other site
318586010374	Q-loop/lid; other site
318586010375	ABC transporter signature motif; other site
318586010376	Walker B; other site
318586010377	D-loop; other site
318586010378	H-loop/switch region; other site
318586010379	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
318586010380	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586010381	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586010382	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
318586010383	histidinol dehydrogenase; Region: hisD; TIGR00069
318586010384	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
318586010385	NAD binding site [chemical binding]; other site
318586010386	dimerization interface [polypeptide binding]; other site
318586010387	product binding site; other site
318586010388	substrate binding site [chemical binding]; other site
318586010389	zinc binding site [ion binding]; other site
318586010390	catalytic residues [active]
318586010391	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586010392	classical (c) SDRs; Region: SDR_c; cd05233
318586010393	NAD(P) binding site [chemical binding]; other site
318586010394	active site
318586010395	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586010396	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586010397	DNA binding residues [nucleotide binding]
318586010398	dimerization interface [polypeptide binding]; other site
318586010399	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
318586010400	classical (c) SDRs; Region: SDR_c; cd05233
318586010401	NAD(P) binding site [chemical binding]; other site
318586010402	active site
318586010403	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
318586010404	FAD binding domain; Region: FAD_binding_4; pfam01565
318586010405	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
318586010406	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
318586010407	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
318586010408	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
318586010409	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586010410	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
318586010411	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
318586010412	active site
318586010413	RelB antitoxin; Region: RelB; cl01171
318586010414	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
318586010415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586010416	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
318586010417	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586010418	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
318586010419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586010420	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
318586010421	tape measure domain; Region: tape_meas_nterm; TIGR02675
318586010422	putative lipoprotein; Provisional; Region: PRK10533
318586010423	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
318586010424	active site
318586010425	catalytic triad [active]
318586010426	oxyanion hole [active]
318586010427	Predicted chitinase [General function prediction only]; Region: COG3179
318586010428	catalytic residue [active]
318586010429	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586010430	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
318586010431	Found in ATP-dependent protease La (LON); Region: LON; smart00464
318586010432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586010433	Walker A motif; other site
318586010434	ATP binding site [chemical binding]; other site
318586010435	Walker B motif; other site
318586010436	arginine finger; other site
318586010437	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
318586010438	CsbD-like; Region: CsbD; cl17424
318586010439	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
318586010440	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586010441	active site
318586010442	HIGH motif; other site
318586010443	nucleotide binding site [chemical binding]; other site
318586010444	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
318586010445	active site
318586010446	KMSKS motif; other site
318586010447	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
318586010448	tRNA binding surface [nucleotide binding]; other site
318586010449	anticodon binding site; other site
318586010450	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
318586010451	putative monooxygenase; Reviewed; Region: PRK07045
318586010452	hypothetical protein; Provisional; Region: PRK07236
318586010453	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
318586010454	heme-binding site [chemical binding]; other site
318586010455	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586010456	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
318586010457	Predicted membrane protein [Function unknown]; Region: COG2860
318586010458	UPF0126 domain; Region: UPF0126; pfam03458
318586010459	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
318586010460	RNA/DNA hybrid binding site [nucleotide binding]; other site
318586010461	active site
318586010462	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586010463	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
318586010464	putative C-terminal domain interface [polypeptide binding]; other site
318586010465	putative GSH binding site (G-site) [chemical binding]; other site
318586010466	putative dimer interface [polypeptide binding]; other site
318586010467	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586010468	N-terminal domain interface [polypeptide binding]; other site
318586010469	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
318586010470	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
318586010471	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586010472	active site
318586010473	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
318586010474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586010475	Coenzyme A binding pocket [chemical binding]; other site
318586010476	C-lysozyme inhibitor; Provisional; Region: PRK09993
318586010477	EcsC protein family; Region: EcsC; pfam12787
318586010478	AAA domain; Region: AAA_30; pfam13604
318586010479	Family description; Region: UvrD_C_2; pfam13538
318586010480	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586010481	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
318586010482	putative DNA binding site [nucleotide binding]; other site
318586010483	putative Zn2+ binding site [ion binding]; other site
318586010484	AsnC family; Region: AsnC_trans_reg; pfam01037
318586010485	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
318586010486	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
318586010487	substrate binding site [chemical binding]; other site
318586010488	active site
318586010489	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
318586010490	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
318586010491	domain interfaces; other site
318586010492	active site
318586010493	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
318586010494	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
318586010495	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
318586010496	isovaleryl-CoA dehydrogenase; Region: PLN02519
318586010497	substrate binding site [chemical binding]; other site
318586010498	FAD binding site [chemical binding]; other site
318586010499	catalytic base [active]
318586010500	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
318586010501	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
318586010502	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
318586010503	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
318586010504	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
318586010505	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
318586010506	putative ADP-ribose binding site [chemical binding]; other site
318586010507	putative active site [active]
318586010508	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
318586010509	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586010510	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586010511	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
318586010512	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
318586010513	carboxyltransferase (CT) interaction site; other site
318586010514	biotinylation site [posttranslational modification]; other site
318586010515	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
318586010516	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
318586010517	putative C-terminal domain interface [polypeptide binding]; other site
318586010518	putative GSH binding site (G-site) [chemical binding]; other site
318586010519	putative dimer interface [polypeptide binding]; other site
318586010520	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
318586010521	N-terminal domain interface [polypeptide binding]; other site
318586010522	dimer interface [polypeptide binding]; other site
318586010523	substrate binding pocket (H-site) [chemical binding]; other site
318586010524	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
318586010525	active site
318586010526	catalytic residues [active]
318586010527	metal binding site [ion binding]; metal-binding site
318586010528	enoyl-CoA hydratase; Provisional; Region: PRK07468
318586010529	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586010530	substrate binding site [chemical binding]; other site
318586010531	oxyanion hole (OAH) forming residues; other site
318586010532	trimer interface [polypeptide binding]; other site
318586010533	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
318586010534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586010535	putative substrate translocation pore; other site
318586010536	Protein of unknown function, DUF599; Region: DUF599; pfam04654
318586010537	Protein of unknown function (DUF465); Region: DUF465; cl01070
318586010538	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
318586010539	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
318586010540	putative dimer interface [polypeptide binding]; other site
318586010541	recombination protein RecR; Reviewed; Region: recR; PRK00076
318586010542	RecR protein; Region: RecR; pfam02132
318586010543	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
318586010544	putative active site [active]
318586010545	putative metal-binding site [ion binding]; other site
318586010546	tetramer interface [polypeptide binding]; other site
318586010547	hypothetical protein; Validated; Region: PRK00153
318586010548	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
318586010549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586010550	Walker A motif; other site
318586010551	ATP binding site [chemical binding]; other site
318586010552	Walker B motif; other site
318586010553	arginine finger; other site
318586010554	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
318586010555	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
318586010556	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
318586010557	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
318586010558	amphipathic channel; other site
318586010559	Asn-Pro-Ala signature motifs; other site
318586010560	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
318586010561	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586010562	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
318586010563	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
318586010564	DNA-binding site [nucleotide binding]; DNA binding site
318586010565	RNA-binding motif; other site
318586010566	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
318586010567	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
318586010568	ring oligomerisation interface [polypeptide binding]; other site
318586010569	ATP/Mg binding site [chemical binding]; other site
318586010570	stacking interactions; other site
318586010571	hinge regions; other site
318586010572	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
318586010573	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586010574	TraB family; Region: TraB; pfam01963
318586010575	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
318586010576	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
318586010577	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
318586010578	DHHA2 domain; Region: DHHA2; pfam02833
318586010579	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
318586010580	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
318586010581	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
318586010582	dimer interaction site [polypeptide binding]; other site
318586010583	substrate-binding tunnel; other site
318586010584	active site
318586010585	catalytic site [active]
318586010586	substrate binding site [chemical binding]; other site
318586010587	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
318586010588	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
318586010589	active site
318586010590	Riboflavin kinase; Region: Flavokinase; pfam01687
318586010591	hypothetical protein; Provisional; Region: PRK05170
318586010592	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
318586010593	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
318586010594	tetramer interface [polypeptide binding]; other site
318586010595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586010596	catalytic residue [active]
318586010597	Competence-damaged protein; Region: CinA; pfam02464
318586010598	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
318586010599	tetramer interfaces [polypeptide binding]; other site
318586010600	binuclear metal-binding site [ion binding]; other site
318586010601	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
318586010602	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
318586010603	substrate binding site; other site
318586010604	dimer interface; other site
318586010605	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
318586010606	homotrimer interaction site [polypeptide binding]; other site
318586010607	zinc binding site [ion binding]; other site
318586010608	CDP-binding sites; other site
318586010609	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
318586010610	tetramer (dimer of dimers) interface [polypeptide binding]; other site
318586010611	active site
318586010612	dimer interface [polypeptide binding]; other site
318586010613	glutathione reductase; Validated; Region: PRK06116
318586010614	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586010615	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586010616	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
318586010617	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
318586010618	HflK protein; Region: hflK; TIGR01933
318586010619	HflC protein; Region: hflC; TIGR01932
318586010620	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
318586010621	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
318586010622	Domain of unknown function DUF20; Region: UPF0118; pfam01594
318586010623	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
318586010624	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
318586010625	nudix motif; other site
318586010626	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
318586010627	TIGR02300 family protein; Region: FYDLN_acid
318586010628	Protein of unknown function DUF45; Region: DUF45; pfam01863
318586010629	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586010630	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
318586010631	DNA-binding site [nucleotide binding]; DNA binding site
318586010632	FCD domain; Region: FCD; pfam07729
318586010633	homoserine dehydrogenase; Provisional; Region: PRK06349
318586010634	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
318586010635	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
318586010636	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
318586010637	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
318586010638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586010639	Coenzyme A binding pocket [chemical binding]; other site
318586010640	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
318586010641	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
318586010642	active site
318586010643	substrate binding site [chemical binding]; other site
318586010644	coenzyme B12 binding site [chemical binding]; other site
318586010645	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
318586010646	B12 binding site [chemical binding]; other site
318586010647	cobalt ligand [ion binding]; other site
318586010648	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
318586010649	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
318586010650	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586010651	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
318586010652	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
318586010653	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
318586010654	carboxyltransferase (CT) interaction site; other site
318586010655	biotinylation site [posttranslational modification]; other site
318586010656	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
318586010657	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
318586010658	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
318586010659	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
318586010660	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
318586010661	dimer interface [polypeptide binding]; other site
318586010662	active site
318586010663	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586010664	substrate binding site [chemical binding]; other site
318586010665	catalytic residues [active]
318586010666	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
318586010667	Permease; Region: Permease; pfam02405
318586010668	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
318586010669	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
318586010670	Walker A/P-loop; other site
318586010671	ATP binding site [chemical binding]; other site
318586010672	Q-loop/lid; other site
318586010673	ABC transporter signature motif; other site
318586010674	Walker B; other site
318586010675	D-loop; other site
318586010676	H-loop/switch region; other site
318586010677	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
318586010678	PhoH-like protein; Region: PhoH; pfam02562
318586010679	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
318586010680	FOG: CBS domain [General function prediction only]; Region: COG0517
318586010681	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
318586010682	Transporter associated domain; Region: CorC_HlyC; smart01091
318586010683	Uncharacterized conserved protein [Function unknown]; Region: COG1359
318586010684	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
318586010685	GMP synthase; Reviewed; Region: guaA; PRK00074
318586010686	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
318586010687	AMP/PPi binding site [chemical binding]; other site
318586010688	candidate oxyanion hole; other site
318586010689	catalytic triad [active]
318586010690	potential glutamine specificity residues [chemical binding]; other site
318586010691	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
318586010692	ATP Binding subdomain [chemical binding]; other site
318586010693	Ligand Binding sites [chemical binding]; other site
318586010694	Dimerization subdomain; other site
318586010695	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
318586010696	thiamine phosphate binding site [chemical binding]; other site
318586010697	active site
318586010698	pyrophosphate binding site [ion binding]; other site
318586010699	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
318586010700	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
318586010701	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
318586010702	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
318586010703	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
318586010704	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
318586010705	active site
318586010706	Zn binding site [ion binding]; other site
318586010707	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
318586010708	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
318586010709	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586010710	FeS/SAM binding site; other site
318586010711	TRAM domain; Region: TRAM; pfam01938
318586010712	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
318586010713	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
318586010714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586010715	dimer interface [polypeptide binding]; other site
318586010716	conserved gate region; other site
318586010717	putative PBP binding loops; other site
318586010718	ABC-ATPase subunit interface; other site
318586010719	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586010720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586010721	dimer interface [polypeptide binding]; other site
318586010722	conserved gate region; other site
318586010723	putative PBP binding loops; other site
318586010724	ABC-ATPase subunit interface; other site
318586010725	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586010726	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586010727	substrate binding pocket [chemical binding]; other site
318586010728	membrane-bound complex binding site; other site
318586010729	hinge residues; other site
318586010730	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
318586010731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586010732	Walker A/P-loop; other site
318586010733	ATP binding site [chemical binding]; other site
318586010734	Q-loop/lid; other site
318586010735	ABC transporter signature motif; other site
318586010736	Walker B; other site
318586010737	D-loop; other site
318586010738	H-loop/switch region; other site
318586010739	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
318586010740	putative metal binding site [ion binding]; other site
318586010741	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
318586010742	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
318586010743	CTP synthetase; Validated; Region: pyrG; PRK05380
318586010744	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
318586010745	Catalytic site [active]
318586010746	active site
318586010747	UTP binding site [chemical binding]; other site
318586010748	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
318586010749	active site
318586010750	putative oxyanion hole; other site
318586010751	catalytic triad [active]
318586010752	Preprotein translocase SecG subunit; Region: SecG; pfam03840
318586010753	cobyric acid synthase; Provisional; Region: PRK00784
318586010754	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
318586010755	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
318586010756	catalytic triad [active]
318586010757	classical (c) SDRs; Region: SDR_c; cd05233
318586010758	NAD(P) binding site [chemical binding]; other site
318586010759	active site
318586010760	Protein of unknown function (DUF1284); Region: DUF1284; pfam06935
318586010761	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
318586010762	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
318586010763	dimer interface [polypeptide binding]; other site
318586010764	active site
318586010765	citrylCoA binding site [chemical binding]; other site
318586010766	NADH binding [chemical binding]; other site
318586010767	cationic pore residues; other site
318586010768	oxalacetate/citrate binding site [chemical binding]; other site
318586010769	coenzyme A binding site [chemical binding]; other site
318586010770	catalytic triad [active]
318586010771	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
318586010772	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
318586010773	HIGH motif; other site
318586010774	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
318586010775	active site
318586010776	KMSKS motif; other site
318586010777	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
318586010778	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
318586010779	Competence protein; Region: Competence; pfam03772
318586010780	Heme NO binding; Region: HNOB; pfam07700
318586010781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
318586010782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
318586010783	metal binding site [ion binding]; metal-binding site
318586010784	active site
318586010785	I-site; other site
318586010786	Autoinducer binding domain; Region: Autoind_bind; pfam03472
318586010787	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586010788	DNA binding residues [nucleotide binding]
318586010789	dimerization interface [polypeptide binding]; other site
318586010790	elongation factor Ts; Provisional; Region: tsf; PRK09377
318586010791	UBA/TS-N domain; Region: UBA; pfam00627
318586010792	Elongation factor TS; Region: EF_TS; pfam00889
318586010793	Elongation factor TS; Region: EF_TS; pfam00889
318586010794	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
318586010795	rRNA interaction site [nucleotide binding]; other site
318586010796	S8 interaction site; other site
318586010797	putative laminin-1 binding site; other site
318586010798	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586010799	active site
318586010800	catalytic residues [active]
318586010801	DNA binding site [nucleotide binding]
318586010802	Int/Topo IB signature motif; other site
318586010803	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586010804	active site
318586010805	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
318586010806	Zn binding site [ion binding]; other site
318586010807	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
318586010808	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
318586010809	RecT family; Region: RecT; cl04285
318586010810	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
318586010811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586010812	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586010813	non-specific DNA binding site [nucleotide binding]; other site
318586010814	salt bridge; other site
318586010815	sequence-specific DNA binding site [nucleotide binding]; other site
318586010816	hypothetical protein; Provisional; Region: PRK06922
318586010817	Phage terminase large subunit; Region: Terminase_3; cl12054
318586010818	Terminase-like family; Region: Terminase_6; pfam03237
318586010819	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
318586010820	hypothetical protein; Region: PHA00670
318586010821	putative protease; Region: PHA00666
318586010822	major capsid protein; Region: PHA00665
318586010823	hypothetical protein; Region: PHA00664
318586010824	Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876
318586010825	hypothetical protein; Region: PHA00662
318586010826	hypothetical protein; Region: PHA00661
318586010827	hypothetical protein; Region: PHA01733
318586010828	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586010829	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586010830	catalytic residue [active]
318586010831	virion protein; Provisional; Region: PHA03414
318586010832	structural protein; Region: PHA01972
318586010833	Arc-like DNA binding domain; Region: Arc; pfam03869
318586010834	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
318586010835	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
318586010836	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
318586010837	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
318586010838	active site
318586010839	metal binding site [ion binding]; metal-binding site
318586010840	Predicted chitinase [General function prediction only]; Region: COG3179
318586010841	catalytic residue [active]
318586010842	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586010843	cytidylate kinase; Provisional; Region: cmk; PRK00023
318586010844	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
318586010845	CMP-binding site; other site
318586010846	The sites determining sugar specificity; other site
318586010847	Nitronate monooxygenase; Region: NMO; pfam03060
318586010848	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
318586010849	FMN binding site [chemical binding]; other site
318586010850	substrate binding site [chemical binding]; other site
318586010851	putative catalytic residue [active]
318586010852	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
318586010853	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
318586010854	RNA binding site [nucleotide binding]; other site
318586010855	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
318586010856	RNA binding site [nucleotide binding]; other site
318586010857	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
318586010858	RNA binding site [nucleotide binding]; other site
318586010859	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
318586010860	RNA binding site [nucleotide binding]; other site
318586010861	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
318586010862	RNA binding site [nucleotide binding]; other site
318586010863	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
318586010864	RNA binding site [nucleotide binding]; other site
318586010865	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
318586010866	IHF dimer interface [polypeptide binding]; other site
318586010867	IHF - DNA interface [nucleotide binding]; other site
318586010868	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
318586010869	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
318586010870	active site
318586010871	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586010872	Coenzyme A binding pocket [chemical binding]; other site
318586010873	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
318586010874	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
318586010875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586010876	catalytic residue [active]
318586010877	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
318586010878	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
318586010879	catalytic residues [active]
318586010880	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
318586010881	hypothetical protein; Provisional; Region: PRK11171
318586010882	Cupin domain; Region: Cupin_2; pfam07883
318586010883	Cupin domain; Region: Cupin_2; pfam07883
318586010884	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
318586010885	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
318586010886	active site
318586010887	catalytic site [active]
318586010888	tetramer interface [polypeptide binding]; other site
318586010889	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
318586010890	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
318586010891	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
318586010892	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
318586010893	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
318586010894	putative active site [active]
318586010895	hypothetical protein; Provisional; Region: PRK07483
318586010896	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586010897	inhibitor-cofactor binding pocket; inhibition site
318586010898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586010899	catalytic residue [active]
318586010900	Uncharacterized conserved protein [Function unknown]; Region: COG5476
318586010901	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
318586010902	MlrC C-terminus; Region: MlrC_C; pfam07171
318586010903	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
318586010904	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586010905	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586010906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586010907	dimer interface [polypeptide binding]; other site
318586010908	conserved gate region; other site
318586010909	putative PBP binding loops; other site
318586010910	ABC-ATPase subunit interface; other site
318586010911	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
318586010912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586010913	dimer interface [polypeptide binding]; other site
318586010914	conserved gate region; other site
318586010915	putative PBP binding loops; other site
318586010916	ABC-ATPase subunit interface; other site
318586010917	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586010918	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586010919	Walker A/P-loop; other site
318586010920	ATP binding site [chemical binding]; other site
318586010921	Q-loop/lid; other site
318586010922	ABC transporter signature motif; other site
318586010923	Walker B; other site
318586010924	D-loop; other site
318586010925	H-loop/switch region; other site
318586010926	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586010927	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586010928	Walker A/P-loop; other site
318586010929	ATP binding site [chemical binding]; other site
318586010930	Q-loop/lid; other site
318586010931	ABC transporter signature motif; other site
318586010932	Walker B; other site
318586010933	D-loop; other site
318586010934	H-loop/switch region; other site
318586010935	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586010936	Predicted amidohydrolase [General function prediction only]; Region: COG0388
318586010937	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
318586010938	active site
318586010939	catalytic triad [active]
318586010940	dimer interface [polypeptide binding]; other site
318586010941	Uncharacterized conserved protein [Function unknown]; Region: COG2128
318586010942	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
318586010943	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
318586010944	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
318586010945	dimer interface [polypeptide binding]; other site
318586010946	ssDNA binding site [nucleotide binding]; other site
318586010947	tetramer (dimer of dimers) interface [polypeptide binding]; other site
318586010948	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
318586010949	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
318586010950	N-acetyl-D-glucosamine binding site [chemical binding]; other site
318586010951	catalytic residue [active]
318586010952	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
318586010953	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
318586010954	dimer interface [polypeptide binding]; other site
318586010955	active site
318586010956	aspartate-rich active site metal binding site; other site
318586010957	allosteric magnesium binding site [ion binding]; other site
318586010958	Schiff base residues; other site
318586010959	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
318586010960	Flavivirus non-structural Protein NS1; Region: Flavi_NS1; pfam00948
318586010961	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
318586010962	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586010963	ATP binding site [chemical binding]; other site
318586010964	putative Mg++ binding site [ion binding]; other site
318586010965	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586010966	nucleotide binding region [chemical binding]; other site
318586010967	ATP-binding site [chemical binding]; other site
318586010968	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
318586010969	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
318586010970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586010971	Walker A motif; other site
318586010972	ATP binding site [chemical binding]; other site
318586010973	Walker B motif; other site
318586010974	arginine finger; other site
318586010975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586010976	Walker A motif; other site
318586010977	ATP binding site [chemical binding]; other site
318586010978	Walker B motif; other site
318586010979	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
318586010980	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
318586010981	Methyltransferase domain; Region: Methyltransf_23; pfam13489
318586010982	Methyltransferase domain; Region: Methyltransf_11; pfam08241
318586010983	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
318586010984	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
318586010985	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
318586010986	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
318586010987	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
318586010988	beta subunit interaction interface [polypeptide binding]; other site
318586010989	Walker A motif; other site
318586010990	ATP binding site [chemical binding]; other site
318586010991	Walker B motif; other site
318586010992	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
318586010993	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
318586010994	core domain interface [polypeptide binding]; other site
318586010995	delta subunit interface [polypeptide binding]; other site
318586010996	epsilon subunit interface [polypeptide binding]; other site
318586010997	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
318586010998	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
318586010999	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
318586011000	alpha subunit interaction interface [polypeptide binding]; other site
318586011001	Walker A motif; other site
318586011002	ATP binding site [chemical binding]; other site
318586011003	Walker B motif; other site
318586011004	inhibitor binding site; inhibition site
318586011005	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
318586011006	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443
318586011007	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
318586011008	gamma subunit interface [polypeptide binding]; other site
318586011009	epsilon subunit interface [polypeptide binding]; other site
318586011010	LBP interface [polypeptide binding]; other site
318586011011	H-type lectin domain; Region: H_lectin; pfam09458
318586011012	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586011013	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
318586011014	catalytic site [active]
318586011015	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
318586011016	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
318586011017	putative catalytic residue [active]
318586011018	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
318586011019	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
318586011020	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586011021	active site
318586011022	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
318586011023	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
318586011024	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
318586011025	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
318586011026	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
318586011027	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
318586011028	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
318586011029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011030	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
318586011031	Walker A motif; other site
318586011032	ATP binding site [chemical binding]; other site
318586011033	Walker B motif; other site
318586011034	arginine finger; other site
318586011035	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
318586011036	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
318586011037	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586011038	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586011039	non-specific DNA binding site [nucleotide binding]; other site
318586011040	salt bridge; other site
318586011041	sequence-specific DNA binding site [nucleotide binding]; other site
318586011042	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
318586011043	DNA methylase; Region: N6_N4_Mtase; pfam01555
318586011044	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
318586011045	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586011046	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
318586011047	ATP binding site [chemical binding]; other site
318586011048	putative Mg++ binding site [ion binding]; other site
318586011049	nucleotide binding region [chemical binding]; other site
318586011050	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
318586011051	ATP-binding site [chemical binding]; other site
318586011052	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
318586011053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
318586011054	Transposase; Region: DEDD_Tnp_IS110; pfam01548
318586011055	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
318586011056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
318586011057	Transposase; Region: HTH_Tnp_1; cl17663
318586011058	putative transposase OrfB; Reviewed; Region: PHA02517
318586011059	HTH-like domain; Region: HTH_21; pfam13276
318586011060	Integrase core domain; Region: rve; pfam00665
318586011061	Integrase core domain; Region: rve_3; pfam13683
318586011062	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586011063	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586011064	non-specific DNA binding site [nucleotide binding]; other site
318586011065	salt bridge; other site
318586011066	sequence-specific DNA binding site [nucleotide binding]; other site
318586011067	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586011068	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
318586011069	active site
318586011070	catalytic residues [active]
318586011071	DNA binding site [nucleotide binding]
318586011072	Int/Topo IB signature motif; other site
318586011073	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
318586011074	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
318586011075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586011076	dimer interface [polypeptide binding]; other site
318586011077	conserved gate region; other site
318586011078	putative PBP binding loops; other site
318586011079	ABC-ATPase subunit interface; other site
318586011080	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586011081	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586011082	Walker A/P-loop; other site
318586011083	ATP binding site [chemical binding]; other site
318586011084	Q-loop/lid; other site
318586011085	ABC transporter signature motif; other site
318586011086	Walker B; other site
318586011087	D-loop; other site
318586011088	H-loop/switch region; other site
318586011089	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
318586011090	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
318586011091	dimer interface [polypeptide binding]; other site
318586011092	ADP-ribose binding site [chemical binding]; other site
318586011093	active site
318586011094	nudix motif; other site
318586011095	metal binding site [ion binding]; metal-binding site
318586011096	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
318586011097	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
318586011098	dimer interface [polypeptide binding]; other site
318586011099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586011100	catalytic residue [active]
318586011101	Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304
318586011102	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
318586011103	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
318586011104	Mechanosensitive ion channel; Region: MS_channel; pfam00924
318586011105	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
318586011106	dimer interface [polypeptide binding]; other site
318586011107	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586011108	ligand binding site [chemical binding]; other site
318586011109	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
318586011110	DNA gyrase subunit A; Validated; Region: PRK05560
318586011111	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
318586011112	CAP-like domain; other site
318586011113	active site
318586011114	primary dimer interface [polypeptide binding]; other site
318586011115	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
318586011116	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
318586011117	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
318586011118	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
318586011119	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
318586011120	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
318586011121	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
318586011122	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
318586011123	Predicted metalloprotease [General function prediction only]; Region: COG2321
318586011124	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
318586011125	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
318586011126	putative coenzyme Q binding site [chemical binding]; other site
318586011127	glutamate dehydrogenase; Provisional; Region: PRK09414
318586011128	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
318586011129	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
318586011130	NAD(P) binding site [chemical binding]; other site
318586011131	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
318586011132	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
318586011133	putative NAD(P) binding site [chemical binding]; other site
318586011134	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
318586011135	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
318586011136	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
318586011137	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
318586011138	B12 binding site [chemical binding]; other site
318586011139	cobalt ligand [ion binding]; other site
318586011140	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
318586011141	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
318586011142	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
318586011143	signal recognition particle protein; Provisional; Region: PRK10867
318586011144	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
318586011145	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
318586011146	P loop; other site
318586011147	GTP binding site [chemical binding]; other site
318586011148	Signal peptide binding domain; Region: SRP_SPB; pfam02978
318586011149	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
318586011150	chorismate mutase; Provisional; Region: PRK09239
318586011151	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
318586011152	RimM N-terminal domain; Region: RimM; pfam01782
318586011153	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
318586011154	PRC-barrel domain; Region: PRC; pfam05239
318586011155	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
318586011156	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
318586011157	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
318586011158	ATPase MipZ; Region: MipZ; pfam09140
318586011159	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586011160	P-loop; other site
318586011161	Magnesium ion binding site [ion binding]; other site
318586011162	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586011163	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586011164	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
318586011165	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
318586011166	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586011167	E3 interaction surface; other site
318586011168	lipoyl attachment site [posttranslational modification]; other site
318586011169	e3 binding domain; Region: E3_binding; pfam02817
318586011170	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
318586011171	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
318586011172	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586011173	E3 interaction surface; other site
318586011174	lipoyl attachment site [posttranslational modification]; other site
318586011175	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
318586011176	alpha subunit interface [polypeptide binding]; other site
318586011177	TPP binding site [chemical binding]; other site
318586011178	heterodimer interface [polypeptide binding]; other site
318586011179	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586011180	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
318586011181	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
318586011182	tetramer interface [polypeptide binding]; other site
318586011183	TPP-binding site [chemical binding]; other site
318586011184	heterodimer interface [polypeptide binding]; other site
318586011185	phosphorylation loop region [posttranslational modification]
318586011186	Septum formation initiator; Region: DivIC; cl17659
318586011187	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013
318586011188	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
318586011189	metal binding site [ion binding]; metal-binding site
318586011190	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
318586011191	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
318586011192	intersubunit interface [polypeptide binding]; other site
318586011193	active site
318586011194	catalytic residue [active]
318586011195	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586011196	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586011197	NAD(P) binding site [chemical binding]; other site
318586011198	catalytic residues [active]
318586011199	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586011200	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
318586011201	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
318586011202	MoxR-like ATPases [General function prediction only]; Region: COG0714
318586011203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011204	Walker A motif; other site
318586011205	ATP binding site [chemical binding]; other site
318586011206	Walker B motif; other site
318586011207	arginine finger; other site
318586011208	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
318586011209	Protein of unknown function DUF58; Region: DUF58; pfam01882
318586011210	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
318586011211	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
318586011212	CARDB; Region: CARDB; pfam07705
318586011213	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
318586011214	Filamin/ABP280 repeat; Region: Filamin; pfam00630
318586011215	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
318586011216	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
318586011217	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
318586011218	active site
318586011219	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
318586011220	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
318586011221	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
318586011222	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
318586011223	homotrimer interaction site [polypeptide binding]; other site
318586011224	putative active site [active]
318586011225	hypothetical protein; Provisional; Region: PRK10621
318586011226	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586011227	Methyltransferase domain; Region: Methyltransf_23; pfam13489
318586011228	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586011229	S-adenosylmethionine binding site [chemical binding]; other site
318586011230	Predicted membrane protein [Function unknown]; Region: COG3748
318586011231	Protein of unknown function (DUF989); Region: DUF989; pfam06181
318586011232	Cytochrome c; Region: Cytochrom_C; pfam00034
318586011233	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
318586011234	active site
318586011235	homotetramer interface [polypeptide binding]; other site
318586011236	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
318586011237	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
318586011238	active site
318586011239	putative substrate binding pocket [chemical binding]; other site
318586011240	xanthine permease; Region: pbuX; TIGR03173
318586011241	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
318586011242	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
318586011243	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
318586011244	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
318586011245	dimer interface [polypeptide binding]; other site
318586011246	active site
318586011247	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
318586011248	substrate binding site [chemical binding]; other site
318586011249	catalytic residue [active]
318586011250	serine racemase; Region: PLN02970
318586011251	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
318586011252	tetramer interface [polypeptide binding]; other site
318586011253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586011254	catalytic residue [active]
318586011255	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
318586011256	homodimer interface [polypeptide binding]; other site
318586011257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586011258	catalytic residue [active]
318586011259	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586011260	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
318586011261	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586011262	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
318586011263	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
318586011264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
318586011265	TPR motif; other site
318586011266	binding surface
318586011267	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
318586011268	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
318586011269	dimerization interface [polypeptide binding]; other site
318586011270	putative ATP binding site [chemical binding]; other site
318586011271	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
318586011272	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
318586011273	active site
318586011274	substrate binding site [chemical binding]; other site
318586011275	cosubstrate binding site; other site
318586011276	catalytic site [active]
318586011277	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586011278	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586011279	TM-ABC transporter signature motif; other site
318586011280	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586011281	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586011282	TM-ABC transporter signature motif; other site
318586011283	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586011284	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586011285	Walker A/P-loop; other site
318586011286	ATP binding site [chemical binding]; other site
318586011287	Q-loop/lid; other site
318586011288	ABC transporter signature motif; other site
318586011289	Walker B; other site
318586011290	D-loop; other site
318586011291	H-loop/switch region; other site
318586011292	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586011293	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586011294	Walker A/P-loop; other site
318586011295	ATP binding site [chemical binding]; other site
318586011296	Q-loop/lid; other site
318586011297	ABC transporter signature motif; other site
318586011298	Walker B; other site
318586011299	D-loop; other site
318586011300	H-loop/switch region; other site
318586011301	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
318586011302	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
318586011303	putative ligand binding site [chemical binding]; other site
318586011304	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586011305	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
318586011306	conserved cys residue [active]
318586011307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586011308	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586011309	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
318586011310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
318586011311	PAS domain; Region: PAS_5; pfam07310
318586011312	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
318586011313	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
318586011314	catalytic site [active]
318586011315	G-X2-G-X-G-K; other site
318586011316	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
318586011317	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
318586011318	trimer interface [polypeptide binding]; other site
318586011319	putative metal binding site [ion binding]; other site
318586011320	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
318586011321	PAS domain; Region: PAS; smart00091
318586011322	putative active site [active]
318586011323	heme pocket [chemical binding]; other site
318586011324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586011325	dimer interface [polypeptide binding]; other site
318586011326	phosphorylation site [posttranslational modification]
318586011327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586011328	ATP binding site [chemical binding]; other site
318586011329	Mg2+ binding site [ion binding]; other site
318586011330	G-X-G motif; other site
318586011331	amidophosphoribosyltransferase; Provisional; Region: PRK09123
318586011332	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
318586011333	active site
318586011334	tetramer interface [polypeptide binding]; other site
318586011335	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586011336	active site
318586011337	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
318586011338	Colicin V production protein; Region: Colicin_V; pfam02674
318586011339	DNA repair protein RadA; Provisional; Region: PRK11823
318586011340	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
318586011341	Walker A motif; other site
318586011342	ATP binding site [chemical binding]; other site
318586011343	Walker B motif; other site
318586011344	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
318586011345	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
318586011346	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
318586011347	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
318586011348	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
318586011349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586011350	Transcriptional regulators [Transcription]; Region: FadR; COG2186
318586011351	DNA-binding site [nucleotide binding]; DNA binding site
318586011352	FCD domain; Region: FCD; pfam07729
318586011353	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
318586011354	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
318586011355	helix-hairpin-helix signature motif; other site
318586011356	putative hydrolase; Provisional; Region: PRK11460
318586011357	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
318586011358	putative metal binding site [ion binding]; other site
318586011359	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586011360	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
318586011361	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
318586011362	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
318586011363	active site
318586011364	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
318586011365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586011366	FeS/SAM binding site; other site
318586011367	methionine synthase I; Validated; Region: PRK07534
318586011368	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
318586011369	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
318586011370	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
318586011371	active site
318586011372	HIGH motif; other site
318586011373	dimer interface [polypeptide binding]; other site
318586011374	KMSKS motif; other site
318586011375	Rhomboid family; Region: Rhomboid; pfam01694
318586011376	integral membrane protein MviN; Region: mviN; TIGR01695
318586011377	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
318586011378	PII uridylyl-transferase; Provisional; Region: PRK05092
318586011379	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
318586011380	metal binding triad; other site
318586011381	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
318586011382	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
318586011383	Zn2+ binding site [ion binding]; other site
318586011384	Mg2+ binding site [ion binding]; other site
318586011385	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
318586011386	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
318586011387	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586011388	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
318586011389	putative ligand binding site [chemical binding]; other site
318586011390	Predicted methyltransferases [General function prediction only]; Region: COG0313
318586011391	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
318586011392	putative SAM binding site [chemical binding]; other site
318586011393	putative homodimer interface [polypeptide binding]; other site
318586011394	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
318586011395	glutathione synthetase; Provisional; Region: PRK05246
318586011396	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
318586011397	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
318586011398	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
318586011399	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
318586011400	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011401	Walker A motif; other site
318586011402	ATP binding site [chemical binding]; other site
318586011403	Walker B motif; other site
318586011404	arginine finger; other site
318586011405	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
318586011406	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
318586011407	Flavoprotein; Region: Flavoprotein; pfam02441
318586011408	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
318586011409	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
318586011410	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
318586011411	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586011412	catalytic residue [active]
318586011413	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
318586011414	putative ABC transporter; Region: ycf24; CHL00085
318586011415	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
318586011416	FeS assembly ATPase SufC; Region: sufC; TIGR01978
318586011417	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
318586011418	Walker A/P-loop; other site
318586011419	ATP binding site [chemical binding]; other site
318586011420	Q-loop/lid; other site
318586011421	ABC transporter signature motif; other site
318586011422	Walker B; other site
318586011423	D-loop; other site
318586011424	H-loop/switch region; other site
318586011425	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
318586011426	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
318586011427	Yip1 domain; Region: Yip1; pfam04893
318586011428	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
318586011429	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
318586011430	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
318586011431	catalytic residue [active]
318586011432	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
318586011433	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
318586011434	dimerization interface [polypeptide binding]; other site
318586011435	ATP binding site [chemical binding]; other site
318586011436	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
318586011437	dimerization interface [polypeptide binding]; other site
318586011438	ATP binding site [chemical binding]; other site
318586011439	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586011440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586011441	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
318586011442	putative effector binding pocket; other site
318586011443	dimerization interface [polypeptide binding]; other site
318586011444	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
318586011445	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
318586011446	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
318586011447	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
318586011448	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
318586011449	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
318586011450	enoyl-CoA hydratase; Provisional; Region: PRK08140
318586011451	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586011452	substrate binding site [chemical binding]; other site
318586011453	oxyanion hole (OAH) forming residues; other site
318586011454	trimer interface [polypeptide binding]; other site
318586011455	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
318586011456	Protein of unknown function (DUF983); Region: DUF983; cl02211
318586011457	response regulator PleD; Reviewed; Region: pleD; PRK09581
318586011458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586011459	active site
318586011460	phosphorylation site [posttranslational modification]
318586011461	intermolecular recognition site; other site
318586011462	dimerization interface [polypeptide binding]; other site
318586011463	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
318586011464	metal binding site [ion binding]; metal-binding site
318586011465	active site
318586011466	I-site; other site
318586011467	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
318586011468	aminotransferase; Provisional; Region: PRK06105
318586011469	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586011470	inhibitor-cofactor binding pocket; inhibition site
318586011471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586011472	catalytic residue [active]
318586011473	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
318586011474	Cytochrome P450; Region: p450; cl12078
318586011475	Peptidase family M48; Region: Peptidase_M48; cl12018
318586011476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
318586011477	exopolyphosphatase; Region: exo_poly_only; TIGR03706
318586011478	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
318586011479	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
318586011480	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
318586011481	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586011482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586011483	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
318586011484	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
318586011485	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
318586011486	putative nucleotide binding site [chemical binding]; other site
318586011487	uridine monophosphate binding site [chemical binding]; other site
318586011488	homohexameric interface [polypeptide binding]; other site
318586011489	ribosome recycling factor; Reviewed; Region: frr; PRK00083
318586011490	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
318586011491	hinge region; other site
318586011492	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
318586011493	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
318586011494	catalytic residue [active]
318586011495	putative FPP diphosphate  binding site; other site
318586011496	putative FPP binding hydrophobic cleft; other site
318586011497	dimer interface [polypeptide binding]; other site
318586011498	putative IPP diphosphate binding site; other site
318586011499	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
318586011500	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
318586011501	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
318586011502	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
318586011503	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
318586011504	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
318586011505	RIP metalloprotease RseP; Region: TIGR00054
318586011506	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
318586011507	active site
318586011508	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
318586011509	protein binding site [polypeptide binding]; other site
318586011510	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
318586011511	protein binding site [polypeptide binding]; other site
318586011512	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
318586011513	putative substrate binding region [chemical binding]; other site
318586011514	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
318586011515	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
318586011516	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
318586011517	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
318586011518	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
318586011519	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
318586011520	Surface antigen; Region: Bac_surface_Ag; pfam01103
318586011521	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
318586011522	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
318586011523	active site
318586011524	tetramer interface [polypeptide binding]; other site
318586011525	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
318586011526	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
318586011527	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
318586011528	active site
318586011529	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
318586011530	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
318586011531	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
318586011532	Protein of unknown function, DUF488; Region: DUF488; pfam04343
318586011533	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
318586011534	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586011535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586011536	HAMP domain; Region: HAMP; pfam00672
318586011537	dimerization interface [polypeptide binding]; other site
318586011538	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
318586011539	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586011540	dimer interface [polypeptide binding]; other site
318586011541	phosphorylation site [posttranslational modification]
318586011542	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586011543	ATP binding site [chemical binding]; other site
318586011544	Mg2+ binding site [ion binding]; other site
318586011545	G-X-G motif; other site
318586011546	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586011547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586011548	active site
318586011549	phosphorylation site [posttranslational modification]
318586011550	intermolecular recognition site; other site
318586011551	dimerization interface [polypeptide binding]; other site
318586011552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011553	Walker A motif; other site
318586011554	ATP binding site [chemical binding]; other site
318586011555	Walker B motif; other site
318586011556	arginine finger; other site
318586011557	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
318586011558	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
318586011559	putative molybdopterin cofactor binding site [chemical binding]; other site
318586011560	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
318586011561	putative molybdopterin cofactor binding site; other site
318586011562	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
318586011563	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
318586011564	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
318586011565	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
318586011566	Clp amino terminal domain; Region: Clp_N; pfam02861
318586011567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011568	Walker A motif; other site
318586011569	ATP binding site [chemical binding]; other site
318586011570	Walker B motif; other site
318586011571	arginine finger; other site
318586011572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011573	Walker A motif; other site
318586011574	ATP binding site [chemical binding]; other site
318586011575	Walker B motif; other site
318586011576	arginine finger; other site
318586011577	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
318586011578	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
318586011579	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
318586011580	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
318586011581	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
318586011582	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586011583	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
318586011584	putative ligand binding site [chemical binding]; other site
318586011585	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586011586	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586011587	TM-ABC transporter signature motif; other site
318586011588	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586011589	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586011590	TM-ABC transporter signature motif; other site
318586011591	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
318586011592	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586011593	Walker A/P-loop; other site
318586011594	ATP binding site [chemical binding]; other site
318586011595	Q-loop/lid; other site
318586011596	ABC transporter signature motif; other site
318586011597	Walker B; other site
318586011598	D-loop; other site
318586011599	H-loop/switch region; other site
318586011600	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
318586011601	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586011602	Walker A/P-loop; other site
318586011603	ATP binding site [chemical binding]; other site
318586011604	Q-loop/lid; other site
318586011605	ABC transporter signature motif; other site
318586011606	Walker B; other site
318586011607	D-loop; other site
318586011608	H-loop/switch region; other site
318586011609	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
318586011610	putative catalytic residue [active]
318586011611	phosphoglycolate phosphatase; Provisional; Region: PRK13222
318586011612	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
318586011613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586011614	motif II; other site
318586011615	Putative phosphatase (DUF442); Region: DUF442; cl17385
318586011616	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
318586011617	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
318586011618	G1 box; other site
318586011619	putative GEF interaction site [polypeptide binding]; other site
318586011620	GTP/Mg2+ binding site [chemical binding]; other site
318586011621	Switch I region; other site
318586011622	G2 box; other site
318586011623	G3 box; other site
318586011624	Switch II region; other site
318586011625	G4 box; other site
318586011626	G5 box; other site
318586011627	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
318586011628	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
318586011629	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
318586011630	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586011631	catalytic loop [active]
318586011632	iron binding site [ion binding]; other site
318586011633	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
318586011634	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
318586011635	generic binding surface I; other site
318586011636	generic binding surface II; other site
318586011637	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
318586011638	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
318586011639	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
318586011640	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
318586011641	2-isopropylmalate synthase; Validated; Region: PRK00915
318586011642	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
318586011643	active site
318586011644	catalytic residues [active]
318586011645	metal binding site [ion binding]; metal-binding site
318586011646	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
318586011647	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
318586011648	rod shape-determining protein MreB; Provisional; Region: PRK13927
318586011649	MreB and similar proteins; Region: MreB_like; cd10225
318586011650	nucleotide binding site [chemical binding]; other site
318586011651	Mg binding site [ion binding]; other site
318586011652	putative protofilament interaction site [polypeptide binding]; other site
318586011653	RodZ interaction site [polypeptide binding]; other site
318586011654	rod shape-determining protein MreC; Provisional; Region: PRK13922
318586011655	rod shape-determining protein MreC; Region: MreC; pfam04085
318586011656	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
318586011657	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
318586011658	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
318586011659	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
318586011660	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
318586011661	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
318586011662	putative ligand binding site [chemical binding]; other site
318586011663	NAD binding site [chemical binding]; other site
318586011664	dimerization interface [polypeptide binding]; other site
318586011665	catalytic site [active]
318586011666	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
318586011667	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
318586011668	Substrate binding site; other site
318586011669	Cupin domain; Region: Cupin_2; cl17218
318586011670	NMT1/THI5 like; Region: NMT1; pfam09084
318586011671	Uncharacterized conserved protein [Function unknown]; Region: COG1284
318586011672	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
318586011673	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
318586011674	ArsC family; Region: ArsC; pfam03960
318586011675	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
318586011676	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
318586011677	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586011678	NnrS protein; Region: NnrS; pfam05940
318586011679	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
318586011680	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
318586011681	Chromate transporter; Region: Chromate_transp; pfam02417
318586011682	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
318586011683	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
318586011684	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
318586011685	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
318586011686	ligand binding site [chemical binding]; other site
318586011687	homodimer interface [polypeptide binding]; other site
318586011688	NAD(P) binding site [chemical binding]; other site
318586011689	trimer interface B [polypeptide binding]; other site
318586011690	trimer interface A [polypeptide binding]; other site
318586011691	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
318586011692	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
318586011693	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
318586011694	malate synthase G; Provisional; Region: PRK02999
318586011695	active site
318586011696	aminopeptidase N; Provisional; Region: pepN; PRK14015
318586011697	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
318586011698	Zn binding site [ion binding]; other site
318586011699	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
318586011700	putative acyl-acceptor binding pocket; other site
318586011701	gamma-glutamyl kinase; Provisional; Region: PRK05429
318586011702	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
318586011703	nucleotide binding site [chemical binding]; other site
318586011704	homotetrameric interface [polypeptide binding]; other site
318586011705	putative phosphate binding site [ion binding]; other site
318586011706	putative allosteric binding site; other site
318586011707	PUA domain; Region: PUA; pfam01472
318586011708	GTPase CgtA; Reviewed; Region: obgE; PRK12299
318586011709	GTP1/OBG; Region: GTP1_OBG; pfam01018
318586011710	Obg GTPase; Region: Obg; cd01898
318586011711	G1 box; other site
318586011712	GTP/Mg2+ binding site [chemical binding]; other site
318586011713	Switch I region; other site
318586011714	G2 box; other site
318586011715	G3 box; other site
318586011716	Switch II region; other site
318586011717	G4 box; other site
318586011718	G5 box; other site
318586011719	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
318586011720	Uncharacterized conserved protein [Function unknown]; Region: COG0397
318586011721	hypothetical protein; Validated; Region: PRK00029
318586011722	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
318586011723	putative catalytic site [active]
318586011724	putative metal binding site [ion binding]; other site
318586011725	putative phosphate binding site [ion binding]; other site
318586011726	enolase; Provisional; Region: eno; PRK00077
318586011727	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
318586011728	dimer interface [polypeptide binding]; other site
318586011729	metal binding site [ion binding]; metal-binding site
318586011730	substrate binding pocket [chemical binding]; other site
318586011731	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
318586011732	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
318586011733	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
318586011734	active site
318586011735	catalytic residues [active]
318586011736	metal binding site [ion binding]; metal-binding site
318586011737	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
318586011738	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
318586011739	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586011740	active site
318586011741	HIGH motif; other site
318586011742	nucleotide binding site [chemical binding]; other site
318586011743	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
318586011744	KMSKS motif; other site
318586011745	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
318586011746	Protein of unknown function (DUF419); Region: DUF419; pfam04237
318586011747	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586011748	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586011749	Walker A/P-loop; other site
318586011750	ATP binding site [chemical binding]; other site
318586011751	Q-loop/lid; other site
318586011752	ABC transporter signature motif; other site
318586011753	Walker B; other site
318586011754	D-loop; other site
318586011755	H-loop/switch region; other site
318586011756	TOBE domain; Region: TOBE_2; pfam08402
318586011757	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586011758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586011759	dimer interface [polypeptide binding]; other site
318586011760	conserved gate region; other site
318586011761	putative PBP binding loops; other site
318586011762	ABC-ATPase subunit interface; other site
318586011763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
318586011764	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586011765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586011766	putative PBP binding loops; other site
318586011767	dimer interface [polypeptide binding]; other site
318586011768	ABC-ATPase subunit interface; other site
318586011769	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
318586011770	RmuC family; Region: RmuC; pfam02646
318586011771	Predicted flavoprotein [General function prediction only]; Region: COG0431
318586011772	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586011773	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
318586011774	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
318586011775	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
318586011776	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
318586011777	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586011778	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
318586011779	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586011780	DNA binding residues [nucleotide binding]
318586011781	DNA primase, catalytic core; Region: dnaG; TIGR01391
318586011782	CHC2 zinc finger; Region: zf-CHC2; cl17510
318586011783	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
318586011784	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
318586011785	active site
318586011786	metal binding site [ion binding]; metal-binding site
318586011787	interdomain interaction site; other site
318586011788	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
318586011789	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586011790	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586011791	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
318586011792	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
318586011793	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586011794	phosphate binding site [ion binding]; other site
318586011795	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
318586011796	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
318586011797	5S rRNA interface [nucleotide binding]; other site
318586011798	CTC domain interface [polypeptide binding]; other site
318586011799	L16 interface [polypeptide binding]; other site
318586011800	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
318586011801	Glucose inhibited division protein A; Region: GIDA; pfam01134
318586011802	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586011803	active site
318586011804	HIGH motif; other site
318586011805	nucleotide binding site [chemical binding]; other site
318586011806	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
318586011807	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
318586011808	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
318586011809	trimerization site [polypeptide binding]; other site
318586011810	active site
318586011811	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
318586011812	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
318586011813	generic binding surface II; other site
318586011814	ssDNA binding site; other site
318586011815	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
318586011816	ATP binding site [chemical binding]; other site
318586011817	putative Mg++ binding site [ion binding]; other site
318586011818	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586011819	nucleotide binding region [chemical binding]; other site
318586011820	ATP-binding site [chemical binding]; other site
318586011821	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
318586011822	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
318586011823	nucleotide binding pocket [chemical binding]; other site
318586011824	K-X-D-G motif; other site
318586011825	catalytic site [active]
318586011826	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
318586011827	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
318586011828	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
318586011829	Dimer interface [polypeptide binding]; other site
318586011830	BRCT sequence motif; other site
318586011831	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
318586011832	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
318586011833	DNA binding site [nucleotide binding]
318586011834	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
318586011835	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
318586011836	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
318586011837	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
318586011838	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
318586011839	active site
318586011840	metal binding site [ion binding]; metal-binding site
318586011841	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
318586011842	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
318586011843	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586011844	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
318586011845	active site
318586011846	DNA binding site [nucleotide binding]
318586011847	Int/Topo IB signature motif; other site
318586011848	Response regulator receiver domain; Region: Response_reg; pfam00072
318586011849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586011850	active site
318586011851	phosphorylation site [posttranslational modification]
318586011852	intermolecular recognition site; other site
318586011853	dimerization interface [polypeptide binding]; other site
318586011854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
318586011855	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
318586011856	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
318586011857	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
318586011858	Ligand Binding Site [chemical binding]; other site
318586011859	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
318586011860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
318586011861	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
318586011862	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
318586011863	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
318586011864	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
318586011865	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586011866	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586011867	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
318586011868	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
318586011869	active site
318586011870	non-prolyl cis peptide bond; other site
318586011871	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586011872	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
318586011873	Walker A/P-loop; other site
318586011874	ATP binding site [chemical binding]; other site
318586011875	Q-loop/lid; other site
318586011876	ABC transporter signature motif; other site
318586011877	Walker B; other site
318586011878	D-loop; other site
318586011879	H-loop/switch region; other site
318586011880	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586011881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586011882	dimer interface [polypeptide binding]; other site
318586011883	conserved gate region; other site
318586011884	putative PBP binding loops; other site
318586011885	ABC-ATPase subunit interface; other site
318586011886	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
318586011887	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
318586011888	Uncharacterized conserved protein [Function unknown]; Region: COG3777
318586011889	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586011890	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
318586011891	active site 2 [active]
318586011892	active site 1 [active]
318586011893	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586011894	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586011895	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
318586011896	dimer interface [polypeptide binding]; other site
318586011897	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586011898	metal binding site [ion binding]; metal-binding site
318586011899	Methyltransferase domain; Region: Methyltransf_23; pfam13489
318586011900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586011901	S-adenosylmethionine binding site [chemical binding]; other site
318586011902	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
318586011903	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586011904	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
318586011905	putative dimerization interface [polypeptide binding]; other site
318586011906	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
318586011907	Fumarase C-terminus; Region: Fumerase_C; pfam05683
318586011908	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
318586011909	DctM-like transporters; Region: DctM; pfam06808
318586011910	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586011911	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586011912	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586011913	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
318586011914	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
318586011915	HflX GTPase family; Region: HflX; cd01878
318586011916	G1 box; other site
318586011917	GTP/Mg2+ binding site [chemical binding]; other site
318586011918	Switch I region; other site
318586011919	G2 box; other site
318586011920	G3 box; other site
318586011921	Switch II region; other site
318586011922	G4 box; other site
318586011923	G5 box; other site
318586011924	bacterial Hfq-like; Region: Hfq; cd01716
318586011925	hexamer interface [polypeptide binding]; other site
318586011926	Sm1 motif; other site
318586011927	RNA binding site [nucleotide binding]; other site
318586011928	Sm2 motif; other site
318586011929	Cation transport protein; Region: TrkH; cl17365
318586011930	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
318586011931	TrkA-N domain; Region: TrkA_N; pfam02254
318586011932	TrkA-C domain; Region: TrkA_C; pfam02080
318586011933	TrkA-N domain; Region: TrkA_N; pfam02254
318586011934	TrkA-C domain; Region: TrkA_C; pfam02080
318586011935	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586011936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586011937	active site
318586011938	phosphorylation site [posttranslational modification]
318586011939	intermolecular recognition site; other site
318586011940	dimerization interface [polypeptide binding]; other site
318586011941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011942	Walker A motif; other site
318586011943	ATP binding site [chemical binding]; other site
318586011944	Walker B motif; other site
318586011945	arginine finger; other site
318586011946	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
318586011947	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
318586011948	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
318586011949	dimerization interface [polypeptide binding]; other site
318586011950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
318586011951	putative active site [active]
318586011952	heme pocket [chemical binding]; other site
318586011953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586011954	dimer interface [polypeptide binding]; other site
318586011955	phosphorylation site [posttranslational modification]
318586011956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586011957	ATP binding site [chemical binding]; other site
318586011958	Mg2+ binding site [ion binding]; other site
318586011959	G-X-G motif; other site
318586011960	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586011961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586011962	active site
318586011963	phosphorylation site [posttranslational modification]
318586011964	intermolecular recognition site; other site
318586011965	dimerization interface [polypeptide binding]; other site
318586011966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586011967	Walker A motif; other site
318586011968	ATP binding site [chemical binding]; other site
318586011969	Walker B motif; other site
318586011970	arginine finger; other site
318586011971	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
318586011972	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
318586011973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586011974	dimer interface [polypeptide binding]; other site
318586011975	phosphorylation site [posttranslational modification]
318586011976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586011977	ATP binding site [chemical binding]; other site
318586011978	Mg2+ binding site [ion binding]; other site
318586011979	G-X-G motif; other site
318586011980	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
318586011981	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
318586011982	FMN binding site [chemical binding]; other site
318586011983	active site
318586011984	catalytic residues [active]
318586011985	substrate binding site [chemical binding]; other site
318586011986	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
318586011987	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
318586011988	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
318586011989	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
318586011990	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
318586011991	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586011992	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
318586011993	ABC-ATPase subunit  interface; other site
318586011994	dimer interface [polypeptide binding]; other site
318586011995	putative PBP binding regions; other site
318586011996	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
318586011997	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
318586011998	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
318586011999	metal binding site 2 [ion binding]; metal-binding site
318586012000	putative DNA binding helix; other site
318586012001	metal binding site 1 [ion binding]; metal-binding site
318586012002	dimer interface [polypeptide binding]; other site
318586012003	structural Zn2+ binding site [ion binding]; other site
318586012004	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
318586012005	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
318586012006	metal binding site [ion binding]; metal-binding site
318586012007	Hemin uptake protein hemP; Region: hemP; pfam10636
318586012008	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
318586012009	RNA binding surface [nucleotide binding]; other site
318586012010	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
318586012011	pseudouridine synthase; Region: TIGR00093
318586012012	active site
318586012013	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
318586012014	nucleoside/Zn binding site; other site
318586012015	dimer interface [polypeptide binding]; other site
318586012016	catalytic motif [active]
318586012017	pyruvate carboxylase; Reviewed; Region: PRK12999
318586012018	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
318586012019	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586012020	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
318586012021	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
318586012022	active site
318586012023	catalytic residues [active]
318586012024	metal binding site [ion binding]; metal-binding site
318586012025	homodimer binding site [polypeptide binding]; other site
318586012026	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
318586012027	carboxyltransferase (CT) interaction site; other site
318586012028	biotinylation site [posttranslational modification]; other site
318586012029	Sulphur transport; Region: Sulf_transp; pfam04143
318586012030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586012031	dimerization interface [polypeptide binding]; other site
318586012032	putative DNA binding site [nucleotide binding]; other site
318586012033	putative Zn2+ binding site [ion binding]; other site
318586012034	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
318586012035	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
318586012036	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
318586012037	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
318586012038	catalytic residues [active]
318586012039	Cytochrome c; Region: Cytochrom_C; pfam00034
318586012040	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
318586012041	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
318586012042	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
318586012043	Cytochrome c [Energy production and conversion]; Region: COG3258
318586012044	Cytochrome c [Energy production and conversion]; Region: COG3258
318586012045	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
318586012046	active site
318586012047	metal binding site [ion binding]; metal-binding site
318586012048	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
318586012049	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
318586012050	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
318586012051	Moco binding site; other site
318586012052	metal coordination site [ion binding]; other site
318586012053	Cytochrome c; Region: Cytochrom_C; pfam00034
318586012054	Cytochrome c2 [Energy production and conversion]; Region: COG3474
318586012055	Cytochrome c2 [Energy production and conversion]; Region: COG3474
318586012056	Cytochrome c; Region: Cytochrom_C; cl11414
318586012057	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
318586012058	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586012059	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
318586012060	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586012061	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
318586012062	Sulphur transport; Region: Sulf_transp; pfam04143
318586012063	active site
318586012064	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
318586012065	Predicted transcriptional regulators [Transcription]; Region: COG1733
318586012066	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
318586012067	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
318586012068	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586012069	NnrS protein; Region: NnrS; pfam05940
318586012070	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586012071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586012072	Walker A/P-loop; other site
318586012073	ATP binding site [chemical binding]; other site
318586012074	Q-loop/lid; other site
318586012075	ABC transporter signature motif; other site
318586012076	Walker B; other site
318586012077	D-loop; other site
318586012078	H-loop/switch region; other site
318586012079	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586012080	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
318586012081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586012082	substrate binding pocket [chemical binding]; other site
318586012083	membrane-bound complex binding site; other site
318586012084	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
318586012085	Transcriptional regulator; Region: Rrf2; cl17282
318586012086	Rrf2 family protein; Region: rrf2_super; TIGR00738
318586012087	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
318586012088	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586012089	N-terminal plug; other site
318586012090	ligand-binding site [chemical binding]; other site
318586012091	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
318586012092	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
318586012093	DNA binding residues [nucleotide binding]
318586012094	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
318586012095	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
318586012096	nucleotide binding site [chemical binding]; other site
318586012097	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
318586012098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
318586012099	motif II; other site
318586012100	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
318586012101	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
318586012102	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
318586012103	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
318586012104	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586012105	Walker A/P-loop; other site
318586012106	ATP binding site [chemical binding]; other site
318586012107	Q-loop/lid; other site
318586012108	ABC transporter signature motif; other site
318586012109	Walker B; other site
318586012110	D-loop; other site
318586012111	H-loop/switch region; other site
318586012112	TOBE domain; Region: TOBE_2; pfam08402
318586012113	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586012114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012115	dimer interface [polypeptide binding]; other site
318586012116	conserved gate region; other site
318586012117	putative PBP binding loops; other site
318586012118	ABC-ATPase subunit interface; other site
318586012119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
318586012120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012121	conserved gate region; other site
318586012122	putative PBP binding loops; other site
318586012123	ABC-ATPase subunit interface; other site
318586012124	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586012125	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586012126	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
318586012127	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
318586012128	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
318586012129	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
318586012130	active site
318586012131	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
318586012132	Ligand Binding Site [chemical binding]; other site
318586012133	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
318586012134	nucleotide binding site [chemical binding]; other site
318586012135	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
318586012136	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586012137	Walker A/P-loop; other site
318586012138	ATP binding site [chemical binding]; other site
318586012139	Q-loop/lid; other site
318586012140	ABC transporter signature motif; other site
318586012141	Walker B; other site
318586012142	D-loop; other site
318586012143	H-loop/switch region; other site
318586012144	TOBE domain; Region: TOBE_2; pfam08402
318586012145	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586012146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012147	dimer interface [polypeptide binding]; other site
318586012148	conserved gate region; other site
318586012149	putative PBP binding loops; other site
318586012150	ABC-ATPase subunit interface; other site
318586012151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012152	dimer interface [polypeptide binding]; other site
318586012153	conserved gate region; other site
318586012154	putative PBP binding loops; other site
318586012155	ABC-ATPase subunit interface; other site
318586012156	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586012157	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586012158	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
318586012159	heme binding site [chemical binding]; other site
318586012160	substrate binding site [chemical binding]; other site
318586012161	Bacterial transcriptional activator domain; Region: BTAD; smart01043
318586012162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
318586012163	TPR motif; other site
318586012164	binding surface
318586012165	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
318586012166	NADPH bind site [chemical binding]; other site
318586012167	putative FMN binding site [chemical binding]; other site
318586012168	YcaO-like family; Region: YcaO; pfam02624
318586012169	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
318586012170	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
318586012171	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
318586012172	ATP binding site [chemical binding]; other site
318586012173	substrate interface [chemical binding]; other site
318586012174	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
318586012175	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
318586012176	B12 binding site [chemical binding]; other site
318586012177	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586012178	FeS/SAM binding site; other site
318586012179	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
318586012180	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586012181	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
318586012182	Walker A/P-loop; other site
318586012183	ATP binding site [chemical binding]; other site
318586012184	Q-loop/lid; other site
318586012185	ABC transporter signature motif; other site
318586012186	Walker B; other site
318586012187	D-loop; other site
318586012188	H-loop/switch region; other site
318586012189	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
318586012190	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586012191	N-terminal plug; other site
318586012192	ligand-binding site [chemical binding]; other site
318586012193	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
318586012194	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
318586012195	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
318586012196	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586012197	intersubunit interface [polypeptide binding]; other site
318586012198	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586012199	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586012200	ABC-ATPase subunit  interface; other site
318586012201	dimer interface [polypeptide binding]; other site
318586012202	putative PBP binding regions; other site
318586012203	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
318586012204	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586012205	Walker A/P-loop; other site
318586012206	ATP binding site [chemical binding]; other site
318586012207	Q-loop/lid; other site
318586012208	ABC transporter signature motif; other site
318586012209	Walker B; other site
318586012210	D-loop; other site
318586012211	H-loop/switch region; other site
318586012212	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
318586012213	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
318586012214	putative NAD(P) binding site [chemical binding]; other site
318586012215	putative substrate binding site [chemical binding]; other site
318586012216	catalytic Zn binding site [ion binding]; other site
318586012217	structural Zn binding site [ion binding]; other site
318586012218	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
318586012219	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
318586012220	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
318586012221	Acetokinase family; Region: Acetate_kinase; cl17229
318586012222	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
318586012223	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
318586012224	Response regulator receiver domain; Region: Response_reg; pfam00072
318586012225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586012226	active site
318586012227	phosphorylation site [posttranslational modification]
318586012228	intermolecular recognition site; other site
318586012229	dimerization interface [polypeptide binding]; other site
318586012230	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
318586012231	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
318586012232	Na binding site [ion binding]; other site
318586012233	Protein of unknown function, DUF485; Region: DUF485; pfam04341
318586012234	acetyl-CoA synthetase; Provisional; Region: PRK00174
318586012235	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
318586012236	active site
318586012237	CoA binding site [chemical binding]; other site
318586012238	acyl-activating enzyme (AAE) consensus motif; other site
318586012239	AMP binding site [chemical binding]; other site
318586012240	acetate binding site [chemical binding]; other site
318586012241	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
318586012242	ApbE family; Region: ApbE; pfam02424
318586012243	NosL; Region: NosL; pfam05573
318586012244	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
318586012245	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
318586012246	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
318586012247	Walker A/P-loop; other site
318586012248	ATP binding site [chemical binding]; other site
318586012249	Q-loop/lid; other site
318586012250	ABC transporter signature motif; other site
318586012251	Walker B; other site
318586012252	D-loop; other site
318586012253	H-loop/switch region; other site
318586012254	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
318586012255	nitrous-oxide reductase; Validated; Region: PRK02888
318586012256	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
318586012257	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
318586012258	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
318586012259	4Fe-4S binding domain; Region: Fer4_5; pfam12801
318586012260	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
318586012261	pseudoazurin; Region: pseudoazurin; TIGR02375
318586012262	Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846
318586012263	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
318586012264	Hemerythrin-like domain; Region: Hr-like; cd12108
318586012265	Fe binding site [ion binding]; other site
318586012266	Flavoprotein; Region: Flavoprotein; pfam02441
318586012267	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
318586012268	SCP-2 sterol transfer family; Region: SCP2; cl01225
318586012269	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
318586012270	Peptidase family U32; Region: Peptidase_U32; pfam01136
318586012271	putative protease; Provisional; Region: PRK15447
318586012272	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
318586012273	NnrS protein; Region: NnrS; pfam05940
318586012274	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
318586012275	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
318586012276	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
318586012277	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
318586012278	nitrate reductase, beta subunit; Region: narH; TIGR01660
318586012279	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
318586012280	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
318586012281	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
318586012282	[4Fe-4S] binding site [ion binding]; other site
318586012283	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
318586012284	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
318586012285	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
318586012286	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
318586012287	molybdopterin cofactor binding site; other site
318586012288	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
318586012289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586012290	putative substrate translocation pore; other site
318586012291	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
318586012292	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
318586012293	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
318586012294	ligand binding site [chemical binding]; other site
318586012295	flexible hinge region; other site
318586012296	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
318586012297	putative switch regulator; other site
318586012298	non-specific DNA interactions [nucleotide binding]; other site
318586012299	DNA binding site [nucleotide binding]
318586012300	sequence specific DNA binding site [nucleotide binding]; other site
318586012301	putative cAMP binding site [chemical binding]; other site
318586012302	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
318586012303	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
318586012304	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586012305	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
318586012306	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
318586012307	DNA binding site [nucleotide binding]
318586012308	active site
318586012309	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
318586012310	FAD binding pocket [chemical binding]; other site
318586012311	FAD binding motif [chemical binding]; other site
318586012312	phosphate binding motif [ion binding]; other site
318586012313	NAD binding pocket [chemical binding]; other site
318586012314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586012315	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
318586012316	putative substrate translocation pore; other site
318586012317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
318586012318	Transcriptional regulators [Transcription]; Region: FadR; COG2186
318586012319	FCD domain; Region: FCD; pfam07729
318586012320	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
318586012321	active site
318586012322	homotetramer interface [polypeptide binding]; other site
318586012323	homodimer interface [polypeptide binding]; other site
318586012324	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586012325	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586012326	dihydroxy-acid dehydratase; Validated; Region: PRK06131
318586012327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
318586012328	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
318586012329	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586012330	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012331	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586012332	dimerization interface [polypeptide binding]; other site
318586012333	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
318586012334	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
318586012335	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
318586012336	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
318586012337	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
318586012338	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
318586012339	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
318586012340	nucleoside/Zn binding site; other site
318586012341	dimer interface [polypeptide binding]; other site
318586012342	catalytic motif [active]
318586012343	putative cyanate transporter; Provisional; Region: cynX; PRK09705
318586012344	Domain of unknown function (DUF336); Region: DUF336; pfam03928
318586012345	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
318586012346	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
318586012347	nucleotide binding site [chemical binding]; other site
318586012348	putative NEF/HSP70 interaction site [polypeptide binding]; other site
318586012349	SBD interface [polypeptide binding]; other site
318586012350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586012351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012352	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
318586012353	putative effector binding pocket; other site
318586012354	dimerization interface [polypeptide binding]; other site
318586012355	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
318586012356	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586012357	catalytic loop [active]
318586012358	iron binding site [ion binding]; other site
318586012359	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
318586012360	FAD binding domain; Region: FAD_binding_4; pfam01565
318586012361	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
318586012362	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
318586012363	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
318586012364	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
318586012365	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
318586012366	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
318586012367	XdhC Rossmann domain; Region: XdhC_C; pfam13478
318586012368	guanine deaminase; Provisional; Region: PRK09228
318586012369	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
318586012370	active site
318586012371	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
318586012372	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
318586012373	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
318586012374	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
318586012375	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
318586012376	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
318586012377	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
318586012378	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
318586012379	GAF domain; Region: GAF; pfam01590
318586012380	Reversibly glycosylated polypeptide; Region: RGP; cl07847
318586012381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586012382	Walker A motif; other site
318586012383	ATP binding site [chemical binding]; other site
318586012384	Walker B motif; other site
318586012385	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
318586012386	Transcriptional regulators [Transcription]; Region: FadR; COG2186
318586012387	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586012388	DNA-binding site [nucleotide binding]; DNA binding site
318586012389	FCD domain; Region: FCD; pfam07729
318586012390	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
318586012391	Uncharacterized conserved protein [Function unknown]; Region: COG5476
318586012392	MlrC C-terminus; Region: MlrC_C; pfam07171
318586012393	allantoate amidohydrolase; Reviewed; Region: PRK09290
318586012394	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
318586012395	active site
318586012396	metal binding site [ion binding]; metal-binding site
318586012397	dimer interface [polypeptide binding]; other site
318586012398	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586012399	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586012400	Walker A/P-loop; other site
318586012401	ATP binding site [chemical binding]; other site
318586012402	Q-loop/lid; other site
318586012403	ABC transporter signature motif; other site
318586012404	Walker B; other site
318586012405	D-loop; other site
318586012406	H-loop/switch region; other site
318586012407	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586012408	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586012409	Walker A/P-loop; other site
318586012410	ATP binding site [chemical binding]; other site
318586012411	Q-loop/lid; other site
318586012412	ABC transporter signature motif; other site
318586012413	Walker B; other site
318586012414	D-loop; other site
318586012415	H-loop/switch region; other site
318586012416	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586012417	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586012418	TM-ABC transporter signature motif; other site
318586012419	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586012420	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586012421	TM-ABC transporter signature motif; other site
318586012422	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586012423	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
318586012424	putative ligand binding site [chemical binding]; other site
318586012425	aminotransferase; Validated; Region: PRK07678
318586012426	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586012427	inhibitor-cofactor binding pocket; inhibition site
318586012428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586012429	catalytic residue [active]
318586012430	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
318586012431	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586012432	DNA-binding site [nucleotide binding]; DNA binding site
318586012433	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586012434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586012435	homodimer interface [polypeptide binding]; other site
318586012436	catalytic residue [active]
318586012437	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; pfam01515
318586012438	Predicted membrane protein [Function unknown]; Region: COG2855
318586012439	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
318586012440	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586012441	PYR/PP interface [polypeptide binding]; other site
318586012442	dimer interface [polypeptide binding]; other site
318586012443	TPP binding site [chemical binding]; other site
318586012444	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586012445	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
318586012446	TPP-binding site [chemical binding]; other site
318586012447	choline dehydrogenase; Validated; Region: PRK02106
318586012448	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586012449	metabolite-proton symporter; Region: 2A0106; TIGR00883
318586012450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586012451	putative substrate translocation pore; other site
318586012452	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586012453	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586012454	dimerization interface [polypeptide binding]; other site
318586012455	putative Zn2+ binding site [ion binding]; other site
318586012456	putative DNA binding site [nucleotide binding]; other site
318586012457	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586012458	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
318586012459	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586012460	Walker A/P-loop; other site
318586012461	ATP binding site [chemical binding]; other site
318586012462	Q-loop/lid; other site
318586012463	ABC transporter signature motif; other site
318586012464	Walker B; other site
318586012465	D-loop; other site
318586012466	H-loop/switch region; other site
318586012467	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
318586012468	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
318586012469	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586012470	Walker A/P-loop; other site
318586012471	ATP binding site [chemical binding]; other site
318586012472	Q-loop/lid; other site
318586012473	ABC transporter signature motif; other site
318586012474	Walker B; other site
318586012475	D-loop; other site
318586012476	H-loop/switch region; other site
318586012477	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586012478	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586012479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012480	dimer interface [polypeptide binding]; other site
318586012481	conserved gate region; other site
318586012482	putative PBP binding loops; other site
318586012483	ABC-ATPase subunit interface; other site
318586012484	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586012485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012486	dimer interface [polypeptide binding]; other site
318586012487	conserved gate region; other site
318586012488	putative PBP binding loops; other site
318586012489	ABC-ATPase subunit interface; other site
318586012490	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586012491	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
318586012492	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586012493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012494	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
318586012495	putative substrate binding pocket [chemical binding]; other site
318586012496	dimerization interface [polypeptide binding]; other site
318586012497	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
318586012498	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
318586012499	active site
318586012500	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
318586012501	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
318586012502	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
318586012503	Uncharacterized conserved protein [Function unknown]; Region: COG4544
318586012504	Y-family of DNA polymerases; Region: PolY; cl12025
318586012505	DNA binding site [nucleotide binding]
318586012506	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
318586012507	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
318586012508	putative active site [active]
318586012509	putative PHP Thumb interface [polypeptide binding]; other site
318586012510	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
318586012511	generic binding surface II; other site
318586012512	generic binding surface I; other site
318586012513	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
318586012514	Predicted transcriptional regulators [Transcription]; Region: COG1733
318586012515	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
318586012516	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
318586012517	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
318586012518	NADP binding site [chemical binding]; other site
318586012519	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
318586012520	Part of AAA domain; Region: AAA_19; pfam13245
318586012521	Family description; Region: UvrD_C_2; pfam13538
318586012522	putative GTP cyclohydrolase; Provisional; Region: PRK13674
318586012523	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
318586012524	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
318586012525	homodimer interface [polypeptide binding]; other site
318586012526	substrate-cofactor binding pocket; other site
318586012527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586012528	catalytic residue [active]
318586012529	Intracellular septation protein A; Region: IspA; pfam04279
318586012530	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
318586012531	aconitate hydratase; Validated; Region: PRK09277
318586012532	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
318586012533	substrate binding site [chemical binding]; other site
318586012534	ligand binding site [chemical binding]; other site
318586012535	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
318586012536	substrate binding site [chemical binding]; other site
318586012537	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
318586012538	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
318586012539	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
318586012540	RNA binding surface [nucleotide binding]; other site
318586012541	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
318586012542	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
318586012543	triosephosphate isomerase; Provisional; Region: PRK14565
318586012544	substrate binding site [chemical binding]; other site
318586012545	dimer interface [polypeptide binding]; other site
318586012546	catalytic triad [active]
318586012547	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
318586012548	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
318586012549	Walker A/P-loop; other site
318586012550	ATP binding site [chemical binding]; other site
318586012551	Q-loop/lid; other site
318586012552	ABC transporter signature motif; other site
318586012553	Walker B; other site
318586012554	D-loop; other site
318586012555	H-loop/switch region; other site
318586012556	NIL domain; Region: NIL; pfam09383
318586012557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012558	dimer interface [polypeptide binding]; other site
318586012559	conserved gate region; other site
318586012560	ABC-ATPase subunit interface; other site
318586012561	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
318586012562	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
318586012563	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
318586012564	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
318586012565	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
318586012566	DoxX; Region: DoxX; cl17842
318586012567	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586012568	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012569	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
318586012570	putative effector binding pocket; other site
318586012571	dimerization interface [polypeptide binding]; other site
318586012572	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
318586012573	FAD binding domain; Region: FAD_binding_4; pfam01565
318586012574	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
318586012575	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
318586012576	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
318586012577	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
318586012578	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
318586012579	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
318586012580	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
318586012581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586012582	catalytic residue [active]
318586012583	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
318586012584	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
318586012585	Subunit III/VIIa interface [polypeptide binding]; other site
318586012586	Phospholipid binding site [chemical binding]; other site
318586012587	Subunit I/III interface [polypeptide binding]; other site
318586012588	Subunit III/VIb interface [polypeptide binding]; other site
318586012589	Subunit III/VIa interface; other site
318586012590	Subunit III/Vb interface [polypeptide binding]; other site
318586012591	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
318586012592	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
318586012593	UbiA prenyltransferase family; Region: UbiA; pfam01040
318586012594	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
318586012595	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
318586012596	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
318586012597	protease TldD; Provisional; Region: tldD; PRK10735
318586012598	DNA protecting protein DprA; Region: dprA; TIGR00732
318586012599	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
318586012600	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
318586012601	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
318586012602	ligand binding site [chemical binding]; other site
318586012603	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
318586012604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586012605	active site
318586012606	phosphorylation site [posttranslational modification]
318586012607	intermolecular recognition site; other site
318586012608	dimerization interface [polypeptide binding]; other site
318586012609	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
318586012610	DNA binding site [nucleotide binding]
318586012611	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
318586012612	PhoU domain; Region: PhoU; pfam01895
318586012613	PhoU domain; Region: PhoU; pfam01895
318586012614	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
318586012615	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
318586012616	Walker A/P-loop; other site
318586012617	ATP binding site [chemical binding]; other site
318586012618	Q-loop/lid; other site
318586012619	ABC transporter signature motif; other site
318586012620	Walker B; other site
318586012621	D-loop; other site
318586012622	H-loop/switch region; other site
318586012623	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
318586012624	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
318586012625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012626	dimer interface [polypeptide binding]; other site
318586012627	conserved gate region; other site
318586012628	putative PBP binding loops; other site
318586012629	ABC-ATPase subunit interface; other site
318586012630	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
318586012631	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
318586012632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012633	dimer interface [polypeptide binding]; other site
318586012634	conserved gate region; other site
318586012635	putative PBP binding loops; other site
318586012636	ABC-ATPase subunit interface; other site
318586012637	PBP superfamily domain; Region: PBP_like_2; pfam12849
318586012638	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
318586012639	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
318586012640	Tetramer interface [polypeptide binding]; other site
318586012641	active site
318586012642	FMN-binding site [chemical binding]; other site
318586012643	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
318586012644	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
318586012645	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
318586012646	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586012647	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
318586012648	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586012649	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
318586012650	Walker A/P-loop; other site
318586012651	ATP binding site [chemical binding]; other site
318586012652	Q-loop/lid; other site
318586012653	ABC transporter signature motif; other site
318586012654	Walker B; other site
318586012655	D-loop; other site
318586012656	H-loop/switch region; other site
318586012657	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586012658	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586012659	DNA binding residues [nucleotide binding]
318586012660	dimerization interface [polypeptide binding]; other site
318586012661	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586012662	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
318586012663	Walker A/P-loop; other site
318586012664	ATP binding site [chemical binding]; other site
318586012665	Q-loop/lid; other site
318586012666	ABC transporter signature motif; other site
318586012667	Walker B; other site
318586012668	D-loop; other site
318586012669	H-loop/switch region; other site
318586012670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012671	dimer interface [polypeptide binding]; other site
318586012672	conserved gate region; other site
318586012673	putative PBP binding loops; other site
318586012674	ABC-ATPase subunit interface; other site
318586012675	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
318586012676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012677	dimer interface [polypeptide binding]; other site
318586012678	conserved gate region; other site
318586012679	putative PBP binding loops; other site
318586012680	ABC-ATPase subunit interface; other site
318586012681	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
318586012682	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
318586012683	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
318586012684	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586012685	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
318586012686	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
318586012687	putative active site [active]
318586012688	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
318586012689	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
318586012690	Walker A/P-loop; other site
318586012691	ATP binding site [chemical binding]; other site
318586012692	Q-loop/lid; other site
318586012693	ABC transporter signature motif; other site
318586012694	Walker B; other site
318586012695	D-loop; other site
318586012696	H-loop/switch region; other site
318586012697	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
318586012698	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586012699	FeS/SAM binding site; other site
318586012700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586012701	dimer interface [polypeptide binding]; other site
318586012702	phosphorylation site [posttranslational modification]
318586012703	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
318586012704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586012705	ATP binding site [chemical binding]; other site
318586012706	Mg2+ binding site [ion binding]; other site
318586012707	G-X-G motif; other site
318586012708	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
318586012709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
318586012710	active site
318586012711	phosphorylation site [posttranslational modification]
318586012712	intermolecular recognition site; other site
318586012713	dimerization interface [polypeptide binding]; other site
318586012714	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586012715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586012716	active site
318586012717	phosphorylation site [posttranslational modification]
318586012718	intermolecular recognition site; other site
318586012719	dimerization interface [polypeptide binding]; other site
318586012720	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586012721	DNA binding residues [nucleotide binding]
318586012722	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
318586012723	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
318586012724	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
318586012725	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
318586012726	Na binding site [ion binding]; other site
318586012727	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
318586012728	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
318586012729	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
318586012730	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
318586012731	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
318586012732	Isochorismatase family; Region: Isochorismatase; pfam00857
318586012733	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
318586012734	catalytic triad [active]
318586012735	conserved cis-peptide bond; other site
318586012736	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012737	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
318586012738	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
318586012739	dimerization interface [polypeptide binding]; other site
318586012740	substrate binding pocket [chemical binding]; other site
318586012741	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
318586012742	Sulfatase; Region: Sulfatase; cl17466
318586012743	NMT1/THI5 like; Region: NMT1; pfam09084
318586012744	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
318586012745	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
318586012746	Walker A/P-loop; other site
318586012747	ATP binding site [chemical binding]; other site
318586012748	Q-loop/lid; other site
318586012749	ABC transporter signature motif; other site
318586012750	Walker B; other site
318586012751	D-loop; other site
318586012752	H-loop/switch region; other site
318586012753	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
318586012754	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586012755	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
318586012756	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586012757	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
318586012758	RibD C-terminal domain; Region: RibD_C; cl17279
318586012759	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
318586012760	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
318586012761	DJ-1 family protein; Region: not_thiJ; TIGR01383
318586012762	conserved cys residue [active]
318586012763	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586012764	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
318586012765	conserved cys residue [active]
318586012766	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586012767	DEAD-like helicases superfamily; Region: DEXDc; smart00487
318586012768	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
318586012769	ATP binding site [chemical binding]; other site
318586012770	putative Mg++ binding site [ion binding]; other site
318586012771	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
318586012772	nucleotide binding region [chemical binding]; other site
318586012773	ATP-binding site [chemical binding]; other site
318586012774	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
318586012775	RNA binding site [nucleotide binding]; other site
318586012776	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
318586012777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012778	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
318586012779	putative dimerization interface [polypeptide binding]; other site
318586012780	putative substrate binding pocket [chemical binding]; other site
318586012781	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
318586012782	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
318586012783	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586012784	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012785	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
318586012786	putative dimerization interface [polypeptide binding]; other site
318586012787	Predicted membrane protein [Function unknown]; Region: COG2855
318586012788	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586012789	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
318586012790	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586012791	N-terminal plug; other site
318586012792	ligand-binding site [chemical binding]; other site
318586012793	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
318586012794	catalytic residues [active]
318586012795	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
318586012796	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
318586012797	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
318586012798	Class I ribonucleotide reductase; Region: RNR_I; cd01679
318586012799	active site
318586012800	dimer interface [polypeptide binding]; other site
318586012801	catalytic residues [active]
318586012802	effector binding site; other site
318586012803	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
318586012804	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
318586012805	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
318586012806	dimer interface [polypeptide binding]; other site
318586012807	putative radical transfer pathway; other site
318586012808	diiron center [ion binding]; other site
318586012809	tyrosyl radical; other site
318586012810	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
318586012811	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
318586012812	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
318586012813	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586012814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586012815	homodimer interface [polypeptide binding]; other site
318586012816	catalytic residue [active]
318586012817	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
318586012818	transmembrane helices; other site
318586012819	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
318586012820	TrkA-C domain; Region: TrkA_C; pfam02080
318586012821	TrkA-C domain; Region: TrkA_C; pfam02080
318586012822	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
318586012823	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
318586012824	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586012825	N-terminal plug; other site
318586012826	ligand-binding site [chemical binding]; other site
318586012827	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586012828	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
318586012829	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
318586012830	intersubunit interface [polypeptide binding]; other site
318586012831	intersubunit interface [polypeptide binding]; other site
318586012832	FecCD transport family; Region: FecCD; pfam01032
318586012833	ABC-ATPase subunit  interface; other site
318586012834	dimer interface [polypeptide binding]; other site
318586012835	putative PBP binding regions; other site
318586012836	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586012837	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586012838	Walker A/P-loop; other site
318586012839	ATP binding site [chemical binding]; other site
318586012840	Q-loop/lid; other site
318586012841	ABC transporter signature motif; other site
318586012842	Walker B; other site
318586012843	D-loop; other site
318586012844	H-loop/switch region; other site
318586012845	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
318586012846	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
318586012847	N- and C-terminal domain interface [polypeptide binding]; other site
318586012848	active site
318586012849	MgATP binding site [chemical binding]; other site
318586012850	catalytic site [active]
318586012851	metal binding site [ion binding]; metal-binding site
318586012852	glycerol binding site [chemical binding]; other site
318586012853	homotetramer interface [polypeptide binding]; other site
318586012854	homodimer interface [polypeptide binding]; other site
318586012855	FBP binding site [chemical binding]; other site
318586012856	protein IIAGlc interface [polypeptide binding]; other site
318586012857	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586012858	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
318586012859	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586012860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012861	dimer interface [polypeptide binding]; other site
318586012862	conserved gate region; other site
318586012863	putative PBP binding loops; other site
318586012864	ABC-ATPase subunit interface; other site
318586012865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586012866	putative PBP binding loops; other site
318586012867	dimer interface [polypeptide binding]; other site
318586012868	ABC-ATPase subunit interface; other site
318586012869	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
318586012870	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
318586012871	Walker A/P-loop; other site
318586012872	ATP binding site [chemical binding]; other site
318586012873	Q-loop/lid; other site
318586012874	ABC transporter signature motif; other site
318586012875	Walker B; other site
318586012876	D-loop; other site
318586012877	H-loop/switch region; other site
318586012878	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
318586012879	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
318586012880	Walker A/P-loop; other site
318586012881	ATP binding site [chemical binding]; other site
318586012882	Q-loop/lid; other site
318586012883	ABC transporter signature motif; other site
318586012884	Walker B; other site
318586012885	D-loop; other site
318586012886	H-loop/switch region; other site
318586012887	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
318586012888	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
318586012889	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
318586012890	Active Sites [active]
318586012891	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
318586012892	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
318586012893	CysD dimerization site [polypeptide binding]; other site
318586012894	G1 box; other site
318586012895	putative GEF interaction site [polypeptide binding]; other site
318586012896	GTP/Mg2+ binding site [chemical binding]; other site
318586012897	Switch I region; other site
318586012898	G2 box; other site
318586012899	G3 box; other site
318586012900	Switch II region; other site
318586012901	G4 box; other site
318586012902	G5 box; other site
318586012903	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
318586012904	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
318586012905	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
318586012906	ligand-binding site [chemical binding]; other site
318586012907	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
318586012908	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
318586012909	Cysteine-rich domain; Region: CCG; pfam02754
318586012910	Cysteine-rich domain; Region: CCG; pfam02754
318586012911	FAD binding domain; Region: FAD_binding_4; pfam01565
318586012912	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
318586012913	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
318586012914	FAD binding domain; Region: FAD_binding_4; pfam01565
318586012915	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
318586012916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586012917	DNA-binding site [nucleotide binding]; DNA binding site
318586012918	FCD domain; Region: FCD; cl11656
318586012919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
318586012920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
318586012921	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
318586012922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
318586012923	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586012924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586012925	active site
318586012926	phosphorylation site [posttranslational modification]
318586012927	intermolecular recognition site; other site
318586012928	dimerization interface [polypeptide binding]; other site
318586012929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586012930	Walker A motif; other site
318586012931	ATP binding site [chemical binding]; other site
318586012932	Walker B motif; other site
318586012933	arginine finger; other site
318586012934	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
318586012935	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
318586012936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586012937	dimer interface [polypeptide binding]; other site
318586012938	phosphorylation site [posttranslational modification]
318586012939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586012940	ATP binding site [chemical binding]; other site
318586012941	Mg2+ binding site [ion binding]; other site
318586012942	G-X-G motif; other site
318586012943	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
318586012944	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
318586012945	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
318586012946	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
318586012947	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
318586012948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586012949	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586012950	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586012951	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
318586012952	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586012953	FAD binding site [chemical binding]; other site
318586012954	substrate binding pocket [chemical binding]; other site
318586012955	catalytic base [active]
318586012956	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
318586012957	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586012958	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
318586012959	dimerization interface [polypeptide binding]; other site
318586012960	substrate binding pocket [chemical binding]; other site
318586012961	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
318586012962	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586012963	inhibitor-cofactor binding pocket; inhibition site
318586012964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586012965	catalytic residue [active]
318586012966	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
318586012967	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586012968	non-specific DNA binding site [nucleotide binding]; other site
318586012969	salt bridge; other site
318586012970	sequence-specific DNA binding site [nucleotide binding]; other site
318586012971	Cupin domain; Region: Cupin_2; pfam07883
318586012972	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586012973	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
318586012974	tetramerization interface [polypeptide binding]; other site
318586012975	NAD(P) binding site [chemical binding]; other site
318586012976	catalytic residues [active]
318586012977	GTP-binding protein LepA; Provisional; Region: PRK05433
318586012978	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
318586012979	G1 box; other site
318586012980	putative GEF interaction site [polypeptide binding]; other site
318586012981	GTP/Mg2+ binding site [chemical binding]; other site
318586012982	Switch I region; other site
318586012983	G2 box; other site
318586012984	G3 box; other site
318586012985	Switch II region; other site
318586012986	G4 box; other site
318586012987	G5 box; other site
318586012988	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
318586012989	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
318586012990	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
318586012991	NAD-dependent deacetylase; Provisional; Region: PRK00481
318586012992	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
318586012993	NAD+ binding site [chemical binding]; other site
318586012994	substrate binding site [chemical binding]; other site
318586012995	Zn binding site [ion binding]; other site
318586012996	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
318586012997	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586012998	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586012999	active site
318586013000	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
318586013001	phosphoglucomutase; Region: PLN02307
318586013002	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
318586013003	active site
318586013004	substrate binding site [chemical binding]; other site
318586013005	metal binding site [ion binding]; metal-binding site
318586013006	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
318586013007	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
318586013008	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
318586013009	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
318586013010	active site
318586013011	catalytic site [active]
318586013012	glycogen synthase; Provisional; Region: glgA; PRK00654
318586013013	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
318586013014	ADP-binding pocket [chemical binding]; other site
318586013015	homodimer interface [polypeptide binding]; other site
318586013016	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
318586013017	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
318586013018	ligand binding site; other site
318586013019	oligomer interface; other site
318586013020	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
318586013021	dimer interface [polypeptide binding]; other site
318586013022	N-terminal domain interface [polypeptide binding]; other site
318586013023	sulfate 1 binding site; other site
318586013024	glycogen branching enzyme; Provisional; Region: PRK05402
318586013025	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
318586013026	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
318586013027	active site
318586013028	catalytic site [active]
318586013029	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
318586013030	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
318586013031	homodimer interface [polypeptide binding]; other site
318586013032	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
318586013033	active site pocket [active]
318586013034	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
318586013035	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
318586013036	dimerization interface [polypeptide binding]; other site
318586013037	active site
318586013038	L-aspartate oxidase; Provisional; Region: PRK07512
318586013039	L-aspartate oxidase; Provisional; Region: PRK06175
318586013040	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
318586013041	quinolinate synthetase; Provisional; Region: PRK09375
318586013042	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586013043	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586013044	putative DNA binding site [nucleotide binding]; other site
318586013045	putative Zn2+ binding site [ion binding]; other site
318586013046	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586013047	hypothetical protein; Provisional; Region: PRK07546
318586013048	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
318586013049	substrate-cofactor binding pocket; other site
318586013050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586013051	catalytic residue [active]
318586013052	aminodeoxychorismate synthase; Provisional; Region: PRK07508
318586013053	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
318586013054	chorismate binding enzyme; Region: Chorismate_bind; cl10555
318586013055	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586013056	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586013057	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
318586013058	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586013059	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586013060	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
318586013061	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
318586013062	conserved cys residue [active]
318586013063	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
318586013064	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586013065	Walker A/P-loop; other site
318586013066	ATP binding site [chemical binding]; other site
318586013067	Q-loop/lid; other site
318586013068	ABC transporter signature motif; other site
318586013069	Walker B; other site
318586013070	D-loop; other site
318586013071	H-loop/switch region; other site
318586013072	TOBE domain; Region: TOBE_2; pfam08402
318586013073	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586013074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013075	dimer interface [polypeptide binding]; other site
318586013076	conserved gate region; other site
318586013077	putative PBP binding loops; other site
318586013078	ABC-ATPase subunit interface; other site
318586013079	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586013080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013081	dimer interface [polypeptide binding]; other site
318586013082	conserved gate region; other site
318586013083	putative PBP binding loops; other site
318586013084	ABC-ATPase subunit interface; other site
318586013085	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586013086	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586013087	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
318586013088	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
318586013089	Cu(I) binding site [ion binding]; other site
318586013090	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
318586013091	Protein of unknown function (DUF461); Region: DUF461; pfam04314
318586013092	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586013093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013094	dimer interface [polypeptide binding]; other site
318586013095	conserved gate region; other site
318586013096	putative PBP binding loops; other site
318586013097	ABC-ATPase subunit interface; other site
318586013098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013099	ABC-ATPase subunit interface; other site
318586013100	putative PBP binding loops; other site
318586013101	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586013102	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586013103	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586013104	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
318586013105	Walker A/P-loop; other site
318586013106	ATP binding site [chemical binding]; other site
318586013107	Q-loop/lid; other site
318586013108	ABC transporter signature motif; other site
318586013109	Walker B; other site
318586013110	D-loop; other site
318586013111	H-loop/switch region; other site
318586013112	TOBE domain; Region: TOBE_2; pfam08402
318586013113	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
318586013114	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
318586013115	[4Fe-4S] binding site [ion binding]; other site
318586013116	molybdopterin cofactor binding site; other site
318586013117	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
318586013118	molybdopterin cofactor binding site; other site
318586013119	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
318586013120	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
318586013121	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
318586013122	[2Fe-2S] cluster binding site [ion binding]; other site
318586013123	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
318586013124	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586013125	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
318586013126	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
318586013127	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
318586013128	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
318586013129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586013130	putative substrate translocation pore; other site
318586013131	NMT1-like family; Region: NMT1_2; pfam13379
318586013132	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
318586013133	NMT1-like family; Region: NMT1_2; pfam13379
318586013134	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
318586013135	ANTAR domain; Region: ANTAR; pfam03861
318586013136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
318586013137	MOSC domain; Region: MOSC; pfam03473
318586013138	3-alpha domain; Region: 3-alpha; pfam03475
318586013139	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
318586013140	pyridoxal binding site [chemical binding]; other site
318586013141	dimer interface [polypeptide binding]; other site
318586013142	ATP binding site [chemical binding]; other site
318586013143	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
318586013144	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
318586013145	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
318586013146	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
318586013147	RNA binding site [nucleotide binding]; other site
318586013148	Uncharacterized conserved protein [Function unknown]; Region: COG0062
318586013149	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
318586013150	putative ATP binding site [chemical binding]; other site
318586013151	putative substrate binding site [chemical binding]; other site
318586013152	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
318586013153	Nitrogen regulatory protein P-II; Region: P-II; smart00938
318586013154	glutamine synthetase; Provisional; Region: glnA; PRK09469
318586013155	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
318586013156	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
318586013157	adenylosuccinate lyase; Provisional; Region: PRK07492
318586013158	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
318586013159	tetramer interface [polypeptide binding]; other site
318586013160	active site
318586013161	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
318586013162	FliG C-terminal domain; Region: FliG_C; pfam01706
318586013163	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
318586013164	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
318586013165	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
318586013166	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
318586013167	active site
318586013168	substrate binding pocket [chemical binding]; other site
318586013169	dimer interface [polypeptide binding]; other site
318586013170	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586013171	active site
318586013172	replicative DNA helicase; Provisional; Region: PRK09165
318586013173	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
318586013174	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
318586013175	Walker A motif; other site
318586013176	ATP binding site [chemical binding]; other site
318586013177	Walker B motif; other site
318586013178	DNA binding loops [nucleotide binding]
318586013179	Protein of unknown function, DUF486; Region: DUF486; cl01236
318586013180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586013181	putative substrate translocation pore; other site
318586013182	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586013183	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586013184	non-specific DNA binding site [nucleotide binding]; other site
318586013185	salt bridge; other site
318586013186	sequence-specific DNA binding site [nucleotide binding]; other site
318586013187	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
318586013188	Domain of unknown function (DUF955); Region: DUF955; pfam06114
318586013189	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
318586013190	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
318586013191	Peptidase family M23; Region: Peptidase_M23; pfam01551
318586013192	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
318586013193	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
318586013194	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
318586013195	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
318586013196	active site
318586013197	(T/H)XGH motif; other site
318586013198	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
318586013199	FOG: CBS domain [General function prediction only]; Region: COG0517
318586013200	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586013201	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586013202	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
318586013203	dimerization interface [polypeptide binding]; other site
318586013204	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
318586013205	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
318586013206	tetrameric interface [polypeptide binding]; other site
318586013207	NAD binding site [chemical binding]; other site
318586013208	catalytic residues [active]
318586013209	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586013210	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586013211	active site
318586013212	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
318586013213	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586013214	substrate binding site [chemical binding]; other site
318586013215	oxyanion hole (OAH) forming residues; other site
318586013216	trimer interface [polypeptide binding]; other site
318586013217	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
318586013218	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
318586013219	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
318586013220	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
318586013221	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
318586013222	Walker A/P-loop; other site
318586013223	ATP binding site [chemical binding]; other site
318586013224	Q-loop/lid; other site
318586013225	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
318586013226	ABC transporter signature motif; other site
318586013227	Walker B; other site
318586013228	D-loop; other site
318586013229	H-loop/switch region; other site
318586013230	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
318586013231	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
318586013232	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
318586013233	cell division protein FtsZ; Validated; Region: PRK09330
318586013234	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
318586013235	nucleotide binding site [chemical binding]; other site
318586013236	SulA interaction site; other site
318586013237	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
318586013238	Cell division protein FtsA; Region: FtsA; smart00842
318586013239	Cell division protein FtsA; Region: FtsA; pfam14450
318586013240	Cell division protein FtsQ; Region: FtsQ; pfam03799
318586013241	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
318586013242	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
318586013243	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586013244	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
318586013245	FAD binding domain; Region: FAD_binding_4; pfam01565
318586013246	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
318586013247	Protein of unknown function (DUF2484); Region: DUF2484; pfam10658
318586013248	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
318586013249	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
318586013250	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
318586013251	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
318586013252	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
318586013253	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
318586013254	active site
318586013255	homodimer interface [polypeptide binding]; other site
318586013256	cell division protein FtsW; Region: ftsW; TIGR02614
318586013257	Predicted membrane protein [Function unknown]; Region: COG2259
318586013258	Homoserine O-succinyltransferase; Region: HTS; pfam04204
318586013259	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
318586013260	proposed active site lysine [active]
318586013261	conserved cys residue [active]
318586013262	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
318586013263	Repair protein; Region: Repair_PSII; pfam04536
318586013264	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586013265	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586013266	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
318586013267	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
318586013268	putative catalytic cysteine [active]
318586013269	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
318586013270	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
318586013271	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
318586013272	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
318586013273	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
318586013274	putative acyl-acceptor binding pocket; other site
318586013275	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
318586013276	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
318586013277	transmembrane helices; other site
318586013278	TrkA-C domain; Region: TrkA_C; pfam02080
318586013279	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
318586013280	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
318586013281	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
318586013282	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
318586013283	putative active site [active]
318586013284	metal binding site [ion binding]; metal-binding site
318586013285	homodimer binding site [polypeptide binding]; other site
318586013286	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
318586013287	ABC1 family; Region: ABC1; cl17513
318586013288	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
318586013289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586013290	S-adenosylmethionine binding site [chemical binding]; other site
318586013291	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
318586013292	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
318586013293	DNA binding site [nucleotide binding]
318586013294	catalytic residue [active]
318586013295	H2TH interface [polypeptide binding]; other site
318586013296	putative catalytic residues [active]
318586013297	turnover-facilitating residue; other site
318586013298	intercalation triad [nucleotide binding]; other site
318586013299	8OG recognition residue [nucleotide binding]; other site
318586013300	putative reading head residues; other site
318586013301	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
318586013302	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
318586013303	enoyl-CoA hydratase; Provisional; Region: PRK05862
318586013304	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586013305	substrate binding site [chemical binding]; other site
318586013306	oxyanion hole (OAH) forming residues; other site
318586013307	trimer interface [polypeptide binding]; other site
318586013308	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
318586013309	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
318586013310	dimer interface [polypeptide binding]; other site
318586013311	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586013312	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
318586013313	dimer interface [polypeptide binding]; other site
318586013314	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586013315	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586013316	MarR family; Region: MarR_2; pfam12802
318586013317	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586013318	dimerization interface [polypeptide binding]; other site
318586013319	putative DNA binding site [nucleotide binding]; other site
318586013320	putative Zn2+ binding site [ion binding]; other site
318586013321	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
318586013322	putative hydrophobic ligand binding site [chemical binding]; other site
318586013323	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
318586013324	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586013325	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586013326	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
318586013327	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
318586013328	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
318586013329	DNA binding residues [nucleotide binding]
318586013330	dimer interface [polypeptide binding]; other site
318586013331	putative metal binding site [ion binding]; other site
318586013332	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
318586013333	MarR family; Region: MarR_2; cl17246
318586013334	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
318586013335	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586013336	Coenzyme A binding pocket [chemical binding]; other site
318586013337	Methyltransferase domain; Region: Methyltransf_31; pfam13847
318586013338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586013339	S-adenosylmethionine binding site [chemical binding]; other site
318586013340	Transcriptional regulators [Transcription]; Region: MarR; COG1846
318586013341	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
318586013342	dimerization interface [polypeptide binding]; other site
318586013343	putative Zn2+ binding site [ion binding]; other site
318586013344	putative DNA binding site [nucleotide binding]; other site
318586013345	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
318586013346	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
318586013347	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586013348	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
318586013349	Na binding site [ion binding]; other site
318586013350	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
318586013351	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
318586013352	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
318586013353	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
318586013354	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
318586013355	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586013356	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586013357	DNA binding residues [nucleotide binding]
318586013358	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
318586013359	FecR protein; Region: FecR; pfam04773
318586013360	Secretin and TonB N terminus short domain; Region: STN; smart00965
318586013361	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
318586013362	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586013363	N-terminal plug; other site
318586013364	ligand-binding site [chemical binding]; other site
318586013365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586013366	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
318586013367	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586013368	Mitochondrial 28S ribosomal protein S32; Region: MRP-S32; pfam10210
318586013369	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
318586013370	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
318586013371	putative active site [active]
318586013372	putative NTP binding site [chemical binding]; other site
318586013373	putative nucleic acid binding site [nucleotide binding]; other site
318586013374	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
318586013375	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
318586013376	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
318586013377	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
318586013378	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
318586013379	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
318586013380	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
318586013381	putative active site [active]
318586013382	N-formylglutamate amidohydrolase; Region: FGase; cl01522
318586013383	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
318586013384	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
318586013385	DctM-like transporters; Region: DctM; pfam06808
318586013386	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586013387	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
318586013388	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
318586013389	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
318586013390	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586013391	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
318586013392	NAD(P) binding site [chemical binding]; other site
318586013393	catalytic residues [active]
318586013394	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
318586013395	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
318586013396	putative active site [active]
318586013397	metal binding site [ion binding]; metal-binding site
318586013398	acetyl-CoA synthetase; Provisional; Region: PRK00174
318586013399	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
318586013400	active site
318586013401	CoA binding site [chemical binding]; other site
318586013402	acyl-activating enzyme (AAE) consensus motif; other site
318586013403	AMP binding site [chemical binding]; other site
318586013404	acetate binding site [chemical binding]; other site
318586013405	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
318586013406	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
318586013407	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
318586013408	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
318586013409	Na binding site [ion binding]; other site
318586013410	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
318586013411	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
318586013412	ligand binding site [chemical binding]; other site
318586013413	flexible hinge region; other site
318586013414	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
318586013415	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
318586013416	metal binding triad; other site
318586013417	Response regulator receiver domain; Region: Response_reg; pfam00072
318586013418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586013419	active site
318586013420	phosphorylation site [posttranslational modification]
318586013421	intermolecular recognition site; other site
318586013422	dimerization interface [polypeptide binding]; other site
318586013423	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
318586013424	active site
318586013425	catalytic site [active]
318586013426	substrate binding site [chemical binding]; other site
318586013427	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
318586013428	active site
318586013429	catalytic triad [active]
318586013430	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
318586013431	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586013432	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586013433	DNA binding residues [nucleotide binding]
318586013434	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
318586013435	glycerate kinase; Region: TIGR00045
318586013436	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
318586013437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586013438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586013439	LysR substrate binding domain; Region: LysR_substrate; pfam03466
318586013440	dimerization interface [polypeptide binding]; other site
318586013441	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
318586013442	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586013443	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586013444	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
318586013445	EamA-like transporter family; Region: EamA; pfam00892
318586013446	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
318586013447	EamA-like transporter family; Region: EamA; pfam00892
318586013448	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
318586013449	Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434
318586013450	substrate binding site [chemical binding]; other site
318586013451	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
318586013452	substrate binding site [chemical binding]; other site
318586013453	ligand binding site [chemical binding]; other site
318586013454	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
318586013455	NADH(P)-binding; Region: NAD_binding_10; pfam13460
318586013456	NAD binding site [chemical binding]; other site
318586013457	substrate binding site [chemical binding]; other site
318586013458	putative active site [active]
318586013459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586013460	putative substrate translocation pore; other site
318586013461	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586013462	ParB-like nuclease domain; Region: ParBc; cl02129
318586013463	EamA-like transporter family; Region: EamA; pfam00892
318586013464	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586013465	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586013466	active site
318586013467	catalytic tetrad [active]
318586013468	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586013469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586013470	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
318586013471	putative effector binding pocket; other site
318586013472	putative dimerization interface [polypeptide binding]; other site
318586013473	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
318586013474	short chain dehydrogenase; Provisional; Region: PRK06523
318586013475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586013476	NAD(P) binding site [chemical binding]; other site
318586013477	active site
318586013478	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
318586013479	Predicted transcriptional regulators [Transcription]; Region: COG1733
318586013480	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
318586013481	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
318586013482	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
318586013483	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586013484	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586013485	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586013486	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586013487	dimerization interface [polypeptide binding]; other site
318586013488	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
318586013489	putative hydrophobic ligand binding site [chemical binding]; other site
318586013490	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
318586013491	short chain dehydrogenase; Provisional; Region: PRK07478
318586013492	classical (c) SDRs; Region: SDR_c; cd05233
318586013493	NAD(P) binding site [chemical binding]; other site
318586013494	active site
318586013495	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
318586013496	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
318586013497	ring oligomerisation interface [polypeptide binding]; other site
318586013498	ATP/Mg binding site [chemical binding]; other site
318586013499	stacking interactions; other site
318586013500	hinge regions; other site
318586013501	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
318586013502	oligomerisation interface [polypeptide binding]; other site
318586013503	mobile loop; other site
318586013504	roof hairpin; other site
318586013505	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
318586013506	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
318586013507	acyl-CoA synthetase; Validated; Region: PRK08162
318586013508	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
318586013509	acyl-activating enzyme (AAE) consensus motif; other site
318586013510	putative active site [active]
318586013511	AMP binding site [chemical binding]; other site
318586013512	putative CoA binding site [chemical binding]; other site
318586013513	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
318586013514	active site
318586013515	catalytic residue [active]
318586013516	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
318586013517	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
318586013518	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
318586013519	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
318586013520	molybdopterin cofactor binding site [chemical binding]; other site
318586013521	substrate binding site [chemical binding]; other site
318586013522	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
318586013523	molybdopterin cofactor binding site; other site
318586013524	hypothetical protein; Validated; Region: PRK07586
318586013525	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586013526	PYR/PP interface [polypeptide binding]; other site
318586013527	dimer interface [polypeptide binding]; other site
318586013528	TPP binding site [chemical binding]; other site
318586013529	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
318586013530	TPP-binding site [chemical binding]; other site
318586013531	dimer interface [polypeptide binding]; other site
318586013532	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
318586013533	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
318586013534	nucleotide binding site [chemical binding]; other site
318586013535	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
318586013536	intersubunit interface [polypeptide binding]; other site
318586013537	active site
318586013538	Zn2+ binding site [ion binding]; other site
318586013539	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
318586013540	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
318586013541	putative ligand binding site [chemical binding]; other site
318586013542	putative NAD binding site [chemical binding]; other site
318586013543	catalytic site [active]
318586013544	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586013545	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586013546	Coenzyme A transferase; Region: CoA_trans; smart00882
318586013547	Coenzyme A transferase; Region: CoA_trans; smart00882
318586013548	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586013549	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
318586013550	Walker A/P-loop; other site
318586013551	ATP binding site [chemical binding]; other site
318586013552	Q-loop/lid; other site
318586013553	ABC transporter signature motif; other site
318586013554	Walker B; other site
318586013555	D-loop; other site
318586013556	H-loop/switch region; other site
318586013557	TOBE domain; Region: TOBE_2; pfam08402
318586013558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013559	dimer interface [polypeptide binding]; other site
318586013560	conserved gate region; other site
318586013561	ABC-ATPase subunit interface; other site
318586013562	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586013563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013564	dimer interface [polypeptide binding]; other site
318586013565	conserved gate region; other site
318586013566	putative PBP binding loops; other site
318586013567	ABC-ATPase subunit interface; other site
318586013568	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586013569	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586013570	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586013571	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586013572	putative DNA binding site [nucleotide binding]; other site
318586013573	putative Zn2+ binding site [ion binding]; other site
318586013574	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586013575	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586013576	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
318586013577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
318586013578	FeS/SAM binding site; other site
318586013579	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
318586013580	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
318586013581	Fe-S cluster binding site [ion binding]; other site
318586013582	active site
318586013583	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
318586013584	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
318586013585	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
318586013586	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
318586013587	putative active site [active]
318586013588	putative active site [active]
318586013589	catalytic site [active]
318586013590	catalytic site [active]
318586013591	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
318586013592	putative active site [active]
318586013593	catalytic site [active]
318586013594	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586013595	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
318586013596	hydroperoxidase II; Provisional; Region: katE; PRK11249
318586013597	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
318586013598	heme binding pocket [chemical binding]; other site
318586013599	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
318586013600	domain interactions; other site
318586013601	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
318586013602	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586013603	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586013604	Predicted esterase [General function prediction only]; Region: COG0400
318586013605	dihydropyrimidinase; Provisional; Region: PRK13404
318586013606	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
318586013607	tetramer interface [polypeptide binding]; other site
318586013608	active site
318586013609	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586013610	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586013611	DNA-binding site [nucleotide binding]; DNA binding site
318586013612	FCD domain; Region: FCD; pfam07729
318586013613	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
318586013614	Winged helix-turn helix; Region: HTH_29; pfam13551
318586013615	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586013616	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
318586013617	DctM-like transporters; Region: DctM; pfam06808
318586013618	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586013619	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
318586013620	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586013621	active site
318586013622	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586013623	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586013624	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586013625	dimerization interface [polypeptide binding]; other site
318586013626	putative DNA binding site [nucleotide binding]; other site
318586013627	putative Zn2+ binding site [ion binding]; other site
318586013628	AsnC family; Region: AsnC_trans_reg; pfam01037
318586013629	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
318586013630	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
318586013631	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
318586013632	NAD binding site [chemical binding]; other site
318586013633	Phe binding site; other site
318586013634	Uncharacterized conserved protein [Function unknown]; Region: COG1284
318586013635	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
318586013636	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586013637	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586013638	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586013639	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
318586013640	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
318586013641	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
318586013642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586013643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586013644	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586013645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586013646	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
318586013647	Beta-lactamase; Region: Beta-lactamase; pfam00144
318586013648	Uncharacterized conserved protein [Function unknown]; Region: COG5476
318586013649	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
318586013650	MlrC C-terminus; Region: MlrC_C; pfam07171
318586013651	multifunctional aminopeptidase A; Provisional; Region: PRK00913
318586013652	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
318586013653	interface (dimer of trimers) [polypeptide binding]; other site
318586013654	Substrate-binding/catalytic site; other site
318586013655	Zn-binding sites [ion binding]; other site
318586013656	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
318586013657	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
318586013658	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
318586013659	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
318586013660	ornithine cyclodeaminase; Validated; Region: PRK07589
318586013661	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
318586013662	phenol 2-monooxygenase; Provisional; Region: PRK08294
318586013663	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
318586013664	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
318586013665	putative DNA binding site [nucleotide binding]; other site
318586013666	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586013667	putative Zn2+ binding site [ion binding]; other site
318586013668	AsnC family; Region: AsnC_trans_reg; pfam01037
318586013669	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586013670	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586013671	Putative cyclase; Region: Cyclase; pfam04199
318586013672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586013673	putative substrate translocation pore; other site
318586013674	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
318586013675	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
318586013676	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586013677	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586013678	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586013679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013680	dimer interface [polypeptide binding]; other site
318586013681	conserved gate region; other site
318586013682	putative PBP binding loops; other site
318586013683	ABC-ATPase subunit interface; other site
318586013684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013685	dimer interface [polypeptide binding]; other site
318586013686	conserved gate region; other site
318586013687	putative PBP binding loops; other site
318586013688	ABC-ATPase subunit interface; other site
318586013689	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586013690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586013691	Walker A/P-loop; other site
318586013692	ATP binding site [chemical binding]; other site
318586013693	Q-loop/lid; other site
318586013694	ABC transporter signature motif; other site
318586013695	Walker B; other site
318586013696	D-loop; other site
318586013697	H-loop/switch region; other site
318586013698	TOBE domain; Region: TOBE_2; pfam08402
318586013699	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
318586013700	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
318586013701	active site
318586013702	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
318586013703	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
318586013704	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
318586013705	putative active site [active]
318586013706	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
318586013707	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
318586013708	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586013709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586013710	dimer interface [polypeptide binding]; other site
318586013711	phosphorylation site [posttranslational modification]
318586013712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586013713	ATP binding site [chemical binding]; other site
318586013714	Mg2+ binding site [ion binding]; other site
318586013715	G-X-G motif; other site
318586013716	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586013717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586013718	active site
318586013719	phosphorylation site [posttranslational modification]
318586013720	intermolecular recognition site; other site
318586013721	dimerization interface [polypeptide binding]; other site
318586013722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586013723	ATP binding site [chemical binding]; other site
318586013724	Walker A motif; other site
318586013725	Walker B motif; other site
318586013726	arginine finger; other site
318586013727	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
318586013728	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586013729	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586013730	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586013731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013732	dimer interface [polypeptide binding]; other site
318586013733	conserved gate region; other site
318586013734	putative PBP binding loops; other site
318586013735	ABC-ATPase subunit interface; other site
318586013736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013737	dimer interface [polypeptide binding]; other site
318586013738	conserved gate region; other site
318586013739	putative PBP binding loops; other site
318586013740	ABC-ATPase subunit interface; other site
318586013741	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586013742	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586013743	Walker A/P-loop; other site
318586013744	ATP binding site [chemical binding]; other site
318586013745	Q-loop/lid; other site
318586013746	ABC transporter signature motif; other site
318586013747	Walker B; other site
318586013748	D-loop; other site
318586013749	H-loop/switch region; other site
318586013750	TOBE domain; Region: TOBE_2; pfam08402
318586013751	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
318586013752	catalytic core [active]
318586013753	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
318586013754	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
318586013755	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
318586013756	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
318586013757	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
318586013758	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
318586013759	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
318586013760	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
318586013761	shikimate binding site; other site
318586013762	NAD(P) binding site [chemical binding]; other site
318586013763	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
318586013764	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
318586013765	dimer interface [polypeptide binding]; other site
318586013766	NADP binding site [chemical binding]; other site
318586013767	catalytic residues [active]
318586013768	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
318586013769	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
318586013770	inhibitor site; inhibition site
318586013771	active site
318586013772	dimer interface [polypeptide binding]; other site
318586013773	catalytic residue [active]
318586013774	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586013775	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586013776	substrate binding pocket [chemical binding]; other site
318586013777	membrane-bound complex binding site; other site
318586013778	hinge residues; other site
318586013779	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586013780	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586013781	Walker A/P-loop; other site
318586013782	ATP binding site [chemical binding]; other site
318586013783	Q-loop/lid; other site
318586013784	ABC transporter signature motif; other site
318586013785	Walker B; other site
318586013786	D-loop; other site
318586013787	H-loop/switch region; other site
318586013788	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586013789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013790	dimer interface [polypeptide binding]; other site
318586013791	conserved gate region; other site
318586013792	putative PBP binding loops; other site
318586013793	ABC-ATPase subunit interface; other site
318586013794	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586013795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013796	dimer interface [polypeptide binding]; other site
318586013797	conserved gate region; other site
318586013798	putative PBP binding loops; other site
318586013799	ABC-ATPase subunit interface; other site
318586013800	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
318586013801	galactarate dehydratase; Region: galactar-dH20; TIGR03248
318586013802	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
318586013803	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586013804	DNA-binding site [nucleotide binding]; DNA binding site
318586013805	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586013806	FCD domain; Region: FCD; pfam07729
318586013807	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
318586013808	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
318586013809	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
318586013810	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
318586013811	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795
318586013812	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
318586013813	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
318586013814	active site
318586013815	substrate binding site [chemical binding]; other site
318586013816	FMN binding site [chemical binding]; other site
318586013817	putative catalytic residues [active]
318586013818	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
318586013819	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
318586013820	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
318586013821	riboflavin synthase subunit beta; Provisional; Region: PRK12419
318586013822	active site
318586013823	homopentamer interface [polypeptide binding]; other site
318586013824	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
318586013825	putative active site [active]
318586013826	putative catalytic site [active]
318586013827	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586013828	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586013829	PAS fold; Region: PAS; pfam00989
318586013830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
318586013831	putative active site [active]
318586013832	heme pocket [chemical binding]; other site
318586013833	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586013834	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586013835	DNA binding residues [nucleotide binding]
318586013836	dimerization interface [polypeptide binding]; other site
318586013837	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
318586013838	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
318586013839	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586013840	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586013841	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
318586013842	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586013843	Walker A/P-loop; other site
318586013844	ATP binding site [chemical binding]; other site
318586013845	Q-loop/lid; other site
318586013846	ABC transporter signature motif; other site
318586013847	Walker B; other site
318586013848	D-loop; other site
318586013849	H-loop/switch region; other site
318586013850	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
318586013851	Walker A/P-loop; other site
318586013852	ATP binding site [chemical binding]; other site
318586013853	Q-loop/lid; other site
318586013854	ABC transporter signature motif; other site
318586013855	Walker B; other site
318586013856	D-loop; other site
318586013857	H-loop/switch region; other site
318586013858	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
318586013859	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
318586013860	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
318586013861	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
318586013862	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
318586013863	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
318586013864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
318586013865	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
318586013866	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
318586013867	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
318586013868	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
318586013869	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
318586013870	Protein export membrane protein; Region: SecD_SecF; cl14618
318586013871	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586013872	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586013873	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
318586013874	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
318586013875	Cytochrome C' Region: Cytochrom_C_2; pfam01322
318586013876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586013877	dimerization interface [polypeptide binding]; other site
318586013878	putative DNA binding site [nucleotide binding]; other site
318586013879	putative Zn2+ binding site [ion binding]; other site
318586013880	Putative phosphatase (DUF442); Region: DUF442; cl17385
318586013881	Predicted transporter component [General function prediction only]; Region: COG2391
318586013882	Sulphur transport; Region: Sulf_transp; pfam04143
318586013883	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
318586013884	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
318586013885	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
318586013886	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
318586013887	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
318586013888	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
318586013889	dimer interface [polypeptide binding]; other site
318586013890	active site
318586013891	metal binding site [ion binding]; metal-binding site
318586013892	glutathione binding site [chemical binding]; other site
318586013893	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
318586013894	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
318586013895	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
318586013896	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
318586013897	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
318586013898	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
318586013899	Switch I; other site
318586013900	Switch II; other site
318586013901	septum formation inhibitor; Reviewed; Region: minC; PRK05177
318586013902	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
318586013903	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
318586013904	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
318586013905	active site
318586013906	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586013907	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586013908	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586013909	DctM-like transporters; Region: DctM; pfam06808
318586013910	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586013911	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
318586013912	NapD protein; Region: NapD; pfam03927
318586013913	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
318586013914	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
318586013915	[4Fe-4S] binding site [ion binding]; other site
318586013916	molybdopterin cofactor binding site; other site
318586013917	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
318586013918	molybdopterin cofactor binding site; other site
318586013919	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
318586013920	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
318586013921	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
318586013922	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
318586013923	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
318586013924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
318586013925	S-adenosylmethionine binding site [chemical binding]; other site
318586013926	Mechanosensitive ion channel; Region: MS_channel; pfam00924
318586013927	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
318586013928	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
318586013929	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
318586013930	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586013931	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586013932	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586013933	dimerization interface [polypeptide binding]; other site
318586013934	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
318586013935	Methylamine utilisation protein MauE; Region: MauE; pfam07291
318586013936	methylamine dehydrogenase accessory protein MauD; Region: MauD; TIGR02661
318586013937	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
318586013938	methylamine dehydrogenase (amicyanin) light chain; Region: TTQ_MADH_Lt; TIGR02659
318586013939	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
318586013940	amicyanin; Region: amicyanin; TIGR02657
318586013941	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
318586013942	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
318586013943	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
318586013944	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
318586013945	4Fe-4S binding domain; Region: Fer4_5; pfam12801
318586013946	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
318586013947	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
318586013948	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
318586013949	PhnA protein; Region: PhnA; pfam03831
318586013950	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
318586013951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586013952	active site
318586013953	phosphorylation site [posttranslational modification]
318586013954	intermolecular recognition site; other site
318586013955	dimerization interface [polypeptide binding]; other site
318586013956	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
318586013957	DNA binding residues [nucleotide binding]
318586013958	dimerization interface [polypeptide binding]; other site
318586013959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586013960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586013961	dimer interface [polypeptide binding]; other site
318586013962	phosphorylation site [posttranslational modification]
318586013963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586013964	ATP binding site [chemical binding]; other site
318586013965	Mg2+ binding site [ion binding]; other site
318586013966	G-X-G motif; other site
318586013967	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
318586013968	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
318586013969	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
318586013970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013971	dimer interface [polypeptide binding]; other site
318586013972	conserved gate region; other site
318586013973	ABC-ATPase subunit interface; other site
318586013974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586013975	dimer interface [polypeptide binding]; other site
318586013976	conserved gate region; other site
318586013977	putative PBP binding loops; other site
318586013978	ABC-ATPase subunit interface; other site
318586013979	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
318586013980	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
318586013981	Walker A/P-loop; other site
318586013982	ATP binding site [chemical binding]; other site
318586013983	Q-loop/lid; other site
318586013984	ABC transporter signature motif; other site
318586013985	Walker B; other site
318586013986	D-loop; other site
318586013987	H-loop/switch region; other site
318586013988	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
318586013989	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
318586013990	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
318586013991	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
318586013992	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586013993	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586013994	dimerization interface [polypeptide binding]; other site
318586013995	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
318586013996	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586013997	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586013998	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586013999	NAD(P) binding site [chemical binding]; other site
318586014000	catalytic residues [active]
318586014001	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
318586014002	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
318586014003	inhibitor site; inhibition site
318586014004	active site
318586014005	dimer interface [polypeptide binding]; other site
318586014006	catalytic residue [active]
318586014007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
318586014008	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
318586014009	Putative glucoamylase; Region: Glycoamylase; pfam10091
318586014010	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
318586014011	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
318586014012	N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067
318586014013	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586014014	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586014015	putative DNA binding site [nucleotide binding]; other site
318586014016	putative Zn2+ binding site [ion binding]; other site
318586014017	AsnC family; Region: AsnC_trans_reg; pfam01037
318586014018	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
318586014019	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
318586014020	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
318586014021	tetramer interface [polypeptide binding]; other site
318586014022	TPP-binding site [chemical binding]; other site
318586014023	heterodimer interface [polypeptide binding]; other site
318586014024	phosphorylation loop region [posttranslational modification]
318586014025	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
318586014026	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
318586014027	alpha subunit interface [polypeptide binding]; other site
318586014028	TPP binding site [chemical binding]; other site
318586014029	heterodimer interface [polypeptide binding]; other site
318586014030	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586014031	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
318586014032	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586014033	E3 interaction surface; other site
318586014034	lipoyl attachment site [posttranslational modification]; other site
318586014035	e3 binding domain; Region: E3_binding; pfam02817
318586014036	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
318586014037	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
318586014038	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
318586014039	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
318586014040	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
318586014041	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
318586014042	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
318586014043	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
318586014044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586014045	active site
318586014046	phosphorylation site [posttranslational modification]
318586014047	intermolecular recognition site; other site
318586014048	dimerization interface [polypeptide binding]; other site
318586014049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586014050	Walker A motif; other site
318586014051	ATP binding site [chemical binding]; other site
318586014052	Walker B motif; other site
318586014053	arginine finger; other site
318586014054	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
318586014055	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
318586014056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586014057	dimer interface [polypeptide binding]; other site
318586014058	phosphorylation site [posttranslational modification]
318586014059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586014060	ATP binding site [chemical binding]; other site
318586014061	Mg2+ binding site [ion binding]; other site
318586014062	G-X-G motif; other site
318586014063	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
318586014064	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
318586014065	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586014066	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586014067	DNA binding site [nucleotide binding]
318586014068	domain linker motif; other site
318586014069	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
318586014070	dimerization interface [polypeptide binding]; other site
318586014071	ligand binding site [chemical binding]; other site
318586014072	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
318586014073	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
318586014074	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
318586014075	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
318586014076	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
318586014077	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
318586014078	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586014079	Walker A/P-loop; other site
318586014080	ATP binding site [chemical binding]; other site
318586014081	Q-loop/lid; other site
318586014082	ABC transporter signature motif; other site
318586014083	Walker B; other site
318586014084	D-loop; other site
318586014085	H-loop/switch region; other site
318586014086	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586014087	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586014088	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586014089	TM-ABC transporter signature motif; other site
318586014090	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
318586014091	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
318586014092	putative ligand binding site [chemical binding]; other site
318586014093	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
318586014094	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586014095	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
318586014096	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
318586014097	Uncharacterized conserved protein [Function unknown]; Region: COG2128
318586014098	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
318586014099	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586014100	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
318586014101	active site
318586014102	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
318586014103	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
318586014104	active site
318586014105	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
318586014106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586014107	Walker A/P-loop; other site
318586014108	ATP binding site [chemical binding]; other site
318586014109	Q-loop/lid; other site
318586014110	ABC transporter signature motif; other site
318586014111	Walker B; other site
318586014112	D-loop; other site
318586014113	H-loop/switch region; other site
318586014114	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
318586014115	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586014116	Walker A/P-loop; other site
318586014117	ATP binding site [chemical binding]; other site
318586014118	Q-loop/lid; other site
318586014119	ABC transporter signature motif; other site
318586014120	Walker B; other site
318586014121	D-loop; other site
318586014122	H-loop/switch region; other site
318586014123	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586014124	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
318586014125	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
318586014126	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
318586014127	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
318586014128	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586014129	DNA-binding site [nucleotide binding]; DNA binding site
318586014130	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
318586014131	UTRA domain; Region: UTRA; pfam07702
318586014132	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
318586014133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014134	dimer interface [polypeptide binding]; other site
318586014135	conserved gate region; other site
318586014136	ABC-ATPase subunit interface; other site
318586014137	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
318586014138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014139	dimer interface [polypeptide binding]; other site
318586014140	conserved gate region; other site
318586014141	putative PBP binding loops; other site
318586014142	ABC-ATPase subunit interface; other site
318586014143	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
318586014144	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
318586014145	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
318586014146	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
318586014147	Walker A/P-loop; other site
318586014148	ATP binding site [chemical binding]; other site
318586014149	Q-loop/lid; other site
318586014150	ABC transporter signature motif; other site
318586014151	Walker B; other site
318586014152	D-loop; other site
318586014153	H-loop/switch region; other site
318586014154	Predicted flavoprotein [General function prediction only]; Region: COG0431
318586014155	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586014156	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
318586014157	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
318586014158	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
318586014159	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586014160	substrate binding site [chemical binding]; other site
318586014161	oxyanion hole (OAH) forming residues; other site
318586014162	trimer interface [polypeptide binding]; other site
318586014163	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
318586014164	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586014165	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586014166	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586014167	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586014168	Walker A/P-loop; other site
318586014169	ATP binding site [chemical binding]; other site
318586014170	Q-loop/lid; other site
318586014171	ABC transporter signature motif; other site
318586014172	Walker B; other site
318586014173	D-loop; other site
318586014174	H-loop/switch region; other site
318586014175	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586014176	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586014177	Walker A/P-loop; other site
318586014178	ATP binding site [chemical binding]; other site
318586014179	Q-loop/lid; other site
318586014180	ABC transporter signature motif; other site
318586014181	Walker B; other site
318586014182	D-loop; other site
318586014183	H-loop/switch region; other site
318586014184	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586014185	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586014186	TM-ABC transporter signature motif; other site
318586014187	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586014188	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586014189	TM-ABC transporter signature motif; other site
318586014190	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
318586014191	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
318586014192	putative ligand binding site [chemical binding]; other site
318586014193	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
318586014194	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586014195	NAD(P) binding site [chemical binding]; other site
318586014196	catalytic residues [active]
318586014197	enoyl-CoA hydratase; Provisional; Region: PRK08140
318586014198	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586014199	substrate binding site [chemical binding]; other site
318586014200	oxyanion hole (OAH) forming residues; other site
318586014201	trimer interface [polypeptide binding]; other site
318586014202	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
318586014203	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
318586014204	CoenzymeA binding site [chemical binding]; other site
318586014205	subunit interaction site [polypeptide binding]; other site
318586014206	PHB binding site; other site
318586014207	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
318586014208	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
318586014209	active site
318586014210	AMP binding site [chemical binding]; other site
318586014211	homodimer interface [polypeptide binding]; other site
318586014212	acyl-activating enzyme (AAE) consensus motif; other site
318586014213	CoA binding site [chemical binding]; other site
318586014214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
318586014215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586014216	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
318586014217	active site
318586014218	NTP binding site [chemical binding]; other site
318586014219	metal binding triad [ion binding]; metal-binding site
318586014220	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
318586014221	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
318586014222	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
318586014223	substrate binding site [chemical binding]; other site
318586014224	dimer interface [polypeptide binding]; other site
318586014225	NADP binding site [chemical binding]; other site
318586014226	catalytic residues [active]
318586014227	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
318586014228	substrate binding site [chemical binding]; other site
318586014229	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
318586014230	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
318586014231	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
318586014232	FAD binding pocket [chemical binding]; other site
318586014233	FAD binding motif [chemical binding]; other site
318586014234	phosphate binding motif [ion binding]; other site
318586014235	beta-alpha-beta structure motif; other site
318586014236	NAD(p) ribose binding residues [chemical binding]; other site
318586014237	NAD binding pocket [chemical binding]; other site
318586014238	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
318586014239	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586014240	catalytic loop [active]
318586014241	iron binding site [ion binding]; other site
318586014242	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
318586014243	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
318586014244	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
318586014245	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
318586014246	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
318586014247	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
318586014248	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
318586014249	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586014250	dimer interface [polypeptide binding]; other site
318586014251	active site
318586014252	PaaX-like protein; Region: PaaX; pfam07848
318586014253	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
318586014254	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
318586014255	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
318586014256	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
318586014257	Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748
318586014258	active site
318586014259	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586014260	DctM-like transporters; Region: DctM; pfam06808
318586014261	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586014262	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586014263	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586014264	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586014265	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
318586014266	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
318586014267	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
318586014268	active site
318586014269	acyl-CoA synthetase; Validated; Region: PRK07470
318586014270	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586014271	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
318586014272	acyl-activating enzyme (AAE) consensus motif; other site
318586014273	acyl-activating enzyme (AAE) consensus motif; other site
318586014274	putative AMP binding site [chemical binding]; other site
318586014275	putative active site [active]
318586014276	putative CoA binding site [chemical binding]; other site
318586014277	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720
318586014278	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
318586014279	classical (c) SDRs; Region: SDR_c; cd05233
318586014280	NAD(P) binding site [chemical binding]; other site
318586014281	active site
318586014282	Predicted membrane protein [Function unknown]; Region: COG3174
318586014283	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
318586014284	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
318586014285	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
318586014286	active site
318586014287	substrate binding site [chemical binding]; other site
318586014288	metal binding site [ion binding]; metal-binding site
318586014289	FtsH Extracellular; Region: FtsH_ext; pfam06480
318586014290	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
318586014291	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586014292	Walker A motif; other site
318586014293	ATP binding site [chemical binding]; other site
318586014294	Walker B motif; other site
318586014295	arginine finger; other site
318586014296	Peptidase family M41; Region: Peptidase_M41; pfam01434
318586014297	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586014298	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586014299	N-terminal plug; other site
318586014300	ligand-binding site [chemical binding]; other site
318586014301	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
318586014302	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
318586014303	Walker A/P-loop; other site
318586014304	ATP binding site [chemical binding]; other site
318586014305	Q-loop/lid; other site
318586014306	ABC transporter signature motif; other site
318586014307	Walker B; other site
318586014308	D-loop; other site
318586014309	H-loop/switch region; other site
318586014310	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
318586014311	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
318586014312	putative ligand binding residues [chemical binding]; other site
318586014313	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
318586014314	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
318586014315	ABC-ATPase subunit  interface; other site
318586014316	dimer interface [polypeptide binding]; other site
318586014317	putative PBP binding regions; other site
318586014318	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
318586014319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586014320	DNA-binding site [nucleotide binding]; DNA binding site
318586014321	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
318586014322	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586014323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586014324	homodimer interface [polypeptide binding]; other site
318586014325	catalytic residue [active]
318586014326	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
318586014327	Helix-turn-helix domain; Region: HTH_18; pfam12833
318586014328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586014329	Major Facilitator Superfamily; Region: MFS_1; pfam07690
318586014330	putative substrate translocation pore; other site
318586014331	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
318586014332	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586014333	DNA-binding site [nucleotide binding]; DNA binding site
318586014334	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
318586014335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586014336	homodimer interface [polypeptide binding]; other site
318586014337	catalytic residue [active]
318586014338	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
318586014339	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
318586014340	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
318586014341	motif II; other site
318586014342	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
318586014343	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
318586014344	putative NAD(P) binding site [chemical binding]; other site
318586014345	catalytic Zn binding site [ion binding]; other site
318586014346	sorbitol dehydrogenase; Provisional; Region: PRK07067
318586014347	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586014348	NAD(P) binding site [chemical binding]; other site
318586014349	active site
318586014350	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
318586014351	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
318586014352	Walker A/P-loop; other site
318586014353	ATP binding site [chemical binding]; other site
318586014354	Q-loop/lid; other site
318586014355	ABC transporter signature motif; other site
318586014356	Walker B; other site
318586014357	D-loop; other site
318586014358	H-loop/switch region; other site
318586014359	TOBE domain; Region: TOBE_2; pfam08402
318586014360	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
318586014361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014362	dimer interface [polypeptide binding]; other site
318586014363	conserved gate region; other site
318586014364	putative PBP binding loops; other site
318586014365	ABC-ATPase subunit interface; other site
318586014366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014367	dimer interface [polypeptide binding]; other site
318586014368	conserved gate region; other site
318586014369	putative PBP binding loops; other site
318586014370	ABC-ATPase subunit interface; other site
318586014371	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
318586014372	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
318586014373	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586014374	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586014375	DNA binding site [nucleotide binding]
318586014376	domain linker motif; other site
318586014377	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
318586014378	dimerization interface [polypeptide binding]; other site
318586014379	ligand binding site [chemical binding]; other site
318586014380	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
318586014381	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586014382	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
318586014383	substrate binding site [chemical binding]; other site
318586014384	ATP binding site [chemical binding]; other site
318586014385	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586014386	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
318586014387	TM-ABC transporter signature motif; other site
318586014388	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
318586014389	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
318586014390	Walker A/P-loop; other site
318586014391	ATP binding site [chemical binding]; other site
318586014392	Q-loop/lid; other site
318586014393	ABC transporter signature motif; other site
318586014394	Walker B; other site
318586014395	D-loop; other site
318586014396	H-loop/switch region; other site
318586014397	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
318586014398	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322
318586014399	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
318586014400	putative ligand binding site [chemical binding]; other site
318586014401	Caspase domain; Region: Peptidase_C14; pfam00656
318586014402	substrate pocket [chemical binding]; other site
318586014403	active site
318586014404	dimer interface [polypeptide binding]; other site
318586014405	proteolytic cleavage site; other site
318586014406	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
318586014407	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
318586014408	substrate binding site [chemical binding]; other site
318586014409	Protein of unknown function (DUF521); Region: DUF521; pfam04412
318586014410	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
318586014411	substrate binding site [chemical binding]; other site
318586014412	ligand binding site [chemical binding]; other site
318586014413	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
318586014414	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586014415	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
318586014416	DctM-like transporters; Region: DctM; pfam06808
318586014417	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586014418	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586014419	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
318586014420	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
318586014421	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
318586014422	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586014423	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586014424	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586014425	Walker A/P-loop; other site
318586014426	ATP binding site [chemical binding]; other site
318586014427	Q-loop/lid; other site
318586014428	ABC transporter signature motif; other site
318586014429	Walker B; other site
318586014430	D-loop; other site
318586014431	H-loop/switch region; other site
318586014432	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586014433	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586014434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014435	dimer interface [polypeptide binding]; other site
318586014436	conserved gate region; other site
318586014437	putative PBP binding loops; other site
318586014438	ABC-ATPase subunit interface; other site
318586014439	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586014440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014441	dimer interface [polypeptide binding]; other site
318586014442	conserved gate region; other site
318586014443	putative PBP binding loops; other site
318586014444	ABC-ATPase subunit interface; other site
318586014445	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586014446	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586014447	substrate binding pocket [chemical binding]; other site
318586014448	membrane-bound complex binding site; other site
318586014449	hinge residues; other site
318586014450	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
318586014451	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
318586014452	dimer interface [polypeptide binding]; other site
318586014453	NADP binding site [chemical binding]; other site
318586014454	catalytic residues [active]
318586014455	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
318586014456	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
318586014457	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
318586014458	inhibitor site; inhibition site
318586014459	active site
318586014460	dimer interface [polypeptide binding]; other site
318586014461	catalytic residue [active]
318586014462	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586014463	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586014464	DNA-binding site [nucleotide binding]; DNA binding site
318586014465	FCD domain; Region: FCD; pfam07729
318586014466	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
318586014467	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
318586014468	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586014469	non-specific DNA binding site [nucleotide binding]; other site
318586014470	salt bridge; other site
318586014471	sequence-specific DNA binding site [nucleotide binding]; other site
318586014472	Cupin domain; Region: Cupin_2; pfam07883
318586014473	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
318586014474	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
318586014475	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
318586014476	FAD binding domain; Region: FAD_binding_4; pfam01565
318586014477	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586014478	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586014479	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586014480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586014481	Walker A/P-loop; other site
318586014482	ATP binding site [chemical binding]; other site
318586014483	Q-loop/lid; other site
318586014484	ABC transporter signature motif; other site
318586014485	Walker B; other site
318586014486	D-loop; other site
318586014487	H-loop/switch region; other site
318586014488	TOBE domain; Region: TOBE_2; pfam08402
318586014489	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586014490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014491	dimer interface [polypeptide binding]; other site
318586014492	conserved gate region; other site
318586014493	putative PBP binding loops; other site
318586014494	ABC-ATPase subunit interface; other site
318586014495	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586014496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014497	dimer interface [polypeptide binding]; other site
318586014498	conserved gate region; other site
318586014499	putative PBP binding loops; other site
318586014500	ABC-ATPase subunit interface; other site
318586014501	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
318586014502	Class I aldolases; Region: Aldolase_Class_I; cl17187
318586014503	catalytic residue [active]
318586014504	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
318586014505	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586014506	phosphate binding site [ion binding]; other site
318586014507	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
318586014508	active site
318586014509	catalytic residues [active]
318586014510	metal binding site [ion binding]; metal-binding site
318586014511	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
318586014512	CoA-transferase family III; Region: CoA_transf_3; pfam02515
318586014513	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586014514	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586014515	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586014516	dimerization interface [polypeptide binding]; other site
318586014517	NMT1/THI5 like; Region: NMT1; pfam09084
318586014518	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586014519	substrate binding pocket [chemical binding]; other site
318586014520	membrane-bound complex binding site; other site
318586014521	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586014522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014523	dimer interface [polypeptide binding]; other site
318586014524	conserved gate region; other site
318586014525	putative PBP binding loops; other site
318586014526	ABC-ATPase subunit interface; other site
318586014527	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586014528	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
318586014529	Walker A/P-loop; other site
318586014530	ATP binding site [chemical binding]; other site
318586014531	Q-loop/lid; other site
318586014532	ABC transporter signature motif; other site
318586014533	Walker B; other site
318586014534	D-loop; other site
318586014535	H-loop/switch region; other site
318586014536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014537	dimer interface [polypeptide binding]; other site
318586014538	conserved gate region; other site
318586014539	ABC-ATPase subunit interface; other site
318586014540	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
318586014541	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
318586014542	Walker A/P-loop; other site
318586014543	ATP binding site [chemical binding]; other site
318586014544	Q-loop/lid; other site
318586014545	ABC transporter signature motif; other site
318586014546	Walker B; other site
318586014547	D-loop; other site
318586014548	H-loop/switch region; other site
318586014549	FOG: CBS domain [General function prediction only]; Region: COG0517
318586014550	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
318586014551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014552	dimer interface [polypeptide binding]; other site
318586014553	conserved gate region; other site
318586014554	putative PBP binding loops; other site
318586014555	ABC-ATPase subunit interface; other site
318586014556	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
318586014557	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
318586014558	Predicted amidohydrolase [General function prediction only]; Region: COG0388
318586014559	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
318586014560	putative active site [active]
318586014561	catalytic triad [active]
318586014562	putative dimer interface [polypeptide binding]; other site
318586014563	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586014564	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
318586014565	active site
318586014566	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
318586014567	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586014568	acyl-activating enzyme (AAE) consensus motif; other site
318586014569	AMP binding site [chemical binding]; other site
318586014570	active site
318586014571	CoA binding site [chemical binding]; other site
318586014572	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
318586014573	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586014574	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
318586014575	conserved cys residue [active]
318586014576	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586014577	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586014578	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586014579	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
318586014580	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
318586014581	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
318586014582	FAD binding pocket [chemical binding]; other site
318586014583	FAD binding motif [chemical binding]; other site
318586014584	phosphate binding motif [ion binding]; other site
318586014585	beta-alpha-beta structure motif; other site
318586014586	NAD binding pocket [chemical binding]; other site
318586014587	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
318586014588	catalytic loop [active]
318586014589	iron binding site [ion binding]; other site
318586014590	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
318586014591	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
318586014592	[2Fe-2S] cluster binding site [ion binding]; other site
318586014593	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
318586014594	putative alpha subunit interface [polypeptide binding]; other site
318586014595	putative active site [active]
318586014596	putative substrate binding site [chemical binding]; other site
318586014597	Fe binding site [ion binding]; other site
318586014598	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
318586014599	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
318586014600	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
318586014601	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
318586014602	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
318586014603	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586014604	Walker A/P-loop; other site
318586014605	ATP binding site [chemical binding]; other site
318586014606	Q-loop/lid; other site
318586014607	ABC transporter signature motif; other site
318586014608	Walker B; other site
318586014609	D-loop; other site
318586014610	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586014611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014612	dimer interface [polypeptide binding]; other site
318586014613	conserved gate region; other site
318586014614	putative PBP binding loops; other site
318586014615	ABC-ATPase subunit interface; other site
318586014616	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
318586014617	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
318586014618	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
318586014619	putative active site [active]
318586014620	putative substrate binding site [chemical binding]; other site
318586014621	putative cosubstrate binding site; other site
318586014622	catalytic site [active]
318586014623	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
318586014624	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
318586014625	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
318586014626	homodimer interface [polypeptide binding]; other site
318586014627	NADP binding site [chemical binding]; other site
318586014628	substrate binding site [chemical binding]; other site
318586014629	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
318586014630	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
318586014631	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
318586014632	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
318586014633	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
318586014634	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
318586014635	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586014636	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586014637	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
318586014638	conserved cys residue [active]
318586014639	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
318586014640	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586014641	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586014642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014643	dimer interface [polypeptide binding]; other site
318586014644	conserved gate region; other site
318586014645	putative PBP binding loops; other site
318586014646	ABC-ATPase subunit interface; other site
318586014647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014648	dimer interface [polypeptide binding]; other site
318586014649	conserved gate region; other site
318586014650	putative PBP binding loops; other site
318586014651	ABC-ATPase subunit interface; other site
318586014652	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586014653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586014654	Walker A/P-loop; other site
318586014655	ATP binding site [chemical binding]; other site
318586014656	Q-loop/lid; other site
318586014657	ABC transporter signature motif; other site
318586014658	Walker B; other site
318586014659	D-loop; other site
318586014660	H-loop/switch region; other site
318586014661	TOBE domain; Region: TOBE_2; pfam08402
318586014662	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
318586014663	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
318586014664	active site
318586014665	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
318586014666	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
318586014667	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
318586014668	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586014669	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586014670	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
318586014671	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
318586014672	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
318586014673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
318586014674	non-specific DNA binding site [nucleotide binding]; other site
318586014675	salt bridge; other site
318586014676	sequence-specific DNA binding site [nucleotide binding]; other site
318586014677	Cupin domain; Region: Cupin_2; pfam07883
318586014678	Transposase, Mutator family; Region: Transposase_mut; pfam00872
318586014679	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
318586014680	active site
318586014681	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
318586014682	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586014683	ATP-grasp domain; Region: ATP-grasp_4; cl17255
318586014684	Transcriptional regulator [Transcription]; Region: IclR; COG1414
318586014685	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
318586014686	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586014687	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586014688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014689	dimer interface [polypeptide binding]; other site
318586014690	conserved gate region; other site
318586014691	putative PBP binding loops; other site
318586014692	ABC-ATPase subunit interface; other site
318586014693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014694	dimer interface [polypeptide binding]; other site
318586014695	conserved gate region; other site
318586014696	putative PBP binding loops; other site
318586014697	ABC-ATPase subunit interface; other site
318586014698	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586014699	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586014700	Walker A/P-loop; other site
318586014701	ATP binding site [chemical binding]; other site
318586014702	Q-loop/lid; other site
318586014703	ABC transporter signature motif; other site
318586014704	Walker B; other site
318586014705	D-loop; other site
318586014706	H-loop/switch region; other site
318586014707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586014708	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586014709	substrate binding pocket [chemical binding]; other site
318586014710	membrane-bound complex binding site; other site
318586014711	hinge residues; other site
318586014712	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
318586014713	galactarate dehydratase; Region: galactar-dH20; TIGR03248
318586014714	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
318586014715	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
318586014716	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
318586014717	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
318586014718	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
318586014719	active site
318586014720	intersubunit interface [polypeptide binding]; other site
318586014721	catalytic residue [active]
318586014722	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
318586014723	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
318586014724	putative NAD(P) binding site [chemical binding]; other site
318586014725	catalytic Zn binding site [ion binding]; other site
318586014726	structural Zn binding site [ion binding]; other site
318586014727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586014728	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586014729	NAD(P) binding site [chemical binding]; other site
318586014730	active site
318586014731	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
318586014732	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
318586014733	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
318586014734	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
318586014735	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586014736	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586014737	hypothetical protein; Provisional; Region: PRK07475
318586014738	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
318586014739	Flavoprotein; Region: Flavoprotein; pfam02441
318586014740	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
318586014741	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
318586014742	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586014743	DNA-binding site [nucleotide binding]; DNA binding site
318586014744	UTRA domain; Region: UTRA; pfam07702
318586014745	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
318586014746	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
318586014747	NAD(P) binding site [chemical binding]; other site
318586014748	catalytic residues [active]
318586014749	thiamine pyrophosphate protein; Validated; Region: PRK08199
318586014750	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
318586014751	PYR/PP interface [polypeptide binding]; other site
318586014752	dimer interface [polypeptide binding]; other site
318586014753	TPP binding site [chemical binding]; other site
318586014754	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
318586014755	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
318586014756	TPP-binding site [chemical binding]; other site
318586014757	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
318586014758	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
318586014759	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586014760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586014761	Walker A/P-loop; other site
318586014762	ATP binding site [chemical binding]; other site
318586014763	Q-loop/lid; other site
318586014764	ABC transporter signature motif; other site
318586014765	Walker B; other site
318586014766	D-loop; other site
318586014767	H-loop/switch region; other site
318586014768	TOBE domain; Region: TOBE_2; pfam08402
318586014769	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
318586014770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014771	dimer interface [polypeptide binding]; other site
318586014772	conserved gate region; other site
318586014773	putative PBP binding loops; other site
318586014774	ABC-ATPase subunit interface; other site
318586014775	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586014776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014777	dimer interface [polypeptide binding]; other site
318586014778	conserved gate region; other site
318586014779	putative PBP binding loops; other site
318586014780	ABC-ATPase subunit interface; other site
318586014781	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
318586014782	Protein of unknown function DUF72; Region: DUF72; pfam01904
318586014783	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
318586014784	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
318586014785	putative active site [active]
318586014786	putative FMN binding site [chemical binding]; other site
318586014787	putative catalytic residue [active]
318586014788	putative substrate binding site [chemical binding]; other site
318586014789	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586014790	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
318586014791	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
318586014792	dimerization interface [polypeptide binding]; other site
318586014793	Putative ammonia monooxygenase; Region: AmoA; pfam05145
318586014794	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
318586014795	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
318586014796	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
318586014797	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
318586014798	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586014799	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
318586014800	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586014801	hydroxyglutarate oxidase; Provisional; Region: PRK11728
318586014802	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586014803	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586014804	putative DNA binding site [nucleotide binding]; other site
318586014805	putative Zn2+ binding site [ion binding]; other site
318586014806	AsnC family; Region: AsnC_trans_reg; pfam01037
318586014807	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586014808	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586014809	Walker A/P-loop; other site
318586014810	ATP binding site [chemical binding]; other site
318586014811	Q-loop/lid; other site
318586014812	ABC transporter signature motif; other site
318586014813	Walker B; other site
318586014814	D-loop; other site
318586014815	H-loop/switch region; other site
318586014816	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586014817	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586014818	Walker A/P-loop; other site
318586014819	ATP binding site [chemical binding]; other site
318586014820	Q-loop/lid; other site
318586014821	ABC transporter signature motif; other site
318586014822	Walker B; other site
318586014823	D-loop; other site
318586014824	H-loop/switch region; other site
318586014825	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586014826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014827	dimer interface [polypeptide binding]; other site
318586014828	conserved gate region; other site
318586014829	ABC-ATPase subunit interface; other site
318586014830	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586014831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014832	dimer interface [polypeptide binding]; other site
318586014833	conserved gate region; other site
318586014834	putative PBP binding loops; other site
318586014835	ABC-ATPase subunit interface; other site
318586014836	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586014837	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
318586014838	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
318586014839	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
318586014840	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
318586014841	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
318586014842	putative ligand binding site [chemical binding]; other site
318586014843	NAD binding site [chemical binding]; other site
318586014844	dimerization interface [polypeptide binding]; other site
318586014845	catalytic site [active]
318586014846	hypothetical protein; Provisional; Region: PRK05965
318586014847	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
318586014848	inhibitor-cofactor binding pocket; inhibition site
318586014849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586014850	catalytic residue [active]
318586014851	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
318586014852	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
318586014853	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
318586014854	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
318586014855	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
318586014856	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
318586014857	succinic semialdehyde dehydrogenase; Region: PLN02278
318586014858	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
318586014859	tetramerization interface [polypeptide binding]; other site
318586014860	NAD(P) binding site [chemical binding]; other site
318586014861	catalytic residues [active]
318586014862	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
318586014863	tartrate dehydrogenase; Region: TTC; TIGR02089
318586014864	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
318586014865	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
318586014866	NAD(P) binding site [chemical binding]; other site
318586014867	catalytic residues [active]
318586014868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586014869	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
318586014870	putative dimerization interface [polypeptide binding]; other site
318586014871	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
318586014872	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
318586014873	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
318586014874	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
318586014875	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
318586014876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
318586014877	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
318586014878	Coenzyme A binding pocket [chemical binding]; other site
318586014879	acetylornithine deacetylase; Provisional; Region: PRK07522
318586014880	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
318586014881	metal binding site [ion binding]; metal-binding site
318586014882	putative dimer interface [polypeptide binding]; other site
318586014883	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
318586014884	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
318586014885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
318586014886	Walker A motif; other site
318586014887	ATP binding site [chemical binding]; other site
318586014888	Walker B motif; other site
318586014889	arginine finger; other site
318586014890	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
318586014891	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
318586014892	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
318586014893	putative NAD(P) binding site [chemical binding]; other site
318586014894	catalytic Zn binding site [ion binding]; other site
318586014895	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
318586014896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586014897	acetoin reductases; Region: 23BDH; TIGR02415
318586014898	NAD(P) binding site [chemical binding]; other site
318586014899	active site
318586014900	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
318586014901	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
318586014902	E3 interaction surface; other site
318586014903	lipoyl attachment site [posttranslational modification]; other site
318586014904	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
318586014905	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
318586014906	nucleophilic elbow; other site
318586014907	catalytic triad; other site
318586014908	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
318586014909	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
318586014910	alpha subunit interface [polypeptide binding]; other site
318586014911	TPP binding site [chemical binding]; other site
318586014912	heterodimer interface [polypeptide binding]; other site
318586014913	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
318586014914	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
318586014915	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
318586014916	tetramer interface [polypeptide binding]; other site
318586014917	TPP-binding site [chemical binding]; other site
318586014918	heterodimer interface [polypeptide binding]; other site
318586014919	phosphorylation loop region [posttranslational modification]
318586014920	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
318586014921	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508
318586014922	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
318586014923	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
318586014924	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
318586014925	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
318586014926	Domain of unknown function DUF20; Region: UPF0118; pfam01594
318586014927	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
318586014928	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
318586014929	catalytic residues [active]
318586014930	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
318586014931	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
318586014932	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
318586014933	NADP binding site [chemical binding]; other site
318586014934	dimer interface [polypeptide binding]; other site
318586014935	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
318586014936	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586014937	substrate binding site [chemical binding]; other site
318586014938	oxyanion hole (OAH) forming residues; other site
318586014939	trimer interface [polypeptide binding]; other site
318586014940	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
318586014941	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586014942	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
318586014943	putative ligand binding site [chemical binding]; other site
318586014944	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586014945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586014946	DNA-binding site [nucleotide binding]; DNA binding site
318586014947	FCD domain; Region: FCD; pfam07729
318586014948	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
318586014949	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
318586014950	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
318586014951	CoA binding domain; Region: CoA_binding_2; pfam13380
318586014952	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
318586014953	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586014954	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586014955	Walker A/P-loop; other site
318586014956	ATP binding site [chemical binding]; other site
318586014957	Q-loop/lid; other site
318586014958	ABC transporter signature motif; other site
318586014959	Walker B; other site
318586014960	D-loop; other site
318586014961	H-loop/switch region; other site
318586014962	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586014963	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586014964	Walker A/P-loop; other site
318586014965	ATP binding site [chemical binding]; other site
318586014966	Q-loop/lid; other site
318586014967	ABC transporter signature motif; other site
318586014968	Walker B; other site
318586014969	D-loop; other site
318586014970	H-loop/switch region; other site
318586014971	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586014972	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
318586014973	TM-ABC transporter signature motif; other site
318586014974	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586014975	TM-ABC transporter signature motif; other site
318586014976	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
318586014977	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
318586014978	active site residue [active]
318586014979	Cupin domain; Region: Cupin_2; cl17218
318586014980	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586014981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586014982	Walker A/P-loop; other site
318586014983	ATP binding site [chemical binding]; other site
318586014984	Q-loop/lid; other site
318586014985	ABC transporter signature motif; other site
318586014986	Walker B; other site
318586014987	D-loop; other site
318586014988	H-loop/switch region; other site
318586014989	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586014990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586014991	dimer interface [polypeptide binding]; other site
318586014992	conserved gate region; other site
318586014993	putative PBP binding loops; other site
318586014994	ABC-ATPase subunit interface; other site
318586014995	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
318586014996	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586014997	substrate binding pocket [chemical binding]; other site
318586014998	membrane-bound complex binding site; other site
318586014999	hinge residues; other site
318586015000	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
318586015001	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
318586015002	active site
318586015003	non-prolyl cis peptide bond; other site
318586015004	CopC domain; Region: CopC; pfam04234
318586015005	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
318586015006	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586015007	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
318586015008	Walker A/P-loop; other site
318586015009	ATP binding site [chemical binding]; other site
318586015010	Q-loop/lid; other site
318586015011	ABC transporter signature motif; other site
318586015012	Walker B; other site
318586015013	D-loop; other site
318586015014	H-loop/switch region; other site
318586015015	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586015016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015017	putative PBP binding loops; other site
318586015018	dimer interface [polypeptide binding]; other site
318586015019	ABC-ATPase subunit interface; other site
318586015020	NMT1/THI5 like; Region: NMT1; pfam09084
318586015021	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586015022	substrate binding pocket [chemical binding]; other site
318586015023	membrane-bound complex binding site; other site
318586015024	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
318586015025	active site
318586015026	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
318586015027	dimer interface [polypeptide binding]; other site
318586015028	non-prolyl cis peptide bond; other site
318586015029	insertion regions; other site
318586015030	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
318586015031	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
318586015032	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
318586015033	serine O-acetyltransferase; Region: cysE; TIGR01172
318586015034	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
318586015035	trimer interface [polypeptide binding]; other site
318586015036	active site
318586015037	substrate binding site [chemical binding]; other site
318586015038	CoA binding site [chemical binding]; other site
318586015039	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
318586015040	dimer interface [polypeptide binding]; other site
318586015041	FMN binding site [chemical binding]; other site
318586015042	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
318586015043	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
318586015044	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
318586015045	Bacterial transcriptional regulator; Region: IclR; pfam01614
318586015046	Coenzyme A transferase; Region: CoA_trans; cl17247
318586015047	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
318586015048	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
318586015049	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
318586015050	dimer interface [polypeptide binding]; other site
318586015051	active site
318586015052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
318586015053	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
318586015054	NAD(P) binding site [chemical binding]; other site
318586015055	active site
318586015056	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
318586015057	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
318586015058	active site
318586015059	nucleotide binding site [chemical binding]; other site
318586015060	HIGH motif; other site
318586015061	KMSKS motif; other site
318586015062	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
318586015063	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
318586015064	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
318586015065	putative ADP-binding pocket [chemical binding]; other site
318586015066	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586015067	LicD family; Region: LicD; pfam04991
318586015068	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
318586015069	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
318586015070	Walker A/P-loop; other site
318586015071	ATP binding site [chemical binding]; other site
318586015072	Q-loop/lid; other site
318586015073	ABC transporter signature motif; other site
318586015074	Walker B; other site
318586015075	D-loop; other site
318586015076	H-loop/switch region; other site
318586015077	Cobalt transport protein; Region: CbiQ; cl00463
318586015078	BioY family; Region: BioY; pfam02632
318586015079	Initiator Replication protein; Region: Rep_3; pfam01051
318586015080	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
318586015081	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
318586015082	P-loop; other site
318586015083	Magnesium ion binding site [ion binding]; other site
318586015084	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
318586015085	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
318586015086	ParB-like nuclease domain; Region: ParBc; pfam02195
318586015087	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
318586015088	Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177
318586015089	Walker A/P-loop; other site
318586015090	ATP binding site [chemical binding]; other site
318586015091	Q-loop/lid; other site
318586015092	ABC transporter signature motif; other site
318586015093	Walker B; other site
318586015094	D-loop; other site
318586015095	H-loop/switch region; other site
318586015096	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
318586015097	ABC-2 type transporter; Region: ABC2_membrane; cl17235
318586015098	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
318586015099	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
318586015100	putative ADP-binding pocket [chemical binding]; other site
318586015101	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
318586015102	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
318586015103	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
318586015104	UDP-galactopyranose mutase; Region: GLF; pfam03275
318586015105	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
318586015106	active site
318586015107	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
318586015108	catalytic tetrad [active]
318586015109	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
318586015110	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586015111	phosphate binding site [ion binding]; other site
318586015112	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
318586015113	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
318586015114	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
318586015115	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
318586015116	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
318586015117	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
318586015118	Walker A/P-loop; other site
318586015119	ATP binding site [chemical binding]; other site
318586015120	Q-loop/lid; other site
318586015121	ABC transporter signature motif; other site
318586015122	Walker B; other site
318586015123	D-loop; other site
318586015124	H-loop/switch region; other site
318586015125	TOBE domain; Region: TOBE_2; pfam08402
318586015126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015127	dimer interface [polypeptide binding]; other site
318586015128	conserved gate region; other site
318586015129	putative PBP binding loops; other site
318586015130	ABC-ATPase subunit interface; other site
318586015131	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
318586015132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015133	dimer interface [polypeptide binding]; other site
318586015134	conserved gate region; other site
318586015135	putative PBP binding loops; other site
318586015136	ABC-ATPase subunit interface; other site
318586015137	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
318586015138	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
318586015139	active site
318586015140	catalytic site [active]
318586015141	Zn binding site [ion binding]; other site
318586015142	tetramer interface [polypeptide binding]; other site
318586015143	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586015144	classical (c) SDRs; Region: SDR_c; cd05233
318586015145	NAD(P) binding site [chemical binding]; other site
318586015146	active site
318586015147	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586015148	classical (c) SDRs; Region: SDR_c; cd05233
318586015149	NAD(P) binding site [chemical binding]; other site
318586015150	active site
318586015151	putative amidase; Provisional; Region: PRK06169
318586015152	Amidase; Region: Amidase; pfam01425
318586015153	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
318586015154	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
318586015155	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
318586015156	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
318586015157	Walker A/P-loop; other site
318586015158	ATP binding site [chemical binding]; other site
318586015159	Q-loop/lid; other site
318586015160	ABC transporter signature motif; other site
318586015161	Walker B; other site
318586015162	D-loop; other site
318586015163	H-loop/switch region; other site
318586015164	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586015165	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
318586015166	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
318586015167	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
318586015168	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586015169	substrate binding site [chemical binding]; other site
318586015170	ATP binding site [chemical binding]; other site
318586015171	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
318586015172	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
318586015173	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
318586015174	mannonate dehydratase; Provisional; Region: PRK03906
318586015175	mannonate dehydratase; Region: uxuA; TIGR00695
318586015176	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
318586015177	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
318586015178	phosphate binding site [ion binding]; other site
318586015179	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
318586015180	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
318586015181	putative NAD(P) binding site [chemical binding]; other site
318586015182	catalytic Zn binding site [ion binding]; other site
318586015183	DctM-like transporters; Region: DctM; pfam06808
318586015184	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
318586015185	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
318586015186	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
318586015187	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
318586015188	Transcriptional regulators [Transcription]; Region: GntR; COG1802
318586015189	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
318586015190	DNA-binding site [nucleotide binding]; DNA binding site
318586015191	FCD domain; Region: FCD; pfam07729
318586015192	Transcriptional regulator [Transcription]; Region: LysR; COG0583
318586015193	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
318586015194	LysR substrate binding domain; Region: LysR_substrate; pfam03466
318586015195	dimerization interface [polypeptide binding]; other site
318586015196	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
318586015197	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
318586015198	homodimer interface [polypeptide binding]; other site
318586015199	substrate-cofactor binding pocket; other site
318586015200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
318586015201	catalytic residue [active]
318586015202	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
318586015203	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
318586015204	conserved cys residue [active]
318586015205	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
318586015206	Uncharacterized conserved protein [Function unknown]; Region: COG3246
318586015207	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
318586015208	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
318586015209	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
318586015210	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586015211	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586015212	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586015213	active site
318586015214	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
318586015215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015216	dimer interface [polypeptide binding]; other site
318586015217	conserved gate region; other site
318586015218	ABC-ATPase subunit interface; other site
318586015219	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
318586015220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015221	putative PBP binding loops; other site
318586015222	dimer interface [polypeptide binding]; other site
318586015223	ABC-ATPase subunit interface; other site
318586015224	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
318586015225	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586015226	Walker A/P-loop; other site
318586015227	ATP binding site [chemical binding]; other site
318586015228	Q-loop/lid; other site
318586015229	ABC transporter signature motif; other site
318586015230	Walker B; other site
318586015231	D-loop; other site
318586015232	H-loop/switch region; other site
318586015233	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
318586015234	Walker A/P-loop; other site
318586015235	ATP binding site [chemical binding]; other site
318586015236	Q-loop/lid; other site
318586015237	ABC transporter signature motif; other site
318586015238	Walker B; other site
318586015239	D-loop; other site
318586015240	H-loop/switch region; other site
318586015241	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
318586015242	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
318586015243	Transcriptional regulators [Transcription]; Region: PurR; COG1609
318586015244	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
318586015245	DNA binding site [nucleotide binding]
318586015246	domain linker motif; other site
318586015247	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
318586015248	putative dimerization interface [polypeptide binding]; other site
318586015249	putative ligand binding site [chemical binding]; other site
318586015250	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
318586015251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015252	dimer interface [polypeptide binding]; other site
318586015253	conserved gate region; other site
318586015254	putative PBP binding loops; other site
318586015255	ABC-ATPase subunit interface; other site
318586015256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015257	dimer interface [polypeptide binding]; other site
318586015258	conserved gate region; other site
318586015259	putative PBP binding loops; other site
318586015260	ABC-ATPase subunit interface; other site
318586015261	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
318586015262	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
318586015263	substrate binding pocket [chemical binding]; other site
318586015264	membrane-bound complex binding site; other site
318586015265	hinge residues; other site
318586015266	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
318586015267	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
318586015268	Walker A/P-loop; other site
318586015269	ATP binding site [chemical binding]; other site
318586015270	Q-loop/lid; other site
318586015271	ABC transporter signature motif; other site
318586015272	Walker B; other site
318586015273	D-loop; other site
318586015274	H-loop/switch region; other site
318586015275	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
318586015276	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
318586015277	NAD binding site [chemical binding]; other site
318586015278	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
318586015279	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
318586015280	substrate binding site [chemical binding]; other site
318586015281	ATP binding site [chemical binding]; other site
318586015282	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
318586015283	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
318586015284	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
318586015285	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586015286	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
318586015287	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
318586015288	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
318586015289	active site
318586015290	FMN binding site [chemical binding]; other site
318586015291	substrate binding site [chemical binding]; other site
318586015292	homotetramer interface [polypeptide binding]; other site
318586015293	catalytic residue [active]
318586015294	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
318586015295	classical (c) SDRs; Region: SDR_c; cd05233
318586015296	NAD(P) binding site [chemical binding]; other site
318586015297	active site
318586015298	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
318586015299	MarR family; Region: MarR; pfam01047
318586015300	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
318586015301	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
318586015302	substrate binding site [chemical binding]; other site
318586015303	oxyanion hole (OAH) forming residues; other site
318586015304	trimer interface [polypeptide binding]; other site
318586015305	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
318586015306	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
318586015307	active site
318586015308	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
318586015309	active site
318586015310	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
318586015311	homotrimer interaction site [polypeptide binding]; other site
318586015312	putative active site [active]
318586015313	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
318586015314	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
318586015315	acyl-activating enzyme (AAE) consensus motif; other site
318586015316	AMP binding site [chemical binding]; other site
318586015317	active site
318586015318	CoA binding site [chemical binding]; other site
318586015319	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
318586015320	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
318586015321	putative ligand binding site [chemical binding]; other site
318586015322	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
318586015323	TM-ABC transporter signature motif; other site
318586015324	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
318586015325	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
318586015326	TM-ABC transporter signature motif; other site
318586015327	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
318586015328	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
318586015329	Walker A/P-loop; other site
318586015330	ATP binding site [chemical binding]; other site
318586015331	Q-loop/lid; other site
318586015332	ABC transporter signature motif; other site
318586015333	Walker B; other site
318586015334	D-loop; other site
318586015335	H-loop/switch region; other site
318586015336	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
318586015337	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
318586015338	Walker A/P-loop; other site
318586015339	ATP binding site [chemical binding]; other site
318586015340	Q-loop/lid; other site
318586015341	ABC transporter signature motif; other site
318586015342	Walker B; other site
318586015343	D-loop; other site
318586015344	H-loop/switch region; other site
318586015345	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
318586015346	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
318586015347	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
318586015348	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
318586015349	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
318586015350	Soluble P-type ATPase [General function prediction only]; Region: COG4087
318586015351	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
318586015352	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
318586015353	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
318586015354	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
318586015355	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
318586015356	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
318586015357	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
318586015358	Subunit I/III interface [polypeptide binding]; other site
318586015359	Subunit III/IV interface [polypeptide binding]; other site
318586015360	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
318586015361	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
318586015362	D-pathway; other site
318586015363	Putative ubiquinol binding site [chemical binding]; other site
318586015364	Low-spin heme (heme b) binding site [chemical binding]; other site
318586015365	Putative water exit pathway; other site
318586015366	Binuclear center (heme o3/CuB) [ion binding]; other site
318586015367	K-pathway; other site
318586015368	Putative proton exit pathway; other site
318586015369	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
318586015370	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
318586015371	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
318586015372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
318586015373	putative substrate translocation pore; other site
318586015374	FOG: CBS domain [General function prediction only]; Region: COG0517
318586015375	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
318586015376	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
318586015377	metal binding triad; other site
318586015378	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
318586015379	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
318586015380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
318586015381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
318586015382	dimer interface [polypeptide binding]; other site
318586015383	phosphorylation site [posttranslational modification]
318586015384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
318586015385	ATP binding site [chemical binding]; other site
318586015386	Mg2+ binding site [ion binding]; other site
318586015387	G-X-G motif; other site
318586015388	Response regulator receiver domain; Region: Response_reg; pfam00072
318586015389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
318586015390	active site
318586015391	phosphorylation site [posttranslational modification]
318586015392	intermolecular recognition site; other site
318586015393	dimerization interface [polypeptide binding]; other site
318586015394	PAS domain; Region: PAS_9; pfam13426
318586015395	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
318586015396	active site
318586015397	catalytic site [active]
318586015398	substrate binding site [chemical binding]; other site
318586015399	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
318586015400	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
318586015401	agmatinase; Region: agmatinase; TIGR01230
318586015402	oligomer interface [polypeptide binding]; other site
318586015403	putative active site [active]
318586015404	Mn binding site [ion binding]; other site
318586015405	Serine hydrolase; Region: Ser_hydrolase; pfam06821
318586015406	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
318586015407	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
318586015408	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
318586015409	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
318586015410	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
318586015411	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
318586015412	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
318586015413	putative DNA binding site [nucleotide binding]; other site
318586015414	putative Zn2+ binding site [ion binding]; other site
318586015415	AsnC family; Region: AsnC_trans_reg; pfam01037
318586015416	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
318586015417	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
318586015418	active site
318586015419	non-prolyl cis peptide bond; other site
318586015420	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
318586015421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
318586015422	dimer interface [polypeptide binding]; other site
318586015423	conserved gate region; other site
318586015424	putative PBP binding loops; other site
318586015425	ABC-ATPase subunit interface; other site
318586015426	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
318586015427	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
318586015428	membrane-bound complex binding site; other site
318586015429	hinge residues; other site
318586015430	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
318586015431	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
318586015432	Walker A/P-loop; other site
318586015433	ATP binding site [chemical binding]; other site
318586015434	Q-loop/lid; other site
318586015435	ABC transporter signature motif; other site
318586015436	Walker B; other site
318586015437	D-loop; other site
318586015438	H-loop/switch region; other site
318586015439	RNA polymerase sigma factor; Provisional; Region: PRK12528
318586015440	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
318586015441	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
318586015442	DNA binding residues [nucleotide binding]
318586015443	fec operon regulator FecR; Reviewed; Region: PRK09774
318586015444	FecR protein; Region: FecR; pfam04773
318586015445	Secretin and TonB N terminus short domain; Region: STN; smart00965
318586015446	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
318586015447	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
318586015448	N-terminal plug; other site
318586015449	ligand-binding site [chemical binding]; other site
318586015450	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
318586015451	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
318586015452	HlyD family secretion protein; Region: HlyD_3; pfam13437
318586015453	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
318586015454	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
318586015455	Walker A/P-loop; other site
318586015456	ATP binding site [chemical binding]; other site
318586015457	Q-loop/lid; other site
318586015458	ABC transporter signature motif; other site
318586015459	Walker B; other site
318586015460	D-loop; other site
318586015461	H-loop/switch region; other site
318586015462	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
318586015463	FtsX-like permease family; Region: FtsX; pfam02687
318586015464	Uncharacterized conserved protein [Function unknown]; Region: COG3391